. 2020 Feb; 20(9):566-578.
doi: 10.1038/s41577-020-0281-x.

Lymphatic endothelial cells of the lymph node

Sirpa Jalkanen 1 Marko Salmi 2 
  • PMID: 32094869
  •     162 References
  •     10 citations


The influx and efflux of cells and antigens to and from the draining lymph nodes largely take place through the subcapsular, cortical and medullary sinus systems. Recent analyses in mice and humans have revealed unexpected diversity in the lymphatic endothelial cells, which form the distinct regions of the sinuses. As a semipermeable barrier, the lymphatic endothelial cells regulate the sorting of lymph-borne antigens to the lymph node parenchyma and can themselves serve as antigen-presenting cells. The leukocytes entering the lymph node via the sinus system and the lymphocytes egressing from the parenchyma migrate through the lymphatic endothelial cell layer. The sinus lymphatic endothelial cells also orchestrate the organogenesis of lymph nodes, and they undergo bidirectional signalling with other sinus-resident cells, such as subcapsular sinus macrophages, to generate a unique lymphatic niche. In this Review, we consider the structural and functional basis of how the lymph node sinus system coordinates immune responses under physiological conditions, and in inflammation and cancer.

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Immunity, 2019 May 06; 50(6). PMID: 31053503    Free PMC article.
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Immunity, 2019 Jun 16; 50(6). PMID: 31201093
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J Immunol, 2014 Jul 13; 193(4). PMID: 25015824
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Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis.
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Myeloid-Derived Lymphatic Endothelial Cell Progenitors Significantly Contribute to Lymphatic Metastasis in Clinical Breast Cancer.
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Transcellular Pathways in Lymphatic Endothelial Cells Regulate Changes in Solute Transport by Fluid Stress.
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New tools to prevent cancer growth and spread: a 'Clever' approach.
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The Gut-Lung Axis in Systemic Inflammation. Role of Mesenteric Lymph as a Conduit.
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Afferent Lymphatic Transport and Peripheral Tissue Immunity.
Maria M Steele, Amanda W Lund.
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The evolving cardiac lymphatic vasculature in development, repair and regeneration.
Konstantinos Klaourakis, Joaquim M Vieira, Paul R Riley.
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Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery.
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Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing.
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Lymphatic Endothelial Cell Activation and Dendritic Cell Transmigration Is Modified by Genetic Deletion of Clever-1.
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Lymphocyte egress signal sphingosine-1-phosphate promotes ERM-guided, bleb-based migration.
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The metabolism-modulating activity of IL-17 signaling in health and disease.
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