Review
. 2019 Oct; 12(2):e1588.
doi: 10.1002/wnan.1588.

Critical considerations for targeting colorectal liver metastases with nanotechnology

Usman Arshad 1 Paul A Sutton 2 Marianne B Ashford 3 Kevin E Treacher 4 Neill J Liptrott 5 Steve P Rannard 6 Christopher E Goldring 7 Andrew Owen 5 
Affiliations
  • PMID: 31566913
  •     167 References
  •     4 citations

Abstract

Colorectal cancer remains a significant cause of morbidity and mortality worldwide. Half of all patients develop liver metastases, presenting unique challenges for their treatment. The shortcomings of conventional chemotherapy has encouraged the use of nanomedicines; the application of nanotechnology in the diagnosis and treatment of disease. In spite of technological improvements in nanotechnology, the complexity of biological systems hinders the prospect of nanomedicines being applied in cancer therapy at the present time. This review highlights current biological barriers and discusses aspects of tumor biology together with the physicochemical features of the nanocarrier, that need to be considered in order to develop effective nanotherapeutics for colorectal cancer patients with liver metastases. It becomes clear that incorporating an interdisciplinary approach when developing nanomedicines should assure appropriate disease-driven design and that this will form a critical step in improving their clinical translation. This article is characterized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

Keywords: colorectal cancer; drug delivery; liver metastases; nanomedicines; tumor biology.

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Liver Metastases and Histological Growth Patterns: Biological Behavior and Potential Clinical Implications-Another Path to Individualized Medicine?
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Fabrication of Charge-Conversion Nanoparticles for Cancer Imaging by Flash Nanoprecipitation.
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Cooperative transmembrane penetration of nanoparticles.
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Polyethylene glycol reactive antibodies in man: titer distribution in allergic patients treated with monomethoxy polyethylene glycol modified allergens or placebo, and in healthy blood donors.
A W Richter, E Akerblom.
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Kupffer cells are central in the removal of nanoparticles from the organism.
Evaldas Sadauskas, Håkan Wallin, +4 authors, Gorm Danscher.
Part Fibre Toxicol, 2007 Oct 24; 4. PMID: 17949501    Free PMC article.
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Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications.
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Am J Pathol, 2007 Jan 04; 170(1). PMID: 17200177    Free PMC article.
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Subcutaneous Inoculation of 3D Pancreatic Cancer Spheroids Results in Development of Reproducible Stroma-Rich Tumors.
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Understanding the Role of Anti-PEG Antibodies in the Complement Activation by Doxil in Vitro.
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Comprehensively priming the tumor microenvironment by cancer-associated fibroblast-targeted liposomes for combined therapy with cancer cell-targeted chemotherapeutic drug delivery system.
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Engineering of near IR fluorescent albumin nanoparticles for in vivo detection of colon cancer.
Sarit Cohen, Shlomo Margel.
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Tumor Site-Dependent Transport Properties Determine Nanotherapeutics Delivery and Its Efficacy.
Megumi Kai, Arturas Ziemys, +3 authors, Kenji Yokoi.
Transl Oncol, 2019 Jun 23; 12(9). PMID: 31228770    Free PMC article.
Critical considerations for targeting colorectal liver metastases with nanotechnology.
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Lipid-Based Drug Delivery Nanoplatforms for Colorectal Cancer Therapy.
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Pathological significance of abnormal recepteur d'origine nantais and programmed death ligand 1 expression in colorectal cancer.
Yi-Zhi Liu, Da-Ting Han, +8 authors, Hang-Ping Yao.
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Therapeutic Approaches for Metastases from Colorectal Cancer and Pancreatic Ductal Carcinoma.
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