Journal Article
. 1987 Oct; 238(4823):75-8.
doi: 10.1126/science.3116668.

The IL-2 receptor beta chain (p70): role in mediating signals for LAK, NK, and proliferative activities

J P Siegel 1 M Sharon  P L Smith  W J Leonard  
  • PMID: 3116668
  •     101 citations


Interleukin-2 (IL-2) induces cytolytic activity and proliferation of human blood lymphocytes. Yet, prior to activation, these cells do not express IL-2 receptors recognized by monoclonal antibodies to the Tac antigen. A novel glycoprotein (IL-2R beta), identified on several lymphocytoid cell lines, has the ability to bind IL-2 alone and to associate with Tac antigen (IL-2R alpha) to form high-affinity IL-2 receptors. It is now reported that IL-2R beta is expressed on both circulating T lymphocytes and large granular lymphocytes in quantities approximately proportional to their responsiveness to IL-2. Studies of the responses of these cells to IL-2 suggest that IL-2R beta mediates the initial phase of induction of lymphokine activated killer (LAK), natural killer (NK), and proliferative activities. Subsequently, IL-2R alpha is induced and functional high-affinity IL-2 receptors are expressed.

Leukotriene B4 augments interleukin-2 receptor-beta (IL-2R beta) expression and IL-2R beta-mediated cytotoxic response in human peripheral blood lymphocytes.
J Stanková, N Gagnon, M Rola-Pleszczynski.
Immunology, 1992 Jun 01; 76(2). PMID: 1321793    Free PMC article.
Role and regulation of interleukin (IL)-2 receptor alpha and beta chains in IL-2-driven B-cell growth.
K Nakanishi, S Hirose, +7 authors, K Higashino.
Proc Natl Acad Sci U S A, 1992 Apr 15; 89(8). PMID: 1373502    Free PMC article.
Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.
V Calvo, C M Crews, T A Vik, B E Bierer.
Proc Natl Acad Sci U S A, 1992 Aug 15; 89(16). PMID: 1380162    Free PMC article.
Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line.
L Karnitz, S L Sutor, +5 authors, R T Abraham.
Mol Cell Biol, 1992 Oct 01; 12(10). PMID: 1406641    Free PMC article.
The CySF-L2 factor from dialysable human leucocyte extract activates natural killer cytotoxicity by induction of interferon gamma.
I Doelker, F A Anderer.
Cancer Immunol Immunother, 1992 Jan 01; 34(5). PMID: 1540976
c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor beta chain.
M Hatakeyama, A Kawahara, +2 authors, T Taniguchi.
Proc Natl Acad Sci U S A, 1992 Mar 15; 89(6). PMID: 1549560    Free PMC article.
Interleukin (IL)-2 and IL-3 induce distinct but overlapping responses in murine IL-3-dependent 32D cells transduced with human IL-2 receptor beta chain: involvement of tyrosine kinase(s) other than p56lck.
H Otani, J P Siegel, +7 authors, W J Leonard.
Proc Natl Acad Sci U S A, 1992 Apr 01; 89(7). PMID: 1557384    Free PMC article.
Mycobacterial induction of activated killer cells: possible role of tyrosine kinase activity in interleukin-2 receptor alpha expression.
D K Blanchard, S McMillen, S L Hoffman, J Y Djeu.
Infect Immun, 1992 Jul 01; 60(7). PMID: 1612749    Free PMC article.
Production of granulocyte/macrophage-colony-stimulating factor by human natural killer cells. Modulation by the p75 subunit of the interleukin 2 receptor and by the CD2 receptor.
L J Levitt, A Nagler, +3 authors, D Thompson.
J Clin Invest, 1991 Jul 01; 88(1). PMID: 1676038    Free PMC article.
IL-1 and IL-4 as reciprocal regulators of IL-2 induced lymphocyte cytotoxicity.
N Ebina, D Gallardo, H Shau, S H Golub.
Br J Cancer, 1990 Oct 01; 62(4). PMID: 1699593    Free PMC article.
Endogenous interferon alpha/beta produced by Kupffer cells inhibits interleukin-1, tumor necrosis factor alpha production and interleukin-2-induced activation of nonparenchymal liver cells.
S P Tzung, S A Cohen.
Cancer Immunol Immunother, 1991 Jan 01; 34(3). PMID: 1756531
Differential regulation of lymphokine production by distinct subunits of the T cell interleukin 2 receptor.
S Burdach, N Zessack, +3 authors, L Levitt.
J Clin Invest, 1991 Jun 01; 87(6). PMID: 1828253    Free PMC article.
Preferential expression of IL-2 receptor subunits on memory populations within CD4+ and CD8+ T cells.
K Taga, Y Kasahara, +2 authors, N Taniguchi.
Immunology, 1991 Jan 01; 72(1). PMID: 1900055    Free PMC article.
Effect of swainsonine on interleukin-2 alpha chain receptor expression and proliferation of human lymphocytes.
A Myc, P DeAngelis, +2 authors, Z Darzynkiewicz.
Clin Exp Immunol, 1991 Jun 01; 84(3). PMID: 1904326    Free PMC article.
The integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction.
T Miyazaki, M Maruyama, +2 authors, T Taniguchi.
EMBO J, 1991 Nov 01; 10(11). PMID: 1915291    Free PMC article.
T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck.
I D Horak, R E Gress, +3 authors, J B Bolen.
Proc Natl Acad Sci U S A, 1991 Mar 01; 88(5). PMID: 2000405    Free PMC article.
Ligand-stimulated tyrosine phosphorylation of the IL-2 receptor beta chain and receptor-associated proteins.
D A Shackelford, I S Trowbridge.
Cell Regul, 1991 Jan 01; 2(1). PMID: 2007186    Free PMC article.
Localization in human interleukin 2 of the binding site to the alpha chain (p55) of the interleukin 2 receptor.
K Sauvé, M Nachman, +6 authors, G Ju.
Proc Natl Acad Sci U S A, 1991 Jun 01; 88(11). PMID: 2052547    Free PMC article.
Flow cytometry resonance energy transfer suggests an association between low-affinity interleukin 2 binding sites and HLA class I molecules.
A Harel-Bellan, P Krief, +2 authors, Z Mishal.
Biochem J, 1990 May 15; 268(1). PMID: 2111701    Free PMC article.
Interleukin 2, soluble interleukin 2 receptor, and interferon-gamma in the suction blister fluids from psoriatic skin.
H Takematsu, H Tagami.
Arch Dermatol Res, 1990 Jan 01; 282(3). PMID: 2114831
Interleukin-2 receptor beta-chain (p70-75) expressed on leukemic cells from adult T cell leukemia patients.
T Kodaka, T Uchiyama, +7 authors, K Araki.
Jpn J Cancer Res, 1990 Sep 01; 81(9). PMID: 2121691    Free PMC article.
Suppression of lymphokine-activated killer (LAK) cell induction mediated by interleukin-4 and transforming growth factor-beta 1: effect of addition of exogenous tumour necrosis factor-alpha and interferon-gamma, and measurement of their endogenous production.
B Brooks, K Chapman, +2 authors, R C Rees.
Clin Exp Immunol, 1990 Dec 01; 82(3). PMID: 2124961    Free PMC article.
Expression of interleukin-2 receptor on blood lymphocytes stimulated with allogeneic lymphocytes or autologous tumor cells. The mixed lymphocyte culture of allo-sensitized individuals and the auto-tumor stimulation show similar kinetics of activation.
G Stuber, F Vánky, +2 authors, E Klein.
Cancer Immunol Immunother, 1990 Jan 01; 31(2). PMID: 2138932
Anti-interleukin 2 receptor antibody attenuates low-dose streptozotocin-induced diabetes in mice.
N Hatamori, K Yokono, +7 authors, S Baba.
Diabetologia, 1990 May 01; 33(5). PMID: 2142923
Murine interleukin 2 receptor beta chain: dysregulated gene expression in lymphoma line EL-4 caused by a promoter insertion.
T Kono, T Doi, +6 authors, T Taniguchi.
Proc Natl Acad Sci U S A, 1990 Mar 01; 87(5). PMID: 2155425    Free PMC article.
cDNA cloning of ovine interleukin 2 by PCR.
J C Goodall, D C Emery, +2 authors, L Hall.
Nucleic Acids Res, 1990 Oct 11; 18(19). PMID: 2216781    Free PMC article.
Interleukin-2-dependent long-term cultures of low-density lymphocytes allow the proliferation of lymphokine-activated killer cells with natural killer, Ti gamma/delta or TNK phenotype.
U Testa, A Care, +7 authors, G Isacchi.
Cancer Immunol Immunother, 1990 Jan 01; 31(1). PMID: 2306752
Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences.
J R Gnarra, H Otani, +3 authors, W J Leonard.
Proc Natl Acad Sci U S A, 1990 May 01; 87(9). PMID: 2333293    Free PMC article.
A 100-kilodalton protein is associated with the murine interleukin 2 receptor: biochemical evidence that p100 is distinct from the alpha and beta chains.
M Sharon, J R Gnarra, W J Leonard.
Proc Natl Acad Sci U S A, 1990 Jun 01; 87(12). PMID: 2352954    Free PMC article.
Cancer, cytokines, and cytotoxic cells: interleukin-2 in the immunotherapy of human neoplasms.
J Atzpodien, H Kirchner.
Klin Wochenschr, 1990 Jan 04; 68(1). PMID: 2407894
Mitogenicity and down-regulation of high-affinity interleukin 2 receptor by YTA-1 and YTA-2, monoclonal antibodies that recognize 75-kDa molecules on human large granular lymphocytes.
Y Nakamura, T Inamoto, +6 authors, J Yodoi.
Proc Natl Acad Sci U S A, 1989 Feb 01; 86(4). PMID: 2465549    Free PMC article.
Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies.
M Tsudo, F Kitamura, M Miyasaka.
Proc Natl Acad Sci U S A, 1989 Mar 01; 86(6). PMID: 2467293    Free PMC article.
Highly Cited.
Interleukin-2 can induce suppression of human natural killer cell cytotoxicity.
K Hellstrand, S Hermodsson.
Clin Exp Immunol, 1989 Sep 01; 77(3). PMID: 2509116    Free PMC article.
Adoptive immunotherapy with interleukin-2 (IL-2) results in diminished IL-2 production by stimulated peripheral blood lymphocytes.
R Kradin, J Kurnick, +3 authors, D Lazarus.
J Clin Immunol, 1989 Sep 01; 9(5). PMID: 2533598
Activation of peripheral blood T cells via the p75 interleukin 2 receptor.
H Yagita, M Nakata, +4 authors, K Okumura.
J Exp Med, 1989 Oct 01; 170(4). PMID: 2571670    Free PMC article.
Augmentative effect of Nocardia rubra cell-wall skeleton on the induction of human lymphokine-activated killer (LAK) cells by the production of LAK cell helper factor(s).
T Shirasaka, I Kawase, +7 authors, S Kishimoto.
Cancer Immunol Immunother, 1989 Jan 01; 30(4). PMID: 2598189
Lymphokine activated killer cells.
A Lindemann, F Herrmann, W Oster, R Mertelsmann.
Blut, 1989 Oct 01; 59(4). PMID: 2676022
The role of interleukin 2 in the regulation of proliferation and IgM synthesis of human newborn mononuclear cells.
J Punnonen.
Clin Exp Immunol, 1989 Mar 01; 75(3). PMID: 2784745    Free PMC article.
Serum levels of the low-affinity interleukin-2 receptor molecule (TAC) during IL-2 therapy reflect systemic lymphoid mass activation.
S D Voss, J A Hank, +3 authors, P M Sondel.
Cancer Immunol Immunother, 1989 Jan 01; 29(4). PMID: 2787694
Expression of novel interleukin 2 binding molecules and their functional roles in human B cell differentiation.
T Tanaka, O Saiki, +3 authors, S Kishimoto.
J Clin Invest, 1988 Jul 01; 82(1). PMID: 2839549    Free PMC article.
Surface proteins and glycoproteins of human leucocytes.
V Horejsí, V Bazil.
Biochem J, 1988 Jul 01; 253(1). PMID: 3048251    Free PMC article.
Identification of specific residues of human interleukin 2 that affect binding to the 70-kDa subunit (p70) of the interleukin 2 receptor.
L Collins, W H Tsien, +7 authors, G Ju.
Proc Natl Acad Sci U S A, 1988 Oct 01; 85(20). PMID: 3051003    Free PMC article.
The interleukins in acquired disease.
M Malkovský, P M Sondel, W Strober, A G Dalgleish.
Clin Exp Immunol, 1988 Nov 01; 74(2). PMID: 3066538    Free PMC article.
Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors.
J E Nagel, R K Chopra, +4 authors, W H Adler.
J Clin Invest, 1988 Apr 01; 81(4). PMID: 3127423    Free PMC article.
Membrane-bound/soluble IL-2 receptor (IL-2R) and levels of IL-1 alpha, IL-2, and IL-6 in the serum and in the PBMC culture supernatants from 17 patients with hematological malignancies.
G Mantovani, A Macciò, +3 authors, G S Del Giacco.
Cell Biophys, 1995 Aug 01; 27(1). PMID: 7493395
IL-2 and IL-7 but not IL-12 protect natural killer cells from death by apoptosis and up-regulate bcl-2 expression.
M Armant, G Delespesse, M Sarfati.
Immunology, 1995 Jun 01; 85(2). PMID: 7642225    Free PMC article.
Selective modulation of human natural killer cells in vivo after prolonged infusion of low dose recombinant interleukin 2.
M A Caligiuri, C Murray, +7 authors, R J Soiffer.
J Clin Invest, 1993 Jan 01; 91(1). PMID: 7678599    Free PMC article.
Murine T-lymphocyte proliferation induced by interleukin 2 correlates with a transient increase in p56lck kinase activity and the tyrosine phosphorylation of a 97-kDa protein.
Y H Kim, M J Buchholz, A A Nordin.
Proc Natl Acad Sci U S A, 1993 Apr 15; 90(8). PMID: 7682694    Free PMC article.
Coexpression of Fc gamma receptor IIIA and interleukin-2 receptor beta chain by a subset of human CD3+/CD8+/CD11b+ lymphocytes.
S Zupo, L Azzoni, +3 authors, M Ferrarini.
J Clin Immunol, 1993 May 01; 13(3). PMID: 7686565
Phenotypic knockout of the high-affinity human interleukin 2 receptor by intracellular single-chain antibodies against the alpha subunit of the receptor.
J H Richardson, J G Sodroski, T A Waldmann, W A Marasco.
Proc Natl Acad Sci U S A, 1995 Apr 11; 92(8). PMID: 7724529    Free PMC article.
Induction of tumor-specific cytotoxic T lymphocytes and natural killer cells by tumor cells transfected with the interleukin-2 gene.
Y Iwanuma, K Kato, H Yagita, K Okumura.
Cancer Immunol Immunother, 1995 Jan 01; 40(1). PMID: 7828164
Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines.
A Greenway, A Azad, D McPhee.
J Virol, 1995 Mar 01; 69(3). PMID: 7853525    Free PMC article.
Exercise and the immune system. Natural killer cells, interleukins and related responses.
R J Shephard, S Rhind, P N Shek.
Sports Med, 1994 Nov 01; 18(5). PMID: 7871295
Membrane-bound and soluble IL-2 receptors (p55 and p75 chains) on peripheral blood mononuclear cells from patients with solid malignancies.
G Mantovani, A Macciò, +7 authors, G Pusceddu.
Cell Biophys, 1993 Jan 01; 22(1-3). PMID: 7889544
Clinical and immunological effects of human recombinant interleukin-2 given by repetitive weekly infusion to normal dogs.
S C Helfand, S A Soergel, +2 authors, P M Sondel.
Cancer Immunol Immunother, 1994 Aug 01; 39(2). PMID: 8044833
Expression of p75 chain of IL-2 receptor in the early immunological reconstitution after allogeneic bone marrow transplantation.
P Comoli, R Maccario, +5 authors, F Locatelli.
Clin Exp Immunol, 1994 Sep 01; 97(3). PMID: 8082308    Free PMC article.
Effect of interleukin 2 on intractable herpes virus infection and chronic eczematoid dermatitis in a patient with Wiskott-Aldrich syndrome.
H Azuma, H Sakata, M Saijyou, A Okuno.
Eur J Pediatr, 1993 Dec 01; 152(12). PMID: 8131820
Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.
X Cao, C A Kozak, +3 authors, W J Leonard.
Proc Natl Acad Sci U S A, 1993 Sep 15; 90(18). PMID: 8378320    Free PMC article.
Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products.
J X Lin, N K Bhat, +2 authors, W J Leonard.
Mol Cell Biol, 1993 Oct 01; 13(10). PMID: 8413220    Free PMC article.
Interleukin-2 in cancer treatment: disappointing or (still) promising? A review.
R A Maas, H F Dullens, W Den Otter.
Cancer Immunol Immunother, 1993 Jan 01; 36(3). PMID: 8439974
Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck.
Y Minami, T Kono, +4 authors, T Taniguchi.
EMBO J, 1993 Feb 01; 12(2). PMID: 8440263    Free PMC article.
Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes.
P Loetscher, M Seitz, M Baggiolini, B Moser.
J Exp Med, 1996 Aug 01; 184(2). PMID: 8760810    Free PMC article.
Highly Cited.
Clonal and functional analysis for the augmentation of tumour-infiltrating lymphocytes by interleukin 4.
T Tsunoda, H Tanimura, +6 authors, K Arii.
Br J Cancer, 1996 Oct 01; 74(7). PMID: 8855979    Free PMC article.
An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.
S John, C M Robbins, W J Leonard.
EMBO J, 1996 Oct 15; 15(20). PMID: 8896456    Free PMC article.
Induction by interleukin-15 of human killer cell activity against lung cancer cell lines and its regulatory mechanisms.
E Takeuchi, H Yanagawa, +2 authors, S Sone.
Jpn J Cancer Res, 1996 Dec 01; 87(12). PMID: 9045960    Free PMC article.
The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor beta-chain promoter through noncanonical Egr and Sp1 binding sites.
J X Lin, W J Leonard.
Mol Cell Biol, 1997 Jul 01; 17(7). PMID: 9199305    Free PMC article.
Combination therapy with antibody and interleukin-2 gene transfer against multidrug-resistant cancer cells.
T Shinohara, Y Sugimoto, +2 authors, T Tsuruo.
Jpn J Cancer Res, 1998 Jan 24; 88(11). PMID: 9439686    Free PMC article.
Effects of immunization with tumor cells double transfected with interleukin-2 (IL-2) and interleukin-12 (IL-12) genes on artificial metastasis of colon26 cells in BALB/c mice.
T Takada, K Kato, +2 authors, K Okumura.
Clin Exp Metastasis, 1999 Jul 20; 17(2). PMID: 10411104
Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors.
A Rebollo, L Dumoutier, +3 authors, C Martínez-A.
Mol Cell Biol, 2000 Apr 25; 20(10). PMID: 10779330    Free PMC article.
Biological significance of soluble IL-2 receptor.
C Caruso, G Candore, +2 authors, M A Modica.
Mediators Inflamm, 1993 Jan 01; 2(1). PMID: 18475497    Free PMC article.
Late expression of granulysin by microbicidal CD4+ T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients.
Chun Fu Zheng, Gareth J Jones, +8 authors, Christopher H Mody.
J Immunol, 2008 May 21; 180(11). PMID: 18490721    Free PMC article.
The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation.
Zheng Wu, Hai-Hui Xue, +7 authors, Warren J Leonard.
Blood, 2008 Sep 18; 112(12). PMID: 18796634    Free PMC article.
Immunotoxicity monitoring of hospital staff occupationally exposed to cytostatic drugs.
Anna Biró, Zoltán Fodor, Jeno Major, Anna Tompa.
Pathol Oncol Res, 2010 Nov 30; 17(2). PMID: 21113743
IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation.
Wei Liao, Jian-Xin Lin, Warren J Leonard.
Curr Opin Immunol, 2011 Sep 06; 23(5). PMID: 21889323    Free PMC article.
Highly Cited. Review.
Early effects of low dose C ion or x-ray irradiation on peripheral blood lymphocytes of patients with alimentary tract cancer.
Yingtai Chen, Xuezhong Chen, +13 authors, Yawei Zhang.
Dose Response, 2011 Oct 21; 9(3). PMID: 22013398    Free PMC article.
Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy.
Wei Liao, Jian-Xin Lin, Warren J Leonard.
Immunity, 2013 Jan 29; 38(1). PMID: 23352221    Free PMC article.
Highly Cited. Review.
Pulmonary manifestations in Behçet disease: impaired natural killer cells activity.
Kamel Hamzaoui, Anissa Berraies, +2 authors, Agnès Hamzaoui.
Multidiscip Respir Med, 2013 Apr 06; 8(1). PMID: 23556512    Free PMC article.
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases.
James W Verbsky, Talal A Chatila.
Curr Opin Pediatr, 2013 Nov 19; 25(6). PMID: 24240290    Free PMC article.
Activated T cells secrete an alternatively spliced form of common γ-chain that inhibits cytokine signaling and exacerbates inflammation.
Changwan Hong, Megan A Luckey, +11 authors, Jung-Hyun Park.
Immunity, 2014 Jun 10; 40(6). PMID: 24909888    Free PMC article.
Targeting CD8+ T-cell tolerance for cancer immunotherapy.
Stephanie R Jackson, Jinyun Yuan, Ryan M Teague.
Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416    Free PMC article.
NK cell-based immunotherapies in Pediatric Oncology.
Kimberly A McDowell, Jacquelyn A Hank, +3 authors, Paul M Sondel.
J Pediatr Hematol Oncol, 2015 Jan 16; 37(2). PMID: 25590232    Free PMC article.
The role of soluble common gamma chain in autoimmune disease.
Byunghyuk Lee, Changwan Hong.
Anat Cell Biol, 2015 Mar 26; 48(1). PMID: 25806117    Free PMC article.
Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.
Jamie B Spangler, Jakub Tomala, +7 authors, K Christopher Garcia.
Immunity, 2015 May 21; 42(5). PMID: 25992858    Free PMC article.
Highly Cited.
Common gamma chain cytokines in combinatorial immune strategies against cancer.
Stephanie R Pulliam, Roman V Uzhachenko, Samuel E Adunyah, Anil Shanker.
Immunol Lett, 2015 Nov 26; 169. PMID: 26597610    Free PMC article.
Interleukin-2-regulatory T cell axis critically regulates maintenance of hematopoietic stem cells.
Sabrina Giampaolo, Gabriela Wójcik, Edgar Serfling, Amiya K Patra.
Oncotarget, 2017 Apr 19; 8(18). PMID: 28415569    Free PMC article.
Human Articular Chondrocytes Induce Interleukin-2 Nonresponsiveness to Allogeneic Lymphocytes.
Satomi Abe, Hitoshi Nochi, Hiroshi Ito.
Cartilage, 2017 Jun 18; 8(3). PMID: 28618867    Free PMC article.
Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4+ T cells.
Eunkyeong Jang, Hye Rim Lee, +4 authors, Jeehee Youn.
BMB Rep, 2017 Sep 01; 50(9). PMID: 28855027    Free PMC article.
Tumor-related interleukins: old validated targets for new anti-cancer drug development.
Sarra Setrerrahmane, Hanmei Xu.
Mol Cancer, 2017 Sep 21; 16(1). PMID: 28927416    Free PMC article.
Prospects of IL-2 in Cancer Immunotherapy.
Hani Choudhry, Nawal Helmi, +7 authors, Mohammad S Jamal.
Biomed Res Int, 2018 Jun 02; 2018. PMID: 29854806    Free PMC article.
IL-2 Inhibition of Th17 Generation Rather Than Induction of Treg Cells Is Impaired in Primary Sjögren's Syndrome Patients.
Jing Luo, Bingxia Ming, +11 authors, Lingli Dong.
Front Immunol, 2018 Aug 29; 9. PMID: 30150979    Free PMC article.
Improved islet recovery and efficacy through co-culture and co-transplantation of islets with human adipose-derived mesenchymal stem cells.
Anissa Gamble, Rena Pawlick, +5 authors, A M James Shapiro.
PLoS One, 2018 Nov 13; 13(11). PMID: 30419033    Free PMC article.
In vivo immunogenicity assessment and vaccine efficacy evaluation of a chimeric tandem repeat of epitopic region of OMP31 antigen fused to interleukin 2 (IL-2) against Brucella melitensis in BALB/c mice.
Narges Nazifi, Mojtaba Tahmoorespur, +2 authors, Ali Mohammad Behroozikhah.
BMC Vet Res, 2019 Nov 11; 15(1). PMID: 31703683    Free PMC article.
Role of cytokine agonists and immune checkpoint inhibitors toward HIV remission.
Timothy N Hoang, Mirko Paiardini.
Curr Opin HIV AIDS, 2018 Dec 27; 14(2). PMID: 30585798    Free PMC article.
Biology of natural killer cells.
G Trinchieri.
Adv Immunol, 1989 Jan 01; 47. PMID: 2683611    Free PMC article.
Highly Cited. Review.
The Common Cytokine Receptor γ Chain Family of Cytokines.
Jian-Xin Lin, Warren J Leonard.
Cold Spring Harb Perspect Biol, 2017 Oct 19; 10(9). PMID: 29038115    Free PMC article.
Treg cell-based therapies: challenges and perspectives.
Caroline Raffin, Linda T Vo, Jeffrey A Bluestone.
Nat Rev Immunol, 2019 Dec 08; 20(3). PMID: 31811270    Free PMC article.
Integration of IL-2 and IL-4 signals coordinates divergent regulatory T cell responses and drives therapeutic efficacy.
Julie Y Zhou, Carlos A Alvarez, Brian A Cobb.
Elife, 2021 Feb 23; 10. PMID: 33617447    Free PMC article.
Depression Induced by CUMS Leads to Bladder Cancer Development and Local Tumor Immunosuppression in Mice.
Zhiyu Qian, Weihong Ding, +2 authors, Ke Xu.
J Oncol, 2021 Aug 24; 2021. PMID: 34422050    Free PMC article.
Duplication of the IL2RA locus causes excessive IL-2 signaling and may predispose to very early onset colitis.
Maria E Joosse, Fabienne Charbit-Henrion, +14 authors, Janneke N Samsom.
Mucosal Immunol, 2021 Jul 07; 14(5). PMID: 34226674    Free PMC article.
Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy.
Dongyao Wang, Binqing Fu, +8 authors, Haiming Wei.
Signal Transduct Target Ther, 2021 Nov 06; 6(1). PMID: 34737296    Free PMC article.
Evaluation of Immunoprotective Effects of Fusobacterium necrophorum Outer Membrane Proteins 43K OMP, Leukotoxin and Hemolysin Multi-Component Recombinant Subunit Vaccine in Mice.
Jiawei Xiao, Jiancheng Jiang, +5 authors, Donghua Guo.
Front Vet Sci, 2021 Dec 24; 8. PMID: 34938794    Free PMC article.