Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma

Xin-Ying Li ¹, Liu-Chang Tan ¹, Li-Wen Dong ¹, Wan-Qi Zhang ¹, Xiao-Xiao Shen ¹, Xiao Lu ², Hong Zheng ², Yuan-Gang Lu ¹

Affiliations

¹ Department of Plastic Surgery, Daping Hospital, Army Medical University, Chongqing, China.
² Department of Thoracic Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China.

PMID: 32528867
199 References
7 citations

Abstract

Melanoma is the most aggressive malignant skin tumor and arises from melanocytes. The resistance of melanoma cells to various treatments results in rapid tumor growth and high mortality. As a local therapeutic modality, photodynamic therapy has been successfully applied for clinical treatment of skin diseases. Photodynamic therapy is a relatively new treatment method for various types of malignant tumors in humans and, compared to conventional treatment methods, has fewer side effects, and is more accurate and non-invasive. Although several in vivo and in vitro studies have shown encouraging results regarding the potential benefits of photodynamic therapy as an adjuvant treatment for melanoma, its clinical application remains limited owing to its relative inefficiency. This review article discusses the use of photodynamic therapy in melanoma treatment as well as the latest progress made in deciphering the mechanism of tolerance. Lastly, potential targets are identified that may improve photodynamic therapy against melanoma cells.

Keywords: apoptosis; autophagy; melanoma; photodynamic therapy; tumor immunity.

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References
Killing efficacy of a new silicon phthalocyanine in human melanoma cells treated with photodynamic therapy by early activation of mitochondrion-mediated apoptosis. Jérôme Barge, Richard Decréau, +4 authors, Patrick Verrando. less Exp Dermatol, 2004 Mar 11; 13(1). PMID: 15009114
Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses. Dong Sun Oh, Heegon Kim, +4 authors, Heung Kyu Lee. less Oncotarget, 2017 May 26; 8(29). PMID: 28537894 Free PMC article.
Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Huayi Wang, Liming Sun, +5 authors, Xiaodong Wang. less Mol Cell, 2014 Apr 08; 54(1). PMID: 24703947 Highly Cited.
PDT-associated host response and its role in the therapy outcome. Mladen Korbelik. Lasers Surg Med, 2006 Apr 25; 38(5). PMID: 16634073 Review.
In vitro photodynamic therapy on melanoma cell lines with phthalocyanine. H Kolarova, P Nevrelova, +3 authors, R Bajgar, D Jirova, K Kejlova, M Strnad. less Toxicol In Vitro, 2006 Nov 10; 21(2). PMID: 17092686
Inhibition of lymphangiogenesis impairs antitumour effects of photodynamic therapy and checkpoint inhibitors in mice. Angelika Muchowicz, Malgorzata Wachowska, +8 authors, Jakub Golab. less Eur J Cancer, 2017 Jul 15; 83. PMID: 28709135
Fighting cancer by attacking its blood supply. J Folkman. Sci Am, 1996 Sep 01; 275(3). PMID: 8701285 Review.
Autophagy- An emerging target for melanoma therapy. Abibatou Ndoye, Ashani T Weeraratna. F1000Res, 2016 Sep 02; 5. PMID: 27583134 Free PMC article. Review.
Effects of BAPTA-AM, Forskolin, DSF and Z.VAD.fmk on PDT-induced apoptosis and m-THPC phototoxicity on B16 cells. S Thibaut, L Bourré, +3 authors, D Hernot, N Rousset, Y Lajat, T Patrice. less Apoptosis, 2002 Feb 28; 7(2). PMID: 11865193
Targeting autophagy to overcome chemoresistance in acute myleogenous leukemia. Sujan Piya, Michael Andreeff, Gautam Borthakur. Autophagy, 2016 Nov 01; 13(1). PMID: 27797294 Free PMC article.
Can nanotechnology potentiate photodynamic therapy? Ying-Ying Huang, Sulbha K Sharma, +6 authors, Michael R Hamblin. less Nanotechnol Rev, 2012 Mar 01; 1(2). PMID: 26361572 Free PMC article.
Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation. Nina Germic, Ziva Frangez, Shida Yousefi, Hans-Uwe Simon. Cell Death Differ, 2019 Feb 10; 26(4). PMID: 30737475 Free PMC article. Highly Cited. Review.
Poly(N-phenylglycine)-Based Nanoparticles as Highly Effective and Targeted Near-Infrared Photothermal Therapy/Photodynamic Therapeutic Agents for Malignant Melanoma. Bang-Ping Jiang, Li Zhang, +4 authors, Hong Liang. less Small, 2016 Dec 17; 13(8). PMID: 27982516
In vitro and in vivo photosensitizing applications of Photofrin in malignant melanoma cells. Cheng-Jen Chang, Jau-Song Yu, Fu-Chan Wei. Chang Gung Med J, 2008 Sep 12; 31(3). PMID: 18782948
Treatment of amelanotic choroidal melanoma with photodynamic therapy. William G Campbell, Tanya M Pejnovic. Retina, 2011 Dec 08; 32(7). PMID: 22146128
Verteporfin-loaded mesoporous silica nanoparticles inhibit mouse melanoma proliferation in vitro and in vivo. Nausicaa Clemente, Ivana Miletto, +4 authors, Filippo Renò. less J Photochem Photobiol B, 2019 Jun 30; 197. PMID: 31254952
Mitochondrial signaling in cell death via the Bcl-2 family. Brian Leibowitz, Jian Yu. Cancer Biol Ther, 2010 Mar 02; 9(6). PMID: 20190564 Free PMC article. Review.
Biodegradable nanocomplex from hyaluronic acid and arginine based poly(ester amide)s as the delivery vehicles for improved photodynamic therapy of multidrug resistant tumor cells: An in vitro study of the performance of chlorin e6 photosensitizer. Ying Ji, Jihui Zhao, Chih-Chang Chu. J Biomed Mater Res A, 2016 Dec 21; 105(5). PMID: 27997760
Molecular response to hypericin-induced photodamage. B Krammer, T Verwanger. Curr Med Chem, 2012 Jan 05; 19(6). PMID: 22214453 Review.
PHOTODYNAMIC THERAPY AS PRIMARY TREATMENT FOR SMALL CHOROIDAL MELANOMA. Elif B Turkoglu, Renelle Pointdujour-Lim, Arman Mashayekhi, Carol L Shields. Retina, 2018 Apr 17; 39(7). PMID: 29659412
Assessing autophagy in the context of photodynamic therapy. John J Reiners, Patrizia Agostinis, +2 authors, Kristian Berg, Nancy L Oleinick, David Kessel. less Autophagy, 2009 Oct 27; 6(1). PMID: 19855190 Free PMC article. Review.
Photodynamic therapy on skin melanoma and epidermoid carcinoma cells using conjugated 5-aminolevulinic acid with microbial synthesised silver nanoparticles. Aishwarya Shivashankarappa, Konasur Rajesh Sanjay. J Drug Target, 2018 Oct 04; 27(4). PMID: 30281374
Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Joon-Ho Sheen, Roberto Zoncu, Dohoon Kim, David M Sabatini. Cancer Cell, 2011 May 18; 19(5). PMID: 21575862 Free PMC article. Highly Cited.
Therapeutic effects of topical 5-aminolevulinic acid photodynamic therapy. Yin-E Hu, Shu-Fang Dai, +2 authors, Bin Wang, Wei Qu, Jun-Ling Gao. less Pak J Med Sci, 2016 Sep 21; 32(4). PMID: 27648048 Free PMC article.
Heat shock proteins regulates cardiomyocytes via Toll-like receptors. Kenta Terai, Naoki Mochizuki. Circ J, 2011 Aug 06; 75(10). PMID: 21817812
Upregulation of autophagy-related gene-5 (ATG-5) is associated with chemoresistance in human gastric cancer. Jie Ge, Zihua Chen, +4 authors, Zhikang Chen. less PLoS One, 2014 Oct 21; 9(10). PMID: 25329677 Free PMC article.
Ready player one? Autophagy shapes resistance to photodynamic therapy in cancers. Xian Duan, Bo Chen, +8 authors, Jun He. less Apoptosis, 2018 Oct 06; 23(11-12). PMID: 30288638 Review.
DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis. Wynand P Roos, Bernd Kaina. Cancer Lett, 2012 Jan 21; 332(2). PMID: 22261329 Highly Cited. Review.
Differential effects of N-TiO2 nanoparticle and its photo-activated form on autophagy and necroptosis in human melanoma A375 cells. Zahra Mohammadalipour, Marveh Rahmati, Alireza Khataee, Mohammad A Moosavi. J Cell Physiol, 2020 Jan 29; 235(11). PMID: 31989650
In situ photoimmunotherapy: a tumour-directed treatment for melanoma. M F Naylor, W R Chen, +2 authors, T K Teague, L A Perry, R E Nordquist. less Br J Dermatol, 2006 Nov 17; 155(6). PMID: 17107404
Immunogenic cell death due to a new photodynamic therapy (PDT) with glycoconjugated chlorin (G-chlorin). Mamoru Tanaka, Hiromi Kataoka, +14 authors, Takashi Joh. less Oncotarget, 2016 Jul 01; 7(30). PMID: 27363018 Free PMC article.
Simulated Sunlight-Mediated Photodynamic Therapy for Melanoma Skin Cancer by Titanium-Dioxide-Nanoparticle-Gold-Nanocluster-Graphene Heterogeneous Nanocomposites. Yan Cheng, Yun Chang, +5 authors, Haiyuan Zhang. less Small, 2017 Apr 04; 13(20). PMID: 28371113
Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells. Cheng-Fei Li, Jia-Xing Sun, +4 authors, Xi-Qing Sun. less Cell Death Dis, 2018 Feb 06; 9(2). PMID: 29396411 Free PMC article.
Autophagy in aging, disease and death: the true identity of a cell death impostor. B Levine, G Kroemer. Cell Death Differ, 2008 Dec 17; 16(1). PMID: 19079285 Free PMC article.
The influence of photodynamic therapy on apoptosis in human melanoma cell line. J Saczko, J Kulbacka, +4 authors, T Banaś. less Folia Histochem Cytobiol, 2005 Oct 06; 43(3). PMID: 16201311
Magnetic and pH dual-responsive mesoporous silica nanocomposites for effective and low-toxic photodynamic therapy. Jieqiong Zhan, Zhiqiang Ma, +7 authors, Feng Yang. less Int J Nanomedicine, 2017 Apr 27; 12. PMID: 28442903 Free PMC article.
Clinical effects of in situ photoimmunotherapy on late-stage melanoma patients: a preliminary study. Xiaosong Li, Mark F Naylor, +5 authors, Wei R Chen. less Cancer Biol Ther, 2010 Oct 05; 10(11). PMID: 20890121 Free PMC article.
Malignant messengers. Jocelyn Kaiser. Science, 2016 Apr 29; 352(6282). PMID: 27124448
Zinc phthalocyanines attached to gold nanorods for simultaneous hyperthermic and photodynamic therapies against melanoma in vitro. L F Freitas, M R Hamblin, +4 authors, A M G Plepis. less J Photochem Photobiol B, 2017 Jun 09; 173. PMID: 28595072 Free PMC article.
Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy. Dangge Wang, Tingting Wang, +10 authors, Yaping Li. less Nano Lett, 2016 Aug 16; 16(9). PMID: 27525587
Photodynamic Therapy for Bowen's Disease of the Vulva Area. Hong-Kyu Kang, Jeong-Hwan Yun, +2 authors, Young-Min Son, Joo-Young Roh, Jong-Rok Lee. less Ann Dermatol, 2014 Jun 03; 26(2). PMID: 24882981 Free PMC article.
Ultraviolet B, melanin and mitochondrial DNA: Photo-damage in human epidermal keratinocytes and melanocytes modulated by alpha-melanocyte-stimulating hormone. Markus Böhm, Helene Z Hill. F1000Res, 2016 Jun 16; 5. PMID: 27303631 Free PMC article.
Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53. S C Naumann, W P Roos, +5 authors, B Kaina. less Br J Cancer, 2009 Jan 08; 100(2). PMID: 19127257 Free PMC article.
Treatment of localized prostate cancer using WST-09 and WST-11 mediated vascular targeted photodynamic therapy-A review. A Kawczyk-Krupka, K Wawrzyniec, +3 authors, S K Musiol, M Potempa, A M Bugaj, A Sieroń. less Photodiagnosis Photodyn Ther, 2015 Oct 16; 12(4). PMID: 26467273 Review.
Immune response after photodynamic therapy increases anti-cancer and anti-bacterial effects. Eleonora Reginato, Peter Wolf, Michael R Hamblin. World J Immunol, 2014 Nov 05; 4(1). PMID: 25364655 Free PMC article.
Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells. Daniela Beck, Heike Niessner, +20 authors, Friedegund Meier. less Sci Signal, 2013 Jan 31; 6(260). PMID: 23362240 Free PMC article.
Apoptosis: a review of programmed cell death. Susan Elmore. Toxicol Pathol, 2007 Jun 15; 35(4). PMID: 17562483 Free PMC article. Highly Cited. Review.
Pleiotropic effects of coat colour-associated mutations in humans, mice and other mammals. Monika Reissmann, Arne Ludwig. Semin Cell Dev Biol, 2013 Apr 16; 24(6-7). PMID: 23583561 Review.
ROS-induced autophagy reduces B16F10 melanoma cell proliferative activity. Gustavo Miranda Pires Santos, Susana C P S Oliveira, +5 authors, Antonio L B Pinheiro. less Lasers Med Sci, 2018 Apr 04; 33(6). PMID: 29611065
Intracellularly Generated Immunological Gold Nanoparticles for Combinatorial Photothermal Therapy and Immunotherapy against Tumor. Dan Zhang, Tingting Wu, +5 authors, Zhiping Zhang. less Nano Lett, 2019 Aug 09; 19(9). PMID: 31393134
Plasma-derived Exosomes Reverse Epithelial-to-Mesenchymal Transition after Photodynamic Therapy of Patients with Head and Neck Cancer. Marie-Nicole Theodoraki, Saigopalakrishna S Yerneni, +3 authors, Theresa L Whiteside. less Oncoscience, 2018 Jun 02; 5(3-4). PMID: 29854876 Free PMC article.
Liposomal delivery of ferrous chlorophyllin: A novel third generation photosensitizer for in vitro PDT of melanoma. Iman Gomaa, Aya Sebak, Nagia Afifi, Mahmoud Abdel-Kader. Photodiagnosis Photodyn Ther, 2017 Mar 01; 18. PMID: 28242435
Ocular preservation through limited tumor excision combined with ALA-PDT in patients with periocular basal cell carcinoma. Xinying Li, Liuchang Tan, +4 authors, Yuangang Lu. less Photodiagnosis Photodyn Ther, 2019 Jun 25; 27. PMID: 31233885
Melanoma and autoimmunity: spontaneous regressions as a possible model for new therapeutic approaches. Ion G Motofei. Melanoma Res, 2019 Jan 08; 29(3). PMID: 30615013 Review.
Photodynamic therapy and anti-tumour immunity. Ana P Castano, Pawel Mroz, Michael R Hamblin. Nat Rev Cancer, 2006 Jun 24; 6(7). PMID: 16794636 Free PMC article. Highly Cited. Review.
Enhanced effectiveness of photodynamic therapy with laser light fractionation in patients with esophageal cancer. H Messmann, R M Szeimies, +4 authors, A Holstege. less Endoscopy, 1997 May 01; 29(4). PMID: 9255531
Photodynamic therapy-induced cell surface expression and release of heat shock proteins: relevance for tumor response. Mladen Korbelik, Jinghai Sun, Ivana Cecic. Cancer Res, 2005 Feb 12; 65(3). PMID: 15705903
Primary photodynamic therapy with verteporfin for small pigmented posterior pole choroidal melanoma. I D Fabian, A W Stacey, +5 authors, Medscape. less Eye (Lond), 2017 Mar 25; 31(4). PMID: 28338667 Free PMC article.
Ifenprodil effects on GluN2B-containing glutamate receptors. Stacy A Amico-Ruvio, Meaghan A Paganelli, Jason M Myers, Gabriela K Popescu. Mol Pharmacol, 2012 Sep 01; 82(6). PMID: 22936815 Free PMC article.
State of the science on prevention and screening to reduce melanoma incidence and mortality: The time is now. Mary K Tripp, Meg Watson, +2 authors, Sophie J Balk, Susan M Swetter, Jeffrey E Gershenwald. less CA Cancer J Clin, 2016 May 28; 66(6). PMID: 27232110 Free PMC article. Review.
Stem Cell-Derived Models of Neural Crest Are Essential to Understand Melanoma Progression and Therapy Resistance. Lionel Larribère, Jochen Utikal. Front Mol Neurosci, 2019 May 24; 12. PMID: 31118886 Free PMC article. Review.
Depigmentation in melanomas increases the efficacy of hypericin-mediated photodynamic-induced cell death. Krishna V Sharma, Lester M Davids. Photodiagnosis Photodyn Ther, 2012 May 19; 9(2). PMID: 22594986
5-aminolevulinic acid mediated photodynamic therapy inhibits survival activity and promotes apoptosis of A375 and A431 cells. Jingjing Cai, Qiuping Zheng, Huifang Huang, Buhong Li. Photodiagnosis Photodyn Ther, 2018 Jan 09; 21. PMID: 29309850
Stimulation of dendritic cells by DAMPs in ALA-PDT treated SCC tumor cells. Xiaojie Wang, Jie Ji, +7 authors, Xiuli Wang. less Oncotarget, 2015 Dec 02; 6(42). PMID: 26625309 Free PMC article.
Interstitial photodynamic therapy as salvage treatment for recurrent head and neck cancer. P-J Lou, H R Jäger, +3 authors, L Jones, T Theodossy, S G Bown, C Hopper. less Br J Cancer, 2004 Jul 09; 91(3). PMID: 15238981 Free PMC article.
ALA-PDT promotes HPV-positive cervical cancer cells apoptosis and DCs maturation via miR-34a regulated HMGB1 exosomes secretion. Yichao Jin, Zhen Guan, +4 authors, Ping Cao. less Photodiagnosis Photodyn Ther, 2018 Aug 18; 24. PMID: 30118903
Photodynamic therapy involves an antiangiogenic mechanism and is enhanced by ferrochelatase inhibitor in urothelial carcinoma. Keiji Inoue, Hideo Fukuhara, +6 authors, Taro Shuin. less Cancer Sci, 2013 Mar 14; 104(6). PMID: 23480042 Free PMC article.
5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-Sirt1 axis. Zheng Hu, Haixia Fan, +4 authors, Wenwu Cao. less J Dermatol Sci, 2015 May 20; 79(2). PMID: 25982144
Recent progress in the augmentation of reactive species with nanoplatforms for cancer therapy. Mengqi Wu, Yiming Ding, Linlin Li. Nanoscale, 2019 Oct 16; 11(42). PMID: 31612164 Review.
A randomised, double-blind, placebo-controlled trial of photodynamic therapy using 5-aminolaevulinic acid for the treatment of cervical intraepithelial neoplasia. Adrian A Barnett, J Christoph Haller, +3 authors, David J H Roberts. less Int J Cancer, 2003 Jan 08; 103(6). PMID: 12516106
Metastatic risk and resistance to BRAF inhibitors in melanoma defined by selective allelic loss of ATG5. María García-Fernández, Panagiotis Karras, +8 authors, María S Soengas. less Autophagy, 2016 Jul 28; 12(10). PMID: 27464255 Free PMC article.
The biology of hyperpigmentation syndromes. Reinhart Speeckaert, Mireille Van Gele, +2 authors, Marijn M Speeckaert, Jo Lambert, Nanja van Geel. less Pigment Cell Melanoma Res, 2014 Mar 13; 27(4). PMID: 24612852 Review.
Photodynamic and sonodynamic treatment by phthalocyanine on cancer cell lines. Hana Kolarova, Katerina Tomankova, +2 authors, Robert Bajgar, Petr Kolar, Roman Kubinek. less Ultrasound Med Biol, 2009 Jun 12; 35(8). PMID: 19515482
Carbohydrate-based amphiphilic nano delivery systems for cancer therapy. Kegang Liu, Xiaohua Jiang, Patrick Hunziker. Nanoscale, 2016 Oct 08; 8(36). PMID: 27714108 Review.
Theranostics Based on Iron Oxide and Gold Nanoparticles for Imaging- Guided Photothermal and Photodynamic Therapy of Cancer. S Rajkumar, M Prabaharan. Curr Top Med Chem, 2016 Nov 24; 17(16). PMID: 27875977 Review.
Photodynamic therapy inhibits melanogenesis through paracrine effects by keratinocytes and fibroblasts. Sue Kyung Kim, Seung-Jae Oh, +3 authors, You Chan Kim. less Pigment Cell Melanoma Res, 2017 Oct 19; 31(2). PMID: 29045012
Downregulation of melanogenesis: drug discovery and therapeutic options. Thanigaimalai Pillaiyar, Manoj Manickam, Sang-Hun Jung. Drug Discov Today, 2016 Oct 04; 22(2). PMID: 27693716 Review.
Sonodynamic cancer therapy by a nickel ferrite/carbon nanocomposite on melanoma tumor: In vitro and in vivo studies. M Gorgizadeh, N Azarpira, +3 authors, M Lotfi, F Daneshvar, F Salehi, N Sattarahmady. less Photodiagnosis Photodyn Ther, 2019 May 23; 27. PMID: 31116998
ALA-PDT results in phenotypic changes and decreased cellular invasion in surviving cancer cells. Tsuimin Tsai, Hong Tai Ji, +3 authors, Chin-Tin Chen. less Lasers Surg Med, 2009 Apr 07; 41(4). PMID: 19347942
DC vaccine generated by ALA-PDT-induced immunogenic apoptotic cells for skin squamous cell carcinoma. Jie Ji, Yunfeng Zhang, Wei R Chen, Xiuli Wang. Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471605 Free PMC article.
Morphologic effects of bacteriochlorin a and light in vivo on intraocular melanoma. J J Schuitmaker, G F Vrensen, +3 authors, A de Wolf. less Invest Ophthalmol Vis Sci, 1991 Sep 01; 32(10). PMID: 1894468
Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells. Ming-Feng Wei, Min-Wei Chen, +6 authors, Ming-Jium Shieh. less Autophagy, 2014 Jun 07; 10(7). PMID: 24905352 Free PMC article.
Verteporfin, photofrin II, and merocyanine 540 as PDT photosensitizers against melanoma cells. Patrycja Nowak-Sliwinska, Andrzej Karocki, +3 authors, Krystyna Urbanska. less Biochem Biophys Res Commun, 2006 Sep 02; 349(2). PMID: 16945338
Influence of photodynamic therapy on peripheral immune cell populations and cytokine concentrations in head and neck cancer. M N Theodoraki, K Lorenz, +9 authors, P J Schuler. less Photodiagnosis Photodyn Ther, 2017 Jun 05; 19. PMID: 28578124
Effect of photodynamic therapy on tumor angiogenesis and metastasis in mice bearing Lewis lung carcinoma. I O Lisnjak, V V Kutsenok, +2 authors, L Z Polyschuk, O B Gorobets, N F Gamaleia. less Exp Oncol, 2006 Jan 13; 27(4). PMID: 16404357
In vitro photodynamic activity of 5,15-bis(3-hydroxyphenyl)porphyrin and its halogenated derivatives against cancer cells. Arménio Serra, Marta Pineiro, +4 authors, Maria Filomena Botelho. less Photochem Photobiol, 2009 Nov 13; 86(1). PMID: 19906097
Differentiation-dependent photodynamic therapy regulated by porphobilinogen deaminase in B16 melanoma. D Ickowicz Schwartz, Y Gozlan, +3 authors, Z Malik. less Br J Cancer, 2004 May 20; 90(9). PMID: 15150593 Free PMC article.
Investigating Dynamic Molecular Events in Melanoma Cell Nucleus During Photodynamic Therapy by SERS. Jing Yue, Lijia Liang, +8 authors, Weiqing Xu. less Front Chem, 2019 Feb 13; 6. PMID: 30746359 Free PMC article.
Photodynamic inactivation of viruses using upconversion nanoparticles. Meng Earn Lim, Yen-Ling Lee, Yong Zhang, Justin Jang Hann Chu. Biomaterials, 2011 Dec 14; 33(6). PMID: 22153019
Antivascular treatment of solid melanoma tumors with bacteriochlorophyll-serine-based photodynamic therapy. J Zilberstein, S Schreiber, +6 authors, Y Salomon. less Photochem Photobiol, 2001 Apr 03; 73(3). PMID: 11281022
Understanding the tumor immune microenvironment (TIME) for effective therapy. Mikhail Binnewies, Edward W Roberts, +15 authors, Matthew F Krummel. less Nat Med, 2018 Apr 25; 24(5). PMID: 29686425 Free PMC article. Highly Cited. Review.
A Formulation Study of 5-Aminolevulinic Encapsulated in DPPC Liposomes in Melanoma Treatment. Ming-Wei Lin, Yaw-Bin Huang, +4 authors, Shih-Ya Hung. less Int J Med Sci, 2016 Jul 20; 13(7). PMID: 27429584 Free PMC article.
Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells. C Hao, F Beguinot, +6 authors, K C Petruk. less Cancer Res, 2001 Feb 28; 61(3). PMID: 11221847
Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial: a critical appraisal. L L A Lecluse, Ph I Spuls. Br J Dermatol, 2015 Jan 13; 172(1). PMID: 25581584
Photodynamic therapy as salvage treatment for local failure after chemoradiotherapy in patients with esophageal squamous cell carcinoma: a phase II study. Tomonori Yano, Manabu Muto, +6 authors, Atsushi Ohtsu. less Int J Cancer, 2011 Oct 26; 131(5). PMID: 22024814
The molecular machinery regulating apoptosis signal transduction and its implication in human physiology and pathophysiologies. C T Hellwig, E Passante, M Rehm. Curr Mol Med, 2010 Dec 30; 11(1). PMID: 21189119 Review.
The 5-aminolevulinic acid-induced porphyrin biosynthesis in benign and malignant cells of the skin. K Lang, K Bolsen, +4 authors, C Fritsch. less J Photochem Photobiol B, 2001 Dec 19; 65(1). PMID: 11748002
Primary treatment of choroidal amelanotic melanoma with photodynamic therapy. Mark J Donaldson, Lyndell Lim, +2 authors, C Alex Harper, John Mackenzie, William G Campbell. less Clin Exp Ophthalmol, 2005 Sep 27; 33(5). PMID: 16181294
Inhibition of melanogenesis as an adjuvant strategy in the treatment of melanotic melanomas: selective review and hypothesis. A Slominski, R Paus, M C Mihm. Anticancer Res, 1998 Dec 17; 18(5B). PMID: 9854482 Review.
Glucocorticoid-activated IRE1α/XBP-1s signaling: an autophagy-associated protective pathway against endotheliocyte damage. Yanchun Gao, Hongyi Zhu, +3 authors, Fan Yang, Qiyang Wang, Yong Feng, Changqing Zhang. less Am J Physiol Cell Physiol, 2018 May 17; 315(3). PMID: 29768047
PDT-induced inflammatory and host responses. Małgorzata Firczuk, Dominika Nowis, Jakub Gołąb. Photochem Photobiol Sci, 2011 Jan 25; 10(5). PMID: 21258727
Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response. Angela Ferrario, Natalie Rucker, +2 authors, Sam Wong, Marian Luna, Charles J Gomer. less Cancer Res, 2007 May 19; 67(10). PMID: 17510430
Aloe-emodin-mediated photodynamic therapy induces autophagy and apoptosis in human osteosarcoma cell line MG‑63 through the ROS/JNK signaling pathway. Pinghua Tu, Qiu Huang, +4 authors, Hang Yin. less Oncol Rep, 2016 Apr 02; 35(6). PMID: 27035222 Free PMC article.
Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells. Ancély F Dos Santos, Letícia F Terra, +7 authors, Leticia Labriola. less BMC Cancer, 2017 Mar 17; 17(1). PMID: 28298203 Free PMC article.
Reaction of superoxide anions with melanins: electron spin resonance and spin trapping studies. W Korytowski, B Kalyanaraman, +2 authors, I A Menon, T Sarna, R C Sealy. less Biochim Biophys Acta, 1986 Jun 19; 882(2). PMID: 3011111
BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma. Y Shao, A E Aplin. Cell Death Differ, 2012 Aug 04; 19(12). PMID: 22858545 Free PMC article.
Boosting Tumor-Specific Immunity Using PDT. Nicole Maeding, Thomas Verwanger, Barbara Krammer. Cancers (Basel), 2016 Oct 27; 8(10). PMID: 27782066 Free PMC article. Review.
Autophagy dictates metabolism and differentiation of inflammatory immune cells. Thomas Riffelmacher, Felix Clemens Richter, Anna Katharina Simon. Autophagy, 2017 Aug 15; 14(2). PMID: 28806133 Free PMC article. Review.
Phenothiazine photosensitizers. III. Activity of methylene blue derivatives against pigmented melanoma cell lines. L Rice, M Wainwright, D A Phoemix. J Chemother, 2000 Apr 18; 12(1). PMID: 10768521
Effect of photodynamic therapy on the extracellular matrix and associated components. M d C Pazos, H B Nader. Braz J Med Biol Res, 2007 Aug 01; 40(8). PMID: 17665038 Review.
Application of aluminum chloride phthalocyanine-loaded solid lipid nanoparticles for photodynamic inactivation of melanoma cells. Patrícia L Goto, Marigilson P Siqueira-Moura, Antonio C Tedesco. Int J Pharm, 2017 Jan 09; 518(1-2). PMID: 28063902
Effects of the melanin precursor 5,6-dihydroxy-indole-2-carboxylic acid (DHICA) on DNA damage and repair in the presence of reactive oxygen species. Maria Carolina Pellosi, Andréia Akemi Suzukawa, +5 authors, Glaucia Regina Martinez. less Arch Biochem Biophys, 2014 Jun 04; 557. PMID: 24893147
Involvement of damage-associated molecular patterns in tumor response to photodynamic therapy: surface expression of calreticulin and high-mobility group box-1 release. Mladen Korbelik, Wei Zhang, Soroush Merchant. Cancer Immunol Immunother, 2011 Jun 07; 60(10). PMID: 21644033
Treatment of choroidal melanoma using photodynamic therapy. Irene A Barbazetto, Thomas C Lee, +2 authors, Indira S Rollins, Stanley Chang, David H Abramson. less Am J Ophthalmol, 2003 Jun 06; 135(6). PMID: 12788137
Behavioral Counseling to Prevent Skin Cancer: US Preventive Services Task Force Recommendation Statement. US Preventive Services Task Force, David C Grossman, +14 authors, Chien-Wen Tseng. less JAMA, 2018 Mar 21; 319(11). PMID: 29558558
Marrubium vulgare ethanolic extract induces proliferation block, apoptosis, and cytoprotective autophagy in cancer cells in vitro. V Paunovic, M Kosic, +5 authors, J Harhaji-Trajkovic. less Cell Mol Biol (Noisy-le-grand), 2016 Oct 19; 62(11). PMID: 27755961
Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors. Jean M Mulcahy Levy, Joshua C Thompson, +8 authors, Andrew Thorburn. less Cancer Discov, 2014 May 16; 4(7). PMID: 24823863 Free PMC article. Highly Cited.
Metallo-naphthalocyanines as photothermal sensitisers for experimental tumours: in vitro and in vivo studies. Monica Camerin, Santi Rello-Varona, +2 authors, Giulio Jori. less Lasers Surg Med, 2009 Oct 01; 41(9). PMID: 19790243
Photodynamic Therapy in Melanoma - Where do we Stand? Ioana Baldea, Lorin Giurgiu, +4 authors, Gabriela Adriana Filip. less Curr Med Chem, 2017 Dec 27; 25(40). PMID: 29278205 Review.
A novel pro-apoptotic role of zinc octacarboxyphthalocyanine in melanoma me45 cancer cell's photodynamic therapy (PDT). Joanna Nackiewicz, Marta Kliber-Jasik, Magdalena Skonieczna. J Photochem Photobiol B, 2018 Dec 15; 190. PMID: 30551028
Photodynamic therapy with verteporfin of choroidal malignancy from breast cancer. Vincenzo Isola, Alfredo Pece, Luisa Pierro. Am J Ophthalmol, 2006 Oct 24; 142(5). PMID: 17056382
Photodynamic therapy of murine colon cancer and melanoma using systemic aminolevulinic acid as a photosensitizer. R Haddad, O Kaplan, +3 authors, R Greenberg, A Siegal, Y Skornick, H Kashtan. less Int J Surg Investig, 2003 Apr 08; 2(3). PMID: 12678516
Autophagy in Cancer: Regulation by Small Molecules. Allison S Limpert, Lester J Lambert, +4 authors, Nicholas D P Cosford. less Trends Pharmacol Sci, 2018 Nov 21; 39(12). PMID: 30454769 Free PMC article. Review.
Photodynamic ablation of early cancers of the stomach by means of mTHPC and laser irradiation: preliminary clinical experience. C Ell, L Gossner, +4 authors, R Sroka. less Gut, 1998 Dec 24; 43(3). PMID: 9863479 Free PMC article.
Apoptosis induced by methylene-blue-mediated photodynamic therapy in melanomas and the involvement of mitochondrial dysfunction revealed by proteomics. Yongjun Chen, Wei Zheng, +3 authors, Pingping Shen. less Cancer Sci, 2008 Nov 20; 99(10). PMID: 19016762
Necroptosis: Mechanisms and Relevance to Disease. Lorenzo Galluzzi, Oliver Kepp, Francis Ka-Ming Chan, Guido Kroemer. Annu Rev Pathol, 2016 Dec 14; 12. PMID: 27959630 Free PMC article. Highly Cited. Review.
Photosensitizer coated upconversion nanoparticles for triggering reactive oxygen species under 980 nm near-infrared excitation. Jinhua Wu, Shanshan Du, Yuhua Wang. J Mater Chem B, 2019 Nov 02; 7(46). PMID: 31670352
Real-time vascular imaging and photodynamic therapy efficacy with micelle-nanocarrier delivery of chlorin e6 to the microenvironment of melanoma. Chien-Hsing Lee, Ping-Shan Lai, +11 authors, Din-Ping Tsai. less J Dermatol Sci, 2015 Sep 12; 80(2). PMID: 26360010
Update on melanoma epigenetics. Blanca de Unamuno, Sarai Palanca, Rafael Botella. Curr Opin Oncol, 2015 Jul 22; 27(5). PMID: 26197354 Review.
Dinitrophenyl hapten with laser immunotherapy for advanced malignant melanoma: A clinical study. Dian-Jun Chen, Xiao-Song Li, +8 authors, Wei-R Chen. less Oncol Lett, 2017 Apr 30; 13(3). PMID: 28454272 Free PMC article.
Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy. Frédéric Schmitt, Padavattan Govindaswamy, +3 authors, Bruno Therrien. less J Biol Inorg Chem, 2008 Sep 24; 14(1). PMID: 18810507
Upconversion nanoparticles for photodynamic therapy and other cancer therapeutics. Chao Wang, Liang Cheng, Zhuang Liu. Theranostics, 2013 May 08; 3(5). PMID: 23650479 Free PMC article. Review.
Photodynamic therapy in melanoma--an update. I Baldea, A G Filip. J Physiol Pharmacol, 2012 Jun 02; 63(2). PMID: 22653896 Review.
Photodynamic therapy with chlorin e(6) for skin metastases of melanoma. Sergey V Sheleg, Edvard A Zhavrid, +4 authors, Ivan N Zhuravkin. less Photodermatol Photoimmunol Photomed, 2004 Jan 24; 20(1). PMID: 14738529
Photodynamic therapy-induced killing is enhanced in depigmented metastatic melanoma cells. Krishna V Sharma, Natalie Bowers, Lester M Davids. Cell Biol Int, 2011 May 06; 35(9). PMID: 21542806
Photodynamic activities of silicon phthalocyanines against achromic M6 melanoma cells and healthy human melanocytes and keratinocytes. R Decreau, M J Richard, +2 authors, P Verrando, M Chanon, M Julliard. less J Photochem Photobiol B, 1999 Apr 17; 48(1). PMID: 10205878
Melanocyte function and its control by melanocortin peptides. Marina Tsatmali, Janis Ancans, Anthony J Thody. J Histochem Cytochem, 2002 Jan 19; 50(2). PMID: 11799132 Review.
St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death. Britta Kleemann, Benjamin Loos, +2 authors, Thomas J Scriba, Dirk Lang, Lester M Davids. less PLoS One, 2014 Jul 31; 9(7). PMID: 25076130 Free PMC article.
Engineering pharmaceutical nanocarriers for photodynamic therapy on wound healing: Review. Karuppusamy Shanmugapriya, Hyun Wook Kang. Mater Sci Eng C Mater Biol Appl, 2019 Sep 25; 105. PMID: 31546465 Review.
Methylene blue photodynamic therapy in malignant melanoma decreases expression of proliferating cell nuclear antigen and heparanases. M Wagner, E R Suarez, +5 authors, M A S Pinhal. less Clin Exp Dermatol, 2012 Feb 04; 37(5). PMID: 22299594
Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy. Lester M Davids, Britta Kleemann, Susan Cooper, Susan H Kidson. Cell Biol Int, 2009 Jul 15; 33(10). PMID: 19596456
Cutaneous photoprotection and melanoma susceptibility: reaching beyond melanin content to the frontiers of DNA repair. Ana Luisa Kadekaro, Kazumasa Wakamatsu, Shosuke Ito, Zalfa A Abdel-Malek. Front Biosci, 2006 May 25; 11. PMID: 16720302 Review.
Factors affecting aminolaevulinic acid-induced generation of protoporphyrin IX. L Wyld, J L Burn, M W Reed, N J Brown. Br J Cancer, 1997 Jan 01; 76(6). PMID: 9310234 Free PMC article.
T-cell mediated anti-tumor immunity after photodynamic therapy: why does it not always work and how can we improve it? Florian Anzengruber, Pinar Avci, Lucas Freitas de Freitas, Michael R Hamblin. Photochem Photobiol Sci, 2015 Jun 13; 14(8). PMID: 26062987 Free PMC article.
Apoptosis in the pathogenesis and treatment of disease. C B Thompson. Science, 1995 Mar 10; 267(5203). PMID: 7878464 Highly Cited. Review.
Monitoring photodynamic therapy of solid tumors online by BOLD-contrast MRI. Shimon Gross, Assaf Gilead, +2 authors, Avigdor Scherz, Michal Neeman, Yoram Salomon. less Nat Med, 2003 Sep 23; 9(10). PMID: 14502284
AUSTRALIAN AND NEW ZEALAND STUDY OF PHOTODYNAMIC THERAPY IN CHOROIDAL AMELANOTIC MELANOMA. Roderick F O'Day, Tanya M Pejnovic, +3 authors, William G Campbell. less Retina, 2019 Mar 26; 40(5). PMID: 30908472
Microneedle-Assisted Topical Delivery of Photodynamically Active Mesoporous Formulation for Combination Therapy of Deep-Seated Melanoma. Huijun Phoebe Tham, Keming Xu, +6 authors, Yanli Zhao. less ACS Nano, 2018 Nov 18; 12(12). PMID: 30444343
Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas. Krystyna Urbanska, Bozena Romanowska-Dixon, +3 authors, Grazyna Stochel. less Acta Biochim Pol, 2002 Oct 05; 49(2). PMID: 12362980
On the in vivo photochemical rate parameters for PDT reactive oxygen species modeling. Michele M Kim, Ashwini A Ghogare, Alexander Greer, Timothy C Zhu. Phys Med Biol, 2017 Feb 07; 62(5). PMID: 28166056 Free PMC article. Review.
Combination effect of photodynamic and sonodynamic therapy on experimental skin squamous cell carcinoma in C3H/HeN mice. Z H Jin, N Miyoshi, +11 authors, M Kumakiri. less J Dermatol, 2000 Jun 30; 27(5). PMID: 10875195
Increased melanogenesis is a risk factor for oxidative DNA damage--study on cultured melanocytes and atypical nevus cells. Nico P M Smit, Frans A van Nieuwpoort, +5 authors, Stan Pavel. less Photochem Photobiol, 2008 Apr 26; 84(3). PMID: 18435613
Targeting metastasis-initiating cells through the fatty acid receptor CD36. Gloria Pascual, Alexandra Avgustinova, +10 authors, Salvador Aznar Benitah. less Nature, 2016 Dec 16; 541(7635). PMID: 27974793 Highly Cited.
Exosomes and tumor-mediated immune suppression. Theresa L Whiteside. J Clin Invest, 2016 Mar 02; 126(4). PMID: 26927673 Free PMC article. Highly Cited. Review.
The regulation of epidermal melanogenesis via cAMP and/or PKC signaling pathways: insights for the development of hypopigmenting agents. Ai-Young Lee, Minsoo Noh. Arch Pharm Res, 2013 Apr 23; 36(7). PMID: 23604723 Review.
Photodynamic properties of ZnTPPS(4), ClAlPcS(2) and ALA in human melanoma G361 cells. E Krestyn, H Kolarova, R Bajgar, K Tomankova. Toxicol In Vitro, 2009 Sep 02; 24(1). PMID: 19720133
Photocatalytic and Cytotoxic Effects of Nitrogen-Doped TiO₂ Nanoparticles on Melanoma Cells. Pedro Faria Zeni, Disley Prates Dos Santos, +5 authors, Maria Lucila Hernández-Macedo. less J Nanosci Nanotechnol, 2018 Feb 15; 18(5). PMID: 29442890
Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells. Denis Selimovic, Benjamin B O W Porzig, +6 authors, Mohamed Hassan. less Cell Signal, 2012 Oct 20; 25(1). PMID: 23079083
A new method for photodynamic therapy of melanotic melanoma -- effects of depigmentation with violet light photodynamic therapy. Li-Wei Ma, Kristian Pagh Nielsen, Vladimir Iani, Johan Moan. J Environ Pathol Toxicol Oncol, 2008 Jan 17; 26(3). PMID: 18197832
Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma. Xiaoqi Xie, Ju Yong Koh, +2 authors, Sandy Price, Eileen White, Janice M Mehnert. less Cancer Discov, 2015 Feb 13; 5(4). PMID: 25673642 Free PMC article. Highly Cited.
Pro-tolerogenic effects of photodynamic therapy with TH9402 on dendritic cells. Raewyn Broady, Jie Yu, Megan K Levings. J Clin Apher, 2008 Apr 03; 23(2). PMID: 18381757
Susceptibility of In Vitro Melanoma Skin Cancer to Photoactivated Hypericin versus Aluminium(III) Phthalocyanine Chloride Tetrasulphonate. I M Ndhundhuma, H Abrahamse. Biomed Res Int, 2017 Nov 18; 2017. PMID: 29147654 Free PMC article.
Robust Photodynamic Therapy Using 5-ALA-Incorporated Nanocomplexes Cures Metastatic Melanoma through Priming of CD4+CD8+ Double Positive T Cells. Zhi Li, Cuifeng Wang, +6 authors, Min Feng. less Adv Sci (Weinh), 2019 Mar 20; 6(5). PMID: 30886812 Free PMC article.
Platinum(II) Ring-Fused Chlorins as Near-Infrared Emitting Oxygen Sensors and Photodynamic Agents. Nelson A M Pereira, Mafalda Laranjo, +9 authors, Teresa M V D Pinho E Melo. less ACS Med Chem Lett, 2017 Mar 25; 8(3). PMID: 28337322 Free PMC article.
Systemic antitumor effect of intratumoral injection of dendritic cells in combination with local photodynamic therapy. Hisashi Saji, Wenru Song, +2 authors, Katsuyoshi Furumoto, Harubumi Kato, Edgar G Engleman. less Clin Cancer Res, 2006 Apr 28; 12(8). PMID: 16638867
miR-7112-3p targets PERK to regulate the endoplasmic reticulum stress pathway and apoptosis induced by photodynamic therapy in colorectal cancer CX-1 cells. Fanhua Kong, Heng Zou, +4 authors, Xiongying Miao. less Photodiagnosis Photodyn Ther, 2020 Jan 17; 29. PMID: 31945549
Redox- and light-responsive alginate nanoparticles as effective drug carriers for combinational anticancer therapy. Chuangnian Zhang, Gaona Shi, +7 authors, Deling Kong. less Nanoscale, 2017 Feb 23; 9(9). PMID: 28225139
Gold mining for PDT: Great expectations from tiny nanoparticles. Nikolai F Gamaleia, Irina O Shton. Photodiagnosis Photodyn Ther, 2015 Mar 31; 12(2). PMID: 25818545 Review.
Autophagy is a protective mechanism for human melanoma cells under acidic stress. Maria Lucia Marino, Paola Pellegrini, +8 authors, Angelo De Milito. less J Biol Chem, 2012 Jul 05; 287(36). PMID: 22761435 Free PMC article.
Chloride intracellular channel 4 involves in the reduced invasiveness of cancer cells treated by photodynamic therapy. Pei-Chi Chiang, Ruey-Hwang Chou, +2 authors, Hsiung-Fei Chien, Tsuimin Tsai, Chin-Tin Chen. less Lasers Surg Med, 2013 Jan 17; 45(1). PMID: 23322262
Effects of Photodynamic Therapy with Redaporfin on Tumor Oxygenation and Blood Flow in a Lung Cancer Mouse Model. Malwina Karwicka, Barbara Pucelik, +2 authors, Michał Gonet, Martyna Elas, Janusz M Dąbrowski. less Sci Rep, 2019 Sep 04; 9(1). PMID: 31477749 Free PMC article.
The present and future role of photodynamic therapy in cancer treatment. Stanley B Brown, Elizabeth A Brown, Ian Walker. Lancet Oncol, 2004 Aug 04; 5(8). PMID: 15288239 Highly Cited. Review.
CK1α, CK1δ, and CK1ε are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis. Sarah Hanna-Addams, Shuzhen Liu, +2 authors, Hua Liu, She Chen, Zhigao Wang. less Proc Natl Acad Sci U S A, 2020 Jan 15; 117(4). PMID: 31932442 Free PMC article.
Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma. Victoria Monge-Fuentes, Luis Alexandre Muehlmann, Ricardo Bentes de Azevedo. Nano Rev, 2014 Oct 16; 5. PMID: 25317253 Free PMC article. Review.
Cutaneous malignant melanoma: ESMO clinical recommendations for diagnosis, treatment and follow-up. R Dummer, A Hauschild, G Pentheroudakis. Ann Oncol, 2009 Jul 10; 20 Suppl 4. PMID: 19454433 Review.
A combination of photodynamic therapy and chemotherapy displays a differential cytotoxic effect on human metastatic melanoma cells. Fa Nsole Biteghe, L M Davids. J Photochem Photobiol B, 2016 Nov 17; 166. PMID: 27852006
Programming DNA Nanoassembly for Enhanced Photodynamic Therapy. Min Pan, Qunying Jiang, +4 authors, Xiaoqing Liu. less Angew Chem Int Ed Engl, 2019 Nov 07; 59(5). PMID: 31696593
Direct tumor damage mechanisms of photodynamic therapy. Dominika Nowis, Marcin Makowski, +3 authors, Jakub Gołab. less Acta Biochim Pol, 2005 Jul 02; 52(2). PMID: 15990919 Review.
Targeting Programmed Cell Death -1 (PD-1) and Ligand (PD-L1): A new era in cancer active immunotherapy. Anastasia Constantinidou, Constantinos Alifieris, Dimitrios T Trafalis. Pharmacol Ther, 2018 Oct 01; 194. PMID: 30268773 Highly Cited. Review.
Reduced MiR-675 in exosome in H19 RNA-related melanogenesis via MITF as a direct target. Nan-Hyung Kim, Soo-Hyun Choi, +3 authors, Ai-Young Lee. less J Invest Dermatol, 2013 Dec 18; 134(4). PMID: 24335901
Ultrasound activation of TiO2 in melanoma tumors. Yoshimi Harada, Koichi Ogawa, +4 authors, Katsuro Tachibana. less J Control Release, 2010 Oct 19; 149(2). PMID: 20951750
Nanoparticles improve biological functions of phthalocyanine photosensitizers used for photodynamic therapy. Xiao Jia, Lee Jia. Curr Drug Metab, 2012 Mar 03; 13(8). PMID: 22380016 Review.
Inhibition of heme oxygenase-1 increases responsiveness of melanoma cells to ALA-based photodynamic therapy. Jürgen Frank, Mohammad Reza Lornejad-Schäfer, +3 authors, Hans K Biesalski. less Int J Oncol, 2007 Nov 06; 31(6). PMID: 17982681
Screening for Skin Cancer: US Preventive Services Task Force Recommendation Statement. US Preventive Services Task Force, Kirsten Bibbins-Domingo, +15 authors, Albert L Siu. less JAMA, 2016 Jul 28; 316(4). PMID: 27458948 Highly Cited.
Efficacy of topical ALA-PDT combined with excision in the treatment of skin malignant tumor. Yuan-gang Lu, Yuan-yuan Wang, +5 authors, Guo-ling Li. less Photodiagnosis Photodyn Ther, 2014 Feb 27; 11(2). PMID: 24568889
Precise control of apoptosis via gold nanostars for dose dependent photothermal therapy of melanoma. Peng Xu, Peng Ning, +3 authors, Jingjing Wang, Yao Qin, Feng Liang, Yu Cheng. less J Mater Chem B, 2019 Nov 02; 7(44). PMID: 31675048
Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity. Malgorzata Wachowska, Angelika Muchowicz, Jakub Golab. Front Oncol, 2015 Aug 19; 5. PMID: 26284197 Free PMC article. Review.
Proteomic Analysis of Resistance of Gram-Negative Bacteria to Chlorhexidine and Impacts on Susceptibility to Colistin, Antimicrobial Peptides, and Ceragenins. Marjan M Hashemi, Brett S Holden, +10 authors, Paul B Savage. less Front Microbiol, 2019 Mar 06; 10. PMID: 30833936 Free PMC article.
Apoptosis: controlled demolition at the cellular level. Rebecca C Taylor, Sean P Cullen, Seamus J Martin. Nat Rev Mol Cell Biol, 2007 Dec 13; 9(3). PMID: 18073771 Highly Cited. Review.
Molecular Pathways: The Necrosome-A Target for Cancer Therapy. Lena Seifert, George Miller. Clin Cancer Res, 2016 Dec 10; 23(5). PMID: 27932417 Free PMC article. Review.
The "nano to micro" transition of hydrophobic curcumin crystals leading to in situ adjuvant depots for Au-liposome nanoparticle mediated enhanced photothermal therapy. Syed Baseeruddin Alvi, Tejaswini Appidi, +8 authors, Aravind Kumar Rengan. less Biomater Sci, 2019 Jul 17; 7(9). PMID: 31309204
A tissue factor-cascade-targeted strategy to tumor vasculature: a combination of EGFP-EGF1 conjugation nanoparticles with photodynamic therapy. Wei Shi, Yanxue Yin, +9 authors, Yu Hu. less Oncotarget, 2016 Oct 30; 8(19). PMID: 27793028 Free PMC article.
Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells. S Martin, A M Dudek-Perić, +5 authors, P Agostinis. less Biochem Pharmacol, 2014 Dec 23; 93(3). PMID: 25529535
Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells. Lester M Davids, Britta Kleemann, +2 authors, Denisa Kacerovská, Karl Pizinger, Susan H Kidson. less J Photochem Photobiol B, 2008 Mar 18; 91(2-3). PMID: 18342534
Photodynamic therapy for lung cancer and malignant pleural mesothelioma. Charles B Simone, Keith A Cengel. Semin Oncol, 2014 Dec 17; 41(6). PMID: 25499640 Free PMC article. Review.
The effect of a bicarbonate-phosphate combination, without and with fluoride, on the growth and dental caries in the rat. H Luoma, L Turtola, +2 authors, Y Collan, J Meurman, S Helminen. less Caries Res, 1972 Jan 01; 6(2). PMID: 4502284
Lesion oxygenation associates with clinical outcomes in premalignant and early stage head and neck tumors treated on a phase 1 trial of photodynamic therapy. Peter H Ahn, Jarod C Finlay, +16 authors, Theresa M Busch. less Photodiagnosis Photodyn Ther, 2017 Nov 09; 21. PMID: 29113960 Free PMC article.
Crosslinked self-assembled nanoparticles for chemo-sonodynamic combination therapy favoring antitumor, antimetastasis management and immune responses. Mengrui Liu, Abdur Rauf Khan, +3 authors, Jianbo Ji, Guimei Lin, Xiaogang Zhao, Guangxi Zhai. less J Control Release, 2018 Oct 12; 290. PMID: 30308258
In vitro efficiency and mechanistic role of indocyanine green as photodynamic therapy agent for human melanoma. Abdel-Megid Mamoon, Amira M Gamal-Eldeen, +3 authors, Lisa M Miller. less Photodiagnosis Photodyn Ther, 2009 Aug 18; 6(2). PMID: 19683211

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