. 2020 Mar; 21(5):.
doi: 10.3390/ijms21051594.

Determinants of Resistance to Checkpoint Inhibitors

Linda Tran 1 Dan Theodorescu 1 
  • PMID: 32111080
  •     195 References
  •     13 citations


The development of immune checkpoint inhibitors (ICIs) has drastically altered the landscape of cancer treatment. Since approval of the first ICI for the treatment of advanced melanoma in 2011, several therapeutic agents have been Food and Drug Administration (FDA)-approved for multiple cancers, and hundreds of clinical trials are currently ongoing. These antibodies disrupt T-cell inhibitory pathways established by tumor cells and thus re-activate the host's antitumor immune response. While successful in many cancers, several types remain relatively refractory to treatment or patients develop early recurrence. Hence, there is a great need to further elucidate mechanisms of resistant disease and determine novel, effective, and tolerable combination therapies to enhance efficacy of ICIs.

Keywords: cancer; combination therapy; functional genomics; immune checkpoint inhibitors; immune checkpoints; immunotherapy; next generation sequencing; predictive markers; prognostic markers.

Adoptive cellular therapy: a race to the finish line.
Carl H June, Stanley R Riddell, Ton N Schumacher.
Sci Transl Med, 2015 Mar 27; 7(280). PMID: 25810311
Highly Cited. Review.
Combining Immunotherapy and Radiotherapy for Cancer Treatment: Current Challenges and Future Directions.
Yifan Wang, Weiye Deng, +4 authors, Steven H Lin.
Front Pharmacol, 2018 Mar 21; 9. PMID: 29556198    Free PMC article.
Highly Cited. Review.
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy.
Padmanee Sharma, Siwen Hu-Lieskovan, Jennifer A Wargo, Antoni Ribas.
Cell, 2017 Feb 12; 168(4). PMID: 28187290    Free PMC article.
Highly Cited. Review.
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.
Sanjeev Mariathasan, Shannon J Turley, +39 authors, Thomas Powles.
Nature, 2018 Feb 15; 554(7693). PMID: 29443960    Free PMC article.
Highly Cited.
Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength.
Jackson G Egen, James P Allison.
Immunity, 2002 Feb 05; 16(1). PMID: 11825563
Highly Cited.
Improved Efficacy of Neoadjuvant Compared to Adjuvant Immunotherapy to Eradicate Metastatic Disease.
Jing Liu, Stephen J Blake, +8 authors, Michele W L Teng.
Cancer Discov, 2016 Sep 25; 6(12). PMID: 27663893
Highly Cited.
T lymphocyte subsets in cancer immunity: Friends or foes.
Dounia Chraa, Asmaa Naim, Daniel Olive, Abdallah Badou.
J Leukoc Biol, 2018 Nov 06; 105(2). PMID: 30387907
Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer.
Dung T Le, Eric Lutz, +8 authors, Daniel A Laheru.
J Immunother, 2013 Aug 09; 36(7). PMID: 23924790    Free PMC article.
Highly Cited.
Calreticulin exposure dictates the immunogenicity of cancer cell death.
Michel Obeid, Antoine Tesniere, +14 authors, Guido Kroemer.
Nat Med, 2006 Dec 26; 13(1). PMID: 17187072
Highly Cited.
Genetic basis for clinical response to CTLA-4 blockade in melanoma.
Alexandra Snyder, Vladimir Makarov, +18 authors, Timothy A Chan.
N Engl J Med, 2014 Nov 20; 371(23). PMID: 25409260    Free PMC article.
Highly Cited.
Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas.
Jing Zeng, Alfred P See, +18 authors, Michael Lim.
Int J Radiat Oncol Biol Phys, 2013 Mar 07; 86(2). PMID: 23462419    Free PMC article.
Highly Cited.
Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy.
Jonathan Pol, Erika Vacchelli, +11 authors, Lorenzo Galluzzi.
Oncoimmunology, 2015 Jul 03; 4(4). PMID: 26137404    Free PMC article.
Highly Cited. Review.
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens.
Matthew M Gubin, Xiuli Zhang, +24 authors, Robert D Schreiber.
Nature, 2014 Nov 28; 515(7528). PMID: 25428507    Free PMC article.
Highly Cited.
Durvalumab after Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer.
Scott J Antonia, Augusto Villegas, +28 authors, PACIFIC Investigators.
N Engl J Med, 2017 Sep 09; 377(20). PMID: 28885881
Highly Cited.
Intratumoral regulatory T cells: markers, subsets and their impact on anti-tumor immunity.
Hiroshi Yano, Lawrence P Andrews, Creg J Workman, Dario A A Vignali.
Immunology, 2019 May 16; 157(3). PMID: 31087644    Free PMC article.
Highly Cited. Review.
Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer.
Scott Gettinger, Jungmin Choi, +23 authors, Katerina Politi.
Cancer Discov, 2017 Oct 14; 7(12). PMID: 29025772    Free PMC article.
Highly Cited.
Evaluation of safety and efficacy of p53MVA vaccine combined with pembrolizumab in patients with advanced solid cancers.
V Chung, F J Kos, +8 authors, D J Diamond.
Clin Transl Oncol, 2018 Aug 11; 21(3). PMID: 30094792    Free PMC article.
Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.
A A Hurwitz, B A Foster, +5 authors, J P Allison.
Cancer Res, 2000 May 16; 60(9). PMID: 10811122
Highly Cited.
Immune checkpoint inhibitors: recent progress and potential biomarkers.
Pramod Darvin, Salman M Toor, Varun Sasidharan Nair, Eyad Elkord.
Exp Mol Med, 2018 Dec 14; 50(12). PMID: 30546008    Free PMC article.
Highly Cited. Review.
IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade.
Mark Ayers, Jared Lunceford, +12 authors, Terrill K McClanahan.
J Clin Invest, 2017 Jun 27; 127(8). PMID: 28650338    Free PMC article.
Highly Cited.
Expansion of tumor-infiltrating lymphocytes and their potential for application as adoptive cell transfer therapy in human breast cancer.
Hee Jin Lee, Young-Ae Kim, +16 authors, Gyungyub Gong.
Oncotarget, 2018 Jan 27; 8(69). PMID: 29371915    Free PMC article.
A Pilot Study of Anti-CTLA4 Antibody Ipilimumab in Patients with Synovial Sarcoma.
Robert G Maki, Achim A Jungbluth, +11 authors, Gerd Ritter.
Sarcoma, 2013 Apr 05; 2013. PMID: 23554566    Free PMC article.
Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study.
Matthew D Hellmann, Naiyer A Rizvi, +14 authors, Scott J Antonia.
Lancet Oncol, 2016 Dec 10; 18(1). PMID: 27932067    Free PMC article.
Highly Cited.
Chemotherapeutic agent-mediated elimination of myeloid-derived suppressor cells.
Zibing Wang, Brian Till, Quanli Gao.
Oncoimmunology, 2017 Aug 16; 6(7). PMID: 28811975    Free PMC article.
EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non-Small Cell Lung Cancer: A Retrospective Analysis.
Justin F Gainor, Alice T Shaw, +18 authors, Mari Mino-Kenudson.
Clin Cancer Res, 2016 May 27; 22(18). PMID: 27225694    Free PMC article.
Highly Cited.
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.
Naiyer A Rizvi, Matthew D Hellmann, +21 authors, Timothy A Chan.
Science, 2015 Mar 15; 348(6230). PMID: 25765070    Free PMC article.
Highly Cited.
Immunogenic effects of chemotherapy-induced tumor cell death.
Yi-Jun Wang, Rochelle Fletcher, Jian Yu, Lin Zhang.
Genes Dis, 2018 Oct 16; 5(3). PMID: 30320184    Free PMC article.
Highly Cited. Review.
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.
Sydney R Gordon, Roy L Maute, +10 authors, Irving L Weissman.
Nature, 2017 May 18; 545(7655). PMID: 28514441    Free PMC article.
Highly Cited.
Entinostat Neutralizes Myeloid-Derived Suppressor Cells and Enhances the Antitumor Effect of PD-1 Inhibition in Murine Models of Lung and Renal Cell Carcinoma.
Ashley Orillion, Ayumi Hashimoto, +9 authors, Roberto Pili.
Clin Cancer Res, 2017 Jul 13; 23(17). PMID: 28698201    Free PMC article.
Highly Cited.
Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers.
Daniel J McGrail, Lorenzo Federico, +6 authors, Nidhi Sahni.
Nat Commun, 2018 Apr 05; 9(1). PMID: 29615613    Free PMC article.
Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance.
Nune Markosyan, Edward P Chen, Emer M Smyth.
Oncoimmunology, 2014 Aug 13; 3. PMID: 25114833    Free PMC article.
CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.
Yu Zhu, Brett L Knolhoff, +7 authors, David G DeNardo.
Cancer Res, 2014 Aug 02; 74(18). PMID: 25082815    Free PMC article.
Highly Cited.
CD4/major histocompatibility complex class II interaction analyzed with CD4- and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins.
B Huard, P Prigent, +2 authors, F Triebel.
Eur J Immunol, 1995 Sep 01; 25(9). PMID: 7589152
STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.
Shohei Koyama, Esra A Akbay, +30 authors, Kwok-Kin Wong.
Cancer Res, 2016 Feb 03; 76(5). PMID: 26833127    Free PMC article.
Highly Cited.
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma.
Eliezer M Van Allen, Diana Miao, +19 authors, Levi A Garraway.
Science, 2015 Sep 12; 350(6257). PMID: 26359337    Free PMC article.
Highly Cited.
Resistance to checkpoint blockade therapy through inactivation of antigen presentation.
Moshe Sade-Feldman, Yunxin J Jiao, +28 authors, Nir Hacohen.
Nat Commun, 2017 Oct 27; 8(1). PMID: 29070816    Free PMC article.
Highly Cited.
Establishment of adoptive cell therapy with tumor infiltrating lymphocytes for non-small cell lung cancer patients.
Ronny Ben-Avi, Ronit Farhi, +6 authors, Michal J Besser.
Cancer Immunol Immunother, 2018 May 31; 67(8). PMID: 29845338
The IPD and IMGT/HLA database: allele variant databases.
James Robinson, Jason A Halliwell, +3 authors, Steven G E Marsh.
Nucleic Acids Res, 2014 Nov 22; 43(Database issue). PMID: 25414341    Free PMC article.
Highly Cited.
Cancer immunoediting: from immunosurveillance to tumor escape.
Gavin P Dunn, Allen T Bruce, +2 authors, Robert D Schreiber.
Nat Immunol, 2002 Oct 31; 3(11). PMID: 12407406
Highly Cited. Review.
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome.
Jérôme Galon, Anne Costes, +13 authors, Franck Pagès.
Science, 2006 Sep 30; 313(5795). PMID: 17008531
Highly Cited.
Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy.
Megan M Tu, Francis Y F Lee, +20 authors, Dan Theodorescu.
Sci Adv, 2019 Feb 26; 5(2). PMID: 30801016    Free PMC article.
Anti-PD-1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases.
Pooja Dhupkar, Nancy Gordon, John Stewart, Eugenie S Kleinerman.
Cancer Med, 2018 May 08; 7(6). PMID: 29733528    Free PMC article.
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial.
Jonathan E Rosenberg, Jean Hoffman-Censits, +28 authors, Robert Dreicer.
Lancet, 2016 Mar 10; 387(10031). PMID: 26952546    Free PMC article.
Highly Cited.
Modulation of GITR for cancer immunotherapy.
David A Schaer, Judith T Murphy, Jedd D Wolchok.
Curr Opin Immunol, 2012 Jan 17; 24(2). PMID: 22245556    Free PMC article.
Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies.
Géraldine Genard, Stéphane Lucas, Carine Michiels.
Front Immunol, 2017 Aug 05; 8. PMID: 28769933    Free PMC article.
Highly Cited. Review.
Pembrolizumab for Treatment-Refractory Metastatic Castration-Resistant Prostate Cancer: Multicohort, Open-Label Phase II KEYNOTE-199 Study.
Emmanuel S Antonarakis, Josep M Piulats, +21 authors, Johann Sebastian de Bono.
J Clin Oncol, 2019 Nov 28; 38(5). PMID: 31774688    Free PMC article.
Improved survival with ipilimumab in patients with metastatic melanoma.
F Stephen Hodi, Steven J O'Day, +26 authors, Walter J Urba.
N Engl J Med, 2010 Jun 08; 363(8). PMID: 20525992    Free PMC article.
Highly Cited.
Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation.
A van Elsas, A A Hurwitz, J P Allison.
J Exp Med, 1999 Aug 03; 190(3). PMID: 10430624    Free PMC article.
Highly Cited.
A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system.
Martin W LaFleur, Thao H Nguyen, +9 authors, Arlene H Sharpe.
Nat Commun, 2019 Apr 12; 10(1). PMID: 30971695    Free PMC article.
Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials.
Sandra P D'Angelo, Michelle R Mahoney, +8 authors, Howard Streicher.
Lancet Oncol, 2018 Jan 27; 19(3). PMID: 29370992    Free PMC article.
Highly Cited.
Chemotherapeutic targeting of cancer-induced immunosuppressive cells.
Darya Alizadeh, Nicolas Larmonier.
Cancer Res, 2014 Apr 30; 74(10). PMID: 24778417    Free PMC article.
Highly Cited. Review.
Chemotherapy in Combination With Immune Checkpoint Inhibitors for the First-Line Treatment of Patients With Advanced Non-small Cell Lung Cancer: A Systematic Review and Literature-Based Meta-Analysis.
Alfredo Addeo, Giuseppe Luigi Banna, Giulio Metro, Massimo Di Maio.
Front Oncol, 2019 May 07; 9. PMID: 31058078    Free PMC article.
Highly Cited. Systematic Review.
Compression of functional space in HLA-A sequence diversity.
Bing Zhao, Adrian Eak H Png, +4 authors, Pandjassarame Kangueane.
Hum Immunol, 2003 Jun 27; 64(7). PMID: 12826374
Preventing postoperative metastatic disease by inhibiting surgery-induced dysfunction in natural killer cells.
Lee-Hwa Tai, Christiano Tanese de Souza, +12 authors, Rebecca A Auer.
Cancer Res, 2012 Oct 24; 73(1). PMID: 23090117
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.
Dung T Le, Jennifer N Uram, +32 authors, Luis A Diaz.
N Engl J Med, 2015 Jun 02; 372(26). PMID: 26028255    Free PMC article.
Highly Cited.
Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial.
Leonie Voorwerk, Maarten Slagter, +31 authors, Marleen Kok.
Nat Med, 2019 May 16; 25(6). PMID: 31086347
Highly Cited.
Neoadjuvant PD-1 Blockade in Resectable Lung Cancer.
Patrick M Forde, Jamie E Chaft, +32 authors, Drew M Pardoll.
N Engl J Med, 2018 Apr 17; 378(21). PMID: 29658848    Free PMC article.
Highly Cited.
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade.
Spencer C Wei, Jacob H Levine, +8 authors, James P Allison.
Cell, 2017 Aug 15; 170(6). PMID: 28803728    Free PMC article.
Highly Cited.
Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma: A Phase 2 Randomized Clinical Trial.
Eileen M O'Reilly, Do-Youn Oh, +11 authors, Philip Agop Philip.
JAMA Oncol, 2019 Jul 19; 5(10). PMID: 31318392    Free PMC article.
Highly Cited.
CD28 and CTLA-4 coreceptor expression and signal transduction.
Christopher E Rudd, Alison Taylor, Helga Schneider.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426212    Free PMC article.
Highly Cited. Review.
Neutralizing tumor-promoting chronic inflammation: a magic bullet?
Lisa M Coussens, Laurence Zitvogel, A Karolina Palucka.
Science, 2013 Jan 19; 339(6117). PMID: 23329041    Free PMC article.
Highly Cited. Review.
Emerging principles for the recognition of peptide antigens by MHC class I molecules.
M Matsumura, D H Fremont, P A Peterson, I A Wilson.
Science, 1992 Aug 14; 257(5072). PMID: 1323878
Highly Cited.
Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer.
Sandra Demaria, Noriko Kawashima, +4 authors, Silvia C Formenti.
Clin Cancer Res, 2005 Feb 11; 11(2 Pt 1). PMID: 15701862
Highly Cited.
A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing.
Patrick H Lizotte, Ruey-Long Hong, +16 authors, Pasi A Jänne.
Cancer Immunol Res, 2018 Sep 23; 6(12). PMID: 30242021    Free PMC article.
Immune monitoring of the circulation and the tumor microenvironment in patients with regionally advanced melanoma receiving neoadjuvant ipilimumab.
Ahmad A Tarhini, Howard Edington, +9 authors, John M Kirkwood.
PLoS One, 2014 Feb 06; 9(2). PMID: 24498358    Free PMC article.
Highly Cited.
Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression.
Robin Maximilian Awad, Yannick De Vlaeminck, +2 authors, Karine Breckpot.
Front Immunol, 2018 Sep 21; 9. PMID: 30233579    Free PMC article.
Highly Cited. Review.
Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment.
Jayme B Stokes, Sara J Adair, +10 authors, Todd W Bauer.
Mol Cancer Ther, 2011 Sep 10; 10(11). PMID: 21903606    Free PMC article.
Highly Cited.
Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR.
Noa Stanietsky, Tihana Lenac Rovis, +6 authors, Ofer Mandelboim.
Eur J Immunol, 2013 May 17; 43(8). PMID: 23677581    Free PMC article.
Identification of essential genes for cancer immunotherapy.
Shashank J Patel, Neville E Sanjana, +21 authors, Nicholas P Restifo.
Nature, 2017 Aug 08; 548(7669). PMID: 28783722    Free PMC article.
Highly Cited.
Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens.
Anik L Côté, Peisheng Zhang, +5 authors, Mary Jo Turk.
J Immunol, 2010 Nov 26; 186(1). PMID: 21106849    Free PMC article.
Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells.
Matthew A Lakins, Ehsan Ghorani, +2 authors, Jacqueline D Shields.
Nat Commun, 2018 Mar 07; 9(1). PMID: 29507342    Free PMC article.
Highly Cited.
Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death.
Encouse B Golden, Derek Frances, +3 authors, Silvia C Formenti.
Oncoimmunology, 2014 Jul 30; 3. PMID: 25071979    Free PMC article.
Highly Cited.
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Xin Yu, Kristin Harden, +9 authors, Jane L Grogan.
Nat Immunol, 2008 Nov 18; 10(1). PMID: 19011627
Highly Cited.
Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial.
Bradley C Carthon, Jedd D Wolchok, +8 authors, Padmanee Sharma.
Clin Cancer Res, 2010 May 13; 16(10). PMID: 20460488    Free PMC article.
Highly Cited.
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.
Hong Jiang, Samarth Hegde, +10 authors, David G DeNardo.
Nat Med, 2016 Jul 05; 22(8). PMID: 27376576    Free PMC article.
Highly Cited.
Melanoma brain metastases treated with stereotactic radiosurgery and concurrent pembrolizumab display marked regression; efficacy and safety of combined treatment.
Erik S Anderson, Michael A Postow, +5 authors, Kathryn Beal.
J Immunother Cancer, 2017 Oct 19; 5(1). PMID: 29037215    Free PMC article.
Highly Cited.
CheckMate-032 Study: Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Patients With Metastatic Esophagogastric Cancer.
Yelena Y Janjigian, Johanna Bendell, +13 authors, Dung T Le.
J Clin Oncol, 2018 Aug 16; 36(28). PMID: 30110194    Free PMC article.
Highly Cited.
CAR T cells for solid tumors: armed and ready to go?
Sunitha Kakarla, Stephen Gottschalk.
Cancer J, 2014 Mar 29; 20(2). PMID: 24667962    Free PMC article.
Highly Cited. Review.
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy.
Spencer C Wei, Colm R Duffy, James P Allison.
Cancer Discov, 2018 Aug 18; 8(9). PMID: 30115704
Highly Cited. Review.
Treatment with anti-programmed cell death 1 (PD-1) antibody restored postoperative CD8+ T cell dysfunction by surgical stress.
Zhirong Sun, Anrong Mao, +4 authors, Changhong Miao.
Biomed Pharmacother, 2017 Mar 23; 89. PMID: 28320090
Pembrolizumab monotherapy for previously treated metastatic triple-negative breast cancer: cohort A of the phase II KEYNOTE-086 study.
S Adams, P Schmid, +18 authors, J Cortés.
Ann Oncol, 2018 Nov 27; 30(3). PMID: 30475950
Highly Cited.
A Prospective Clinical Trial Combining Radiation Therapy With Systemic Immunotherapy in Metastatic Melanoma.
Susan M Hiniker, Sunil A Reddy, +6 authors, Susan J Knox.
Int J Radiat Oncol Biol Phys, 2016 Sep 30; 96(3). PMID: 27681753    Free PMC article.
Highly Cited.
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.
Enfu Hui, Jeanne Cheung, +8 authors, Ronald D Vale.
Science, 2017 Mar 11; 355(6332). PMID: 28280247    Free PMC article.
Highly Cited.
Incorporation of Immune Checkpoint Blockade into Chimeric Antigen Receptor T Cells (CAR-Ts): Combination or Built-In CAR-T.
Dok Hyun Yoon, Mark J Osborn, Jakub Tolar, Chong Jai Kim.
Int J Mol Sci, 2018 Jan 25; 19(2). PMID: 29364163    Free PMC article.
Highly Cited. Review.
CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy.
Hong Chen, Tihui Fu, +7 authors, Padmanee Sharma.
Cancer Immunol Res, 2014 Apr 30; 2(2). PMID: 24778280    Free PMC article.
Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma.
Robert J Motzer, Nizar M Tannir, +30 authors, CheckMate 214 Investigators.
N Engl J Med, 2018 Mar 22; 378(14). PMID: 29562145    Free PMC article.
Highly Cited.
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.
Roy S Herbst, Jean-Charles Soria, +19 authors, F Stephen Hodi.
Nature, 2014 Nov 28; 515(7528). PMID: 25428504    Free PMC article.
Highly Cited.
Immunogenic death of colon cancer cells treated with oxaliplatin.
A Tesniere, F Schlemmer, +15 authors, G Kroemer.
Oncogene, 2009 Nov 03; 29(4). PMID: 19881547
Highly Cited.
Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer.
Satoshi Wada, Christopher M Jackson, +10 authors, Charles G Drake.
J Transl Med, 2013 Apr 06; 11. PMID: 23557194    Free PMC article.
Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice.
Liufu Deng, Hua Liang, +4 authors, Yang-Xin Fu.
J Clin Invest, 2014 Jan 03; 124(2). PMID: 24382348    Free PMC article.
Highly Cited.
Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors.
Hélène Salmon, Katarzyna Franciszkiewicz, +5 authors, Emmanuel Donnadieu.
J Clin Invest, 2012 Feb 02; 122(3). PMID: 22293174    Free PMC article.
Highly Cited.
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.
Chen Zhu, Ana C Anderson, +6 authors, Vijay K Kuchroo.
Nat Immunol, 2005 Nov 16; 6(12). PMID: 16286920
Highly Cited.
Anti-CD19 Chimeric Antigen Receptor T Cells in Combination With Nivolumab Are Safe and Effective Against Relapsed/Refractory B-Cell Non-hodgkin Lymphoma.
Yaqing Cao, Wenyi Lu, +7 authors, Mingfeng Zhao.
Front Oncol, 2019 Sep 05; 9. PMID: 31482064    Free PMC article.
Highly Cited.
Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer.
Michael J Overman, Sara Lonardi, +17 authors, Thierry André.
J Clin Oncol, 2018 Jan 23; 36(8). PMID: 29355075
Highly Cited.
Overcoming T cell exhaustion in infection and cancer.
Kristen E Pauken, E John Wherry.
Trends Immunol, 2015 Mar 24; 36(4). PMID: 25797516    Free PMC article.
Highly Cited. Review.
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Daniel Sanghoon Shin, Jesse M Zaretsky, +24 authors, Antoni Ribas.
Cancer Discov, 2016 Dec 03; 7(2). PMID: 27903500    Free PMC article.
Highly Cited.
Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study.
Scott Antonia, Sarah B Goldberg, +8 authors, Naiyer A Rizvi.
Lancet Oncol, 2016 Feb 10; 17(3). PMID: 26858122    Free PMC article.
Highly Cited.
Transforming growth factor-beta activation in irradiated murine mammary gland.
M H Barcellos-Hoff, R Derynck, M L Tsang, J A Weatherbee.
J Clin Invest, 1994 Feb 01; 93(2). PMID: 8113421    Free PMC article.
Highly Cited.
Ipilimumab and nivolumab in the treatment of recurrent malignant pleural mesothelioma (INITIATE): results of a prospective, single-arm, phase 2 trial.
Maria J Disselhorst, Josine Quispel-Janssen, +6 authors, Paul Baas.
Lancet Respir Med, 2019 Jan 21; 7(3). PMID: 30660511
Highly Cited.
Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer.
Valsamo Anagnostou, Kellie N Smith, +26 authors, Victor E Velculescu.
Cancer Discov, 2016 Dec 30; 7(3). PMID: 28031159    Free PMC article.
Highly Cited.
Prostaglandin e(2) suppresses NK activity in vivo and promotes postoperative tumor metastasis in rats.
Ilan Yakar, Rivka Melamed, +5 authors, Shamgar Ben-Eliyahu.
Ann Surg Oncol, 2003 May 08; 10(4). PMID: 12734098
Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition.
Leonid Cherkassky, Aurore Morello, +5 authors, Prasad S Adusumilli.
J Clin Invest, 2016 Jul 28; 126(8). PMID: 27454297    Free PMC article.
Highly Cited.
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.
Eiichi Sato, Sara H Olson, +15 authors, Kunle Odunsi.
Proc Natl Acad Sci U S A, 2005 Dec 14; 102(51). PMID: 16344461    Free PMC article.
Highly Cited.
Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function.
Jessica Ann Hernandez-Chacon, Yufeng Li, +5 authors, Laszlo G Radvanyi.
J Immunother, 2011 Mar 11; 34(3). PMID: 21389874    Free PMC article.
Immunological correlates of treatment and response in stage IV malignant melanoma patients treated with Ipilimumab.
Jon Bjoern, Nikolaj Juul Nitschke, +3 authors, Inge Marie Svane.
Oncoimmunology, 2016 May 04; 5(4). PMID: 27141381    Free PMC article.
Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody.
M Zahidunnabi Dewan, Ashley E Galloway, +4 authors, Sandra Demaria.
Clin Cancer Res, 2009 Aug 27; 15(17). PMID: 19706802    Free PMC article.
Highly Cited.
MHC class I antigens and immune surveillance in transformed cells.
Natalia Aptsiauri, Teresa Cabrera, +3 authors, Federico Garrido.
Int Rev Cytol, 2007 Jan 24; 256. PMID: 17241907
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.
Nicholas McGranahan, Andrew J S Furness, +33 authors, Charles Swanton.
Science, 2016 Mar 05; 351(6280). PMID: 26940869    Free PMC article.
Highly Cited.
Prospect of targeting the CD40 pathway for cancer therapy.
Robert H Vonderheide.
Clin Cancer Res, 2007 Feb 24; 13(4). PMID: 17317815
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.
A Hutloff, A M Dittrich, +4 authors, R A Kroczek.
Nature, 1999 Feb 04; 397(6716). PMID: 9930702
Highly Cited.
CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool.
Jenny Hendriks, Yanling Xiao, Jannie Borst.
J Exp Med, 2003 Oct 29; 198(9). PMID: 14581610    Free PMC article.
Highly Cited.
Major abdominal surgery increases plasma levels of vascular endothelial growth factor: open more so than minimally invasive methods.
Avraham Belizon, Emre Balik, +8 authors, Richard L Whelan.
Ann Surg, 2006 Oct 25; 244(5). PMID: 17060773    Free PMC article.
Effector memory T cells, early metastasis, and survival in colorectal cancer.
Franck Pagès, Anne Berger, +13 authors, Jérôme Galon.
N Engl J Med, 2005 Dec 24; 353(25). PMID: 16371631
Highly Cited.
Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells.
Liza B John, Christel Devaud, +7 authors, Phillip K Darcy.
Clin Cancer Res, 2013 Jul 23; 19(20). PMID: 23873688
Highly Cited.
Helper T Cells and Cancer-Associated Inflammation: A New Direction for Immunotherapy?
Chen Dong.
J Interferon Cytokine Res, 2017 Jul 21; 37(9). PMID: 28727936
Combining Immune Checkpoint Blockade and Tumor-Specific Vaccine for Patients With Incurable Human Papillomavirus 16-Related Cancer: A Phase 2 Clinical Trial.
Erminia Massarelli, William William, +18 authors, Bonnie Glisson.
JAMA Oncol, 2018 Sep 30; 5(1). PMID: 30267032    Free PMC article.
Highly Cited.
A basal membrane-like structure surrounding tumour nodules may prevent intraepithelial leucocyte infiltration in colorectal cancer.
Anand G Menon, Gert Jan Fleuren, +7 authors, Peter J K Kuppen.
Cancer Immunol Immunother, 2003 Feb 21; 52(2). PMID: 12594576
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients.
V Gopalakrishnan, C N Spencer, +67 authors, J A Wargo.
Science, 2017 Nov 04; 359(6371). PMID: 29097493    Free PMC article.
Highly Cited.
Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated.
Sandra Demaria, Bruce Ng, +4 authors, Silvia C Formenti.
Int J Radiat Oncol Biol Phys, 2004 Feb 18; 58(3). PMID: 14967443
Highly Cited.
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Ayelet Sivan, Leticia Corrales, +9 authors, Thomas F Gajewski.
Science, 2015 Nov 07; 350(6264). PMID: 26541606    Free PMC article.
Highly Cited.
Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivo.
Rituparna Das, Rakesh Verma, +8 authors, Kavita M Dhodapkar.
J Immunol, 2014 Dec 30; 194(3). PMID: 25539810    Free PMC article.
Highly Cited.
Immunologic correlates of the abscopal effect in a patient with melanoma.
Michael A Postow, Margaret K Callahan, +18 authors, Jedd D Wolchok.
N Engl J Med, 2012 Mar 09; 366(10). PMID: 22397654    Free PMC article.
Highly Cited.
Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial.
M Reck, I Bondarenko, +7 authors, T J Lynch.
Ann Oncol, 2012 Aug 04; 24(1). PMID: 22858559
Highly Cited.
Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.
Udupi A Ramagopal, Weifeng Liu, +10 authors, Steven C Almo.
Proc Natl Acad Sci U S A, 2017 May 10; 114(21). PMID: 28484017    Free PMC article.
Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer.
Matthew D Hellmann, Tavi Nathanson, +29 authors, Jedd D Wolchok.
Cancer Cell, 2018 Apr 17; 33(5). PMID: 29657128    Free PMC article.
Highly Cited.
Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma.
Jedd D Wolchok, Vanna Chiarion-Sileni, +30 authors, James Larkin.
N Engl J Med, 2017 Sep 12; 377(14). PMID: 28889792    Free PMC article.
Highly Cited.
Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy.
Christina Pfirschke, Camilla Engblom, +18 authors, Mikael J Pittet.
Immunity, 2016 Feb 14; 44(2). PMID: 26872698    Free PMC article.
Highly Cited.
Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions.
Antje Sucker, Fang Zhao, +20 authors, Annette Paschen.
Nat Commun, 2017 Jun 01; 8. PMID: 28561041    Free PMC article.
Highly Cited.
A biological role for the major histocompatibility antigens.
P C Doherty, R M Zinkernagel.
Lancet, 1975 Jun 28; 1(7922). PMID: 49564
Highly Cited.
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses.
W W Shuford, K Klussman, +11 authors, R S Mittler.
J Exp Med, 1997 Jul 07; 186(1). PMID: 9206996    Free PMC article.
Highly Cited.
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance.
Jun Shimizu, Sayuri Yamazaki, +2 authors, Shimon Sakaguchi.
Nat Immunol, 2002 Jan 29; 3(2). PMID: 11812990
Highly Cited.
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy.
Steven A Rosenberg, James C Yang, +12 authors, Mark E Dudley.
Clin Cancer Res, 2011 Apr 19; 17(13). PMID: 21498393    Free PMC article.
Highly Cited.
Immune Priming of the Tumor Microenvironment by Radiation.
Wen Jiang, Charles K Chan, +2 authors, Stephen M Hahn.
Trends Cancer, 2017 Jul 26; 2(11). PMID: 28741502
Mechanisms regulating T-cell infiltration and activity in solid tumors.
E Lanitis, D Dangaj, M Irving, G Coukos.
Ann Oncol, 2017 Oct 19; 28(suppl_12). PMID: 29045511
Highly Cited.
Genetic evolution of T-cell resistance in the course of melanoma progression.
Antje Sucker, Fang Zhao, +16 authors, Annette Paschen.
Clin Cancer Res, 2014 Oct 09; 20(24). PMID: 25294904    Free PMC article.
Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade.
Janis M Taube, Geoffrey D Young, +10 authors, Suzanne L Topalian.
Clin Cancer Res, 2015 May 07; 21(17). PMID: 25944800    Free PMC article.
Highly Cited.
Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance.
F M Marincola, E M Jaffee, D J Hicklin, S Ferrone.
Adv Immunol, 1999 Dec 22; 74. PMID: 10605607
Highly Cited. Review.
Molecular mechanism and function of CD40/CD40L engagement in the immune system.
Raul Elgueta, Micah J Benson, +3 authors, Randolph J Noelle.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426221    Free PMC article.
Highly Cited. Review.
Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial.
Narek Shaverdian, Aaron E Lisberg, +5 authors, Percy Lee.
Lancet Oncol, 2017 May 30; 18(7). PMID: 28551359    Free PMC article.
Highly Cited.
In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy.
Sean P Arlauckas, Christopher S Garris, +9 authors, Mikael J Pittet.
Sci Transl Med, 2017 May 12; 9(389). PMID: 28490665    Free PMC article.
Highly Cited.
Synergistic effect of CTLA-4 blockade and cancer chemotherapy in the induction of anti-tumor immunity.
W Joost Lesterhuis, Joanne Salmons, +6 authors, Richard A Lake.
PLoS One, 2013 Apr 30; 8(4). PMID: 23626745    Free PMC article.
Radiation improves antitumor effect of immune checkpoint inhibitor in murine hepatocellular carcinoma model.
Kyoung-Jin Kim, Ji-Hye Kim, +3 authors, Jinsil Seong.
Oncotarget, 2017 May 04; 8(25). PMID: 28465485    Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Impact of oncogenic pathways on evasion of antitumour immune responses.
Stefani Spranger, Thomas F Gajewski.
Nat Rev Cancer, 2018 Jan 13; 18(3). PMID: 29326431    Free PMC article.
Highly Cited. Review.
Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo.
Creg J Workman, Linda S Cauley, +3 authors, Dario A A Vignali.
J Immunol, 2004 Apr 22; 172(9). PMID: 15100286
Chimeric antigen receptor T-cell therapy for ALL.
Shannon L Maude, Elizabeth J Shpall, Stephan A Grupp.
Hematology Am Soc Hematol Educ Program, 2015 Feb 20; 2014(1). PMID: 25696911
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
Bertrand Routy, Emmanuelle Le Chatelier, +45 authors, Laurence Zitvogel.
Science, 2017 Nov 04; 359(6371). PMID: 29097494
Highly Cited.
Significant detection of circulating cancer cells in the blood by reverse transcriptase-polymerase chain reaction during colorectal cancer resection.
K Yamaguchi, Y Takagi, +2 authors, S Saji.
Ann Surg, 2000 Jun 22; 232(1). PMID: 10862196    Free PMC article.
The dual-function CD150 receptor subfamily: the viral attraction.
Svetlana P Sidorenko, Edward A Clark.
Nat Immunol, 2002 Dec 24; 4(1). PMID: 12496974
New Hope for Therapeutic Cancer Vaccines in the Era of Immune Checkpoint Modulation.
Michael A Curran, Bonnie S Glisson.
Annu Rev Med, 2018 Nov 01; 70. PMID: 30379596
Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.
Weiyi Peng, Jie Qing Chen, +41 authors, Patrick Hwu.
Cancer Discov, 2015 Dec 10; 6(2). PMID: 26645196    Free PMC article.
Highly Cited.
Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade.
Simon J Dovedi, Amy L Adlard, +11 authors, Tim M Illidge.
Cancer Res, 2014 Oct 03; 74(19). PMID: 25274032
Highly Cited.
Elements of cancer immunity and the cancer-immune set point.
Daniel S Chen, Ira Mellman.
Nature, 2017 Jan 20; 541(7637). PMID: 28102259
Highly Cited. Review.
Prospects for gene-engineered T cell immunotherapy for solid cancers.
Christopher A Klebanoff, Steven A Rosenberg, Nicholas P Restifo.
Nat Med, 2016 Jan 07; 22(1). PMID: 26735408    Free PMC article.
Highly Cited.
Sipuleucel-T (provenge) injection: the first immunotherapy agent (vaccine) for hormone-refractory prostate cancer.
Enock Anassi, Uche Anadu Ndefo.
P T, 2011 May 17; 36(4). PMID: 21572775    Free PMC article.
Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing.
Hira Rizvi, Francisco Sanchez-Vega, +29 authors, Matthew D Hellmann.
J Clin Oncol, 2018 Jan 18; 36(7). PMID: 29337640    Free PMC article.
Highly Cited.
PD-1 blockade enhances the vaccination-induced immune response in glioma.
Joseph P Antonios, Horacio Soto, +9 authors, Robert M Prins.
JCI Insight, 2016 Jul 28; 1(10). PMID: 27453950    Free PMC article.
Highly Cited.
PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T-cell infiltration into pancreatic tumors.
Kevin C Soares, Agnieszka A Rucki, +15 authors, Lei Zheng.
J Immunother, 2014 Nov 22; 38(1). PMID: 25415283    Free PMC article.
Highly Cited.
A novel transcription factor, T-bet, directs Th1 lineage commitment.
S J Szabo, S T Kim, +3 authors, L H Glimcher.
Cell, 2000 Apr 13; 100(6). PMID: 10761931
Highly Cited.
Cancer immune contexture and immunotherapy.
Etienne Becht, Nicolas A Giraldo, +2 authors, Wolf Herman Fridman.
Curr Opin Immunol, 2015 Dec 29; 39. PMID: 26708937
Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen.
Andrew B Sharabi, Christopher J Nirschl, +5 authors, Charles G Drake.
Cancer Immunol Res, 2014 Dec 21; 3(4). PMID: 25527358    Free PMC article.
Highly Cited.
Systematic review of case reports on the abscopal effect.
Yazan Abuodeh, Puja Venkat, Sungjune Kim.
Curr Probl Cancer, 2015 Nov 20; 40(1). PMID: 26582738
Highly Cited. Systematic Review.
PD-L2 is a second ligand for PD-1 and inhibits T cell activation.
Y Latchman, C R Wood, +18 authors, G J Freeman.
Nat Immunol, 2001 Feb 27; 2(3). PMID: 11224527
Highly Cited.
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.
Susanne J Szabo, Brandon M Sullivan, +3 authors, Laurie H Glimcher.
Science, 2002 Jan 12; 295(5553). PMID: 11786644
Highly Cited.
Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.
Alan Serrels, Tom Lund, +15 authors, Margaret C Frame.
Cell, 2015 Sep 26; 163(1). PMID: 26406376    Free PMC article.
Highly Cited.
Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer.
Matthew D Hellmann, Margaret K Callahan, +13 authors, Scott J Antonia.
Cancer Cell, 2018 May 08; 33(5). PMID: 29731394    Free PMC article.
Highly Cited.
Control of lymphocyte function through CD27-CD70 interactions.
S M Lens, K Tesselaar, M H van Oers, R A van Lier.
Semin Immunol, 1998 Nov 25; 10(6). PMID: 9826582
Zooming into the binding groove of HLA molecules: which positions and which substitutions change peptide binding most?
Hanneke W M van Deutekom, Can Keşmir.
Immunogenetics, 2015 Jun 05; 67(8). PMID: 26040913    Free PMC article.
PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity.
Martin W LaFleur, Thao H Nguyen, +9 authors, Arlene H Sharpe.
Nat Immunol, 2019 Sep 19; 20(10). PMID: 31527834    Free PMC article.
Combination anti-CTLA-4 plus anti-PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies.
Spencer C Wei, Nana-Ama A S Anang, +8 authors, James P Allison.
Proc Natl Acad Sci U S A, 2019 Oct 23; 116(45). PMID: 31636208    Free PMC article.
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.
Gordon W McLean, Neil O Carragher, +3 authors, Margaret C Frame.
Nat Rev Cancer, 2005 Aug 03; 5(7). PMID: 16069815
Highly Cited. Review.
Radiation enhances regulatory T cell representation.
Evelyn L Kachikwu, Keisuke S Iwamoto, +5 authors, Dörthe Schaue.
Int J Radiat Oncol Biol Phys, 2010 Nov 26; 81(4). PMID: 21093169    Free PMC article.
Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?
Giuseppe Badalamenti, Daniele Fanale, +8 authors, Antonio Russo.
Cell Immunol, 2018 Feb 06; 343. PMID: 29395859
Highly Cited. Review.
Clinical and Molecular Characteristics Associated With Survival Among Patients Treated With Checkpoint Inhibitors for Advanced Non-Small Cell Lung Carcinoma: A Systematic Review and Meta-analysis.
Chee Khoon Lee, Johnathan Man, +7 authors, James Chih-Hsin Yang.
JAMA Oncol, 2017 Dec 23; 4(2). PMID: 29270615    Free PMC article.
Highly Cited. Systematic Review.
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Omar S Qureshi, Yong Zheng, +12 authors, David M Sansom.
Science, 2011 Apr 09; 332(6029). PMID: 21474713    Free PMC article.
Highly Cited.
Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial.
Kohei Shitara, Mustafa Özgüroğlu, +18 authors, KEYNOTE-061 investigators.
Lancet, 2018 Jun 09; 392(10142). PMID: 29880231
Highly Cited.
Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors.
Esra A Akbay, Shohei Koyama, +24 authors, Kwok-Kin Wong.
Cancer Discov, 2013 Oct 01; 3(12). PMID: 24078774    Free PMC article.
Highly Cited.
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity.
Stefani Spranger, Riyue Bao, Thomas F Gajewski.
Nature, 2015 May 15; 523(7559). PMID: 25970248
Highly Cited.
OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells.
P R Rogers, J Song, +2 authors, M Croft.
Immunity, 2001 Sep 25; 15(3). PMID: 11567634
Highly Cited.
Human Th1 dichotomy: origin, phenotype and biologic activities.
Francesco Annunziato, Lorenzo Cosmi, +2 authors, Sergio Romagnani.
Immunology, 2014 Oct 07;. PMID: 25284714    Free PMC article.
Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab.
Christiane Meyer, Laurène Cagnon, +6 authors, Daniel E Speiser.
Cancer Immunol Immunother, 2013 Dec 21; 63(3). PMID: 24357148
Highly Cited.
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy.
Jianjun Gao, Lewis Zhichang Shi, +13 authors, Padmanee Sharma.
Cell, 2016 Sep 27; 167(2). PMID: 27667683    Free PMC article.
Highly Cited.
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy.
Diego Chowell, Luc G T Morris, +17 authors, Timothy A Chan.
Science, 2017 Dec 09; 359(6375). PMID: 29217585    Free PMC article.
Highly Cited.
Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR.
A L Gurney, S A Marsters, +13 authors, A Ashkenazi.
Curr Biol, 1999 Mar 13; 9(4). PMID: 10074428
GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations.
Simona Ronchetti, Ornella Zollo, +5 authors, Carlo Riccardi.
Eur J Immunol, 2004 Mar 03; 34(3). PMID: 14991590
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.
Jesse M Zaretsky, Angel Garcia-Diaz, +26 authors, Antoni Ribas.
N Engl J Med, 2016 Jul 20; 375(9). PMID: 27433843    Free PMC article.
Highly Cited.
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.
Dung T Le, Jennifer N Durham, +43 authors, Luis A Diaz.
Science, 2017 Jun 10; 357(6349). PMID: 28596308    Free PMC article.
Highly Cited.
Ipilimumab plus nivolumab and DNA-repair defects in AR-V7-expressing metastatic prostate cancer.
Karim Boudadi, Daniel L Suzman, +25 authors, Emmanuel S Antonarakis.
Oncotarget, 2018 Jul 10; 9(47). PMID: 29983880    Free PMC article.
Highly Cited.
PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity.
Maria Gato-Cañas, Miren Zuazo, +14 authors, David Escors.
Cell Rep, 2017 Aug 24; 20(8). PMID: 28834746
Highly Cited.
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.
Noriho Iida, Amiran Dzutsev, +18 authors, Romina S Goldszmid.
Science, 2013 Nov 23; 342(6161). PMID: 24264989    Free PMC article.
Highly Cited.
PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta.
Kelly-Ann Sheppard, Lori J Fitz, +8 authors, Divya Chaudhary.
FEBS Lett, 2004 Sep 11; 574(1-3). PMID: 15358536
Highly Cited.
PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity.
Vikram R Juneja, Kathleen A McGuire, +5 authors, Arlene H Sharpe.
J Exp Med, 2017 Mar 18; 214(4). PMID: 28302645    Free PMC article.
Highly Cited.
PD-1 Restrains Radiotherapy-Induced Abscopal Effect.
Sean S Park, Haidong Dong, +7 authors, Eugene D Kwon.
Cancer Immunol Res, 2015 Feb 24; 3(6). PMID: 25701325    Free PMC article.
Highly Cited.
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.
Rebecca S McHugh, Matthew J Whitters, +4 authors, Michael C Byrne.
Immunity, 2002 Mar 01; 16(2). PMID: 11869690
Highly Cited.
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.
Santiago Zelenay, Annemarthe G van der Veen, +9 authors, Caetano Reis e Sousa.
Cell, 2015 Sep 08; 162(6). PMID: 26343581    Free PMC article.
Highly Cited.
Serum and Glucocorticoid-Inducible Kinase 1 (SGK1) in NSCLC Therapy.
Ilaria Guerriero, Gianni Monaco, Vincenzo Coppola, Arturo Orlacchio.
Pharmaceuticals (Basel), 2020 Dec 04; 13(11). PMID: 33266470    Free PMC article.
Primary and Acquired Resistance to Immunotherapy in Lung Cancer: Unveiling the Mechanisms Underlying of Immune Checkpoint Blockade Therapy.
Laura Boyero, Amparo Sánchez-Gastaldo, +3 authors, Reyes Bernabé-Caro.
Cancers (Basel), 2020 Dec 17; 12(12). PMID: 33322522    Free PMC article.
The Sarcoma Immune Landscape: Emerging Challenges, Prognostic Significance and Prospective Impact for Immunotherapy Approaches.
Anna Koumarianou, Jose Duran-Moreno.
Cancers (Basel), 2021 Jan 28; 13(3). PMID: 33498238    Free PMC article.
Biomarkers for precision immunotherapy in the metastatic setting: hope or reality?
Elham Sajjadi, Konstantinos Venetis, Cristian Scatena, Nicola Fusco.
Ecancermedicalscience, 2021 Feb 13; 14. PMID: 33574895    Free PMC article.
Thinking Small: Small Molecules as Potential Synergistic Adjuncts to Checkpoint Inhibition in Melanoma.
Alexander C Chacon, Alexa D Melucci, Shuyang S Qin, Peter A Prieto.
Int J Mol Sci, 2021 Apr 04; 22(6). PMID: 33810078    Free PMC article.
Immunotherapy for Hepatocellular Carcinoma: Current Limits and Prospects.
Cheng Zhong, Yirun Li, +5 authors, Hui Lin.
Front Oncol, 2021 Apr 16; 11. PMID: 33854960    Free PMC article.
Baseline Modified Glasgow Prognostic Score Associated with Survival in Metastatic Urothelial Carcinoma Treated with Immune Checkpoint Inhibitors.
Jacqueline T Brown, Yuan Liu, +14 authors, Mehmet Asim Bilen.
Oncologist, 2021 Feb 27; 26(5). PMID: 33634507    Free PMC article.
Cancer-Associated Fibroblasts and Tumor-Associated Macrophages in Cancer and Cancer Immunotherapy.
Hans Raskov, Adile Orhan, Shruti Gaggar, Ismail Gögenur.
Front Oncol, 2021 Jun 08; 11. PMID: 34094963    Free PMC article.
The Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy.
Bonnie L Russell, Selisha A Sooklal, +2 authors, Monde Ntwasa.
Front Oncol, 2021 Jul 17; 11. PMID: 34268109    Free PMC article.
Failure of Immunotherapy-The Molecular and Immunological Origin of Immunotherapy Resistance in Lung Cancer.
Justyna Błach, Kamila Wojas-Krawczyk, Marcin Nicoś, Paweł Krawczyk.
Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445735    Free PMC article.
Mining the Gut Microbiota for Microbial-Based Therapeutic Strategies in Cancer Immunotherapy.
Bolei Li, Tao Gong, +2 authors, Lei Cheng.
Front Oncol, 2021 Oct 01; 11. PMID: 34589427    Free PMC article.
Acquired resistance for immune checkpoint inhibitors in cancer immunotherapy: challenges and prospects.
Xunrui Chen, Wenhui Zhang, +2 authors, Feng Liu.
Aging (Albany NY), 2022 Jan 18; 14(2). PMID: 35037899    Free PMC article.
TNF Family-Based Signature Predicts Prognosis, Tumor Microenvironment, and Molecular Subtypes in Bladder Carcinoma.
Huihuang Li, Siyuan Liu, +3 authors, Cheng Zhao.
Front Cell Dev Biol, 2022 Feb 18; 9. PMID: 35174161    Free PMC article.