. 2019 Oct;394(10207).
doi: 10.1016/S0140-6736(19)32319-0.

Colorectal cancer

Evelien Dekker 1 Pieter J Tanis 2 Jasper L A Vleugels 3 Pashtoon M Kasi 4 Michael B Wallace 5 
  • PMID: 31631858
  •     251 citations


Several decades ago, colorectal cancer was infrequently diagnosed. Nowadays, it is the world's fourth most deadly cancer with almost 900 000 deaths annually. Besides an ageing population and dietary habits of high-income countries, unfavourable risk factors such as obesity, lack of physical exercise, and smoking increase the risk of colorectal cancer. Advancements in pathophysiological understanding have increased the array of treatment options for local and advanced disease leading to individual treatment plans. Treatments include endoscopic and surgical local excision, downstaging preoperative radiotherapy and systemic therapy, extensive surgery for locoregional and metastatic disease, local ablative therapies for metastases, and palliative chemotherapy, targeted therapy, and immunotherapy. Although these new treatment options have doubled overall survival for advanced disease to 3 years, survival is still best for those with non-metastasised disease. As the disease only becomes symptomatic at an advanced stage, worldwide organised screening programmes are being implemented, which aim to increase early detection and reduce morbidity and mortality from colorectal cancer.

Precise Personalized Medicine in Gynecology Cancer and Infertility.
Pu-Yao Zhang, Yang Yu.
Front Cell Dev Biol, 2020 Feb 06; 7. PMID: 32010694    Free PMC article.
BRAF mutant colorectal cancer: ErbB2 expression levels as predictive factor for the response to combined BRAF/ErbB inhibitors.
Evelina Miele, Luana Abballe, +7 authors, Elisabetta Ferretti.
BMC Cancer, 2020 Feb 19; 20(1). PMID: 32066410    Free PMC article.
Integrated characterization and validation of the prognostic significance of microRNA-200s in colorectal cancer.
Qiliang Peng, Ming Cheng, +4 authors, Bo Xu.
Cancer Cell Int, 2020 Feb 27; 20. PMID: 32099529    Free PMC article.
C20orf27 Promotes Cell Growth and Proliferation of Colorectal Cancer via the TGFβR-TAK1-NFĸB Pathway.
Jing Gao, Yang Wang, +6 authors, Qing-Yu He.
Cancers (Basel), 2020 Feb 07; 12(2). PMID: 32024300    Free PMC article.
Targeting Epidermal Growth Factor Receptor (EGFR) in Pediatric Colorectal Cancer.
Maria Debora De Pasquale, Alessandro Crocoli, +6 authors, Evelina Miele.
Cancers (Basel), 2020 Feb 15; 12(2). PMID: 32053874    Free PMC article.
Analysis of Killer Immunoglobulin-Like Receptor Genes in Colorectal Cancer.
Roberto Diaz-Peña, Patricia Mondelo-Macía, +3 authors, Vicente Martín.
Cells, 2020 Feb 28; 9(2). PMID: 32102404    Free PMC article.
Schizandrin A exhibits potent anticancer activity in colorectal cancer cells by inhibiting heat shock factor 1.
Bing-Chen Chen, Shi-Liang Tu, +3 authors, Qiao-Qiong Dai.
Biosci Rep, 2020 Feb 29; 40(3). PMID: 32110802    Free PMC article.
Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling.
Chi-Hung R Or, Chiao-Wen Huang, +3 authors, Chia-Che Chang.
Int J Mol Sci, 2020 Mar 11; 21(5). PMID: 32150830    Free PMC article.
ASPP1 deficiency promotes epithelial-mesenchymal transition, invasion and metastasis in colorectal cancer.
Dian Liu, Ayse Ertay, +9 authors, Yihua Wang.
Cell Death Dis, 2020 Apr 10; 11(4). PMID: 32269211    Free PMC article.
Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models.
Thangirala Sudha, Ali H El-Far, Deena S Mousa, Shaker A Mousa.
Molecules, 2020 Apr 05; 25(6). PMID: 32244860    Free PMC article.
Trichomicin Suppresses Colorectal Cancer via Comprehensive Regulation of IL-6 and TNFα in Tumor Cells, TAMs, and CAFs.
Xi Zhao, Xiaoqiang Qi, +7 authors, Liping Bai.
Front Pharmacol, 2020 Apr 23; 11. PMID: 32317968    Free PMC article.
Application of weighted gene co‑expression network analysis to explore the potential diagnostic biomarkers for colorectal cancer.
Liping Qin, Jianping Zeng, +2 authors, Li Wang.
Mol Med Rep, 2020 Apr 24; 21(6). PMID: 32323816    Free PMC article.
Spatial access to primary care providers and colorectal cancer-specific survival in Cook County, Illinois.
Vincent L Freeman, Keith B Naylor, +5 authors, Sara L McLafferty.
Cancer Med, 2020 Mar 05; 9(9). PMID: 32130791    Free PMC article.
Robotic- vs laparoscopic-assisted proctectomy for locally advanced rectal cancer based on propensity score matching: Short-term outcomes at a colorectal center in China.
Shan-Ping Ye, Wei-Quan Zhu, +9 authors, Tai-Yuan Li.
World J Gastrointest Oncol, 2020 May 06; 12(4). PMID: 32368320    Free PMC article.
Integrating Genome-Wide Association Studies and Gene Expression Profiles With Chemical-Genes Interaction Networks to Identify Chemicals Associated With Colorectal Cancer.
Xinyue Tan, Hanmin Tang, +6 authors, Suxia Han.
Front Genet, 2020 May 12; 11. PMID: 32391058    Free PMC article.
Overcoming resistance to anti-PD1 and anti-PD-L1 treatment in gastrointestinal malignancies.
Alberto Puccini, Francesca Battaglin, +2 authors, Mohamed E Salem.
J Immunother Cancer, 2020 May 13; 8(1). PMID: 32393474    Free PMC article.
The Role of Cyclooxygenase-2 in Colorectal Cancer.
Juan Sheng, Hong Sun, +3 authors, Ying-Ting Zhu.
Int J Med Sci, 2020 May 16; 17(8). PMID: 32410839    Free PMC article.
Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders: Useful Nutraceuticals?
Vicente Martínez, Amaia Iriondo De-Hond, +3 authors, Raquel Abalo.
Int J Mol Sci, 2020 May 03; 21(9). PMID: 32357565    Free PMC article.
IL-8 mediates a positive loop connecting increased neutrophil extracellular traps (NETs) and colorectal cancer liver metastasis.
Luyu Yang, Lu Liu, +7 authors, Hankun Hao.
J Cancer, 2020 Jun 04; 11(15). PMID: 32489457    Free PMC article.
Clinical Significances of Positive Postoperative Serum CEA and Post-preoperative CEA Increment in Stage II and III Colorectal Cancer: A Multicenter Retrospective Study.
Weiqiang You, Li Yan, +5 authors, Zhigang Wang.
Front Oncol, 2020 Jun 09; 10. PMID: 32509572    Free PMC article.
The fiber metabolite butyrate reduces gp130 by targeting TRAF5 in colorectal cancer cells.
Yin Yuan, Bo Li, +13 authors, Lanjuan Li.
Cancer Cell Int, 2020 Jun 11; 20. PMID: 32518521    Free PMC article.
KLF13 suppresses the proliferation and growth of colorectal cancer cells through transcriptionally inhibiting HMGCS1-mediated cholesterol biosynthesis.
Weilong Yao, Yue Jiao, Yanhua Zhou, Xiaoya Luo.
Cell Biosci, 2020 Jun 12; 10. PMID: 32523679    Free PMC article.
MICA Allele Facilitates the Metastasis of KRAS-Mutant Colorectal Cancer.
Weifeng Ding, Yanyun Ma, +8 authors, Xiaodong Zhou.
Front Genet, 2020 Jun 13; 11. PMID: 32528529    Free PMC article.
Suboptimal endoscopic cancer recognition in colorectal lesions in a national bowel screening programme.
Jasper L A Vleugels, Lianne Koens, +5 authors, DISCOUNT study group.
Gut, 2019 Dec 12; 69(6). PMID: 31822579    Free PMC article.
Suppression of PKCδ/NF-κB Signaling and Apoptosis Induction through Extrinsic/Intrinsic Pathways Are Associated Magnolol-Inhibited Tumor Progression in Colorectal Cancer In Vitro and In Vivo.
Chun-Min Su, Yueh-Shan Weng, +2 authors, Fei-Ting Hsu.
Int J Mol Sci, 2020 May 21; 21(10). PMID: 32429376    Free PMC article.
Clinicopathological significance of Ki67 expression in colorectal cancer: A protocol of systematic review and meta-analysis.
Jing Li, Zhi-Ye Liu, +3 authors, Hai-Tao Yu.
Medicine (Baltimore), 2020 May 24; 99(20). PMID: 32443327    Free PMC article.
Systematic Review.
Impact of cuff-assisted colonoscopy for adenoma detection: A protocol of systematic review and meta-analysis.
Qi Li, Hai-de Gao, +4 authors, Xian-Kai Zhang.
Medicine (Baltimore), 2020 May 24; 99(20). PMID: 32443361    Free PMC article.
Application of the chemokine-chemokine receptor axis increases the tumor-targeted migration ability of cytokine-induced killer cells in patients with colorectal cancer.
Yunlian Zou, Jianhua Liang, +7 authors, Hui Tang.
Oncol Lett, 2020 Jun 23; 20(1). PMID: 32565940    Free PMC article.
Downregulation of CLCA4 expression is associated with the development and progression of colorectal cancer.
Lihui Wei, Wujin Chen, +2 authors, Jiumao Lin.
Oncol Lett, 2020 Jun 23; 20(1). PMID: 32565987    Free PMC article.
Clinicopathological Characteristics and Mutation Spectrum of Colorectal Adenocarcinoma With Mucinous Component in a Chinese Cohort: Comparison With Classical Adenocarcinoma.
Jingci Chen, Liangrui Zhou, +4 authors, Zhiyong Liang.
Front Oncol, 2020 Jun 26; 10. PMID: 32582557    Free PMC article.
Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Essential Oils: Implications in Colonic Pathophysiology.
Enzo Spisni, Giovannamaria Petrocelli, +5 authors, Maria Chiara Valerii.
Int J Mol Sci, 2020 Jun 14; 21(11). PMID: 32532055    Free PMC article.
Lnc-HSD17B11-1:1 Functions as a Competing Endogenous RNA to Promote Colorectal Cancer Progression by Sponging miR-338-3p to Upregulate MACC1.
Wei Zhang, Bo Wang, +5 authors, Shan Wang.
Front Genet, 2020 Jul 01; 11. PMID: 32595704    Free PMC article.
Predicting liver and lung metastasis in esophageal cancer: does the site of primary tumor really matter?
Ka-On Lam, Tsz-Him So, Feng-Ming Spring Kong.
J Thorac Dis, 2020 Jul 10; 12(6). PMID: 32642217    Free PMC article.
Prevalence of PD-L1 expression is associated with EMAST, density of peritumoral T-cells and recurrence-free survival in operable non-metastatic colorectal cancer.
Martin M Watson, Dordi Lea, +3 authors, Kjetil Søreide.
Cancer Immunol Immunother, 2020 Apr 22; 69(8). PMID: 32314040    Free PMC article.
Comprehensive review of targeted therapy for colorectal cancer.
Yuan-Hong Xie, Ying-Xuan Chen, Jing-Yuan Fang.
Signal Transduct Target Ther, 2020 Apr 17; 5(1). PMID: 32296018    Free PMC article.
Risk factors and predictors of lymph nodes metastasis and distant metastasis in newly diagnosed T1 colorectal cancer.
Kaibo Guo, Yuqian Feng, +4 authors, Shanming Ruan.
Cancer Med, 2020 May 30; 9(14). PMID: 32469151    Free PMC article.
Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge.
Ting Yang, Wei-Cong Chen, +7 authors, Jun Song.
J Exp Clin Cancer Res, 2020 Jul 22; 39(1). PMID: 32690100    Free PMC article.
Prognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis.
Meilian Dong, Yonggang Shi, +8 authors, Ruitai Fan.
Ther Adv Med Oncol, 2020 Jul 24; 12. PMID: 32699557    Free PMC article.
m6A methyltransferase METTL3 maintains colon cancer tumorigenicity by suppressing SOCS2 to promote cell proliferation.
Jihao Xu, Qikui Chen, +6 authors, Xianming Chen.
Oncol Rep, 2020 Jul 25; 44(3). PMID: 32705223    Free PMC article.
Clinical outcomes and prognostic factors of robotic assisted rectal cancer resection alone versus robotic rectal cancer resection with natural orifice extraction: a matched analysis.
Dongning Liu, Rui Luo, +6 authors, Taiyuan Li.
Sci Rep, 2020 Aug 01; 10(1). PMID: 32733103    Free PMC article.
Short- and long-term outcomes for transvaginal specimen extraction versus minilaparotomy after robotic anterior resection for colorectal cancer: a mono-institution retrospective study.
Gengmei Gao, Lan Chen, +2 authors, Taiyuan Li.
World J Surg Oncol, 2020 Jul 31; 18(1). PMID: 32727478    Free PMC article.
Cartilage Oligomeric Matrix Protein promotes epithelial-mesenchymal transition by interacting with Transgelin in Colorectal Cancer.
Weilong Zhong, Huiqin Hou, +13 authors, Bangmao Wang.
Theranostics, 2020 Aug 06; 10(19). PMID: 32754278    Free PMC article.
A novel prognostic signature of immune-related genes for patients with colorectal cancer.
Jun Wang, Shaojun Yu, +7 authors, Jian Chen.
J Cell Mol Med, 2020 Jun 22; 24(15). PMID: 32564470    Free PMC article.
Rat Bone Marrow-Derived Mesenchymal Stem Cells Promote the Migration and Invasion of Colorectal Cancer Stem Cells.
Weiyan Zou, Jie Zhao, +6 authors, Junbin Wang.
Onco Targets Ther, 2020 Aug 09; 13. PMID: 32764957    Free PMC article.
CD16 expression on neutrophils predicts treatment efficacy of capecitabine in colorectal cancer patients.
Yu Lu, Yizhou Huang, +7 authors, Yan Zhang.
BMC Immunol, 2020 Aug 11; 21(1). PMID: 32770940    Free PMC article.
CircRNAs in anticancer drug resistance: recent advances and future potential.
Tianwei Xu, Mengwei Wang, +5 authors, Zhaoxia Wang.
Mol Cancer, 2020 Aug 18; 19(1). PMID: 32799866    Free PMC article.
LncRNA H19 gene rs2839698 polymorphism is associated with a decreased risk of colorectal cancer in a Chinese Han population: A case-control study.
Bingqu Yu, Jiayuan Chen, +2 authors, Jie Jia.
J Clin Lab Anal, 2020 Mar 25; 34(8). PMID: 32207861    Free PMC article.
Gut Microbiota Manipulation as a Tool for Colorectal Cancer Management: Recent Advances in Its Use for Therapeutic Purposes.
Federica Perillo, Chiara Amoroso, +4 authors, Federica Facciotti.
Int J Mol Sci, 2020 Aug 06; 21(15). PMID: 32751239    Free PMC article.
Alteration of the abundance of Parvimonas micra in the gut along the adenoma-carcinoma sequence.
Jun Xu, Min Yang, +4 authors, Weichang Chen.
Oncol Lett, 2020 Aug 25; 20(4). PMID: 32831925    Free PMC article.
Study of Ras Mutations' Prognostic Value in Metastatic Colorectal Cancer: STORIA Analysis.
Alessandro Ottaiano, Nicola Normanno, +15 authors, Guglielmo Nasti.
Cancers (Basel), 2020 Jul 28; 12(7). PMID: 32708575    Free PMC article.
DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis.
Nazia Abbasi, Tianyun Long, +12 authors, Wendy Jia Men Huang.
Life Sci Alliance, 2020 Aug 21; 3(10). PMID: 32817263    Free PMC article.
Targeting NF-κB Signaling by Calebin A, a Compound of Turmeric, in Multicellular Tumor Microenvironment: Potential Role of Apoptosis Induction in CRC Cells.
Constanze Buhrmann, Parviz Shayan, +4 authors, Mehdi Shakibaei.
Biomedicines, 2020 Jul 28; 8(8). PMID: 32708030    Free PMC article.
The Role of Pro-Resolving Lipid Mediators in Colorectal Cancer-Associated Inflammation: Implications for Therapeutic Strategies.
Federica Ungaro, Silvia D'Alessio, Silvio Danese.
Cancers (Basel), 2020 Jul 30; 12(8). PMID: 32722560    Free PMC article.
Engineering the Bridge between Innate and Adaptive Immunity for Cancer Immunotherapy: Focus on γδ T and NK Cells.
Fabio Morandi, Mahboubeh Yazdanifar, +2 authors, Irma Airoldi.
Cells, 2020 Jul 28; 9(8). PMID: 32707982    Free PMC article.
MicroRNAs in Rectal Cancer: Functional Significance and Promising Therapeutic Value.
Laura Imedio, Ion Cristóbal, +3 authors, Jesús García-Foncillas.
Cancers (Basel), 2020 Jul 30; 12(8). PMID: 32722203    Free PMC article.
WAVE2 Enhanced Hepatic Stellate Cells Activity in Colorectal Liver Metastases.
Fengbo Tan, Dongren He, +5 authors, Yiming Tao.
Cancer Manag Res, 2020 Sep 10; 12. PMID: 32904432    Free PMC article.
Mitochondrial nanotargeting in malignancies (Review).
Anamaria Magdalena Tomşa, Andrei Picoş, Alina Monica Picoş, Andreea Liana Răchişan.
Exp Ther Med, 2020 Sep 10; 20(4). PMID: 32905128    Free PMC article.
Stabilization of oncogenic transcripts by the IGF2BP3/ELAVL1 complex promotes tumorigenicity in colorectal cancer.
Kexin Li, Furong Huang, +8 authors, Changzhi Huang.
Am J Cancer Res, 2020 Sep 10; 10(8). PMID: 32905413    Free PMC article.
Molecular Pathogenesis and Classification of Colorectal Carcinoma.
Anup Kasi, Shivani Handa, +3 authors, Weijing Sun.
Curr Colorectal Cancer Rep, 2020 Sep 10; 16(5). PMID: 32905465    Free PMC article.
Demethylzeylasteral inhibits cell proliferation and enhances cell chemosensitivity to 5-fluorouracil in Colorectal Cancer cells.
Yang Yang, Jing Han, +3 authors, Guiying Wang.
J Cancer, 2020 Sep 15; 11(20). PMID: 32922546    Free PMC article.
Systematic Review and Meta-Analysis of Multitargeted Tyrosine Kinase Inhibitors in Patients With Intractable Metastatic Colorectal Cancer.
Zhenzhen Gao, Chenxi Cao, +3 authors, Peng Fu.
Technol Cancer Res Treat, 2020 Sep 12; 19. PMID: 32914703    Free PMC article.
EZH2 regulates sFRP4 expression without affecting the methylation of sFRP4 promoter DNA in colorectal cancer cell lines.
Yuting Liu, Jun Yu, +4 authors, Jian Qi.
Exp Ther Med, 2020 Sep 22; 20(5). PMID: 32952624    Free PMC article.
Prognostic implications of metabolism-associated gene signatures in colorectal cancer.
Yandong Miao, Qiutian Li, +4 authors, Denghai Mi.
PeerJ, 2020 Sep 22; 8. PMID: 32953273    Free PMC article.
Development of Prognostic Indicator Based on Autophagy-Related lncRNA Analysis in Colon Adenocarcinoma.
Weige Zhou, Shijing Zhang, +6 authors, Xin-Lin Chen.
Biomed Res Int, 2020 Sep 24; 2020. PMID: 32964050    Free PMC article.
Association between Helicobacter pylori infection and the risk of colorectal cancer: A systematic review and meta-analysis.
Yuling Zuo, Zhao Jing, +3 authors, Baoning Wang.
Medicine (Baltimore), 2020 Sep 15; 99(37). PMID: 32925719    Free PMC article.
Systematic Review.
MicroRNA: Another Pharmacological Avenue for Colorectal Cancer?
Xueliang Wu, Fuguo Yan, +5 authors, Tian Li.
Front Cell Dev Biol, 2020 Sep 29; 8. PMID: 32984321    Free PMC article.
Favorable Outcomes in FGFR Fusion-Positive Cholangiocarcinomas and Evolution on Treatment Noted on Circulating Tumor DNA Liquid Biopsies.
Pashtoon Murtaza Kasi.
Case Rep Oncol, 2020 Oct 02; 13(2). PMID: 32999653    Free PMC article.
The interaction mechanism between autophagy and apoptosis in colon cancer.
Qingqiang Xie, Yuan Liu, Xuefeng Li.
Transl Oncol, 2020 Sep 21; 13(12). PMID: 32950931    Free PMC article.
MicroRNA-138-5p targets the NFIB-Snail1 axis to inhibit colorectal cancer cell migration and chemoresistance.
Weifeng Xu, Beibei Chen, Dianshan Ke, Xiaobing Chen.
Cancer Cell Int, 2020 Oct 06; 20. PMID: 33013202    Free PMC article.
Liquid Biopsy of Extracellular Vesicle-Derived miR-193a-5p in Colorectal Cancer and Discovery of Its Tumor-Suppressor Functions.
Rui Wei, Lei Chen, +5 authors, Shutian Zhang.
Front Oncol, 2020 Oct 06; 10. PMID: 33014778    Free PMC article.
Comprehensive Analysis of Prognostic Value and Immune Infiltration of Chromobox Family Members in Colorectal Cancer.
Qingshang Li, Yi Pan, Zhijun Cao, Shuliang Zhao.
Front Oncol, 2020 Oct 06; 10. PMID: 33014884    Free PMC article.
Proteomic Approach for Searching for Universal, Tissue-Specific, and Line-Specific Markers of Extracellular Vesicles in Lung and Colorectal Adenocarcinoma Cell Lines.
Svetlana Novikova, Natalia Shushkova, +3 authors, Victor Zgoda.
Int J Mol Sci, 2020 Sep 13; 21(18). PMID: 32916986    Free PMC article.
Downregulation of DUSP9 Promotes Tumor Progression and Contributes to Poor Prognosis in Human Colorectal Cancer.
Zhaoyan Qiu, Ning Liang, +5 authors, Qian Wang.
Front Oncol, 2020 Oct 20; 10. PMID: 33072575    Free PMC article.
Emerging roles for HMGA2 in colorectal cancer.
Xin Wang, Jian Wang, Jingjing Wu.
Transl Oncol, 2020 Oct 18; 14(1). PMID: 33069103    Free PMC article.
Downregulation of long non-coding RNA MAFG-AS1 represses tumorigenesis of colorectal cancer cells through the microRNA-149-3p-dependent inhibition of HOXB8.
Zhiyan Ruan, Hongling Deng, +5 authors, Xinguo Su.
Cancer Cell Int, 2020 Oct 24; 20. PMID: 33093810    Free PMC article.
Follow-Up 18F-FDG PET/CT versus Contrast-Enhanced CT after Ablation of Liver Metastases of Colorectal Carcinoma-A Cost-Effectiveness Analysis.
Moritz L Schnitzer, Matthias F Froelich, +6 authors, Johannes Rübenthaler.
Cancers (Basel), 2020 Sep 02; 12(9). PMID: 32867107    Free PMC article.
The Treatment of Heterotopic Human Colon Xenograft Tumors in Mice with 5-Fluorouracil Attached to Magnetic Nanoparticles in Combination with Magnetic Hyperthermia Is More Efficient than Either Therapy Alone.
Mohammad Dabaghi, Rainer Quaas, Ingrid Hilger.
Cancers (Basel), 2020 Sep 13; 12(9). PMID: 32916798    Free PMC article.
Diagnostic and Prognostic Significance of MiR-150 in Colorectal Cancer: A Systematic Review and Meta-Analysis.
Daniel Sur, Claudia Burz, Shanthi Sabarimurugan, Alexandru Irimie.
J Pers Med, 2020 Aug 28; 10(3). PMID: 32847098    Free PMC article.
Detection of genes responsible for cetuximab sensitization in colorectal cancer cells using CRISPR-Cas9.
Ting-Ting Hu, Jia-Wen Yang, +4 authors, Le-Chi Ye.
Biosci Rep, 2020 Oct 14; 40(10). PMID: 33048115    Free PMC article.
Resveratrol Suppresses Cross-Talk between Colorectal Cancer Cells and Stromal Cells in Multicellular Tumor Microenvironment: A Bridge between In Vitro and In Vivo Tumor Microenvironment Study.
Constanze Buhrmann, Parviz Shayan, Aranka Brockmueller, Mehdi Shakibaei.
Molecules, 2020 Sep 24; 25(18). PMID: 32962102    Free PMC article.
Comparison of safety between self-expanding metal stents as a bridge to surgery and emergency surgery based on pathology: a meta-analysis.
Yang Hu, Jiajun Fan, +4 authors, Qingsong Tao.
BMC Surg, 2020 Oct 29; 20(1). PMID: 33109142    Free PMC article.
Association of tricellulin expression with poor colorectal cancer prognosis and metastasis.
Jin-Xiu Zhang, Meng-Bin Qin, +8 authors, Jie-An Huang.
Oncol Rep, 2020 Oct 02; 44(5). PMID: 33000262    Free PMC article.
Analysis of microRNA-34a expression profile and rs2666433 variant in colorectal cancer: a pilot study.
Manal S Fawzy, Afaf T Ibrahiem, +2 authors, Eman A Toraih.
Sci Rep, 2020 Oct 11; 10(1). PMID: 33037254    Free PMC article.
Genetic Alterations of Metastatic Colorectal Cancer.
Ugo Testa, Germana Castelli, Elvira Pelosi.
Biomedicines, 2020 Oct 18; 8(10). PMID: 33066148    Free PMC article.
Effectiveness of underwater endoscopic mucosal resection versus conventional endoscopic mucosal resection for 10 to 20 mm colorectal polyps: A protocol of systematic review and meta-analysis.
Yi Liu, Min Shi, +2 authors, Song Liu.
Medicine (Baltimore), 2020 Nov 01; 99(44). PMID: 33126395    Free PMC article.
Systematic Review.
Diverse molecular functions of aspartate β‑hydroxylase in cancer (Review).
Wenqian Zheng, Xiaowei Wang, +2 authors, Hongbo Zhu.
Oncol Rep, 2020 Oct 31; 44(6). PMID: 33125119    Free PMC article.
Role of RASA1 in cancer: A review and update (Review).
Yanhua Zhang, Yue Li, +7 authors, Jun Cai.
Oncol Rep, 2020 Oct 31; 44(6). PMID: 33125148    Free PMC article.
Longitudinal analysis of healthy colon establishes aspirin as a suppressor of cancer-related epigenetic aging.
Faiza Noreen, Anna Chaber-Ciopinska, +2 authors, Kaspar Truninger.
Clin Epigenetics, 2020 Nov 05; 12(1). PMID: 33143725    Free PMC article.
ZBTB7A functioned as an oncogene in colorectal cancer.
Li Wang, Meng-Xia Zhang, Mei-Fang Zhang, Zi-Wei Tu.
BMC Gastroenterol, 2020 Nov 11; 20(1). PMID: 33167891    Free PMC article.
MicroRNA-802 Suppresses Tumorigenesis of Colorectal Cancer via Regulating UBN2.
Tao Yang, Qiuying Guo, +3 authors, Wei Wang.
Cancer Manag Res, 2020 Nov 13; 12. PMID: 33177873    Free PMC article.
Prognostic value of tumor infiltrating lymphocytes combined with PD-L1 expression for patients with solitary colorectal cancer liver metastasis.
Binyi Xiao, Jianhong Peng, +6 authors, Lin Zhang.
Ann Transl Med, 2020 Nov 13; 8(19). PMID: 33178753    Free PMC article.
Long Non-coding RNA LINC00115 Contributes to the Progression of Colorectal Cancer by Targeting miR-489-3p via the PI3K/AKT/mTOR Pathway.
Weiyu Feng, Baodong Li, +5 authors, Jing Zhuang.
Front Genet, 2020 Nov 17; 11. PMID: 33193658    Free PMC article.
Mechanisms of Core Chinese Herbs against Colorectal Cancer: A Study Based on Data Mining and Network Pharmacology.
Tong Lin, Caijun Liang, +2 authors, Lisheng Peng.
Evid Based Complement Alternat Med, 2020 Nov 17; 2020. PMID: 33193800    Free PMC article.
Neurensin-2 promotes proliferation, invasion and migration of colorectal cancer cells via interaction with SOX12.
Gang Wang, Kai Yang.
Oncol Lett, 2020 Nov 17; 20(6). PMID: 33193849    Free PMC article.
Integrated Analysis of Distant Metastasis-Associated Genes and Potential Drugs in Colon Adenocarcinoma.
Miaowei Wu, Weiyang Lou, +2 authors, Xiao-Fang Yu.
Front Oncol, 2020 Nov 17; 10. PMID: 33194689    Free PMC article.
Colorectal liver metastases: Current management and future perspectives.
Jack Martin, Angelica Petrillo, +12 authors, Emmanuel Huguet.
World J Clin Oncol, 2020 Nov 18; 11(10). PMID: 33200074    Free PMC article.
Identification prognosis-associated immune genes in colon adenocarcinoma.
Yandong Miao, Jiangtao Wang, +2 authors, Denghai Mi.
Biosci Rep, 2020 Nov 04; 40(11). PMID: 33140821    Free PMC article.
Endoscopic submucosal dissection in the treatment of patients with early colorectal carcinoma and precancerous lesions.
Jing Yu, Yan Zhang, Junbo Qian.
J Gastrointest Oncol, 2020 Nov 20; 11(5). PMID: 33209487    Free PMC article.
CASR rs1801725 polymorphism is associated with the risk and prognosis of colorectal cancer: A case-control study.
Yu-E Diao, Qing Xu.
J Clin Lab Anal, 2020 Jul 11; 34(11). PMID: 32648293    Free PMC article.
Bioinformatics Analysis Identifies a Novel Role of GINS1 Gene in Colorectal Cancer.
Fanqin Bu, Xiaojian Zhu, +5 authors, Jun Huang.
Cancer Manag Res, 2020 Nov 26; 12. PMID: 33235499    Free PMC article.
Ultra-Processed Food Intake and Smoking Interact in Relation with Colorectal Adenomas.
Naomi Fliss-Isakov, Shira Zelber-Sagi, +2 authors, Revital Kariv.
Nutrients, 2020 Nov 19; 12(11). PMID: 33202603    Free PMC article.
Revised Exon Structure of l-DOPA Decarboxylase (DDC) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression.
Pinelopi I Artemaki, Maria Papatsirou, +5 authors, Christos K Kontos.
Int J Mol Sci, 2020 Nov 19; 21(22). PMID: 33202911    Free PMC article.
Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and Opportunities.
Stephen P Hack, Andrew X Zhu, Yulei Wang.
Front Immunol, 2020 Dec 01; 11. PMID: 33250900    Free PMC article.
Antibiotic use and risk of colorectal cancer: a systematic review and dose-response meta-analysis.
Johanna Simin, Romina Fornes, +4 authors, Nele Brusselaers.
Br J Cancer, 2020 Sep 25; 123(12). PMID: 32968205    Free PMC article.
Systematic Review.
miR-20b-5p functions as tumor suppressor microRNA by targeting cyclinD1 in colon cancer.
Hui Yang, Jian Lin, +3 authors, Jun Zhang.
Cell Cycle, 2020 Oct 13; 19(21). PMID: 33044899    Free PMC article.
Prognostic Impact of the Neutrophil-to-Lymphocyte and Lymphocyte-to-Monocyte Ratio, in Patients with Rectal Cancer: A Retrospective Study of 1052 Patients.
Zsolt Zoltán Fülöp, Simona Gurzu, +4 authors, Ioan Jung.
J Pers Med, 2020 Oct 22; 10(4). PMID: 33081102    Free PMC article.
Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets.
Rong Li, Yu Li, +3 authors, Keng Po Lai.
Brief Bioinform, 2020 Nov 11; 22(2). PMID: 33169132    Free PMC article.
COPB2 gene silencing inhibits colorectal cancer cell proliferation and induces apoptosis via the JNK/c-Jun signaling pathway.
Yan Wang, Guangmei Xie, +2 authors, Min Wang.
PLoS One, 2020 Nov 20; 15(11). PMID: 33211699    Free PMC article.
Identification of Two Novel Circular RNAs Deriving from BCL2L12 and Investigation of Their Potential Value as a Molecular Signature in Colorectal Cancer.
Paraskevi Karousi, Pinelopi I Artemaki, +3 authors, Christos K Kontos.
Int J Mol Sci, 2020 Nov 27; 21(22). PMID: 33238574    Free PMC article.
The G-Protein Coupled Formyl Peptide Receptors and Their Role in the Progression of Digestive Tract Cancer.
Cuimeng Tian, Keqiang Chen, +3 authors, Ji Ming Wang.
Technol Cancer Res Treat, 2020 Dec 01; 19. PMID: 33251986    Free PMC article.
Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study.
Chu-Yi Huang, Yu-Jing Fang, +7 authors, Cai-Xia Zhang.
Nutrients, 2020 Dec 04; 12(11). PMID: 33266410    Free PMC article.
Dehydroxyhispolon Methyl Ether, A Hispolon Derivative, Inhibits WNT/β-Catenin Signaling to Elicit Human Colorectal Carcinoma Cell Apoptosis.
Hueng-Chuen Fan, Ya-Chu Hsieh, +6 authors, Chia-Che Chang.
Int J Mol Sci, 2020 Dec 04; 21(22). PMID: 33266494    Free PMC article.
LAD1 expression is associated with the metastatic potential of colorectal cancer cells.
Byul Moon, Suk-Jin Yang, +7 authors, Jung-Ae Kim.
BMC Cancer, 2020 Dec 04; 20(1). PMID: 33267790    Free PMC article.
Association of MDM4 Gene rs4245739 Polymorphism with the Risk and Clinical Characteristics of Colorectal Cancer in a Chinese Han Population.
De-Ming Zhao, Yu-E Diao, Qing Xu.
Pharmgenomics Pers Med, 2020 Dec 05; 13. PMID: 33273845    Free PMC article.
LINC00565 promotes the progression of colorectal cancer by upregulating EZH2.
Xiaxia Shao, Tao Zhao, +4 authors, Lichun Deng.
Oncol Lett, 2020 Dec 08; 21(1). PMID: 33281964    Free PMC article.
Hsa_circ_0004831 serves as a blood-based prognostic biomarker for colorectal cancer and its potentially circRNA-miRNA-mRNA regulatory network construction.
Linlin Xing, Mengyan Xia, Xin Jiao, Ling Fan.
Cancer Cell Int, 2020 Dec 10; 20(1). PMID: 33292256    Free PMC article.
Application of Carbon Nanoparticles in Tracing Lymph Nodes and Locating Tumors in Colorectal Cancer: A Concise Review.
Pengcheng Liu, Jie Tan, +3 authors, Qing Lv.
Int J Nanomedicine, 2020 Dec 10; 15. PMID: 33293812    Free PMC article.
No Coil® placement in patients undergoing left hemicolectomy and low anterior resection for colorectal cancer.
Michele Ammendola, Michele Ruggiero, +9 authors, Giuseppe Currò.
World J Surg Oncol, 2020 Dec 12; 18(1). PMID: 33302970    Free PMC article.
Yogurt consumption and colorectal cancer incidence and mortality in the Nurses' Health Study and the Health Professionals Follow-Up Study.
Karin B Michels, Walter C Willett, +2 authors, Edward Giovannucci.
Am J Clin Nutr, 2020 Oct 07; 112(6). PMID: 33022694    Free PMC article.
PD-L1 expression in liver metastasis: its clinical significance and discordance with primary tumor in colorectal cancer.
Xiao-Li Wei, Xuan Luo, +5 authors, Rui-Hua Xu.
J Transl Med, 2020 Dec 15; 18(1). PMID: 33308232    Free PMC article.
Interventional Treatment of Hepatic Metastases from Colorectal Cancer.
Patrick D Sutphin, Suvranu Ganguli.
Semin Intervent Radiol, 2020 Dec 18; 37(5). PMID: 33328705    Free PMC article.
Prognostic Model of Colorectal Cancer Constructed by Eight Immune-Related Genes.
Shuting Wen, Long He, +2 authors, Fengbin Liu.
Front Mol Biosci, 2020 Dec 18; 7. PMID: 33330631    Free PMC article.
SCTR hypermethylation is a diagnostic biomarker in colorectal cancer.
DaPeng Li, Lei Zhang, +7 authors, BinBin Cui.
Cancer Sci, 2020 Sep 25; 111(12). PMID: 32970347    Free PMC article.
Matrix metalloproteinase-8 rs11225395 polymorphism correlates with colorectal cancer risk and survival in a Chinese Han population: a case-control study.
Jiandong Tai, Di Sun, Xu Wang, Zhenhua Kang.
Aging (Albany NY), 2020 Oct 15; 12(19). PMID: 33052136    Free PMC article.
Metabolism-Associated Molecular Classification of Colorectal Cancer.
Meng Zhang, Hai-Zhou Wang, +3 authors, Qiu Zhao.
Front Oncol, 2020 Dec 22; 10. PMID: 33344254    Free PMC article.
Overexpression of gene DEP domain containing 1 and its clinical prognostic significance in colorectal cancer.
Xiaohan Shen, Jinming Han.
J Clin Lab Anal, 2020 Nov 04; 34(12). PMID: 33140894    Free PMC article.
Circ-PRKDC Facilitates the Progression of Colorectal Cancer Through miR-198/DDR1 Regulatory Axis.
Guixiang Wang, Yajun Li, +3 authors, Zhiyong Gao.
Cancer Manag Res, 2020 Dec 29; 12. PMID: 33364834    Free PMC article.
Integrating Tumor Stroma Biomarkers With Clinical Indicators for Colon Cancer Survival Stratification.
Yong Chen, Wenlong Wang, +3 authors, Xinying Li.
Front Med (Lausanne), 2020 Dec 29; 7. PMID: 33365318    Free PMC article.
The efficacy of Chinese herbal medicine as an adjunctive therapy for colorectal cancer: A protocol for systematic review of randomized controlled trials.
Wenyuan Li, Jing Guo, +2 authors, Fengming You.
Medicine (Baltimore), 2020 Dec 30; 99(51). PMID: 33371062    Free PMC article.
Systematic Review.
Resolving the Paradox of Colon Cancer Through the Integration of Genetics, Immunology, and the Microbiota.
Marine Fidelle, Satoru Yonekura, +4 authors, Laurence Zitvogel.
Front Immunol, 2021 Jan 01; 11. PMID: 33381121    Free PMC article.
An insight into small extracellular vesicles: Their roles in colorectal cancer progression and potential clinical applications.
Xuefeng He, Xinyang Zhong, +3 authors, Dawei Li.
Clin Transl Med, 2020 Dec 31; 10(8). PMID: 33377655    Free PMC article.
Circulating non-coding RNA cluster predicted the tumorigenesis and development of colorectal carcinoma.
Jie Li, Yifei Feng, +9 authors, Yueming Sun.
Aging (Albany NY), 2020 Nov 26; 12(22). PMID: 33234723    Free PMC article.
Role of gut microbiome in regulating the effectiveness of metformin in reducing colorectal cancer in type 2 diabetes.
Qi-You Huang, Fei Yao, +4 authors, Qing-Ming Wu.
World J Clin Cases, 2021 Jan 05; 8(24). PMID: 33392303    Free PMC article.
Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma.
Wei Jia, Cynthia Rajani, Hongxi Xu, Xiaojiao Zheng.
Protein Cell, 2020 Aug 17;. PMID: 32797354
Urachal carcinoma: Impact of recurrence pattern and lymphadenectomy on long-term outcomes.
Fangfang Duan, Wenyu Zhai, Bei Zhang, Shengjie Guo.
Cancer Med, 2020 Apr 25; 9(12). PMID: 32329250    Free PMC article.
CD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers.
Jerry B Harvey, Luan H Phan, Oscar E Villarreal, Jessica L Bowser.
Front Immunol, 2020 May 01; 11. PMID: 32351498    Free PMC article.
NK cell infiltration is associated with improved overall survival in solid cancers: A systematic review and meta-analysis.
Sarah Nersesian, Sarah L Schwartz, +4 authors, Jeanette E Boudreau.
Transl Oncol, 2020 Nov 14; 14(1). PMID: 33186888    Free PMC article.
Serrated neoplasia in the colorectum: gut microbiota and molecular pathways.
Xing Kang, Ru Zhang, +5 authors, Sunny H Wong.
Gut Microbes, 2021 Jan 01; 13(1). PMID: 33382354    Free PMC article.
Prognosis Prediction for Colorectal Cancer Patients: A Risk Score Based on The Metabolic-Related Genes.
Yongqu Lu, Xin Zhou, +3 authors, Wei Fu.
Int J Med Sci, 2021 Jan 14; 18(3). PMID: 33437216    Free PMC article.
CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer metastasis through transactivating CXCR4 and ITGB3.
Weibo Feng, Wenjie Huang, +12 authors, Limin Xia.
Theranostics, 2021 Jan 19; 11(6). PMID: 33456563    Free PMC article.
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting β-catenin degradation.
Chunqi Liu, Liang Wang, +16 authors, Yinglan Zhao.
Theranostics, 2021 Jan 19; 11(6). PMID: 33456583    Free PMC article.
Preparation of a novel EGFR specific immunotoxin and its efficacy of anti-colorectal cancer in vitro and in vivo.
Shuifa Wu, Cuimin Deng, +5 authors, Jieming Xie.
Clin Transl Oncol, 2021 Jan 22;. PMID: 33474678
Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer.
Yi-Qing Chen, Wen-Ting Zhu, +3 authors, Peng-Ke Yan.
Int J Nanomedicine, 2021 Jan 21; 16. PMID: 33469286    Free PMC article.
Prognostic Significance of Preoperative Lymphocyte-to-C-Reactive Protein Ratio in Patients with Non-Metastatic Colorectal Cancer.
Wenting Ou, Caijin Zhou, +2 authors, Qingwen Xu.
Onco Targets Ther, 2021 Jan 21; 14. PMID: 33469310    Free PMC article.
Aberrant SLC6A14 Expression Promotes Proliferation and Metastasis of Colorectal Cancer via Enhancing the JAK2/STAT3 Pathway.
Hongli Mao, Jinxiu Sheng, +4 authors, Fucheng He.
Onco Targets Ther, 2021 Jan 21; 14. PMID: 33469314    Free PMC article.
Gracillin shows potent efficacy against colorectal cancer through inhibiting the STAT3 pathway.
Lehe Yang, Tianru Zhu, +11 authors, Wanle Hu.
J Cell Mol Med, 2020 Dec 02; 25(2). PMID: 33259114    Free PMC article.
Fibroblast Subsets in Intestinal Homeostasis, Carcinogenesis, Tumor Progression, and Metastasis.
Hao Dang, Tom J Harryvan, Lukas J A C Hawinkels.
Cancers (Basel), 2021 Jan 13; 13(2). PMID: 33430285    Free PMC article.
Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy.
Xiaonan Zhang, Tobias Sjöblom.
Pharmaceuticals (Basel), 2021 Jan 17; 14(1). PMID: 33450833    Free PMC article.
Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer.
Xujun Song, Benno Traub, Jingwei Shi, Marko Kornmann.
Int J Mol Sci, 2021 Jan 17; 22(2). PMID: 33450900    Free PMC article.
Dysbiosis Triggers ACF Development in Genetically Predisposed Subjects.
Stefania De Santis, Marina Liso, +10 authors, Marcello Chieppa.
Cancers (Basel), 2021 Jan 21; 13(2). PMID: 33466665    Free PMC article.
Circ_0067835 Knockdown Enhances the Radiosensitivity of Colorectal Cancer by miR-296-5p/IGF1R Axis.
Peng Wang, Yongmin Sun, +2 authors, Hui Liu.
Onco Targets Ther, 2021 Jan 28; 14. PMID: 33500625    Free PMC article.
European expert consensus on a structured approach to training robotic-assisted low anterior resection using performance metrics.
S Tou, M Gómez Ruiz, +2 authors, ESCP ASPIRE collaborative.
Colorectal Dis, 2020 Jul 15;. PMID: 32663361    Free PMC article.
Mir-488 alleviates chemoresistance and glycolysis of colorectal cancer by targeting PFKFB3.
Xiaojing Deng, Dapeng Li, +5 authors, Hailun Zheng.
J Clin Lab Anal, 2020 Sep 30; 35(1). PMID: 32990355    Free PMC article.
Cyclodextrin-based host-guest complexes loaded with regorafenib for colorectal cancer treatment.
Hongzhen Bai, Jianwei Wang, +6 authors, Guping Tang.
Nat Commun, 2021 Feb 05; 12(1). PMID: 33536421    Free PMC article.
Comparison of irinotecan and oxaliplatin as the first-line therapies for metastatic colorectal cancer: a meta-analysis.
Sadayuki Kawai, Nozomi Takeshima, +6 authors, Hirofumi Yasui.
BMC Cancer, 2021 Feb 06; 21(1). PMID: 33541293    Free PMC article.
Targeting STAT proteins via computational analysis in colorectal cancer.
Begum Dariya, Santoshi Muppala, +3 authors, Madhu Sudhana Saddala.
Mol Cell Biochem, 2020 Aug 26; 476(1). PMID: 32840738
Identification of colorectal cancer-associated macrophage biomarkers by integrated bioinformatic analysis.
Dejun Cui, Wenqiang Yuan, Chen Chen, Ran Han.
Int J Clin Exp Pathol, 2021 Feb 04; 14(1). PMID: 33532018    Free PMC article.
Gut Microbial Signatures in Sporadic and Hereditary Colorectal Cancer.
Giorgia Mori, Maria Rosalia Pasca.
Int J Mol Sci, 2021 Feb 03; 22(3). PMID: 33525662    Free PMC article.
Pyrvinium pamoate inhibits cell proliferation through ROS-mediated AKT-dependent signaling pathway in colorectal cancer.
Wenqian Zheng, Jinhui Hu, +5 authors, Hongbo Zhu.
Med Oncol, 2021 Feb 09; 38(2). PMID: 33554313    Free PMC article.
Epidermal growth factor receptor intron 1 polymorphism and microsatellite instability in sporadic colorectal cancer.
Sonja Marinović, Kristina Vuković, +4 authors, Sanja Kapitanović.
Oncol Lett, 2021 Feb 09; 21(2). PMID: 33552252    Free PMC article.
P4HA1 regulates human colorectal cancer cells through HIF1α-mediated Wnt signaling.
Qiang Zhang, Yue Yin, +6 authors, Zhanjiang Yu.
Oncol Lett, 2021 Feb 09; 21(2). PMID: 33552264    Free PMC article.
A STING-related prognostic score predicts high-risk patients of colorectal cancer and provides insights into immunotherapy.
Si-Yuan Chen, Siyu Chen, +3 authors, Xiaodong Zhu.
Ann Transl Med, 2021 Feb 09; 9(1). PMID: 33553307    Free PMC article.
Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer.
Huifang Chen, Jiameng Yao, +9 authors, Hua-Bing Li.
Mol Cancer, 2021 Feb 10; 20(1). PMID: 33557837    Free PMC article.
Identification of four novel prognosis biomarkers and potential therapeutic drugs for human colorectal cancer by bioinformatics analysis.
Zhen Sun, Chen Liu, Steven Y Cheng.
J Biomed Res, 2020 Dec 29; 35(1). PMID: 33361643    Free PMC article.
A novel vaccinia virus enhances anti-tumor efficacy and promotes a long-term anti-tumor response in a murine model of colorectal cancer.
Na Wang, Jiwei Wang, +5 authors, Yaohe Wang.
Mol Ther Oncolytics, 2021 Feb 13; 20. PMID: 33575472    Free PMC article.
Single-Cell Analysis Reveals Characterization of Infiltrating T Cells in Moderately Differentiated Colorectal Cancer.
Xi Yang, Quan Qi, +6 authors, Shuwen Han.
Front Immunol, 2021 Feb 16; 11. PMID: 33584715    Free PMC article.
Clinical Perspectives on Liquid Biopsy in Metastatic Colorectal Cancer.
Wei Gao, Yigui Chen, +4 authors, Yi Shi.
Front Genet, 2021 Feb 16; 12. PMID: 33584829    Free PMC article.
Circ_0082182 promotes oncogenesis and metastasis of colorectal cancer in vitro and in vivo by sponging miR-411 and miR-1205 to activate the Wnt/β-catenin pathway.
Ruijie Liu, Ping Deng, +2 authors, Cuiping Peng.
World J Surg Oncol, 2021 Feb 19; 19(1). PMID: 33596920    Free PMC article.
Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer.
Yuchen Guo, Monica Gabola, +23 authors, Michael Hahne.
J Clin Invest, 2020 Dec 18; 131(4). PMID: 33332285    Free PMC article.
The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care.
Jeroen W G Derksen, Geraldine R Vink, +7 authors, PLCRC Study Group.
Sci Rep, 2021 Feb 18; 11(1). PMID: 33594104    Free PMC article.
Identification and validation of a miRNA-related expression signature for tumor mutational burden in colorectal cancer.
Lijun Xu, Qing Zheng.
World J Surg Oncol, 2021 Feb 22; 19(1). PMID: 33610190    Free PMC article.
Quxie Capsule Modulating Gut Microbiome and Its Association With T cell Regulation in Patients With Metastatic Colorectal Cancer: Result From a Randomized Controlled Clinical Trial.
Lingyun Sun, Yunzi Yan, Dongmei Chen, Yufei Yang.
Integr Cancer Ther, 2020 Nov 28; 19. PMID: 33243018    Free PMC article.
Activation of WNT7b autocrine eases metastasis of colorectal cancer via epithelial to mesenchymal transition and predicts poor prognosis.
Shuai Jiang, Qiwen Li, +15 authors, Peipei Zhang.
BMC Cancer, 2021 Feb 21; 21(1). PMID: 33607955    Free PMC article.
Targeting YTHDF1 effectively re-sensitizes cisplatin-resistant colon cancer cells by modulating GLS-mediated glutamine metabolism.
Ping Chen, Xi-Qiao Liu, +3 authors, Xuan Huang.
Mol Ther Oncolytics, 2021 Feb 23; 20. PMID: 33614908    Free PMC article.
Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer.
Yusuke Kobayashi, Kensuke Kumamoto, +14 authors, Koji Kono.
PLoS One, 2021 Feb 18; 16(2). PMID: 33596246    Free PMC article.
TUFT1 Facilitates Metastasis, Stemness, and Vincristine Resistance in Colorectal Cancer via Activation of PI3K/AKT Pathway.
Yang Yang, Tao Zhang, Lixiang Wu.
Biochem Genet, 2021 Feb 27;. PMID: 33634374
[Application of artificial intelligence for detection and classification of colon polyps].
X Wang, J Huang, X Ji, Z Zhu.
Nan Fang Yi Ke Da Xue Xue Bao, 2021 Feb 25; 41(2). PMID: 33624608    Free PMC article.
Dietary Rice Bran-Modified Human Gut Microbial Consortia Confers Protection against Colon Carcinogenesis Following Fecal Transfaunation.
Kristopher D Parker, Akhilendra K Maurya, +9 authors, Elizabeth P Ryan.
Biomedicines, 2021 Feb 07; 9(2). PMID: 33546192    Free PMC article.
Tumor Suppressor Protein p53 and Inhibitor of Apoptosis Proteins in Colorectal Cancer-A Promising Signaling Network for Therapeutic Interventions.
Ömer Güllülü, Stephanie Hehlgans, +2 authors, Franz Rödel.
Cancers (Basel), 2021 Feb 10; 13(4). PMID: 33557398    Free PMC article.
The Distinctive Serum Metabolomes of Gastric, Esophageal and Colorectal Cancers.
Zhenxing Ren, Cynthia Rajani, Wei Jia.
Cancers (Basel), 2021 Feb 14; 13(4). PMID: 33578739    Free PMC article.
Advances in Modeling the Immune Microenvironment of Colorectal Cancer.
Paul Sukwoo Yoon, Nuala Del Piccolo, +6 authors, Sepideh Gholami.
Front Immunol, 2021 Mar 02; 11. PMID: 33643296    Free PMC article.
Long intergenic non-coding RNA LINC00485 exerts tumor-suppressive activity by regulating miR-581/EDEM1 axis in colorectal cancer.
Chenmeng Li, Bei Pan, +9 authors, Shukui Wang.
Aging (Albany NY), 2021 Jan 19; 13(3). PMID: 33461166    Free PMC article.
Molecular features and gene expression signature of metastatic colorectal cancer (Review).
Martina Poturnajova, Tatiana Furielova, +3 authors, Miroslava Matuskova.
Oncol Rep, 2021 Mar 03; 45(4). PMID: 33649827    Free PMC article.
Aloperine Inhibits Proliferation and Promotes Apoptosis in Colorectal Cancer Cells by Regulating the circNSUN2/miR-296-5p/STAT3 Pathway.
Wei Han, Desong Kong, +2 authors, Zhimin Fan.
Drug Des Devel Ther, 2021 Mar 06; 15. PMID: 33664565    Free PMC article.
Ferroptosis-related genes are potential prognostic molecular markers for patients with colorectal cancer.
Yanliang Liu, Fengqin Guo, +3 authors, Tao Fu.
Clin Exp Med, 2021 Mar 07;. PMID: 33674956
LAT1 and ASCT2 Related microRNAs as Potential New Therapeutic Agents against Colorectal Cancer Progression.
Francisca Dias, Cristina Almeida, +2 authors, Rui Medeiros.
Biomedicines, 2021 Mar 07; 9(2). PMID: 33669301    Free PMC article.
Identification and Characterization of MortaparibPlus-A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms.
Anissa Nofita Sari, Ahmed Elwakeel, +4 authors, Renu Wadhwa.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33671256    Free PMC article.
Impact of Preoperative Total Proteins and Glycated Hemoglobin on Recurrences after Early Colorectal Cancer.
María-José Castro, José-María Jiménez, +5 authors, Jaime Ruiz-Tovar.
Nutrients, 2021 Mar 07; 13(2). PMID: 33672318    Free PMC article.
Identification and Validation of a Novel Six-Gene Prognostic Signature of Stem Cell Characteristic in Colon Cancer.
Yichao Liang, Qi Su, Xin Wu.
Front Oncol, 2021 Mar 09; 10. PMID: 33680915    Free PMC article.
Circ_DOCK1 regulates USP11 through miR-132-3p to control colorectal cancer progression.
Weitong Zhang, Zhenfen Wang, Guohao Cai, Ping Huang.
World J Surg Oncol, 2021 Mar 10; 19(1). PMID: 33685455    Free PMC article.
REG4 is a Potential Biomarker for Radiochemotherapy Sensitivity in Colorectal Cancer.
Lei Gao, Xingjun Wu, +4 authors, Kaijing Wang.
Onco Targets Ther, 2021 Mar 11; 14. PMID: 33688207    Free PMC article.
Establishment and Characterization of an Irinotecan-Resistant Human Colon Cancer Cell Line.
Zhuo-Xun Wu, Yuqi Yang, +4 authors, Zhe-Sheng Chen.
Front Oncol, 2021 Mar 12; 10. PMID: 33692943    Free PMC article.
The clinical features, management, and survival of elderly patients with colorectal cancer.
Lei Shen, Ke Meng, +3 authors, Xiaomei Zhang.
J Gastrointest Oncol, 2021 Mar 13; 12(1). PMID: 33708427    Free PMC article.
Cullin-5 neddylation-mediated NOXA degradation is enhanced by PRDX1 oligomers in colorectal cancer.
Shoufang Xu, Yilei Ma, +9 authors, Jun Zhang.
Cell Death Dis, 2021 Mar 14; 12(3). PMID: 33712558    Free PMC article.
Signaling pathways in intestinal homeostasis and colorectal cancer: KRAS at centre stage.
Camille Ternet, Christina Kiel.
Cell Commun Signal, 2021 Mar 12; 19(1). PMID: 33691728    Free PMC article.
Kinase GSK3β functions as a suppressor in colorectal carcinoma through the FTO-mediated MZF1/c-Myc axis.
Zeyan Zhang, Qianfu Gao, Shanchao Wang.
J Cell Mol Med, 2021 Feb 04; 25(5). PMID: 33533172    Free PMC article.
Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo.
Tiago De Oliveira, Tina Goldhardt, +16 authors, Lena-Christin Conradi.
Cancers (Basel), 2021 Mar 07; 13(5). PMID: 33671096    Free PMC article.
MicroRNA-432-5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer.
Man Luo, Zuowei Hu, Yuefeng Kong, Lingyi Li.
Exp Ther Med, 2021 Mar 16; 21(4). PMID: 33717244    Free PMC article.
A National Study of Colorectal Cancer Survivorship Disparities: A Latent Class Analysis Using SEER (Surveillance, Epidemiology, and End Results) Registries.
Francisco A Montiel Ishino, Emmanuel A Odame, +4 authors, Faustine Williams.
Front Public Health, 2021 Mar 16; 9. PMID: 33718323    Free PMC article.
CDC42EP3 promotes colorectal cancer through regulating cell proliferation, cell apoptosis and cell migration.
Qiang Feng, Dongkui Xu, +5 authors, Wei Pei.
Cancer Cell Int, 2021 Mar 18; 21(1). PMID: 33726765    Free PMC article.
Circ_0005927 Inhibits the Progression of Colorectal Cancer by Regulating miR-942-5p/BATF2 Axis.
Chao Yu, Deguan Li, +5 authors, Zhen Zhang.
Cancer Manag Res, 2021 Mar 19; 13. PMID: 33732022    Free PMC article.
Exosomal miR-590-3p derived from cancer-associated fibroblasts confers radioresistance in colorectal cancer.
Xijuan Chen, Yingqiang Liu, +5 authors, Junqi Liu.
Mol Ther Nucleic Acids, 2021 Mar 20; 24. PMID: 33738143    Free PMC article.
A Prognostic Nomogram of Colon Cancer With Liver Metastasis: A Study of the US SEER Database and a Chinese Cohort.
Chuan Liu, Chuan Hu, +9 authors, Ti Wen.
Front Oncol, 2021 Mar 20; 11. PMID: 33738248    Free PMC article.
Characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy.
Chengsheng Ding, Zezhi Shan, +3 authors, Zhiming Jin.
Mol Ther Oncolytics, 2021 Mar 20; 20. PMID: 33738339    Free PMC article.
Circ_0003266 sponges miR-503-5p to suppress colorectal cancer progression via regulating PDCD4 expression.
Caihong Wen, Xiaoqing Feng, +2 authors, Guangsheng Wang.
BMC Cancer, 2021 Mar 18; 21(1). PMID: 33726686    Free PMC article.
Identification of Five Glycolysis-Related Gene Signature and Risk Score Model for Colorectal Cancer.
Jun Zhu, Shuai Wang, +4 authors, Jipeng Li.
Front Oncol, 2021 Mar 23; 11. PMID: 33747908    Free PMC article.
Comprehensive analysis of ceRNA networks reveals prognostic lncRNAs related to immune infiltration in colorectal cancer.
Jingyi Chen, Yuxuan Song, +7 authors, Weidong Yu.
BMC Cancer, 2021 Mar 23; 21(1). PMID: 33750326    Free PMC article.
Mucosa-associated cultivable aerobic gut bacterial microbiota among colorectal cancer patients attending at the referral hospitals of Amhara Regional State, Ethiopia.
Yesuf Adem Siraj, Melesse Gebeyehu Biadgelign, Mensur Osman Yassin, Yohannes Zenebe Chekol.
Gut Pathog, 2021 Mar 24; 13(1). PMID: 33752753    Free PMC article.
Circ_ 0115744 acts as miR-144 sponge to promote and predict the metastasis of colorectal cancer.
Xiaoming Ma, Long Lv, Chungen Xing.
Aging (Albany NY), 2021 Feb 17; 13(4). PMID: 33591945    Free PMC article.
N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization.
Chen Chen, Weitang Yuan, +13 authors, Zhenqiang Sun.
Theranostics, 2021 Mar 24; 11(9). PMID: 33754062    Free PMC article.
Association of chemotherapy with survival in stage II colon cancer patients who received radical surgery: a retrospective cohort study.
Zhihao Lv, Yuqi Liang, Huaxi Liu, Delong Mo.
BMC Cancer, 2021 Mar 25; 21(1). PMID: 33757442    Free PMC article.
Rising incidence of early-onset colorectal cancer - a call to action.
Naohiko Akimoto, Tomotaka Ugai, +7 authors, Shuji Ogino.
Nat Rev Clin Oncol, 2020 Nov 22; 18(4). PMID: 33219329    Free PMC article.
Propensity score-matched comparison of stenting as a bridge to surgery and emergency surgery for acute malignant left-sided colonic obstruction.
Yuepeng Cao, Qing Chen, +6 authors, Qi Huang.
BMC Surg, 2021 Mar 22; 21(1). PMID: 33743658    Free PMC article.
USP11 induce resistance to 5-Fluorouracil in Colorectal Cancer through activating autophagy by stabilizing VCP.
Hongze Sun, Rangrang Wang, +3 authors, Zhihai Peng.
J Cancer, 2021 Mar 25; 12(8). PMID: 33758608    Free PMC article.
Short-Term and Long-Term Outcomes in Mid and Low Rectal Cancer With Robotic Surgery.
Jingwen Chen, Zhiyuan Zhang, +5 authors, Ye Wei.
Front Oncol, 2021 Mar 27; 11. PMID: 33767981    Free PMC article.
RGD4C peptide mediates anti-p21Ras scFv entry into tumor cells and produces an inhibitory effect on the human colon cancer cell line SW480.
Chen-Chen Huang, Fang-Rui Liu, +3 authors, Ju-Lun Yang.
BMC Cancer, 2021 Mar 27; 21(1). PMID: 33765976    Free PMC article.
Pyroptosis: mechanisms and diseases.
Pian Yu, Xu Zhang, +3 authors, Xiang Chen.
Signal Transduct Target Ther, 2021 Mar 30; 6(1). PMID: 33776057    Free PMC article.
Flipside of the Coin: Iron Deficiency and Colorectal Cancer.
Aysegül Aksan, Karima Farrag, +2 authors, Jürgen Stein.
Front Immunol, 2021 Mar 30; 12. PMID: 33777027    Free PMC article.
The Effects of Autophagy-Related Genes and lncRNAs in Therapy and Prognosis of Colorectal Cancer.
Yang Yang, Mingyang Feng, +7 authors, Qiu Li.
Front Oncol, 2021 Mar 30; 11. PMID: 33777735    Free PMC article.
Downregulation of Circ_0071589 Suppresses Cisplatin Resistance in Colorectal Cancer by Regulating the MiR-526b-3p/KLF12 Axis.
Weitong Zhang, Zhenfen Wang, Guohao Cai, Ping Huang.
Cancer Manag Res, 2021 Apr 02; 13. PMID: 33790646    Free PMC article.
Loss of BRMS2 induces cell growth inhibition and translation capacity reduction in colorectal cancer cells.
Yaofu Liu, Weimin Xu, +5 authors, Yili Yang.
Am J Cancer Res, 2021 Apr 02; 11(3). PMID: 33791164    Free PMC article.
Utidelone inhibits growth of colorectal cancer cells through ROS/JNK signaling pathway.
Fuli Li, Tinglei Huang, +7 authors, Shuiping Tu.
Cell Death Dis, 2021 Apr 03; 12(4). PMID: 33795638    Free PMC article.
Conflicting Guidelines: A Systematic Review on the Proper Interval for Colorectal Cancer Treatment.
Charlotte J L Molenaar, Loes Janssen, +3 authors, Gerrit D Slooter.
World J Surg, 2021 Apr 05;. PMID: 33813632
Clinical Utility of a Cell-Free DNA Assay in Patients With Colorectal Cancer.
Ren-Hao Chan, Peng-Chan Lin, +5 authors, Yu-Min Yeh.
Front Oncol, 2021 Apr 06; 11. PMID: 33816227    Free PMC article.
Microbial Metabolites in Colorectal Cancer: Basic and Clinical Implications.
Yao Peng, Yuqiang Nie, Jun Yu, Chi Chun Wong.
Metabolites, 2021 Apr 04; 11(3). PMID: 33802045    Free PMC article.
Proteomic Analyses of Fibroblast- and Serum-Derived Exosomes Identify QSOX1 as a Marker for Non-invasive Detection of Colorectal Cancer.
Nicole Ganig, Franziska Baenke, +12 authors, Christoph Kahlert.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33802764    Free PMC article.
Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology.
Loretta László, Anita Kurilla, +4 authors, Virag Vas.
Cells, 2021 Apr 04; 10(3). PMID: 33802849    Free PMC article.
Emerging Trends for Radio-Immunotherapy in Rectal Cancer.
Claudia Corrò, Valérie Dutoit, Thibaud Koessler.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33803620    Free PMC article.
The Role of Cancer Stem Cells in Colorectal Cancer: From the Basics to Novel Clinical Trials.
Céline Hervieu, Niki Christou, Serge Battu, Muriel Mathonnet.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33806312    Free PMC article.
Baseline and Kinetic Circulating Tumor Cell Counts Are Prognostic Factors in a Prospective Study of Metastatic Colorectal Cancer.
Virgílio Souza E Silva, Emne Ali Abdallah, +6 authors, Ludmilla Thomé Domingos Chinen.
Diagnostics (Basel), 2021 Apr 04; 11(3). PMID: 33809053    Free PMC article.
Future Prospects of Colorectal Cancer Screening: Characterizing Interval Cancers.
Gemma Ibáñez-Sanz, Rebeca Sanz-Pamplona, Montse Garcia, On Behalf Of The Msic-Sc Research Group.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33809520    Free PMC article.
Infiltrative Tumor Borders in Colorectal Liver Metastasis: Should We Enlarge Margin Size?
Vitoria Ramos Jayme, Gilton Marques Fonseca, +6 authors, Paulo Herman.
Ann Surg Oncol, 2021 Apr 10;. PMID: 33834322
Impaired AGO2/miR-185-3p/NRP1 axis promotes colorectal cancer metastasis.
Xisheng Liu, Xiaole Meng, +10 authors, Zhihai Peng.
Cell Death Dis, 2021 Apr 14; 12(4). PMID: 33846300
Psychological distance: a qualitative study of screening barriers among first-degree relatives of colorectal cancer patients.
Xueying Zhang, Yiheng Zhang, +2 authors, Ni Gong.
BMC Public Health, 2021 Apr 15; 21(1). PMID: 33849506    Free PMC article.
PRMT5 promotes colorectal cancer growth by interaction with MCM7.
Xiangwei Li, Xin Wang, +2 authors, Jingjing Wu.
J Cell Mol Med, 2021 Mar 07; 25(7). PMID: 33675123    Free PMC article.
LncRNA ACTA2-AS1 suppress colon adenocarcinoma progression by sponging miR-4428 upregulation BCL2L11.
Qingyun Pan, Ying Huang, +2 authors, Changjiang Lei.
Cancer Cell Int, 2021 Apr 14; 21(1). PMID: 33845844    Free PMC article.
Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway.
Xiaofeng Liu, Kunqi Su, +7 authors, Baocai Xing.
J Exp Clin Cancer Res, 2021 Apr 17; 40(1). PMID: 33858476    Free PMC article.
Efficacy and safety of chronomodulated irinotecan, oxaliplatin, 5-fluorouracil and leucovorin combination as first- or second-line treatment against metastatic colorectal cancer: Results from the International EORTC 05011 Trial.
Pasquale F Innominato, Abdoulaye Karaboué, +8 authors, Carlo Garufi.
Int J Cancer, 2020 Dec 04;. PMID: 33270911    Free PMC article.
Diagnostic performance of a faecal immunochemical test for patients with low-risk symptoms of colorectal cancer in primary care: an evaluation in the South West of England.
Sarah E R Bailey, Gary A Abel, +11 authors, Willie Hamilton.
Br J Cancer, 2021 Jan 20; 124(7). PMID: 33462361    Free PMC article.
Perioperative risk factors for survival outcomes in elective colorectal cancer surgery: a retrospective cohort study.
Xing-Xing Liu, Jun Su, +2 authors, Zhao-Qiong Zhu.
BMC Gastroenterol, 2021 Apr 15; 21(1). PMID: 33849450    Free PMC article.
Characteristics of the gut microbiome profile in obese patients with colorectal cancer.
Masakuni Shoji, Yu Sasaki, +14 authors, Yoshiyuki Ueno.
JGH Open, 2021 Apr 17; 5(4). PMID: 33860101    Free PMC article.
Repositioning metformin and propranolol for colorectal and triple negative breast cancers treatment.
L E Anselmino, M V Baglioni, +8 authors, M Menacho Márquez.
Sci Rep, 2021 Apr 16; 11(1). PMID: 33854147    Free PMC article.
Distinguishing Rectal Cancer from Colon Cancer Based on the Support Vector Machine Method and RNA-sequencing Data.
Yan Zhang, Yuan Wu, +12 authors, Bo Shen.
Curr Med Sci, 2021 Apr 21; 41(2). PMID: 33877555
Progesterone suppresses the progression of colonic carcinoma by increasing the activity of the GADD45α/JNK/c‑Jun signalling pathway.
Yao-Lei Zhang, Xu-Dong Wen, +6 authors, Yong-He Hu.
Oncol Rep, 2021 Apr 14; 45(6). PMID: 33846816    Free PMC article.
Construction and validation of an RNA-binding protein-associated prognostic model for colorectal cancer.
Yandong Miao, Hongling Zhang, +4 authors, Denghai Mi.
PeerJ, 2021 Apr 20; 9. PMID: 33868829    Free PMC article.
Propofol postpones colorectal cancer development through circ_0026344/miR-645/Akt/mTOR signal pathway.
Xiaomin Cui, Jiying Feng, +2 authors, Mengyao Ding.
Open Med (Wars), 2021 Apr 20; 16(1). PMID: 33869779    Free PMC article.
Taraxasterol acetate targets RNF31 to inhibit RNF31/p53 axis-driven cell proliferation in colorectal cancer.
Chao-Tao Tang, Jing Yang, +2 authors, Chunyan Zeng.
Cell Death Discov, 2021 Apr 08; 7(1). PMID: 33824292    Free PMC article.
DNA hypermethylation contributes to colorectal cancer metastasis by regulating the binding of CEBPB and TFCP2 to the CPEB1 promoter.
Keke Shao, Weilin Pu, +8 authors, Weifeng Ding.
Clin Epigenetics, 2021 Apr 25; 13(1). PMID: 33892791    Free PMC article.
Combining the Fecal Immunochemical Test with a Logistic Regression Model for Screening Colorectal Neoplasia.
Feiyuan Liu, Qiaoyun Long, +4 authors, Weiqing Wu.
Front Pharmacol, 2021 Apr 27; 12. PMID: 33897424    Free PMC article.
Participation of Short-Chain Fatty Acids and Their Receptors in Gut Inflammation and Colon Cancer.
María Daniella Carretta, John Quiroga, +2 authors, Rafael Agustín Burgos.
Front Physiol, 2021 Apr 27; 12. PMID: 33897470    Free PMC article.