A new clinical-genomic model to predict 10-year recurrence risk in primary operable breast cancer patients

Tzu-Ting Huang ¹, Lei Lei ², Ching-Hsuan Andre Chen ³, Tzu-Pin Lu ³, Chung-Wen Jen ⁴, Skye Hung-Chun Cheng ⁵

Affiliations

¹ Department of Research, Koo Foundation, Sun Yat-Sen Cancer Center, Taipei, Taiwan.
² Department of Breast Medical Oncology, Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), ZheJiang, China.
³ Epidemiology and Preventive Medicine, Department of Public Health, National Taiwan University, Taipei, Taiwan.
⁴ Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
⁵ Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan. skyecheng@gmail.com.

PMID: 32184406
29 References

Abstract

This study aimed to validate the long-term prognostic value of a new clinical-genomic model, Distant Genetic Model-Clinical Variable Model 6 (DGM-CM6), developed in Asia as a prognostic panel for all subtypes of breast cancer. We included 752 operable stage I-III breast cancer patients representing all subtypes treated from 2005 to 2014 as the validation cohort. The median follow-up was 95.8 months. The low- and high-risk patients classified by DGM-CM6 (RI-DR) had significant differences in 10-year distant recurrence-free interval (DRFI) (94.1% vs. 85.0%, P < 0.0001) and relapse-free survival (RFS) (90.0% vs. 80.5%, P = 0.0003). External validation using EMTAB-365 dataset showed similar observation (P < 0.0001). DGM-CM6 was an independent prognostic factor by multivariate analysis with hazard ratios of 3.1 (1.6-6.0) for RFS (P = 0.0009) and 3.8 (1.6-9.0) for DRFI (P = 0.0028). Comparing the C-index of DGM-CM6 and PAM50-ROR scores, the former performed better than the latter in predicting long-term DRFI and RFS, especially in N0, ER/PR-positive, and HER2-negative patients.

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References

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