Journal Article
. 2020 Feb;52(3).
doi: 10.4143/crt.2019.387.

Comparison of the Distribution Pattern of 21-Gene Recurrence Score between Mucinous Breast Cancer and Infiltrating Ductal Carcinoma in Chinese Population: A Retrospective Single-Center Study

Jiayi Wu 1 Shuning Ding 1 Lin Lin 2 Xiaochun Fei 3 Caijin Lin 1 Lisa Andriani 1 Chihwan Goh 1 Jiahui Huang 1 Jin Hong 1 Weiqi Gao 1 Siji Zhu 1 Hui Wang 1 Ou Huang 1 Xiaosong Chen 1 Jianrong He 1 Yafen Li 1 Kunwei Shen 1 Weiguo Chen 1 Li Zhu 1 
  • PMID: 32019280
  •     22 References
  •     1 citations


Purpose: This retrospective study aimed to evaluate the distribution pattern and prognostic value of 21-gene recurrence score (RS) in Chinese patients with mucinous breast cancer (MC) and compared with infiltrating ductal carcinoma (IDC).

Materials And Methods: Patients diagnosed with MC or IDC from January 2010 to January 2017 were retrospectively recruited. Reverse transcriptase-polymerase chain reaction assay of 21 genes was conducted to calculate the RS. Univariate and multivariate analyses were performed to assess the association between RS and clinicopathological factors. Survival outcomes including disease-free survival (DFS) and overall survival (OS) were estimated by Kaplan-Meier method and compared by log-rank test.

Results: The MC cohort included 128 patients and the IDC cohort included 707 patients. The proportions of patients with a low (RS < 18), intermediate (18-30), or high risk (RS > 30) were 32.0%, 48.4%, and 19.5% in MC cohort, and 26.9%, 46.8% and 26.3% in IDC cohort. The distribution of RS varied significantly according to different Ki-67 index and molecular subtype in both cohorts. Moreover, the receipt of chemotherapy was associated with RS in both cohorts. Among patients with MC, tumor stage was related to the DFS (p=0.040). No significant differences in DFS and OS were found among MC patients in different RS risk groups (OS, p=0.695; DFS, p=0.926).

Conclusion: RS was significantly related to Ki-67 index and molecular subtypes in MC patients, which is similar in IDC patients. However, RS was not able to predict DFS and OS in patients with MC.

Keywords: Mucinous mammary malignancy; Multigene assay; Prognosis.

Distribution patterns of 21-gene recurrence score in 980 Chinese estrogen receptor-positive, HER2-negative early breast cancer patients.
Jiayi Wu, Yan Fang, +11 authors, Kunwei Shen.
Oncotarget, 2017 Apr 14; 8(24). PMID: 28404972    Free PMC article.
Surgery time interval and molecular subtype may influence Ki67 change after core needle biopsy in breast cancer patients.
Xiaosong Chen, Siji Zhu, +9 authors, Kunwei Shen.
BMC Cancer, 2015 Oct 31; 15. PMID: 26514283    Free PMC article.
Clinicopathologic characteristics of mucinous carcinoma of the breast.
Takeshi Hanagiri, Kenji Ono, +6 authors, Kosei Yasumoto.
Int Surg, 2010 Aug 20; 95(2). PMID: 20718318
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.
Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
Highly Cited.
Mucinous carcinoma of the breast: a pathologic study of 82 cases.
S André, F Cunha, +3 authors, J Soares.
J Surg Oncol, 1995 Mar 01; 58(3). PMID: 7898111
Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen: a TransATAC study.
Mitch Dowsett, Jack Cuzick, +11 authors, Steven Shak.
J Clin Oncol, 2010 Mar 10; 28(11). PMID: 20212256
Highly Cited.
Mucinous carcinoma of the breast in Japan. A prognostic analysis based on morphologic features.
K Komaki, G Sakamoto, +2 authors, Y Monden.
Cancer, 1988 Mar 01; 61(5). PMID: 2827884
Distribution of 21-Gene Recurrence Scores Among Breast Cancer Histologic Subtypes.
Scott Kizy, Jing Li Huang, +5 authors, Jane Yuet Ching Hui.
Arch Pathol Lab Med, 2018 Mar 13; 142(6). PMID: 29528718
Progesterone receptor status and Ki-67 index may predict early relapse in luminal B/HER2 negative breast cancer patients: a retrospective study.
Yu Zong, Li Zhu, +7 authors, Kunwei Shen.
PLoS One, 2014 Aug 30; 9(8). PMID: 25170613    Free PMC article.
A retrospective review with long term follow up of 11,400 cases of pure mucinous breast carcinoma.
Salomone Di Saverio, Juan Gutierrez, Eli Avisar.
Breast Cancer Res Treat, 2007 Nov 21; 111(3). PMID: 18026874
Uncommon breast tumors in perspective: incidence, treatment and survival in the Netherlands.
Marieke W J Louwman, Martine Vriezen, +5 authors, Jan Willem W Coebergh.
Int J Cancer, 2007 Mar 03; 121(1). PMID: 17330844
Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial.
Kathy S Albain, William E Barlow, +20 authors, Breast Cancer Intergroup of North America.
Lancet Oncol, 2009 Dec 17; 11(1). PMID: 20005174    Free PMC article.
Highly Cited.
American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.
M Elizabeth H Hammond, Daniel F Hayes, +29 authors, Antonio C Wolff.
J Clin Oncol, 2010 Apr 21; 28(16). PMID: 20404251    Free PMC article.
Highly Cited. Systematic Review.
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.
Soonmyung Paik, Steven Shak, +12 authors, Norman Wolmark.
N Engl J Med, 2004 Dec 14; 351(27). PMID: 15591335
Highly Cited.
Mucinous breast carcinoma: a large contemporary series.
Christina R Barkley, Jennifer A Ligibel, +3 authors, Mehra Golshan.
Am J Surg, 2008 Sep 24; 196(4). PMID: 18809061
Distribution and Clinical Utility of the 21-gene Recurrence Score in Pure Mucinous Breast Cancer Patients: a case-control study.
Wei Wang, Xiaosong Chen, +12 authors, Kunwei Shen.
J Cancer, 2018 Oct 03; 9(18). PMID: 30271480    Free PMC article.
Mucinous carcinoma of the breast in comparison with invasive ductal carcinoma: clinicopathologic characteristics and prognosis.
Soo Youn Bae, Min-Young Choi, +3 authors, Jung-Hyun Yang.
J Breast Cancer, 2012 Feb 11; 14(4). PMID: 22323918    Free PMC article.
West German Study Group Phase III PlanB Trial: First Prospective Outcome Data for the 21-Gene Recurrence Score Assay and Concordance of Prognostic Markers by Central and Local Pathology Assessment.
Oleg Gluz, Ulrike A Nitz, +18 authors, Nadia Harbeck.
J Clin Oncol, 2016 Mar 02; 34(20). PMID: 26926676
Highly Cited.
Tumor characteristics and clinical outcome of tubular and mucinous breast carcinomas.
S G Diab, G M Clark, +3 authors, R M Elledge.
J Clin Oncol, 1999 May 20; 17(5). PMID: 10334529
Clinical characteristics of different histologic types of breast cancer.
C I Li, D J Uribe, J R Daling.
Br J Cancer, 2005 Sep 22; 93(9). PMID: 16175185    Free PMC article.
Highly Cited.
Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified.
Seho Park, Jaseung Koo, +3 authors, Kyong Sik Lee.
J Korean Med Sci, 2010 Mar 02; 25(3). PMID: 20191033    Free PMC article.
Clinicopathological evaluation of 100 cases of mucinous carcinoma of breast with emphasis on axillary staging and special reference to a micropapillary pattern.
Aditi Ranade, Rashmi Batra, +2 authors, Jasminka Balderacchi.
J Clin Pathol, 2010 Oct 22; 63(12). PMID: 20962055
Concordance of the 21-gene assay between core needle biopsy and resection specimens in early breast cancer patients.
Peng Qi, Yu Yang, +5 authors, Xiao-Yan Zhou.
Breast Cancer Res Treat, 2021 Jan 14;. PMID: 33439420    Free PMC article.