Review
. 2019 Aug; 10:1719.
doi: 10.3389/fimmu.2019.01719.

T Cell Dysfunction in Cancer Immunity and Immunotherapy

Anliang Xia 1 Yan Zhang 2 Jiang Xu 3 Tailang Yin 4 Xiao-Jie Lu 1 
Affiliations
  • PMID: 31379886
  •     212 References
  •     89 citations

Abstract

In cancer, T cells become dysfunctional owing to persistent antigen exposure. Dysfunctional T cells are characterized by reduced proliferative capacity, decreased effector function, and overexpression of multiple inhibitory receptors. Due to the presence of various inhibitory signals in the complex tumor microenvironment, tumor-specific T cells have distinct dysfunction states. Therapeutic reactivation of tumor-specific T cells has yielded good results in cancer patients. Here, we review the hallmarks of T cell dysfunction in cancer. Also, we discuss the relationship between T cell dysfunction and cancer immunotherapy.

Keywords: T cell dysfunction; cancer; immunity; immunotherapy; tumor microenvironment.

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Extracellular adenosine-mediated modulation of regulatory T cells.
Akio Ohta, Michail Sitkovsky.
Front Immunol, 2014 Jul 30; 5. PMID: 25071765    Free PMC article.
Highly Cited.
Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.
Pia Kvistborg, Daisy Philips, +13 authors, Ton N Schumacher.
Sci Transl Med, 2014 Sep 19; 6(254). PMID: 25232180
Highly Cited.
The aryl hydrocarbon receptor meets immunology: friend or foe? A little of both.
Walker Julliard, John H Fechner, Joshua D Mezrich.
Front Immunol, 2014 Oct 18; 5. PMID: 25324842    Free PMC article.
Review.
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Yu-Hwa Huang, Chen Zhu, +21 authors, Richard S Blumberg.
Nature, 2014 Nov 05; 517(7534). PMID: 25363763    Free PMC article.
Highly Cited.
Combination of 4-1BB agonist and PD-1 antagonist promotes antitumor effector/memory CD8 T cells in a poorly immunogenic tumor model.
Shihao Chen, Li-Fen Lee, +12 authors, John C Lin.
Cancer Immunol Res, 2014 Nov 13; 3(2). PMID: 25387892
Highly Cited.
The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection.
Matthew M Staron, Simon M Gray, +6 authors, Susan M Kaech.
Immunity, 2014 Dec 04; 41(5). PMID: 25464856    Free PMC article.
Highly Cited.
The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function.
Robert J Johnston, Laetitia Comps-Agrar, +9 authors, Jane L Grogan.
Cancer Cell, 2014 Dec 04; 26(6). PMID: 25465800
Highly Cited.
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma.
Stephen M Ansell, Alexander M Lesokhin, +16 authors, Philippe Armand.
N Engl J Med, 2014 Dec 09; 372(4). PMID: 25482239    Free PMC article.
Highly Cited.
VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors.
Thibault Voron, Orianne Colussi, +15 authors, Magali Terme.
J Exp Med, 2015 Jan 21; 212(2). PMID: 25601652    Free PMC article.
Highly Cited.
Type I interferons in infectious disease.
Finlay McNab, Katrin Mayer-Barber, +2 authors, Anne O'Garra.
Nat Rev Immunol, 2015 Jan 24; 15(2). PMID: 25614319    Free PMC article.
Highly Cited. Review.
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
Gustavo J Martinez, Renata M Pereira, +13 authors, Anjana Rao.
Immunity, 2015 Feb 15; 42(2). PMID: 25680272    Free PMC article.
Highly Cited.
Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment.
Kazuhiro Tanaka, Takashi Sasayama, +14 authors, Eiji Kohmura.
J Clin Invest, 2015 Mar 24; 125(4). PMID: 25798620    Free PMC article.
Highly Cited.
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation.
Nikolaos Patsoukis, Kankana Bardhan, +9 authors, Vassiliki A Boussiotis.
Nat Commun, 2015 Mar 27; 6. PMID: 25809635    Free PMC article.
Highly Cited.
The future of immune checkpoint therapy.
Padmanee Sharma, James P Allison.
Science, 2015 Apr 04; 348(6230). PMID: 25838373
Highly Cited. Review.
TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients.
Joe-Marc Chauvin, Ornella Pagliano, +8 authors, Hassane M Zarour.
J Clin Invest, 2015 Apr 14; 125(5). PMID: 25866972    Free PMC article.
Highly Cited.
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.
James Larkin, Vanna Chiarion-Sileni, +28 authors, Jedd D Wolchok.
N Engl J Med, 2015 Jun 02; 373(1). PMID: 26027431    Free PMC article.
Highly Cited.
The paradoxical role of IL-10 in immunity and cancer.
Mark H Mannino, Ziwen Zhu, +3 authors, Yujiang Fang.
Cancer Lett, 2015 Jul 19; 367(2). PMID: 26188281
Highly Cited. Review.
Molecular and cellular insights into T cell exhaustion.
E John Wherry, Makoto Kurachi.
Nat Rev Immunol, 2015 Jul 25; 15(8). PMID: 26205583    Free PMC article.
Highly Cited. Review.
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression.
Chih-Hao Chang, Jing Qiu, +11 authors, Erika L Pearce.
Cell, 2015 Sep 01; 162(6). PMID: 26321679    Free PMC article.
Highly Cited.
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.
Ping-Chih Ho, Jessica Dauz Bihuniak, +15 authors, Susan M Kaech.
Cell, 2015 Sep 01; 162(6). PMID: 26321681    Free PMC article.
Highly Cited.
Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance.
Willy Hugo, Hubing Shi, +10 authors, Roger S Lo.
Cell, 2015 Sep 12; 162(6). PMID: 26359985    Free PMC article.
Highly Cited.
Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma.
Robert J Motzer, Bernard Escudier, +25 authors, CheckMate 025 Investigators.
N Engl J Med, 2015 Sep 26; 373(19). PMID: 26406148    Free PMC article.
Highly Cited.
TIGIT predominantly regulates the immune response via regulatory T cells.
Sema Kurtulus, Kaori Sakuishi, +6 authors, Ana C Anderson.
J Clin Invest, 2015 Sep 29; 125(11). PMID: 26413872    Free PMC article.
Highly Cited.
Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction.
Ende Zhao, Tomasz Maj, +22 authors, Weiping Zou.
Nat Immunol, 2015 Nov 03; 17(1). PMID: 26523864    Free PMC article.
Highly Cited.
Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy.
Shari Pilon-Thomas, Krithika N Kodumudi, +8 authors, Robert J Gillies.
Cancer Res, 2016 Jan 01; 76(6). PMID: 26719539    Free PMC article.
Highly Cited.
IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance.
David H Munn, Andrew L Mellor.
Trends Immunol, 2016 Feb 04; 37(3). PMID: 26839260    Free PMC article.
Highly Cited. Review.
Interleukin-35 Limits Anti-Tumor Immunity.
Meghan E Turnis, Deepali V Sawant, +7 authors, Dario A A Vignali.
Immunity, 2016 Feb 14; 44(2). PMID: 26872697    Free PMC article.
Highly Cited.
Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.
Shohei Koyama, Esra A Akbay, +23 authors, Peter S Hammerman.
Nat Commun, 2016 Feb 18; 7. PMID: 26883990    Free PMC article.
Highly Cited.
PD-1 expression conditions T cell avidity within an antigen-specific repertoire.
Sylvain Simon, Virginie Vignard, +4 authors, N Labarriere.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942093    Free PMC article.
Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial.
Louis Fehrenbacher, Alexander Spira, +16 authors, POPLAR Study Group.
Lancet, 2016 Mar 14; 387(10030). PMID: 26970723
Highly Cited.
PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma.
Paul T Nghiem, Shailender Bhatia, +28 authors, Martin A Cheever.
N Engl J Med, 2016 Apr 20; 374(26). PMID: 27093365    Free PMC article.
Highly Cited.
Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model.
Eloah Rabello Suarez, De Kuan Chang, +5 authors, Wayne A Marasco.
Oncotarget, 2016 May 05; 7(23). PMID: 27145284    Free PMC article.
Highly Cited.
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.
Jesse M Zaretsky, Angel Garcia-Diaz, +26 authors, Antoni Ribas.
N Engl J Med, 2016 Jul 20; 375(9). PMID: 27433843    Free PMC article.
Highly Cited.
Demethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion.
Eunseon Ahn, Ben Youngblood, +3 authors, Rafi Ahmed.
J Virol, 2016 Jul 29; 90(19). PMID: 27466420    Free PMC article.
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy.
Se Jin Im, Masao Hashimoto, +13 authors, Rafi Ahmed.
Nature, 2016 Aug 09; 537(7620). PMID: 27501248    Free PMC article.
Highly Cited.
Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis.
Andrea Schietinger, Mary Philip, +10 authors, Philip D Greenberg.
Immunity, 2016 Aug 16; 45(2). PMID: 27521269    Free PMC article.
Highly Cited.
The biology and function of fibroblasts in cancer.
Raghu Kalluri.
Nat Rev Cancer, 2016 Aug 24; 16(9). PMID: 27550820
Highly Cited. Review.
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade.
Kristen E Pauken, Morgan A Sammons, +16 authors, E John Wherry.
Science, 2016 Oct 30; 354(6316). PMID: 27789795    Free PMC article.
Highly Cited.
The epigenetic landscape of T cell exhaustion.
Debattama R Sen, James Kaminski, +16 authors, W Nicholas Haining.
Science, 2016 Oct 30; 354(6316). PMID: 27789799    Free PMC article.
Highly Cited.
CAR T Cell Therapy for Solid Tumors.
Kheng Newick, Shaun O'Brien, Edmund Moon, Steven M Albelda.
Annu Rev Med, 2016 Nov 20; 68. PMID: 27860544
Highly Cited. Review.
IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus.
S Drennan, A D'Avola, +11 authors, F Forconi.
Leukemia, 2016 Nov 29; 31(8). PMID: 27890932
Regulatory T cells in cancer immunotherapy.
Atsushi Tanaka, Shimon Sakaguchi.
Cell Res, 2016 Dec 21; 27(1). PMID: 27995907    Free PMC article.
Highly Cited. Review.
Tumor antigen-specific CD8+ T cells are negatively regulated by PD-1 and Tim-3 in human gastric cancer.
Xu Lu, Lin Yang, +8 authors, Jingwei Liu.
Cell Immunol, 2017 Jan 24; 313. PMID: 28110884
Shaping of Peripheral T Cell Responses by Lymphatic Endothelial Cells.
Marion Humbert, Stéphanie Hugues, Juan Dubrot.
Front Immunol, 2017 Jan 28; 7. PMID: 28127298    Free PMC article.
Review.
Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy.
Paul A Beavis, Melissa A Henderson, +15 authors, Phillip K Darcy.
J Clin Invest, 2017 Feb 07; 127(3). PMID: 28165340    Free PMC article.
Highly Cited.
Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer.
Gulidanna Shayan, Raghvendra Srivastava, +3 authors, Robert L Ferris.
Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197389    Free PMC article.
Highly Cited.
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.
Enfu Hui, Jeanne Cheung, +8 authors, Ronald D Vale.
Science, 2017 Mar 11; 355(6332). PMID: 28280247    Free PMC article.
Highly Cited.
Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.
Alice O Kamphorst, Andreas Wieland, +17 authors, Rafi Ahmed.
Science, 2017 Mar 11; 355(6332). PMID: 28280249    Free PMC article.
Highly Cited.
Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate.
Chun-Kai Huang, Po-Hao Chang, +6 authors, Wen-Hwa Lee.
Nat Commun, 2017 Mar 11; 8. PMID: 28281525    Free PMC article.
Exhaustion-associated regulatory regions in CD8+ tumor-infiltrating T cells.
Giuliana P Mognol, Roberto Spreafico, +6 authors, Sara Trifari.
Proc Natl Acad Sci U S A, 2017 Mar 12; 114(13). PMID: 28283662    Free PMC article.
Highly Cited.
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells.
Levi J Rupp, Kathrin Schumann, +4 authors, Alexander Marson.
Sci Rep, 2017 Apr 09; 7(1). PMID: 28389661    Free PMC article.
Highly Cited.
Advances of CD19-directed chimeric antigen receptor-modified T cells in refractory/relapsed acute lymphoblastic leukemia.
Guoqing Wei, Lijuan Ding, +2 authors, He Huang.
Exp Hematol Oncol, 2017 Apr 18; 6. PMID: 28413717    Free PMC article.
Highly Cited. Review.
Immunotherapy in hematologic malignancies: past, present, and future.
Annie Im, Steven Z Pavletic.
J Hematol Oncol, 2017 Apr 25; 10(1). PMID: 28434396    Free PMC article.
Review.
Combined Anti-VEGF and Anti-CTLA-4 Therapy Elicits Humoral Immunity to Galectin-1 Which Is Associated with Favorable Clinical Outcomes.
Xinqi Wu, Jingjing Li, +12 authors, F Stephen Hodi.
Cancer Immunol Res, 2017 May 06; 5(6). PMID: 28473314    Free PMC article.
Chromatin states define tumour-specific T cell dysfunction and reprogramming.
Mary Philip, Lauren Fairchild, +11 authors, Andrea Schietinger.
Nature, 2017 May 18; 545(7655). PMID: 28514453    Free PMC article.
Highly Cited.
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.
Dung T Le, Jennifer N Durham, +43 authors, Luis A Diaz.
Science, 2017 Jun 10; 357(6349). PMID: 28596308    Free PMC article.
Highly Cited.
CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells.
Yongping Zhang, Xingying Zhang, +7 authors, Haoyi Wang.
Front Med, 2017 Jun 19; 11(4). PMID: 28625015
Highly Cited.
Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia.
Liuluan Zhu, Yaxian Kong, +11 authors, Hong Zheng.
J Hematol Oncol, 2017 Jun 21; 10(1). PMID: 28629373    Free PMC article.
De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation.
Hazem E Ghoneim, Yiping Fan, +8 authors, Ben Youngblood.
Cell, 2017 Jun 27; 170(1). PMID: 28648661    Free PMC article.
Highly Cited.
From Krebs to clinic: glutamine metabolism to cancer therapy.
Brian J Altman, Zachary E Stine, Chi V Dang.
Nat Rev Cancer, 2017 Jul 14; 16(11). PMID: 28704361
Highly Cited.
Identification of essential genes for cancer immunotherapy.
Shashank J Patel, Neville E Sanjana, +21 authors, Nicholas P Restifo.
Nature, 2017 Aug 08; 548(7669). PMID: 28783722    Free PMC article.
Highly Cited.
Concurrent PD-1 Blockade Negates the Effects of OX40 Agonist Antibody in Combination Immunotherapy through Inducing T-cell Apoptosis.
Rajeev K Shrimali, Shamim Ahmad, +12 authors, Samir N Khleif.
Cancer Immunol Res, 2017 Aug 30; 5(9). PMID: 28848055
Highly Cited.
Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.
Ying Zhang, Raj Kurupati, +17 authors, Hildegund C J Ertl.
Cancer Cell, 2017 Sep 13; 32(3). PMID: 28898698    Free PMC article.
Highly Cited.
Culturing CTLs under Hypoxic Conditions Enhances Their Cytolysis and Improves Their Anti-tumor Function.
Yael Gropper, Tali Feferman, +3 authors, Guy Shakhar.
Cell Rep, 2017 Sep 14; 20(11). PMID: 28903036
Enhanced Cancer Immunotherapy by Chimeric Antigen Receptor-Modified T Cells Engineered to Secrete Checkpoint Inhibitors.
Si Li, Natnaree Siriwon, +9 authors, Pin Wang.
Clin Cancer Res, 2017 Sep 16; 23(22). PMID: 28912137
Highly Cited.
FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity.
Arnaud Delpoux, Chen-Yen Lai, Stephen M Hedrick, Andrew L Doedens.
Proc Natl Acad Sci U S A, 2017 Oct 05; 114(42). PMID: 28973925    Free PMC article.
The diverse functions of the PD1 inhibitory pathway.
Arlene H Sharpe, Kristen E Pauken.
Nat Rev Immunol, 2017 Oct 11; 18(3). PMID: 28990585
Highly Cited. Review.
IL10 Release upon PD-1 Blockade Sustains Immunosuppression in Ovarian Cancer.
Purushottam Lamichhane, Lavakumar Karyampudi, +8 authors, Keith L Knutson.
Cancer Res, 2017 Oct 11; 77(23). PMID: 28993412    Free PMC article.
Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity.
Houjun Xia, Wei Wang, +12 authors, Weiping Zou.
Sci Immunol, 2017 Nov 19; 2(17). PMID: 29150439    Free PMC article.
Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection.
Kevin Man, Sarah S Gabriel, +9 authors, Axel Kallies.
Immunity, 2017 Dec 17; 47(6). PMID: 29246443
Highly Cited.
Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution.
Mirjana Efremova, Dietmar Rieder, +8 authors, Zlatko Trajanoski.
Nat Commun, 2018 Jan 04; 9(1). PMID: 29296022    Free PMC article.
Highly Cited.
High response rate to PD-1 blockade in desmoplastic melanomas.
Zeynep Eroglu, Jesse M Zaretsky, +22 authors, Antoni Ribas.
Nature, 2018 Jan 11; 553(7688). PMID: 29320474    Free PMC article.
Highly Cited.
Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease.
Xianyi Meng, Bettina Grötsch, +7 authors, Aline Bozec.
Nat Commun, 2018 Jan 19; 9(1). PMID: 29343683    Free PMC article.
Highly Cited.
Myeloid-derived suppressor cells coming of age.
Filippo Veglia, Michela Perego, Dmitry Gabrilovich.
Nat Immunol, 2018 Jan 20; 19(2). PMID: 29348500    Free PMC article.
Highly Cited. Review.
Incorporation of Immune Checkpoint Blockade into Chimeric Antigen Receptor T Cells (CAR-Ts): Combination or Built-In CAR-T.
Dok Hyun Yoon, Mark J Osborn, Jakub Tolar, Chong Jai Kim.
Int J Mol Sci, 2018 Jan 25; 19(2). PMID: 29364163    Free PMC article.
Highly Cited. Review.
Activity of pembrolizumab in relapsed/refractory NK/T-cell lymphoma.
Xin Li, Yasong Cheng, +15 authors, Ken H Young.
J Hematol Oncol, 2018 Feb 02; 11(1). PMID: 29386072    Free PMC article.
Highly Cited.
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.
Sanjeev Mariathasan, Shannon J Turley, +39 authors, Thomas Powles.
Nature, 2018 Feb 15; 554(7693). PMID: 29443960    Free PMC article.
Highly Cited.
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.
Daniele V F Tauriello, Sergio Palomo-Ponce, +15 authors, Eduard Batlle.
Nature, 2018 Feb 15; 554(7693). PMID: 29443964
Highly Cited.
Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells.
Matthew A Lakins, Ehsan Ghorani, +2 authors, Jacqueline D Shields.
Nat Commun, 2018 Mar 07; 9(1). PMID: 29507342    Free PMC article.
Highly Cited.
Driving T-cell immunotherapy to solid tumors.
Ken Garber.
Nat Biotechnol, 2018 Mar 07; 36(3). PMID: 29509745
Next generation of immune checkpoint therapy in cancer: new developments and challenges.
Julian A Marin-Acevedo, Bhagirathbhai Dholaria, +3 authors, Yanyan Lou.
J Hematol Oncol, 2018 Mar 17; 11(1). PMID: 29544515    Free PMC article.
Highly Cited. Review.
Cancer immunotherapy using checkpoint blockade.
Antoni Ribas, Jedd D Wolchok.
Science, 2018 Mar 24; 359(6382). PMID: 29567705    Free PMC article.
Highly Cited. Review.
Potent anti-leukemia activities of humanized CD19-targeted Chimeric antigen receptor T (CAR-T) cells in patients with relapsed/refractory acute lymphoblastic leukemia.
Jiang Cao, Gang Wang, +15 authors, Kailin Xu.
Am J Hematol, 2018 Apr 11; 93(7). PMID: 29633386
miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy.
Qian Huang, Jiajia Xia, +12 authors, Yong Li.
J Hematol Oncol, 2018 Apr 25; 11(1). PMID: 29685162    Free PMC article.
Nucleofection with Plasmid DNA for CRISPR/Cas9-Mediated Inactivation of Programmed Cell Death Protein 1 in CD133-Specific CAR T Cells.
Bian Hu, Yan Zou, +5 authors, Xuekai Zhu.
Hum Gene Ther, 2018 May 01; 30(4). PMID: 29706119
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia.
Joseph A Fraietta, Simon F Lacey, +34 authors, J Joseph Melenhorst.
Nat Med, 2018 May 02; 24(5). PMID: 29713085    Free PMC article.
Highly Cited.
Anti-CTLA-4 based therapy elicits humoral immunity to galectin-3 in patients with metastatic melanoma.
Xinqi Wu, Anita Giobbie-Hurder, +6 authors, F Stephen Hodi.
Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900046    Free PMC article.
Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo.
Sarwish Rafiq, Oladapo O Yeku, +14 authors, Renier J Brentjens.
Nat Biotechnol, 2018 Aug 14; 36(9). PMID: 30102295    Free PMC article.
Highly Cited.
Tim-3 expression and its role in hepatocellular carcinoma.
Feifei Liu, Yanning Liu, Zhi Chen.
J Hematol Oncol, 2018 Oct 13; 11(1). PMID: 30309387    Free PMC article.
Review.
Programmed cell death protein 1 activation preferentially inhibits CD28.CAR-T cells.
Sergey N Zolov, Skyler P Rietberg, Challice L Bonifant.
Cytotherapy, 2018 Oct 13; 20(10). PMID: 30309710
Regulatory T cells in the treatment of disease.
Amir Sharabi, Maria G Tsokos, +3 authors, George C Tsokos.
Nat Rev Drug Discov, 2018 Oct 13; 17(11). PMID: 30310234
Highly Cited. Review.
Cancer immunotherapy: challenges and clinical applications.
An-Liang Xia, Yong Xu, Xiao-Jie Lu.
J Med Genet, 2018 Nov 23; 56(1). PMID: 30464054
Turning foes to friends: targeting cancer-associated fibroblasts.
Xueman Chen, Erwei Song.
Nat Rev Drug Discov, 2018 Nov 25; 18(2). PMID: 30470818
Highly Cited. Review.
The Yin and Yang of Myeloid Derived Suppressor Cells.
Snehil Budhwar, Priyanka Verma, +2 authors, Kiran Singh.
Front Immunol, 2018 Dec 18; 9. PMID: 30555467    Free PMC article.
Review.
Safety and clinical activity with an anti-PD-1 antibody JS001 in advanced melanoma or urologic cancer patients.
Bixia Tang, Xieqiao Yan, +20 authors, Jun Guo.
J Hematol Oncol, 2019 Jan 16; 12(1). PMID: 30642373    Free PMC article.
Highly Cited.
The evolving role of T-bet in resistance to infection.
Gretchen Harms Pritchard, Ross M Kedl, Christopher A Hunter.
Nat Rev Immunol, 2019 Mar 09; 19(6). PMID: 30846856    Free PMC article.
Review.
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion.
Deepali V Sawant, Hiroshi Yano, +16 authors, Dario A A Vignali.
Nat Immunol, 2019 Apr 03; 20(6). PMID: 30936494    Free PMC article.
Highly Cited.
TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion.
Hyungseok Seo, Joyce Chen, +12 authors, Anjana Rao.
Proc Natl Acad Sci U S A, 2019 Jun 04; 116(25). PMID: 31152140    Free PMC article.
Highly Cited.
TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma.
Xiaochen Wang, Qifeng He, +4 authors, Beicheng Sun.
J Hepatol, 2019 Jun 08; 71(4). PMID: 31173813
Highly Cited.
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion.
Omar Khan, Josephine R Giles, +22 authors, E John Wherry.
Nature, 2019 Jun 18; 571(7764). PMID: 31207603    Free PMC article.
Highly Cited.
Endothelial vascular cell adhesion molecule 1 expression is suppressed by melanoma and carcinoma.
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Immunity, 1994 Dec 01; 1(9). PMID: 7534620
Highly Cited.
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
M F Krummel, J P Allison.
J Exp Med, 1995 Aug 01; 182(2). PMID: 7543139    Free PMC article.
Highly Cited.
Inducible T cell antigen 4-1BB. Analysis of expression and function.
K E Pollok, Y J Kim, +4 authors, B S Kwon.
J Immunol, 1993 Feb 01; 150(3). PMID: 7678621
Highly Cited.
Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells.
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Highly Cited.
Viral immune evasion due to persistence of activated T cells without effector function.
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Highly Cited.
Targeted in-vitro-stimulation reveals highly proliferative multi-virus-specific human central memory T cells as candidates for prophylactic T cell therapy.
Benjamin Faist, Fabian Schlott, +11 authors, Michael Neuenhahn.
PLoS One, 2019 Oct 01; 14(9). PMID: 31568490    Free PMC article.
Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics.
Muhammad Haseeb, Rameez Hassan Pirzada, Qurat Ul Ain, Sangdun Choi.
Cells, 2019 Nov 07; 8(11). PMID: 31684152    Free PMC article.
Review.
Photochemical Internalization: Light Paves Way for New Cancer Chemotherapies and Vaccines.
Lara Šošić, Pål Kristian Selbo, +3 authors, Pål Johansen.
Cancers (Basel), 2020 Jan 16; 12(1). PMID: 31936595    Free PMC article.
Review.
T Cell Dysfunction and Exhaustion in Cancer.
Zhen Zhang, Shasha Liu, +3 authors, Yi Zhang.
Front Cell Dev Biol, 2020 Mar 03; 8. PMID: 32117960    Free PMC article.
Review.
Heterogeneity of Human γδ T Cells and Their Role in Cancer Immunity.
Hye Won Lee, Yun Shin Chung, Tae Jin Kim.
Immune Netw, 2020 Mar 12; 20(1). PMID: 32158593    Free PMC article.
Review.
Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives.
Stefania Raimondo, Marzia Pucci, Riccardo Alessandro, Simona Fontana.
Int J Mol Sci, 2020 Apr 01; 21(7). PMID: 32225076    Free PMC article.
Review.
From Theranostics to Immunotheranostics: the Concept.
Niklaus Schaefer, John O Prior, Margret Schottelius.
Nucl Med Mol Imaging, 2020 May 08; 54(2). PMID: 32377259    Free PMC article.
Review.
Immunomodulatory effects of renin-angiotensin system inhibitors on T lymphocytes in mice with colorectal liver metastases.
Dora Lucia Vallejo Ardila, Katrina A Walsh, +4 authors, Marcos Vinicius Perini.
J Immunother Cancer, 2020 May 26; 8(1). PMID: 32448803    Free PMC article.
Kaempferol and Its Glycoside, Kaempferol 7-O-Rhamnoside, Inhibit PD-1/PD-L1 Interaction In Vitro.
Ji Hye Kim, Young Soo Kim, +5 authors, Hwan-Suck Chung.
Int J Mol Sci, 2020 May 08; 21(9). PMID: 32375257    Free PMC article.
Combination of Ipilimumab and Nivolumab in Cancers: From Clinical Practice to Ongoing Clinical Trials.
Omid Kooshkaki, Afshin Derakhshani, +6 authors, Behzad Baradaran.
Int J Mol Sci, 2020 Jun 26; 21(12). PMID: 32580338    Free PMC article.
Review.
Stem cell programs in cancer initiation, progression, and therapy resistance.
Tianzhi Huang, Xiao Song, +6 authors, Shi-Yuan Cheng.
Theranostics, 2020 Aug 06; 10(19). PMID: 32754274    Free PMC article.
Review.
Lentinan Inhibits Tumor Progression by Immunomodulation in a Mouse Model of Bladder Cancer.
Ming Sun, Renge Bu, +3 authors, Wenyan Zhao.
Integr Cancer Ther, 2020 Aug 01; 19. PMID: 32735179    Free PMC article.
Immunotherapies and Combination Strategies for Immuno-Oncology.
Cody Barbari, Tyler Fontaine, +4 authors, Rahul R Deshmukh.
Int J Mol Sci, 2020 Jul 19; 21(14). PMID: 32679922    Free PMC article.
Review.
Association of Hydrophobic Carboxyl-Terminal Dendrimers with Lymph Node-Resident Lymphocytes.
Yutaka Nishimoto, Misaki Nishio, +9 authors, Chie Kojima.
Polymers (Basel), 2020 Jul 08; 12(7). PMID: 32630042    Free PMC article.
Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types.
Jasneet Kaur Khalsa, Nina Cheng, +5 authors, Khalid Shah.
Nat Commun, 2020 Aug 09; 11(1). PMID: 32764562    Free PMC article.
Automated Manufacture of Autologous CD19 CAR-T Cells for Treatment of Non-hodgkin Lymphoma.
Zachary Jackson, Anne Roe, +21 authors, Jane S Reese.
Front Immunol, 2020 Aug 28; 11. PMID: 32849651    Free PMC article.
Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma.
Jason K Sa, Nakho Chang, +32 authors, Do-Hyun Nam.
Genome Biol, 2020 Aug 28; 21(1). PMID: 32847614    Free PMC article.
"Re-educating" Tumor Associated Macrophages as a Novel Immunotherapy Strategy for Neuroblastoma.
Kevin X Liu, Shweta Joshi.
Front Immunol, 2020 Sep 29; 11. PMID: 32983125    Free PMC article.
Review.
Expression of immune checkpoints and T cell exhaustion markers in early and advanced stages of colorectal cancer.
Reem Saleh, Rowaida Z Taha, +7 authors, Eyad Elkord.
Cancer Immunol Immunother, 2020 May 13; 69(10). PMID: 32393998    Free PMC article.
Differential gene expression of tumor-infiltrating CD8+ T cells in advanced versus early-stage colorectal cancer and identification of a gene signature of poor prognosis.
Reem Saleh, Varun Sasidharan Nair, +8 authors, Eyad Elkord.
J Immunother Cancer, 2020 Sep 20; 8(2). PMID: 32948653    Free PMC article.
Spontaneous and Induced Animal Models for Cancer Research.
Anca Onaciu, Raluca Munteanu, +8 authors, Ioana Berindan-Neagoe.
Diagnostics (Basel), 2020 Sep 04; 10(9). PMID: 32878340    Free PMC article.
Review.
Helpless Priming Sends CD8+ T Cells on the Road to Exhaustion.
Julia Busselaar, Sun Tian, Hans van Eenennaam, Jannie Borst.
Front Immunol, 2020 Oct 31; 11. PMID: 33123174    Free PMC article.
Tumor Microenvironment: Implications in Melanoma Resistance to Targeted Therapy and Immunotherapy.
Italia Falcone, Fabiana Conciatori, +4 authors, Michele Milella.
Cancers (Basel), 2020 Oct 11; 12(10). PMID: 33036192    Free PMC article.
Review.
Epigenetics in modulating immune functions of stromal and immune cells in the tumor microenvironment.
Xingyi Pan, Lei Zheng.
Cell Mol Immunol, 2020 Jul 24; 17(9). PMID: 32699350    Free PMC article.
Review.
Tackling TAMs for Cancer Immunotherapy: It's Nano Time.
Yishun Yang, Jianfeng Guo, Leaf Huang.
Trends Pharmacol Sci, 2020 Sep 19; 41(10). PMID: 32946772    Free PMC article.
Review.
Exosomal PD-L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies.
Kaijian Zhou, Shu Guo, +2 authors, Guoxin Liang.
Front Cell Dev Biol, 2020 Nov 13; 8. PMID: 33178688    Free PMC article.
Review.
Distinct peripheral blood molecular signature emerges with successful tacrolimus withdrawal in kidney transplant recipients.
Paolo Cravedi, Miguel Fribourg, +7 authors, Peter S Heeger.
Am J Transplant, 2020 May 28; 20(12). PMID: 32459070    Free PMC article.
CRISPR-Based Editing Techniques for Genetic Manipulation of Primary T Cells.
Mateusz Kotowski, Sumana Sharma.
Methods Protoc, 2020 Nov 22; 3(4). PMID: 33217926    Free PMC article.
Review.
Intravital molecular imaging reveals the restrained capacity of CTLs in the killing of tumor cells in the liver.
Lei Liu, Bolei Dai, +2 authors, Zhihong Zhang.
Theranostics, 2021 Jan 05; 11(1). PMID: 33391470    Free PMC article.
Blood-based kinase activity profiling: a potential predictor of response to immune checkpoint inhibition in metastatic cancer.
Daan P Hurkmans, Els M E Verdegaal, +18 authors, Sjoerd H van der Burg.
J Immunother Cancer, 2021 Jan 12; 8(2). PMID: 33427690    Free PMC article.
The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation.
Masahiro Kiuchi, Atsushi Onodera, +8 authors, Toshinori Nakayama.
J Exp Med, 2021 Jan 13; 218(4). PMID: 33433611    Free PMC article.
The Breast Tumor Microenvironment: Could Silicone Breast Implant Elicit Breast Carcinoma?
Eduardo Fleury, Cristiane Nimir, Gabriel Salum D'Alessandro.
Breast Cancer (Dove Med Press), 2021 Jan 26; 13. PMID: 33488119    Free PMC article.
The Adhesome Network: Key Components Shaping the Tumour Stroma.
Pinelopi A Nikolopoulou, Maria A Koufaki, Vassiliki Kostourou.
Cancers (Basel), 2021 Feb 13; 13(3). PMID: 33573141    Free PMC article.
Review.
Using CRISPR to enhance T cell effector function for therapeutic applications.
Julian J Freen-van Heeren.
Cytokine X, 2021 Feb 20; 3(1). PMID: 33604565    Free PMC article.
Review.
The current landscape of single-cell transcriptomics for cancer immunotherapy.
Puneeth Guruprasad, Yong Gu Lee, Ki Hyun Kim, Marco Ruella.
J Exp Med, 2021 Feb 19; 218(1). PMID: 33601414    Free PMC article.
Review.
Colony-stimulating factor 3 signaling in colon and rectal cancers: Immune response and CMS classification in TCGA data.
Apryl S Saunders, Dawn E Bender, +2 authors, Katherine T Morris.
PLoS One, 2021 Feb 20; 16(2). PMID: 33606788    Free PMC article.
Ubiquitination of Nonhistone Proteins in Cancer Development and Treatment.
Xiuzhen Zhang, Tong Meng, +4 authors, Ping Wang.
Front Oncol, 2021 Mar 02; 10. PMID: 33643919    Free PMC article.
Review.
Low-grade chronic inflammation and immune alterations in childhood and adolescent cancer survivors: A contribution to accelerated aging?
Joanna Sulicka-Grodzicka, Andrzej Surdacki, +4 authors, Tomasz Grodzicki.
Cancer Med, 2021 Feb 20; 10(5). PMID: 33605556    Free PMC article.
A New Method for Optimizing Sepsis Therapy by Nivolumab and Meropenem Combination: Importance of Early Intervention and CTL Reinvigoration Rate as a Response Marker.
Avi Gillis, Anat Ben Yaacov, Zvia Agur.
Front Immunol, 2021 Mar 19; 12. PMID: 33732241    Free PMC article.
Lipid Metabolism in Tumor-Infiltrating T Cells.
Shangwen He, Ting Cai, +2 authors, Wei Yang.
Adv Exp Med Biol, 2021 Mar 20; 1316. PMID: 33740249
Next generation of immune checkpoint inhibitors and beyond.
Julian A Marin-Acevedo, ErinMarie O Kimbrough, Yanyan Lou.
J Hematol Oncol, 2021 Mar 21; 14(1). PMID: 33741032    Free PMC article.
Review.
Low-Dose Decitabine Augments the Activation and Anti-Tumor Immune Response of IFN-γ+ CD4+ T Cells Through Enhancing IκBα Degradation and NF-κB Activation.
Xiang Li, Liang Dong, +6 authors, Jing Nie.
Front Cell Dev Biol, 2021 Apr 02; 9. PMID: 33791306    Free PMC article.
Progression of Metastasis through Lymphatic System.
Hengbo Zhou, Pin-Ji Lei, Timothy P Padera.
Cells, 2021 Apr 04; 10(3). PMID: 33808959    Free PMC article.
Review.
Nanoparticles for Enhanced Adoptive T Cell Therapies and Future Perspectives for CNS Tumors.
Preethi Bala Balakrishnan, Elizabeth E Sweeney.
Front Immunol, 2021 Apr 10; 12. PMID: 33833751    Free PMC article.
Review.
Understanding the Immune-Stroma Microenvironment in B Cell Malignancies for Effective Immunotherapy.
Benedetta Apollonio, Nikolaos Ioannou, Despoina Papazoglou, Alan G Ramsay.
Front Oncol, 2021 Apr 13; 11. PMID: 33842331    Free PMC article.
Review.
Small molecule inhibitors against PD-1/PD-L1 immune checkpoints and current methodologies for their development: a review.
Chang Liu, Navindra P Seeram, Hang Ma.
Cancer Cell Int, 2021 Apr 29; 21(1). PMID: 33906641    Free PMC article.
Review.
Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity.
Won Suk Lee, Hannah Yang, Hong Jae Chon, Chan Kim.
Exp Mol Med, 2020 Sep 12; 52(9). PMID: 32913278    Free PMC article.
Review.
Tissues and Tumor Microenvironment (TME) in 3D: Models to Shed Light on Immunosuppression in Cancer.
Teresa Ho, Rasha Msallam.
Cells, 2021 May 01; 10(4). PMID: 33917037    Free PMC article.
Review.
Ex Vivo High Salt Activated Tumor-Primed CD4+T Lymphocytes Exert a Potent Anti-Cancer Response.
Venkataswarup Tiriveedhi, Michael T Ivy, +3 authors, Jens Titze.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33918403    Free PMC article.
A Review of Proteomics Strategies to Study T-Cell Activation and Function in Cancer Disease.
Massimo Papale.
Methods Mol Biol, 2021 May 31; 2325. PMID: 34053055
Review.
Recent Advances on Immune Targeted Therapy of Colorectal Cancer Using bi-Specific Antibodies and Therapeutic Vaccines.
Ali Azadi, Alireza Golchini, +4 authors, Shirin Eyvazi.
Biol Proced Online, 2021 Jul 02; 23(1). PMID: 34193050    Free PMC article.
Review.
Prognostic Value of Galectin-9 Relates to Programmed Death-Ligand 1 in Patients With Multiple Myeloma.
Byung-Hyun Lee, Yong Park, +4 authors, Byung Soo Kim.
Front Oncol, 2021 Jul 02; 11. PMID: 34195077    Free PMC article.
Resistance to immune checkpoint inhibitors in advanced gastro-oesophageal cancers.
Mark A Baxter, Fearghas Middleton, Hannah P Cagney, Russell D Petty.
Br J Cancer, 2021 Jul 08; 125(8). PMID: 34230609    Free PMC article.
Review.
T Cell Defects and Immunotherapy in Chronic Lymphocytic Leukemia.
Elisavet Vlachonikola, Kostas Stamatopoulos, Anastasia Chatzidimitriou.
Cancers (Basel), 2021 Jul 03; 13(13). PMID: 34209724    Free PMC article.
Review.
The Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy.
Bonnie L Russell, Selisha A Sooklal, +2 authors, Monde Ntwasa.
Front Oncol, 2021 Jul 17; 11. PMID: 34268109    Free PMC article.
Review.
Beyond Just Peptide Antigens: The Complex World of Peptide-Based Cancer Vaccines.
Alexander J Stephens, Nicola A Burgess-Brown, Shisong Jiang.
Front Immunol, 2021 Jul 20; 12. PMID: 34276688    Free PMC article.
Review.
The therapeutic and prognostic implications of immunobiology in colorectal cancer: a review.
Alexandra M Zaborowski, Des C Winter, Lydia Lynch.
Br J Cancer, 2021 Jul 25; 125(10). PMID: 34302062    Free PMC article.
Review.
Classification of Lung Adenocarcinoma Based on Immune Checkpoint and Screening of Related Genes.
Ting Zhou, Ping Yang, +6 authors, Liang Li.
J Oncol, 2021 Aug 10; 2021. PMID: 34367284    Free PMC article.
Cellular based immunotherapy for primary liver cancer.
Yuanyuan Zheng, Yan Li, +8 authors, Chuanyong Guo.
J Exp Clin Cancer Res, 2021 Aug 11; 40(1). PMID: 34372912    Free PMC article.
Review.
Dynamic chromatin regulatory landscape of human CAR T cell exhaustion.
David G Gennert, Rachel C Lynn, +10 authors, Howard Y Chang.
Proc Natl Acad Sci U S A, 2021 Jul 22; 118(30). PMID: 34285077    Free PMC article.
An Engineered Prussian Blue Nanoparticles-based Nanoimmunotherapy Elicits Robust and Persistent Immunological Memory in a TH-MYCN Neuroblastoma Model.
Anshi Shukla, Juliana Cano-Mejia, +3 authors, Rohan Fernandes.
Adv Nanobiomed Res, 2021 Aug 27; 1(8). PMID: 34435194    Free PMC article.
Novel Insights into the Immunotherapy of Soft Tissue Sarcomas: Do We Need a Change of Perspective?
Andrej Ozaniak, Jiri Vachtenheim, +2 authors, Zuzana Strizova.
Biomedicines, 2021 Aug 28; 9(8). PMID: 34440139    Free PMC article.
Review.
Novel diagnostic and prognostic biomarkers of colorectal cancer: Capable to overcome the heterogeneity-specific barrier and valid for global applications.
Yasir Hameed, Muhammad Usman, Shufang Liang, Samina Ejaz.
PLoS One, 2021 Sep 03; 16(9). PMID: 34473751    Free PMC article.
Carrelizumab combined with anlotinib in the treatment of extensive-stage small cell lung cancer: A case report.
Liang Liu, Xin Zhang, +3 authors, Xiaodong Jiang.
Medicine (Baltimore), 2021 Sep 04; 100(35). PMID: 34477165    Free PMC article.
MMP25-AS1/hsa-miR-10a-5p/SERPINE1 axis as a novel prognostic biomarker associated with immune cell infiltration in KIRC.
Peng Tan, Hao Chen, +6 authors, Wenguang Fu.
Mol Ther Oncolytics, 2021 Sep 24; 22. PMID: 34553021    Free PMC article.
Cytomegalovirus retinitis in patients of non-Hodgkin's lymphoma: clinical presentations and outcomes.
Subhakar Reddy, Mudit Tyagi, +4 authors, Hitesh Agrawal.
J Ophthalmic Inflamm Infect, 2021 Oct 07; 11(1). PMID: 34611773    Free PMC article.
Improving CAR T-Cell Persistence.
Violena Pietrobon, Lauren Anne Todd, +3 authors, Francesco Marincola.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34639168    Free PMC article.
Review.
Dietary Fats High in Linoleic Acids Impair Antitumor T-cell Responses by Inducing E-FABP-Mediated Mitochondrial Dysfunction.
Rong Jin, Jiaqing Hao, +8 authors, Bing Li.
Cancer Res, 2021 Aug 18; 81(20). PMID: 34400394    Free PMC article.
Multifunctional silica nanocomposites prime tumoricidal immunity for efficient cancer immunotherapy.
Linnan Yang, Feng Li, +7 authors, Ang Li.
J Nanobiotechnology, 2021 Oct 20; 19(1). PMID: 34663354    Free PMC article.
CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer?
Alexandra M Miggelbrink, Joshua D Jackson, +4 authors, Peter E Fecci.
Clin Cancer Res, 2021 Jun 16; 27(21). PMID: 34127507    Free PMC article.
Review.
Distinct roles but cooperative effect of TLR3/9 agonists and PD-1 blockade in converting the immunotolerant microenvironment of irreversible electroporation-ablated tumors.
Fatma Babikr, Jiangbo Wan, +10 authors, Jim Xiang.
Cell Mol Immunol, 2021 Nov 17; 18(12). PMID: 34782757    Free PMC article.
Drug-eluting immune checkpoint blockade antibody-nanoparticle conjugate enhances locoregional and systemic combination cancer immunotherapy through T lymphocyte targeting.
David M Francis, Margaret P Manspeaker, +4 authors, Susan N Thomas.
Biomaterials, 2021 Oct 23; 279. PMID: 34678650    Free PMC article.
T Cell Immune Profiles of Blood and Tumor in Dogs Diagnosed With Malignant Melanoma.
Ellen E Sparger, Hong Chang, +6 authors, Michael S Kent.
Front Vet Sci, 2021 Dec 21; 8. PMID: 34926643    Free PMC article.
Resistance to Immunotherapy: Mechanisms and Means for Overcoming.
Mohamad A Salkeni, John Y Shin, James L Gulley.
Adv Exp Med Biol, 2022 Jan 02; 1342. PMID: 34972962
Targeting the ERβ/HER Oncogenic Network in KRAS Mutant Lung Cancer Modulates the Tumor Microenvironment and Is Synergistic with Sequential Immunotherapy.
Abdulaziz A Almotlak, Mariya Farooqui, +2 authors, Laura P Stabile.
Int J Mol Sci, 2022 Jan 12; 23(1). PMID: 35008514    Free PMC article.
Signatures and Specificity of Tissue-Resident Lymphocytes Identified in Human Renal Peritumor and Tumor Tissue.
Theresa Dornieden, Arne Sattler, +10 authors, Katja Kotsch.
J Am Soc Nephrol, 2021 Jun 03; 32(9). PMID: 34074699    Free PMC article.
T cells in pancreatic cancer stroma.
Michelle R Goulart, Konstantinos Stasinos, +2 authors, Hemant M Kocher.
World J Gastroenterol, 2022 Jan 21; 27(46). PMID: 35046623    Free PMC article.
Review.
Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1.
Dafne C A Quixabeira, Victor Cervera-Carrascon, +9 authors, Akseli Hemminki.
Oncoimmunology, 2022 Jan 28; 11(1). PMID: 35083096    Free PMC article.
Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumor immunity.
Máté Manczinger, Balázs Koncz, +5 authors, Csaba Pál.
Nat Cancer, 2022 Feb 06; 2(9). PMID: 35121862
Impaired CXCL12 signaling contributes to resistance of pancreatic cancer subpopulations to T cell-mediated cytotoxicity.
Yuan-Na Lin, Marcel O Schmidt, +5 authors, Anton Wellstein.
Oncoimmunology, 2022 Feb 08; 11(1). PMID: 35127250    Free PMC article.
Machine Learning of Single Cell Transcriptomic Data From anti-PD-1 Responders and Non-responders Reveals Distinct Resistance Mechanisms in Skin Cancers and PDAC.
Ryan Liu, Emmanuel Dollinger, Qing Nie.
Front Genet, 2022 Feb 19; 12. PMID: 35178072    Free PMC article.
Circadian and Immunity Cycle Talk in Cancer Destination: From Biological Aspects to In Silico Analysis.
Mina Mirian, Amirali Hariri, Mahtasadat Yadollahi, Mohammad Kohandel.
Cancers (Basel), 2022 Mar 26; 14(6). PMID: 35326729    Free PMC article.
Review.
Selective Targeting of Protein Kinase C (PKC)-θ Nuclear Translocation Reduces Mesenchymal Gene Signatures and Reinvigorates Dysfunctional CD8+ T Cells in Immunotherapy-Resistant and Metastatic Cancers.
Jenny Dunn, Robert D McCuaig, +22 authors, Sudha Rao.
Cancers (Basel), 2022 Mar 26; 14(6). PMID: 35326747    Free PMC article.
Role of Senescence in Tumorigenesis and Anticancer Therapy.
Ewelina Stoczynska-Fidelus, Marta Węgierska, +2 authors, Piotr Rieske.
J Oncol, 2022 Mar 29; 2022. PMID: 35342397    Free PMC article.
Review.
CD8+ T Cells in SARS-CoV-2 Induced Disease and Cancer-Clinical Perspectives.
Keywan Mortezaee, Jamal Majidpoor.
Front Immunol, 2022 Apr 19; 13. PMID: 35432340    Free PMC article.
Review.
Visual Analysis of Colorectal Cancer Immunotherapy: A Bibliometric Analysis From 2012 to 2021.
Long Ma, Jixiang Ma, Muzhou Teng, Yumin Li.
Front Immunol, 2022 Apr 19; 13. PMID: 35432385    Free PMC article.
Efficacy and security of tumor vaccines for hepatocellular carcinoma: a systemic review and meta-analysis of the last 2 decades.
Cheng-Long Han, Yu-Chuan Yan, +8 authors, Tao Li.
J Cancer Res Clin Oncol, 2022 Apr 29;. PMID: 35482077
Immune checkpoint inhibitors for the treatment of melanoma.
Francesco Sabbatino, Luigi Liguori, Stefano Pepe, Soldano Ferrone.
Expert Opin Biol Ther, 2022 Feb 09; 22(5). PMID: 35130816    Free PMC article.
Review.
Advanced Immune Cell Profiling by Multiparameter Flow Cytometry in Humanized Patient-Derived Tumor Mice.
Christina Bruss, Kerstin Kellner, +4 authors, Anja Kathrin Wege.
Cancers (Basel), 2022 May 15; 14(9). PMID: 35565343    Free PMC article.