Review
. 2019 Aug;20(1).
doi: 10.1038/s41577-019-0210-z.

Dendritic cells in cancer immunology and immunotherapy

Stefanie K Wculek 1 Francisco J Cueto 1 Adriana M Mujal 2 Ignacio Melero 3 Matthew F Krummel 2 David Sancho 4 
Affiliations
  • PMID: 31467405
  •     136 citations

Abstract

Dendritic cells (DCs) are a diverse group of specialized antigen-presenting cells with key roles in the initiation and regulation of innate and adaptive immune responses. As such, there is currently much interest in modulating DC function to improve cancer immunotherapy. Many strategies have been developed to target DCs in cancer, such as the administration of antigens with immunomodulators that mobilize and activate endogenous DCs, as well as the generation of DC-based vaccines. A better understanding of the diversity and functions of DC subsets and of how these are shaped by the tumour microenvironment could lead to improved therapies for cancer. Here we will outline how different DC subsets influence immunity and tolerance in cancer settings and discuss the implications for both established cancer treatments and novel immunotherapy strategies.

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Immunotherapy of Tumor RNA-Loaded Lipid Nanoparticles Against Hepatocellular Carcinoma.
Yake Zhang, Fangyuan Xie, +6 authors, Jie Gao.
Int J Nanomedicine, 2021 Mar 05; 16. PMID: 33658783    Free PMC article.
Case Report: Transformation From Cold to Hot Tumor in a Case of NSCLC Neoadjuvant Immunochemotherapy Pseudoprogression.
Wenxiao Jia, Hui Zhu, +5 authors, Jinming Yu.
Front Immunol, 2021 Mar 09; 12. PMID: 33679783    Free PMC article.
Personalized cancer vaccination in head and neck cancer.
Hirofumi Shibata, Liye Zhou, +2 authors, Ravindra Uppaluri.
Cancer Sci, 2020 Dec 29; 112(3). PMID: 33368875    Free PMC article.
Review.
Perspectives on Oncolytic Salmonella in Cancer Immunotherapy-A Promising Strategy.
Ding Wang, Xiaodong Wei, +2 authors, Ling Zhang.
Front Immunol, 2021 Mar 16; 12. PMID: 33717106    Free PMC article.
Review.
Improvement of DC-based vaccines using adjuvant TLR4-binding 60S acidic ribosomal protein P2 and immune checkpoint inhibitors.
Gun-Young Jang, Young Seob Kim, +4 authors, Yeong-Min Park.
Cancer Immunol Immunother, 2020 Oct 29; 70(4). PMID: 33113002
Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy.
Xin Peng, Youe He, +2 authors, Shuang Liu.
Front Immunol, 2021 Mar 19; 12. PMID: 33732237    Free PMC article.
Review.
Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion.
Suchit Jhunjhunwala, Christian Hammer, Lélia Delamarre.
Nat Rev Cancer, 2021 Mar 23;. PMID: 33750922
Review.
Regulatory T cells in ischemic stroke.
Hong-Yun Wang, Jun-Rui Ye, +2 authors, Nai-Hong Chen.
Acta Pharmacol Sin, 2021 Mar 28;. PMID: 33772140
Review.
The Multifaceted Role of Th1, Th9, and Th17 Cells in Immune Checkpoint Inhibition Therapy.
Jongdae Lee, Beatriz Lozano-Ruiz, +3 authors, Jose M González-Navajas.
Front Immunol, 2021 Mar 30; 12. PMID: 33777008    Free PMC article.
Review.
The Crosstalk Between Tumor Cells and the Immune Microenvironment in Breast Cancer: Implications for Immunotherapy.
Vincenzo Salemme, Giorgia Centonze, +2 authors, Laura Conti.
Front Oncol, 2021 Mar 30; 11. PMID: 33777750    Free PMC article.
Review.
Cell Division Cycle Associated Genes as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma.
Shan-Shan Jiang, Sheng-Jie Ke, +3 authors, Xing-Wei Xie.
Front Mol Biosci, 2021 Mar 30; 8. PMID: 33778011    Free PMC article.
Cyclophosphamide loaded thermo-responsive hydrogel system synergize with a hydrogel cancer vaccine to amplify cancer immunotherapy in a prime-boost manner.
Fan Yang, Kun Shi, +7 authors, Zhiyong Qian.
Bioact Mater, 2021 Mar 30; 6(10). PMID: 33778186    Free PMC article.
Human CD141+ dendritic cells (cDC1) are impaired in patients with advanced melanoma but can be targeted to enhance anti-PD-1 in a humanized mouse model.
Yoke Seng Lee, Liam J O'Brien, +6 authors, Kristen J Radford.
J Immunother Cancer, 2021 Mar 20; 9(3). PMID: 33737342    Free PMC article.
Enhancing Cancer Immunotherapy Treatment Goals by Using Nanoparticle Delivery System.
Tobias Achu Muluh, Zhuo Chen, +4 authors, JingBo Wu.
Int J Nanomedicine, 2021 Apr 02; 16. PMID: 33790556    Free PMC article.
Review.
Development of an Inflammatory CD14+ Dendritic Cell Subset in Humanized Mice.
Ryutaro Iwabuchi, Keigo Ide, +6 authors, Yoshimasa Takahashi.
Front Immunol, 2021 Apr 02; 12. PMID: 33790912    Free PMC article.
Integrative Analysis of the Expression of SIGLEC Family Members in Lung Adenocarcinoma via Data Mining.
Haiyan Zhang, Yongfei Xie, +6 authors, Qing Yuan.
Front Oncol, 2021 Apr 03; 11. PMID: 33796453    Free PMC article.
Functions of Dendritic Cells and Its Association with Intestinal Diseases.
Ze-Jun Yang, Bo-Ya Wang, +6 authors, Jing-Dong Xu.
Cells, 2021 Apr 04; 10(3). PMID: 33800865    Free PMC article.
Review.
The Peripheral Immune Landscape of Breast Cancer: Clinical Findings and In Vitro Models for Biomarker Discovery.
Sofia Batalha, Sofia Ferreira, Catarina Brito.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33804027    Free PMC article.
Review.
Primary Human Dendritic Cells and Whole-Blood Based Assays to Evaluate Immuno-Modulatory Properties of Heat-Killed Commensal Bacteria.
James E Norton, Sushma Kommineni, +3 authors, Gokul Swaminathan.
Vaccines (Basel), 2021 Apr 04; 9(3). PMID: 33807734    Free PMC article.
High dimensional immunotyping of tumors grown in obese and non-obese mice.
Cara E Wogsland, Hilde E Lien, +5 authors, Nils Halberg.
Dis Model Mech, 2021 Mar 04;. PMID: 33653826    Free PMC article.
Strategies to Potentiate Paracrine Therapeutic Efficacy of Mesenchymal Stem Cells in Inflammatory Diseases.
Yoojin Seo, Min-Jung Kang, Hyung-Sik Kim.
Int J Mol Sci, 2021 Apr 04; 22(7). PMID: 33806241    Free PMC article.
Review.
PTBP1 is necessary for dendritic cells to regulate T-cell homeostasis and antitumour immunity.
Guangfeng Geng, Changlu Xu, +6 authors, Lihong Shi.
Immunology, 2021 Jan 10; 163(1). PMID: 33421118    Free PMC article.
Role of serotonin receptor signaling in cancer cells and anti-tumor immunity.
Surojit Karmakar, Girdhari Lal.
Theranostics, 2021 Apr 17; 11(11). PMID: 33859748    Free PMC article.
Review.
Tumor-infiltrating plasmacytoid dendritic cells are associated with survival in human colon cancer.
Maximilian Kießler, Ioana Plesca, +16 authors, Marc Schmitz.
J Immunother Cancer, 2021 Mar 26; 9(3). PMID: 33762320    Free PMC article.
Apatinib combined with PD-L1 blockade synergistically enhances antitumor immune responses and promotes HEV formation in gastric cancer.
Yu Zhang, Fei Wang, +3 authors, Hua Huang.
J Cancer Res Clin Oncol, 2021 Apr 24;. PMID: 33891173
The Role of Metabolism in Tumor Immune Evasion: Novel Approaches to Improve Immunotherapy.
Alberto Cruz-Bermúdez, Raquel Laza-Briviesca, +2 authors, Mariano Provencio.
Biomedicines, 2021 Apr 04; 9(4). PMID: 33807260    Free PMC article.
Review.
Enhanced anti-melanoma efficacy through a combination of the armed oncolytic adenovirus ZD55-IL-24 and immune checkpoint blockade in B16-bearing immunocompetent mouse model.
Hai-Jun Hu, Xiu Liang, +7 authors, Xin-Yuan Liu.
Cancer Immunol Immunother, 2021 Apr 28;. PMID: 33903973
Therapeutic cancer vaccines.
Mansi Saxena, Sjoerd H van der Burg, Cornelis J M Melief, Nina Bhardwaj.
Nat Rev Cancer, 2021 Apr 29;. PMID: 33907315
Review.