Review
. 2020 Mar; 96(3):550-559.
doi: 10.1111/php.13253.

Photodynamic Therapy and Immunity: An Update

Riddhi Falk-Mahapatra 1 Sandra O Gollnick 1 
Affiliations
  • PMID: 32128821
  •     121 References
  •     22 citations

Abstract

Dr. Thomas Dougherty and his Oncology Foundation of Buffalo were the first to support my (S.O.G.) research into the effects of photodynamic therapy (PDT) on the host immune system. The small grant I was awarded in 2002 launched my career as an independent researcher; at the time, there were few studies on the importance of the immune response on the efficacy of PDT and no studies demonstrating the ability of PDT to enhance antitumor immunity. Over the last decades, the interest in PDT as an enhancer of antitumor immunity and our understanding of the mechanisms by which PDT enhances antitumor immunity have dramatically increased. In this review article, we look back on the studies that laid the foundation for our understanding and provide an update on current advances and therapies that take advantage of PDT enhancement of immunity.

Neutrophils as inflammatory and immune effectors in photodynamic therapy-treated mouse SCCVII tumours.
Jinghai Sun, Ivana Cecic, Charles S Parkins, Mladen Korbelik.
Photochem Photobiol Sci, 2003 Apr 01; 1(9). PMID: 12665307
Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses.
Dong Sun Oh, Heegon Kim, +4 authors, Heung Kyu Lee.
Oncotarget, 2017 May 26; 8(29). PMID: 28537894    Free PMC article.
Inhibition of lymphangiogenesis impairs antitumour effects of photodynamic therapy and checkpoint inhibitors in mice.
Angelika Muchowicz, Malgorzata Wachowska, +8 authors, Jakub Golab.
Eur J Cancer, 2017 Jul 15; 83. PMID: 28709135
Prostaglandin E2 regulates tumor angiogenesis in prostate cancer.
Shalini Jain, Goutam Chakraborty, +2 authors, Gopal C Kundu.
Cancer Res, 2008 Oct 03; 68(19). PMID: 18829529
Enhanced Immunotherapy Based on Photodynamic Therapy for Both Primary and Lung Metastasis Tumor Eradication.
Wen Song, Jing Kuang, +5 authors, Xian-Zheng Zhang.
ACS Nano, 2018 Feb 09; 12(2). PMID: 29420012
Initiation of autophagy by photodynamic therapy.
David Kessel, Nancy L Oleinick.
Methods Enzymol, 2009 Feb 17; 453. PMID: 19216899    Free PMC article.
Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment.
Meghan B Azad, Yongqiang Chen, Spencer B Gibson.
Antioxid Redox Signal, 2008 Oct 03; 11(4). PMID: 18828708
Highly Cited. Review.
Role of complement anaphylatoxin C3a in photodynamic therapy-elicited engagement of host neutrophils and other immune cells.
Ivana Cecic, Jinghai Sun, Mladen Korbelik.
Photochem Photobiol, 2006 Apr 15; 82(2). PMID: 16613513
Enhancement of anti-tumor immunity by photodynamic therapy.
Sandra O Gollnick, Craig M Brackett.
Immunol Res, 2009 Sep 19; 46(1-3). PMID: 19763892    Free PMC article.
Review.
Role of cytokines in photodynamic therapy-induced local and systemic inflammation.
S O Gollnick, S S Evans, +6 authors, B W Henderson.
Br J Cancer, 2003 May 29; 88(11). PMID: 12771994    Free PMC article.
Along the Axis between Type 1 and Type 2 Immunity; Principles Conserved in Evolution from Fish to Mammals.
Takuya Yamaguchi, Fumio Takizawa, Uwe Fischer, Johannes M Dijkstra.
Biology (Basel), 2015 Nov 26; 4(4). PMID: 26593954    Free PMC article.
Review.
Openings between defective endothelial cells explain tumor vessel leakiness.
H Hashizume, P Baluk, +5 authors, D M McDonald.
Am J Pathol, 2000 Apr 07; 156(4). PMID: 10751361    Free PMC article.
Highly Cited.
Photodynamic therapy.
T J Dougherty, C J Gomer, +5 authors, Q Peng.
J Natl Cancer Inst, 1998 Jun 24; 90(12). PMID: 9637138    Free PMC article.
Highly Cited. Review.
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice.
Mickaël Michaud, Isabelle Martins, +16 authors, Guido Kroemer.
Science, 2011 Dec 17; 334(6062). PMID: 22174255
Highly Cited.
Biological and clinical significance of T helper 17 cell plasticity.
Alessio Mazzoni, Laura Maggi, +2 authors, Francesco Annunziato.
Immunology, 2019 Oct 01; 158(4). PMID: 31566706    Free PMC article.
Review.
Effect of photodynamic therapy on tumor necrosis factor production by murine macrophages.
S Evans, W Matthews, +3 authors, H I Pass.
J Natl Cancer Inst, 1990 Jan 03; 82(1). PMID: 2293654
Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors.
Barbara W Henderson, Sandra O Gollnick, +4 authors, Janet Morgan.
Cancer Res, 2004 Mar 18; 64(6). PMID: 15026352
Cyclooxygenase-2 inhibitor treatment enhances photodynamic therapy-mediated tumor response.
Angela Ferrario, Karl Von Tiehl, +2 authors, Charles J Gomer.
Cancer Res, 2002 Jul 19; 62(14). PMID: 12124326
Phthalocyanine 4 photodynamic therapy-induced apoptosis of mouse L5178Y-R cells results from a delayed but extensive release of cytochrome c from mitochondria.
S Chiu, H H Evans, +2 authors, N L Oleinick.
Cancer Lett, 2001 Mar 15; 165(1). PMID: 11248418
Photophysical and photobiological processes in the photodynamic therapy of tumours.
M Ochsner.
J Photochem Photobiol B, 1997 May 01; 39(1). PMID: 9210318
Highly Cited. Review.
Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy.
Yuanhong Zheng, Guifang Yin, +4 authors, Jianwen Liu.
Int J Biol Sci, 2016 Jan 02; 12(1). PMID: 26722223    Free PMC article.
Photosensitizer-conjugated polymeric nanoparticles for redox-responsive fluorescence imaging and photodynamic therapy.
Hyunjin Kim, Saehun Mun, Yongdoo Choi.
J Mater Chem B, 2013 Jan 28; 1(4). PMID: 32260811
Altered expression of interleukin 6 and interleukin 10 as a result of photodynamic therapy in vivo.
S O Gollnick, X Liu, +2 authors, B W Henderson.
Cancer Res, 1997 Oct 27; 57(18). PMID: 9307269
Photodynamic therapy-mediated immune response against subcutaneous mouse tumors.
M Korbelik, G J Dougherty.
Cancer Res, 1999 Apr 23; 59(8). PMID: 10213504
Efficacy and safety of continuous low-irradiance photodynamic therapy in the treatment of chest wall progression of breast cancer.
Sara A Morrison, Sam L Hill, Gary S Rogers, Roger A Graham.
J Surg Res, 2014 Jul 22; 192(2). PMID: 25043529
Bid is required in NPe6-PDT-induced apoptosis.
Qingling Wan, Lei Liu, Da Xing, Qun Chen.
Photochem Photobiol, 2008 Jan 05; 84(1). PMID: 18173728
Enhanced apoptotic response to photodynamic therapy after bcl-2 transfection.
H R Kim, Y Luo, G Li, D Kessel.
Cancer Res, 1999 Jul 23; 59(14). PMID: 10416606    Free PMC article.
Upregulation of genes for C-reactive protein and related pentraxin/complement proteins in photodynamic therapy-treated human tumor cells: enrolment of PI3K/Akt and AP-1.
Soroush Merchant, Mladen Korbelik.
Immunobiology, 2012 Nov 28; 218(6). PMID: 23182717
Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives.
Yamin Yang, Yue Hu, Hongjun Wang.
Oxid Med Cell Longev, 2016 Sep 28; 2016. PMID: 27672421    Free PMC article.
Review.
Photodynamic therapy induces interleukin secretion from dendritic cells.
Toshihiro Kushibiki, Takako Tajiri, Yutaka Tomioka, Kunio Awazu.
Int J Clin Exp Med, 2010 Jul 08; 3(2). PMID: 20607036    Free PMC article.
Photodamage to multiple Bcl-xL isoforms by photodynamic therapy with the phthalocyanine photosensitizer Pc 4.
Liang-yan Xue, Song-mao Chiu, +2 authors, Nancy L Oleinick.
Oncogene, 2003 Dec 19; 22(58). PMID: 14681679
Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma.
Abhishek D Garg, Lien Vandenberk, +4 authors, Patrizia Agostinis.
Sci Transl Med, 2016 Mar 05; 8(328). PMID: 26936504
Highly Cited.
Systemic immunosuppression induced by photodynamic therapy (PDT) is adoptively transferred by macrophages.
D H Lynch, S Haddad, +3 authors, C J Jolles.
Photochem Photobiol, 1989 Apr 01; 49(4). PMID: 2727085
Photodynamic therapy of murine mastocytoma induces specific immune responses against the cancer/testis antigen P1A.
Pawel Mroz, Fatma Vatansever, Angelika Muchowicz, Michael R Hamblin.
Cancer Res, 2013 Sep 28; 73(21). PMID: 24072749    Free PMC article.
Immunosuppressive effects of silicon phthalocyanine photodynamic therapy.
J C Reddan, C Y Anderson, +5 authors, C A Elmets.
Photochem Photobiol, 1999 Jul 27; 70(1). PMID: 10420845
Photodynamic therapy-induced apoptosis in lymphoma cells: translocation of cytochrome c causes inhibition of respiration as well as caspase activation.
M E Varnes, S M Chiu, L Y Xue, N L Oleinick.
Biochem Biophys Res Commun, 1999 Mar 02; 255(3). PMID: 10049769
Urinary cytokines following photodynamic therapy for bladder cancer. A preliminary report.
U O Nseyo, R K Whalen, +2 authors, S L Lundahl.
Urology, 1990 Aug 01; 36(2). PMID: 2117309
Photodynamic therapy-induced cell surface expression and release of heat shock proteins: relevance for tumor response.
Mladen Korbelik, Jinghai Sun, Ivana Cecic.
Cancer Res, 2005 Feb 12; 65(3). PMID: 15705903
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death.
Abhishek D Garg, Dmitri V Krysko, +12 authors, Patrizia Agostinis.
EMBO J, 2012 Jan 19; 31(5). PMID: 22252128    Free PMC article.
Highly Cited.
Vascular effects of photodynamic therapy.
B Krammer.
Anticancer Res, 2002 Mar 23; 21(6B). PMID: 11908681
Review.
Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells.
Nico Hendrickx, Cédric Volanti, +5 authors, Patrizia Agostinis.
J Biol Chem, 2003 Oct 15; 278(52). PMID: 14557269
Effective photoimmunotherapy of murine colon carcinoma induced by the combination of photodynamic therapy and dendritic cells.
Ahmad Jalili, Marcin Makowski, +15 authors, Jakub Gołab.
Clin Cancer Res, 2004 Jul 09; 10(13). PMID: 15240542
Inhibition of cyclooxygenase-2 indirectly potentiates antitumor effects of photodynamic therapy in mice.
Marcin Makowski, Tomasz Grzela, +11 authors, Jakub Gołab.
Clin Cancer Res, 2003 Nov 14; 9(14). PMID: 14614028
Evidence for an important role of neutrophils in the efficacy of photodynamic therapy in vivo.
W J de Vree, M C Essers, +3 authors, W Sluiter.
Cancer Res, 1996 Jul 01; 56(13). PMID: 8674038
Stimulation of dendritic cells by DAMPs in ALA-PDT treated SCC tumor cells.
Xiaojie Wang, Jie Ji, +7 authors, Xiuli Wang.
Oncotarget, 2015 Dec 02; 6(42). PMID: 26625309    Free PMC article.
The role of apoptosis in response to photodynamic therapy: what, where, why, and how.
Nancy L Oleinick, Rachel L Morris, Irina Belichenko.
Photochem Photobiol Sci, 2003 Mar 28; 1(1). PMID: 12659143
Highly Cited. Review.
Cyclooxygenase 2-mediated apoptotic and inflammatory responses in photodynamic therapy treated breast adenocarcinoma cells and xenografts.
Jiaxing Song, Yanchun Wei, Qun Chen, Da Xing.
J Photochem Photobiol B, 2014 May 06; 134. PMID: 24792472
Enhancement of colon carcinogenesis by prostaglandin E2 administration.
Toshihiko Kawamori, Naoaki Uchiya, Takashi Sugimura, Keiji Wakabayashi.
Carcinogenesis, 2003 May 29; 24(5). PMID: 12771044
Photodynamic therapy downregulates the function of regulatory T cells in patients with esophageal squamous cell carcinoma.
Eleonora Reginato, Jörg Lindenmann, +4 authors, Peter Wolf.
Photochem Photobiol Sci, 2014 Jul 10; 13(9). PMID: 25005268
Immunogenic cell death in cancer therapy.
Guido Kroemer, Lorenzo Galluzzi, Oliver Kepp, Laurence Zitvogel.
Annu Rev Immunol, 2012 Nov 20; 31. PMID: 23157435
Highly Cited. Review.
Photodynamic therapy-generated vaccine for cancer therapy.
Mladen Korbelik, Jinghai Sun.
Cancer Immunol Immunother, 2005 Oct 11; 55(8). PMID: 16215717
Generation of effective antitumor vaccines using photodynamic therapy.
Sandra O Gollnick, Lurine Vaughan, Barbara W Henderson.
Cancer Res, 2002 Mar 26; 62(6). PMID: 11912128
Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules.
Makoto Mitsunaga, Mikako Ogawa, +3 authors, Hisataka Kobayashi.
Nat Med, 2011 Nov 08; 17(12). PMID: 22057348    Free PMC article.
Highly Cited.
Photofrin photodynamic therapy can significantly deplete or preserve oxygenation in human basal cell carcinomas during treatment, depending on fluence rate.
B W Henderson, T M Busch, +9 authors, A R Oseroff.
Cancer Res, 2000 Feb 17; 60(3). PMID: 10676629
Autophagy in infection, inflammation and immunity.
Vojo Deretic, Tatsuya Saitoh, Shizuo Akira.
Nat Rev Immunol, 2013 Sep 26; 13(10). PMID: 24064518    Free PMC article.
Highly Cited. Review.
Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity.
Abhishek D Garg, Dominika Nowis, Jakub Golab, Patrizia Agostinis.
Apoptosis, 2010 Mar 12; 15(9). PMID: 20221698
Review.
Release of prostaglandin E2 from cells by photodynamic treatment in vitro.
B W Henderson, J M Donovan.
Cancer Res, 1989 Dec 15; 49(24 Pt 1). PMID: 2531034
Cell Death Pathways Associated with Photodynamic Therapy: An Update.
David Kessel, Nancy L Oleinick.
Photochem Photobiol, 2017 Nov 17; 94(2). PMID: 29143339
Review.
Photosensitizer-doped conjugated polymer nanoparticles with high cross-sections for one- and two-photon excitation.
Jennifer L Grimland, Changfeng Wu, +2 authors, Jason McNeill.
Nanoscale, 2011 Feb 05; 3(4). PMID: 21293789
Photochemical destruction of the Bcl-2 oncoprotein during photodynamic therapy with the phthalocyanine photosensitizer Pc 4.
L Y Xue, S M Chiu, N L Oleinick.
Oncogene, 2001 Jun 26; 20(26). PMID: 11423992
Treatment of Head and Neck Cancer with Photodynamic Therapy with Redaporfin: A Clinical Case Report.
Lúcio Lara Santos, Júlio Oliveira, +2 authors, Cristina Sarmento.
Case Rep Oncol, 2019 Jan 11; 11(3). PMID: 30627091    Free PMC article.
Enhanced Anti-Tumor Efficacy through a Combination of Integrin αvβ6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition.
Liquan Gao, Chenran Zhang, +6 authors, Zhaofei Liu.
Theranostics, 2016 Mar 30; 6(5). PMID: 27022411    Free PMC article.
The role of host lymphoid populations in the response of mouse EMT6 tumor to photodynamic therapy.
M Korbelik, G Krosl, J Krosl, G J Dougherty.
Cancer Res, 1996 Dec 15; 56(24). PMID: 8971170
Mreg Activity in Tumor Response to Photodynamic Therapy and Photodynamic Therapy-Generated Cancer Vaccines.
Mladen Korbelik, Judith Banáth, Wei Zhang.
Cancers (Basel), 2016 Oct 19; 8(10). PMID: 27754452    Free PMC article.
Apoptotic, but not necrotic, tumor cell vaccines induce a potent immune response in vivo.
Stephan R Scheffer, Heike Nave, +5 authors, Tim F Greten.
Int J Cancer, 2002 Nov 28; 103(2). PMID: 12455034
Near infrared photoimmunotherapy in the treatment of pleural disseminated NSCLC: preclinical experience.
Kazuhide Sato, Tadanobu Nagaya, Peter L Choyke, Hisataka Kobayashi.
Theranostics, 2015 Apr 22; 5(7). PMID: 25897335    Free PMC article.
Enhancing Anti-PD-1/PD-L1 Immune Checkpoint Inhibitory Cancer Therapy by CD276-Targeted Photodynamic Ablation of Tumor Cells and Tumor Vasculature.
Rui Bao, Yanpu Wang, +8 authors, Zhaofei Liu.
Mol Pharm, 2018 Nov 20; 16(1). PMID: 30452269
Elimination of primary tumours and control of metastasis with rationally designed bacteriochlorin photodynamic therapy regimens.
Luis B Rocha, Lígia C Gomes-da-Silva, Janusz M Dąbrowski, Luis G Arnaut.
Eur J Cancer, 2015 Jul 04; 51(13). PMID: 26139544
Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer.
Jieqi Ke, Yixia Yang, +12 authors, Xiaoping Wan.
Tumour Biol, 2016 Oct 27; 37(9). PMID: 27230680    Free PMC article.
Dendritic cells charged with apoptotic tumor cells induce long-lived protective CD4+ and CD8+ T cell immunity against B16 melanoma.
Romina S Goldszmid, Juliana Idoyaga, +3 authors, Rosa Wainstok.
J Immunol, 2003 Nov 25; 171(11). PMID: 14634105
Involvement of damage-associated molecular patterns in tumor response to photodynamic therapy: surface expression of calreticulin and high-mobility group box-1 release.
Mladen Korbelik, Wei Zhang, Soroush Merchant.
Cancer Immunol Immunother, 2011 Jun 07; 60(10). PMID: 21644033
Release of cytochrome c and activation of pro-caspase-9 following lysosomal photodamage involves Bid cleavage.
J J Reiners, J A Caruso, +3 authors, D Kessel.
Cell Death Differ, 2002 Aug 16; 9(9). PMID: 12181744    Free PMC article.
Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage.
Michael Dewaele, Wim Martinet, +4 authors, Patrizia Agostinis.
J Cell Mol Med, 2010 Jul 16; 15(6). PMID: 20626525    Free PMC article.
Induction of systemic neutrophil response in mice by photodynamic therapy of solid tumors.
I Cecic, C S Parkins, M Korbelik.
Photochem Photobiol, 2001 Nov 29; 74(5). PMID: 11723800
Prevention of late lumen loss after coronary angioplasty by photodynamic therapy: role of activated neutrophils.
W Sluiter, W J de Vree, A Pietersma, J F Koster.
Mol Cell Biochem, 1996 Apr 12; 157(1-2). PMID: 8739252
Review.
Systemic antitumor protection by vascular-targeted photodynamic therapy involves cellular and humoral immunity.
Dina Preise, Roni Oren, +4 authors, Yoram Salomon.
Cancer Immunol Immunother, 2008 May 20; 58(1). PMID: 18488222
Immunological and viral factors associated with the response of vulval intraepithelial neoplasia to photodynamic therapy.
E S Abdel-Hady, P Martin-Hirsch, +5 authors, I N Hampson.
Cancer Res, 2001 Feb 24; 61(1). PMID: 11196160
Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy.
Lorenzo Galluzzi, José Manuel Bravo-San Pedro, +2 authors, Guido Kroemer.
Nat Rev Clin Oncol, 2016 Nov 16; 14(4). PMID: 27845767
Highly Cited. Review.
Host Immunity Following Near-Infrared Photoimmunotherapy Is Enhanced with PD-1 Checkpoint Blockade to Eradicate Established Antigenic Tumors.
Tadanobu Nagaya, Jay Friedman, +6 authors, Hisataka Kobayashi.
Cancer Immunol Res, 2019 Jan 27; 7(3). PMID: 30683733    Free PMC article.
Photodynamic therapy induces rapid cell death by apoptosis in L5178Y mouse lymphoma cells.
M L Agarwal, M E Clay, +3 authors, N L Oleinick.
Cancer Res, 1991 Nov 01; 51(21). PMID: 1933862
Photodynamic therapy plus regulatory T-cell depletion produces immunity against a mouse tumour that expresses a self-antigen.
E Reginato, P Mroz, +3 authors, M R Hamblin.
Br J Cancer, 2013 Sep 26; 109(8). PMID: 24064977    Free PMC article.
Light-dependent oxygen consumption in bacteriochlorophyll-serine-treated melanoma tumors: on-line determination using a tissue-inserted oxygen microsensor.
J Zilberstein, A Bromberg, +5 authors, A Scherz.
Photochem Photobiol, 1997 Jun 01; 65(6). PMID: 9188281
CD8+ T cell-mediated control of distant tumours following local photodynamic therapy is independent of CD4+ T cells and dependent on natural killer cells.
E Kabingu, L Vaughan, +2 authors, S O Gollnick.
Br J Cancer, 2007 May 17; 96(12). PMID: 17505510    Free PMC article.
IL-17 promotes neutrophil entry into tumor-draining lymph nodes following induction of sterile inflammation.
Craig M Brackett, Jason B Muhitch, Sharon S Evans, Sandra O Gollnick.
J Immunol, 2013 Sep 13; 191(8). PMID: 24026079    Free PMC article.
EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival.
M Kamiyama, A Pozzi, +3 authors, P C Lin.
Oncogene, 2006 May 30; 25(53). PMID: 16732324
C5a fragment of bovine complement. Purification, bioassays, amino-acid sequence and other structural studies.
R Gennaro, T Simonic, +4 authors, D Romeo.
Eur J Biochem, 1986 Feb 17; 155(1). PMID: 3081348
Depletion of tumor oxygenation during photodynamic therapy: detection by the hypoxia marker EF3 [2-(2-nitroimidazol-1[H]-yl)-N-(3,3,3-trifluoropropyl)acetamide ].
T M Busch, S M Hahn, S M Evans, C J Koch.
Cancer Res, 2000 May 29; 60(10). PMID: 10825135
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4.
Ruth Scherz-Shouval, Elena Shvets, +3 authors, Zvulun Elazar.
EMBO J, 2007 Mar 10; 26(7). PMID: 17347651    Free PMC article.
Highly Cited.
Induction of NKG2D ligands and increased sensitivity of tumor cells to NK cell-mediated cytotoxicity by hematoporphyrin-based photodynamic therapy.
Min-Ju Park, Jae-Ho Bae, +2 authors, Chi-Dug Kang.
Immunol Invest, 2011 Feb 15; 40(4). PMID: 21314289
Acute phase response induction by cancer treatment with photodynamic therapy.
Mladen Korbelik, Ivana Cecic, Soroush Merchant, Jinghai Sun.
Int J Cancer, 2007 Nov 23; 122(6). PMID: 18033689
Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity.
Mikako Ogawa, Yusuke Tomita, +13 authors, Hisataka Kobayashi.
Oncotarget, 2017 Jan 07; 8(6). PMID: 28060726    Free PMC article.
Highly Cited.
Effects of Combined Lysosomal and Mitochondrial Photodamage in a Non-small-Cell Lung Cancer Cell Line: The Role of Paraptosis.
David Kessel, John J Reiners.
Photochem Photobiol, 2017 Jul 12; 93(6). PMID: 28696570    Free PMC article.
Mediators of peripheral blood neutrophilia induced by photodynamic therapy of solid tumors.
Ivana Cecic, Mladen Korbelik.
Cancer Lett, 2002 Jun 07; 183(1). PMID: 12049813
Myeloid-derived suppressor cells coming of age.
Filippo Veglia, Michela Perego, Dmitry Gabrilovich.
Nat Immunol, 2018 Jan 20; 19(2). PMID: 29348500    Free PMC article.
Highly Cited. Review.
Systemic Antitumor Immunity by PD-1/PD-L1 Inhibition Is Potentiated by Vascular-Targeted Photodynamic Therapy of Primary Tumors.
Matthew J O'Shaughnessy, Katie S Murray, +8 authors, Jonathan A Coleman.
Clin Cancer Res, 2017 Sep 29; 24(3). PMID: 28954788    Free PMC article.
Immunological aspects of antitumor photodynamic therapy outcome.
Małgorzata Wachowska, Angelika Muchowicz, Urszula Demkow.
Cent Eur J Immunol, 2016 Feb 11; 40(4). PMID: 26862314    Free PMC article.
Review.
Apoptotic pancreatic tumor cells are superior to cell lysates in promoting cross-priming of cytotoxic T cells and activate NK and gammadelta T cells.
Max Schnurr, Christoph Scholz, +5 authors, Andreas Eigler.
Cancer Res, 2002 Apr 17; 62(8). PMID: 11956095
Immunoregulatory Cell Depletion Improves the Efficacy of Photodynamic Therapy-Generated Cancer Vaccines.
Mladen Korbelik, Judit Banáth, Kyi Min Saw.
Int J Mol Sci, 2015 Nov 17; 16(11). PMID: 26569233    Free PMC article.
Photodynamic therapy of cancer: an update.
Patrizia Agostinis, Kristian Berg, +14 authors, Jakub Golab.
CA Cancer J Clin, 2011 May 28; 61(4). PMID: 21617154    Free PMC article.
Highly Cited. Review.
Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model.
Ana P Castano, Pawel Mroz, Mei X Wu, Michael R Hamblin.
Proc Natl Acad Sci U S A, 2008 Apr 02; 105(14). PMID: 18378905    Free PMC article.
Apoptosis, Paraptosis and Autophagy: Death and Survival Pathways Associated with Photodynamic Therapy.
David Kessel.
Photochem Photobiol, 2018 Jun 09; 95(1). PMID: 29882356    Free PMC article.
Review.
Photodynamic therapy induces expression of interleukin 6 by activation of AP-1 but not NF-kappa B DNA binding.
G Kick, G Messer, +2 authors, P Kind.
Cancer Res, 1995 Jun 01; 55(11). PMID: 7757989
Photodynamic-therapy-activated immune response against distant untreated tumours in recurrent angiosarcoma.
Patricia Soo-Ping Thong, Kong-Wee Ong, +5 authors, Khee-Chee Soo.
Lancet Oncol, 2007 Oct 05; 8(10). PMID: 17913664
Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation.
Abhishek D Garg, Dominika Nowis, +3 authors, Patrizia Agostinis.
Biochim Biophys Acta, 2009 Sep 02; 1805(1). PMID: 19720113
Highly Cited. Review.
A requirement for bid for induction of apoptosis by photodynamic therapy with a lysosome- but not a mitochondrion-targeted photosensitizer.
Song-Mao Chiu, Liang-Yan Xue, +5 authors, Nancy L Oleinick.
Photochem Photobiol, 2010 Jun 18; 86(5). PMID: 20553412    Free PMC article.
Role of the immune system in mediating the antitumor effect of benzophenothiazine photodynamic therapy.
J A Hendrzak-Henion, T L Knisely, +2 authors, A H Cincotta.
Photochem Photobiol, 1999 May 20; 69(5). PMID: 10333764
Studies expand potential uses of photodynamic therapy.
Gail McBride.
J Natl Cancer Inst, 2002 Dec 05; 94(23). PMID: 12464643
The effect of photodynamic therapy on tumor cell expression of major histocompatibility complex (MHC) class I and MHC class I-related molecules.
Alan Belicha-Villanueva, Jonah Riddell, Naveen Bangia, Sandra O Gollnick.
Lasers Surg Med, 2012 Jan 17; 44(1). PMID: 22246985    Free PMC article.
Vascular accumulation of a novel photosensitizer, MV6401, causes selective thrombosis in tumor vessels after photodynamic therapy.
Dennis E J G J Dolmans, Ananth Kadambi, +5 authors, Rakesh K Jain.
Cancer Res, 2002 Apr 04; 62(7). PMID: 11929837
Direct tumor damage mechanisms of photodynamic therapy.
Dominika Nowis, Marcin Makowski, +3 authors, Jakub Gołab.
Acta Biochim Pol, 2005 Jul 02; 52(2). PMID: 15990919
Review.
DAMPs, PAMPs and alarmins: all we need to know about danger.
Marco E Bianchi.
J Leukoc Biol, 2006 Oct 13; 81(1). PMID: 17032697
Highly Cited. Review.
Fluence rate effects in photodynamic therapy of multicell tumor spheroids.
T H Foster, D F Hartley, M G Nichols, R Hilf.
Cancer Res, 1993 Mar 15; 53(6). PMID: 8443805
Hematoporphyrin derivative for detection and management of cancer.
R L Lipson, E J Baldes, M J Gray.
Cancer, 1967 Dec 01; 20(12). PMID: 6073903
Primary sterile necrotic cells fail to cross-prime CD8(+) T cells.
Jaba Gamrekelashvili, Lars A Ormandy, +4 authors, Tim F Greten.
Oncoimmunology, 2012 Nov 22; 1(7). PMID: 23170250    Free PMC article.
PGE2 induced in and released by dying cells functions as an inhibitory DAMP.
Sho Hangai, Tomoka Ao, +7 authors, Hideyuki Yanai.
Proc Natl Acad Sci U S A, 2016 Mar 24; 113(14). PMID: 27001836    Free PMC article.
The autophagosome: origins unknown, biogenesis complex.
Christopher A Lamb, Tamotsu Yoshimori, Sharon A Tooze.
Nat Rev Mol Cell Biol, 2013 Nov 10; 14(12). PMID: 24201109
Highly Cited. Review.
Enhanced systemic immune reactivity to a Basal cell carcinoma associated antigen following photodynamic therapy.
Edith Kabingu, Allan R Oseroff, Gregory E Wilding, Sandra O Gollnick.
Clin Cancer Res, 2009 Jun 25; 15(13). PMID: 19549769    Free PMC article.
Photodynamic therapy enhancement of antitumor immunity is regulated by neutrophils.
Philaretos C Kousis, Barbara W Henderson, Patricia G Maier, Sandra O Gollnick.
Cancer Res, 2007 Nov 03; 67(21). PMID: 17974994    Free PMC article.
Photodynamic therapy and cell death pathways.
David Kessel, Nancy L Oleinick.
Methods Mol Biol, 2010 Jun 17; 635. PMID: 20552338    Free PMC article.
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.
Santiago Zelenay, Annemarthe G van der Veen, +9 authors, Caetano Reis e Sousa.
Cell, 2015 Sep 08; 162(6). PMID: 26343581    Free PMC article.
Highly Cited.
Photodynamic therapy of tumors can lead to development of systemic antigen-specific immune response.
Pawel Mroz, Angelika Szokalska, Mei X Wu, Michael R Hamblin.
PLoS One, 2010 Dec 24; 5(12). PMID: 21179470    Free PMC article.
Nitric oxide-elicited resistance to anti-glioblastoma photodynamic therapy.
Albert W Girotti, Jonathan M Fahey, Witold Korytowski.
Cancer Drug Resist, 2020 Oct 20; 3(3). PMID: 33073206    Free PMC article.
NIR-Absorbing RuII Complexes Containing α-Oligothiophenes for Applications in Photodynamic Therapy.
Liubov M Lifshits, John A Roque, +3 authors, Sherri A McFarland.
Chembiochem, 2020 Aug 08; 21(24). PMID: 32761725    Free PMC article.
Tumor cytotoxicity and immunogenicity of a novel V-jet neon plasma source compared to the kINPen.
Lea Miebach, Eric Freund, +9 authors, Sander Bekeschus.
Sci Rep, 2021 Jan 10; 11(1). PMID: 33420228    Free PMC article.
Negative effects of tumor cell nitric oxide on anti-glioblastoma photodynamic therapy.
Albert W Girotti, Jonathan M Fahey, Witold Korytowski.
J Cancer Metastasis Treat, 2021 Feb 11; 6. PMID: 33564720    Free PMC article.
Membrane engineering of cell membrane biomimetic nanoparticles for nanoscale therapeutics.
Minghai Zhang, Shanshan Cheng, +2 authors, Yu Wang.
Clin Transl Med, 2021 Feb 27; 11(2). PMID: 33635002    Free PMC article.
Review.
Enhancement of innate and adaptive anti-tumor immunity by serum obtained from vascular photodynamic therapy-cured BALB/c mouse.
Ying Zhang, Ying-Kit Cheung, Dennis K P Ng, Wing-Ping Fong.
Cancer Immunol Immunother, 2021 Apr 07; 70(11). PMID: 33821298
Near-infrared absorbing Ru(ii) complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma.
Liubov M Lifshits, John A Roque Iii, +9 authors, Sherri A McFarland.
Chem Sci, 2021 May 13; 11(43). PMID: 33976756    Free PMC article.
Current Prospects for Treatment of Solid Tumors via Photodynamic, Photothermal, or Ionizing Radiation Therapies Combined with Immune Checkpoint Inhibition (A Review).
Sanjay Anand, Timothy A Chan, Tayyaba Hasan, Edward V Maytin.
Pharmaceuticals (Basel), 2021 Jun 03; 14(5). PMID: 34068491    Free PMC article.
Review.
Nanotechnology assisted photo- and sonodynamic therapy for overcoming drug resistance.
Rui Li, Zhimin Chen, Zhifei Dai, Yingjie Yu.
Cancer Biol Med, 2021 Mar 24;. PMID: 33755377    Free PMC article.
Review.
Insight into the Web of Stress Responses Triggered at Gene Expression Level by Porphyrin-PDT in HT29 Human Colon Carcinoma Cells.
Maria Dobre, Rica Boscencu, +3 authors, Gina Manda.
Pharmaceutics, 2021 Aug 11; 13(7). PMID: 34371724    Free PMC article.
Inhibition of photodynamic therapy induced-immunosuppression with aminolevulinic acid leads to enhanced outcomes of tumors and pre-cancerous lesions.
Sharlo Bayless, Jeffrey B Travers, Ravi P Sahu, Craig A Rohan.
Oncol Lett, 2021 Aug 14; 22(3). PMID: 34386086    Free PMC article.
Review.
Photodynamic Therapy Induced Cell Death Mechanisms in Breast Cancer.
Dimakatso R Mokoena, Blassan P George, Heidi Abrahamse.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34638847    Free PMC article.
Review.
ROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities.
Sanjeev Kumar Sagwal, Sander Bekeschus.
Oxid Med Cell Longev, 2021 Nov 16; 2021. PMID: 34777692    Free PMC article.
Review.
Hemagglutinin Nanoparticulate Vaccine with Controlled Photochemical Immunomodulation for Pathogenic Influenza-Specific Immunity.
Hayoon Jeong, Chung-Sung Lee, +4 authors, Kun Na.
Adv Sci (Weinh), 2021 Oct 26; 8(23). PMID: 34693665    Free PMC article.
Current Photoactive Molecules for Targeted Therapy of Triple-Negative Breast Cancer.
Cristina J Dias, Luisa Helguero, Maria Amparo F Faustino.
Molecules, 2021 Dec 25; 26(24). PMID: 34946732    Free PMC article.
Review.
Combinatorial Therapeutic Approaches with Nanomaterial-Based Photodynamic Cancer Therapy.
Yang Hao, Chih Kit Chung, +4 authors, Luis J Cruz.
Pharmaceutics, 2022 Jan 22; 14(1). PMID: 35057015    Free PMC article.
Review.
Photodynamic therapy of melanoma with new, structurally similar, NIR-absorbing ruthenium (II) complexes promotes tumor growth control via distinct hallmarks of immunogenic cell death.
Prathyusha Konda, John A Roque Iii, +6 authors, Shashi Gujar.
Am J Cancer Res, 2022 Feb 11; 12(1). PMID: 35141014    Free PMC article.
HSA-Binding Prodrugs-Based Nanoparticles Endowed with Chemo and Photo-Toxicity against Breast Cancer.
Valentina Rapozzi, Francesca Moret, +11 authors, Greta Varchi.
Cancers (Basel), 2022 Feb 26; 14(4). PMID: 35205627    Free PMC article.
Photodynamic Theranostics of Central Lung Cancer: Capabilities of Early Diagnosis and Minimally Invasive Therapy (Review).
G V Papayan, A L Akopov.
Sovrem Tekhnologii Med, 2021 Jan 01; 13(6). PMID: 35265362    Free PMC article.
Review.
Two Beats One: Osteosarcoma Therapy with Light-Activated and Chemo-Releasing Keratin Nanoformulation in a Preclinical Mouse Model.
Elisa Martella, Barbara Dozza, +12 authors, Serena Duchi.
Pharmaceutics, 2022 Mar 27; 14(3). PMID: 35336051    Free PMC article.
Intraligand Excited States Turn a Ruthenium Oligothiophene Complex into a Light-Triggered Ubertoxin with Anticancer Effects in Extreme Hypoxia.
John A Roque Iii, Houston D Cole, +8 authors, Sherri A McFarland.
J Am Chem Soc, 2022 Apr 29; 144(18). PMID: 35482975    Free PMC article.
Ring-Fused meso-Tetraarylchlorins as Auspicious PDT Sensitizers: Synthesis, Structural Characterization, Photophysics, and Biological Evaluation.
Mafalda Laranjo, Nelson A M Pereira, +10 authors, Teresa M V D Pinho E Melo.
Front Chem, 2022 May 17; 10. PMID: 35572112    Free PMC article.