Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target?

Yoshihiro Ohue ¹, Hiroyoshi Nishikawa ¹

Affiliations

¹ Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo, Japan.

PMID: 31102428
83 References
176 citations

Abstract

Regulatory T (Treg) cells suppress abnormal/excessive immune responses to self- and nonself-antigens to maintain immune homeostasis. In tumor immunity, Treg cells are involved in tumor development and progression by inhibiting antitumor immunity. There are several Treg cell immune suppressive mechanisms: inhibition of costimulatory signals by CD80 and CD86 expressed by dendritic cells through cytotoxic T-lymphocyte antigen-4, interleukin (IL)-2 consumption by high-affinity IL-2 receptors with high CD25 (IL-2 receptor α-chain) expression, secretion of inhibitory cytokines, metabolic modulation of tryptophan and adenosine, and direct killing of effector T cells. Infiltration of Treg cells into the tumor microenvironment (TME) occurs in multiple murine and human tumors. Regulatory T cells are chemoattracted to the TME by chemokine gradients such as CCR4-CCL17/22, CCR8-CCL1, CCR10-CCL28, and CXCR3-CCL9/10/11. Regulatory T cells are then activated and inhibit antitumor immune responses. A high infiltration by Treg cells is associated with poor survival in various types of cancer. Therefore, strategies to deplete Treg cells and control of Treg cell functions to increase antitumor immune responses are urgently required in the cancer immunotherapy field. Various molecules that are highly expressed by Treg cells, such as immune checkpoint molecules, chemokine receptors, and metabolites, have been targeted by Abs or small molecules, but additional strategies are needed to fine-tune and optimize for augmenting antitumor effects restricted in the TME while avoiding systemic autoimmunity. Here, we provide a brief synopsis of these cells in cancer and how they can be controlled to achieve therapeutic outcomes.

Keywords: Treg; immune checkpoint; immune suppression; tolerance; tumor.

Other Links

Free PMC article
Full text on Cancer science

References
Cited By

References
Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Robert D Schreiber, Lloyd J Old, Mark J Smyth. Science, 2011 Mar 26; 331(6024). PMID: 21436444 Highly Cited. Review.
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. C L Bennett, J Christie, +7 authors, H D Ochs. less Nat Genet, 2001 Jan 04; 27(1). PMID: 11137993 Highly Cited.
CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells. Sayuri Yamazaki, Diana Dudziak, +5 authors, Ralph M Steinman. less J Immunol, 2008 Nov 05; 181(10). PMID: 18981112 Free PMC article. Highly Cited.
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Qizhi Tang, Jason Y Adams, +7 authors, Jeffrey A Bluestone. less Nat Immunol, 2005 Nov 29; 7(1). PMID: 16311599 Free PMC article. Highly Cited.
Increase in activated Treg in TIL in lung cancer and in vitro depletion of Treg by ADCC using an antihuman CCR4 mAb (KM2760). Koji Kurose, Yoshihiro Ohue, +7 authors, Eiichi Nakayama. less J Thorac Oncol, 2014 Oct 18; 10(1). PMID: 25325779
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Jun Shimizu, Sayuri Yamazaki, +2 authors, Takeshi Takahashi, Yasumasa Ishida, Shimon Sakaguchi. less Nat Immunol, 2002 Jan 29; 3(2). PMID: 11812990 Highly Cited.
Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. T Takahashi, Y Kuniyasu, +5 authors, S Sakaguchi. less Int Immunol, 1999 Jan 14; 10(12). PMID: 9885918 Highly Cited.
Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells. T E Carey, T Takahashi, +2 authors, L A Resnick, H F Oettgen, L J Old. less Proc Natl Acad Sci U S A, 1976 Sep 01; 73(9). PMID: 1067619 Free PMC article. Highly Cited.
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses. Lucy S K Walker, David M Sansom. Nat Rev Immunol, 2011 Nov 26; 11(12). PMID: 22116087 Highly Cited.
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Stephan Sauer, Ludovica Bruno, +10 authors, Matthias Merkenschlager. less Proc Natl Acad Sci U S A, 2008 May 30; 105(22). PMID: 18509048 Free PMC article. Highly Cited.
Structure and developmental expression of mouse Garp, a gene encoding a new leucine-rich repeat-containing protein. R Roubin, S Pizette, +3 authors, V Ollendorff, J Planche, D Birnbaum, O Delapeyriere. less Int J Dev Biol, 1996 Jun 01; 40(3). PMID: 8840187
T Cell Dysfunction in Cancer. Daniela S Thommen, Ton N Schumacher. Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634943 Free PMC article. Highly Cited. Review.
VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancer. Magali Terme, Simon Pernot, +7 authors, Julien Taieb. less Cancer Res, 2012 Oct 31; 73(2). PMID: 23108136 Highly Cited.
Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Shimizu, S Yamazaki, S Sakaguchi. J Immunol, 1999 Nov 24; 163(10). PMID: 10553041 Highly Cited.
Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Y Nishizuka, T Sakakura. Science, 1969 Nov 07; 166(3906). PMID: 5823314 Highly Cited.
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Xuefang Cao, Sheng F Cai, +4 authors, Timothy J Ley. less Immunity, 2007 Oct 09; 27(4). PMID: 17919943 Highly Cited.
CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients. Andrew J Rech, Rosemarie Mick, +13 authors, Robert H Vonderheide. less Sci Transl Med, 2012 May 18; 4(134). PMID: 22593175 Free PMC article. Highly Cited.
Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Mark J Selby, John J Engelhardt, +4 authors, Alan J Korman. less Cancer Immunol Res, 2014 Apr 30; 1(1). PMID: 24777248 Highly Cited.
CCR8+FOXp3+ Treg cells as master drivers of immune regulation. Yiftah Barsheshet, Gizi Wildbaum, +5 authors, Nathan Karin. less Proc Natl Acad Sci U S A, 2017 May 24; 114(23). PMID: 28533380 Free PMC article.
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Yoshiko Iwai, Masayoshi Ishida, +3 authors, Nagahiro Minato. less Proc Natl Acad Sci U S A, 2002 Sep 10; 99(19). PMID: 12218188 Free PMC article. Highly Cited.
Regulatory T cell-resistant CD8+ T cells induced by glucocorticoid-induced tumor necrosis factor receptor signaling. Hiroyoshi Nishikawa, Takuma Kato, +6 authors, Hiroshi Shiku. less Cancer Res, 2008 Jul 18; 68(14). PMID: 18632650
Identification of HSP90 inhibitors as a novel class of senolytics. Heike Fuhrmann-Stroissnigg, Yuan Yuan Ling, +17 authors, Paul D Robbins. less Nat Commun, 2017 Sep 06; 8(1). PMID: 28871086 Free PMC article. Highly Cited.
Targeting TGF-β Signaling in Cancer. Selcuk Colak, Peter Ten Dijke. Trends Cancer, 2017 Jul 19; 3(1). PMID: 28718426 Highly Cited. Review.
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Alexandria Huynh, Michel DuPage, +9 authors, Laurence A Turka. less Nat Immunol, 2015 Jan 07; 16(2). PMID: 25559257 Free PMC article. Highly Cited.
Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans. Makoto Miyara, Driss Chader, +14 authors, Guy Gorochov. less Proc Natl Acad Sci U S A, 2015 May 28; 112(23). PMID: 26015572 Free PMC article. Highly Cited.
Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target? Yoshihiro Ohue, Hiroyoshi Nishikawa. Cancer Sci, 2019 May 19; 110(7). PMID: 31102428 Free PMC article. Highly Cited. Review.
Tumour-associated macrophages as treatment targets in oncology. Alberto Mantovani, Federica Marchesi, +2 authors, Alberto Malesci, Luigi Laghi, Paola Allavena. less Nat Rev Clin Oncol, 2017 Jan 25; 14(7). PMID: 28117416 Free PMC article. Highly Cited. Review.
Role of LAG-3 in regulatory T cells. Ching-Tai Huang, Creg J Workman, +11 authors, Dario A A Vignali. less Immunity, 2004 Oct 16; 21(4). PMID: 15485628 Highly Cited.
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. Y Ishida, Y Agata, K Shibahara, T Honjo. EMBO J, 1992 Nov 01; 11(11). PMID: 1396582 Free PMC article. Highly Cited.
Effects of immunosuppressants on induction of regulatory cells after intratracheal delivery of alloantigen. Shintaro Shibutani, Fumihiko Inoue, +7 authors, Masanori Niimi. less Transplantation, 2005 Apr 26; 79(8). PMID: 15849542
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. Alessia Angelin, Luis Gil-de-Gómez, +17 authors, Ulf H Beier. less Cell Metab, 2017 Apr 19; 25(6). PMID: 28416194 Free PMC article. Highly Cited.
Detection of self-reactive CD8⁺ T cells with an anergic phenotype in healthy individuals. Yuka Maeda, Hiroyoshi Nishikawa, +8 authors, Shimon Sakaguchi. less Science, 2014 Dec 20; 346(6216). PMID: 25525252
Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. Yannick Bulliard, Rose Jolicoeur, +6 authors, Jennifer L Brogdon. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897982 Free PMC article. Highly Cited.
ICOS co-stimulatory receptor is essential for T-cell activation and function. C Dong, A E Juedes, +4 authors, R A Flavell. less Nature, 2001 May 09; 409(6816). PMID: 11343121 Highly Cited.
Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells. Daniel T Patton, Oliver A Garden, +8 authors, Klaus Okkenhaug. less J Immunol, 2006 Nov 04; 177(10). PMID: 17082571 Highly Cited.
LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites. Chiara Camisaschi, Chiara Casati, +7 authors, Chiara Castelli. less J Immunol, 2010 Apr 28; 184(11). PMID: 20421648
Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor. Tomasz Maj, Wei Wang, +11 authors, Weiping Zou. less Nat Immunol, 2017 Oct 31; 18(12). PMID: 29083399 Free PMC article. Highly Cited.
Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer. George Plitas, Catherine Konopacki, +5 authors, Alexander Y Rudensky. less Immunity, 2016 Nov 17; 45(5). PMID: 27851913 Free PMC article. Highly Cited.
Rational design of anti-GITR-based combination immunotherapy. Roberta Zappasodi, Cynthia Sirard, +16 authors, Taha Merghoub. less Nat Med, 2019 May 01; 25(5). PMID: 31036879 Free PMC article. Highly Cited.
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Koji Atarashi, Takeshi Tanoue, +19 authors, Kenya Honda. less Nature, 2013 Jul 12; 500(7461). PMID: 23842501 Highly Cited.
Generation and decay of the immune response to a progressive fibrosarcoma. I. Ly-1+2- suppressor T cells down-regulate the generation of Ly-1-2+ effector T cells. R J North, I Bursuker. J Exp Med, 1984 May 01; 159(5). PMID: 6232335 Free PMC article. Highly Cited.
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. Ruka Setoguchi, Shohei Hori, Takeshi Takahashi, Shimon Sakaguchi. J Exp Med, 2005 Mar 09; 201(5). PMID: 15753206 Free PMC article. Highly Cited.
Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients. Koji Kurose, Yoshihiro Ohue, +13 authors, Eiichi Nakayama. less Clin Cancer Res, 2015 Oct 03; 21(19). PMID: 26429981 Highly Cited.
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. M E Brunkow, E W Jeffery, +7 authors, F Ramsdell. less Nat Genet, 2001 Jan 04; 27(1). PMID: 11138001 Highly Cited.
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Andrea Facciabene, Xiaohui Peng, +8 authors, George Coukos. less Nature, 2011 Jul 15; 475(7355). PMID: 21753853 Highly Cited.
Regulatory T cells: key controllers of immunologic self-tolerance. S Sakaguchi. Cell, 2000 Jun 13; 101(5). PMID: 10850488 Highly Cited. Review.
Natural and induced T regulatory cells in cancer. Dennis O Adeegbe, Hiroyoshi Nishikawa. Front Immunol, 2013 Jul 23; 4. PMID: 23874336 Free PMC article. Highly Cited.
Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10. Bertus Eksteen, Alice Miles, +4 authors, David H Adams. less J Immunol, 2006 Jun 21; 177(1). PMID: 16785557
Myeloid-Derived Suppressor Cells. Dmitry I Gabrilovich. Cancer Immunol Res, 2017 Jan 06; 5(1). PMID: 28052991 Free PMC article. Highly Cited. Review.
Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Khaled Ali, Dalya R Soond, +11 authors, Bart Vanhaesebroeck. less Nature, 2014 Jun 12; 510(7505). PMID: 24919154 Free PMC article. Highly Cited.
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model. Baihao Zhang, Shunsuke Chikuma, +2 authors, Shohei Hori, Sidonia Fagarasan, Tasuku Honjo. less Proc Natl Acad Sci U S A, 2016 Jul 14; 113(30). PMID: 27410049 Free PMC article. Highly Cited.
CXCR3 signaling reduces the severity of experimental autoimmune encephalomyelitis by controlling the parenchymal distribution of effector and regulatory T cells in the central nervous system. Marcus Müller, Sally L Carter, +8 authors, Iain L Campbell. less J Immunol, 2007 Aug 22; 179(5). PMID: 17709491
Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. S Onizuka, I Tawara, +3 authors, J Shimizu, S Sakaguchi, T Fujita, E Nakayama. less Cancer Res, 1999 Jul 09; 59(13). PMID: 10397255 Highly Cited.
Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Chong T Luo, Will Liao, +2 authors, Saida Dadi, Ahmed Toure, Ming O Li. less Nature, 2016 Jan 21; 529(7587). PMID: 26789248 Free PMC article. Highly Cited.
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Y Chen, V K Kuchroo, +2 authors, J Inobe, D A Hafler, H L Weiner. less Science, 1994 Aug 26; 265(5176). PMID: 7520605 Highly Cited.
CD4+ CD25+ T cells responding to serologically defined autoantigens suppress antitumor immune responses. Hiroyoshi Nishikawa, Takuma Kato, +11 authors, Hiroshi Shiku. less Proc Natl Acad Sci U S A, 2003 Aug 30; 100(19). PMID: 12947044 Free PMC article.
The immune contexture in human tumours: impact on clinical outcome. Wolf Herman Fridman, Franck Pagès, Catherine Sautès-Fridman, Jérôme Galon. Nat Rev Cancer, 2012 Mar 16; 12(4). PMID: 22419253 Highly Cited. Review.
Inhibitory Receptors and Pathways of Lymphocytes: The Role of PD-1 in Treg Development and Their Involvement in Autoimmunity Onset and Cancer Progression. Elena Gianchecchi, Alessandra Fierabracci. Front Immunol, 2018 Nov 06; 9. PMID: 30386337 Free PMC article. Highly Cited. Review.
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Daniel Mucida, Yunji Park, +4 authors, Hilde Cheroutre. less Science, 2007 Jun 16; 317(5835). PMID: 17569825 Highly Cited.
Orchestrating the orchestrators: chemokines in control of T cell traffic. Shannon K Bromley, Thorsten R Mempel, Andrew D Luster. Nat Immunol, 2008 Aug 20; 9(9). PMID: 18711434 Highly Cited. Review.
Discontinuation of dasatinib in patients with chronic myeloid leukaemia who have maintained deep molecular response for longer than 1 year (DADI trial): a multicentre phase 2 trial. Jun Imagawa, Hideo Tanaka, +24 authors, DADI Trial Group. less Lancet Haematol, 2015 Dec 22; 2(12). PMID: 26686407 Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981 Free PMC article. Highly Cited.
Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers. Takuro Saito, Hiroyoshi Nishikawa, +19 authors, Shimon Sakaguchi. less Nat Med, 2016 Apr 26; 22(6). PMID: 27111280 Highly Cited.
Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. Rui Wang, Qi Wan, +2 authors, Lina Kozhaya, Hodaka Fujii, Derya Unutmaz. less PLoS One, 2008 Jul 17; 3(7). PMID: 18628982 Free PMC article.
IDO expression by dendritic cells: tolerance and tryptophan catabolism. Andrew L Mellor, David H Munn. Nat Rev Immunol, 2004 Oct 02; 4(10). PMID: 15459668 Highly Cited. Review.
CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative. François Ghiringhelli, Nicolas Larmonier, +7 authors, François Martin. less Eur J Immunol, 2004 Feb 10; 34(2). PMID: 14768038 Highly Cited.
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. WanJun Chen, Wenwen Jin, +5 authors, Sharon M Wahl. less J Exp Med, 2003 Dec 17; 198(12). PMID: 14676299 Free PMC article. Highly Cited.
Signaling through OX40 enhances antitumor immunity. Shawn M Jensen, Levi D Maston, +16 authors, Bernard A Fox. less Semin Oncol, 2010 Nov 16; 37(5). PMID: 21074068 Free PMC article. Review.
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer. Takahiro Kamada, Yosuke Togashi, +13 authors, Hiroyoshi Nishikawa. less Proc Natl Acad Sci U S A, 2019 Apr 28; 116(20). PMID: 31028147 Free PMC article. Highly Cited.
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. Weihong Liu, Amy L Putnam, +11 authors, Jeffrey A Bluestone. less J Exp Med, 2006 Jul 05; 203(7). PMID: 16818678 Free PMC article. Highly Cited.
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans. Daisuke Sugiyama, Hiroyoshi Nishikawa, +10 authors, Shimon Sakaguchi. less Proc Natl Acad Sci U S A, 2013 Oct 16; 110(44). PMID: 24127572 Free PMC article. Highly Cited.
Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction. Christian A Bauer, Edward Y Kim, +3 authors, Thorsten R Mempel. less J Clin Invest, 2014 May 09; 124(6). PMID: 24812664 Free PMC article. Highly Cited.
ICOS+ Foxp3+ TILs in gastric cancer are prognostic markers and effector regulatory T cells associated with Helicobacter pylori. Hirotsugu Nagase, Tomohira Takeoka, +10 authors, Hisashi Wada. less Int J Cancer, 2016 Oct 28; 140(3). PMID: 27756099
The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Lauren W Collison, Creg J Workman, +7 authors, Dario A A Vignali. less Nature, 2007 Nov 23; 450(7169). PMID: 18033300 Highly Cited.
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Omar S Qureshi, Yong Zheng, +12 authors, David M Sansom. less Science, 2011 Apr 09; 332(6029). PMID: 21474713 Free PMC article. Highly Cited.
Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8+ T cells in the tumor microenvironment. Yasuko Tada, Yosuke Togashi, +7 authors, Kohei Shitara. less J Immunother Cancer, 2018 Oct 14; 6(1). PMID: 30314524 Free PMC article.
Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis. Jun Wei, Lingyun Long, +8 authors, Hongbo Chi. less Nat Immunol, 2016 Jan 26; 17(3). PMID: 26808230 Free PMC article. Highly Cited.
Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Sharad Shrestha, Kai Yang, +3 authors, Hongbo Chi. less Nat Immunol, 2015 Jan 07; 16(2). PMID: 25559258 Free PMC article. Highly Cited.
Tumor-infiltrating human CD4+ regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity. Mojgan Ahmadzadeh, Anna Pasetto, +4 authors, Steven A Rosenberg. less Sci Immunol, 2019 Jan 13; 4(31). PMID: 30635355 Free PMC article. Highly Cited.
Tumor immunotherapy directed at PD-1. Antoni Ribas. N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658126 Highly Cited.
Clinical experience with denileukin diftitox (ONTAK). Francine Foss. Semin Oncol, 2006 Mar 07; 33(1 Suppl 3). PMID: 16516670 Review.
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Catherine Uyttenhove, Luc Pilotte, +5 authors, Benoît J Van den Eynde. less Nat Med, 2003 Sep 23; 9(10). PMID: 14502282 Highly Cited.
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Makoto Miyara, Yumiko Yoshioka, +15 authors, Shimon Sakaguchi. less Immunity, 2009 May 26; 30(6). PMID: 19464196 Highly Cited.

Citedby
T-Regulatory Cells In Tumor Progression And Therapy. Amit Verma, Rohit Mathur, +3 authors, Bilikere S Dwarakanath. less Cancer Manag Res, 2020 Jan 11; 11. PMID: 31920383 Free PMC article. Review.
[Metformin inhibits proliferation and functions of regulatory T cells in acidic environment]. Lili Wei, Zhouxiang Luo, +7 authors, Zhiming Hu. less Nan Fang Yi Ke Da Xue Xue Bao, 2020 Jan 08; 39(12). PMID: 31907158 Free PMC article.
Repurposing the serotonin agonist Tegaserod as an anticancer agent in melanoma: molecular mechanisms and clinical implications. Wei Liu, Paweł Stachura, +9 authors, Aleksandra A Pandyra. less J Exp Clin Cancer Res, 2020 Feb 23; 39(1). PMID: 32085796 Free PMC article.
Interleukin 23 and autoimmune diseases: current and possible future therapies. Ahmad Ismail Khaled Abdo, Gee Jun Tye. Inflamm Res, 2020 Mar 28; 69(5). PMID: 32215665 Review.
Tumor Targeted Nanocarriers for Immunotherapy. Alejandro Baeza. Molecules, 2020 Apr 01; 25(7). PMID: 32225049 Free PMC article. Review.
Harnessing helminth-driven immunoregulation in the search for novel therapeutic modalities. Stephanie M Ryan, Ramon M Eichenberger, +2 authors, Roland Ruscher, Paul R Giacomin, Alex Loukas. less PLoS Pathog, 2020 May 15; 16(5). PMID: 32407385 Free PMC article. Review.
Intestinal microbiota: a new force in cancer immunotherapy. Zhujiang Dai, Jingqiu Zhang, +6 authors, Daorong Wang. less Cell Commun Signal, 2020 Jun 12; 18(1). PMID: 32522267 Free PMC article. Review.
"High Treg" Inflammations Promote (Most) Non-Hematologic Cancers While "Low Treg" Inflammations Promote Lymphoid Cancers. Zeev Elkoshi. J Inflamm Res, 2020 Jun 18; 13. PMID: 32547153 Free PMC article.
Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target. Nguyen Minh Tuan, Chang Hoon Lee. Cancers (Basel), 2020 Jun 21; 12(6). PMID: 32560530 Free PMC article. Review.
Fluoropyrimidine Modulation of the Anti-Tumor Immune Response-Prospects for Improved Colorectal Cancer Treatment. William H Gmeiner. Cancers (Basel), 2020 Jun 25; 12(6). PMID: 32575843 Free PMC article. Review.
The Role of IgG4 in the Fine Tuning of Tolerance in IgE-Mediated Allergy and Cancer. Rodolfo Bianchini, Sophia N Karagiannis, Galateja Jordakieva, Erika Jensen-Jarolim. Int J Mol Sci, 2020 Jul 28; 21(14). PMID: 32708690 Free PMC article. Review.
Therapeutic Strategies for Overcoming Immunotherapy Resistance Mediated by Immunosuppressive Factors of the Glioblastoma Microenvironment. Tsubasa Miyazaki, Eiichi Ishikawa, Narushi Sugii, Masahide Matsuda. Cancers (Basel), 2020 Jul 28; 12(7). PMID: 32707672 Free PMC article. Review.
PD-L1 Is Expressed and Promotes the Expansion of Regulatory T Cells in Acute Myeloid Leukemia. Yuqing Dong, Yixiang Han, +6 authors, Shenghui Zhang. less Front Immunol, 2020 Aug 28; 11. PMID: 32849603 Free PMC article.
Hypoxia Alters the Expression of CC Chemokines and CC Chemokine Receptors in a Tumor-A Literature Review. Jan Korbecki, Klaudyna Kojder, +4 authors, Irena Baranowska-Bosiacka. less Int J Mol Sci, 2020 Aug 13; 21(16). PMID: 32781743 Free PMC article. Review.
Significance of Immunosuppressive Cells as a Target for Immunotherapies in Melanoma and Non-Melanoma Skin Cancers. Taku Fujimura, Setsuya Aiba. Biomolecules, 2020 Jul 28; 10(8). PMID: 32707850 Free PMC article. Review.
To Remember or to Forget: The Role of Good and Bad Memories in Adoptive T Cell Therapy for Tumors. Anna Mondino, Teresa Manzo. Front Immunol, 2020 Sep 26; 11. PMID: 32973794 Free PMC article. Review.
Characteristics of Malignant Pleural Effusion Resident CD8+ T Cells from a Heterogeneous Collection of Tumors. Rajeev Dhupar, Olugbenga T Okusanya, +8 authors, Adam C Soloff. less Int J Mol Sci, 2020 Sep 02; 21(17). PMID: 32867034 Free PMC article.
Extracellular Vesicles in the Tumour Microenvironment: Eclectic Supervisors. Claudia Cavallari, Giovanni Camussi, Maria Felice Brizzi. Int J Mol Sci, 2020 Sep 19; 21(18). PMID: 32942702 Free PMC article. Review.
Galunisertib Drives Treg Fragility and Promotes Dendritic Cell-Mediated Immunity against Experimental Lymphoma. Sumit Kumar Hira, Abhinandan Rej, +5 authors, Partha Pratim Manna. less iScience, 2020 Oct 23; 23(10). PMID: 33089111 Free PMC article.
Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone. Gang Cheng, Micael Hardy, +4 authors, Balaraman Kalyanaraman. less Sci Rep, 2020 Oct 23; 10(1). PMID: 33087770 Free PMC article.
Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment. Debolina Ganguly, Raghav Chandra, +10 authors, Matteo Ligorio. less Cancers (Basel), 2020 Sep 23; 12(9). PMID: 32957515 Free PMC article. Review.
EZH2 inhibition: a promising strategy to prevent cancer immune editing. Ning Kang, Mark Eccleston, +4 authors, Francesco Crea. less Epigenomics, 2020 Sep 18; 12(16). PMID: 32938196 Free PMC article. Review.
The effect of CCL5 on the immune cells infiltration and the prognosis of patients with kidney renal clear cell carcinoma. Shuheng Bai, YinYing Wu, +8 authors, Juan Ren. less Int J Med Sci, 2020 Nov 12; 17(18). PMID: 33173412 Free PMC article.
Lactic Acid and an Acidic Tumor Microenvironment suppress Anticancer Immunity. Joy X Wang, Stephen Y C Choi, +4 authors, Yuzhuo Wang. less Int J Mol Sci, 2020 Nov 12; 21(21). PMID: 33171818 Free PMC article. Review.
TMEM205 Is an Independent Prognostic Factor and Is Associated With Immune Cell Infiltrates in Hepatocellular Carcinoma. Jiawei Rao, Xukun Wu, +2 authors, Xiaozhuan Zhou, Ronghai Deng, Yi Ma. less Front Genet, 2020 Nov 17; 11. PMID: 33193690 Free PMC article.
Tet2 at the interface between cancer and immunity. Shuai Jiang. Commun Biol, 2020 Nov 14; 3(1). PMID: 33184433 Free PMC article. Review.
Microbial Biosurfactants in Cosmetic and Personal Skincare Pharmaceutical Formulations. Simms A Adu, Patrick J Naughton, Roger Marchant, Ibrahim M Banat. Pharmaceutics, 2020 Nov 20; 12(11). PMID: 33207832 Free PMC article. Review.
The Janus Face of Tumor Microenvironment Targeted by Immunotherapy. Maria Buoncervello, Lucia Gabriele, Elena Toschi. Int J Mol Sci, 2019 Sep 06; 20(17). PMID: 31484464 Free PMC article. Review.
Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia. Furun An, Huiping Wang, +14 authors, Zhimin Zhai. less Nat Commun, 2020 Nov 25; 11(1). PMID: 33230103 Free PMC article.
Influence of oncogenic mutations and tumor microenvironment alterations on extranodal invasion in diffuse large B-cell lymphoma. Rong Shen, Peng-Peng Xu, +9 authors, Wei-Li Zhao. less Clin Transl Med, 2020 Dec 01; 10(7). PMID: 33252851 Free PMC article.
'Nur'turing tumor T cell tolerance and exhaustion: novel function for Nuclear Receptor Nur77 in immunity. Sanne C Lith, Bram W van Os, Tom T P Seijkens, Carlie J M de Vries. Eur J Immunol, 2020 Oct 17; 50(11). PMID: 33063848 Free PMC article. Review.
Regulatory T cell metabolism at the intersection between autoimmune diseases and cancer. Henry Kurniawan, Leticia Soriano-Baguet, Dirk Brenner. Eur J Immunol, 2020 Oct 18; 50(11). PMID: 33067808 Free PMC article. Review.
Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy. Ajaz A Bhat, Sabah Nisar, +17 authors, Mohammad Haris. less Mol Cancer, 2021 Jan 05; 20(1). PMID: 33390169 Free PMC article. Review.
Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors. Lorenzo Galluzzi, Juliette Humeau, +2 authors, Aitziber Buqué, Laurence Zitvogel, Guido Kroemer. less Nat Rev Clin Oncol, 2020 Aug 08; 17(12). PMID: 32760014 Review.
Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target? Yoshihiro Ohue, Hiroyoshi Nishikawa. Cancer Sci, 2019 May 19; 110(7). PMID: 31102428 Free PMC article. Highly Cited. Review.
Is There a Place for Immune Checkpoint Inhibitors in Vulvar Neoplasms? A State of the Art Review. Fulvio Borella, Mario Preti, +9 authors, Leonardo Micheletti. less Int J Mol Sci, 2020 Dec 31; 22(1). PMID: 33375467 Free PMC article. Review.
Mechanisms of Immunosuppression in Colorectal Cancer. Yang Zhang, Ashwani Rajput, Ning Jin, Jing Wang. Cancers (Basel), 2021 Jan 10; 12(12). PMID: 33419310 Free PMC article. Review.
Hematopoietic versus Solid Cancers and T Cell Dysfunction: Looking for Similarities and Distinctions. Chiara Montironi, Cristina Muñoz-Pinedo, Eric Eldering. Cancers (Basel), 2021 Jan 21; 13(2). PMID: 33466674 Free PMC article. Review.
Accumulation of TNFR2-expressing regulatory T cells in malignant pleural effusion of lung cancer patients is associated with poor prognosis. Lin-Lin Ye, Wen-Bei Peng, +7 authors, Qiong Zhou. less Ann Transl Med, 2021 Jan 26; 8(24). PMID: 33490159 Free PMC article.
Exosomes in Immune Regulation. Heidi Schwarzenbach, Peter B Gahan. Noncoding RNA, 2021 Jan 14; 7(1). PMID: 33435564 Free PMC article. Review.
Mining The Cancer Genome Atlas database for tumor mutation burden and its clinical implications in gastric cancer. Dong-Yan Zhao, Xi-Zhen Sun, Shu-Kun Yao. World J Gastrointest Oncol, 2021 Jan 30; 13(1). PMID: 33510848 Free PMC article.
The role of FOXP3 rs3761548 and rs2294021 polymorphisms in pediatrics acute lymphoblastic leukemia: association with risk and response to therapy. Zahra Ghasemi, Kurosh Kalantar, Zahra Amirghofran. Mol Biol Rep, 2021 Feb 01; 48(2). PMID: 33517519
Unfavorable impact of decreased muscle quality on the efficacy of immunotherapy for advanced non-small cell lung cancer. Naoya Nishioka, Tateaki Naito, +13 authors, Toshiaki Takahashi. less Cancer Med, 2020 Dec 11; 10(1). PMID: 33300678 Free PMC article.
The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities. Fatemeh Bayati, Mahsa Mohammadi, +3 authors, Ehsan Sharif-Paghaleh. less Front Immunol, 2021 Feb 02; 11. PMID: 33519807 Free PMC article. Review.
Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution. Yang Liu, Shuai He, +18 authors, Jin-Xin Bei. less Nat Commun, 2021 Feb 04; 12(1). PMID: 33531485 Free PMC article.
Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment. Varun Sasidharan Nair, Reem Saleh, +2 authors, Salman M Toor, Farhan S Cyprian, Eyad Elkord. less Cancer Immunol Immunother, 2021 Feb 04; 70(8). PMID: 33532902 Free PMC article. Review.
Indoleamine 2,3-Dioxygenase Activity-Induced Acceleration of Tumor Growth, and Protein Kinases-Related Novel Therapeutics Regimens. Ayse Basak Engin, Atilla Engin. Adv Exp Med Biol, 2021 Feb 05; 1275. PMID: 33539022
B7-H3×4-1BB bispecific antibody augments antitumor immunity by enhancing terminally differentiated CD8+ tumor-infiltrating lymphocytes. Gihoon You, Yangsoon Lee, +18 authors, Seung-Woo Lee. less Sci Adv, 2021 Feb 02; 7(3). PMID: 33523913 Free PMC article.
The potential role of tumor-derived exosomes in diagnosis, prognosis, and response to therapy in cancer. Malgorzata Czystowska-Kuzmicz, Theresa L Whiteside. Expert Opin Biol Ther, 2020 Aug 20; 21(2). PMID: 32813990 Free PMC article.
Smad7 suppresses melanoma lung metastasis by impairing Tregs migration to the tumor microenvironment. Deliang Ma, Li Qiao, Bingnan Guo. Am J Transl Res, 2021 Feb 18; 13(2). PMID: 33594321 Free PMC article.
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy. Tianyu Tang, Xing Huang, +3 authors, Gang Zhang, Zhengtao Hong, Xueli Bai, Tingbo Liang. less Signal Transduct Target Ther, 2021 Feb 21; 6(1). PMID: 33608497 Free PMC article. Review.
Tumor microenvironment and immune-related therapies of head and neck squamous cell carcinoma. Yixiao Qin, Xiwang Zheng, +2 authors, Wei Gao, Binquan Wang, Yongyan Wu. less Mol Ther Oncolytics, 2021 Feb 23; 20. PMID: 33614915 Free PMC article. Review.
The Distinctive Serum Metabolomes of Gastric, Esophageal and Colorectal Cancers. Zhenxing Ren, Cynthia Rajani, Wei Jia. Cancers (Basel), 2021 Feb 14; 13(4). PMID: 33578739 Free PMC article. Review.
Mycomedicine: A Unique Class of Natural Products with Potent Anti-tumour Bioactivities. Rongchen Dai, Mengfan Liu, +2 authors, Wan Najbah Nik Nabil, Zhichao Xi, Hongxi Xu. less Molecules, 2021 Mar 07; 26(4). PMID: 33669877 Free PMC article. Review.
Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing. Jenny Mattsson, Ludvig Ekdahl, +7 authors, Björn Nilsson. less Nat Commun, 2021 Feb 26; 12(1). PMID: 33627649 Free PMC article.
Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells. Ryan Kolb, Umasankar De, +16 authors, Weizhou Zhang. less Nat Commun, 2021 Feb 26; 12(1). PMID: 33627663 Free PMC article.
CCR4, CCR8, and P2RY14 as Prognostic Factors in Head and Neck Squamous Cell Carcinoma Are Involved in the Remodeling of the Tumor Microenvironment. Liangliang Meng, Xiaoxi He, +8 authors, Yueyong Xiao. less Front Oncol, 2021 Mar 12; 11. PMID: 33692955 Free PMC article.
Changes in the Peripheral Blood Treg Cell Proportion in Hepatocellular Carcinoma Patients After Transarterial Chemoembolization With Microparticles. Zhizhong Ren, Yuanxun Yue, +8 authors, Tianxiao Wang. less Front Immunol, 2021 Mar 16; 12. PMID: 33717135 Free PMC article.
Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy. Xin Peng, Youe He, +2 authors, Jun Huang, Yongguang Tao, Shuang Liu. less Front Immunol, 2021 Mar 19; 12. PMID: 33732237 Free PMC article. Review.
Critical Roles of Balanced T Helper 9 Cells and Regulatory T Cells in Allergic Airway Inflammation and Tumor Immunity. Muhua Huang, Jingcheng Dong. J Immunol Res, 2021 Mar 23; 2021. PMID: 33748292 Free PMC article. Review.
Safety and activity of the TGFβ receptor I kinase inhibitor galunisertib plus the anti-PD-L1 antibody durvalumab in metastatic pancreatic cancer. Davide Melisi, Do-Youn Oh, +16 authors, Rocio Garcia-Carbonero. less J Immunother Cancer, 2021 Mar 11; 9(3). PMID: 33688022 Free PMC article.
Prognostic Immune-Related Analysis Based on Differentially Expressed Genes in Left- and Right-Sided Colon Adenocarcinoma. Jun-Nan Guo, Ming-Qi Li, +4 authors, Yan-Long Liu. less Front Oncol, 2021 Mar 26; 11. PMID: 33763372 Free PMC article.
Co-inhibitor expression on tumor infiltrating and splenic lymphocytes after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer. Ryan J Slovak, Hong-Jai Park, +3 authors, Hyun S Kim. less Sci Rep, 2021 Mar 28; 11(1). PMID: 33772035 Free PMC article.
Type I and II Interferons in the Anti-Tumor Immune Response. Sarah E Fenton, Diana Saleiro, Leonidas C Platanias. Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33801234 Free PMC article. Review.
IL17A Depletion Affects the Metabolism of Macrophages Treated with Gemcitabine. Cecilia Roux, Gianluca Mucciolo, +3 authors, Paola Cappello. less Antioxidants (Basel), 2021 Apr 04; 10(3). PMID: 33802061 Free PMC article.
Recent Advancements on Immunomodulatory Mechanisms of Resveratrol in Tumor Microenvironment. Gagan Chhabra, Chandra K Singh, +2 authors, Deeba Amiri, Neha Akula, Nihal Ahmad. less Molecules, 2021 Apr 04; 26(5). PMID: 33802331 Free PMC article. Review.
Immune System Alterations in Multiple Myeloma: Molecular Mechanisms and Therapeutic Strategies to Reverse Immunosuppression. Andrea Díaz-Tejedor, Mauro Lorenzo-Mohamed, +4 authors, Teresa Paíno. less Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33802806 Free PMC article. Review.
The Role of CXCL16 in the Pathogenesis of Cancer and Other Diseases. Jan Korbecki, Karolina Bajdak-Rusinek, +4 authors, Irena Baranowska-Bosiacka. less Int J Mol Sci, 2021 Apr 04; 22(7). PMID: 33800554 Free PMC article. Review.
Bacteria-Based Cancer Immunotherapy. Xuehui Huang, Jingmei Pan, +4 authors, Shaobing Zhou. less Adv Sci (Weinh), 2021 Apr 16; 8(7). PMID: 33854892 Free PMC article. Review.
Identification of an Immune Gene Signature Based on Tumor Microenvironment Characteristics in Colon Adenocarcinoma. Ying Chen, Jia Zhao. Cell Transplant, 2021 Apr 01; 30. PMID: 33787354 Free PMC article.
Immuno-profiling and cellular spatial analysis using five immune oncology multiplex immunofluorescence panels for paraffin tumor tissue. Edwin Roger Parra, Maria C Ferrufino-Schmidt, +8 authors, Ignacio Ivan Wistuba. less Sci Rep, 2021 Apr 21; 11(1). PMID: 33875760 Free PMC article.
Enhanced anti-melanoma efficacy through a combination of the armed oncolytic adenovirus ZD55-IL-24 and immune checkpoint blockade in B16-bearing immunocompetent mouse model. Hai-Jun Hu, Xiu Liang, +7 authors, Xin-Yuan Liu. less Cancer Immunol Immunother, 2021 Apr 28; 70(12). PMID: 33903973 Free PMC article.
Adoptive T Cell Therapy for Solid Tumors: Pathway to Personalized Standard of Care. Shuyang S Qin, Alexa D Melucci, Alexander C Chacon, Peter A Prieto. Cells, 2021 May 01; 10(4). PMID: 33916369 Free PMC article. Review.
Combined Effects of Myeloid Cells in the Neuroblastoma Tumor Microenvironment. Jennifer Frosch, Ilia Leontari, John Anderson. Cancers (Basel), 2021 May 01; 13(7). PMID: 33917501 Free PMC article. Review.
CD80 Expression on Tumor Cells Alters Tumor Microenvironment and Efficacy of Cancer Immunotherapy by CTLA-4 Blockade. Julie Vackova, Ingrid Polakova, Shweta Dilip Johari, Michal Smahel. Cancers (Basel), 2021 May 01; 13(8). PMID: 33923750 Free PMC article.
Metabolites in the Tumor Microenvironment Reprogram Functions of Immune Effector Cells Through Epigenetic Modifications. Yijia Li, Yangzhe Wu, Yi Hu. Front Immunol, 2021 May 01; 12. PMID: 33927716 Free PMC article. Review.
Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study. Ji-Bing Chen, Xiao-Feng Kong, +4 authors, Ke-Cheng Xu. less Med Gas Res, 2021 Jan 01; 10(4). PMID: 33380580 Free PMC article.
Lenalidomide triggers T-cell effector functions in vivo in patients with follicular lymphoma. Cédric Ménard, Delphine Rossille, +10 authors, Karin Tarte. less Blood Adv, 2021 Apr 21; 5(8). PMID: 33877296 Free PMC article.
Prognostic and therapeutic role of tumor-infiltrating lymphocyte subtypes in breast cancer. Molly A Nelson, Worapol Ngamcherdtrakul, Shiuh-Wen Luoh, Wassana Yantasee. Cancer Metastasis Rev, 2021 May 09; 40(2). PMID: 33963482 Free PMC article. Review.
Reprogramming Immune Cells for Enhanced Cancer Immunotherapy: Targets and Strategies. Yan Dong, Zhuo Wan, +2 authors, Xiaotong Gao, Guodong Yang, Li Liu. less Front Immunol, 2021 May 11; 12. PMID: 33968014 Free PMC article. Review.
Natural Killer Cells and Regulatory T Cells Cross Talk in Hepatocellular Carcinoma: Exploring Therapeutic Options for the Next Decade. Amber G Bozward, Frazer Warricker, Ye H Oo, Salim I Khakoo. Front Immunol, 2021 May 18; 12. PMID: 33995362 Free PMC article. Review.
Natural Killer Cell Interactions With Myeloid Derived Suppressor Cells in the Tumor Microenvironment and Implications for Cancer Immunotherapy. Cristina Zalfa, Silke Paust. Front Immunol, 2021 May 25; 12. PMID: 34025641 Free PMC article. Review.
Mechanisms of Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers. Vito Amodio, Gianluca Mauri, +4 authors, Giovanni Germano. less Cancers (Basel), 2021 Jun 03; 13(11). PMID: 34072037 Free PMC article. Review.
A new biological triangle in cancer: intestinal microbiota, immune checkpoint inhibitors and antibiotics. Jie Zhang, Zhujiang Dai, +3 authors, Dong Tang. less Clin Transl Oncol, 2021 Jun 15; 23(12). PMID: 34125407 Free PMC article. Review.
METTL14 Acts as a Potential Regulator of Tumor Immune and Progression in Clear Cell Renal Cell Carcinoma. Tianbo Xu, Su Gao, +8 authors, Xiaoping Zhang. less Front Genet, 2021 Jun 15; 12. PMID: 34122497 Free PMC article.
Combination Strategies to Augment Immune Check Point Inhibitors Efficacy - Implications for Translational Research. Hrishi Varayathu, Vinu Sarathy, +2 authors, Radheshyam Naik. less Front Oncol, 2021 Jun 15; 11. PMID: 34123767 Free PMC article. Review.
Inflammation and tumor progression: signaling pathways and targeted intervention. Huakan Zhao, Lei Wu, +4 authors, Yongsheng Li. less Signal Transduct Target Ther, 2021 Jul 13; 6(1). PMID: 34248142 Free PMC article.
Identification of LIPH as an unfavorable biomarkers correlated with immune suppression or evasion in pancreatic cancer based on RNA-seq. Hongkai Zhuang, Xinming Chen, +4 authors, Baohua Hou. less Cancer Immunol Immunother, 2021 Jul 20; 71(3). PMID: 34279685
Identification of NOTCH4 mutation as a response biomarker for immune checkpoint inhibitor therapy. Junyu Long, Dongxu Wang, +8 authors, Haitao Zhao. less BMC Med, 2021 Jul 22; 19(1). PMID: 34284787 Free PMC article.
Long Non-Coding RNAs in the Tumor Immune Microenvironment: Biological Properties and Therapeutic Potential. Ya-Nan Pi, Wen-Cai Qi, +2 authors, Bai-Rong Xia, Ge Lou, Wei-Lin Jin. less Front Immunol, 2021 Jul 24; 12. PMID: 34295338 Free PMC article. Review.
Stimulation of Innate and Adaptive Immune Cells with Graphene Oxide and Reduced Graphene Oxide Affect Cancer Progression. Muhammad Amir Yunus, Muhammad Mahyiddin Ramli, Nurul Huda Osman, Rafeezul Mohamed. Arch Immunol Ther Exp (Warsz), 2021 Jul 31; 69(1). PMID: 34327598 Review.
Local Anti-PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model. Yewen Shi, Tong-Xin Xie, +8 authors, Roberto Rangel. less Cancer Prev Res (Phila), 2021 May 23; 14(8). PMID: 34021022 Free PMC article.
Are Changes in the Percentage of Specific Leukocyte Subpopulations Associated with Endogenous DNA Damage Levels in Testicular Cancer Patients? Katarina Kalavska, Zuzana Sestakova, +13 authors, Michal Mego. less Int J Mol Sci, 2021 Aug 08; 22(15). PMID: 34361047 Free PMC article.
Tumor growth suppression by implantation of an anti-CD25 antibody-immobilized material near the tumor via regulatory T cell capture. Tsuyoshi Kimura, Rino Tokunaga, +2 authors, Yoshihide Hashimoto, Naoko Nakamura, Akio Kishida. less Sci Technol Adv Mater, 2021 Aug 12; 22(1). PMID: 34377087 Free PMC article.
Interleukin-10: A double-edged sword in breast cancer. Chun-Ming Chang, Ho Yin Pekkle Lam, Hao-Jen Hsu, Shinn-Jong Jiang. Tzu Chi Med J, 2021 Aug 14; 33(3). PMID: 34386356 Free PMC article. Review.
Peptides that immunoactivate the tumor microenvironment. Natsuki Furukawa, Aleksander S Popel. Biochim Biophys Acta Rev Cancer, 2020 Dec 05; 1875(1). PMID: 33276025 Free PMC article. Review.
Hyperprogression under immunotherapy: a new form of immunotherapy response?-a narrative literature review. Miaozhen Lin, Ben G L Vanneste, +3 authors, Qiwen Yu, Zebin Chen, Jiayu Peng, Xiuyu Cai. less Transl Lung Cancer Res, 2021 Aug 26; 10(7). PMID: 34430364 Free PMC article. Review.
Novel Insights into the Immunotherapy of Soft Tissue Sarcomas: Do We Need a Change of Perspective? Andrej Ozaniak, Jiri Vachtenheim, +2 authors, Robert Lischke, Jirina Bartunkova, Zuzana Strizova. less Biomedicines, 2021 Aug 28; 9(8). PMID: 34440139 Free PMC article. Review.
Roles of CCL2-CCR2 Axis in the Tumor Microenvironment. Suguru Kadomoto, Kouji Izumi, Atsushi Mizokami. Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445235 Free PMC article. Review.
Failure of Immunotherapy-The Molecular and Immunological Origin of Immunotherapy Resistance in Lung Cancer. Justyna Błach, Kamila Wojas-Krawczyk, Marcin Nicoś, Paweł Krawczyk. Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445735 Free PMC article. Review.
Aptamer-mediated transcriptional gene silencing of Fox p 3 inhibits regulatory T cells and potentiates antitumor response. Andrea J Manrique-Rincón, Luciana P Ruas, +6 authors, Marcio C Bajgelman. less Mol Ther Nucleic Acids, 2021 Aug 31; 25. PMID: 34457999 Free PMC article.
The state of the art of bispecific antibodies for treating human malignancies. Shuhang Wang, Kun Chen, +16 authors, Ning Li. less EMBO Mol Med, 2021 Aug 26; 13(9). PMID: 34431224 Free PMC article. Review.
Endometriotic Peritoneal Fluid Stimulates Recruitment of CD4+CD25highFOXP3+ Treg Cells. Joanna Olkowska-Truchanowicz, Alicja Sztokfisz-Ignasiak, +6 authors, Jacek Malejczyk. less J Clin Med, 2021 Sep 11; 10(17). PMID: 34501240 Free PMC article.
Peripheral Blood-Based Biomarkers for Immune Checkpoint Inhibitors. Ho Jung An, Hong Jae Chon, Chan Kim. Int J Mol Sci, 2021 Sep 11; 22(17). PMID: 34502325 Free PMC article. Review.
Non-Small Cell Lung Cancer: Challenge and Improvement of Immune Drug Resistance. Fanming Kong, Ziwei Wang, +4 authors, Yingjie Jia. less Front Oncol, 2021 Sep 18; 11. PMID: 34532293 Free PMC article. Review.
Inhibitory Effect of Dihydroartemisinin on the Proliferation and Migration of Melanoma Cells and Experimental Lung Metastasis From Melanoma in Mice. Qi Zhang, Linbo Jin, +8 authors, Guihua Jin. less Front Pharmacol, 2021 Sep 21; 12. PMID: 34539408 Free PMC article.
The antitumor mechanisms of aerobic exercise: A review of recent preclinical studies. Ningxin Jia, Yanan Zhou, Xiaosheng Dong, Meng Ding. Cancer Med, 2021 Aug 14; 10(18). PMID: 34387383 Free PMC article. Review.
Annexin A1 as a Regulator of Immune Response in Cancer. Thaise Gonçalves Araújo, Sara Teixeira Soares Mota, +3 authors, Lara Vecchi. less Cells, 2021 Sep 29; 10(9). PMID: 34571894 Free PMC article. Review.
Glucocorticoid and PD-1 Cross-Talk: Does the Immune System Become Confused? Sabrina Adorisio, Lorenza Cannarile, Domenico V Delfino, Emira Ayroldi. Cells, 2021 Sep 29; 10(9). PMID: 34571982 Free PMC article. Review.
Lower Survival and Increased Circulating Suppressor Cells in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma with Deficit of Vitamin D Levels Using R-GDP Plus Lenalidomide (R2-GDP): Results from the R2-GDP-GOTEL Trial. Carlos Jiménez-Cortegana, Pilar M Sánchez-Martínez, +7 authors, Víctor Sánchez-Margalet. less Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572849 Free PMC article.
Downregulated TNF-α Levels after Cryo-Thermal Therapy Drive Tregs Fragility to Promote Long-Term Antitumor Immunity. Yue Lou, Junjun Wang, +3 authors, Peng Peng, Shicheng Wang, Ping Liu, Lisa X Xu. less Int J Mol Sci, 2021 Sep 29; 22(18). PMID: 34576115 Free PMC article.
Fluorescent Multiplex Immunohistochemistry Coupled With Other State-Of-The-Art Techniques to Systematically Characterize the Tumor Immune Microenvironment. Anaïs Boisson, Grégory Noël, +12 authors, Soizic Garaud. less Front Mol Biosci, 2021 Oct 09; 8. PMID: 34621785 Free PMC article.
Trans-arterial chemoembolization as a loco-regional inducer of immunogenic cell death in hepatocellular carcinoma: implications for immunotherapy. David J Pinato, Sam M Murray, +18 authors, Vincenzo Mazzaferro. less J Immunother Cancer, 2021 Oct 02; 9(9). PMID: 34593621 Free PMC article.
Low Levels of TRIM28-Interacting KRAB-ZNF Genes Associate with Cancer Stemness and Predict Poor Prognosis of Kidney Renal Clear Cell Carcinoma Patients. Patrycja Czerwinska, Andrzej Adam Mackiewicz. Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638319 Free PMC article.
Potential Therapeutic and Prognostic Values of LSM Family Genes in Breast Cancer. Hoang Dang Khoa Ta, Wei-Jan Wang, +6 authors, Kuen-Haur Lee. less Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638387 Free PMC article.
Hijacking Sexual Immuno-Privilege in GBM-An Immuno-Evasion Strategy. Martyn A Sharpe, David S Baskin, Amanda V Jenson, Alexandra M Baskin. Int J Mol Sci, 2021 Oct 24; 22(20). PMID: 34681642 Free PMC article.
Dihydroartemisinin: A Potential Drug for the Treatment of Malignancies and Inflammatory Diseases. Ran Yu, Guihua Jin, Manabu Fujimoto. Front Oncol, 2021 Oct 26; 11. PMID: 34692496 Free PMC article. Review.
A Novel S100 Family-Based Signature Associated with Prognosis and Immune Microenvironment in Glioma. Yifang Hu, Jiahang Song, +6 authors, Yun Liu. less J Oncol, 2021 Oct 30; 2021. PMID: 34712325 Free PMC article.
Screening and Prognostic Analysis of Immune-Related Genes in Pancreatic Cancer. Xin Wu, Yichao Liang. Front Genet, 2021 Nov 06; 12. PMID: 34737763 Free PMC article.
Role of FoxP3-positive regulatory T-cells in regressive and progressive cervical dysplasia. Aurelia Vattai, Nadine Kremer, +11 authors, Thomas Kolben. less J Cancer Res Clin Oncol, 2021 Nov 06; 148(2). PMID: 34739585
Distinct roles but cooperative effect of TLR3/9 agonists and PD-1 blockade in converting the immunotolerant microenvironment of irreversible electroporation-ablated tumors. Fatma Babikr, Jiangbo Wan, +10 authors, Jim Xiang. less Cell Mol Immunol, 2021 Nov 17; 18(12). PMID: 34782757 Free PMC article.
Immune Microenvironment and Response in Prostate Cancer Using Large Population Cohorts. Xiaohan Ren, Xinglin Chen, +7 authors, Chao Qin. less Front Immunol, 2021 Nov 16; 12. PMID: 34777331 Free PMC article.
Postoperative Natural Killer Cell Dysfunction: The Prime Suspect in the Case of Metastasis Following Curative Cancer Surgery. Marisa Market, Gayashan Tennakoon, Rebecca C Auer. Int J Mol Sci, 2021 Nov 14; 22(21). PMID: 34768810 Free PMC article. Review.
CCR4 as a Therapeutic Target for Cancer Immunotherapy. Osamu Yoshie. Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771703 Free PMC article. Review.
Targeting regulatory T cells for immunotherapy in melanoma. Lili Huang, Yeye Guo, +4 authors, Xiaowei Xu. less Mol Biomed, 2021 Nov 23; 2(1). PMID: 34806028 Free PMC article. Review.
Exposure to Tobacco Smoking Induces a subset of Activated Tumor-resident Tregs in Non-Small Cell Lung Cancer. Yudi Hu, Chaoqun Xu, +6 authors, Qiyuan Li. less Transl Oncol, 2021 Nov 13; 15(1). PMID: 34768099 Free PMC article.
Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function. Lídia Fortuny, Carlos Sebastián. Genes (Basel), 2021 Nov 28; 12(11). PMID: 34828304 Free PMC article. Review.
Combined Assessment of the Tumor-Stroma Ratio and Tumor Immune Cell Infiltrate for Immune Checkpoint Inhibitor Therapy Response Prediction in Colon Cancer. Cor J Ravensbergen, Meaghan Polack, +5 authors, Wilma E Mesker. less Cells, 2021 Nov 28; 10(11). PMID: 34831157 Free PMC article.
Chemokine Pathways in Cutaneous Melanoma: Their Modulation by Cancer and Exploitation by the Clinician. Rebecca Adams, Bernhard Moser, Sophia N Karagiannis, Katie E Lacy. Cancers (Basel), 2021 Nov 28; 13(22). PMID: 34830780 Free PMC article. Review.
Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy. Jianfeng Hua, Pan Wu, +5 authors, Yong Huang. less Front Oncol, 2021 Dec 07; 11. PMID: 34868932 Free PMC article. Review.
Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma. Bin Zheng, Fang Xie, +4 authors, Zhihong Niu. less Front Mol Biosci, 2021 Dec 11; 8. PMID: 34888353 Free PMC article.
Traditional Chinese Medicine Therapy for Esophageal Cancer: A Literature Review. Luchang Cao, Xinmiao Wang, +5 authors, Jie Li. less Integr Cancer Ther, 2021 Nov 27; 20. PMID: 34825600 Free PMC article. Review.
Regulatory T Cell as a Biomarker of Treatment-Free Remission in Patients with Chronic Myeloid Leukemia. Yuki Fujioka, Daisuke Sugiyama, +8 authors, Naoto Takahashi. less Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885012 Free PMC article.
Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity. Kazuhiko Matsuo, Osamu Yoshie, Takashi Nakayama. Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885241 Free PMC article. Review.
Computational Identification of Immune- and Ferroptosis-Related LncRNA Signature for Prognosis of Hepatocellular Carcinoma. Anmin Huang, Ting Li, Xueting Xie, Jinglin Xia. Front Mol Biosci, 2021 Dec 14; 8. PMID: 34901153 Free PMC article.
A radioenhancing nanoparticle mediated immunoradiation improves survival and generates long-term antitumor immune memory in an anti-PD1-resistant murine lung cancer model. Yun Hu, Sébastien Paris, +12 authors, James W Welsh. less J Nanobiotechnology, 2021 Dec 14; 19(1). PMID: 34895262 Free PMC article.
Effective Disease Control After Combinatorial Treatment with a PD-1 Antibody and an mTOR Inhibitor for Recurrent Ovarian Clear Cell Carcinomas: A Case Report and Literature Review. Yue Li, Wentao Liu, +8 authors, Dalin Li. less Onco Targets Ther, 2021 Dec 18; 14. PMID: 34916808 Free PMC article.
The Immune Regulatory Role of Protein Kinase CK2 and Its Implications for Treatment of Cancer. Huixian Hong, Etty N Benveniste. Biomedicines, 2021 Dec 25; 9(12). PMID: 34944749 Free PMC article. Review.
The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats. Jirakrit Saetang, Aman Tedasen, +5 authors, Potchanapond Graidist. less Pharm Biol, 2021 Dec 29; 60(1). PMID: 34962450 Free PMC article.
AMP-activated protein kinase alpha1 promotes tumor development via FOXP3 elevation in tumor-infiltrating Treg cells. Junqing An, Ye Ding, +5 authors, Ming-Hui Zou. less iScience, 2022 Jan 07; 25(1). PMID: 34988407 Free PMC article.
;. PMID: 35006459
Identification of the JNK-Active Triple-Negative Breast Cancer Cluster Associated With an Immunosuppressive Tumor Microenvironment. Takashi Semba, Xiaoping Wang, +7 authors, Naoto T Ueno. less J Natl Cancer Inst, 2021 Jul 13; 114(1). PMID: 34250544 Free PMC article.
Harnessing Antitumor CD4+ T Cells for Cancer Immunotherapy. Myriam Ben Khelil, Yann Godet, +3 authors, Romain Loyon. less Cancers (Basel), 2022 Jan 12; 14(1). PMID: 35008422 Free PMC article. Review.
Macrophage Polarity and Disease Control. Suguru Kadomoto, Kouji Izumi, Atsushi Mizokami. Int J Mol Sci, 2022 Jan 12; 23(1). PMID: 35008577 Free PMC article. Review.
Alteration of the immune environment in bone marrow from children with recurrent B cell precursor acute lymphoblastic leukemia. Takashi Mikami, Itaru Kato, +22 authors, Junko Takita. less Cancer Sci, 2021 Oct 31; 113(1). PMID: 34716967 Free PMC article.
miR-4759 suppresses breast cancer through immune checkpoint blockade. You-Zhe Lin, Shu-Hsuan Liu, +8 authors, Shao-Chun Wang. less Comput Struct Biotechnol J, 2022 Jan 14; 20. PMID: 35024096 Free PMC article.
Autophagy and tumorigenesis. Michael Rangel, Jerry Kong, +2 authors, Vrushank Bhatt, Khoosheh Khayati, Jessie Yanxiang Guo. less FEBS J, 2021 Jul 17;. PMID: 34270851 Free PMC article. Review.
The Crossroads of Periodontitis and Oral Squamous Cell Carcinoma: Immune Implications and Tumor Promoting Capacities. Omnia Elebyary, Abdelahhad Barbour, +2 authors, Noah Fine, Howard C Tenenbaum, Michael Glogauer. less Front Oral Health, 2022 Jan 21; 1. PMID: 35047982 Free PMC article. Review.
A Comparative and Comprehensive Review of Antibody Applications in the Treatment of Lung Disease. Yuefeng Wu, Hai Song. Life (Basel), 2022 Jan 22; 12(1). PMID: 35054524 Free PMC article. Review.
Back to the Future: Spatiotemporal Determinants of NK Cell Antitumor Function. Joey H Li, Timothy E O'Sullivan. Front Immunol, 2022 Jan 28; 12. PMID: 35082797 Free PMC article. Review.
Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect. Yu-Ling Bin, Hong-Sai Hu, +6 authors, De-Feng Li. less Front Oncol, 2022 Feb 01; 11. PMID: 35096565 Free PMC article. Review.
Agrin Promotes Non-Small Cell Lung Cancer Progression and Stimulates Regulatory T Cells via Increasing IL-6 Secretion Through PI3K/AKT Pathway. Linzhi Han, Hongjie Shi, +9 authors, Yan Gong. less Front Oncol, 2022 Feb 04; 11. PMID: 35111682 Free PMC article.
The therapeutic effect of IL-21 combined with IFN-γ inducing CD4+CXCR5+CD57+T cells differentiation on hepatocellular carcinoma. Changlin Zhao, Xianlin Wu, Jia Chen, Guoqiang Qian. J Adv Res, 2022 Feb 08; 36. PMID: 35127167 Free PMC article.
Genetic Changes Driving Immunosuppressive Microenvironments in Oral Premalignancy. Roberto Rangel, Curtis R Pickering, Andrew G Sikora, Michael T Spiotto. Front Immunol, 2022 Feb 15; 13. PMID: 35154165 Free PMC article. Review.
Characterization of Immunoactive and Immunotolerant CD4+ T Cells in Breast Cancer by Measuring Activity of Signaling Pathways That Determine Immune Cell Function. Yvonne Wesseling-Rozendaal, Arie van Doorn, Karen Willard-Gallo, Anja van de Stolpe. Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158758 Free PMC article.
Chemokine Receptor-Targeted Therapies: Special Case for CCR8. Bernhard Moser. Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158783 Free PMC article. Review.
Identification and Quantification of Necroptosis Landscape on Therapy and Prognosis in Kidney Renal Clear Cell Carcinoma. Sheng Xin, Jiaquan Mao, +11 authors, Xiaodong Song. less Front Genet, 2022 Mar 04; 13. PMID: 35237304 Free PMC article.
Anti-Tumor Potency of Short-Term Interleukin-15 Dendritic Cells Is Potentiated by In Situ Silencing of Programmed-Death Ligands. Maarten Versteven, Donovan Flumens, +10 authors, Eva Lion. less Front Immunol, 2022 Mar 08; 13. PMID: 35250967 Free PMC article.
Antagonistic Antibody Targeting TNFR2 Inhibits Regulatory T Cell Function to Promote Anti-Tumor Activity. Yonglin Chen, Manxue Jia, +2 authors, Sharon Wang, Sherry Xu, Nanhai He. less Front Immunol, 2022 Mar 08; 13. PMID: 35251028 Free PMC article.
Targeting TNFR2 in Cancer: All Roads Lead to Rome. Jingchao Bai, Bowen Ding, Hui Li. Front Immunol, 2022 Mar 08; 13. PMID: 35251045 Free PMC article. Review.
Immune Status and Chemokine C Receptor 7 Expression in Primary in Patients with Immune Thrombocytopenia Lin Zhang, Guo-zhong Zhou, Wei-ying Feng, Dan Li. Turk J Haematol, 2021 Aug 28; 39(1). PMID: 34445858 Free PMC article.
Regulatory T Cells in Autoimmune Vasculitis. Ke Jin, Simon Parreau, +4 authors, Cornelia M Weyand. less Front Immunol, 2022 Mar 18; 13. PMID: 35296082 Free PMC article. Review.
Nasopharyngeal Carcinoma and Its Microenvironment: Past, Current, and Future Perspectives. Zhi Yi Su, Pui Yan Siak, Chee-Onn Leong, Shiau-Chuen Cheah. Front Oncol, 2022 Mar 22; 12. PMID: 35311066 Free PMC article. Review.
Vitiligo-specific soluble biomarkers as early indicators of response to immune checkpoint inhibitors in metastatic melanoma patients. Maria Luigia Carbone, Gabriele Madonna, +10 authors, Cristina Maria Failla. less Sci Rep, 2022 Apr 02; 12(1). PMID: 35361879 Free PMC article.
The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer. Miya Haruna, Azumi Ueyama, +13 authors, Hisashi Wada. less Sci Rep, 2022 Apr 01; 12(1). PMID: 35354899 Free PMC article.
CIMT 2021: report on the 18th Annual Meeting of the Association for Cancer Immunotherapy. Arne Billmeier, Krutika Khinvasara, +5 authors, Mustafa Diken. less Hum Vaccin Immunother, 2022 Feb 08; 18(1). PMID: 35130105 Free PMC article.
Regulatory T cells (Tregs) and their therapeutic potential against autoimmune disorders - Advances and challenges. Tapas Kumar Goswami, Mithilesh Singh, +7 authors, Kuldeep Dhama. less Hum Vaccin Immunother, 2022 Mar 05; 18(1). PMID: 35240914 Free PMC article. Review.
Association of Elevated Expression Levels of COL4A1 in Stromal Cells with an Immunosuppressive Tumor Microenvironment in Low-Grade Glioma, Pancreatic Adenocarcinoma, Skin Cutaneous Melanoma, and Stomach Adenocarcinoma. Hyo-Jae Shin, Minchan Gil, Im-Soon Lee. J Pers Med, 2022 Apr 24; 12(4). PMID: 35455650 Free PMC article.
Immunotherapy Mechanism of Esophageal Squamous Cell Carcinoma with the Effect of STK11/AMPK Signaling Pathway. Yang Xia, Peng Wang, +4 authors, Gaohua Han. less Biomed Res Int, 2022 Apr 26; 2022. PMID: 35463992 Free PMC article.
Neutrophils and polymorphonuclear myeloid-derived suppressor cells: an emerging battleground in cancer therapy. Hans Raskov, Adile Orhan, Shruti Gaggar, Ismail Gögenur. Oncogenesis, 2022 May 04; 11(1). PMID: 35504900 Free PMC article. Review.
Immune effects of CDK4/6 inhibitors in patients with HR+/HER2- metastatic breast cancer: Relief from immunosuppression is associated with clinical response. Fabio Scirocchi, Simone Scagnoli, +9 authors, Marianna Nuti. less EBioMedicine, 2022 Apr 28; 79. PMID: 35477069 Free PMC article.
Comprehensive Analysis of 5-Methylcytosine (m5C) Regulators and the Immune Microenvironment in Pancreatic Adenocarcinoma to Aid Immunotherapy. Ronglin Wang, Yongdong Guo, +12 authors, Haichuan Su. less Front Oncol, 2022 Apr 19; 12. PMID: 35433474 Free PMC article.
The Role of NRF2/KEAP1 Pathway in Glioblastoma: Pharmacological Implications. Seyed Hossein Shahcheraghi, Fateme Salemi, +4 authors, Marzieh Lotfi. less Med Oncol, 2022 May 15; 39(5). PMID: 35568790 Review.
Hypoxia as a Modulator of Inflammation and Immune Response in Cancer. Rosa A Castillo-Rodríguez, Cristina Trejo-Solís, +2 authors, Víctor Manuel Dávila-Borja. less Cancers (Basel), 2022 May 15; 14(9). PMID: 35565420 Free PMC article. Review.
Sodium Tanshinone IIA Sulfonate as a Potent IDO1/TDO2 Dual Inhibitor Enhances Anti-PD1 Therapy for Colorectal Cancer in Mice. Rongjie Zhang, Yuanfeiyi Wang, +4 authors, Wenshuang Wu. less Front Pharmacol, 2022 May 17; 13. PMID: 35571116 Free PMC article.
The dark side of immunotherapy: pancreatic cancer. Gianluca Mucciolo, Cecilia Roux, +3 authors, Paola Cappello. less Cancer Drug Resist, 2020 May 11; 3(3). PMID: 35582441 Free PMC article. Review.

BioKDE: Biomedical Knowledge Discovery Engine

Abstract

Other Links