. 2020 Mar; 96(3):550-559.
doi: 10.1111/php.13253.

Photodynamic Therapy and Immunity: An Update

Riddhi Falk-Mahapatra 1 Sandra O Gollnick 1 
  • PMID: 32128821
  •     121 References
  •     22 citations


Dr. Thomas Dougherty and his Oncology Foundation of Buffalo were the first to support my (S.O.G.) research into the effects of photodynamic therapy (PDT) on the host immune system. The small grant I was awarded in 2002 launched my career as an independent researcher; at the time, there were few studies on the importance of the immune response on the efficacy of PDT and no studies demonstrating the ability of PDT to enhance antitumor immunity. Over the last decades, the interest in PDT as an enhancer of antitumor immunity and our understanding of the mechanisms by which PDT enhances antitumor immunity have dramatically increased. In this review article, we look back on the studies that laid the foundation for our understanding and provide an update on current advances and therapies that take advantage of PDT enhancement of immunity.

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Nat Rev Mol Cell Biol, 2013 Nov 10; 14(12). PMID: 24201109
Highly Cited. Review.
Enhanced systemic immune reactivity to a Basal cell carcinoma associated antigen following photodynamic therapy.
Edith Kabingu, Allan R Oseroff, Gregory E Wilding, Sandra O Gollnick.
Clin Cancer Res, 2009 Jun 25; 15(13). PMID: 19549769    Free PMC article.
Photodynamic therapy enhancement of antitumor immunity is regulated by neutrophils.
Philaretos C Kousis, Barbara W Henderson, Patricia G Maier, Sandra O Gollnick.
Cancer Res, 2007 Nov 03; 67(21). PMID: 17974994    Free PMC article.
Photodynamic therapy and cell death pathways.
David Kessel, Nancy L Oleinick.
Methods Mol Biol, 2010 Jun 17; 635. PMID: 20552338    Free PMC article.
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.
Santiago Zelenay, Annemarthe G van der Veen, +9 authors, Caetano Reis e Sousa.
Cell, 2015 Sep 08; 162(6). PMID: 26343581    Free PMC article.
Highly Cited.
Photodynamic therapy of tumors can lead to development of systemic antigen-specific immune response.
Pawel Mroz, Angelika Szokalska, Mei X Wu, Michael R Hamblin.
PLoS One, 2010 Dec 24; 5(12). PMID: 21179470    Free PMC article.
Nitric oxide-elicited resistance to anti-glioblastoma photodynamic therapy.
Albert W Girotti, Jonathan M Fahey, Witold Korytowski.
Cancer Drug Resist, 2020 Oct 20; 3(3). PMID: 33073206    Free PMC article.
NIR-Absorbing RuII Complexes Containing α-Oligothiophenes for Applications in Photodynamic Therapy.
Liubov M Lifshits, John A Roque, +3 authors, Sherri A McFarland.
Chembiochem, 2020 Aug 08; 21(24). PMID: 32761725    Free PMC article.
Tumor cytotoxicity and immunogenicity of a novel V-jet neon plasma source compared to the kINPen.
Lea Miebach, Eric Freund, +9 authors, Sander Bekeschus.
Sci Rep, 2021 Jan 10; 11(1). PMID: 33420228    Free PMC article.
Negative effects of tumor cell nitric oxide on anti-glioblastoma photodynamic therapy.
Albert W Girotti, Jonathan M Fahey, Witold Korytowski.
J Cancer Metastasis Treat, 2021 Feb 11; 6. PMID: 33564720    Free PMC article.
Membrane engineering of cell membrane biomimetic nanoparticles for nanoscale therapeutics.
Minghai Zhang, Shanshan Cheng, +2 authors, Yu Wang.
Clin Transl Med, 2021 Feb 27; 11(2). PMID: 33635002    Free PMC article.
Enhancement of innate and adaptive anti-tumor immunity by serum obtained from vascular photodynamic therapy-cured BALB/c mouse.
Ying Zhang, Ying-Kit Cheung, Dennis K P Ng, Wing-Ping Fong.
Cancer Immunol Immunother, 2021 Apr 07; 70(11). PMID: 33821298
Near-infrared absorbing Ru(ii) complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma.
Liubov M Lifshits, John A Roque Iii, +9 authors, Sherri A McFarland.
Chem Sci, 2021 May 13; 11(43). PMID: 33976756    Free PMC article.
Current Prospects for Treatment of Solid Tumors via Photodynamic, Photothermal, or Ionizing Radiation Therapies Combined with Immune Checkpoint Inhibition (A Review).
Sanjay Anand, Timothy A Chan, Tayyaba Hasan, Edward V Maytin.
Pharmaceuticals (Basel), 2021 Jun 03; 14(5). PMID: 34068491    Free PMC article.
Nanotechnology assisted photo- and sonodynamic therapy for overcoming drug resistance.
Rui Li, Zhimin Chen, Zhifei Dai, Yingjie Yu.
Cancer Biol Med, 2021 Mar 24;. PMID: 33755377    Free PMC article.
Insight into the Web of Stress Responses Triggered at Gene Expression Level by Porphyrin-PDT in HT29 Human Colon Carcinoma Cells.
Maria Dobre, Rica Boscencu, +3 authors, Gina Manda.
Pharmaceutics, 2021 Aug 11; 13(7). PMID: 34371724    Free PMC article.
Inhibition of photodynamic therapy induced-immunosuppression with aminolevulinic acid leads to enhanced outcomes of tumors and pre-cancerous lesions.
Sharlo Bayless, Jeffrey B Travers, Ravi P Sahu, Craig A Rohan.
Oncol Lett, 2021 Aug 14; 22(3). PMID: 34386086    Free PMC article.
Photodynamic Therapy Induced Cell Death Mechanisms in Breast Cancer.
Dimakatso R Mokoena, Blassan P George, Heidi Abrahamse.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34638847    Free PMC article.
ROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities.
Sanjeev Kumar Sagwal, Sander Bekeschus.
Oxid Med Cell Longev, 2021 Nov 16; 2021. PMID: 34777692    Free PMC article.
Hemagglutinin Nanoparticulate Vaccine with Controlled Photochemical Immunomodulation for Pathogenic Influenza-Specific Immunity.
Hayoon Jeong, Chung-Sung Lee, +4 authors, Kun Na.
Adv Sci (Weinh), 2021 Oct 26; 8(23). PMID: 34693665    Free PMC article.
Current Photoactive Molecules for Targeted Therapy of Triple-Negative Breast Cancer.
Cristina J Dias, Luisa Helguero, Maria Amparo F Faustino.
Molecules, 2021 Dec 25; 26(24). PMID: 34946732    Free PMC article.
Combinatorial Therapeutic Approaches with Nanomaterial-Based Photodynamic Cancer Therapy.
Yang Hao, Chih Kit Chung, +4 authors, Luis J Cruz.
Pharmaceutics, 2022 Jan 22; 14(1). PMID: 35057015    Free PMC article.
Photodynamic therapy of melanoma with new, structurally similar, NIR-absorbing ruthenium (II) complexes promotes tumor growth control via distinct hallmarks of immunogenic cell death.
Prathyusha Konda, John A Roque Iii, +6 authors, Shashi Gujar.
Am J Cancer Res, 2022 Feb 11; 12(1). PMID: 35141014    Free PMC article.
HSA-Binding Prodrugs-Based Nanoparticles Endowed with Chemo and Photo-Toxicity against Breast Cancer.
Valentina Rapozzi, Francesca Moret, +11 authors, Greta Varchi.
Cancers (Basel), 2022 Feb 26; 14(4). PMID: 35205627    Free PMC article.
Photodynamic Theranostics of Central Lung Cancer: Capabilities of Early Diagnosis and Minimally Invasive Therapy (Review).
G V Papayan, A L Akopov.
Sovrem Tekhnologii Med, 2021 Jan 01; 13(6). PMID: 35265362    Free PMC article.
Two Beats One: Osteosarcoma Therapy with Light-Activated and Chemo-Releasing Keratin Nanoformulation in a Preclinical Mouse Model.
Elisa Martella, Barbara Dozza, +12 authors, Serena Duchi.
Pharmaceutics, 2022 Mar 27; 14(3). PMID: 35336051    Free PMC article.
Intraligand Excited States Turn a Ruthenium Oligothiophene Complex into a Light-Triggered Ubertoxin with Anticancer Effects in Extreme Hypoxia.
John A Roque Iii, Houston D Cole, +8 authors, Sherri A McFarland.
J Am Chem Soc, 2022 Apr 29; 144(18). PMID: 35482975    Free PMC article.
Ring-Fused meso-Tetraarylchlorins as Auspicious PDT Sensitizers: Synthesis, Structural Characterization, Photophysics, and Biological Evaluation.
Mafalda Laranjo, Nelson A M Pereira, +10 authors, Teresa M V D Pinho E Melo.
Front Chem, 2022 May 17; 10. PMID: 35572112    Free PMC article.