. 2020 Jun; 10:597.
doi: 10.3389/fonc.2020.00597.

Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma

Xin-Ying Li 1 Liu-Chang Tan 1 Li-Wen Dong 1 Wan-Qi Zhang 1 Xiao-Xiao Shen 1 Xiao Lu 2 Hong Zheng 2 Yuan-Gang Lu 1 
  • PMID: 32528867
  •     199 References
  •     7 citations


Melanoma is the most aggressive malignant skin tumor and arises from melanocytes. The resistance of melanoma cells to various treatments results in rapid tumor growth and high mortality. As a local therapeutic modality, photodynamic therapy has been successfully applied for clinical treatment of skin diseases. Photodynamic therapy is a relatively new treatment method for various types of malignant tumors in humans and, compared to conventional treatment methods, has fewer side effects, and is more accurate and non-invasive. Although several in vivo and in vitro studies have shown encouraging results regarding the potential benefits of photodynamic therapy as an adjuvant treatment for melanoma, its clinical application remains limited owing to its relative inefficiency. This review article discusses the use of photodynamic therapy in melanoma treatment as well as the latest progress made in deciphering the mechanism of tolerance. Lastly, potential targets are identified that may improve photodynamic therapy against melanoma cells.

Keywords: apoptosis; autophagy; melanoma; photodynamic therapy; tumor immunity.

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Curr Med Chem, 2017 Dec 27; 25(40). PMID: 29278205
A novel pro-apoptotic role of zinc octacarboxyphthalocyanine in melanoma me45 cancer cell's photodynamic therapy (PDT).
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J Photochem Photobiol B, 2018 Dec 15; 190. PMID: 30551028
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Nat Med, 2003 Sep 23; 9(10). PMID: 14502284
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Robust Photodynamic Therapy Using 5-ALA-Incorporated Nanocomplexes Cures Metastatic Melanoma through Priming of CD4+CD8+ Double Positive T Cells.
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miR-7112-3p targets PERK to regulate the endoplasmic reticulum stress pathway and apoptosis induced by photodynamic therapy in colorectal cancer CX-1 cells.
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Chloride intracellular channel 4 involves in the reduced invasiveness of cancer cells treated by photodynamic therapy.
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Programming DNA Nanoassembly for Enhanced Photodynamic Therapy.
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Molecular Pathways: The Necrosome-A Target for Cancer Therapy.
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