Review
. 2020 Jul; 17(8):807-821.
doi: 10.1038/s41423-020-0488-6.

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

Yuanyuan Zhang 1 Zemin Zhang 2 
Affiliations
  • PMID: 32612154
  •     237 References
  •     125 citations

Abstract

Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and immune checkpoint inhibitors (ICIs), have obtained durable clinical responses, but their efficacies vary, and only subsets of cancer patients can benefit from them. Immune infiltrates in the tumor microenvironment (TME) have been shown to play a key role in tumor development and will affect the clinical outcomes of cancer patients. Comprehensive profiling of tumor-infiltrating immune cells would shed light on the mechanisms of cancer-immune evasion, thus providing opportunities for the development of novel therapeutic strategies. However, the highly heterogeneous and dynamic nature of the TME impedes the precise dissection of intratumoral immune cells. With recent advances in single-cell technologies such as single-cell RNA sequencing (scRNA-seq) and mass cytometry, systematic interrogation of the TME is feasible and will provide insights into the functional diversities of tumor-infiltrating immune cells. In this review, we outline the recent progress in cancer immunotherapy, particularly by focusing on landmark studies and the recent single-cell characterization of tumor-associated immune cells, and we summarize the phenotypic diversities of intratumoral immune cells and their connections with cancer immunotherapy. We believe such a review could strengthen our understanding of the progress in cancer immunotherapy, facilitate the elucidation of immune cell modulation in tumor progression, and thus guide the development of novel immunotherapies for cancer treatment.

Keywords: Immunotherapy; Phenotypic diversities; Single-cell technologies; Tumor microenvironment; Tumor-infiltrating immune cells.

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Cell Res, 2016 Dec 21; 27(1). PMID: 27995907    Free PMC article.
Highly Cited. Review.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
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Spencer C Wei, Jacob H Levine, +8 authors, James P Allison.
Cell, 2017 Aug 15; 170(6). PMID: 28803728    Free PMC article.
Highly Cited.
The generation of antibody-secreting plasma cells.
Stephen L Nutt, Philip D Hodgkin, David M Tarlinton, Lynn M Corcoran.
Nat Rev Immunol, 2015 Feb 24; 15(3). PMID: 25698678
Highly Cited. Review.
Somatic generation of antibody diversity.
S Tonegawa.
Nature, 1983 Apr 14; 302(5909). PMID: 6300689
Highly Cited. Review.
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Alexander D Gitlin, Ziv Shulman, Michel C Nussenzweig.
Nature, 2014 May 09; 509(7502). PMID: 24805232    Free PMC article.
Highly Cited.
Effector and regulatory B cells: modulators of CD4+ T cell immunity.
Frances E Lund, Troy D Randall.
Nat Rev Immunol, 2010 Mar 13; 10(4). PMID: 20224569    Free PMC article.
Highly Cited. Review.
B cells and tertiary lymphoid structures promote immunotherapy response.
Beth A Helmink, Sangeetha M Reddy, +57 authors, Jennifer A Wargo.
Nature, 2020 Jan 17; 577(7791). PMID: 31942075    Free PMC article.
Highly Cited.
Tertiary lymphoid structures in the era of cancer immunotherapy.
Catherine Sautès-Fridman, Florent Petitprez, Julien Calderaro, Wolf Herman Fridman.
Nat Rev Cancer, 2019 May 17; 19(6). PMID: 31092904
Highly Cited. Review.
B cell regulation in cancer and anti-tumor immunity.
Anushruti Sarvaria, J Alejandro Madrigal, Aurore Saudemont.
Cell Mol Immunol, 2017 Jun 20; 14(8). PMID: 28626234    Free PMC article.
Highly Cited. Review.
B cells inhibit induction of T cell-dependent tumor immunity.
Z Qin, G Richter, +3 authors, T Blankenstein.
Nat Med, 1998 May 19; 4(5). PMID: 9585241
Highly Cited.
FcRgamma activation regulates inflammation-associated squamous carcinogenesis.
Pauline Andreu, Magnus Johansson, +11 authors, Lisa M Coussens.
Cancer Cell, 2010 Feb 09; 17(2). PMID: 20138013    Free PMC article.
Highly Cited.
B-cell-derived lymphotoxin promotes castration-resistant prostate cancer.
Massimo Ammirante, Jun-Li Luo, +2 authors, Michael Karin.
Nature, 2010 Mar 12; 464(7286). PMID: 20220849    Free PMC article.
Highly Cited.
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Khalid I Al-Shibli, Tom Donnem, +3 authors, Lill-Tove Busund.
Clin Cancer Res, 2008 Aug 14; 14(16). PMID: 18698040
Highly Cited.
CD20+ tumor-infiltrating lymphocytes have an atypical CD27- memory phenotype and together with CD8+ T cells promote favorable prognosis in ovarian cancer.
Julie S Nielsen, Rob A Sahota, +4 authors, Brad H Nelson.
Clin Cancer Res, 2012 May 04; 18(12). PMID: 22553348
Highly Cited.
Tertiary lymphoid structures improve immunotherapy and survival in melanoma.
Rita Cabrita, Martin Lauss, +22 authors, Göran Jönsson.
Nature, 2020 Jan 17; 577(7791). PMID: 31942071
Highly Cited.
B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation.
Bernd Jahrsdörfer, Sue E Blackwell, +5 authors, George J Weiner.
Blood, 2006 Jul 01; 108(8). PMID: 16809616    Free PMC article.
Innate or adaptive immunity? The example of natural killer cells.
Eric Vivier, David H Raulet, +5 authors, Sophie Ugolini.
Science, 2011 Jan 08; 331(6013). PMID: 21212348    Free PMC article.
Highly Cited. Review.
Adaptive immune features of natural killer cells.
Joseph C Sun, Joshua N Beilke, Lewis L Lanier.
Nature, 2009 Jan 13; 457(7229). PMID: 19136945    Free PMC article.
Highly Cited.
The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy.
Sourav Paul, Girdhari Lal.
Front Immunol, 2017 Sep 29; 8. PMID: 28955340    Free PMC article.
Highly Cited. Review.
NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control.
Jan P Böttcher, Eduardo Bonavita, +7 authors, Caetano Reis e Sousa.
Cell, 2018 Feb 13; 172(5). PMID: 29429633    Free PMC article.
Highly Cited.
Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants.
Loredana Ruggeri, Marusca Capanni, +9 authors, Andrea Velardi.
Science, 2002 Mar 16; 295(5562). PMID: 11896281
Highly Cited.
A chimeric receptor with NKG2D specificity enhances natural killer cell activation and killing of tumor cells.
Yu-Hsiang Chang, John Connolly, +3 authors, Dario Campana.
Cancer Res, 2013 Jan 11; 73(6). PMID: 23302231
Highly Cited.
IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion.
Kevin C Conlon, E Lake Potter, +15 authors, Thomas A Waldmann.
Clin Cancer Res, 2019 May 31; 25(16). PMID: 31142503    Free PMC article.
Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity.
Lucas Ferrari de Andrade, Rong En Tay, +14 authors, Kai W Wucherpfennig.
Science, 2018 Mar 31; 359(6383). PMID: 29599246    Free PMC article.
Highly Cited.
Antibody-dependent cell cytotoxicity: immunotherapy strategies enhancing effector NK cells.
Maria Carmen Ochoa, Luna Minute, +5 authors, Pedro Berraondo.
Immunol Cell Biol, 2017 Feb 01; 95(4). PMID: 28138156
Highly Cited. Review.
Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies.
Holbrook E Kohrt, Ariane Thielens, +14 authors, Pascale André.
Blood, 2013 Dec 12; 123(5). PMID: 24326534    Free PMC article.
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Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells.
Takahiro Kamiya, See Voon Seow, +2 authors, Dario Campana.
J Clin Invest, 2019 Mar 13; 129(5). PMID: 30860984    Free PMC article.
Highly Cited.
Development of monocytes, macrophages, and dendritic cells.
Frederic Geissmann, Markus G Manz, +3 authors, Klaus Ley.
Science, 2010 Feb 06; 327(5966). PMID: 20133564    Free PMC article.
Highly Cited. Review.
The role of myeloid cells in cancer therapies.
Camilla Engblom, Christina Pfirschke, Mikael J Pittet.
Nat Rev Cancer, 2016 Jun 25; 16(7). PMID: 27339708
Highly Cited. Review.
Myeloid lineage commitment from the hematopoietic stem cell.
Hiromi Iwasaki, Koichi Akashi.
Immunity, 2007 Jun 22; 26(6). PMID: 17582345
Highly Cited. Review.
Neutrophils in cancer: neutral no more.
Seth B Coffelt, Max D Wellenstein, Karin E de Visser.
Nat Rev Cancer, 2016 Jun 11; 16(7). PMID: 27282249
Highly Cited. Review.
Neutrophils escort circulating tumour cells to enable cell cycle progression.
Barbara Maria Szczerba, Francesc Castro-Giner, +14 authors, Nicola Aceto.
Nature, 2019 Feb 08; 566(7745). PMID: 30728496
Highly Cited.
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Andrea Ponzetta, Roberta Carriero, +20 authors, Sebastien Jaillon.
Cell, 2019 Jul 02; 178(2). PMID: 31257026    Free PMC article.
Highly Cited.
Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN.
Zvi G Fridlender, Jing Sun, +5 authors, Steven M Albelda.
Cancer Cell, 2009 Sep 08; 16(3). PMID: 19732719    Free PMC article.
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Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo.
Shalin H Naik, Priyanka Sathe, +10 authors, Ken Shortman.
Nat Immunol, 2007 Oct 09; 8(11). PMID: 17922015
Highly Cited.
The nature of the principal type 1 interferon-producing cells in human blood.
F P Siegal, N Kadowaki, +5 authors, Y J Liu.
Science, 1999 Jun 12; 284(5421). PMID: 10364556
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Plasmacytoid dendritic cell in immunity and cancer.
Dana Mitchell, Sreenivasulu Chintala, Mahua Dey.
J Neuroimmunol, 2018 Jul 28; 322. PMID: 30049538
Review.
Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6.
Gaetan Jego, A Karolina Palucka, +3 authors, Jacques Banchereau.
Immunity, 2003 Aug 23; 19(2). PMID: 12932356
Highly Cited.
Type I Interferon in Chronic Virus Infection and Cancer.
Laura M Snell, Tracy L McGaha, David G Brooks.
Trends Immunol, 2017 Jun 06; 38(8). PMID: 28579323    Free PMC article.
Highly Cited. Review.
Immune escape mechanisms as a guide for cancer immunotherapy.
Gregory L Beatty, Whitney L Gladney.
Clin Cancer Res, 2014 Dec 17; 21(4). PMID: 25501578    Free PMC article.
Highly Cited. Review.
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species.
Martin Guilliams, Charles-Antoine Dutertre, +29 authors, Florent Ginhoux.
Immunity, 2016 Sep 18; 45(3). PMID: 27637149    Free PMC article.
Highly Cited.
Development and function of dendritic cell subsets.
Alexander Mildner, Steffen Jung.
Immunity, 2014 May 20; 40(5). PMID: 24837101
Highly Cited. Review.
Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.
Stefani Spranger, Daisy Dai, Brendan Horton, Thomas F Gajewski.
Cancer Cell, 2017 May 10; 31(5). PMID: 28486109    Free PMC article.
Highly Cited.
Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma.
Edward W Roberts, Miranda L Broz, +7 authors, Matthew F Krummel.
Cancer Cell, 2016 Jul 19; 30(2). PMID: 27424807    Free PMC article.
Highly Cited.
Human dendritic cell subsets: an update.
Matthew Collin, Venetia Bigley.
Immunology, 2018 Jan 10; 154(1). PMID: 29313948    Free PMC article.
Highly Cited. Review.
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.
Chrysothemis C Brown, Herman Gudjonson, +9 authors, Alexander Y Rudensky.
Cell, 2019 Nov 02; 179(4). PMID: 31668803    Free PMC article.
Highly Cited.
High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization.
Marcela Alcántara-Hernández, Rebecca Leylek, +6 authors, Juliana Idoyaga.
Immunity, 2017 Dec 10; 47(6). PMID: 29221729    Free PMC article.
Highly Cited.
Harnessing the antitumor potential of macrophages for cancer immunotherapy.
Kristen B Long, Gregory L Beatty.
Oncoimmunology, 2014 Feb 06; 2(12). PMID: 24498559    Free PMC article.
Review.
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion.
Rose Du, Kan V Lu, +8 authors, Gabriele Bergers.
Cancer Cell, 2008 Mar 11; 13(3). PMID: 18328425    Free PMC article.
Highly Cited.
Protective and pathogenic functions of macrophage subsets.
Peter J Murray, Thomas A Wynn.
Nat Rev Immunol, 2011 Oct 15; 11(11). PMID: 21997792    Free PMC article.
Highly Cited. Review.
Metalloproteinases and their natural inhibitors in inflammation and immunity.
Rama Khokha, Aditya Murthy, Ashley Weiss.
Nat Rev Immunol, 2013 Aug 24; 13(9). PMID: 23969736
Highly Cited. Review.
Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses.
Yonit Lavin, Soma Kobayashi, +26 authors, Miriam Merad.
Cell, 2017 May 06; 169(4). PMID: 28475900    Free PMC article.
Highly Cited.
Lineage tracking reveals dynamic relationships of T cells in colorectal cancer.
Lei Zhang, Xin Yu, +17 authors, Zemin Zhang.
Nature, 2018 Nov 28; 564(7735). PMID: 30479382
Highly Cited.
Circulatory and respiratory changes in patients with Laennec's cirrhosis of the liver.
F A Bashour, T McConnell, W F Miller.
Am Heart J, 1967 Oct 01; 74(4). PMID: 4860251
Review.
Understanding tumor ecosystems by single-cell sequencing: promises and limitations.
Xianwen Ren, Boxi Kang, Zemin Zhang.
Genome Biol, 2018 Dec 05; 19(1). PMID: 30509292    Free PMC article.
Review.
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Ludmil B Alexandrov, Serena Nik-Zainal, +72 authors, Michael R Stratton.
Nature, 2013 Aug 16; 500(7463). PMID: 23945592    Free PMC article.
Highly Cited.
Tumor Mutational Burden and Response Rate to PD-1 Inhibition.
Mark Yarchoan, Alexander Hopkins, Elizabeth M Jaffee.
N Engl J Med, 2017 Dec 21; 377(25). PMID: 29262275    Free PMC article.
Highly Cited.
Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma.
Hanjie Li, Anne M van der Leun, +15 authors, Ido Amit.
Cell, 2019 Jan 01; 176(4). PMID: 30595452    Free PMC article.
Highly Cited.
Phenotype molding of stromal cells in the lung tumor microenvironment.
Diether Lambrechts, Els Wauters, +15 authors, Bernard Thienpont.
Nat Med, 2018 Jul 11; 24(8). PMID: 29988129
Highly Cited.
Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing.
Xinyi Guo, Yuanyuan Zhang, +16 authors, Zemin Zhang.
Nat Med, 2018 Jun 27; 24(7). PMID: 29942094
Highly Cited.
Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.
Samra Turajlic, Kevin Litchfield, +17 authors, Charles Swanton.
Lancet Oncol, 2017 Jul 12; 18(8). PMID: 28694034
Highly Cited.
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.
Matthew D Young, Thomas J Mitchell, +35 authors, Sam Behjati.
Science, 2018 Aug 11; 361(6402). PMID: 30093597    Free PMC article.
Highly Cited.
An Immune Atlas of Clear Cell Renal Cell Carcinoma.
Stéphane Chevrier, Jacob Harrison Levine, +14 authors, Bernd Bodenmiller.
Cell, 2017 May 06; 169(4). PMID: 28475899    Free PMC article.
Highly Cited.
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.
Dung T Le, Jennifer N Uram, +32 authors, Luis A Diaz.
N Engl J Med, 2015 Jun 02; 372(26). PMID: 26028255    Free PMC article.
Highly Cited.
Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors.
Huipeng Li, Elise T Courtois, +14 authors, Shyam Prabhakar.
Nat Genet, 2017 Mar 21; 49(5). PMID: 28319088
Highly Cited.
Immune Checkpoint Blockade for Breast Cancer.
April Swoboda, Rita Nanda.
Cancer Treat Res, 2018 Jan 20; 173. PMID: 29349763    Free PMC article.
Review.
Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer.
Woosung Chung, Hye Hyeon Eum, +10 authors, Woong-Yang Park.
Nat Commun, 2017 May 06; 8. PMID: 28474673    Free PMC article.
Highly Cited.
Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis.
Peter Savas, Balaji Virassamy, +23 authors, Sherene Loi.
Nat Med, 2018 Jun 27; 24(7). PMID: 29942092
Highly Cited.
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment.
Elham Azizi, Ambrose J Carr, +16 authors, Dana Pe'er.
Cell, 2018 Jul 03; 174(5). PMID: 29961579    Free PMC article.
Highly Cited.
Comprehensive T cell repertoire characterization of non-small cell lung cancer.
Alexandre Reuben, Jiexin Zhang, +55 authors, Jianjun Zhang.
Nat Commun, 2020 Feb 01; 11(1). PMID: 32001676    Free PMC article.
Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers.
Wouter Scheper, Sander Kelderman, +16 authors, Ton N Schumacher.
Nat Med, 2018 Dec 05; 25(1). PMID: 30510250
Highly Cited.
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates.
Yannick Simoni, Etienne Becht, +29 authors, Evan W Newell.
Nature, 2018 May 18; 557(7706). PMID: 29769722
Highly Cited.
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer.
Kroopa Joshi, Marc Robert de Massy, +32 authors, Benny Chain.
Nat Med, 2019 Oct 09; 25(10). PMID: 31591606    Free PMC article.
Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression.
Maria Parkhurst, Alena Gros, +4 authors, Steven A Rosenberg.
Clin Cancer Res, 2016 Nov 09; 23(10). PMID: 27827318    Free PMC article.
Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids.
Krijn K Dijkstra, Chiara M Cattaneo, +21 authors, Emile E Voest.
Cell, 2018 Aug 14; 174(6). PMID: 30100188    Free PMC article.
Highly Cited.
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade.
Livnat Jerby-Arnon, Parin Shah, +49 authors, Aviv Regev.
Cell, 2018 Nov 06; 175(4). PMID: 30388455    Free PMC article.
Highly Cited.
Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma.
Moshe Sade-Feldman, Keren Yizhak, +32 authors, Nir Hacohen.
Cell, 2018 Nov 06; 175(4). PMID: 30388456    Free PMC article.
Highly Cited.
Clonal replacement of tumor-specific T cells following PD-1 blockade.
Kathryn E Yost, Ansuman T Satpathy, +13 authors, Howard Y Chang.
Nat Med, 2019 Jul 31; 25(8). PMID: 31359002    Free PMC article.
Highly Cited.
Peripheral T cell expansion predicts tumour infiltration and clinical response.
Thomas D Wu, Shravan Madireddi, +26 authors, Jane L Grogan.
Nature, 2020 Feb 28; 579(7798). PMID: 32103181
High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy.
Carsten Krieg, Malgorzata Nowicka, +7 authors, Burkhard Becher.
Nat Med, 2018 Jan 09; 24(2). PMID: 29309059
Highly Cited.
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors.
Alexandra-Chloé Villani, Rahul Satija, +21 authors, Nir Hacohen.
Science, 2017 Apr 22; 356(6335). PMID: 28428369    Free PMC article.
Highly Cited.
Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells.
Charles-Antoine Dutertre, Etienne Becht, +27 authors, Florent Ginhoux.
Immunity, 2019 Sep 03; 51(3). PMID: 31474513
Highly Cited.
Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma.
Qiming Zhang, Yao He, +22 authors, Zemin Zhang.
Cell, 2019 Nov 02; 179(4). PMID: 31675496
Highly Cited.
Tumour-associated macrophages as treatment targets in oncology.
Alberto Mantovani, Federica Marchesi, +2 authors, Paola Allavena.
Nat Rev Clin Oncol, 2017 Jan 25; 14(7). PMID: 28117416    Free PMC article.
Highly Cited. Review.
M-1/M-2 macrophages and the Th1/Th2 paradigm.
C D Mills, K Kincaid, +2 authors, A M Hill.
J Immunol, 2000 Jun 08; 164(12). PMID: 10843666
Highly Cited.
Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq.
Qianqian Song, Gregory A Hawkins, +17 authors, Wei Zhang.
Cancer Med, 2019 Apr 30; 8(6). PMID: 31033233    Free PMC article.
Macrophage diversity enhances tumor progression and metastasis.
Bin-Zhi Qian, Jeffrey W Pollard.
Cell, 2010 Apr 08; 141(1). PMID: 20371344    Free PMC article.
Highly Cited. Review.
Top 10 Challenges in Cancer Immunotherapy.
Priti S Hegde, Daniel S Chen.
Immunity, 2020 Jan 16; 52(1). PMID: 31940268
Review.
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses.
Kelly D Moynihan, Cary F Opel, +19 authors, Darrell J Irvine.
Nat Med, 2016 Nov 01; 22(12). PMID: 27775706    Free PMC article.
Highly Cited.
The immune system as a social network.
Andreas Bergthaler, Jörg Menche.
Nat Immunol, 2017 Apr 19; 18(5). PMID: 28418389
NK Cell Exhaustion.
Jiacheng Bi, Zhigang Tian.
Front Immunol, 2017 Jul 14; 8. PMID: 28702032    Free PMC article.
Highly Cited. Review.
Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics.
Manu P Kumar, Jinyan Du, +5 authors, Andreas Raue.
Cell Rep, 2018 Nov 08; 25(6). PMID: 30404002    Free PMC article.
Highly Cited.
CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes.
Mirjana Efremova, Miquel Vento-Tormo, Sarah A Teichmann, Roser Vento-Tormo.
Nat Protoc, 2020 Feb 28; 15(4). PMID: 32103204
Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas.
Reuben Moncada, Dalia Barkley, +6 authors, Itai Yanai.
Nat Biotechnol, 2020 Jan 15; 38(3). PMID: 31932730
A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging.
Leeat Keren, Marc Bosse, +9 authors, Michael Angelo.
Cell, 2018 Sep 08; 174(6). PMID: 30193111    Free PMC article.
Highly Cited.
Intratumoral heterogeneity and clonal evolution in liver cancer.
Bojan Losic, Amanda J Craig, +25 authors, Augusto Villanueva.
Nat Commun, 2020 Jan 17; 11(1). PMID: 31941899    Free PMC article.
TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence.
Alexandre Reuben, Rachel Gittelman, +37 authors, Jianjun Zhang.
Cancer Discov, 2017 Jul 25; 7(10). PMID: 28733428    Free PMC article.
The causes and consequences of genetic heterogeneity in cancer evolution.
Rebecca A Burrell, Nicholas McGranahan, Jiri Bartek, Charles Swanton.
Nature, 2013 Sep 21; 501(7467). PMID: 24048066
Highly Cited. Review.
Biological and therapeutic impact of intratumor heterogeneity in cancer evolution.
Nicholas McGranahan, Charles Swanton.
Cancer Cell, 2015 Jan 15; 27(1). PMID: 25584892
Highly Cited. Review.
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.
Anoop P Patel, Itay Tirosh, +12 authors, Bradley E Bernstein.
Science, 2014 Jun 14; 344(6190). PMID: 24925914    Free PMC article.
Highly Cited.
Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue.
Michael J Gerdes, Christopher J Sevinsky, +28 authors, Fiona Ginty.
Proc Natl Acad Sci U S A, 2013 Jul 03; 110(29). PMID: 23818604    Free PMC article.
Highly Cited.
Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method.
Jia-Ren Lin, Mohammad Fallahi-Sichani, Peter K Sorger.
Nat Commun, 2015 Sep 25; 6. PMID: 26399630    Free PMC article.
Highly Cited.
Multiplexed ion beam imaging of human breast tumors.
Michael Angelo, Sean C Bendall, +9 authors, Garry P Nolan.
Nat Med, 2014 Mar 04; 20(4). PMID: 24584119    Free PMC article.
Highly Cited.
Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry.
Charlotte Giesen, Hao A O Wang, +11 authors, Bernd Bodenmiller.
Nat Methods, 2014 Mar 04; 11(4). PMID: 24584193
Highly Cited.
Image-based transcriptomics in thousands of single human cells at single-molecule resolution.
Nico Battich, Thomas Stoeger, Lucas Pelkmans.
Nat Methods, 2013 Oct 08; 10(11). PMID: 24097269
Highly Cited.
Imaging individual mRNA molecules using multiple singly labeled probes.
Arjun Raj, Patrick van den Bogaard, +2 authors, Sanjay Tyagi.
Nat Methods, 2008 Sep 23; 5(10). PMID: 18806792    Free PMC article.
Highly Cited.
Single-cell in situ RNA profiling by sequential hybridization.
Eric Lubeck, Ahmet F Coskun, +2 authors, Long Cai.
Nat Methods, 2014 Apr 01; 11(4). PMID: 24681720    Free PMC article.
Highly Cited.
RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells.
Kok Hao Chen, Alistair N Boettiger, +2 authors, Xiaowei Zhuang.
Science, 2015 Apr 11; 348(6233). PMID: 25858977    Free PMC article.
Highly Cited.
In situ sequencing for RNA analysis in preserved tissue and cells.
Rongqin Ke, Marco Mignardi, +4 authors, Mats Nilsson.
Nat Methods, 2013 Jul 16; 10(9). PMID: 23852452
Highly Cited.
Highly multiplexed subcellular RNA sequencing in situ.
Je Hyuk Lee, Evan R Daugharthy, +16 authors, George M Church.
Science, 2014 Mar 01; 343(6177). PMID: 24578530    Free PMC article.
Highly Cited.
Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue.
Ditte Lovatt, Brittani K Ruble, +15 authors, James Eberwine.
Nat Methods, 2014 Jan 15; 11(2). PMID: 24412976    Free PMC article.
Highly Cited.
A Systems Biology Workflow for Drug and Vaccine Repurposing: Identifying Small-Molecule BCG Mimics to Reduce or Prevent COVID-19 Mortality.
Rima Hajjo, Alexander Tropsha.
Pharm Res, 2020 Oct 08; 37(11). PMID: 33025261    Free PMC article.
Cancer-Associated Angiogenesis: The Endothelial Cell as a Checkpoint for Immunological Patrolling.
Antonio Giovanni Solimando, Simona De Summa, Angelo Vacca, Domenico Ribatti.
Cancers (Basel), 2020 Nov 19; 12(11). PMID: 33203154    Free PMC article.
Review.
Alteration in Gene Pair Correlations in Tryptophan Metabolism as a Hallmark in Cancer Diagnosis.
Meena Kishore Sakharkar, Sarinder Kaur Dhillon, +4 authors, Jian Yang.
Int J Tryptophan Res, 2020 Dec 24; 13. PMID: 33354111    Free PMC article.
Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation.
Huidong Guo, Ying-Jun Chang, +14 authors, Xiao-Jun Huang.
Cell Mol Immunol, 2021 Jan 08; 18(5). PMID: 33408344    Free PMC article.
Overcoming the challenges associated with CD3+ T-cell redirection in cancer.
Ajit Singh, Sundee Dees, Iqbal S Grewal.
Br J Cancer, 2021 Jan 21; 124(6). PMID: 33469153    Free PMC article.
Review.
The Potentiation of Anti-Tumor Immunity by Tumor Abolition with Alpha Particles, Protons, or Carbon Ion Radiation and Its Enforcement by Combination with Immunoadjuvants or Inhibitors of Immune Suppressor Cells and Checkpoint Molecules.
Yona Keisari, Itzhak Kelson.
Cells, 2021 Jan 29; 10(2). PMID: 33503958    Free PMC article.
Review.
Molecules and Mechanisms to Overcome Oxidative Stress Inducing Cardiovascular Disease in Cancer Patients.
Francesco Sabbatino, Valeria Conti, +8 authors, Stefano Pepe.
Life (Basel), 2021 Feb 13; 11(2). PMID: 33573162    Free PMC article.
Review.
GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer.
Shu Ichimiya, Hideya Onishi, +8 authors, Masafumi Nakamura.
Oncol Rep, 2021 Mar 03; 45(3). PMID: 33650666    Free PMC article.
New Insights Into the Cancer-Microbiome-Immune Axis: Decrypting a Decade of Discoveries.
Tejeshwar Jain, Prateek Sharma, +2 authors, Vikas Dudeja.
Front Immunol, 2021 Mar 13; 12. PMID: 33708214    Free PMC article.
Review.
Single-Cell Profiling to Explore Immunological Heterogeneity of Tumor Microenvironment in Breast Cancer.
Xiao Yuan, Jinxi Wang, +2 authors, Peng Zhang.
Front Immunol, 2021 Mar 16; 12. PMID: 33717201    Free PMC article.
Review.
Lymphoma Heterogeneity Unraveled by Single-Cell Transcriptomics.
Loic Ysebaert, Anne Quillet-Mary, +3 authors, Jean-Jacques Fournié.
Front Immunol, 2021 Mar 19; 12. PMID: 33732232    Free PMC article.
Review.
Cytosolic Delivery of Thiolated Neoantigen Nano-Vaccine Combined with Immune Checkpoint Blockade to Boost Anti-Cancer T Cell Immunity.
Da Zhang, Ziguo Lin, +12 authors, Xiaolong Liu.
Adv Sci (Weinh), 2021 Mar 23; 8(6). PMID: 33747739    Free PMC article.
Remodeling of Stromal Cells and Immune Landscape in Microenvironment During Tumor Progression.
Leena Arora, Durba Pal.
Front Oncol, 2021 Mar 26; 11. PMID: 33763348    Free PMC article.
Review.
Nanobody: A Small Antibody with Big Implications for Tumor Therapeutic Strategy.
Shuyang Sun, Ziqiang Ding, +9 authors, Xiaoling Lu.
Int J Nanomedicine, 2021 Apr 02; 16. PMID: 33790553    Free PMC article.
Review.
The TRAIL in the Treatment of Human Cancer: An Update on Clinical Trials.
Martin Snajdauf, Klara Havlova, +5 authors, Zuzana Strizova.
Front Mol Biosci, 2021 Apr 02; 8. PMID: 33791337    Free PMC article.
Review.
Identification of PSMD7 as a prognostic factor correlated with immune infiltration in head and neck squamous cell carcinoma.
Si Zhang, Siwei Yu, Jiulong Wang, Zhigang Cheng.
Biosci Rep, 2021 Mar 10; 41(3). PMID: 33687056    Free PMC article.
Artificial intelligence prediction model for overall survival of clear cell renal cell carcinoma based on a 21-gene molecular prognostic score system.
Qiliang Peng, Yi Shen, +4 authors, Jin Zhu.
Aging (Albany NY), 2021 Mar 10; 13(5). PMID: 33686949    Free PMC article.
The Peripheral Immune Landscape of Breast Cancer: Clinical Findings and In Vitro Models for Biomarker Discovery.
Sofia Batalha, Sofia Ferreira, Catarina Brito.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33804027    Free PMC article.
Review.
Arming Immune Cells for Battle: A Brief Journey through the Advancements of T and NK Cell Immunotherapy.
Philipp Wendel, Lisa Marie Reindl, +7 authors, Evelyn Ullrich.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33807011    Free PMC article.
Review.
Aryl Urea Based Scaffolds for Multitarget Drug Discovery in Anticancer Immunotherapies.
Celia Martín-Beltrán, Raquel Gil-Edo, +4 authors, Eva Falomir.
Pharmaceuticals (Basel), 2021 May 01; 14(4). PMID: 33917617    Free PMC article.
Combination Therapy of Novel Oncolytic Adenovirus with Anti-PD1 Resulted in Enhanced Anti-Cancer Effect in Syngeneic Immunocompetent Melanoma Mouse Model.
Mariangela Garofalo, Laura Bertinato, +6 authors, Lukasz Kuryk.
Pharmaceutics, 2021 May 01; 13(4). PMID: 33919827    Free PMC article.
The Future of Cancer Diagnosis, Treatment and Surveillance: A Systemic Review on Immunotherapy and Immuno-PET Radiotracers.
Virginia Liberini, Riccardo Laudicella, +5 authors, Désirée Deandreis.
Molecules, 2021 May 01; 26(8). PMID: 33920423    Free PMC article.
Systematic Review.
Biomechanical Properties of Cancer Cells.
Gaël Runel, Noémie Lopez-Ramirez, Julien Chlasta, Ingrid Masse.
Cells, 2021 May 01; 10(4). PMID: 33924659    Free PMC article.
Review.
Cancer neoantigens as potential targets for immunotherapy.
Weijie Ma, Brian Pham, Tianhong Li.
Clin Exp Metastasis, 2021 May 06; 39(1). PMID: 33950415    Free PMC article.
Review.
Therapeutic potential of interleukin-15 in cancer (Review).
Gheorghita Isvoranu, Mihaela Surcel, +4 authors, Marioara Chiritoiu-Butnaru.
Exp Ther Med, 2021 May 15; 22(1). PMID: 33986840    Free PMC article.
Review.
Current and Prospective Methods for Assessing Anti-Tumor Immunity in Colorectal Cancer.
Yulia I Nussbaum, Yariswamy Manjunath, +5 authors, Jonathan B Mitchem.
Int J Mol Sci, 2021 May 06; 22(9). PMID: 33946558    Free PMC article.
Review.
Identification of Hub Genes and Their Correlation With Immune Infiltration Cells in Hepatocellular Carcinoma Based on GEO and TCGA Databases.
Rui Huang, Jinying Liu, +7 authors, Kun Yang.
Front Genet, 2021 May 18; 12. PMID: 33995482    Free PMC article.
Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment.
Diwen Zhang, Zhigang Zhou, +6 authors, Jian Tu.
Front Oncol, 2021 May 25; 11. PMID: 34026612    Free PMC article.
Review.
The Orphan Nuclear Receptor Gene NR0B2 Is a Favorite Prognosis Factor Modulated by Multiple Cellular Signal Pathways in Human Liver Cancers.
Runzhi Zhu, Yanjie Tu, +7 authors, Benyi Li.
Front Oncol, 2021 Jun 01; 11. PMID: 34055653    Free PMC article.
Using four decades of FDA orphan drug designations to describe trends in rare disease drug development: substantial growth seen in development of drugs for rare oncologic, neurologic, and pediatric-onset diseases.
Kathleen L Miller, Lewis J Fermaglich, Janet Maynard.
Orphanet J Rare Dis, 2021 Jun 11; 16(1). PMID: 34107994    Free PMC article.
Immunotherapy in the Treatment of Urothelial Bladder Cancer: Insights From Single-Cell Analysis.
Jingyu Zang, Kaiyan Ye, +3 authors, Guanglei Zhuang.
Front Oncol, 2021 Jun 15; 11. PMID: 34123863    Free PMC article.
Review.
Pan-cancer characterization of lncRNA modifiers of immune microenvironment reveals clinically distinct de novo tumor subtypes.
Zicheng Zhang, Congcong Yan, +6 authors, Meng Zhou.
NPJ Genom Med, 2021 Jun 19; 6(1). PMID: 34140519    Free PMC article.
ceRNA network development and tumor-infiltrating immune cell analysis in hepatocellular carcinoma.
Li Chen, Weijie Zou, +3 authors, Caifang Ni.
Med Oncol, 2021 Jun 21; 38(7). PMID: 34148185
B Cell Orchestration of Anti-tumor Immune Responses: A Matter of Cell Localization and Communication.
Gabriela Sarti Kinker, Glauco Akelinghton Freire Vitiello, +3 authors, Tiago da Silva Medina.
Front Cell Dev Biol, 2021 Jun 25; 9. PMID: 34164398    Free PMC article.
Review.
Immunological analysis of the murine anti-CD3-induced cytokine release syndrome model and therapeutic efficacy of anti-cytokine antibodies.
Lise Nouveau, Vanessa Buatois, +4 authors, Walter G Ferlin.
Eur J Immunol, 2021 May 05; 51(8). PMID: 33945643    Free PMC article.
A Novel Risk Model Based on Lipid Metabolism-Associated Genes Predicts Prognosis and Indicates Immune Microenvironment in Breast Cancer.
Zhimin Ye, Shengmei Zou, +2 authors, Yongbin Hu.
Front Cell Dev Biol, 2021 Jul 02; 9. PMID: 34195202    Free PMC article.
The Impact of the Tumor Microenvironment on Macrophage Polarization in Cancer Metastatic Progression.
Huogang Wang, Mingo M H Yung, +2 authors, David W Chan.
Int J Mol Sci, 2021 Jul 03; 22(12). PMID: 34207286    Free PMC article.
Review.
Octogenarians' Breast Cancer Is Associated with an Unfavorable Tumor Immune Microenvironment and Worse Disease-Free Survival.
Maiko Okano, Masanori Oshi, +5 authors, Kazuaki Takabe.
Cancers (Basel), 2021 Jul 03; 13(12). PMID: 34208219    Free PMC article.
PER1 Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Ovarian Cancer.
Mali Chen, Lili Zhang, +2 authors, Ling Lv.
Front Genet, 2021 Jul 06; 12. PMID: 34220965    Free PMC article.
Crosstalk between Macrophages and Myxoid Liposarcoma Cells Increases Spreading and Invasiveness of Tumor Cells.
Michele Minopoli, Sabrina Sarno, +18 authors, Maria Vincenza Carriero.
Cancers (Basel), 2021 Jul 03; 13(13). PMID: 34209309    Free PMC article.
Immune infiltration-related N6-methyladenosine RNA methylation regulators influence the malignancy and prognosis of endometrial cancer.
Jian Ma, Di Yang, Xiao-Xin Ma.
Aging (Albany NY), 2021 Jul 08; 13(12). PMID: 34230220    Free PMC article.
Pan-Cancer Analysis of the Prognostic and Immunological Role of HSF1: A Potential Target for Survival and Immunotherapy.
Fei Chen, Yumei Fan, +4 authors, Ke Tan.
Oxid Med Cell Longev, 2021 Jul 10; 2021. PMID: 34239690    Free PMC article.
Chimeric antigen receptor- and natural killer cell receptor-engineered innate killer cells in cancer immunotherapy.
Cai Zhang, Yuan Hu, Weihua Xiao, Zhigang Tian.
Cell Mol Immunol, 2021 Jul 17; 18(9). PMID: 34267335    Free PMC article.
Review.
Hepcidin Downregulation Correlates With Disease Aggressiveness And Immune Infiltration in Liver Cancers.
Jinhu Wang, Wang Liu, +3 authors, Runzhi Zhu.
Front Oncol, 2021 Jul 20; 11. PMID: 34277457    Free PMC article.
Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour.
Seung-Hwan Jeong, Myung Jin Yang, +2 authors, Gou Young Koh.
Nat Commun, 2021 Jul 22; 12(1). PMID: 34285232    Free PMC article.
Plasma IL-8 and ICOSLG as prognostic biomarkers in glioblastoma.
Camilla Bjørnbak Holst, Ib Jarle Christensen, +4 authors, Julia Sidenius Johansen.
Neurooncol Adv, 2021 Jul 22; 3(1). PMID: 34286278    Free PMC article.
KCNN4 is a potential prognostic marker and critical factor affecting the immune status of the tumor microenvironment in kidney renal clear cell carcinoma.
Shaohua Chen, Chengbang Wang, +3 authors, Zengnan Mo.
Transl Androl Urol, 2021 Jul 24; 10(6). PMID: 34295732    Free PMC article.
HDAC Inhibitors: Dissecting Mechanisms of Action to Counter Tumor Heterogeneity.
Dimitris Karagiannis, Theodoros Rampias.
Cancers (Basel), 2021 Jul 25; 13(14). PMID: 34298787    Free PMC article.
Review.
A Comprehensive Pan-Cancer Analysis of RBM8A Based on Data Mining.
Nan Mei, Heyan Chen, +2 authors, Chunli Li.
J Oncol, 2021 Jul 31; 2021. PMID: 34326876    Free PMC article.
Identification of a Prognostic Signature Associated With the Homeobox Gene Family for Bladder Cancer.
Bingqi Dong, Jiaming Liang, +6 authors, Tiejun Yang.
Front Mol Biosci, 2021 Aug 10; 8. PMID: 34368227    Free PMC article.
Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence.
Ying Xu, Guan-Hua Su, +3 authors, Yi-Zhou Jiang.
Signal Transduct Target Ther, 2021 Aug 22; 6(1). PMID: 34417437    Free PMC article.
Review.
Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy.
Laura A Huppert, Michael D Green, +4 authors, James C Lee.
Cell Mol Immunol, 2021 Aug 22; 19(1). PMID: 34417572    Free PMC article.
Review.
GARP Correlates With Tumor-Infiltrating T-Cells and Predicts the Outcome of Gastric Cancer.
Sutian Jiang, Yifan Zhang, +5 authors, Jianfei Huang.
Front Immunol, 2021 Aug 24; 12. PMID: 34421887    Free PMC article.
Rapid Serial Immunoprofiling of the Tumor Immune Microenvironment by Fine Needle Sampling.
Juhyun Oh, Jonathan C T Carlson, +7 authors, Ralph Weissleder.
Clin Cancer Res, 2021 Jul 09; 27(17). PMID: 34233961    Free PMC article.
Therapeutic cancer vaccines revamping: technology advancements and pitfalls.
G Antonarelli, C Corti, +6 authors, G Curigliano.
Ann Oncol, 2021 Sep 10; 32(12). PMID: 34500046    Free PMC article.
Review.
Tumor Expression Profile Analysis Developed and Validated a Prognostic Model Based on Immune-Related Genes in Bladder Cancer.
Bingqi Dong, Jiaming Liang, +6 authors, Tiejun Yang.
Front Genet, 2021 Sep 14; 12. PMID: 34512722    Free PMC article.
Extending traditional antibody therapies: Novel discoveries in immunotherapy and clinical applications.
Charles Shin, Sung Soo Kim, Yong Hwa Jo.
Mol Ther Oncolytics, 2021 Sep 14; 22. PMID: 34514097    Free PMC article.
Review.
Ceruloplasmin correlates with immune infiltration and serves as a prognostic biomarker in breast cancer.
Fei Chen, Bihui Han, +7 authors, Ke Tan.
Aging (Albany NY), 2021 Aug 21; 13(16). PMID: 34413268    Free PMC article.
CARs and beyond: tailoring macrophage-based cell therapeutics to combat solid malignancies.
Shifaa M Abdin, Daniela Paasch, Michael Morgan, Nico Lachmann.
J Immunother Cancer, 2021 Sep 01; 9(8). PMID: 34462325    Free PMC article.
Immunotherapy in microsatellite instability metastatic colorectal cancer: Current status and future perspectives.
Rodrigo Motta, Santiago Cabezas-Camarero, +4 authors, Miguel J Sotelo.
J Clin Transl Res, 2021 Sep 21; 7(4). PMID: 34541365    Free PMC article.
Review.
NSCLC Biomarkers to Predict Response to Immunotherapy with Checkpoint Inhibitors (ICI): From the Cells to In Vivo Images.
Virginia Liberini, Annapaola Mariniello, +7 authors, Désirée Deandreis.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572771    Free PMC article.
Review.
A Human Pan-Cancer System Analysis of Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3).
Siming Gong, Yingjuan Duan, +3 authors, Sonja Kallendrusch.
Int J Mol Sci, 2021 Sep 29; 22(18). PMID: 34576068    Free PMC article.
The Clinical Significance of Mesenteric Lymphocytes in Human Colorectal Cancer.
Zi-Xin Wu, Fei Wang, +7 authors, Zhe-Xiong Lian.
Front Oncol, 2021 Oct 05; 11. PMID: 34604029    Free PMC article.
Identification of an Immune-Related Long Noncoding RNA Pairs Model to Predict Survival and Immune Features in Gastric Cancer.
Shenglei Song, Shuhao Liu, +5 authors, Changhua Zhang.
Front Cell Dev Biol, 2021 Oct 09; 9. PMID: 34621744    Free PMC article.
Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery.
Yang Woo Kwon, Han-Seul Jo, +4 authors, Jong Hyuk Yoon.
Front Med (Lausanne), 2021 Oct 12; 8. PMID: 34631760    Free PMC article.
Review.
Immunotherapy for Hepatocellular Carcinoma: Current Status and Future Prospects.
Zhuoyan Liu, Xuan Liu, +5 authors, Xiaotao Jiang.
Front Immunol, 2021 Oct 23; 12. PMID: 34675942    Free PMC article.
Review.
Trial watch: intratumoral immunotherapy.
Juliette Humeau, Julie Le Naour, +2 authors, Jonathan G Pol.
Oncoimmunology, 2021 Oct 23; 10(1). PMID: 34676147    Free PMC article.
Review.
Supplementation with Serum-Derived Extracellular Vesicles Reinforces Antitumor Immunity Induced by Cryo-Thermal Therapy.
Yinuo Cen, Yue Lou, +4 authors, Ping Liu.
Int J Mol Sci, 2021 Oct 24; 22(20). PMID: 34681680    Free PMC article.
Low expression of endoplasmic reticulum stress-related gene SERP1 is associated with poor prognosis and immune infiltration in skin cutaneous melanoma.
Yuchao Fan, Xiao Liang, Deshui Yu.
Aging (Albany NY), 2021 Oct 07; 13(19). PMID: 34613934    Free PMC article.
Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers.
Dazhao Peng, Cheng Wei, +5 authors, Lei Han.
Cancer Cell Int, 2021 Oct 28; 21(1). PMID: 34702252    Free PMC article.
Immunotherapy: The future of cancer treatment.
Manisha Sahu, Hemakumari Suryawanshi.
J Oral Maxillofac Pathol, 2021 Oct 28; 25(2). PMID: 34703141    Free PMC article.
Review.
Identification of Three Core Secretome Genes Associated with Immune Infiltration in High Tumor Mutation Burden Across 14 Major Solid Tumors.
Huan Wu, Hanchu Wang, Zhenyou Jiang, Yue Chen.
Int J Gen Med, 2021 Oct 28; 14. PMID: 34703282    Free PMC article.
CKS2 Overexpression Correlates with Prognosis and Immune Cell Infiltration in Lung Adenocarcinoma: A Comprehensive Study based on Bioinformatics and Experiments.
Zhiping Wang, Mengyan Zhang, +3 authors, Jiancheng Li.
J Cancer, 2021 Nov 04; 12(23). PMID: 34729099    Free PMC article.
PD1/PDL1 expression is associated with increased TIM3 expression and tumor-infiltrating T lymphocytes in fibroblastic tumors.
H Chen, H Liu, +3 authors, S Xiao.
Clin Transl Oncol, 2021 Nov 07; 24(3). PMID: 34741725
The Prognostic and Immunological Value of Guanylate-Binding Proteins in Lower-Grade Glioma: Potential Markers or Not?
Zhuang Liu, Jifeng Sun, +3 authors, Chang Liu.
Front Genet, 2021 Nov 12; 12. PMID: 34759950    Free PMC article.
Roles of HMGBs in Prognosis and Immunotherapy: A Pan-Cancer Analysis.
Tong Lin, Yingzhao Zhang, Zhimei Lin, Lisheng Peng.
Front Genet, 2021 Nov 16; 12. PMID: 34777483    Free PMC article.
The Upregulation of PLXDC2 Correlates with Immune Microenvironment Characteristics and Predicts Prognosis in Gastric Cancer.
Yang Li, Jia-Qi Li, Hai-Ping Jiang, Xin Li.
Dis Markers, 2021 Nov 16; 2021. PMID: 34777633    Free PMC article.
Radioresistance of Human Cancers: Clinical Implications of Genetic Expression Signatures.
Sven de Mey, Inès Dufait, Mark De Ridder.
Front Oncol, 2021 Nov 16; 11. PMID: 34778082    Free PMC article.
Proteomics as a Complementary Technique to Characterize Bladder Cancer.
Rubén López-Cortés, Sergio Vázquez-Estévez, Javier Álvarez Fernández, Cristina Núñez.
Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771699    Free PMC article.
Review.
Single-Cell Transcriptomic Analysis Reveals a Tumor-Reactive T Cell Signature Associated With Clinical Outcome and Immunotherapy Response In Melanoma.
Min Yan, Jing Hu, +8 authors, Xia Li.
Front Immunol, 2021 Nov 23; 12. PMID: 34804045    Free PMC article.
From Hematopoietic Stem Cell Transplantation to Chimeric Antigen Receptor Therapy: Advances, Limitations and Future Perspectives.
Elisaveta Voynova, Damian Kovalovsky.
Cells, 2021 Nov 28; 10(11). PMID: 34831068    Free PMC article.
Review.
Programmed death ligand 2 expression plays a limited role in adenocarcinomas of the gastroesophageal junction after preoperative chemotherapy.
Gerd Jomrich, Dagmar Kollmann, +10 authors, Sebastian F Schoppmann.
Eur Surg, 2021 Dec 07; 53(6). PMID: 34868284    Free PMC article.
Prognostic Significance of PD-L1 Expression In Patients With Primary Oropharyngeal Squamous Cell Carcinoma: A Meta-Analysis.
Jerry Polesel, Anna Menegaldo, +8 authors, Elisabetta Fratta.
Front Oncol, 2021 Dec 14; 11. PMID: 34900743    Free PMC article.
Systematic Review.
Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment.
Glauco Akelinghton Freire Vitiello, Wallax Augusto Silva Ferreira, Vladmir Cláudio Cordeiro de Lima, Tiago da Silva Medina.
Front Immunol, 2021 Dec 21; 12. PMID: 34925363    Free PMC article.
Review.
Combination of Lenvatinib and Pembrolizumab as Salvage Treatment for Paucicellular Variant of Anaplastic Thyroid Cancer: A Case Report.
Cristina Luongo, Tommaso Porcelli, +9 authors, Domenico Salvatore.
Curr Oncol, 2021 Dec 24; 28(6). PMID: 34940089    Free PMC article.
Kidney Cancer and Chronic Kidney Disease: Too Close for Comfort.
Pedro Caetano Pinto, Cindy Rönnau, Martin Burchardt, Ingmar Wolff.
Biomedicines, 2021 Dec 25; 9(12). PMID: 34944574    Free PMC article.
Review.
Characterization of m6A RNA Methylation Regulators Predicts Survival and Immunotherapy in Lung Adenocarcinoma.
Minggao Zhu, Yachao Cui, +8 authors, Qiang You.
Front Immunol, 2022 Jan 04; 12. PMID: 34975871    Free PMC article.
Systematic analysis of the role of SLC52A2 in multiple human cancers.
Lilong Zhang, Man Li, +4 authors, Weixing Wang.
Cancer Cell Int, 2022 Jan 08; 22(1). PMID: 34991609    Free PMC article.
Tumor-Microenvironment-Responsive Nanomedicine for Enhanced Cancer Immunotherapy.
Shaojun Peng, Fengfeng Xiao, Meiwan Chen, Huile Gao.
Adv Sci (Weinh), 2021 Nov 20; 9(1). PMID: 34796689    Free PMC article.
Review.
Hybrid Membrane Nanovaccines Combined with Immune Checkpoint Blockade to Enhance Cancer Immunotherapy.
Peiqi Zhao, Yuanlin Xu, +5 authors, Huilai Zhang.
Int J Nanomedicine, 2022 Jan 15; 17. PMID: 35027827    Free PMC article.
Tumor-Infiltrating CD4+ Central Memory T Cells Correlated with Favorable Prognosis in Oral Squamous Cell Carcinoma.
Jin Wu, Tianyi Zhang, +6 authors, Tong Su.
J Inflamm Res, 2022 Jan 18; 15. PMID: 35035226    Free PMC article.
Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors.
Yasushi Kimura, Mario Ghosn, +3 authors, Govindarajan Srimathveeralli.
Mol Ther Oncolytics, 2022 Jan 18; 24. PMID: 35036524    Free PMC article.
Review.
Defining the correlation between immune-checkpoint inhibitors-related adverse events and clinical outcomes: a narrative review.
Omar Abdihamid, Abeid Omar, Tibera Rugambwa.
Ecancermedicalscience, 2022 Jan 21; 15. PMID: 35047065    Free PMC article.
Review.
Spatial omics: Navigating to the golden era of cancer research.
Yingcheng Wu, Yifei Cheng, +2 authors, Qiang Gao.
Clin Transl Med, 2022 Jan 19; 12(1). PMID: 35040595    Free PMC article.
Review.
Insights Into the Prognostic Value and Immunological Role of NAAA in Pan-Cancer.
Da Huang, Jiayu Shen, +4 authors, Jianwei Zhou.
Front Immunol, 2022 Jan 25; 12. PMID: 35069601    Free PMC article.
Mitosis-related gene CENP-U as a potential biomarker in malignancy.
Changjian Shao, Yuanyong Wang, +6 authors, Xiaolong Yan.
Ann Transl Med, 2022 Jan 25; 9(23). PMID: 35071438    Free PMC article.
Single-cell transcriptome profiling reveals intra-tumoral heterogeneity in human chordomas.
Wanru Duan, Boyan Zhang, +7 authors, Zan Chen.
Cancer Immunol Immunother, 2022 Jan 28;. PMID: 35084549
Chordin-like 1 is a novel prognostic biomarker and correlative with immune cell infiltration in lung adenocarcinoma.
Bing Deng, Xiaorui Chen, +6 authors, Depeng Jiang.
Aging (Albany NY), 2022 Jan 13; 14(1). PMID: 35021154    Free PMC article.
Gold-Polymer Nanocomposites for Future Therapeutic and Tissue Engineering Applications.
Panangattukara Prabhakaran Praveen Kumar, Dong-Kwon Lim.
Pharmaceutics, 2022 Jan 22; 14(1). PMID: 35056967    Free PMC article.
Review.
Neurotoxicity of Tumor Immunotherapy: The Emergence of Clinical Attention.
Benxia Zhang, Xue Li, +5 authors, Yongsheng Wang.
J Oncol, 2022 Jan 29; 2022. PMID: 35087588    Free PMC article.
Review.
The screening of immune-related biomarkers for prognosis of lung adenocarcinoma.
Zhonghui Liu, Dan Sun, Qing Zhu, Xinmin Liu.
Bioengineered, 2021 Apr 20; 12(1). PMID: 33870858    Free PMC article.
Photodynamic therapy of melanoma with new, structurally similar, NIR-absorbing ruthenium (II) complexes promotes tumor growth control via distinct hallmarks of immunogenic cell death.
Prathyusha Konda, John A Roque Iii, +6 authors, Shashi Gujar.
Am J Cancer Res, 2022 Feb 11; 12(1). PMID: 35141014    Free PMC article.
Pan-Cancer Analysis Reveals the Multidimensional Expression and Prognostic and Immunologic Roles of VSTM2L in Cancer.
Shuyi Zhang, Hailin Xiong, Jiahui Yang, Xia Yuan.
Front Mol Biosci, 2022 Feb 15; 8. PMID: 35155565    Free PMC article.
Thymic Polypeptide Fraction Biomodulina T Decreases Exhausted and Terminally Differentiated EMRA T Cells in Advanced Lung Cancer Patients Treated With Platinum-Based Chemotherapy.
Gisela María Suárez, Mauricio Catalá, +15 authors, Danay Saavedra.
Front Oncol, 2022 Feb 15; 12. PMID: 35155258    Free PMC article.
ITGA5 is an independent prognostic biomarker and potential therapeutic target for laryngeal squamous cell carcinoma.
Chongchang Zhou, Yiming Shen, +4 authors, Hongxia Deng.
J Clin Lab Anal, 2022 Jan 08; 36(2). PMID: 34994984    Free PMC article.
An Immunological Perspective of Circulating Tumor Cells as Diagnostic Biomarkers and Therapeutic Targets.
Eunice Dotse, King H Lim, +2 authors, Kwan T Chow.
Life (Basel), 2022 Feb 26; 12(2). PMID: 35207611    Free PMC article.
Review.
Therapeutic DNA Vaccines against HPV-Related Malignancies: Promising Leads from Clinical Trials.
Jianming Tang, Mingzhu Li, +4 authors, Lihui Wei.
Viruses, 2022 Feb 27; 14(2). PMID: 35215833    Free PMC article.
Review.
TJP1 Contributes to Tumor Progression through Supporting Cell-Cell Aggregation and Communicating with Tumor Microenvironment in Leiomyosarcoma.
Eun-Young Lee, Minjeong Kim, +3 authors, Hye Jin You.
Mol Cells, 2021 Nov 13; 44(11). PMID: 34764231    Free PMC article.
Clinical Significance of Tumor-Infiltrating Conventional and Plasmacytoid Dendritic Cells in Pancreatic Ductal Adenocarcinoma.
Ioana Plesca, Iva Benešová, +12 authors, Marc Schmitz.
Cancers (Basel), 2022 Mar 11; 14(5). PMID: 35267524    Free PMC article.
Immune checkpoint silencing using RNAi-incorporated nanoparticles enhances antitumor immunity and therapeutic efficacy compared with antibody-based approaches.
Ji Eun Won, Youngseon Byeon, +7 authors, Hee Dong Han.
J Immunother Cancer, 2022 Mar 02; 10(2). PMID: 35228265    Free PMC article.
Upregulation of IGF2BP2 Promotes Oral Squamous Cell Carcinoma Progression That Is Related to Cell Proliferation, Metastasis and Tumor-Infiltrating Immune Cells.
Lijie Zhou, Hongyu Li, +4 authors, Shuai He.
Front Oncol, 2022 Mar 19; 12. PMID: 35299748    Free PMC article.
Advances in High Throughput Proteomics Profiling in Establishing Potential Biomarkers for Gastrointestinal Cancer.
Md Zahirul Islam Khan, Shing Yau Tam, Helen Ka Wai Law.
Cells, 2022 Mar 26; 11(6). PMID: 35326424    Free PMC article.
Review.
Shock Waves Enhance Expression of Glycosphingolipid Tumor Antigen on Renal Cell Carcinoma: Dynamics of Physically Unmasking Hidden Intracellular Markers Independent of Gene-Signaling Pathways.
Nushin Hosano, Zahra Moosavi-Nejad, Makoto Satoh, Hamid Hosano.
Biomedicines, 2022 Mar 26; 10(3). PMID: 35327347    Free PMC article.
Functional antigen processing and presentation mechanism as a prerequisite factor of response to treatment with dendritic cell vaccines and anti-PD-1 in preclinical murine LLC1 and GL261 tumor models.
Karolina Žilionytė, Ugnė Bagdzevičiūtė, +5 authors, Vita Pašukonienė.
Cancer Immunol Immunother, 2022 Apr 03;. PMID: 35364740
Bladder cancer cells shift rapidly and spontaneously to cisplatin-resistant oxidative phosphorylation that is trackable in real time.
Tong Xu, Jason A Junge, +11 authors, Amir Goldkorn.
Sci Rep, 2022 Apr 03; 12(1). PMID: 35365706    Free PMC article.
Transcriptional and post-transcriptional regulation of checkpoint genes on the tumour side of the immunological synapse.
Paula Dobosz, Przemysław A Stempor, Miguel Ramírez Moreno, Natalia A Bulgakova.
Heredity (Edinb), 2022 Apr 24;. PMID: 35459932
Development and Validation of Novel Prognostic Models for Immune-Related Genes in Osteosarcoma.
Junqing Li, Li Su, +6 authors, Huimin Zhu.
Front Mol Biosci, 2022 Apr 26; 9. PMID: 35463956    Free PMC article.
The Prognostic Value and Immune Infiltration of USP10 in Pan-Cancer: A Potential Therapeutic Target.
Dacheng Gao, Zhiwen Zhang, +8 authors, Zengguang Xu.
Front Oncol, 2022 Apr 19; 12. PMID: 35433424    Free PMC article.
Improving ovarian cancer treatment decision using a novel risk predictive tool.
Zhenyi Xu, Jiali Song, +5 authors, Yan Hou.
Aging (Albany NY), 2022 Apr 20; 14(8). PMID: 35439731    Free PMC article.
Development of Cancer Immunotherapies.
Diana C DeLucia, John K Lee.
Cancer Treat Res, 2022 May 14; 183. PMID: 35551655
Probing immune infiltration dynamics in cancer by in vivo imaging.
Thomas S C Ng, Harris H Allen, Mohammad Rashidian, Miles A Miller.
Curr Opin Chem Biol, 2022 Feb 27; 67. PMID: 35219177    Free PMC article.
Review.
Disrupting Mechanisms that Regulate Genomic Repeat Elements to Combat Cancer and Drug Resistance.
Chames Kermi, Lena Lau, Azar Asadi Shahmirzadi, Marie Classon.
Front Cell Dev Biol, 2022 May 24; 10. PMID: 35602594    Free PMC article.
Systematic Review.
Roles of exosomal circRNAs in tumour immunity and cancer progression.
Baojing Tuo, Zhuang Chen, +4 authors, Zhenqiang Sun.
Cell Death Dis, 2022 Jun 09; 13(6). PMID: 35676257
Review.
Prognostic and tumor immunity implication of inflammatory bowel disease-associated genes in colorectal cancer.
Di Wang, Biao Xie.
Eur J Med Res, 2022 Jun 14; 27(1). PMID: 35698180
Recent advances in porous nanomaterials-based drug delivery systems for cancer immunotherapy.
Su-Ran Li, Fang-Yi Huo, +4 authors, Lin-Lin Bu.
J Nanobiotechnology, 2022 Jun 15; 20(1). PMID: 35701847
Review.