. 2019 Dec; 2019:7247238.
doi: 10.1155/2019/7247238.

A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease

Qingdong Guan 1 
  • PMID: 31886308
  •     197 References
  •     75 citations


Inflammatory bowel disease (IBD) is a chronic and life-threating inflammatory disease of gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis of IBD is complex. Recent studies have greatly improved our knowledge of the pathophysiology of IBD, leading to great advances in the treatment as well as diagnosis of IBD. In this review, we have systemically reviewed the pathogenesis of IBD and highlighted recent advances in host genetic factors, gut microbiota, and environmental factors and, especially, in abnormal innate and adaptive immune responses and their interactions, which may hold the keys to identify novel predictive or prognostic biomarkers and develop new therapies.

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Sandra Maria Barbalho, Julia Novaes Matias, +7 authors, Ricardo de Alvares Goulart.
Gastroenterology Res, 2021 Mar 20; 14(1). PMID: 33737994    Free PMC article.
Emerging Perspectives of RNA N 6-methyladenosine (m6A) Modification on Immunity and Autoimmune Diseases.
Lipeng Tang, Xingyan Wei, +4 authors, Guangjuan Zheng.
Front Immunol, 2021 Mar 23; 12. PMID: 33746967    Free PMC article.
Nicotinamide Ameliorates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice through Its Anti-Inflammatory Properties and Modulates the Gut Microbiota.
Kai Kang, Yue Sun, +2 authors, Li-Xuan Sang.
J Immunol Res, 2021 Mar 23; 2021. PMID: 33748287    Free PMC article.
The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health.
Clarisse Roblin, Steve Chiumento, +16 authors, Mickael Lafond.
Int J Mol Sci, 2021 Apr 04; 22(6). PMID: 33806791    Free PMC article.
Intestinal Mucosal Wound Healing and Barrier Integrity in IBD-Crosstalk and Trafficking of Cellular Players.
Katrin Sommer, Maximilian Wiendl, +4 authors, Sebastian Zundler.
Front Med (Lausanne), 2021 Apr 10; 8. PMID: 33834033    Free PMC article.
CircRNAs as promising biomarkers of inflammatory bowel disease and its associated-colorectal cancer.
Yuting Xu, Xinwei Xu, +4 authors, Fei Mao.
Am J Transl Res, 2021 Apr 13; 13(3). PMID: 33841681    Free PMC article.
Role of the IL23/IL17 Pathway in Crohn's Disease.
Heike Schmitt, Markus F Neurath, Raja Atreya.
Front Immunol, 2021 Apr 17; 12. PMID: 33859636    Free PMC article.
Prenatal Immunity and Influences on Necrotizing Enterocolitis and Associated Neonatal Disorders.
Maame Efua S Sampah, David J Hackam.
Front Immunol, 2021 May 11; 12. PMID: 33968047    Free PMC article.
Natural-Derived Polysaccharides From Plants, Mushrooms, and Seaweeds for the Treatment of Inflammatory Bowel Disease.
Cailan Li, Guosong Wu, +4 authors, Qiang Lu.
Front Pharmacol, 2021 May 14; 12. PMID: 33981232    Free PMC article.
An MSCT-based radiomics nomogram combined with clinical factors can identify Crohn's disease and ulcerative colitis.
Hui Li, Yan Mo, +5 authors, Xiangshui Meng.
Ann Transl Med, 2021 May 15; 9(7). PMID: 33987270    Free PMC article.
The Relationship between Mucins and Ulcerative Colitis: A Systematic Review.
Esther Bankole, Emily Read, +2 authors, James A Garnett.
J Clin Med, 2021 May 06; 10(9). PMID: 33946184    Free PMC article.
Roles of microRNAs in inflammatory bowel disease.
HyunTaek Jung, Jae Seok Kim, +15 authors, Andreas Kronbichler.
Int J Biol Sci, 2021 Jun 17; 17(8). PMID: 34131410    Free PMC article.
Modeling Gastrointestinal Diseases Using Organoids to Understand Healing and Regenerative Processes.
Alexane Ollivier, Maxime M Mahe, Géraldine Guasch.
Cells, 2021 Jun 03; 10(6). PMID: 34072095    Free PMC article.
Potential Modulatory Microbiome Therapies for Prevention or Treatment of Inflammatory Bowel Diseases.
Daan V Bunt, Adriaan J Minnaard, Sahar El Aidy.
Pharmaceuticals (Basel), 2021 Jun 03; 14(6). PMID: 34073220    Free PMC article.
Current Strategies and Potential Prospects of Nanomedicine-Mediated Therapy in Inflammatory Bowel Disease.
Fengqian Chen, Qi Liu, Yang Xiong, Li Xu.
Int J Nanomedicine, 2021 Jul 01; 16. PMID: 34188471    Free PMC article.
Probiotics, Prebiotics and Synbiotics in Inflammatory Bowel Diseases.
Katarzyna Akutko, Andrzej Stawarski.
J Clin Med, 2021 Jul 03; 10(11). PMID: 34199428    Free PMC article.
Colostrum Therapy for Human Gastrointestinal Health and Disease.
Kanta Chandwe, Paul Kelly.
Nutrients, 2021 Jul 03; 13(6). PMID: 34200282    Free PMC article.
Risk Factors of Venous Thromboembolism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
Hua Zhang, Xuehong Wang.
Front Med (Lausanne), 2021 Jul 16; 8. PMID: 34262920    Free PMC article.
Systematic Review.
Translation and validation of the inflammatory bowel disease fatigue (IBD-F) patient self-assessment questionnaire.
Ariel Liebert, Aleksandra Wileńska, Władysława Czuber-Dochan, Maria Kłopocka.
Prz Gastroenterol, 2021 Jul 20; 16(2). PMID: 34276841    Free PMC article.
Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice.
Paula Marincola Smith, Yash A Choksi, +10 authors, R Daniel Beauchamp.
Am J Physiol Gastrointest Liver Physiol, 2021 Mar 25; 320(6). PMID: 33759564    Free PMC article.
The Role of Cyclophilins in Inflammatory Bowel Disease and Colorectal Cancer.
Lifang Liang, Rongxiao Lin, +4 authors, Hongyuan Chen.
Int J Biol Sci, 2021 Jul 31; 17(10). PMID: 34326693    Free PMC article.
The onset of ulcerative colitis upon Helicobacter pylori eradication in a 72-year-old woman: report of a rare case with a 3-year follow-up.
J Homolak, M Nikolić, +7 authors, D Vražić.
BMC Gastroenterol, 2021 Aug 02; 21(1). PMID: 34332529    Free PMC article.
Fermented and Germinated Processing Improved the Protective Effects of Foxtail Millet Whole Grain Against Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis and Gut Microbiota Dysbiosis in C57BL/6 Mice.
Yuhan Zhang, Wei Liu, +3 authors, Lingfei Li.
Front Nutr, 2021 Aug 17; 8. PMID: 34395495    Free PMC article.
Bortezomib: a proteasome inhibitor for the treatment of autoimmune diseases.
Naeemeh Khalesi, Shahla Korani, +2 authors, Amirhossein Sahebkar.
Inflammopharmacology, 2021 Aug 24; 29(5). PMID: 34424482
Translating Treg Therapy for Inflammatory Bowel Disease in Humanized Mice.
Sushmita Negi, Sheetal Saini, +3 authors, Rajeev K Tyagi.
Cells, 2021 Aug 28; 10(8). PMID: 34440615    Free PMC article.
Comparative Transcriptomic Analysis Reveals the Immunosuppressive Targets of Mesalazine in Dextran Sulfate Sodium-Induced Ulcerative Colitis.
Rong Li, Lin Cheng, Qi Wang, Liming Zhou.
Front Genet, 2021 Aug 31; 12. PMID: 34456974    Free PMC article.
Glycosylation in Autoimmune Diseases.
Marta Ząbczyńska, Paweł Link-Lenczowski, Ewa Pocheć.
Adv Exp Med Biol, 2021 Sep 09; 1325. PMID: 34495537
Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel diseases: A review.
Tilemachos Koutouratsas, Anastassios Philippou, +2 authors, Maria Gazouli.
World J Gastroenterol, 2021 Sep 10; 27(30). PMID: 34497433    Free PMC article.
Crohn's Disease Susceptibility and Onset Are Strongly Related to Three NOD2 Gene Haplotypes.
Marta Kaczmarek-Ryś, Szymon Tytus Hryhorowicz, +12 authors, Andrzej Pławski.
J Clin Med, 2021 Sep 11; 10(17). PMID: 34501225    Free PMC article.
Transcriptomic and Proteomic Study on the High-Fat Diet Combined With AOM/DSS-Induced Adenomatous Polyps in Mice.
Cui Guo, Yimin Xu, +4 authors, Xiaoling Fu.
Front Oncol, 2021 Sep 14; 11. PMID: 34513713    Free PMC article.
In vivo visualization and characterization of inflamed intestinal wall: the exploration of targeted microbubbles in assessing NF-κB expression.
Chenyang Zhao, Li Ma, +4 authors, Yuxin Jiang.
J Cell Mol Med, 2021 Aug 20; 25(18). PMID: 34409723    Free PMC article.
C3435T Polymorphism of the ABCB1 Gene in Polish Patients with Inflammatory Bowel Disease: A Case-Control and Meta-Analysis Study.
Paweł Petryszyn, Robert Dudkowiak, +5 authors, Krystyna Głowacka.
Genes (Basel), 2021 Sep 29; 12(9). PMID: 34573401    Free PMC article.
Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies.
Peng Liu, Caifang Gao, +5 authors, Yitao Wang.
Acta Pharm Sin B, 2021 Oct 01; 11(9). PMID: 34589398    Free PMC article.
Tumor Necrosis Factor's Pathway in Crohn's Disease: Potential for Intervention.
Cristiano Pagnini, Fabio Cominelli.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34638616    Free PMC article.
Effects of Wine Components in Inflammatory Bowel Diseases.
Josip Vrdoljak, Marko Kumric, +4 authors, Josko Bozic.
Molecules, 2021 Oct 14; 26(19). PMID: 34641434    Free PMC article.
Ding's herbal enema treats dextran sulfate sodium-induced colitis in mice by regulating the gut microbiota and maintaining the Treg/Th17 cell balance.
Yan-Yan Tan, Yang Ding, +14 authors, Yi-Jiang Ding.
Exp Ther Med, 2021 Oct 19; 22(6). PMID: 34659514    Free PMC article.
Role of Digital Health and Artificial Intelligence in Inflammatory Bowel Disease: A Scoping Review.
Kamila Majidova, Julia Handfield, +2 authors, Ryszard Kubinski.
Genes (Basel), 2021 Oct 24; 12(10). PMID: 34680860    Free PMC article.
Emerging roles of the Hedgehog signalling pathway in inflammatory bowel disease.
Zhuo Xie, Mudan Zhang, +8 authors, Shenghong Zhang.
Cell Death Discov, 2021 Oct 28; 7(1). PMID: 34702800    Free PMC article.
[What is confirmed in the treatment of chronic inflammatory bowel diseases].
Carolin F Manthey, Dominik Reher, Samuel Huber.
Internist (Berl), 2021 Nov 03;. PMID: 34727190    Free PMC article.
Magnetic resonance colonography assessment of acute trinitrobenzene sulfonic acid colitis in pre-pubertal rats.
Claire Dupont-Lucas, Rachel Marion-Letellier, +8 authors, Guillaume Savoye.
PLoS One, 2021 Nov 05; 16(11). PMID: 34735489    Free PMC article.
Gut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel disease.
Manasvini Markandey, Aditya Bajaj, +4 authors, Vineet Ahuja.
Gut Microbes, 2021 Nov 09; 13(1). PMID: 34747326    Free PMC article.
Efficacy of a Preparation Based on Calcium Butyrate, Bifidobacterium bifidum, Bifidobacterium lactis, and Fructooligosaccharides in the Prevention of Relapse in Ulcerative Colitis: A Prospective Observational Study.
Gian Paolo Caviglia, Federico De Blasio, +6 authors, Davide Giuseppe Ribaldone.
J Clin Med, 2021 Nov 14; 10(21). PMID: 34768480    Free PMC article.
Risk Factors for Malnutrition among IBD Patients.
Larisa Einav, Ayal Hirsch, +6 authors, Naomi Fliss-Isakov.
Nutrients, 2021 Nov 28; 13(11). PMID: 34836353    Free PMC article.
Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease.
Yongyan Chen, Wenwen Cui, Xiao Li, Huan Yang.
Front Immunol, 2021 Dec 04; 12. PMID: 34858414    Free PMC article.