Review
. 2019 Nov; 11(11):1683.
doi: 10.3390/cancers11111683.

Role of Focal Adhesion Kinase in Small-Cell Lung Cancer and Its Potential as a Therapeutic Target

Frank Aboubakar Nana 1 Marie Vanderputten 2 Sebahat Ocak 3 
Affiliations
  • PMID: 31671774
  •     272 References
  •     8 citations

Abstract

Small-cell lung cancer (SCLC) represents 15% of all lung cancers and it is clinically the most aggressive type, being characterized by a tendency for early metastasis, with two-thirds of the patients diagnosed with an extensive stage (ES) disease and a five-year overall survival (OS) as low as 5%. There are still no effective targeted therapies in SCLC despite improved understanding of the molecular steps leading to SCLC development and progression these last years. After four decades, the only modest improvement in OS of patients suffering from ES-SCLC has recently been shown in a trial combining atezolizumab, an anti-PD-L1 immune checkpoint inhibitor, with carboplatin and etoposide, chemotherapy agents. This highlights the need to pursue research efforts in this field. Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase that is overexpressed and activated in several cancers, including SCLC, and contributing to cancer progression and metastasis through its important role in cell proliferation, survival, adhesion, spreading, migration, and invasion. FAK also plays a role in tumor immune evasion, epithelial-mesenchymal transition, DNA damage repair, radioresistance, and regulation of cancer stem cells. FAK is of particular interest in SCLC, being known for its aggressiveness. The inhibition of FAK in SCLC cell lines demonstrated significative decrease in cell proliferation, invasion, and migration, and induced cell cycle arrest and apoptosis. In this review, we will focus on the role of FAK in cancer cells and their microenvironment, and its potential as a therapeutic target in SCLC.

Keywords: focal adhesion kinase; small-cell lung cancer; targeted therapy.

Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Shi-Quan Liu, Chun-Yan Xu, +4 authors, Jie-An Huang.
Int J Oncol, 2018 Oct 27; 54(1). PMID: 30365116    Free PMC article.
Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant KRAS Lung Cancer.
Ke-Jing Tang, Jerfiz D Constanzo, +7 authors, Pier Paolo Scaglioni.
Clin Cancer Res, 2016 May 26; 22(23). PMID: 27220963    Free PMC article.
High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype.
Vita M Golubovskaya, Lourdes Ylagan, +8 authors, William G Cance.
BMC Cancer, 2014 Oct 20; 14. PMID: 25326692    Free PMC article.
The signaling and biological implications of FAK overexpression in cancer.
Priscila M F Siesser, Steven K Hanks.
Clin Cancer Res, 2006 Jun 03; 12(11 Pt 1). PMID: 16740741
Review.
Molecular profiling of ALDH1+ colorectal cancer stem cells reveals preferential activation of MAPK, FAK, and oxidative stress pro-survival signalling pathways.
Radhakrishnan Vishnubalaji, Muthurangan Manikandan, +5 authors, Nehad M Alajez.
Oncotarget, 2018 Mar 24; 9(17). PMID: 29568377    Free PMC article.
Fibroblast Growth Factor Receptor 1 and Related Ligands in Small-Cell Lung Cancer.
Liping Zhang, Hui Yu, +12 authors, Fred R Hirsch.
J Thorac Oncol, 2015 May 29; 10(7). PMID: 26020126    Free PMC article.
Increased Expression and Activation of FAK in Small-Cell Lung Cancer Compared to Non-Small-Cell Lung Cancer.
Frank Aboubakar Nana, Delphine Hoton, +7 authors, Sebahat Ocak.
Cancers (Basel), 2019 Oct 30; 11(10). PMID: 31658694    Free PMC article.
Overexpression and significance of focal adhesion kinase in hepatocellular carcinoma and its relationship with HBV infection.
Lei Cai, Juan Han, +3 authors, Xiaowu Li.
Med Oncol, 2008 Nov 21; 26(4). PMID: 19021002
Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271.
Walter Gregory Roberts, Ethan Ung, +21 authors, Felix Vajdos.
Cancer Res, 2008 Mar 15; 68(6). PMID: 18339875
Highly Cited.
Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial.
Corinne Faivre-Finn, Michael Snee, +18 authors, CONVERT Study Team.
Lancet Oncol, 2017 Jun 24; 18(8). PMID: 28642008    Free PMC article.
Highly Cited.
Focal adhesion kinase: in command and control of cell motility.
Satyajit K Mitra, Daniel A Hanson, David D Schlaepfer.
Nat Rev Mol Cell Biol, 2005 Feb 03; 6(1). PMID: 15688067
Highly Cited. Review.
3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226.
Stephanie Hehlgans, Inga Lange, Iris Eke, Nils Cordes.
Radiother Oncol, 2009 Sep 05; 92(3). PMID: 19729215
The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells.
E Batlle, E Sancho, +4 authors, A García De Herreros.
Nat Cell Biol, 2000 Feb 03; 2(2). PMID: 10655587
Highly Cited.
Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration.
D C Han, T L Shen, J L Guan.
J Biol Chem, 2000 Jul 14; 275(37). PMID: 10893408
Vascular permeability and drug delivery in cancers.
Sandy Azzi, Jagoda K Hebda, Julie Gavard.
Front Oncol, 2013 Aug 24; 3. PMID: 23967403    Free PMC article.
Highly Cited.
Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn.
L A Cary, J F Chang, J L Guan.
J Cell Sci, 1996 Jul 01; 109 ( Pt 7). PMID: 8832401
Highly Cited.
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase.
D D Schlaepfer, S K Hanks, T Hunter, P van der Geer.
Nature, 1994 Dec 22; 372(6508). PMID: 7997267
Highly Cited.
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Lauren Averett Byers, Jing Wang, +25 authors, John V Heymach.
Cancer Discov, 2012 Sep 11; 2(9). PMID: 22961666    Free PMC article.
Highly Cited.
Role of tyrosine specific phosphorylation of cellular proteins, especially EGF receptor and p125FAK in human lung cancer cells.
M Imaizumi, M Nishimura, +2 authors, M Hamaguchi.
Lung Cancer, 1997 May 01; 17(1). PMID: 9194028
Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer.
Frank Aboubakar Nana, Marylène Lecocq, +7 authors, Sebahat Ocak.
Mol Cancer Ther, 2018 Oct 26; 18(1). PMID: 30352800    Free PMC article.
Expression of focal adhesion kinase in small-cell lung carcinoma.
Sebahat Ocak, Heidi Chen, +2 authors, Pierre P Massion.
Cancer, 2011 Jul 30; 118(5). PMID: 21800286    Free PMC article.
SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells.
Chun-Yan Xu, Shi-Quan Liu, +5 authors, Jie-An Huang.
Int J Mol Med, 2017 Apr 14; 39(5). PMID: 28405684
Pembrolizumab in Patients With Extensive-Stage Small-Cell Lung Cancer: Results From the Phase Ib KEYNOTE-028 Study.
Patrick A Ott, Elena Elez, +5 authors, Janice M Mehnert.
J Clin Oncol, 2017 Aug 17; 35(34). PMID: 28813164
Highly Cited.
STK899704 inhibits stemness of cancer stem cells and migration via the FAK-MEK-ERK pathway in HT29 cells.
Hui-Ju Jang, Yesol Bak, +4 authors, Do-Young Yoon.
BMB Rep, 2018 Oct 03; 51(11). PMID: 30269740    Free PMC article.
Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma.
Jerry E Stewart, Xiaojie Ma, +4 authors, Elizabeth A Beierle.
Mol Carcinog, 2013 Jul 23; 54(1). PMID: 23868727    Free PMC article.
Clinicopathological significance of cancer stem-like cell markers in high-grade neuroendocrine carcinoma of the lung.
Masahiro Morise, Tomoyuki Hishida, +4 authors, Genichiro Ishii.
J Cancer Res Clin Oncol, 2015 May 13; 141(12). PMID: 25963795
Real-world effectiveness and tolerability of small-cell lung cancer (SCLC) treatments: A systematic literature review (SLR).
Manca Povsic, Ashley Enstone, +3 authors, Yong Yuan.
PLoS One, 2019 Jul 19; 14(7). PMID: 31318909    Free PMC article.
Systematic Review.
Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in squamous cell carcinoma of the larynx.
Michael S Aronsohn, Heather M Brown, Garrett Hauptman, Lori J Kornberg.
Laryngoscope, 2003 Nov 07; 113(11). PMID: 14603053
Inhibition of FAK kinase activity preferentially targets cancer stem cells.
Vihren N Kolev, Winnie F Tam, +7 authors, David T Weaver.
Oncotarget, 2017 Sep 09; 8(31). PMID: 28881682    Free PMC article.
Antiproliferative effects of EGFR tyrosine kinase inhibition and radiation-induced genotoxic injury are attenuated by adhesion to fibronectin.
Iris Eke, Veit Sandfort, +2 authors, Nils Cordes.
Radiother Oncol, 2006 Aug 08; 80(2). PMID: 16891020
High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome.
Klaus Jürgen Schmitz, Florian Grabellus, +6 authors, Hideo Andreas Baba.
Breast Cancer Res, 2005 Mar 04; 7(2). PMID: 15743500    Free PMC article.
Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.
Ming Luo, Huaping Fan, +5 authors, Jun-Lin Guan.
Cancer Res, 2009 Jan 17; 69(2). PMID: 19147559    Free PMC article.
Highly Cited.
Elevated expression of SOX2 and FGFR1 in correlation with poor prognosis in patients with small cell lung cancer.
Fang Yang, Yina Gao, +4 authors, Gongyan Chen.
Int J Clin Exp Pathol, 2013 Dec 03; 6(12). PMID: 24294370    Free PMC article.
Proteomic Profiling Identifies PTK2/FAK as a Driver of Radioresistance in HPV-negative Head and Neck Cancer.
Heath D Skinner, Uma Giri, +15 authors, John V Heymach.
Clin Cancer Res, 2016 Apr 03; 22(18). PMID: 27036135    Free PMC article.
Bombesin, vasopressin, lysophosphatidic acid, and sphingosylphosphorylcholine induce focal adhesion kinase activation in intact Swiss 3T3 cells.
J L Rodríguez-Fernández, E Rozengurt.
J Biol Chem, 1998 Jul 21; 273(30). PMID: 9668122
Atezolizumab plus bevacizumab and chemotherapy in non-small-cell lung cancer (IMpower150): key subgroup analyses of patients with EGFR mutations or baseline liver metastases in a randomised, open-label phase 3 trial.
Martin Reck, Tony S K Mok, +18 authors, IMpower150 Study Group.
Lancet Respir Med, 2019 Mar 30; 7(5). PMID: 30922878
Highly Cited.
Survival in small cell lung cancer is independent of tumor expression of VEGF and COX-2.
Jonathan E Dowell, Robin H Amirkhan, +2 authors, John D Minna.
Anticancer Res, 2004 Aug 28; 24(4). PMID: 15330186
Italian, Multicenter, Phase III, Randomized Study of Cisplatin Plus Etoposide With or Without Bevacizumab as First-Line Treatment in Extensive-Disease Small-Cell Lung Cancer: The GOIRC-AIFA FARM6PMFJM Trial.
Marcello Tiseo, Luca Boni, +16 authors, Andrea Ardizzoni.
J Clin Oncol, 2017 Jan 31; 35(12). PMID: 28135143
Highly Cited.
Overexpression of focal adhesion kinase correlates with increased lymph node metastasis and poor prognosis in non-small-cell lung cancer.
Hong-Fei Ji, Da Pang, +4 authors, Jing Bai.
J Cancer Res Clin Oncol, 2012 Nov 13; 139(3). PMID: 23143646
Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.
Ravi Thakur, Rachana Trivedi, +2 authors, Durga Prasad Mishra.
Sci Rep, 2015 May 15; 5. PMID: 25973915    Free PMC article.
Highly Cited.
Identification and characterization of cells with cancer stem cell properties in human primary lung cancer cell lines.
Ping Wang, Quanli Gao, +7 authors, Gustav Gaudernack.
PLoS One, 2013 Mar 08; 8(3). PMID: 23469181    Free PMC article.
Highly Cited.
Vessel co-option in cancer.
Elizabeth A Kuczynski, Peter B Vermeulen, +2 authors, Andrew R Reynolds.
Nat Rev Clin Oncol, 2019 Mar 01; 16(8). PMID: 30816337
Highly Cited. Review.
Crossing the endothelial barrier during metastasis.
Nicolas Reymond, Bárbara Borda d'Água, Anne J Ridley.
Nat Rev Cancer, 2013 Nov 23; 13(12). PMID: 24263189
Highly Cited. Review.
Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship.
Irina M Shapiro, Vihren N Kolev, +10 authors, Jonathan A Pachter.
Sci Transl Med, 2014 May 23; 6(237). PMID: 24848258    Free PMC article.
Highly Cited.
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.
Laura R Saunders, Alexander J Bankovich, +30 authors, Scott J Dylla.
Sci Transl Med, 2015 Aug 28; 7(302). PMID: 26311731    Free PMC article.
Highly Cited.
Identification of uPAR-positive chemoresistant cells in small cell lung cancer.
Margarita Gutova, Joseph Najbauer, +4 authors, Karen S Aboody.
PLoS One, 2007 Mar 01; 2(2). PMID: 17327908    Free PMC article.
Characterization of sphere-forming cells with stem-like properties from the small cell lung cancer cell line H446.
Xiaofei Qiu, Zhengyan Wang, +3 authors, Yajing Luan.
Cancer Lett, 2012 Apr 24; 323(2). PMID: 22521544
Regulation of growth factor signaling and cell cycle progression by cell adhesion and adhesion-dependent changes in cellular tension.
Janice L Walker, Alaina K Fournier, Richard K Assoian.
Cytokine Growth Factor Rev, 2005 May 12; 16(4-5). PMID: 15886049
Review.
Elevated focal adhesion kinase expression facilitates oral tumor cell invasion.
Galen B Schneider, Zoya Kurago, +3 authors, Mary J C Hendrix.
Cancer, 2002 Dec 06; 95(12). PMID: 12467064
High FAK combined with low JWA expression: clinical prognostic and predictive role for adjuvant fluorouracil-leucovorin-oxaliplatin treatment in resectable gastric cancer patients.
Yansu Chen, Xiaowei Xia, +9 authors, Jianwei Zhou.
J Gastroenterol, 2013 Jan 12; 48(9). PMID: 23307041
Trends, predictors, and impact of systemic chemotherapy in small cell lung cancer patients between 1985 and 2005.
Madhusmita Behera, Camille Ragin, +8 authors, Taofeek K Owonikoko.
Cancer, 2015 Oct 07; 122(1). PMID: 26441041    Free PMC article.
Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer.
Luis Paz-Ares, Alexander Luft, +20 authors, KEYNOTE-407 Investigators.
N Engl J Med, 2018 Oct 04; 379(21). PMID: 30280635
Highly Cited.
Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer.
M Catherine Pietanza, Saiama N Waqar, +21 authors, Lauren Averett Byers.
J Clin Oncol, 2018 Jun 16; 36(23). PMID: 29906251    Free PMC article.
Highly Cited.
CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist.
Sana Sarvi, Alison C Mackinnon, +7 authors, Tariq Sethi.
Cancer Res, 2014 Jan 18; 74(5). PMID: 24436149
Highly Cited.
Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells.
Robert W Tilghman, Jill K Slack-Davis, +6 authors, J Thomas Parsons.
J Cell Sci, 2005 May 26; 118(Pt 12). PMID: 15914540
Expression of FAK and PTEN in bronchioloalveolar carcinoma and lung adenocarcinoma.
Changli Wang, Ran Yang, Dongsheng Yue, Zhenfa Zhang.
Lung, 2009 Feb 27; 187(2). PMID: 19242756
Expression of transforming growth factor beta (TGF beta) receptors and expression of TGF beta 1, TGF beta 2 and TGF beta 3 in human small cell lung cancer cell lines.
L Damstrup, K Rygaard, M Spang-Thomsen, H Skovgaard Poulsen.
Br J Cancer, 1993 May 01; 67(5). PMID: 8388229    Free PMC article.
Focal adhesion kinase and its potential involvement in tumor invasion and metastasis.
L J Kornberg.
Head Neck, 1998 Oct 28; 20(8). PMID: 9790298
Review.
Focal adhesion kinase: predictor of tumour response and risk factor for recurrence after neoadjuvant chemoradiation in rectal cancer.
Teresa Gómez Del Pulgar, Arancha Cebrián, +10 authors, Jesús García-Foncillas.
J Cell Mol Med, 2016 May 14; 20(9). PMID: 27171907    Free PMC article.
Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells.
Xianhui Wang, Alison M Urvalek, Jinsong Liu, Jihe Zhao.
J Biol Chem, 2008 Mar 21; 283(20). PMID: 18353772
Focal adhesion kinase (FAK)-dependent regulation of S-phase kinase-associated protein-2 (Skp-2) stability. A novel mechanism regulating smooth muscle cell proliferation.
Mark Bond, Graciela B Sala-Newby, Andrew C Newby.
J Biol Chem, 2004 Jun 23; 279(36). PMID: 15208331
β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy.
Iris Eke, Yvonne Deuse, +6 authors, Nils Cordes.
J Clin Invest, 2012 Mar 02; 122(4). PMID: 22378044    Free PMC article.
Highly Cited.
PD-L1 expression in cancer patients receiving anti PD-1/PD-L1 antibodies: A systematic review and meta-analysis.
Sara Gandini, Daniela Massi, Mario Mandalà.
Crit Rev Oncol Hematol, 2016 Feb 21; 100. PMID: 26895815
Highly Cited. Systematic Review.
Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation.
Tadashi Kasahara, Emiko Koguchi, +2 authors, Yoshiko Sonoda.
Antioxid Redox Signal, 2002 Sep 07; 4(3). PMID: 12215217
The prognostic value of whole blood SOX2, NANOG and OCT4 mRNA expression in advanced small-cell lung cancer.
Eva Sodja, Matija Rijavec, +3 authors, Tanja Cufer.
Radiol Oncol, 2016 Jun 02; 50(2). PMID: 27247551    Free PMC article.
Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein.
Elena Kurenova, Li-Hui Xu, +5 authors, William G Cance.
Mol Cell Biol, 2004 May 04; 24(10). PMID: 15121855    Free PMC article.
Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors.
L V Owens, L Xu, +5 authors, W G Cance.
Cancer Res, 1995 Jul 01; 55(13). PMID: 7796399
Highly Cited.
Focal adhesion kinase as a marker of malignant phenotype in breast and cervical carcinomas.
Maja H Oktay, Kutluk Oktay, +2 authors, Leopold G Koss.
Hum Pathol, 2003 Apr 04; 34(3). PMID: 12673558
Maintenance Defactinib Versus Placebo After First-Line Chemotherapy in Patients With Merlin-Stratified Pleural Mesothelioma: COMMAND-A Double-Blind, Randomized, Phase II Study.
Dean A Fennell, Paul Baas, +12 authors, Joachim G J V Aerts.
J Clin Oncol, 2019 Feb 21; 37(10). PMID: 30785827
Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide.
A T Turrisi, K Kim, +6 authors, D H Johnson.
N Engl J Med, 1999 Jan 28; 340(4). PMID: 9920950
Highly Cited.
Cellular characterization of a novel focal adhesion kinase inhibitor.
Jill K Slack-Davis, Karen H Martin, +8 authors, J Thomas Parsons.
J Biol Chem, 2007 Mar 31; 282(20). PMID: 17395594
Highly Cited.
Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis.
Harry M Lightfoot, Amy Lark, +5 authors, William G Cance.
Breast Cancer Res Treat, 2004 Nov 27; 88(2). PMID: 15564794
Cancer stem cells in small cell lung cancer.
Jordi Codony-Servat, Alberto Verlicchi, Rafael Rosell.
Transl Lung Cancer Res, 2016 Mar 10; 5(1). PMID: 26958490    Free PMC article.
Review.
High circulating hepatocyte growth factor levels associate with epithelial to mesenchymal transition and poor outcome in small cell lung cancer patients.
Israel Cañadas, Alvaro Taus, +13 authors, Edurne Arriola.
Oncotarget, 2014 Jul 16; 5(14). PMID: 25026301    Free PMC article.
Focal adhesion kinase expression in human neuroblastoma: immunohistochemical and real-time PCR analyses.
Elizabeth A Beierle, Nicole A Massoll, +5 authors, Wendy B London.
Clin Cancer Res, 2008 Jun 04; 14(11). PMID: 18519756
High pre-treatment serum level of vascular endothelial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer.
P Salven, T Ruotsalainen, K Mattson, H Joensuu.
Int J Cancer, 1998 May 16; 79(2). PMID: 9583728
Platelets increase the proliferation of ovarian cancer cells.
Min Soon Cho, Justin Bottsford-Miller, +5 authors, Vahid Afshar-Kharghan.
Blood, 2012 Sep 12; 120(24). PMID: 22966171    Free PMC article.
TGFbeta-induced EMT requires focal adhesion kinase (FAK) signaling.
Carla Cicchini, Ilaria Laudadio, +6 authors, Marco Tripodi.
Exp Cell Res, 2007 Oct 24; 314(1). PMID: 17949712
Highly Cited.
Endogenous DNA Damage as a Source of Genomic Instability in Cancer.
Anthony Tubbs, André Nussenzweig.
Cell, 2017 Feb 12; 168(4). PMID: 28187286    Free PMC article.
Highly Cited. Review.
Randomized phase II study of bevacizumab in combination with chemotherapy in previously untreated extensive-stage small-cell lung cancer: results from the SALUTE trial.
David R Spigel, Peter M Townley, +7 authors, Mark A Socinski.
J Clin Oncol, 2011 Apr 20; 29(16). PMID: 21502556
Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment.
Jayme B Stokes, Sara J Adair, +10 authors, Todd W Bauer.
Mol Cancer Ther, 2011 Sep 10; 10(11). PMID: 21903606    Free PMC article.
Highly Cited.
Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis.
Wei Lu, Yibin Kang.
Dev Cell, 2019 May 08; 49(3). PMID: 31063755    Free PMC article.
Highly Cited. Review.
Stemness and inducing differentiation of small cell lung cancer NCI-H446 cells.
Z Zhang, Y Zhou, +9 authors, W Xu.
Cell Death Dis, 2013 May 18; 4. PMID: 23681228    Free PMC article.
Durvalumab in Combination with Olaparib in Patients with Relapsed SCLC: Results from a Phase II Study.
Anish Thomas, Rasa Vilimas, +19 authors, Jung-Min Lee.
J Thorac Oncol, 2019 May 08; 14(8). PMID: 31063862    Free PMC article.
Highly Cited.
Etoposide and cisplatin versus irinotecan and cisplatin in patients with limited-stage small-cell lung cancer treated with etoposide and cisplatin plus concurrent accelerated hyperfractionated thoracic radiotherapy (JCOG0202): a randomised phase 3 study.
Kaoru Kubota, Toyoaki Hida, +18 authors, Japan Clinical Oncology Group.
Lancet Oncol, 2013 Dec 07; 15(1). PMID: 24309370
Complex networks orchestrate epithelial-mesenchymal transitions.
Jean Paul Thiery, Jonathan P Sleeman.
Nat Rev Mol Cell Biol, 2006 Feb 24; 7(2). PMID: 16493418
Highly Cited. Review.
Current Treatments for Surgically Resectable, Limited-Stage, and Extensive-Stage Small Cell Lung Cancer.
Thomas E Stinchcombe.
Oncologist, 2017 Aug 06; 22(12). PMID: 28778960    Free PMC article.
Review.
Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies.
Maja J A de Jonge, Neeltje Steeghs, +10 authors, Lillian L Siu.
Target Oncol, 2019 Feb 14; 14(1). PMID: 30756308    Free PMC article.
Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition.
Egle Avizienyte, Margaret C Frame.
Curr Opin Cell Biol, 2005 Aug 16; 17(5). PMID: 16099634
p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain.
Qiang Ding, J Robert Grammer, +3 authors, Candece L Gladson.
J Biol Chem, 2004 Nov 24; 280(8). PMID: 15557280
Ligand bound beta1 integrins inhibit procaspase-8 for mediating cell adhesion-mediated drug and radiation resistance in human leukemia cells.
Doris Estrugo, Alexander Fischer, +3 authors, Nils Cordes.
PLoS One, 2007 Mar 08; 2(3). PMID: 17342203    Free PMC article.
Oncogenic kinase signalling.
P Blume-Jensen, T Hunter.
Nature, 2001 May 18; 411(6835). PMID: 11357143
Highly Cited. Review.
Expression and clinical significance of focal adhesion kinase and adrenomedullin in epithelial ovarian cancer.
Mingqun Li, L I Hong, Meimei Liao, Guanglin Guo.
Oncol Lett, 2015 Dec 02; 10(2). PMID: 26622614    Free PMC article.
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.
Hong Jiang, Samarth Hegde, +10 authors, David G DeNardo.
Nat Med, 2016 Jul 05; 22(8). PMID: 27376576    Free PMC article.
Highly Cited.
High resolution detection of mechanical forces exerted by locomoting fibroblasts on the substrate.
R J Pelham, Y l Wang.
Mol Biol Cell, 1999 Apr 10; 10(4). PMID: 10198048    Free PMC article.
Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration.
L A Cary, D C Han, +2 authors, J L Guan.
J Cell Biol, 1998 Feb 14; 140(1). PMID: 9425168    Free PMC article.
Highly Cited.
DNA damage and the balance between survival and death in cancer biology.
Wynand P Roos, Adam D Thomas, Bernd Kaina.
Nat Rev Cancer, 2015 Dec 19; 16(1). PMID: 26678314
Highly Cited. Review.
Focal adhesion kinase: an alternative focus for anti-angiogenesis therapy in ovarian cancer.
Rebecca L Stone, Keith A Baggerly, +14 authors, Anil K Sood.
Cancer Biol Ther, 2014 Apr 24; 15(7). PMID: 24755674    Free PMC article.
CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts.
Christophe Ginestier, Suling Liu, +10 authors, Max S Wicha.
J Clin Invest, 2010 Jan 07; 120(2). PMID: 20051626    Free PMC article.
Highly Cited.
Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer.
Martin Reck, Delvys Rodríguez-Abreu, +16 authors, KEYNOTE-024 Investigators.
N Engl J Med, 2016 Oct 11; 375(19). PMID: 27718847
Highly Cited.
The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma.
Asma Begum, Theodore Ewachiw, +18 authors, William Matsui.
PLoS One, 2017 Jul 12; 12(7). PMID: 28692661    Free PMC article.
Increased radioresistance of an in vitro transformed human small cell lung cancer cell line.
O Brodin, H Arnberg, J Bergh, S Nilsson.
Lung Cancer, 1995 Jun 01; 12(3). PMID: 7655829
Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation.
François Ghiringhelli, Pierre E Puig, +7 authors, Laurence Zitvogel.
J Exp Med, 2005 Sep 28; 202(7). PMID: 16186184    Free PMC article.
Highly Cited.
Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumors in vivo and promotes capillary tube formation of brain microvascular endothelial cells.
Henry Haskell, Meera Natarajan, +4 authors, Candece L Gladson.
Clin Cancer Res, 2003 Jun 11; 9(6). PMID: 12796381
A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK.
A Richardson, T Parsons.
Nature, 1996 Apr 11; 380(6574). PMID: 8606775
Highly Cited.
Integrins in mechanotransduction.
Akira Katsumi, A Wayne Orr, Eleni Tzima, Martin Alexander Schwartz.
J Biol Chem, 2004 Feb 13; 279(13). PMID: 14960578
Highly Cited. Review.
Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer.
Yu Kang, Wei Hu, +16 authors, Anil K Sood.
J Natl Cancer Inst, 2013 Sep 26; 105(19). PMID: 24062525    Free PMC article.
Focal adhesion kinase is required for blood vessel morphogenesis.
Dusko Ilic, Branka Kovacic, +4 authors, Caroline H Damsky.
Circ Res, 2003 Feb 22; 92(3). PMID: 12595342
Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer.
Marcus C B Tan, Peter S Goedegebuure, +6 authors, David C Linehan.
J Immunol, 2009 Jan 22; 182(3). PMID: 19155524    Free PMC article.
Highly Cited.
Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion.
P C Ma, M S Tretiakova, +3 authors, R Salgia.
Br J Cancer, 2007 Aug 02; 97(3). PMID: 17667909    Free PMC article.
The Role of Cancer Stem Cells in Recurrent and Drug-Resistant Lung Cancer.
Raagini Suresh, Shadan Ali, +2 authors, Fazlul H Sarkar.
Adv Exp Med Biol, 2015 Dec 26; 890. PMID: 26703799
Review.
A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors.
J C Soria, H K Gan, +20 authors, M Millward.
Ann Oncol, 2016 Oct 14; 27(12). PMID: 27733373
Oct-3/4 promotes migration and invasion of glioblastoma cells.
Kana Kobayashi, Hisaaki Takahashi, +8 authors, Junya Tanaka.
J Cell Biochem, 2011 Sep 23; 113(2). PMID: 21938739
Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial.
Achim Rittmeyer, Fabrice Barlesi, +23 authors, OAK Study Group.
Lancet, 2016 Dec 17; 389(10066). PMID: 27979383    Free PMC article.
Highly Cited.
Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle.
M Oktay, K K Wary, +2 authors, F G Giancotti.
J Cell Biol, 1999 Jun 29; 145(7). PMID: 10385525    Free PMC article.
Making the first move in EGFR-driven or ALK-driven NSCLC: first-generation or next-generation TKI?
Gonzalo Recondo, Francesco Facchinetti, +2 authors, Luc Friboulet.
Nat Rev Clin Oncol, 2018 Aug 16; 15(11). PMID: 30108370
Highly Cited. Review.
Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/Cip1 through Skp2-dependent and -independent mechanisms.
Patrick Bryant, Qingxia Zheng, Kevin Pumiglia.
Mol Cell Biol, 2006 May 18; 26(11). PMID: 16705171    Free PMC article.
The role of platelet activation in tumor metastasis.
Lubor Borsig.
Expert Rev Anticancer Ther, 2008 Aug 14; 8(8). PMID: 18699763
Review.
Focal adhesion kinase signaling in unexpected places.
Elizabeth G Kleinschmidt, David D Schlaepfer.
Curr Opin Cell Biol, 2017 Feb 19; 45. PMID: 28213315    Free PMC article.
Highly Cited. Review.
Phase I Study of the Focal Adhesion Kinase Inhibitor BI 853520 in Japanese and Taiwanese Patients with Advanced or Metastatic Solid Tumors.
Toshihiko Doi, James Chih-Hsin Yang, +6 authors, Chia-Chi Lin.
Target Oncol, 2019 Feb 07; 14(1). PMID: 30725402    Free PMC article.
IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks.
Bryan Serrels, Niamh McGivern, +9 authors, Margaret C Frame.
Sci Signal, 2017 Dec 07; 10(508). PMID: 29208683    Free PMC article.
Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.
K Burridge, C E Turner, L H Romer.
J Cell Biol, 1992 Nov 01; 119(4). PMID: 1385444    Free PMC article.
Highly Cited.
Argonaute2 promotes tumor metastasis by way of up-regulating focal adhesion kinase expression in hepatocellular carcinoma.
Na Cheng, Yandong Li, Ze-Guang Han.
Hepatology, 2012 Dec 22; 57(5). PMID: 23258480
The significance of proline-rich tyrosine kinase2 (Pyk2) on hepatocellular carcinoma progression and recurrence.
C K Sun, K T Ng, +8 authors, S T Fan.
Br J Cancer, 2007 Jun 07; 97(1). PMID: 17551499    Free PMC article.
Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites.
Vita Golubovskaya, Aparna Kaur, William Cance.
Biochim Biophys Acta, 2004 May 26; 1678(2-3). PMID: 15157737
Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling.
Markus Schober, Elaine Fuchs.
Proc Natl Acad Sci U S A, 2011 Jun 15; 108(26). PMID: 21670270    Free PMC article.
Highly Cited.
Up-regulation of focal adhesion kinase in non-small cell lung cancer.
Stephana Carelli, Giorgia Zadra, +6 authors, Silvano Bosari.
Lung Cancer, 2006 Jul 18; 53(3). PMID: 16842883
Pembrolizumab for the treatment of non-small-cell lung cancer.
Edward B Garon, Naiyer A Rizvi, +25 authors, KEYNOTE-001 Investigators.
N Engl J Med, 2015 Apr 22; 372(21). PMID: 25891174
Highly Cited.
Focal adhesion kinase overexpression: correlation with lymph node metastasis and shorter survival in oral squamous cell carcinoma.
Juan Carlos de Vicente, Pablo Rosado, +3 authors, Gonzalo Hernández-Vallejo.
Head Neck, 2012 Jul 19; 35(6). PMID: 22807117
Pazopanib maintenance after first-line etoposide and platinum chemotherapy in patients with extensive disease small-cell lung cancer: a multicentre, randomised, placebo-controlled Phase II study (KCSG-LU12-07).
Jong-Mu Sun, Ki Hyeong Lee, +9 authors, Myung-Ju Ahn.
Br J Cancer, 2018 Jan 31; 118(5). PMID: 29381690    Free PMC article.
The FAK inhibitor BI 853520 exerts anti-tumor effects in breast cancer.
Stefanie Tiede, Nathalie Meyer-Schaller, +10 authors, Gerhard Christofori.
Oncogenesis, 2018 Sep 22; 7(9). PMID: 30237500    Free PMC article.
Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated.
Baotran Ho, Gretchen Olson, +3 authors, Vita M Golubovskaya.
J Biol Chem, 2012 Apr 12; 287(22). PMID: 22493428    Free PMC article.
Characteristics and Outcomes of Small Cell Lung Cancer Detected by CT Screening.
Anish Thomas, Puskar Pattanayak, Eva Szabo, Paul Pinsky.
Chest, 2018 Aug 07; 154(6). PMID: 30080997    Free PMC article.
Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer.
Cassandra L Hodgkinson, Christopher J Morrow, +23 authors, Caroline Dive.
Nat Med, 2014 Jun 02; 20(8). PMID: 24880617
Highly Cited.
Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.
Colin Walsh, Isabelle Tanjoni, +9 authors, David D Schlaepfer.
Cancer Biol Ther, 2010 Mar 18; 9(10). PMID: 20234193    Free PMC article.
Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration.
D J Sieg, C R Hauck, D D Schlaepfer.
J Cell Sci, 1999 Jul 22; 112 ( Pt 16). PMID: 10413676
Highly Cited.
Focal adhesion kinase overexpression and its impact on human osteosarcoma.
Ke Ren, Xiao Lu, +8 authors, Xiaoliang Sun.
Oncotarget, 2015 Sep 24; 6(31). PMID: 26393679    Free PMC article.
Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis.
Myriam Labelle, Shahinoor Begum, Richard O Hynes.
Cancer Cell, 2011 Nov 19; 20(5). PMID: 22094253    Free PMC article.
Highly Cited.
Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.
Elena V Kurenova, Darell L Hunt, +3 authors, William G Cance.
J Med Chem, 2009 Jul 21; 52(15). PMID: 19610651    Free PMC article.
Expression of focal adhesion kinase in uveal melanoma and the effects of Hsp90 inhibition by 17-AAG.
Dana Faingold, Vasco Bravo Filho, +5 authors, Miguel N Burnier.
Pathol Res Pract, 2014 Jul 22; 210(11). PMID: 25041838
A study of the focal adhesion kinase inhibitor GSK2256098 in patients with recurrent glioblastoma with evaluation of tumor penetration of [11C]GSK2256098.
Nicholas F Brown, Matthew Williams, +14 authors, Paul Mulholland.
Neuro Oncol, 2018 May 23; 20(12). PMID: 29788497    Free PMC article.
Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy.
Bernardo Tavora, Louise E Reynolds, +13 authors, Kairbaan M Hodivala-Dilke.
Nature, 2014 Aug 01; 514(7520). PMID: 25079333    Free PMC article.
Distinct FAK activities determine progenitor and mammary stem cell characteristics.
Ming Luo, Xiaofeng Zhao, +3 authors, Jun-Lin Guan.
Cancer Res, 2013 Jul 09; 73(17). PMID: 23832665    Free PMC article.
High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype.
Amy L Lark, Chad A Livasy, +8 authors, William Cance.
Mod Pathol, 2005 Apr 30; 18(10). PMID: 15861214
Focal adhesion kinase as a cancer therapy target.
Vita M Golubovskaya.
Anticancer Agents Med Chem, 2011 Jan 11; 10(10). PMID: 21214510    Free PMC article.
Review.
Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer.
Hossein Borghaei, Luis Paz-Ares, +25 authors, Julie R Brahmer.
N Engl J Med, 2015 Sep 29; 373(17). PMID: 26412456    Free PMC article.
Highly Cited.
PIAS1-FAK Interaction Promotes the Survival and Progression of Non-Small Cell Lung Cancer.
Jerfiz D Constanzo, Ke-Jing Tang, +6 authors, Pier Paolo Scaglioni.
Neoplasia, 2016 May 31; 18(5). PMID: 27237320    Free PMC article.
Fibronectin extra domain A (EDA) sustains CD133(+)/CD44(+) subpopulation of colorectal cancer cells.
Juanjuan Ou, Jia Deng, +4 authors, Houjie Liang.
Stem Cell Res, 2013 Jul 03; 11(2). PMID: 23811539    Free PMC article.
Identification and expansion of the tumorigenic lung cancer stem cell population.
A Eramo, F Lotti, +7 authors, R De Maria.
Cell Death Differ, 2007 Dec 01; 15(3). PMID: 18049477
Highly Cited.
Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis.
Xiao-Qing Zeng, Na Li, +3 authors, Shi-Yao Chen.
PLoS One, 2016 Sep 17; 11(9). PMID: 27637100    Free PMC article.
DNA damage, aging, and cancer.
Jan H J Hoeijmakers.
N Engl J Med, 2009 Oct 09; 361(15). PMID: 19812404
Highly Cited. Review.
Integrin β1 regulates the invasion and radioresistance of laryngeal cancer cells by targeting CD147.
Li Li, Xiaoxia Dong, Feng Peng, Li Shen.
Cancer Cell Int, 2018 Jun 23; 18. PMID: 29930482    Free PMC article.
Increased circulating CD14(+)HLA-DR-/low myeloid-derived suppressor cells are associated with poor prognosis in patients with small-cell lung cancer.
Tian Tian, Xiaobin Gu, +5 authors, Kexing Fan.
Cancer Biomark, 2015 Mar 21; 15(4). PMID: 25792471
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly.
Donna J Webb, Karen Donais, +4 authors, Alan F Horwitz.
Nat Cell Biol, 2004 Jan 27; 6(2). PMID: 14743221
Highly Cited.
Cancer-FOXP3 directly activated CCL5 to recruit FOXP3+Treg cells in pancreatic ductal adenocarcinoma.
X Wang, M Lang, +12 authors, H Ren.
Oncogene, 2016 Dec 20; 36(21). PMID: 27991933    Free PMC article.
CCL1 is a major regulatory T cell attracting factor in human breast cancer.
Benjamin Kuehnemuth, Ignazio Piseddu, +8 authors, David Anz.
BMC Cancer, 2018 Dec 24; 18(1). PMID: 30572845    Free PMC article.
Metastasis: Circulating Tumor Cells in Small Cell Lung Cancer.
Gerhard Hamilton, Doris Moser, Maximilian Hochmair.
Trends Cancer, 2016 Apr 01; 2(4). PMID: 28741567
Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression.
J Zhao, R Pestell, J L Guan.
Mol Biol Cell, 2001 Dec 12; 12(12). PMID: 11739801    Free PMC article.
A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors.
Suzanne F Jones, Lillian L Siu, +10 authors, Geoffrey I Shapiro.
Invest New Drugs, 2015 Sep 04; 33(5). PMID: 26334219
Focal adhesion kinase and p53 signaling in cancer cells.
Vita M Golubovskaya, William G Cance.
Int Rev Cytol, 2007 Aug 30; 263. PMID: 17725966
Review.
Somatic Mutations and Splicing Variants of Focal Adhesion Kinase in Non-Small Cell Lung Cancer.
Bo Zhou, Gui-Zhen Wang, +4 authors, Guang-Biao Zhou.
J Natl Cancer Inst, 2017 Nov 01; 110(2). PMID: 29087503
Cell migration: integrating signals from front to back.
Anne J Ridley, Martin A Schwartz, +5 authors, Alan Rick Horwitz.
Science, 2003 Dec 06; 302(5651). PMID: 14657486
Highly Cited. Review.
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.
A C Carrano, E Eytan, A Hershko, M Pagano.
Nat Cell Biol, 1999 Nov 13; 1(4). PMID: 10559916
Highly Cited.
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression.
A Cano, M A Pérez-Moreno, +5 authors, M A Nieto.
Nat Cell Biol, 2000 Feb 03; 2(2). PMID: 10655586
Highly Cited.
Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma.
Shinji Itoh, Takashi Maeda, +4 authors, Yoshihiko Maehara.
Clin Cancer Res, 2004 Apr 23; 10(8). PMID: 15102689
In vitro chemo- and radio-resistance in small cell lung cancer correlates with cell adhesion and constitutive activation of AKT and MAP kinase pathways.
Alison C Kraus, Ines Ferber, +6 authors, Marcus Schuermann.
Oncogene, 2002 Dec 17; 21(57). PMID: 12483521
DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway.
S Ocak, H Yamashita, +9 authors, P P Massion.
Oncogene, 2010 Aug 31; 29(48). PMID: 20802517    Free PMC article.
Localization of FAK is related with colorectal carcinogenesis.
Toshihiro Murata, Yoshio Naomoto, +9 authors, Noriaki Tanaka.
Int J Oncol, 2008 Mar 25; 32(4). PMID: 18360706
Stem Cell Factor-Based Identification and Functional Properties of In Vitro-Selected Subpopulations of Malignant Mesothelioma Cells.
Walter Blum, László Pecze, +3 authors, Beat Schwaller.
Stem Cell Reports, 2017 Mar 14; 8(4). PMID: 28285878    Free PMC article.
Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression.
Jihe Zhao, Z Christine Bian, +3 authors, Jun-Lin Guan.
Mol Cell, 2003 Jun 25; 11(6). PMID: 12820964
Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.
M Agochiya, V G Brunton, +4 authors, M C Frame.
Oncogene, 1999 Oct 19; 18(41). PMID: 10523844
v-Src SH3-enhanced interaction with focal adhesion kinase at beta 1 integrin-containing invadopodia promotes cell invasion.
Christof R Hauck, Datsun A Hsia, Dusko Ilic, David D Schlaepfer.
J Biol Chem, 2002 Feb 13; 277(15). PMID: 11839732
FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal.
Monika Haemmerle, Justin Bottsford-Miller, +21 authors, Anil K Sood.
J Clin Invest, 2016 Apr 12; 126(5). PMID: 27064283    Free PMC article.
Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database.
Ramaswamy Govindan, Nathan Page, +5 authors, Jay Piccirillo.
J Clin Oncol, 2006 Sep 30; 24(28). PMID: 17008692
Highly Cited.
Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion.
Xianhui Wang, Mingzhe Zheng, +4 authors, Jihe Zhao.
Cancer Res, 2007 Aug 03; 67(15). PMID: 17671186
Ionizing radiation modules of the expression and tyrosine phosphorylation of the focal adhesion-associated proteins focal adhesion kinase (FAK) and its substrates p130cas and paxillin in A549 human lung carcinoma cells in vitro.
C Beinke, D Van Beuningen, N Cordes.
Int J Radiat Biol, 2004 Jan 06; 79(9). PMID: 14703945
Vascular-specific growth factors and blood vessel formation.
G D Yancopoulos, S Davis, +3 authors, J Holash.
Nature, 2000 Sep 23; 407(6801). PMID: 11001067
Highly Cited. Review.
Focal adhesion kinase and E-cadherin as markers for nodal metastasis in laryngeal cancer.
Juan Pablo Rodrigo, Francisco Dominguez, +3 authors, Maria Dolores Chiara.
Arch Otolaryngol Head Neck Surg, 2007 Feb 21; 133(2). PMID: 17309983
Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes.
W G Cance, J E Harris, +5 authors, L Xu.
Clin Cancer Res, 2000 Jun 29; 6(6). PMID: 10873094
Highly Cited.
pFAK-Y397 overexpression as both a prognostic and a predictive biomarker for patients with metastatic osteosarcoma.
Kamolrat Thanapprapasr, Adisak Nartthanarung, Duangmani Thanapprapasr, Artit Jinawath.
PLoS One, 2017 Aug 29; 12(8). PMID: 28846700    Free PMC article.
The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma.
Viktoria Laszlo, Zsuzsanna Valko, +14 authors, Balazs Hegedus.
J Mol Med (Berl), 2018 Dec 13; 97(2). PMID: 30539198    Free PMC article.
Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study.
Sang Jin Kim, Jin Woo Park, +9 authors, Myung Hi Yoo.
J Korean Med Sci, 2004 Oct 16; 19(5). PMID: 15483349    Free PMC article.
Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice.
Xu Peng, Hiroki Ueda, +6 authors, Jun-Lin Guan.
Cardiovasc Res, 2004 Nov 13; 64(3). PMID: 15537495
The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth.
Elena Kurenova, Jianqun Liao, +5 authors, William G Cance.
Oncotarget, 2013 Oct 22; 4(10). PMID: 24142503    Free PMC article.
Cancer stem cells: an old idea--a paradigm shift.
Max S Wicha, Suling Liu, Gabriela Dontu.
Cancer Res, 2006 Feb 21; 66(4). PMID: 16488983
Highly Cited.
Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy.
Kathryn E Williams, Nigel J Bundred, +2 authors, Gillian Farnie.
Stem Cells, 2014 Sep 05; 33(2). PMID: 25187396
Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function.
Christine Jean, Xiao Lei Chen, +12 authors, David D Schlaepfer.
J Cell Biol, 2014 Jan 22; 204(2). PMID: 24446483    Free PMC article.
Focal adhesion kinase: a potential target in cancer therapy.
Maroesja J van Nimwegen, Bob van de Water.
Biochem Pharmacol, 2006 Sep 26; 73(5). PMID: 16997283
Review.
Blockade of CCL1 inhibits T regulatory cell suppressive function enhancing tumor immunity without affecting T effector responses.
Dominique B Hoelzinger, Shannon E Smith, +3 authors, Joseph Lustgarten.
J Immunol, 2010 May 21; 184(12). PMID: 20483762
A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours.
Gabriel Mak, Jean-Charles Soria, +13 authors, Hendrik-Tobias Arkenau.
Br J Cancer, 2019 Apr 18; 120(10). PMID: 30992546    Free PMC article.
Focal adhesion kinase expression is not a prognostic predictor in colon adenocarcinoma patients.
S E Theocharis, G P Kouraklis, +4 authors, A S Koutselinis.
Eur J Surg Oncol, 2003 Aug 29; 29(7). PMID: 12943621
Conversion of Stem Cells to Cancer Stem Cells: Undercurrent of Cancer Initiation.
Said M Afify, Masaharu Seno.
Cancers (Basel), 2019 Mar 14; 11(3). PMID: 30862050    Free PMC article.
Highly Cited. Review.
Comprehensive genomic profiles of small cell lung cancer.
Julie George, Jing Shan Lim, +93 authors, Roman K Thomas.
Nature, 2015 Jul 15; 524(7563). PMID: 26168399    Free PMC article.
Highly Cited.
Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer.
Jun-Lin Guan.
IUBMB Life, 2010 Jan 27; 62(4). PMID: 20101634    Free PMC article.
Review.
A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth.
Qing Shi, Anita B Hjelmeland, +7 authors, Jeremy N Rich.
Mol Carcinog, 2007 Jan 16; 46(6). PMID: 17219439
FAK in cancer: mechanistic findings and clinical applications.
Florian J Sulzmaier, Christine Jean, David D Schlaepfer.
Nat Rev Cancer, 2014 Aug 08; 14(9). PMID: 25098269    Free PMC article.
Highly Cited. Review.
Unravelling the biology of SCLC: implications for therapy.
Joshua K Sabari, Benjamin H Lok, +2 authors, Charles M Rudin.
Nat Rev Clin Oncol, 2017 May 24; 14(9). PMID: 28534531    Free PMC article.
Highly Cited. Review.
FAK overexpression and p53 mutations are highly correlated in human breast cancer.
Vita M Golubovskaya, Kathleen Conway-Dorsey, +6 authors, William G Cance.
Int J Cancer, 2009 Jun 13; 125(7). PMID: 19521985    Free PMC article.
Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.
Sara M Weis, Ssang-Taek Lim, +7 authors, David A Cheresh.
J Cell Biol, 2008 Apr 09; 181(1). PMID: 18391070    Free PMC article.
The cell-cell interaction between tumor-associated macrophages and small cell lung cancer cells is involved in tumor progression via STAT3 activation.
Toyohisa Iriki, Koji Ohnishi, +10 authors, Yoshihiro Komohara.
Lung Cancer, 2017 Mar 14; 106. PMID: 28285690
Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer.
Leena Gandhi, Delvys Rodríguez-Abreu, +27 authors, KEYNOTE-189 Investigators.
N Engl J Med, 2018 Apr 17; 378(22). PMID: 29658856
Highly Cited.
Regulation of the cell cycle by focal adhesion kinase.
J H Zhao, H Reiske, J L Guan.
J Cell Biol, 1998 Dec 29; 143(7). PMID: 9864370    Free PMC article.
VEGF-induced vascular permeability is mediated by FAK.
Xiao Lei Chen, Ju-Ock Nam, +12 authors, David D Schlaepfer.
Dev Cell, 2012 Jan 24; 22(1). PMID: 22264731    Free PMC article.
Highly Cited.
FAK and Nanog cross talk with p53 in cancer stem cells.
Vita M Golubovskaya.
Anticancer Agents Med Chem, 2012 Sep 01; 13(4). PMID: 22934707    Free PMC article.
Review.
Control of adhesion-dependent cell survival by focal adhesion kinase.
S M Frisch, K Vuori, E Ruoslahti, P Y Chan-Hui.
J Cell Biol, 1996 Aug 01; 134(3). PMID: 8707856    Free PMC article.
Highly Cited.
Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro.
Grace M Lau, Gillian M Lau, +4 authors, Jane W S Fang.
Dig Dis Sci, 2008 Nov 04; 54(7). PMID: 18979199
Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor.
Tsutomu Fujii, Katsumi Koshikawa, +6 authors, Akimasa Nakao.
J Hepatol, 2004 Jul 13; 41(1). PMID: 15246215
Dynamics of regulatory T cells (Tregs ) in patients with oral squamous cell carcinoma.
Sadhna Aggarwal, Suresh C Sharma, Satya N Das.
J Surg Oncol, 2017 Aug 24; 116(8). PMID: 28833201
Clinical significance of high focal adhesion kinase gene copy number and overexpression in invasive breast cancer.
Cha Kyong Yom, Dong-Young Noh, Woo Ho Kim, Hee Sung Kim.
Breast Cancer Res Treat, 2010 Sep 04; 128(3). PMID: 20814816
Expression of focal adhesion kinase in normal and pathologic human prostate tissues.
Joshua D Rovin, Henry F Frierson, +2 authors, Reid B Adams.
Prostate, 2002 Sep 21; 53(2). PMID: 12242727
Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells.
Rosalyn B Irby, Timothy J Yeatman.
Cancer Res, 2002 May 01; 62(9). PMID: 11980666
Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors.
Jeffrey R Infante, D Ross Camidge, +10 authors, Lillian L Siu.
J Clin Oncol, 2012 Mar 29; 30(13). PMID: 22454420
Highly Cited.
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.
Vita M Golubovskaya, Baotran Ho, +4 authors, William G Cance.
BMC Cancer, 2013 Jul 12; 13. PMID: 23841915    Free PMC article.
Neuropeptides stimulate tyrosine phosphorylation and tyrosine kinase activity in small cell lung cancer cell lines.
A Tallett, E R Chilvers, +2 authors, T Sethi.
Peptides, 1996 Jan 01; 17(4). PMID: 8804078
Association of focal adhesion kinase with Grb7 and its role in cell migration.
D C Han, J L Guan.
J Biol Chem, 1999 Aug 14; 274(34). PMID: 10446223
FAK regulates biological processes important for the pathogenesis of cancer.
Veronica Gabarra-Niecko, Michael D Schaller, Jill M Dunty.
Cancer Metastasis Rev, 2003 Jul 30; 22(4). PMID: 12884911
Highly Cited. Review.
Prognostic significance of expression of nm23-H1 and focal adhesion kinase in non-small cell lung cancer.
Nan-Yung Hsu, Chih-Yi Chen, +4 authors, Kuan-Chih Chow.
Oncol Rep, 2007 Jun 06; 18(1). PMID: 17549350
Effects of extracellular matrix on the response of endothelial cells to radiation in vitro.
Z Fuks, I Vlodavsky, +2 authors, A Haimovitz-Friedman.
Eur J Cancer, 1992 Jan 01; 28A(4-5). PMID: 1524892
Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.
J D Owen, P J Ruest, D W Fry, S K Hanks.
Mol Cell Biol, 1999 Jun 22; 19(7). PMID: 10373530    Free PMC article.
Highly Cited.
Bombesin and gastrin releasing peptide increase tyrosine phosphorylation of focal adhesion kinase and paxillin in non-small cell lung cancer cells.
J Leyton, L J Garcia-Marin, +2 authors, T W Moody.
Cancer Lett, 2000 Dec 21; 162(1). PMID: 11121866
First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer.
Leora Horn, Aaron S Mansfield, +19 authors, IMpower133 Study Group.
N Engl J Med, 2018 Oct 04; 379(23). PMID: 30280641
Highly Cited.
Focal adhesion kinase: the first ten years.
J Thomas Parsons.
J Cell Sci, 2003 Mar 18; 116(Pt 8). PMID: 12640026
Highly Cited. Review.
Expression and prognostic significance of focal adhesion kinase in hepatocellular carcinoma.
Zhou Yuan, Qi Zheng, +3 authors, Xin-yu Huang.
J Cancer Res Clin Oncol, 2010 Feb 13; 136(10). PMID: 20151150
Focal adhesion kinase (FAK) gene amplification and its clinical implications in gastric cancer.
Joo Hyun Park, Byung-Lan Lee, +4 authors, Woo Ho Kim.
Hum Pathol, 2010 Sep 28; 41(12). PMID: 20869748
Overexpression of focal adhesion kinase in head and neck squamous cell carcinoma is independent of fak gene copy number.
Marta Canel, Pablo Secades, +4 authors, María-Dolores Chiara.
Clin Cancer Res, 2006 Jun 03; 12(11 Pt 1). PMID: 16740747
Differential regulation of cell motility and invasion by FAK.
Datsun A Hsia, Satyajit K Mitra, +10 authors, David D Schlaepfer.
J Cell Biol, 2003 Mar 05; 160(5). PMID: 12615911    Free PMC article.
Highly Cited.
Rapidly growing small peripheral lung cancers detected by screening CT: correlation between radiological appearance and pathological features.
J C Wang, S Sone, +7 authors, T Yamanda.
Br J Radiol, 2000 Nov 07; 73(873). PMID: 11064644
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer.
Julie Brahmer, Karen L Reckamp, +22 authors, David R Spigel.
N Engl J Med, 2015 Jun 02; 373(2). PMID: 26028407    Free PMC article.
Highly Cited.
Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses.
Amy L Lark, Chad A Livasy, +4 authors, William G Cance.
Clin Cancer Res, 2003 Jan 23; 9(1). PMID: 12538472
Etoposide plus cisplatin with or without the combination of 4'-epidoxorubicin plus cyclophosphamide in treatment of extensive small-cell lung cancer: a French Federation of Cancer Institutes multicenter phase III randomized study.
J L Pujol, J P Daurès, +10 authors, T Le Chevalier.
J Natl Cancer Inst, 2001 Feb 22; 93(4). PMID: 11181777
Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1.
N Cordes, S Frick, +6 authors, E J Bernhard.
Oncogene, 2007 May 02; 26(48). PMID: 17471232
Phosphorylation of focal adhesion kinase at Tyr397 in gastric carcinomas and its clinical significance.
I-Rue Lai, Pei-Yu Chu, +4 authors, Tang-Long Shen.
Am J Pathol, 2010 Aug 21; 177(4). PMID: 20724588    Free PMC article.
Flotillin1 promotes EMT of human small cell lung cancer via TGF-β signaling pathway.
Lianmei Zhao, Jie Li, +7 authors, Qimin Zhan.
Cancer Biol Med, 2019 Feb 16; 15(4). PMID: 30766750    Free PMC article.
Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma.
Pablo Munguía-Calzada, Iván Fernández-Vega, +7 authors, Jorge Santos-Juanes.
Head Neck, 2018 Dec 12; 41(5). PMID: 30537291
Small-cell lung cancer: prognostic factors and changing treatment over 15 years.
Laurie E Gaspar, Erica J McNamara, +4 authors, James A Bonner.
Clin Lung Cancer, 2011 Oct 18; 13(2). PMID: 22000695
Small cell lung cancer tumour cells induce regulatory T lymphocytes, and patient survival correlates negatively with FOXP3+ cells in tumour infiltrate.
Wei Wang, Philip Hodkinson, +4 authors, Tariq Sethi.
Int J Cancer, 2012 Apr 26; 131(6). PMID: 22532287
Small cell lung cancer, an epithelial to mesenchymal transition (EMT)-like cancer: significance of inactive Notch signaling and expression of achaete-scute complex homologue 1.
Takaaki Ito, Shinji Kudoh, +3 authors, Naoko Udaka.
Hum Cell, 2016 Oct 28; 30(1). PMID: 27785690
Review.
Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression.
Kristy K Ward, Isabelle Tancioni, +9 authors, David D Schlaepfer.
Clin Exp Metastasis, 2013 Jan 01; 30(5). PMID: 23275034    Free PMC article.
Prognostic Significance of Focal Adhesion Kinase in Node-Negative Breast Cancer.
Katrin Almstedt, Isabel Sicking, +5 authors, Marcus Schmidt.
Breast Care (Basel), 2017 Dec 14; 12(5). PMID: 29234254    Free PMC article.
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.
Gordon W McLean, Neil O Carragher, +3 authors, Margaret C Frame.
Nat Rev Cancer, 2005 Aug 03; 5(7). PMID: 16069815
Highly Cited. Review.
Salinomycin attenuates liver cancer stem cell motility by enhancing cell stiffness and increasing F-actin formation via the FAK-ERK1/2 signalling pathway.
Jinghui Sun, Qing Luo, +3 authors, Guanbin Song.
Toxicology, 2017 Apr 12; 384. PMID: 28395993
Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.
Alan Serrels, Tom Lund, +15 authors, Margaret C Frame.
Cell, 2015 Sep 26; 163(1). PMID: 26406376    Free PMC article.
Highly Cited.
Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition.
Catherine Wilson, Katrina Nicholes, +5 authors, Jeff Settleman.
Oncotarget, 2014 Sep 07; 5(17). PMID: 25193862    Free PMC article.
Highly Cited.
Chemotherapy With or Without Maintenance Sunitinib for Untreated Extensive-Stage Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase II Study-CALGB 30504 (Alliance).
Neal E Ready, Herbert H Pang, +9 authors, Everett E Vokes.
J Clin Oncol, 2015 Mar 04; 33(15). PMID: 25732163    Free PMC article.
Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase.
E A Almeida, D Ilić, +5 authors, C H Damsky.
J Cell Biol, 2000 May 03; 149(3). PMID: 10791986    Free PMC article.
HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells.
L Beviglia, R H Kramer.
Int J Cancer, 1999 Oct 16; 83(5). PMID: 10521801
Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo.
Ta-Jen Liu, Tiffany LaFortune, +6 authors, W K Alfred Yung.
Mol Cancer Ther, 2007 Apr 14; 6(4). PMID: 17431114
Angiogenesis in cancer and other diseases.
P Carmeliet, R K Jain.
Nature, 2000 Sep 23; 407(6801). PMID: 11001068
Highly Cited. Review.
CAS/Crk coupling serves as a "molecular switch" for induction of cell migration.
R L Klemke, J Leng, +3 authors, D A Cheresh.
J Cell Biol, 1998 Mar 21; 140(4). PMID: 9472046    Free PMC article.
Highly Cited.
Focal adhesion kinase promotes progression and predicts poor clinical outcomes in patients with osteosarcoma.
Hua-Jie Gu, Bin Zhou.
Oncol Lett, 2018 Jun 01; 15(5). PMID: 29849782    Free PMC article.
Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK.
M D Schaller, C A Borgman, J T Parsons.
Mol Cell Biol, 1993 Feb 01; 13(2). PMID: 8423801    Free PMC article.
Highly Cited.
Focal adhesion kinase (FAK) immunocytochemical expression in breast ductal invasive carcinoma (DIC): correlation with clinicopathological parameters and tumor proliferative capacity.
Stamatios E Theocharis, Jerzy T Klijanienko, +2 authors, Xavier X Sastre-Garau.
Med Sci Monit, 2009 Aug 01; 15(8). PMID: 19644410
Cell migration: regulation of force on extracellular-matrix-integrin complexes.
M P Sheetz, D P Felsenfeld, C G Galbraith.
Trends Cell Biol, 1998 Aug 08; 8(2). PMID: 9695809
Highly Cited. Review.
Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells.
Xiao-Yan Li, Xiaoming Zhou, +7 authors, Stephen J Weiss.
J Cell Biol, 2011 Nov 23; 195(5). PMID: 22105351    Free PMC article.
Fragment-based discovery of new highly substituted 1H-pyrrolo[2,3-b]- and 3H-imidazolo[4,5-b]-pyridines as focal adhesion kinase inhibitors.
Timo Heinrich, Jeyaprakashnarayanan Seenisamy, +8 authors, Djordje Musil.
J Med Chem, 2013 Jan 09; 56(3). PMID: 23294348
Vasculogenic mimicry in small cell lung cancer.
Stuart C Williamson, Robert L Metcalf, +24 authors, Caroline Dive.
Nat Commun, 2016 Nov 09; 7. PMID: 27827359    Free PMC article.
Highly Cited.
FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells.
LaTonia Taliaferro-Smith, Elaine Oberlick, +11 authors, Ruth O'Regan.
Oncotarget, 2015 Mar 10; 6(7). PMID: 25749031    Free PMC article.
Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility.
Steven K Hanks, Larisa Ryzhova, Nah-Young Shin, Jan Brábek.
Front Biosci, 2003 Apr 18; 8. PMID: 12700132
Highly Cited. Review.
Association of the upregulated expression of focal adhesion kinase with poor prognosis and tumor dissemination in hypopharyngeal cancer.
Go Omura, Mizuo Ando, +9 authors, Tatsuya Yamasoba.
Head Neck, 2016 Apr 12; 38(8). PMID: 27061113
Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo.
Huaping Fan, Xiaofeng Zhao, +2 authors, Jun-Lin Guan.
J Biol Chem, 2012 Dec 21; 288(5). PMID: 23255596    Free PMC article.
Randomized, Open-Label, Crossover Studies Evaluating the Effect of Food and Liquid Formulation on the Pharmacokinetics of the Novel Focal Adhesion Kinase (FAK) Inhibitor BI 853520.
Remy B Verheijen, Diane A J van der Biessen, +9 authors, Martijn P Lolkema.
Target Oncol, 2019 Feb 12; 14(1). PMID: 30742245    Free PMC article.
A first-in-Asian phase 1 study to evaluate safety, pharmacokinetics and clinical activity of VS-6063, a focal adhesion kinase (FAK) inhibitor in Japanese patients with advanced solid tumors.
Toshio Shimizu, Kazuya Fukuoka, +8 authors, Kazuhiko Nakagawa.
Cancer Chemother Pharmacol, 2016 Mar 31; 77(5). PMID: 27025608    Free PMC article.
The increased adhesion of tumor cells to endothelial cells after irradiation can be reduced by FAK-inhibition.
Pascaline Nguemgo Kouam, Helmut Bühler, Thomas Hero, Irenäus A Adamietz.
Radiat Oncol, 2019 Feb 06; 14(1). PMID: 30717801    Free PMC article.
Reduced expression of focal adhesion kinase in liver metastases compared with matched primary human colorectal adenocarcinomas.
M Ayaki, K Komatsu, +6 authors, H Nakamura.
Clin Cancer Res, 2001 Oct 12; 7(10). PMID: 11595702
Targeting FAK radiosensitizes 3-dimensional grown human HNSCC cells through reduced Akt1 and MEK1/2 signaling.
Stephanie Hehlgans, Iris Eke, Nils Cordes.
Int J Radiat Oncol Biol Phys, 2012 Apr 10; 83(5). PMID: 22483702
Characterization of fibroblast growth factor receptor 1 in small-cell lung cancer.
Anish Thomas, Jih-Hsiang Lee, +7 authors, Giuseppe Giaccone.
J Thorac Oncol, 2014 Apr 17; 9(4). PMID: 24736083    Free PMC article.
The prognostic significance of focal adhesion kinase expression in stage I non-small-cell lung cancer.
Grace K Dy, Lourdes Ylagan, +6 authors, Vita M Golubovskaya.
J Thorac Oncol, 2014 Aug 15; 9(9). PMID: 25122425    Free PMC article.
Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer.
C D Salcido, A Larochelle, +2 authors, L Varticovski.
Br J Cancer, 2010 Apr 29; 102(11). PMID: 20424609    Free PMC article.
Small cell lung carcinoma (SCLC): the angiogenic phenomenon.
Marco Lucchi, Alfredo Mussi, +3 authors, Carlo Alberto Angeletti.
Eur J Cardiothorac Surg, 2002 Jun 06; 21(6). PMID: 12048093
The Interaction between Cancer Stem Cell Marker CD133 and Src Protein Promotes Focal Adhesion Kinase (FAK) Phosphorylation and Cell Migration.
Chanjuan Liu, Yinan Li, +6 authors, Jianhai Jiang.
J Biol Chem, 2016 May 27; 291(30). PMID: 27226554    Free PMC article.
Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study.
Charles M Rudin, M Catherine Pietanza, +21 authors, SCRX16-001 investigators.
Lancet Oncol, 2016 Dec 10; 18(1). PMID: 27932068    Free PMC article.
Highly Cited.
Coordinated regulation of myeloid cells by tumours.
Dmitry I Gabrilovich, Suzanne Ostrand-Rosenberg, Vincenzo Bronte.
Nat Rev Immunol, 2012 Mar 23; 12(4). PMID: 22437938    Free PMC article.
Highly Cited. Review.
m6A-induced lncRNA MALAT1 aggravates renal fibrogenesis in obstructive nephropathy through the miR-145/FAK pathway.
Peihua Liu, Bo Zhang, +4 authors, Xiang Chen.
Aging (Albany NY), 2020 Mar 24; 12(6). PMID: 32203053    Free PMC article.
Targeting focal adhesion kinase in cancer cells and the tumor microenvironment.
James M Murphy, Yelitza A R Rodriguez, +2 authors, Ssang-Taek Steve Lim.
Exp Mol Med, 2020 Jun 10; 52(6). PMID: 32514188    Free PMC article.
Review.
Epigenetic Input Dictates the Threshold of Targeting of the Integrin-Dependent Pathway in Non-small Cell Lung Cancer.
Yang Zhang, Kai Cheng, +12 authors, Xiuwei H Yang.
Front Cell Dev Biol, 2020 Aug 15; 8. PMID: 32793596    Free PMC article.
Fibronectin-containing High-Density Lipoprotein is Associated with Cancer Cell Adhesion and Proliferation.
Eriko Hisamatsu, Manabu Nagao, +7 authors, Ken-Ichi Hirata.
Kobe J Med Sci, 2020 Aug 21; 66(1). PMID: 32814756    Free PMC article.
FAK Signaling in Rhabdomyosarcoma.
Clara Perrone, Silvia Pomella, +4 authors, Rossella Rota.
Int J Mol Sci, 2020 Nov 14; 21(22). PMID: 33182556    Free PMC article.
Review.
Small-Cell Lung Cancer: Is the Black Box Finally Opening Up?
Birgitta I Hiddinga, Klaas Kok.
Cancers (Basel), 2021 Jan 15; 13(2). PMID: 33440615    Free PMC article.
Use of Antiangiogenic Therapies in Pediatric Solid Tumors.
Claudia Ollauri-Ibáñez, Itziar Astigarraga.
Cancers (Basel), 2021 Jan 16; 13(2). PMID: 33445470    Free PMC article.
Review.
High expression of PDGFA predicts poor prognosis of esophageal squamous cell carcinoma.
Na Han, Yan-Yan Zhang, +4 authors, Wen-Chao Zhao.
Medicine (Baltimore), 2021 May 21; 100(20). PMID: 34011067    Free PMC article.