Review
. 2020 Feb; 20(9):566-578.
doi: 10.1038/s41577-020-0281-x.

Lymphatic endothelial cells of the lymph node

Sirpa Jalkanen 1 Marko Salmi 2 
Affiliations
  • PMID: 32094869
  •     162 References
  •     10 citations

Abstract

The influx and efflux of cells and antigens to and from the draining lymph nodes largely take place through the subcapsular, cortical and medullary sinus systems. Recent analyses in mice and humans have revealed unexpected diversity in the lymphatic endothelial cells, which form the distinct regions of the sinuses. As a semipermeable barrier, the lymphatic endothelial cells regulate the sorting of lymph-borne antigens to the lymph node parenchyma and can themselves serve as antigen-presenting cells. The leukocytes entering the lymph node via the sinus system and the lymphocytes egressing from the parenchyma migrate through the lymphatic endothelial cell layer. The sinus lymphatic endothelial cells also orchestrate the organogenesis of lymph nodes, and they undergo bidirectional signalling with other sinus-resident cells, such as subcapsular sinus macrophages, to generate a unique lymphatic niche. In this Review, we consider the structural and functional basis of how the lymph node sinus system coordinates immune responses under physiological conditions, and in inflammation and cancer.

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Myeloid-Derived Lymphatic Endothelial Cell Progenitors Significantly Contribute to Lymphatic Metastasis in Clinical Breast Cancer.
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The lymphatic vasculature revisited.
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The evolving cardiac lymphatic vasculature in development, repair and regeneration.
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Lymphatic Endothelial Cell Activation and Dendritic Cell Transmigration Is Modified by Genetic Deletion of Clever-1.
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Front Immunol, 2021 Mar 23; 12. PMID: 33746947    Free PMC article.
Lymphocyte egress signal sphingosine-1-phosphate promotes ERM-guided, bleb-based migration.
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