Journal Article
. 2019 Nov; 36(12):2593-2604.
doi: 10.1007/s10815-019-01615-6.

Counseling young women with early breast cancer on fertility preservation

M E Elena Ter Welle-Butalid 1 I J H Ingeborg Vriens 2 J G Josien Derhaag 1 E M Edward Leter 2 C E Christine de Die-Smulders 2 M Marjolein Smidt 2 R J T Ron van Golde 1 V C G Vivianne Tjan-Heijnen 3 
Affiliations
  • PMID: 31760547
  •     101 References
  •     3 citations

Abstract

Purpose: Women with early-stage breast cancer may still have a future child wish, while chemotherapy may impair fertility. To pursue on fertility preservation shortly after breast cancer diagnosis is complex. This review holds a critical reflection on all topics that need to be counseled to give them the opportunity to make a well-informed decision before starting any oncological treatment.

Methods: A comprehensive literature review was performed on papers published in English language on breast cancer in young women, risk of chemotherapy-induced infertility, fertility preservation techniques, impact of possible mutation carriership, and future pregnancy outcome.

Results: Below 40 years of age, the risk of permanent chemotherapy-induced ovarian function failure is approximately 20%, where taxanes do not significantly add to this risk. Overall, 23% of reported women who performed fertility preservation by cryopreserving oocytes or embryos returned for embryo transfer. Of these, 40% gave live birth. Both fertility preservation in women diagnosed with breast cancer and pregnancy after treatment seem safe with respect to breast cancer survival. Women who have a genetic predisposition for breast cancer like BRCA gene mutation should also be informed about the possibility of pre-implantation genetic diagnosis.

Conclusions: Women with an early stage of breast cancer and a possible future child wish should be referred to an expertise center in breast cancer, fertility preservation, and genetics in this complex decision-making process, shortly after diagnosis.

Keywords: Breast cancer; Chemotherapy; Cryopreservation; Fertility preservation; Young women.

Cancer, pregnancy and fertility: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
F A Peccatori, H A Azim, +5 authors, ESMO Guidelines Working Group.
Ann Oncol, 2013 Jul 03; 24 Suppl 6. PMID: 23813932
Highly Cited.
Pierre Robin sequence associated with first trimester fetal tamoxifen exposure.
Joel C Berger, Carol L Clericuzio.
Am J Med Genet A, 2008 Jul 17; 146A(16). PMID: 18629878
Pretreatment anti-Müllerian hormone predicts for loss of ovarian function after chemotherapy for early breast cancer.
Richard A Anderson, Mikkel Rosendahl, Thomas W Kelsey, David A Cameron.
Eur J Cancer, 2013 Aug 24; 49(16). PMID: 23968732    Free PMC article.
Fertility Preservation in Women.
Jacques Donnez, Marie-Madeleine Dolmans.
N Engl J Med, 2017 Oct 27; 377(17). PMID: 29069558
Highly Cited. Review.
Added value of ovarian reserve testing on patient characteristics in the prediction of ovarian response and ongoing pregnancy: an individual patient data approach.
Simone L Broer, Jeroen van Disseldorp, +7 authors, IMPORT study group.
Hum Reprod Update, 2012 Nov 29; 19(1). PMID: 23188168
Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy.
Halle C F Moore, Joseph M Unger, +22 authors, POEMS/S0230 Investigators.
N Engl J Med, 2015 Mar 05; 372(10). PMID: 25738668    Free PMC article.
Highly Cited.
Uptake and outcome of assisted reproductive techniques in long-term survivors of SCT.
A Babb, N Farah, +5 authors, N Salooja.
Bone Marrow Transplant, 2011 Jul 12; 47(4). PMID: 21743501
Incidence of reversible amenorrhea in women with breast cancer undergoing adjuvant anthracycline-based chemotherapy with or without docetaxel.
Martine Berliere, Florence Dalenc, +7 authors, Jean-Pascal Machiels.
BMC Cancer, 2008 Feb 23; 8. PMID: 18291033    Free PMC article.
Ovarian stimulation and emergency in vitro fertilization for fertility preservation in cancer patients.
Nadav Michaan, Gila Ben-David, +6 authors, Foad Azem.
Eur J Obstet Gynecol Reprod Biol, 2010 Jan 16; 149(2). PMID: 20074845
Birth outcome in women with previously treated breast cancer--a population-based cohort study from Sweden.
Kristina Dalberg, Johan Eriksson, Lars Holmberg.
PLoS Med, 2006 Sep 14; 3(9). PMID: 16968117    Free PMC article.
Embryo yield after in vitro fertilization in women undergoing embryo banking for fertility preservation before chemotherapy.
Audra D Robertson, Stacey A Missmer, Elizabeth S Ginsburg.
Fertil Steril, 2010 Jun 15; 95(2). PMID: 20542508
Fertility preservation in women harboring deleterious BRCA mutations: ready for prime time?
Fedro Alessandro Peccatori, Giorgia Mangili, +7 authors, Edgardo Somigliana.
Hum Reprod, 2017 Dec 06; 33(2). PMID: 29207007
The European Society of Breast Cancer Specialists recommendations for the management of young women with breast cancer.
Fatima Cardoso, Sibylle Loibl, +13 authors, European Society of Breast Cancer Specialists.
Eur J Cancer, 2012 Nov 03; 48(18). PMID: 23116682
Changes in markers of ovarian reserve and endocrine function in young women with breast cancer undergoing adjuvant chemotherapy.
Bo Yu, Nataki Douglas, +4 authors, Dawn L Hershman.
Cancer, 2010 Feb 27; 116(9). PMID: 20187091    Free PMC article.
Long-term outcomes in cancer patients who did or did not pursue fertility preservation.
Molly B Moravek, Rafael Confino, +5 authors, Mary Ellen Pavone.
Fertil Steril, 2018 Jan 18; 109(2). PMID: 29338854    Free PMC article.
Pronuclear embryo cryopreservation experience: outcomes for reducing the risk of ovarian hyperstimulation syndrome and for fertility preservation in cancer patients.
Mary E Sabatini, Ann M Wolkovich, +3 authors, Thomas L Toth.
J Assist Reprod Genet, 2010 Nov 26; 28(3). PMID: 21107899    Free PMC article.
Ovarian Stimulation for In Vitro Fertilization and Long-term Risk of Breast Cancer.
Alexandra W van den Belt-Dusebout, Mandy Spaan, +17 authors, Flora E van Leeuwen.
JAMA, 2016 Jul 21; 316(3). PMID: 27434442
Oocyte vitrification versus ovarian cortex transplantation in fertility preservation for adult women undergoing gonadotoxic treatments: a prospective cohort study.
Cesar Diaz-Garcia, Javier Domingo, +6 authors, Antonio Pellicer.
Fertil Steril, 2018 Feb 13; 109(3). PMID: 29428307
Dynamics and mechanisms of chemotherapy-induced ovarian follicular depletion in women of fertile age.
Mikkel Rosendahl, Claus Yding Andersen, +3 authors, Anders Nyboe Andersen.
Fertil Steril, 2009 Apr 04; 94(1). PMID: 19342041
Safety of pregnancy following breast cancer diagnosis: a meta-analysis of 14 studies.
Hatem A Azim, Luigi Santoro, +4 authors, Fedro A Peccatori.
Eur J Cancer, 2010 Oct 15; 47(1). PMID: 20943370
Review.
EUropean REcommendations for female FERtility preservation (EU-REFER): A joint collaboration between oncologists and fertility specialists.
Marie-Madeleine Dolmans, Matteo Lambertini, +7 authors, Ariane Germeyer.
Crit Rev Oncol Hematol, 2019 May 17; 138. PMID: 31092380
Review.
Cancer and fertility preservation: international recommendations from an expert meeting.
Matteo Lambertini, Lucia Del Mastro, +13 authors, Paola Anserini.
BMC Med, 2016 Jan 06; 14. PMID: 26728489    Free PMC article.
Highly Cited.
Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG), R Peto, +15 authors, K Pritchard.
Lancet, 2011 Dec 14; 379(9814). PMID: 22152853    Free PMC article.
Highly Cited.
Twins born after transplantation of ovarian cortical tissue and oocyte vitrification.
María Sánchez-Serrano, Juana Crespo, +4 authors, Antonio Pellicer.
Fertil Steril, 2009 Nov 03; 93(1). PMID: 19880105
Psychological intervention with couples coping with breast cancer: a systematic review.
Tânia Brandão, Marc S Schulz, Paula Mena Matos.
Psychol Health, 2013 Nov 28; 29(5). PMID: 24279379
Systematic Review.
Population-based validation of the prognostic model ADJUVANT! for early breast cancer.
Ivo A Olivotto, Chris D Bajdik, +6 authors, Karen A Gelmon.
J Clin Oncol, 2005 Apr 20; 23(12). PMID: 15837986
Highly Cited.
Endocrine effects of adjuvant letrozole compared with tamoxifen in hormone-responsive postmenopausal patients with early breast cancer: the HOBOE trial.
Emanuela Rossi, Alessandro Morabito, +16 authors, Andrea de Matteis.
J Clin Oncol, 2009 Apr 22; 27(19). PMID: 19380451
The risk of amenorrhea is related to chemotherapy-induced leucopenia in breast cancer patients receiving epirubicin and taxane based chemotherapy.
Wenbin Zhou, Qiang Ding, +4 authors, Shui Wang.
PLoS One, 2012 May 23; 7(5). PMID: 22615953    Free PMC article.
Antimüllerian hormone as a predictor of live birth following assisted reproduction: an analysis of 85,062 fresh and thawed cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012-2013.
Reshef Tal, David B Seifer, +2 authors, Oded Tal.
Fertil Steril, 2018 Jan 15; 109(2). PMID: 29331235
Ovarian Function Recovery During Anastrozole in Breast Cancer Patients With Chemotherapy-Induced Ovarian Function Failure.
Irene E G van Hellemond, Ingeborg J H Vriens, +16 authors, Dutch Breast Cancer Research Group (BOOG).
J Natl Cancer Inst, 2018 Mar 17; 109(12). PMID: 29546343
Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans.
Shiny Titus, Fang Li, +8 authors, Kutluk Oktay.
Sci Transl Med, 2013 Feb 15; 5(172). PMID: 23408054    Free PMC article.
Highly Cited.
Effect of chemotherapy on primordial follicular reserve of rat: an animal model of premature ovarian failure and infertility.
Mehmet Sait Yucebilgin, Mustafa Cosan Terek, +4 authors, Yildiz Erhan.
Aust N Z J Obstet Gynaecol, 2004 Apr 20; 44(1). PMID: 15089860
Frequency of BRCA1/BRCA2 mutations in a population-based sample of young breast carcinoma cases.
K E Malone, J R Daling, +6 authors, E A Ostrander.
Cancer, 2000 Mar 16; 88(6). PMID: 10717622
Ovarian stimulation and in-vitro fertilization outcomes of cancer patients undergoing fertility preservation compared to age matched controls: a 17-year experience.
Eden R Cardozo, Alexcis P Thomson, +3 authors, Mary E Sabatini.
J Assist Reprod Genet, 2015 Jan 18; 32(4). PMID: 25595540    Free PMC article.
Analysis of chemotherapy-induced amenorrhea rates by three different anthracycline and taxane containing regimens for early breast cancer.
Hye-Suk Han, Jungsil Ro, +7 authors, Seok Won Kim.
Breast Cancer Res Treat, 2008 May 29; 115(2). PMID: 18506620
Fertility Preservation Success Subsequent to Concurrent Aromatase Inhibitor Treatment and Ovarian Stimulation in Women With Breast Cancer.
Kutluk Oktay, Volkan Turan, +2 authors, Fred Moy.
J Clin Oncol, 2015 Jun 24; 33(22). PMID: 26101247    Free PMC article.
Risk of cancer after use of fertility drugs with in-vitro fertilisation.
A Venn, L Watson, +2 authors, D Healy.
Lancet, 1999 Nov 24; 354(9190). PMID: 10560672
Longitudinal analysis of psychological adaptation among family members of patients with cancer.
K Ell, R Nishimoto, J Mantell, M Hamovitch.
J Psychosom Res, 1988 Jan 01; 32(4-5). PMID: 3236270
Doxorubicin-induced ovarian toxicity.
Irit Ben-Aharon, Hadas Bar-Joseph, +4 authors, Ruth Shalgi.
Reprod Biol Endocrinol, 2010 Mar 06; 8. PMID: 20202194    Free PMC article.
Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise.
Reza Soleimani, Elke Heytens, Zbigniew Darzynkiewicz, Kutluk Oktay.
Aging (Albany NY), 2011 Aug 27; 3(8). PMID: 21869459    Free PMC article.
Anti-Müllerian hormone in breast cancer patients treated with chemotherapy: a retrospective evaluation of subsequent pregnancies.
Anne-Sophie Hamy, Raphaël Porcher, +10 authors, Marc Espie.
Reprod Biomed Online, 2016 Jan 25; 32(3). PMID: 26803206
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG).
Lancet, 2005 May 17; 365(9472). PMID: 15894097
Highly Cited.
Current evidence supporting fertility and pregnancy among young survivors of breast cancer.
Karen Meneses, Aimee Chism Holland.
J Obstet Gynecol Neonatal Nurs, 2014 Apr 03; 43(3). PMID: 24689363
Review.
The effects of chemotherapy and long-term gonadotrophin suppression on the ovarian reserve in premenopausal women with breast cancer.
R A Anderson, A P N Themmen, +2 authors, D A Cameron.
Hum Reprod, 2006 Jul 06; 21(10). PMID: 16820385
Tamoxifen co-administration during controlled ovarian hyperstimulation for in vitro fertilization in breast cancer patients increases the safety of fertility-preservation treatment strategies.
Dror Meirow, Hila Raanani, +14 authors, Bella Kaufman.
Fertil Steril, 2014 Jun 18; 102(2). PMID: 24934489
The correlation of age with chemotherapy-induced ovarian function failure in breast cancer patients.
Ingeborg J H Vriens, Ashley J R De Bie, +6 authors, Vivianne C G Tjan-Heijnen.
Oncotarget, 2017 Jan 12; 8(7). PMID: 28076330    Free PMC article.
Pregnancy after breast cancer: if you wish, ma'am.
Olivia Pagani, Ann Partridge, +7 authors, North American Breast Cancer Group Endocrine Working Group.
Breast Cancer Res Treat, 2011 Jun 24; 129(2). PMID: 21698406
Review.
Chemotherapy-induced amenorrhea, menopause-specific quality of life, and endocrine profiles in premenopausal women with breast cancer who received adjuvant anthracycline-based chemotherapy: a prospective cohort study.
Changhoon Yoo, Mi Ra Yun, +7 authors, Sung-Bae Kim.
Cancer Chemother Pharmacol, 2013 Jul 12; 72(3). PMID: 23842722
Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update.
Kutluk Oktay, Brittany E Harvey, +6 authors, Alison W Loren.
J Clin Oncol, 2018 Apr 06; 36(19). PMID: 29620997
Highly Cited. Systematic Review.
Fifteen year follow-up of embryos cryopreserved in cancer patients for fertility preservation.
J Barcroft, N Dayoub, K J Thong.
J Assist Reprod Genet, 2013 Jul 10; 30(11). PMID: 23835721    Free PMC article.
Fertility Preservation for the Young Breast Cancer Patient.
Shari B Goldfarb, Sabrina A Kamer, +6 authors, Mary L Gemignani.
Ann Surg Oncol, 2016 Jan 23; 23(5). PMID: 26790670    Free PMC article.
Fertility preservation with ovarian stimulation and time to treatment in women with stage II-III breast cancer receiving neoadjuvant therapy.
A Jo Chien, Julia Chambers, +8 authors, Mitchell P Rosen.
Breast Cancer Res Treat, 2017 May 16; 165(1). PMID: 28503722
Is letrozole needed for controlled ovarian stimulation in patients with estrogen receptor-positive breast cancer?
A Revelli, E Porcu, +3 authors, P Anserini.
Gynecol Endocrinol, 2013 Sep 05; 29(11). PMID: 24000936
Emergency IVF for embryo freezing to preserve female fertility: a French multicentre cohort study.
B Courbiere, C Decanter, +12 authors, French Study Group for Ovarian and Testicular Cryopreservation (GRECOT).
Hum Reprod, 2013 Jul 09; 28(9). PMID: 23832792
IVF for fertility preservation in breast cancer patients--efficacy and safety issues.
M Shapira, H Raanani, D Meirow.
J Assist Reprod Genet, 2015 Jul 02; 32(8). PMID: 26126877    Free PMC article.
Review.
Chemotherapy-induced vascular toxicity--real-time in vivo imaging of vessel impairment.
Hadas Bar-Joseph, Salomon Marcello Stemmer, +2 authors, Irit Ben-Aharon.
J Vis Exp, 2015 Jan 16; (95). PMID: 25590564    Free PMC article.
Comparison of age at natural menopause in BRCA1/2 mutation carriers with a non-clinic-based sample of women in northern California.
Wayne T Lin, Mary Beattie, +5 authors, Mitchell Rosen.
Cancer, 2013 Jan 31; 119(9). PMID: 23362014    Free PMC article.
Web-based survey of fertility issues in young women with breast cancer.
Ann H Partridge, Shari Gelber, +7 authors, Eric P Winer.
J Clin Oncol, 2004 Oct 16; 22(20). PMID: 15483028
Highly Cited.
Incidence, time course, and determinants of menstrual bleeding after breast cancer treatment: a prospective study.
Jeanne A Petrek, Michelle J Naughton, +4 authors, Paniti Sukumvanich.
J Clin Oncol, 2006 Feb 16; 24(7). PMID: 16476708
Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial.
Christina Davies, Hongchao Pan, +36 authors, Adjuvant Tamoxifen: Longer Against Shorter (ATLAS) Collaborative Group.
Lancet, 2012 Dec 12; 381(9869). PMID: 23219286    Free PMC article.
Highly Cited.
Incidence and time course of bleeding after long-term amenorrhea after breast cancer treatment: a prospective study.
Paniti Sukumvanich, L Doug Case, +5 authors, Michelle J Naughton.
Cancer, 2010 Jun 22; 116(13). PMID: 20564648
The effects of paclitaxel, dose density, and trastuzumab on treatment-related amenorrhea in premenopausal women with breast cancer.
Mary E Abusief, Stacey A Missmer, +2 authors, Ann H Partridge.
Cancer, 2010 Jan 07; 116(4). PMID: 20052714
Tamoxifen or letrozole versus standard methods for women with estrogen-receptor positive breast cancer undergoing oocyte or embryo cryopreservation in assisted reproduction.
Taghride Dahhan, Eva Balkenende, +2 authors, Mariëtte Goddijn.
Cochrane Database Syst Rev, 2013 Nov 12; (11). PMID: 24213953
Systematic Review.
Live birth after the transfer of human embryos developed from cryopreserved oocytes harvested before cancer treatment.
Dunsong Yang, Samuel E Brown, +3 authors, Kevin L Winslow.
Fertil Steril, 2007 Apr 10; 87(6). PMID: 17418837
Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression.
Carey K Anders, David S Hsu, +10 authors, Kimberly L Blackwell.
J Clin Oncol, 2008 Jul 10; 26(20). PMID: 18612148
Highly Cited.
Prevalence of preterm, low birthweight, and small for gestational age delivery after breast cancer diagnosis: a population-based study.
Kristin Zeneé Black, Hazel B Nichols, Eugenia Eng, Diane Louise Rowley.
Breast Cancer Res, 2017 Feb 02; 19(1). PMID: 28143580    Free PMC article.
Effect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer: a randomized trial.
Lucia Del Mastro, Luca Boni, +14 authors, Marco Venturini.
JAMA, 2011 Jul 21; 306(3). PMID: 21771987
Delayed childbearing: more women are having their first child later in life.
T J Matthews, Brady E Hamilton.
NCHS Data Brief, 2009 Aug 14; (21). PMID: 19674536
Highly Cited.
Prediction of postchemotherapy ovarian function using markers of ovarian reserve.
N Lynn Henry, Rong Xia, +3 authors, Daniel F Hayes.
Oncologist, 2013 Dec 10; 19(1). PMID: 24319018    Free PMC article.
Increased perinatal mortality and morbidity in monochorionic versus dichorionic twin pregnancies: clinical implications of a large Dutch cohort study.
K E A Hack, J B Derks, +6 authors, G H A Visser.
BJOG, 2007 Nov 15; 115(1). PMID: 17999692
Oocyte vitrification as an efficient option for elective fertility preservation.
Ana Cobo, Juan A García-Velasco, +3 authors, José Remohí.
Fertil Steril, 2015 Dec 22; 105(3). PMID: 26688429
Letrozole reduces estrogen and gonadotropin exposure in women with breast cancer undergoing ovarian stimulation before chemotherapy.
Kutluk Oktay, Ariel Hourvitz, +4 authors, Heejung Bang.
J Clin Endocrinol Metab, 2006 Aug 03; 91(10). PMID: 16882752
Amenorrhea in premenopausal women after adjuvant chemotherapy for breast cancer.
Janice M Walshe, Neelima Denduluri, Sandra M Swain.
J Clin Oncol, 2006 Nov 30; 24(36). PMID: 17130515
Review.
Reproductive choices and outcomes after freezing oocytes for medical reasons: a follow-up study.
T Dahhan, E A F Dancet, +2 authors, M Goddijn.
Hum Reprod, 2014 Jun 22; 29(9). PMID: 24951490
Breast cancer and ovarian tissue cryopreservation: Review of the literature.
Audrey Fleury, Olivier Pirrello, +2 authors, Christelle Linck.
J Gynecol Obstet Hum Reprod, 2018 May 25; 47(8). PMID: 29793036
Review.
Birth outcome in women with breast cancer, cutaneous malignant melanoma, or Hodgkin's disease: a review.
Vivian Langagergaard.
Clin Epidemiol, 2011 Feb 18; 3. PMID: 21326655    Free PMC article.
Ovarian reserve in women who remain premenopausal after chemotherapy for early stage breast cancer.
Ann H Partridge, Kathryn J Ruddy, +4 authors, Elizabeth Ginsburg.
Fertil Steril, 2009 May 05; 94(2). PMID: 19409543
Incidence of chemotherapy-induced amenorrhea in premenopausal patients with breast cancer following adjuvant anthracycline and taxane.
Yuko Okanami, Yoshinori Ito, +5 authors, Kiyohiko Hatake.
Breast Cancer, 2011 Mar 12; 18(3). PMID: 21394515
Concurrent and sequential initiation of ovarian function suppression with chemotherapy in premenopausal women with endocrine-responsive early breast cancer: an exploratory analysis of TEXT and SOFT.
M M Regan, B A Walley, +15 authors, O Pagani.
Ann Oncol, 2017 Sep 16; 28(9). PMID: 28911092    Free PMC article.
Prognostic impact of pregnancy after breast cancer according to estrogen receptor status: a multicenter retrospective study.
Hatem A Azim, Niels Kroman, +12 authors, Fedro A Peccatori.
J Clin Oncol, 2012 Nov 22; 31(1). PMID: 23169515    Free PMC article.
Obstetric outcome after oocyte vitrification and warming for fertility preservation in women with cancer.
Maria Martinez, Susana Rabadan, +3 authors, Juan A Garcia-Velasco.
Reprod Biomed Online, 2014 Dec 03; 29(6). PMID: 25444506
Prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers.
T R Rebbeck.
Eur J Cancer, 2002 Nov 01; 38 Suppl 6. PMID: 12409058
Individualized FSH dosing based on ovarian reserve testing in women starting IVF/ICSI: a multicentre trial and cost-effectiveness analysis.
Theodora C van Tilborg, Simone C Oudshoorn, +14 authors, OPTIMIST study group.
Hum Reprod, 2017 Nov 10; 32(12). PMID: 29121350
BRCA1 mutation carriers have a lower number of mature oocytes after ovarian stimulation for IVF/PGD.
I A P Derks-Smeets, T C van Tilborg, +14 authors, R van Golde.
J Assist Reprod Genet, 2017 Aug 24; 34(11). PMID: 28831696    Free PMC article.
Utilization rates and results of long-term embryo cryopreservation before gonadotoxic treatment.
M M Dolmans, S Hollanders de Ouderaen, D Demylle, C Pirard.
J Assist Reprod Genet, 2015 Jul 16; 32(8). PMID: 26174124    Free PMC article.
A pilot study of predictive markers of chemotherapy-related amenorrhea among premenopausal women with early stage breast cancer.
Carey Anders, P Kelly Marcom, +12 authors, Kimberly Blackwell.
Cancer Invest, 2008 Mar 05; 26(3). PMID: 18317970    Free PMC article.
BRCA Mutations, DNA Repair Deficiency, and Ovarian Aging.
Kutluk Oktay, Volkan Turan, +2 authors, Lin Liu.
Biol Reprod, 2015 Aug 01; 93(3). PMID: 26224004    Free PMC article.
Systematic Review.
Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro fertilisation plus intracytoplasmic sperm injection (IVF/ICSI).
Sarah F Lensen, Jack Wilkinson, +5 authors, Frank J Broekmans.
Cochrane Database Syst Rev, 2018 Feb 02; 2. PMID: 29388198    Free PMC article.
Systematic Review.
American Society of Clinical Oncology recommendations on fertility preservation in cancer patients.
Stephanie J Lee, Leslie R Schover, +7 authors, American Society of Clinical Oncology.
J Clin Oncol, 2006 May 03; 24(18). PMID: 16651642
Highly Cited. Systematic Review.
Transplantation of frozen-thawed ovarian tissue: an update on worldwide activity published in peer-reviewed papers and on the Danish cohort.
S E Gellert, S E Pors, +3 authors, C Yding Andersen.
J Assist Reprod Genet, 2018 Mar 03; 35(4). PMID: 29497953    Free PMC article.
Systematic Review.
Ovarian stimulation for IVF and risk of primary breast cancer in BRCA1/2 mutation carriers.
Inge A P Derks-Smeets, Lieske H Schrijver, +16 authors, Encarna B Gómez García.
Br J Cancer, 2018 Jun 26; 119. PMID: 29937543    Free PMC article.
Pretreatment antimüllerian hormone levels determine rate of posttherapy ovarian reserve recovery: acute changes in ovarian reserve during and after chemotherapy.
Katherine E Dillon, Mary D Sammel, +5 authors, Clarisa R Gracia.
Fertil Steril, 2012 Oct 23; 99(2). PMID: 23084267    Free PMC article.
Reproductive decision-making in young female carriers of a BRCA mutation.
L S Donnelly, M Watson, +5 authors, E Ormondroyd.
Hum Reprod, 2013 Jan 08; 28(4). PMID: 23293217
Final Analysis of the Prevention of Early Menopause Study (POEMS)/SWOG Intergroup S0230.
Halle C F Moore, Joseph M Unger, +22 authors, Kathy S Albain.
J Natl Cancer Inst, 2018 Oct 30; 111(2). PMID: 30371800    Free PMC article.
Predictors of ovarian reserve in young women with breast cancer.
K Lutchman Singh, S Muttukrishna, +6 authors, R Chatterjee.
Br J Cancer, 2007 May 30; 96(12). PMID: 17533402    Free PMC article.
Hereditary breast and ovarian cancer and reproduction: an observational study on the suitability of preimplantation genetic diagnosis for both asymptomatic carriers and breast cancer survivors.
Inge A P Derks-Smeets, Christine E M de Die-Smulders, +12 authors, Willem M Verpoest.
Breast Cancer Res Treat, 2014 Apr 22; 145(3). PMID: 24748567
Survey of Reproductive Experiences and Outcomes of Cancer Survivors Who Stored Reproductive Material Before Treatment.
K Hammarberg, M Kirkman, +7 authors, J R W Fisher.
Hum Reprod, 2017 Oct 19; 32(12). PMID: 29045667
Stimulation of the ovaries in women with breast cancer undergoing fertility preservation: Alternative versus standard stimulation protocols; the study protocol of the STIM-trial.
T Dahhan, E M E Balkenende, +17 authors, M Goddijn.
Contemp Clin Trials, 2017 Jul 16; 61. PMID: 28710053
Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropins in patients with breast cancer: a prospective controlled study.
Amr A Azim, Maria Costantini-Ferrando, Kutluk Oktay.
J Clin Oncol, 2008 May 30; 26(16). PMID: 18509175
Highly Cited.
Five years' experience using oocyte vitrification to preserve fertility for medical and nonmedical indications.
Juan A Garcia-Velasco, Javier Domingo, +3 authors, Antonio Pellicer.
Fertil Steril, 2013 Mar 08; 99(7). PMID: 23465707
The safety and efficacy of controlled ovarian hyperstimulation for fertility preservation in women with early breast cancer: a systematic review.
Rachael J Rodgers, Geoffrey D Reid, +6 authors, Jason A Abbott.
Hum Reprod, 2017 Mar 24; 32(5). PMID: 28333356
Systematic Review.
Breast cancer: an update on treatment-related infertility.
Erica Silvestris, Miriam Dellino, +3 authors, Stella D'Oronzo.
J Cancer Res Clin Oncol, 2020 Feb 02; 146(3). PMID: 32006118
Review.
Preserving fertility in young women undergoing chemotherapy for early breast cancer; the Maastricht experience.
Ingeborg J H Vriens, Elena M Ter Welle-Butalid, +16 authors, Vivianne C G Tjan-Heijnen.
Breast Cancer Res Treat, 2020 Apr 03; 181(1). PMID: 32236826    Free PMC article.
Update on fertility preservation for younger women with breast cancer.
Ellen Warner, Karen Glass, Shu Foong, Emily Sandwith.
CMAJ, 2020 Sep 02; 192(35). PMID: 32868272    Free PMC article.
Review.