Review
. 2020 Apr; 48(2):595-612.
doi: 10.1042/BST20190854.

MicroRNAs and long non-coding RNAs as novel regulators of ribosome biogenesis

Mason A McCool 1 Carson J Bryant 1 Susan J Baserga 1 
Affiliations
  • PMID: 32267487
  •     109 References
  •     4 citations

Abstract

Ribosome biogenesis is the fine-tuned, essential process that generates mature ribosomal subunits and ultimately enables all protein synthesis within a cell. Novel regulators of ribosome biogenesis continue to be discovered in higher eukaryotes. While many known regulatory factors are proteins or small nucleolar ribonucleoproteins, microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) are emerging as a novel modulatory layer controlling ribosome production. Here, we summarize work uncovering non-coding RNAs (ncRNAs) as novel regulators of ribosome biogenesis and highlight their links to diseases of defective ribosome biogenesis. It is still unclear how many miRNAs or lncRNAs are involved in phenotypic or pathological disease outcomes caused by impaired ribosome production, as in the ribosomopathies, or by increased ribosome production, as in cancer. In time, we hypothesize that many more ncRNA regulators of ribosome biogenesis will be discovered, which will be followed by an effort to establish connections between disease pathologies and the molecular mechanisms of this additional layer of ribosome biogenesis control.

Keywords: cancer; gene regulation; non-coding RNA; nucleolus; ribosomopathies.

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Cecelia M Harold, Amber F Buhagiar, Yan Cheng, Susan J Baserga.
Genes (Basel), 2021 Apr 04; 12(4). PMID: 33805424    Free PMC article.
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Exon-Intron Differential Analysis Reveals the Role of Competing Endogenous RNAs in Post-Transcriptional Regulation of Translation.
Nicolas Munz, Luciano Cascione, +7 authors, Sara Napoli.
Noncoding RNA, 2021 May 01; 7(2). PMID: 33923420    Free PMC article.