Journal Article
. 2019 Jul; 25(8):1301-1309.
doi: 10.1038/s41591-019-0508-1.

Clinical-grade computational pathology using weakly supervised deep learning on whole slide images

Gabriele Campanella 1 Matthew G Hanna 1 Luke Geneslaw 1 Allen Miraflor 1 Vitor Werneck Krauss Silva 1 Klaus J Busam 1 Edi Brogi 1 Victor E Reuter 1 David S Klimstra 1 Thomas J Fuchs 2 
Affiliations
  • PMID: 31308507
  •     28 References
  •     169 citations

Abstract

The development of decision support systems for pathology and their deployment in clinical practice have been hindered by the need for large manually annotated datasets. To overcome this problem, we present a multiple instance learning-based deep learning system that uses only the reported diagnoses as labels for training, thereby avoiding expensive and time-consuming pixel-wise manual annotations. We evaluated this framework at scale on a dataset of 44,732 whole slide images from 15,187 patients without any form of data curation. Tests on prostate cancer, basal cell carcinoma and breast cancer metastases to axillary lymph nodes resulted in areas under the curve above 0.98 for all cancer types. Its clinical application would allow pathologists to exclude 65-75% of slides while retaining 100% sensitivity. Our results show that this system has the ability to train accurate classification models at unprecedented scale, laying the foundation for the deployment of computational decision support systems in clinical practice.

Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning.
Nicolas Coudray, Paolo Santiago Ocampo, +6 authors, Aristotelis Tsirigos.
Nat Med, 2018 Sep 19; 24(10). PMID: 30224757
Highly Cited.
Deep learning.
Yann LeCun, Yoshua Bengio, Geoffrey Hinton.
Nature, 2015 May 29; 521(7553). PMID: 26017442
Highly Cited. Review.
Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer.
Babak Ehteshami Bejnordi, Mitko Veta, +67 authors, Rui Venâncio.
JAMA, 2017 Dec 14; 318(22). PMID: 29234806    Free PMC article.
Highly Cited.
Using deep convolutional neural networks to identify and classify tumor-associated stroma in diagnostic breast biopsies.
Babak Ehteshami Bejnordi, Maeve Mullooly, +11 authors, Mark E Sherman.
Mod Pathol, 2018 Jun 15; 31(10). PMID: 29899550    Free PMC article.
Diagnostic Performance of Deep Learning Algorithms Applied to Three Common Diagnoses in Dermatopathology.
Thomas George Olsen, B Hunter Jackson, +5 authors, Rajath E Soans.
J Pathol Inform, 2018 Oct 09; 9. PMID: 30294501    Free PMC article.
Predicting cancer outcomes from histology and genomics using convolutional networks.
Pooya Mobadersany, Safoora Yousefi, +5 authors, Lee A D Cooper.
Proc Natl Acad Sci U S A, 2018 Mar 14; 115(13). PMID: 29531073    Free PMC article.
Highly Cited.
Intraobserver and interobserver reproducibility of WHO and Gleason histologic grading systems in prostatic adenocarcinomas.
S O Ozdamar, S Sarikaya, +3 authors, S Yildiz.
Int Urol Nephrol, 1996 Jan 01; 28(1). PMID: 8738623
Deep learning based tissue analysis predicts outcome in colorectal cancer.
Dmitrii Bychkov, Nina Linder, +7 authors, Johan Lundin.
Sci Rep, 2018 Feb 23; 8(1). PMID: 29467373    Free PMC article.
Highly Cited.
Cancer statistics, 2016.
Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal.
CA Cancer J Clin, 2016 Jan 09; 66(1). PMID: 26742998
Highly Cited.
Classifying and segmenting microscopy images with deep multiple instance learning.
Oren Z Kraus, Jimmy Lei Ba, Brendan J Frey.
Bioinformatics, 2016 Jun 17; 32(12). PMID: 27307644    Free PMC article.
Highly Cited.
Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.
E R DeLong, D M DeLong, D L Clarke-Pearson.
Biometrics, 1988 Sep 01; 44(3). PMID: 3203132
Highly Cited.
Computational pathology analysis of tissue microarrays predicts survival of renal clear cell carcinoma patients.
Thomas J Fuchs, Peter J Wild, Holger Moch, Joachim M Buhmann.
Med Image Comput Comput Assist Interv, 2008 Nov 06; 11(Pt 2). PMID: 18982583
Deep learning as a tool for increased accuracy and efficiency of histopathological diagnosis.
Geert Litjens, Clara I Sánchez, +7 authors, Jeroen van der Laak.
Sci Rep, 2016 May 24; 6. PMID: 27212078    Free PMC article.
Highly Cited.
Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Carcinomas) in the U.S. Population, 2012.
Howard W Rogers, Martin A Weinstock, Steven R Feldman, Brett M Coldiron.
JAMA Dermatol, 2015 May 01; 151(10). PMID: 25928283
Highly Cited.
Patch-based Convolutional Neural Network for Whole Slide Tissue Image Classification.
Le Hou, Dimitris Samaras, +3 authors, Joel H Saltz.
Proc IEEE Comput Soc Conf Comput Vis Pattern Recognit, 2016 Nov 01; 2016. PMID: 27795661    Free PMC article.
Highly Cited.
Sentinel lymph node biopsy after neoadjuvant chemotherapy for breast cancer: retrospective comparative evaluation of clinically axillary lymph node positive and negative patients, including those with axillary lymph node metastases confirmed by fine needle aspiration.
Yue Yu, Ning Cui, +4 authors, Yuan Sheng.
BMC Cancer, 2016 Oct 21; 16(1). PMID: 27756234    Free PMC article.
Dermatologist-level classification of skin cancer with deep neural networks.
Andre Esteva, Brett Kuprel, +4 authors, Sebastian Thrun.
Nature, 2017 Jan 25; 542(7639). PMID: 28117445    Free PMC article.
Highly Cited.
OpenSlide: A vendor-neutral software foundation for digital pathology.
Adam Goode, Benjamin Gilbert, +2 authors, Mahadev Satyanarayanan.
J Pathol Inform, 2013 Nov 19; 4. PMID: 24244884    Free PMC article.
Metastasis detection from whole slide images using local features and random forests.
Mira Valkonen, Kimmo Kartasalo, +3 authors, Pekka Ruusuvuori.
Cytometry A, 2017 Apr 21; 91(6). PMID: 28426134
A note from history: microscopic contributions of pioneer pathologists.
Steven I Hajdu.
Ann Clin Lab Sci, 2011 Aug 17; 41(2). PMID: 21844582
pROC: an open-source package for R and S+ to analyze and compare ROC curves.
Xavier Robin, Natacha Turck, +4 authors, Markus Müller.
BMC Bioinformatics, 2011 Mar 19; 12. PMID: 21414208    Free PMC article.
Highly Cited.
Prostatic carcinoma reproducibility of histologic grading.
H Svanholm, H Mygind.
Acta Pathol Microbiol Immunol Scand A, 1985 Mar 01; 93(2). PMID: 3984736
Bootstrap confidence intervals: when, which, what? A practical guide for medical statisticians.
J Carpenter, J Bithell.
Stat Med, 2000 May 08; 19(9). PMID: 10797513
Highly Cited.
Computational pathology: challenges and promises for tissue analysis.
Thomas J Fuchs, Joachim M Buhmann.
Comput Med Imaging Graph, 2011 Apr 13; 35(7-8). PMID: 21481567
Deep learning for digital pathology image analysis: A comprehensive tutorial with selected use cases.
Andrew Janowczyk, Anant Madabhushi.
J Pathol Inform, 2016 Aug 27; 7. PMID: 27563488    Free PMC article.
Highly Cited.
Histologic grading of prostate cancer: a perspective.
D F Gleason.
Hum Pathol, 1992 Mar 01; 23(3). PMID: 1555838
Highly Cited. Review.
Computational Pathology: A Path Ahead.
David N Louis, Michael Feldman, +13 authors, Michael J Becich.
Arch Pathol Lab Med, 2015 Jun 23; 140(1). PMID: 26098131    Free PMC article.
Clinically applicable deep learning for diagnosis and referral in retinal disease.
Jeffrey De Fauw, Joseph R Ledsam, +31 authors, Olaf Ronneberger.
Nat Med, 2018 Aug 15; 24(9). PMID: 30104768
Highly Cited.
Connecting Histopathology Imaging and Proteomics in Kidney Cancer through Machine Learning.
Francisco Azuaje, Sang-Yoon Kim, Daniel Perez Hernandez, Gunnar Dittmar.
J Clin Med, 2019 Sep 29; 8(10). PMID: 31557788    Free PMC article.
Prediction of BAP1 Expression in Uveal Melanoma Using Densely-Connected Deep Classification Networks.
Muyi Sun, Wei Zhou, +7 authors, Gustav Stålhammar.
Cancers (Basel), 2019 Oct 19; 11(10). PMID: 31623293    Free PMC article.
Development and validation of deep learning algorithms for scoliosis screening using back images.
Junlin Yang, Kai Zhang, +19 authors, Haotian Lin.
Commun Biol, 2019 Nov 02; 2. PMID: 31667364    Free PMC article.
Deep learning enables pathologist-like scoring of NASH models.
Fabian Heinemann, Gerald Birk, Birgit Stierstorfer.
Sci Rep, 2019 Dec 06; 9(1). PMID: 31804575    Free PMC article.
Machine-based detection and classification for bone marrow aspirate differential counts: initial development focusing on nonneoplastic cells.
Ramraj Chandradevan, Ahmed A Aljudi, +5 authors, David L Jaye.
Lab Invest, 2019 Oct 02; 100(1). PMID: 31570774    Free PMC article.
Resolution-agnostic tissue segmentation in whole-slide histopathology images with convolutional neural networks.
Péter Bándi, Maschenka Balkenhol, +2 authors, Geert Litjens.
PeerJ, 2019 Dec 25; 7. PMID: 31871843    Free PMC article.
Clinical-grade Computational Pathology: Alea Iacta Est.
Filippo Fraggetta.
J Pathol Inform, 2020 Jan 11; 10. PMID: 31921486    Free PMC article.
Precision medicine for human cancers with Notch signaling dysregulation (Review).
Masuko Katoh, Masaru Katoh.
Int J Mol Med, 2020 Jan 03; 45(2). PMID: 31894255    Free PMC article.
Review.
Deep Learning Models for Histopathological Classification of Gastric and Colonic Epithelial Tumours.
Osamu Iizuka, Fahdi Kanavati, +3 authors, Masayuki Tsuneki.
Sci Rep, 2020 Feb 01; 10(1). PMID: 32001752    Free PMC article.
Tailored for Real-World: A Whole Slide Image Classification System Validated on Uncurated Multi-Site Data Emulating the Prospective Pathology Workload.
Julianna D Ianni, Rajath E Soans, +9 authors, Jason B Lee.
Sci Rep, 2020 Feb 23; 10(1). PMID: 32081956    Free PMC article.
Artificial Intelligence in Medicine: Today and Tomorrow.
Giovanni Briganti, Olivier Le Moine.
Front Med (Lausanne), 2020 Mar 03; 7. PMID: 32118012    Free PMC article.
Successful Identification of Nasopharyngeal Carcinoma in Nasopharyngeal Biopsies Using Deep Learning.
Wen-Yu Chuang, Shang-Hung Chang, +12 authors, Chao-Yuan Yeh.
Cancers (Basel), 2020 Feb 27; 12(2). PMID: 32098314    Free PMC article.
Pan-cancer diagnostic consensus through searching archival histopathology images using artificial intelligence.
Shivam Kalra, H R Tizhoosh, +8 authors, Liron Pantanowitz.
NPJ Digit Med, 2020 Mar 21; 3. PMID: 32195366    Free PMC article.
Introduction to digital pathology and computer-aided pathology.
Soojeong Nam, Yosep Chong, +5 authors, Heounjeong Go.
J Pathol Transl Med, 2020 Feb 13; 54(2). PMID: 32045965    Free PMC article.
Review.
Computational analysis of pathological images enables a better diagnosis of TFE3 Xp11.2 translocation renal cell carcinoma.
Jun Cheng, Zhi Han, +7 authors, Jie Zhang.
Nat Commun, 2020 Apr 15; 11(1). PMID: 32286325    Free PMC article.
Artificial intelligence driven next-generation renal histomorphometry.
Briana A Santo, Avi Z Rosenberg, Pinaki Sarder.
Curr Opin Nephrol Hypertens, 2020 Mar 25; 29(3). PMID: 32205581    Free PMC article.
Review.
Assessment of individual tumor buds using keratin immunohistochemistry: moderate interobserver agreement suggests a role for machine learning.
J M Bokhorst, A Blank, +11 authors, I D Nagtegaal.
Mod Pathol, 2019 Dec 18; 33(5). PMID: 31844269    Free PMC article.
Development and Validation of a Deep Learning Model for Non-Small Cell Lung Cancer Survival.
Yunlang She, Zhuochen Jin, +9 authors, Chang Chen.
JAMA Netw Open, 2020 Jun 04; 3(6). PMID: 32492161    Free PMC article.
Weakly-supervised learning for lung carcinoma classification using deep learning.
Fahdi Kanavati, Gouji Toyokawa, +7 authors, Masayuki Tsuneki.
Sci Rep, 2020 Jun 11; 10(1). PMID: 32518413    Free PMC article.
Histologic tissue components provide major cues for machine learning-based prostate cancer detection and grading on prostatectomy specimens.
Wenchao Han, Carol Johnson, +6 authors, Aaron D Ward.
Sci Rep, 2020 Jun 20; 10(1). PMID: 32555410    Free PMC article.
Using artificial intelligence to improve medical services in China.
Ruiyang Li, Yahan Yang, +4 authors, Haotian Lin.
Ann Transl Med, 2020 Jul 04; 8(11). PMID: 32617331    Free PMC article.
Review.
Assessment of associations between clinical and immune microenvironmental factors and tumor mutation burden in resected nonsmall cell lung cancer by applying machine learning to whole-slide images.
Akira Ono, Yukihiro Terada, +17 authors, Toshiaki Takahashi.
Cancer Med, 2020 May 14; 9(13). PMID: 32400056    Free PMC article.
Hyperspectral and multispectral imaging in digital and computational pathology: a systematic review [Invited].
Samuel Ortega, Martin Halicek, +2 authors, Baowei Fei.
Biomed Opt Express, 2020 Jul 09; 11(6). PMID: 32637250    Free PMC article.
Review.
Early triage of critically ill COVID-19 patients using deep learning.
Wenhua Liang, Jianhua Yao, +30 authors, Jianxing He.
Nat Commun, 2020 Jul 17; 11(1). PMID: 32669540    Free PMC article.
Integrating the Tumor Microenvironment into Cancer Therapy.
Sabina Sanegre, Federico Lucantoni, +3 authors, Tomás Álvaro Naranjo.
Cancers (Basel), 2020 Jul 01; 12(6). PMID: 32599891    Free PMC article.
Review.
Development and Validation of a Deep Learning Algorithm for Gleason Grading of Prostate Cancer From Biopsy Specimens.
Kunal Nagpal, Davis Foote, +23 authors, Craig H Mermel.
JAMA Oncol, 2020 Jul 24; 6(9). PMID: 32701148    Free PMC article.
Automatic cancer detection on digital histopathology images of mid-gland radical prostatectomy specimens.
Wenchao Han, Carol Johnson, +7 authors, Aaron D Ward.
J Med Imaging (Bellingham), 2020 Jul 28; 7(4). PMID: 32715024    Free PMC article.
The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma.
Geert J L H van Leenders, Theodorus H van der Kwast, +18 authors, ISUP Grading Workshop Panel Members.
Am J Surg Pathol, 2020 May 28; 44(8). PMID: 32459716    Free PMC article.
Predicting treatment response to neoadjuvant chemoradiotherapy in local advanced rectal cancer by biopsy digital pathology image features.
Fang Zhang, Su Yao, +7 authors, Zaiyi Liu.
Clin Transl Med, 2020 Jul 01; 10(2). PMID: 32594660    Free PMC article.
Digital Pathology and PD-L1 Testing in Non Small Cell Lung Cancer: A Workshop Record.
Fabio Pagni, Umberto Malapelle, +12 authors, Giancarlo Troncone.
Cancers (Basel), 2020 Jul 09; 12(7). PMID: 32635634    Free PMC article.
Notable Papers and Trends from 2019 in Sensors, Signals, and Imaging Informatics.
William Hsu, Christian Baumgartner, Thomas M Deserno, Section Editors for the IMIA Yearbook Section on Sensors, Signals, and Imaging Informatics.
Yearb Med Inform, 2020 Aug 22; 29(1). PMID: 32823307    Free PMC article.
Review.
Cancer Informatics in 2019: Deep Learning Takes Center Stage.
Jeremy L Warner, Debra Patt, Section Editors for the IMIA Yearbook Section on Cancer Informatics.
Yearb Med Inform, 2020 Aug 22; 29(1). PMID: 32823323    Free PMC article.
Review.
Development and Validation of a Deep Learning-Based Model Using Computed Tomography Imaging for Predicting Disease Severity of Coronavirus Disease 2019.
Lu-Shan Xiao, Pu Li, +12 authors, Hong Zhu.
Front Bioeng Biotechnol, 2020 Aug 28; 8. PMID: 32850746    Free PMC article.
Multi-path x-D Recurrent Neural Networks for Collaborative Image Classification.
Riqiang Gao, Yuankai Huo, +8 authors, Bennett A Landman.
Neurocomputing, 2020 Aug 31; 397. PMID: 32863584    Free PMC article.
Impact of rescanning and normalization on convolutional neural network performance in multi-center, whole-slide classification of prostate cancer.
Zaneta Swiderska-Chadaj, Thomas de Bel, +4 authors, Geert Litjens.
Sci Rep, 2020 Sep 03; 10(1). PMID: 32873856    Free PMC article.
Clinically applicable histopathological diagnosis system for gastric cancer detection using deep learning.
Zhigang Song, Shuangmei Zou, +21 authors, Huaiyin Shi.
Nat Commun, 2020 Aug 29; 11(1). PMID: 32855423    Free PMC article.
Radiologist-like artificial intelligence for grade group prediction of radical prostatectomy for reducing upgrading and downgrading from biopsy.
Lizhi Shao, Ye Yan, +16 authors, Jie Tian.
Theranostics, 2020 Sep 16; 10(22). PMID: 32929343    Free PMC article.
Automated detection of cribriform growth patterns in prostate histology images.
Pierre Ambrosini, Eva Hollemans, +3 authors, Frans Vos.
Sci Rep, 2020 Sep 12; 10(1). PMID: 32913202    Free PMC article.
Deep learning quantification of percent steatosis in donor liver biopsy frozen sections.
Lulu Sun, Jon N Marsh, +5 authors, Ta-Chiang Liu.
EBioMedicine, 2020 Sep 28; 60. PMID: 32980688    Free PMC article.
Unsupervised Resolution of Histomorphologic Heterogeneity in Renal Cell Carcinoma Using a Brain Tumor-Educated Neural Network.
Kevin Faust, Adil Roohi, +7 authors, Phedias Diamandis.
JCO Clin Cancer Inform, 2020 Sep 19; 4. PMID: 32946287    Free PMC article.
Deep Learning to Estimate Human Epidermal Growth Factor Receptor 2 Status from Hematoxylin and Eosin-Stained Breast Tissue Images.
Deepak Anand, Nikhil Cherian Kurian, +4 authors, Amit Sethi.
J Pathol Inform, 2020 Oct 10; 11. PMID: 33033656    Free PMC article.
Development and interpretation of a pathomics-based model for the prediction of microsatellite instability in Colorectal Cancer.
Rui Cao, Fan Yang, +17 authors, Zhong-Yi Dong.
Theranostics, 2020 Oct 13; 10(24). PMID: 33042271    Free PMC article.
A Regulatory Science Initiative to Harmonize and Standardize Digital Pathology and Machine Learning Processes to Speed up Clinical Innovation to Patients.
Hetal Desai Marble, Richard Huang, +14 authors, Jochen K Lennerz.
J Pathol Inform, 2020 Oct 13; 11. PMID: 33042601    Free PMC article.
TissueWand, a Rapid Histopathology Annotation Tool.
Martin Lindvall, Alexander Sanner, +4 authors, Jonas Löwgren.
J Pathol Inform, 2020 Oct 13; 11. PMID: 33042606    Free PMC article.
Automatic Grading of Stroke Symptoms for Rapid Assessment Using Optimized Machine Learning and 4-Limb Kinematics: Clinical Validation Study.
Eunjeong Park, Kijeong Lee, Taehwa Han, Hyo Suk Nam.
J Med Internet Res, 2020 Sep 17; 22(9). PMID: 32936079    Free PMC article.
Accurate segmentation of prostate cancer histomorphometric features using a weakly supervised convolutional neural network.
John D Bukowy, Halle Foss, +15 authors, Peter S LaViolette.
J Med Imaging (Bellingham), 2020 Oct 17; 7(5). PMID: 33062803    Free PMC article.
Development of a prognostic model for mortality in COVID-19 infection using machine learning.
Adam L Booth, Elizabeth Abels, Peter McCaffrey.
Mod Pathol, 2020 Oct 18; 34(3). PMID: 33067522    Free PMC article.
A critical evaluation of visual proportion of Gleason 4 and maximum cancer core length quantified by histopathologists.
Lina Maria Carmona Echeverria, Aiman Haider, +29 authors, Hayley C Whitaker.
Sci Rep, 2020 Oct 16; 10(1). PMID: 33057024    Free PMC article.
SHIFT: speedy histological-to-immunofluorescent translation of a tumor signature enabled by deep learning.
Erik A Burlingame, Mary McDonnell, +7 authors, Young Hwan Chang.
Sci Rep, 2020 Oct 17; 10(1). PMID: 33060677    Free PMC article.
Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning.
Amelie Echle, Heike Irmgard Grabsch, +20 authors, Jakob Nikolas Kather.
Gastroenterology, 2020 Jun 21; 159(4). PMID: 32562722    Free PMC article.
Fine-Grained Breast Cancer Classification With Bilinear Convolutional Neural Networks (BCNNs).
Weihuang Liu, Mario Juhas, Yang Zhang.
Front Genet, 2020 Oct 27; 11. PMID: 33101377    Free PMC article.
Interpretable multimodal deep learning for real-time pan-tissue pan-disease pathology search on social media.
Andrew J Schaumberg, Wendy C Juarez-Nicanor, +27 authors, Thomas J Fuchs.
Mod Pathol, 2020 May 30; 33(11). PMID: 32467650    Free PMC article.
Using deep learning to predict anti-PD-1 response in melanoma and lung cancer patients from histopathology images.
Jing Hu, Chuanliang Cui, +4 authors, Yan Kong.
Transl Oncol, 2020 Nov 01; 14(1). PMID: 33129113    Free PMC article.
Review.
Spatial transcriptomics inferred from pathology whole-slide images links tumor heterogeneity to survival in breast and lung cancer.
Alona Levy-Jurgenson, Xavier Tekpli, Vessela N Kristensen, Zohar Yakhini.
Sci Rep, 2020 Nov 04; 10(1). PMID: 33139755    Free PMC article.
Attitudes Toward Artificial Intelligence Within Dermatopathology: An International Online Survey.
Sam Polesie, Phillip H McKee, +4 authors, John Paoli.
Front Med (Lausanne), 2020 Nov 17; 7. PMID: 33195357    Free PMC article.
Effective Immunohistochemistry Pathology Microscopy Image Generation Using CycleGAN.
Zidui Xu, Xi Li, +3 authors, Yupeng Chen.
Front Mol Biosci, 2020 Nov 17; 7. PMID: 33195418    Free PMC article.
Optimization of deep learning methods for visualization of tumor heterogeneity and brain tumor grading through digital pathology.
An Hoai Truong, Viktoriia Sharmanska, Clara Limbӓck-Stanic, Matthew Grech-Sollars.
Neurooncol Adv, 2020 Nov 17; 2(1). PMID: 33196039    Free PMC article.
Hidden Stratification Causes Clinically Meaningful Failures in Machine Learning for Medical Imaging.
Luke Oakden-Rayner, Jared Dunnmon, Gustavo Carneiro, Christopher Ré.
Proc ACM Conf Health Inference Learn (2020), 2020 Nov 17; 2020. PMID: 33196064    Free PMC article.
Automatic discovery of clinically interpretable imaging biomarkers for Mycobacterium tuberculosis supersusceptibility using deep learning.
Thomas E Tavolara, M Khalid Khan Niazi, +4 authors, Metin N Gurcan.
EBioMedicine, 2020 Nov 10; 62. PMID: 33166789    Free PMC article.
A narrative review of digital pathology and artificial intelligence: focusing on lung cancer.
Taro Sakamoto, Tomoi Furukawa, +8 authors, Junya Fukuoka.
Transl Lung Cancer Res, 2020 Nov 20; 9(5). PMID: 33209648    Free PMC article.
Review.
Automated Smart Home Assessment to Support Pain Management: Multiple Methods Analysis.
Roschelle L Fritz, Marian Wilson, +2 authors, Diane J Cook.
J Med Internet Res, 2020 Oct 27; 22(11). PMID: 33105099    Free PMC article.
Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains.
Nikhil Naik, Ali Madani, +5 authors, Richard Socher.
Nat Commun, 2020 Nov 18; 11(1). PMID: 33199723    Free PMC article.
Digital Pathology: Advantages, Limitations and Emerging Perspectives.
Stephan W Jahn, Markus Plass, Farid Moinfar.
J Clin Med, 2020 Nov 22; 9(11). PMID: 33217963    Free PMC article.
Review.
Deep Learning for Whole-Slide Tissue Histopathology Classification: A Comparative Study in the Identification of Dysplastic and Non-Dysplastic Barrett's Esophagus.
Rasoul Sali, Nazanin Moradinasab, +5 authors, Donald E Brown.
J Pers Med, 2020 Sep 27; 10(4). PMID: 32977465    Free PMC article.
Weakly supervised instance learning for thyroid malignancy prediction from whole slide cytopathology images.
David Dov, Shahar Z Kovalsky, +5 authors, Lawrence Carin.
Med Image Anal, 2020 Oct 14; 67. PMID: 33049578    Free PMC article.
Deep neural network models for computational histopathology: A survey.
Chetan L Srinidhi, Ozan Ciga, Anne L Martel.
Med Image Anal, 2020 Oct 14; 67. PMID: 33049577    Free PMC article.
Review.
Joint Imaging Platform for Federated Clinical Data Analytics.
Jonas Scherer, Marco Nolden, +58 authors, Klaus Maier-Hein.
JCO Clin Cancer Inform, 2020 Nov 10; 4. PMID: 33166197    Free PMC article.
A deep learning diagnostic platform for diffuse large B-cell lymphoma with high accuracy across multiple hospitals.
Dongguang Li, Jacob R Bledsoe, +5 authors, Shaoguang Li.
Nat Commun, 2020 Nov 28; 11(1). PMID: 33244018    Free PMC article.
VISTA: VIsual Semantic Tissue Analysis for pancreatic disease quantification in murine cohorts.
Luke Ternes, Ge Huang, +5 authors, Young Hwan Chang.
Sci Rep, 2020 Dec 03; 10(1). PMID: 33262400    Free PMC article.
Deep learning-based cross-classifications reveal conserved spatial behaviors within tumor histological images.
Javad Noorbakhsh, Saman Farahmand, +6 authors, Jeffrey H Chuang.
Nat Commun, 2020 Dec 15; 11(1). PMID: 33311458    Free PMC article.
Effectiveness of transfer learning for enhancing tumor classification with a convolutional neural network on frozen sections.
Young-Gon Kim, Sungchul Kim, +6 authors, Namkug Kim.
Sci Rep, 2020 Dec 16; 10(1). PMID: 33318495    Free PMC article.
Diagnosing 12 prostate needle cores within an hour of biopsy via open-top light-sheet microscopy.
Weisi Xie, Adam K Glaser, +4 authors, Lawrence D True.
J Biomed Opt, 2020 Dec 17; 25(12). PMID: 33325186    Free PMC article.
Deep Learning Predicts Underlying Features on Pathology Images with Therapeutic Relevance for Breast and Gastric Cancer.
Renan Valieris, Lucas Amaro, +6 authors, Israel Tojal da Silva.
Cancers (Basel), 2020 Dec 16; 12(12). PMID: 33316873    Free PMC article.
Deep learning-enabled medical computer vision.
Andre Esteva, Katherine Chou, +7 authors, Richard Socher.
NPJ Digit Med, 2021 Jan 10; 4(1). PMID: 33420381    Free PMC article.
Review.
Using Machine Learning Algorithms to Predict Immunotherapy Response in Patients with Advanced Melanoma.
Paul Johannet, Nicolas Coudray, +13 authors, Iman Osman.
Clin Cancer Res, 2020 Nov 20; 27(1). PMID: 33208341    Free PMC article.
Artificial intelligence and computational pathology.
Miao Cui, David Y Zhang.
Lab Invest, 2021 Jan 18; 101(4). PMID: 33454724    Free PMC article.
Review.
From Scope to Screen: The Evolution of Histology Education.
Jamie A Chapman, Lisa M J Lee, Nathan T Swailes.
Adv Exp Med Biol, 2020 Nov 20; 1260. PMID: 33211308
An interpretable classifier for high-resolution breast cancer screening images utilizing weakly supervised localization.
Yiqiu Shen, Nan Wu, +8 authors, Krzysztof J Geras.
Med Image Anal, 2021 Jan 01; 68. PMID: 33383334    Free PMC article.
Prediction of early recurrence of hepatocellular carcinoma after resection using digital pathology images assessed by machine learning.
Akira Saito, Hidenori Toyoda, +12 authors, Masahiko Kuroda.
Mod Pathol, 2020 Sep 20; 34(2). PMID: 32948835    Free PMC article.
Designing deep learning studies in cancer diagnostics.
Andreas Kleppe, Ole-Johan Skrede, +3 authors, Håvard E Danielsen.
Nat Rev Cancer, 2021 Jan 31; 21(3). PMID: 33514930
Review.
Artificial intelligence neuropathologist for glioma classification using deep learning on hematoxylin and eosin stained slide images and molecular markers.
Lei Jin, Feng Shi, +10 authors, Jinsong Wu.
Neuro Oncol, 2020 Jul 15; 23(1). PMID: 32663285    Free PMC article.
Aggregation of cohorts for histopathological diagnosis with deep morphological analysis.
Jeonghyuk Park, Yul Ri Chung, +5 authors, Kyu-Hwan Jung.
Sci Rep, 2021 Feb 05; 11(1). PMID: 33536550    Free PMC article.
SuperHistopath: A Deep Learning Pipeline for Mapping Tumor Heterogeneity on Low-Resolution Whole-Slide Digital Histopathology Images.
Konstantinos Zormpas-Petridis, Rosa Noguera, +3 authors, Yinyin Yuan.
Front Oncol, 2021 Feb 09; 10. PMID: 33552964    Free PMC article.
Automatic ganglion cell detection for improving the efficiency and accuracy of hirschprung disease diagnosis.
Ariel Greenberg, Asaf Aizic, +3 authors, Dov Hershkovitz.
Sci Rep, 2021 Feb 10; 11(1). PMID: 33558593    Free PMC article.
Semantic segmentation of reflectance confocal microscopy mosaics of pigmented lesions using weak labels.
Marissa D'Alonzo, Alican Bozkurt, +5 authors, Jennifer G Dy.
Sci Rep, 2021 Feb 13; 11(1). PMID: 33574486    Free PMC article.
Deep learning in cancer pathology: a new generation of clinical biomarkers.
Amelie Echle, Niklas Timon Rindtorff, +3 authors, Jakob Nikolas Kather.
Br J Cancer, 2020 Nov 19; 124(4). PMID: 33204028    Free PMC article.
Review.
Segmentation of cellular patterns in confocal images of melanocytic lesions in vivo via a multiscale encoder-decoder network (MED-Net).
Kivanc Kose, Alican Bozkurt, +6 authors, Milind Rajadhyaksha.
Med Image Anal, 2020 Nov 04; 67. PMID: 33142135    Free PMC article.
Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy.
Dmitrii Bychkov, Nina Linder, +10 authors, Johan Lundin.
Sci Rep, 2021 Feb 19; 11(1). PMID: 33597560    Free PMC article.
Contemporary application of artificial intelligence in prostate cancer: an i-TRUE study.
B M Zeeshan Hameed, Milap Shah, +5 authors, Bhavan Prasad Rai.
Ther Adv Urol, 2021 Feb 27; 13. PMID: 33633799    Free PMC article.
Review.
Perineural Invasion is a Better Prognostic Indicator than Lymphovascular Invasion and a Potential Adjuvant Therapy Indicator for pN0M0 Esophageal Squamous Cell Carcinoma.
Yuan-Ning Guo, Dong-Ping Tian, +12 authors, Min Su.
Ann Surg Oncol, 2020 Jun 11; 27(11). PMID: 32519146
Performance Evaluation of Deep Learning-Based Prostate Cancer Screening Methods in Histopathological Images: Measuring the Impact of the Model's Complexity on Its Processing Speed.
Lourdes Duran-Lopez, Juan P Dominguez-Morales, +4 authors, Alejandro Linares-Barranco.
Sensors (Basel), 2021 Feb 11; 21(4). PMID: 33562753    Free PMC article.
Computer Vision in the Operating Room: Opportunities and Caveats.
Lauren R Kennedy-Metz, Pietro Mascagni, +5 authors, Marco A Zenati.
IEEE Trans Med Robot Bionics, 2021 Mar 02; 3(1). PMID: 33644703    Free PMC article.
Artificial intelligence assistance significantly improves Gleason grading of prostate biopsies by pathologists.
Wouter Bulten, Maschenka Balkenhol, +20 authors, Geert Litjens.
Mod Pathol, 2020 Aug 08; 34(3). PMID: 32759979    Free PMC article.
An annotation-free whole-slide training approach to pathological classification of lung cancer types using deep learning.
Chi-Long Chen, Chi-Chung Chen, +6 authors, Cheng-Yu Chen.
Nat Commun, 2021 Feb 21; 12(1). PMID: 33608558    Free PMC article.
GestAltNet: aggregation and attention to improve deep learning of gestational age from placental whole-slide images.
Pooya Mobadersany, Lee A D Cooper, Jeffery A Goldstein.
Lab Invest, 2021 Mar 07; 101(7). PMID: 33674784    Free PMC article.
Artificial Intelligence and Machine Learning in Prostate Cancer Patient Management-Current Trends and Future Perspectives.
Octavian Sabin Tătaru, Mihai Dorin Vartolomei, +12 authors, Matteo Ferro.
Diagnostics (Basel), 2021 Mar 07; 11(2). PMID: 33672608    Free PMC article.
Review.
Development and Validation of a Personalized Survival Prediction Model for Uterine Adenosarcoma: A Population-Based Deep Learning Study.
Wenjie Qu, Qingqing Liu, +5 authors, Baoxia Cui.
Front Oncol, 2021 Mar 09; 10. PMID: 33680946    Free PMC article.
Human-interpretable image features derived from densely mapped cancer pathology slides predict diverse molecular phenotypes.
James A Diao, Jason K Wang, +19 authors, Amaro Taylor-Weiner.
Nat Commun, 2021 Mar 14; 12(1). PMID: 33712588    Free PMC article.
Harnessing non-destructive 3D pathology.
Jonathan T C Liu, Adam K Glaser, +4 authors, Anant Madabhushi.
Nat Biomed Eng, 2021 Feb 17; 5(3). PMID: 33589781    Free PMC article.
Review.
Deep Multi-Magnification Networks for multi-class breast cancer image segmentation.
David Joon Ho, Dig V K Yarlagadda, +6 authors, Thomas J Fuchs.
Comput Med Imaging Graph, 2021 Jan 24; 88. PMID: 33485058    Free PMC article.
A multi-resolution model for histopathology image classification and localization with multiple instance learning.
Jiayun Li, Wenyuan Li, +4 authors, Corey W Arnold.
Comput Biol Med, 2021 Feb 19; 131. PMID: 33601084    Free PMC article.
Accurate diagnosis of colorectal cancer based on histopathology images using artificial intelligence.
K S Wang, G Yu, +51 authors, H W Deng.
BMC Med, 2021 Mar 24; 19(1). PMID: 33752648    Free PMC article.
Pan-cancer image-based detection of clinically actionable genetic alterations.
Jakob Nikolas Kather, Lara R Heij, +25 authors, Tom Luedde.
Nat Cancer, 2021 Mar 26; 1(8). PMID: 33763651    Free PMC article.
Radiomic and radiogenomic modeling for radiotherapy: strategies, pitfalls, and challenges.
James T T Coates, Giacomo Pirovano, Issam El Naqa.
J Med Imaging (Bellingham), 2021 Mar 27; 8(3). PMID: 33768134    Free PMC article.
Review.
Predicting gastric cancer outcome from resected lymph node histopathology images using deep learning.
Xiaodong Wang, Ying Chen, +15 authors, Guanzhen Yu.
Nat Commun, 2021 Mar 14; 12(1). PMID: 33712598    Free PMC article.
Deep learning-based six-type classifier for lung cancer and mimics from histopathological whole slide images: a retrospective study.
Huan Yang, Lili Chen, +9 authors, Weizhong Li.
BMC Med, 2021 Mar 30; 19(1). PMID: 33775248    Free PMC article.
Decoding and Systematization of Medical Imaging Features of Multiple Human Malignancies.
Lu Wang, Zhaoyu Liu, +8 authors, Jiangdian Song.
Radiol Imaging Cancer, 2021 Mar 30; 2(5). PMID: 33778732    Free PMC article.
Development and evaluation of a deep neural network for histologic classification of renal cell carcinoma on biopsy and surgical resection slides.
Mengdan Zhu, Bing Ren, +3 authors, Saeed Hassanpour.
Sci Rep, 2021 Mar 31; 11(1). PMID: 33782535    Free PMC article.
Deep learning for computer-assisted diagnosis of hereditary diffuse gastric cancer.
Sean A Rasmussen, Thomas Arnason, Weei-Yuarn Huang.
J Pathol Transl Med, 2021 Jan 22; 55(2). PMID: 33472333    Free PMC article.
The Potential of Artificial Intelligence to Detect Lymphovascular Invasion in Testicular Cancer.
Abhisek Ghosh, Korsuk Sirinukunwattana, +8 authors, Clare Verrill.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33809521    Free PMC article.
Evolution of the liver biopsy and its future.
Dhanpat Jain, Richard Torres, +3 authors, Vasilis Vasiliou.
Transl Gastroenterol Hepatol, 2021 Apr 08; 6. PMID: 33824924    Free PMC article.
Review.
Artificial Intelligence in Cancer Research and Precision Medicine.
Bhavneet Bhinder, Coryandar Gilvary, Neel S Madhukar, Olivier Elemento.
Cancer Discov, 2021 Apr 04; 11(4). PMID: 33811123    Free PMC article.
Review.
Using artificial intelligence to assist radiologists in distinguishing COVID-19 from other pulmonary infections.
Yanhong Yang, Fleming Y M Lure, +4 authors, Lin Guo.
J Xray Sci Technol, 2020 Nov 10; 29(1). PMID: 33164982    Free PMC article.
A deep learning model for the classification of indeterminate lung carcinoma in biopsy whole slide images.
Fahdi Kanavati, Gouji Toyokawa, +6 authors, Masayuki Tsuneki.
Sci Rep, 2021 Apr 16; 11(1). PMID: 33854137    Free PMC article.
Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review.
Barbara Kenner, Suresh T Chari, +31 authors, Brian Wolpin.
Pancreas, 2021 Apr 10; 50(3). PMID: 33835956    Free PMC article.
Computational Image Analysis Identifies Histopathological Image Features Associated With Somatic Mutations and Patient Survival in Gastric Adenocarcinoma.
Jun Cheng, Yuting Liu, +7 authors, Jie Zhang.
Front Oncol, 2021 Apr 20; 11. PMID: 33869007    Free PMC article.
A deep learning model to detect pancreatic ductal adenocarcinoma on endoscopic ultrasound-guided fine-needle biopsy.
Yoshiki Naito, Masayuki Tsuneki, +25 authors, Hirohisa Yano.
Sci Rep, 2021 Apr 21; 11(1). PMID: 33875703    Free PMC article.
Real-time intraoperative glioma diagnosis using fluorescence imaging and deep convolutional neural networks.
Biluo Shen, Zhe Zhang, +5 authors, Jie Tian.
Eur J Nucl Med Mol Imaging, 2021 Apr 28; 48(11). PMID: 33904984    Free PMC article.
Overcoming the limitations of patch-based learning to detect cancer in whole slide images.
Ozan Ciga, Tony Xu, +3 authors, Anne L Martel.
Sci Rep, 2021 Apr 28; 11(1). PMID: 33903725    Free PMC article.
ImmunoAIzer: A Deep Learning-Based Computational Framework to Characterize Cell Distribution and Gene Mutation in Tumor Microenvironment.
Chang Bian, Yu Wang, +5 authors, Jie Tian.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33916145    Free PMC article.
Role of AI and Histopathological Images in Detecting Prostate Cancer: A Survey.
Sarah M Ayyad, Mohamed Shehata, +7 authors, Ayman El-Baz.
Sensors (Basel), 2021 May 01; 21(8). PMID: 33917035    Free PMC article.
Review.
Artificial Intelligence & Tissue Biomarkers: Advantages, Risks and Perspectives for Pathology.
Cesare Lancellotti, Pierandrea Cancian, +4 authors, Luca Di Tommaso.
Cells, 2021 May 01; 10(4). PMID: 33918173    Free PMC article.
Review.
Deep learning-based predictive identification of neural stem cell differentiation.
Yanjing Zhu, Ruiqi Huang, +3 authors, Rongrong Zhu.
Nat Commun, 2021 May 12; 12(1). PMID: 33972525    Free PMC article.
Combining weakly and strongly supervised learning improves strong supervision in Gleason pattern classification.
Sebastian Otálora, Niccolò Marini, Henning Müller, Manfredo Atzori.
BMC Med Imaging, 2021 May 10; 21(1). PMID: 33964886    Free PMC article.
Deep learning in histopathology: the path to the clinic.
Jeroen van der Laak, Geert Litjens, Francesco Ciompi.
Nat Med, 2021 May 16; 27(5). PMID: 33990804
Review.
Evaluation of the Use of Single- and Multi-Magnification Convolutional Neural Networks for the Determination and Quantitation of Lesions in Nonclinical Pathology Studies.
Jogile Kuklyte, Jenny Fitzgerald, +14 authors, Donal O'Shea.
Toxicol Pathol, 2021 Feb 24; 49(4). PMID: 33618634    Free PMC article.
Machine learning of EEG spectra classifies unconsciousness during GABAergic anesthesia.
John H Abel, Marcus A Badgeley, +8 authors, Emery N Brown.
PLoS One, 2021 May 07; 16(5). PMID: 33956800    Free PMC article.
Deep learning-based molecular morphometrics for kidney biopsies.
Marina Zimmermann, Martin Klaus, +16 authors, Victor G Puelles.
JCI Insight, 2021 Mar 12; 6(7). PMID: 33705360    Free PMC article.
Selection of Representative Histologic Slides in Interobserver Reproducibility Studies: Insights from Expert Review for Ovarian Carcinoma Subtype Classification.
Marios A Gavrielides, Brigitte M Ronnett, +2 authors, Jeffrey D Seidman.
J Pathol Inform, 2021 May 21; 12. PMID: 34012719    Free PMC article.
Deep learning predicts gene expression as an intermediate data modality to identify susceptibility patterns in Mycobacterium tuberculosis infected Diversity Outbred mice.
Thomas E Tavolara, M K K Niazi, +3 authors, Metin N Gurcan.
EBioMedicine, 2021 May 18; 67. PMID: 34000621    Free PMC article.
Automated gleason grading on prostate biopsy slides by statistical representations of homology profile.
Chaoyang Yan, Kazuaki Nakane, +6 authors, Jun Xu.
Comput Methods Programs Biomed, 2020 May 30; 194. PMID: 32470903    Free PMC article.
Rise of Clinical Studies in the Field of Machine Learning: A Review of Data Registered in ClinicalTrials.gov.
Claus Zippel, Sabine Bohnet-Joschko.
Int J Environ Res Public Health, 2021 Jun 03; 18(10). PMID: 34064827    Free PMC article.
Review.
Deep Learning for the Classification of Non-Hodgkin Lymphoma on Histopathological Images.
Georg Steinbuss, Mark Kriegsmann, +5 authors, Katharina Kriegsmann.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34067726    Free PMC article.
Classification of Diffuse Glioma Subtype from Clinical-Grade Pathological Images Using Deep Transfer Learning.
Sanghyuk Im, Jonghwan Hyeon, +4 authors, Tae-Jung Kim.
Sensors (Basel), 2021 Jun 03; 21(10). PMID: 34067934    Free PMC article.
Challenges and opportunities of digital health in a post-COVID19 world.
Amirreza Manteghinejad, Shaghayegh Haghjooy Javanmard.
J Res Med Sci, 2021 Jun 05; 26. PMID: 34084190    Free PMC article.
Review.
Dual attention multiple instance learning with unsupervised complementary loss for COVID-19 screening.
Philip Chikontwe, Miguel Luna, +3 authors, Sang Hyun Park.
Med Image Anal, 2021 Jun 09; 72. PMID: 34102477    Free PMC article.
Hybrid AI-assistive diagnostic model permits rapid TBS classification of cervical liquid-based thin-layer cell smears.
Xiaohui Zhu, Xiaoming Li, +31 authors, Yanqing Ding.
Nat Commun, 2021 Jun 12; 12(1). PMID: 34112790    Free PMC article.
Ensemble machine learning approach for screening of coronary heart disease based on echocardiography and risk factors.
Jingyi Zhang, Huolan Zhu, +5 authors, Fang Wang.
BMC Med Inform Decis Mak, 2021 Jun 13; 21(1). PMID: 34116660    Free PMC article.
Yet Another Automated Gleason Grading System (YAAGGS) by weakly supervised deep learning.
Yechan Mun, Inyoung Paik, +2 authors, Hyeyoon Chang.
NPJ Digit Med, 2021 Jun 16; 4(1). PMID: 34127777    Free PMC article.
Requirements for implementation of artificial intelligence in the practice of gastrointestinal pathology.
Hiroshi Yoshida, Tomoharu Kiyuna.
World J Gastroenterol, 2021 Jun 18; 27(21). PMID: 34135556    Free PMC article.
Review.
Development and Validation of an Interpretable Artificial Intelligence Model to Predict 10-Year Prostate Cancer Mortality.
Jean-Emmanuel Bibault, Steven Hancock, +4 authors, Lei Xing.
Cancers (Basel), 2021 Jul 03; 13(12). PMID: 34205398    Free PMC article.
Independent real-world application of a clinical-grade automated prostate cancer detection system.
Leonard M da Silva, Emilio M Pereira, +18 authors, Jorge S Reis-Filho.
J Pathol, 2021 Apr 28; 254(2). PMID: 33904171    Free PMC article.
A Comprehensive Study of Data Augmentation Strategies for Prostate Cancer Detection in Diffusion-Weighted MRI Using Convolutional Neural Networks.
Ruqian Hao, Khashayar Namdar, +2 authors, Farzad Khalvati.
J Digit Imaging, 2021 Jul 14; 34(4). PMID: 34254200    Free PMC article.
CAD systems for colorectal cancer from WSI are still not ready for clinical acceptance.
Sara P Oliveira, Pedro C Neto, +7 authors, Jaime S Cardoso.
Sci Rep, 2021 Jul 15; 11(1). PMID: 34257363    Free PMC article.
Artificial Intelligence in Pathology.
Sebastian Försch, Frederick Klauschen, Peter Hufnagl, Wilfried Roth.
Dtsch Arztebl Int, 2021 May 25; 118(12). PMID: 34024323    Free PMC article.
Review.
Deep Learning Models for Gastric Signet Ring Cell Carcinoma Classification in Whole Slide Images.
Fahdi Kanavati, Shin Ichihara, +3 authors, Masayuki Tsuneki.
Technol Cancer Res Treat, 2021 Jul 01; 20. PMID: 34191660    Free PMC article.
Integrated imaging and molecular analysis to decipher tumor microenvironment in the era of immunotherapy.
Jia Wu, Aaron T Mayer, Ruijiang Li.
Semin Cancer Biol, 2020 Dec 09;. PMID: 33290844    Free PMC article.
An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy.
Sudhir Perincheri, Angelique Wolf Levi, +7 authors, John Sinard.
Mod Pathol, 2021 Mar 31; 34(8). PMID: 33782551    Free PMC article.
Integrated digital pathology at scale: A solution for clinical diagnostics and cancer research at a large academic medical center.
Peter J Schüffler, Luke Geneslaw, +29 authors, Thomas J Fuchs.
J Am Med Inform Assoc, 2021 Jul 15; 28(9). PMID: 34260720    Free PMC article.
Automated tumor proportion score analysis for PD-L1 (22C3) expression in lung squamous cell carcinoma.
Jingxin Liu, Qiang Zheng, +14 authors, Yuan Li.
Sci Rep, 2021 Aug 07; 11(1). PMID: 34354151    Free PMC article.
A deep learning-based radiomic nomogram for prognosis and treatment decision in advanced nasopharyngeal carcinoma: A multicentre study.
Lianzhen Zhong, Di Dong, +15 authors, Jie Tian.
EBioMedicine, 2021 Aug 15; 70. PMID: 34391094    Free PMC article.
Interobserver variability between experienced and inexperienced observers in the histopathological analysis of Wilms tumors: a pilot study for future algorithmic approach.
Jikke J Rutgers, Tessa Bánki, +7 authors, Ronald R de Krijger.
Diagn Pathol, 2021 Aug 23; 16(1). PMID: 34419100    Free PMC article.
Artificial intelligence for the next generation of precision oncology.
Pedro J Ballester, Javier Carmona.
NPJ Precis Oncol, 2021 Aug 20; 5(1). PMID: 34408248    Free PMC article.
Detection of HER2 from Haematoxylin-Eosin Slides Through a Cascade of Deep Learning Classifiers via Multi-Instance Learning.
David La Barbera, António Polónia, +2 authors, Vincenzo Della Mea.
J Imaging, 2021 Aug 31; 6(9). PMID: 34460739    Free PMC article.
Development and evaluation of deep learning-based segmentation of histologic structures in the kidney cortex with multiple histologic stains.
Catherine P Jayapandian, Yijiang Chen, +12 authors, Nephrotic Syndrome Study Network (NEPTUNE).
Kidney Int, 2020 Aug 25; 99(1). PMID: 32835732    Free PMC article.
Best Practices for Spatial Profiling for Breast Cancer Research with the GeoMx® Digital Spatial Profiler.
Helga Bergholtz, Jodi M Carter, +30 authors, On Behalf Of The GeoMx Breast Cancer Consortium.
Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503266    Free PMC article.
Low-count whole-body PET with deep learning in a multicenter and externally validated study.
Akshay S Chaudhari, Erik Mittra, +8 authors, Hossein Jadvar.
NPJ Digit Med, 2021 Aug 25; 4(1). PMID: 34426629    Free PMC article.
Resolution-based distillation for efficient histology image classification.
Joseph DiPalma, Arief A Suriawinata, +2 authors, Saeed Hassanpour.
Artif Intell Med, 2021 Sep 18; 119. PMID: 34531005    Free PMC article.
Identification of nodal micrometastasis in colorectal cancer using deep learning on annotation-free whole-slide images.
Wen-Yu Chuang, Chi-Chung Chen, +7 authors, Chao-Yuan Yeh.
Mod Pathol, 2021 Jun 10; 34(10). PMID: 34103664    Free PMC article.
Predictive models of response to neoadjuvant chemotherapy in muscle-invasive bladder cancer using nuclear morphology and tissue architecture.
Haoyang Mi, Trinity J Bivalacqua, +4 authors, Alexander S Baras.
Cell Rep Med, 2021 Oct 09; 2(9). PMID: 34622225    Free PMC article.
Recent advances in blood-based and artificial intelligence-enhanced approaches for gastrointestinal cancer diagnosis.
Li-Shi Li, Xiang-Yu Guo, Kun Sun.
World J Gastroenterol, 2021 Oct 12; 27(34). PMID: 34629793    Free PMC article.
Review.
Harnessing multimodal data integration to advance precision oncology.
Kevin M Boehm, Pegah Khosravi, +2 authors, Sohrab P Shah.
Nat Rev Cancer, 2021 Oct 20;. PMID: 34663944
Review.
A deep learning model for gastric diffuse-type adenocarcinoma classification in whole slide images.
Fahdi Kanavati, Masayuki Tsuneki.
Sci Rep, 2021 Oct 16; 11(1). PMID: 34650155    Free PMC article.
Machine Learning of Bone Marrow Histopathology Identifies Genetic and Clinical Determinants in Patients with MDS.
Oscar E Brück, Susanna E Lallukka-Brück, +8 authors, Satu M Mustjoki.
Blood Cancer Discov, 2021 Oct 19; 2(3). PMID: 34661156    Free PMC article.
Robust whole slide image analysis for cervical cancer screening using deep learning.
Shenghua Cheng, Sibo Liu, +20 authors, Xiuli Liu.
Nat Commun, 2021 Sep 26; 12(1). PMID: 34561435    Free PMC article.
Deep-learning-assisted microscopy with ultraviolet surface excitation for rapid slide-free histological imaging.
Zhenghui Chen, Wentao Yu, Ivy H M Wong, Terence T W Wong.
Biomed Opt Express, 2021 Oct 26; 12(9). PMID: 34692225    Free PMC article.
Qualitative Histopathological Classification of Primary Bone Tumors Using Deep Learning: A Pilot Study.
Yuzhang Tao, Xiao Huang, +16 authors, Jian Zhang.
Front Oncol, 2021 Oct 26; 11. PMID: 34692509    Free PMC article.
Second-Generation Digital Health Platforms: Placing the Patient at the Center and Focusing on Clinical Outcomes.
Yaron Ilan.
Front Digit Health, 2021 Oct 30; 2. PMID: 34713042    Free PMC article.
Predicting Axillary Lymph Node Metastasis in Early Breast Cancer Using Deep Learning on Primary Tumor Biopsy Slides.
Feng Xu, Chuang Zhu, +7 authors, Mulan Jin.
Front Oncol, 2021 Nov 02; 11. PMID: 34722313    Free PMC article.