. 2019 Jun; 143:255-294.
doi: 10.1016/bs.acr.2019.03.005.

Impact of the microbiome on cancer progression and response to anti-cancer therapies

Claire Buchta Rosean 1 Tzu-Yu Feng 1 Francesca N Azar 1 Melanie R Rutkowski 2 
  • PMID: 31202360
  •     183 References
  •     9 citations


Humans are a colonized with trillions of commensal microorganisms which exert a profound effect on normal host physiology and immune function through an abundance of genetic and metabolic by-products. Although the commensal microbiome has beneficial functions to host physiology, perturbations of the composition of the commensal microbiome or the homeostatic mucosal environment can lead to the induction of immune pathology and systemic inflammation. In the context of cancer progression or response to immune therapy, this inflammation can be detrimental, resulting in tumor growth and the promotion of immune suppression. On the other hand, significant associations have been identified whereby certain commensal microorganisms are able to enhance T cell function or are required for tumor control in cancer patients treated with certain immune therapies and chemotherapies. The focus of this chapter is to highlight the role of the commensal microbiome during tumor progression and in response to immune therapies.

Keywords: Cancer; Commensal dysbiosis; Immunosuppression; Immunotherapy; Microbiome.

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PLoS One, 2013 Jan 22; 8(1). PMID: 23335968    Free PMC article.
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V Gopalakrishnan, C N Spencer, +67 authors, J A Wargo.
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N Engl J Med, 2013 Jan 18; 368(5). PMID: 23323867
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Ayelet Sivan, Leticia Corrales, +9 authors, Thomas F Gajewski.
Science, 2015 Nov 07; 350(6264). PMID: 26541606    Free PMC article.
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Cancer Res, 2005 Apr 19; 65(8). PMID: 15833879
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Gastroenterology, 2011 Jun 21; 141(2). PMID: 21683077
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Nat Rev Immunol, 2013 Apr 27; 13(5). PMID: 23618829
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Nat Med, 2010 Jan 19; 16(2). PMID: 20081863    Free PMC article.
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Am J Gastroenterol, 2013 Aug 06; 108(8). PMID: 23912408
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Won Suck Yoon, Won Cheol Choi, Jeong-Im Sin, Yong Keun Park.
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PLoS Biol, 2016 Aug 20; 14(8). PMID: 27541692    Free PMC article.
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Nature, 2013 Aug 30; 500(7464). PMID: 23985870
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Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
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Proc Natl Acad Sci U S A, 2018 Sep 27; 115(41). PMID: 30249647    Free PMC article.
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Exploiting the Metabolism of the Gut Microbiome as a Vehicle for Targeted Drug Delivery to the Colon.
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