Prognostic gene expression profiling in melanoma: necessary steps to incorporate into clinical practice

Douglas Grossman ¹, Caroline C Kim ², Rebecca I Hartman ³, Elizabeth Berry ⁴, Kelly C Nelson ⁵, Nwanneka Okwundu ¹, Clara Curiel-Lewandrowski ⁶, Sancy A Leachman ⁴, Susan M Swetter ⁷

Affiliations

¹ Dermatology, Huntsman Cancer Institute & University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA.
² Dermatology, Tufts Medical Center, Boston & Newton Wellesley Hospital, Wellesley, MA 02111, USA.
³ Dermatology, Brigham & Women's Hospital, Harvard Medical School, & Veterans Affairs Boston Healthcare System, Boston, MA 02446, USA.
⁴ Dermatology, Oregon Health & Sciences University & Knight Cancer Institute, Portland, OR 97239, USA.
⁵ Dermatology, MD Anderson Cancer Center, Houston, TX 77030, USA.
⁶ Dermatology, University of Arizona Cancer Center, Tucson, AZ 85719, USA.
⁷ Dermatology, Stanford University Medical Center & Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94305, USA.

PMID: 31871621
39 References
5 citations

Abstract

Prognostic gene expression profiling (GEP) tests for cutaneous melanoma (CM) are not recommended in current guidelines outside of a clinical trial. However, their use is becoming more prevalent and some practitioners are using GEP tests to guide patient management. Thus, there is an urgent need to bridge this gap between test usage and clinical guideline recommendations by obtaining high-quality evidence to guide us toward best practice use of GEP testing in CM patients. We focus here on the opportunities and uncertainties associated with prognostic GEP testing in CM, review how GEP testing was incorporated into clinical care guidelines for uveal melanoma and breast cancer and discuss the role of clinical trials to determine best use in patients with CM.

Keywords: gene expression profile; melanoma; molecular testing.

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