Review
. 2020 Jul; 12(7):.
doi: 10.3390/pharmaceutics12070663.

Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy

Lukas Amon 1 Lukas Hatscher 1 Lukas Heger 1 Diana Dudziak 1 Christian H K Lehmann 1 
Affiliations
  • PMID: 32674488
  •     781 References
  •     8 citations

Abstract

The onset of checkpoint inhibition revolutionized the treatment of cancer. However, studies from the last decade suggested that the sole enhancement of T cell functionality might not suffice to fight malignancies in all individuals. Dendritic cells (DCs) are not only part of the innate immune system, but also generals of adaptive immunity and they orchestrate the de novo induction of tolerogenic and immunogenic T cell responses. Thus, combinatorial approaches addressing DCs and T cells in parallel represent an attractive strategy to achieve higher response rates across patients. However, this requires profound knowledge about the dynamic interplay of DCs, T cells, other immune and tumor cells. Here, we summarize the DC subsets present in mice and men and highlight conserved and divergent characteristics between different subsets and species. Thereby, we supply a resource of the molecular players involved in key functional features of DCs ranging from their sentinel function, the translation of the sensed environment at the DC:T cell interface to the resulting specialized T cell effector modules, as well as the influence of the tumor microenvironment on the DC function. As of today, mostly monocyte derived dendritic cells (moDCs) are used in autologous cell therapies after tumor antigen loading. While showing encouraging results in a fraction of patients, the overall clinical response rate is still not optimal. By disentangling the general aspects of DC biology, we provide rationales for the design of next generation DC vaccines enabling to exploit and manipulate the described pathways for the purpose of cancer immunotherapy in vivo. Finally, we discuss how DC-based vaccines might synergize with checkpoint inhibition in the treatment of malignant diseases.

Keywords: T cells; antigen targeting; cancer therapy; checkpoint inhibition; dendritic cells; pattern recognition receptors; tumor microenvironment; vaccination.

Antitumor activity of liposomal ErbB2/HER2 epitope peptide-based vaccine constructs incorporating TLR agonists and mannose receptor targeting.
Jean-Sébastien Thomann, Béatrice Heurtault, +5 authors, Benoît Frisch.
Biomaterials, 2011 Apr 09; 32(20). PMID: 21474175
Therapeutic strategies for the costimulatory molecule OX40 in T-cell-mediated immunity.
Yu Fu, Qing Lin, Zhirong Zhang, Ling Zhang.
Acta Pharm Sin B, 2020 Mar 07; 10(3). PMID: 32140389    Free PMC article.
Review.
Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.
Alison Taylor, James A Harker, +3 authors, Christopher E Rudd.
Immunity, 2016 Feb 18; 44(2). PMID: 26885856    Free PMC article.
Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic Cells.
Gerty Schreibelt, Kalijn F Bol, +25 authors, I Jolanda M de Vries.
Clin Cancer Res, 2015 Dec 30; 22(9). PMID: 26712687
Highly Cited.
IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance.
David H Munn, Andrew L Mellor.
Trends Immunol, 2016 Feb 04; 37(3). PMID: 26839260    Free PMC article.
Highly Cited. Review.
Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo.
Phyllis-Jean Linton, Beverly Bautista, +5 authors, Linda M Bradley.
J Exp Med, 2003 Apr 02; 197(7). PMID: 12668647    Free PMC article.
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization.
Wenxiang Sun, Yang Li, +7 authors, Zhengfan Jiang.
Proc Natl Acad Sci U S A, 2009 May 13; 106(21). PMID: 19433799    Free PMC article.
Highly Cited.
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.
Leticia Corrales, Laura Hix Glickman, +10 authors, Thomas F Gajewski.
Cell Rep, 2015 May 12; 11(7). PMID: 25959818    Free PMC article.
Highly Cited.
TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification.
Marina Oldenburg, Anne Krüger, +15 authors, Carsten J Kirschning.
Science, 2012 Jul 24; 337(6098). PMID: 22821982
Highly Cited.
CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.
K Saoulli, S Y Lee, +8 authors, T H Watts.
J Exp Med, 1998 Jun 10; 187(11). PMID: 9607925    Free PMC article.
Anti-Drug Antibodies: Emerging Approaches to Predict, Reduce or Reverse Biotherapeutic Immunogenicity.
Kathleen P Pratt.
Antibodies (Basel), 2018 May 31; 7(2). PMID: 31544871    Free PMC article.
Review.
Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.
Stefani Spranger, Daisy Dai, Brendan Horton, Thomas F Gajewski.
Cancer Cell, 2017 May 10; 31(5). PMID: 28486109    Free PMC article.
Highly Cited.
Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.
L Zitvogel, J I Mayordomo, +4 authors, W J Storkus.
J Exp Med, 1996 Jan 01; 183(1). PMID: 8551248    Free PMC article.
Highly Cited.
Twelve-year survival and immune correlates in dendritic cell-vaccinated melanoma patients.
Stefanie Gross, Michael Erdmann, +12 authors, Beatrice Schuler-Thurner.
JCI Insight, 2017 Apr 20; 2(8). PMID: 28422751    Free PMC article.
Imiquimod and S-27609 as adjuvants of DNA vaccination in a transgenic murine model of HER2/neu-positive mammary carcinoma.
A Smorlesi, F Papalini, +3 authors, M Provinciali.
Gene Ther, 2005 Jun 10; 12(17). PMID: 15944732
Induction of tumor-specific cytotoxic T lymphocytes in cancer patients by autologous tumor RNA-transfected dendritic cells.
Smita K Nair, Michael Morse, +4 authors, H Kim Lyerly.
Ann Surg, 2002 Mar 30; 235(4). PMID: 11923611    Free PMC article.
Therapeutic Cancer Vaccination with Ex Vivo RNA-Transfected Dendritic Cells-An Update.
Jan Dörrie, Niels Schaft, Gerold Schuler, Beatrice Schuler-Thurner.
Pharmaceutics, 2020 Jan 26; 12(2). PMID: 31979205    Free PMC article.
Review.
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade.
Juan Fu, David B Kanne, +16 authors, Young Kim.
Sci Transl Med, 2015 Apr 17; 7(283). PMID: 25877890    Free PMC article.
Highly Cited.
Dendritic cells loaded with killed allogeneic melanoma cells can induce objective clinical responses and MART-1 specific CD8+ T-cell immunity.
Anna K Palucka, Hideki Ueno, +5 authors, Jacques Banchereau.
J Immunother, 2006 Sep 15; 29(5). PMID: 16971810
A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with meglumine antimoniate for the treatment of cutaneous leishmaniasis.
Evaldo Nascimento, Demetrios F Fernandes, +11 authors, Franco M Piazza.
Vaccine, 2010 Aug 07; 28(40). PMID: 20688040
Mature dendritic cells use endocytic receptors to capture and present antigens.
Craig D Platt, Jessica K Ma, +5 authors, Lélia Delamarre.
Proc Natl Acad Sci U S A, 2010 Feb 10; 107(9). PMID: 20142498    Free PMC article.
Pitfalls in determining the cytokine profile of human T cells.
Ingrid Olsen, Ludvig M Sollid.
J Immunol Methods, 2013 Feb 19; 390(1-2). PMID: 23416458
Rational Design of Adjuvant for Skin Delivery: Conjugation of Synthetic β-Glucan Dectin-1 Agonist to Protein Antigen.
Agnese Donadei, Simona Gallorini, +3 authors, Barbara C Baudner.
Mol Pharm, 2015 Apr 14; 12(5). PMID: 25867449
Dendritic cells in cancer immunology and immunotherapy.
Stefanie K Wculek, Francisco J Cueto, +3 authors, David Sancho.
Nat Rev Immunol, 2019 Aug 31; 20(1). PMID: 31467405
Highly Cited. Review.
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression.
Chih-Hao Chang, Jing Qiu, +11 authors, Erika L Pearce.
Cell, 2015 Sep 01; 162(6). PMID: 26321679    Free PMC article.
Highly Cited.
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Estelle Bettelli, Yijun Carrier, +5 authors, Vijay K Kuchroo.
Nature, 2006 May 02; 441(7090). PMID: 16648838
Highly Cited.
CD4+ T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness.
Tomasz Ahrends, Aldo Spanjaard, +5 authors, Jannie Borst.
Immunity, 2017 Nov 12; 47(5). PMID: 29126798
Highly Cited.
Shared Transcriptional Control of Innate Lymphoid Cell and Dendritic Cell Development.
Prachi Bagadia, Xiao Huang, Tian-Tian Liu, Kenneth M Murphy.
Annu Rev Cell Dev Biol, 2019 Jul 10; 35. PMID: 31283378    Free PMC article.
Review.
Expression of costimulatory ligand CD70 on steady-state dendritic cells breaks CD8+ T cell tolerance and permits effective immunity.
Anna M Keller, Anita Schildknecht, +2 authors, Jannie Borst.
Immunity, 2008 Dec 09; 29(6). PMID: 19062317
Plasmacytoid dendritic cells support melanoma progression by promoting Th2 and regulatory immunity through OX40L and ICOSL.
Caroline Aspord, Marie-Therese Leccia, Julie Charles, Joel Plumas.
Cancer Immunol Res, 2014 Apr 30; 1(6). PMID: 24778133
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
Marc Veldhoen, Richard J Hocking, +2 authors, Brigitta Stockinger.
Immunity, 2006 Feb 14; 24(2). PMID: 16473830
Highly Cited.
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens.
Matthew M Gubin, Xiuli Zhang, +24 authors, Robert D Schreiber.
Nature, 2014 Nov 28; 515(7528). PMID: 25428507    Free PMC article.
Highly Cited.
Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic T cell responses in the absence of systemic side effects.
Tazio Storni, Christiane Ruedl, +3 authors, Martin F Bachmann.
J Immunol, 2004 Jan 22; 172(3). PMID: 14734761
Topography of cancer-associated immune cells in human solid tumors.
Jakob Nikolas Kather, Meggy Suarez-Carmona, +17 authors, Niels Halama.
Elife, 2018 Sep 05; 7. PMID: 30179157    Free PMC article.
Highly Cited.
DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.
Christian H K Lehmann, Anna Baranska, +15 authors, Diana Dudziak.
J Exp Med, 2017 Apr 09; 214(5). PMID: 28389502    Free PMC article.
An alternative signal 3: CD8⁺ T cell memory independent of IL-12 and type I IFN is dependent on CD27/OX40 signaling.
Phillip J Sanchez, Ross M Kedl.
Vaccine, 2011 Dec 20; 30(6). PMID: 22178730    Free PMC article.
Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation.
Juliette Mouriès, Gabriel Moron, +3 authors, Claude Leclerc.
Blood, 2008 Aug 14; 112(9). PMID: 18698004    Free PMC article.
Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania.
Beatriz León, María López-Bravo, Carlos Ardavín.
Immunity, 2007 Apr 07; 26(4). PMID: 17412618
Highly Cited.
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts.
Daniel Torralba, Francesc Baixauli, +13 authors, Francisco Sánchez-Madrid.
Nat Commun, 2018 Jul 10; 9(1). PMID: 29985392    Free PMC article.
Highly Cited.
ICOS mediates the generation and function of CD4+CD25+Foxp3+ regulatory T cells conveying respiratory tolerance.
Mandy Busse, Mathias Krech, +2 authors, Gesine Hansen.
J Immunol, 2012 Jul 21; 189(4). PMID: 22815292
IL-12, but not IFN-alpha, promotes STAT4 activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene.
Meredith E Persky, Kenneth M Murphy, J David Farrar.
J Immunol, 2004 Dec 22; 174(1). PMID: 15611252
TLR8 deficiency leads to autoimmunity in mice.
Olivier Demaria, Philippe P Pagni, +7 authors, Lena Alexopoulou.
J Clin Invest, 2010 Sep 03; 120(10). PMID: 20811154    Free PMC article.
Restoring function in exhausted CD8 T cells during chronic viral infection.
Daniel L Barber, E John Wherry, +5 authors, Rafi Ahmed.
Nature, 2005 Dec 31; 439(7077). PMID: 16382236
Highly Cited.
GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells.
Julie Helft, Jan Böttcher, +5 authors, Caetano Reis e Sousa.
Immunity, 2015 Jun 18; 42(6). PMID: 26084029
Highly Cited.
Type I IFNs control antigen retention and survival of CD8α(+) dendritic cells after uptake of tumor apoptotic cells leading to cross-priming.
Silvia Lorenzi, Fabrizio Mattei, +7 authors, Giovanna Schiavoni.
J Immunol, 2011 Mar 29; 186(9). PMID: 21441457
Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow.
Andreas Schlitzer, V Sivakamasundari, +13 authors, Florent Ginhoux.
Nat Immunol, 2015 Jun 10; 16(7). PMID: 26054720
Highly Cited.
TGF-β upregulates CD70 expression and induces exhaustion of effector memory T cells in B-cell non-Hodgkin's lymphoma.
Z-Z Yang, D M Grote, +6 authors, S M Ansell.
Leukemia, 2014 Feb 27; 28(9). PMID: 24569779    Free PMC article.
Antibody-antigen-adjuvant conjugates enable co-delivery of antigen and adjuvant to dendritic cells in cis but only have partial targeting specificity.
Martin Kreutz, Benoit Giquel, +5 authors, Sandra S Diebold.
PLoS One, 2012 Jul 19; 7(7). PMID: 22808118    Free PMC article.
Induction of endoplasmic reticulum-endosome fusion for antigen cross-presentation induced by poly (γ-glutamic acid) nanoparticles.
Yohei Mukai, Tomoyo Yoshinaga, +7 authors, Shinsaku Nakagawa.
J Immunol, 2011 Nov 19; 187(12). PMID: 22095716
HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway.
Ramunas M Vabulas, Parviz Ahmad-Nejad, +3 authors, Hermann Wagner.
J Biol Chem, 2002 Feb 14; 277(17). PMID: 11842086
Highly Cited.
Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions.
Kiki Tesselaar, Ramon Arens, +5 authors, René A W van Lier.
Nat Immunol, 2002 Dec 07; 4(1). PMID: 12469117
The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity.
Antonio P Baptista, Anita Gola, +6 authors, Ronald N Germain.
Immunity, 2019 May 06; 50(5). PMID: 31053504
Genetic basis for clinical response to CTLA-4 blockade in melanoma.
Alexandra Snyder, Vladimir Makarov, +18 authors, Timothy A Chan.
N Engl J Med, 2014 Nov 20; 371(23). PMID: 25409260    Free PMC article.
Highly Cited.
Mature human Langerhans cells derived from CD34+ hematopoietic progenitors stimulate greater cytolytic T lymphocyte activity in the absence of bioactive IL-12p70, by either single peptide presentation or cross-priming, than do dermal-interstitial or monocyte-derived dendritic cells.
Gudrun Ratzinger, Jan Baggers, +6 authors, James W Young.
J Immunol, 2004 Aug 06; 173(4). PMID: 15294997
Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses.
Kota Sato, Xiao-li Yang, +7 authors, Kiyoshi Ariizumi.
J Biol Chem, 2006 Oct 20; 281(50). PMID: 17050534
Highly Cited.
OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology.
Naoto Ishii, Takeshi Takahashi, Pejman Soroosh, Kazuo Sugamura.
Adv Immunol, 2010 Jun 01; 105. PMID: 20510730
Review.
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.
Yumiko Imai, Keiji Kuba, +22 authors, Josef M Penninger.
Cell, 2008 Apr 22; 133(2). PMID: 18423196    Free PMC article.
Highly Cited.
Nod2-dependent Th2 polarization of antigen-specific immunity.
Joao Gamelas Magalhaes, Jörg H Fritz, +6 authors, Dana J Philpott.
J Immunol, 2008 Nov 20; 181(11). PMID: 19017983
Immune Adjuvant Effect of Molecularly-defined Toll-Like Receptor Ligands.
Deana N Toussi, Paola Massari.
Vaccines (Basel), 2014 Jan 01; 2(2). PMID: 26344622    Free PMC article.
Review.
Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.
David Sancho, Diego Mourão-Sá, +5 authors, Caetano Reis e Sousa.
J Clin Invest, 2008 May 24; 118(6). PMID: 18497879    Free PMC article.
Highly Cited.
Differential contribution of three immune checkpoint (VISTA, CTLA-4, PD-1) pathways to antitumor responses against squamous cell carcinoma.
Yuta Kondo, Tatsukuni Ohno, +3 authors, Miyuki Azuma.
Oral Oncol, 2016 May 22; 57. PMID: 27208845
CD40 stimulation accelerates deletion of tumor-specific CD8(+) T cells in the absence of tumor-antigen vaccination.
R M Kedl, M Jordan, +3 authors, S Dow.
Proc Natl Acad Sci U S A, 2001 Aug 30; 98(19). PMID: 11526222    Free PMC article.
Inducing and expanding regulatory T cell populations by foreign antigen.
Karsten Kretschmer, Irina Apostolou, +3 authors, Harald von Boehmer.
Nat Immunol, 2005 Oct 26; 6(12). PMID: 16244650
Highly Cited.
Dendritic cell (DC) based therapy for cervical cancer: use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]:poly [C(12)U] (Ampligen R).
M Adams, H Navabi, +5 authors, M Mason.
Vaccine, 2003 Jan 18; 21(7-8). PMID: 12531360
Review.
Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potential.
Koen van de Ven, Jannie Borst.
Immunotherapy, 2015 Jun 23; 7(6). PMID: 26098609
Review.
Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells.
J M Curtsinger, C S Schmidt, +4 authors, M F Mescher.
J Immunol, 1999 Mar 27; 162(6). PMID: 10092777
Highly Cited.
During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion.
Jenny Hendriks, Yanling Xiao, +4 authors, Jannie Borst.
J Immunol, 2005 Jul 22; 175(3). PMID: 16034107
Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.
Kanako L Lewis, Michele L Caton, +11 authors, Boris Reizis.
Immunity, 2011 Oct 25; 35(5). PMID: 22018469    Free PMC article.
Highly Cited.
Signaling by myeloid C-type lectin receptors in immunity and homeostasis.
David Sancho, Caetano Reis e Sousa.
Annu Rev Immunol, 2012 Jan 10; 30. PMID: 22224766    Free PMC article.
Highly Cited. Review.
An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells.
Ivan Zanoni, Yunhao Tan, +8 authors, Jonathan C Kagan.
Science, 2016 Apr 23; 352(6290). PMID: 27103670    Free PMC article.
Highly Cited.
Sequential analysis of CD34+ and CD34- cell subsets in peripheral blood and leukapheresis products from breast cancer patients mobilized with SCF plus G-CSF and cyclophosphamide.
P Menéndez, F Prósper, +7 authors, A Orfao.
Leukemia, 2001 Mar 10; 15(3). PMID: 11237067
Targeted delivery of tumor antigens to activated dendritic cells via CD11c molecules induces potent antitumor immunity in mice.
Huafeng Wei, Suhui Wang, +8 authors, Yajun Guo.
Clin Cancer Res, 2009 Jul 09; 15(14). PMID: 19584156
Immune checkpoint inhibitors: recent progress and potential biomarkers.
Pramod Darvin, Salman M Toor, Varun Sasidharan Nair, Eyad Elkord.
Exp Mol Med, 2018 Dec 14; 50(12). PMID: 30546008    Free PMC article.
Highly Cited. Review.
Migratory, and not lymphoid-resident, dendritic cells maintain peripheral self-tolerance and prevent autoimmunity via induction of iTreg cells.
Caterina Vitali, Francesca Mingozzi, +6 authors, Francesca Granucci.
Blood, 2012 Jul 05; 120(6). PMID: 22760781
Efficient MHC class I presentation by controlled intracellular trafficking of antigens in octaarginine-modified liposomes.
Takashi Nakamura, Rumiko Moriguchi, +2 authors, Hideyoshi Harashima.
Mol Ther, 2008 Jun 19; 16(8). PMID: 18560420
STING signaling and host defense against microbial infection.
Jeonghyun Ahn, Glen N Barber.
Exp Mol Med, 2019 Dec 13; 51(12). PMID: 31827069    Free PMC article.
Review.
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells.
Brian T Edelson, Wumesh KC, +14 authors, Kenneth M Murphy.
J Exp Med, 2010 Mar 31; 207(4). PMID: 20351058    Free PMC article.
Highly Cited.
Mapping the human DC lineage through the integration of high-dimensional techniques.
Peter See, Charles-Antoine Dutertre, +33 authors, Florent Ginhoux.
Science, 2017 May 06; 356(6342). PMID: 28473638    Free PMC article.
Highly Cited.
Notch2-dependent DC2s mediate splenic germinal center responses.
Carlos G Briseño, Ansuman T Satpathy, +7 authors, Kenneth M Murphy.
Proc Natl Acad Sci U S A, 2018 Oct 04; 115(42). PMID: 30279176    Free PMC article.
A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation.
Antonio Gregorio Dias Junior, Natalia G Sampaio, Jan Rehwinkel.
Trends Microbiol, 2018 Sep 12; 27(1). PMID: 30201512    Free PMC article.
Review.
The C-type lectin-like domain superfamily.
Alex N Zelensky, Jill E Gready.
FEBS J, 2005 Dec 13; 272(24). PMID: 16336259
Highly Cited. Review.
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.
Bo Zhong, Yan Yang, +8 authors, Hong-Bing Shu.
Immunity, 2008 Sep 27; 29(4). PMID: 18818105
Highly Cited.
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.
Naiyer A Rizvi, Matthew D Hellmann, +21 authors, Timothy A Chan.
Science, 2015 Mar 15; 348(6230). PMID: 25765070    Free PMC article.
Highly Cited.
Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response.
Assaf Marcus, Amy J Mao, +3 authors, David H Raulet.
Immunity, 2018 Oct 18; 49(4). PMID: 30332631    Free PMC article.
Highly Cited.
Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells.
Geoffrey L Stephens, Rebecca S McHugh, +5 authors, Ethan M Shevach.
J Immunol, 2004 Oct 08; 173(8). PMID: 15470044
Highly Cited.
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma.
Eliezer M Van Allen, Diana Miao, +19 authors, Levi A Garraway.
Science, 2015 Sep 12; 350(6257). PMID: 26359337    Free PMC article.
Highly Cited.
CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1.
S Flynn, K M Toellner, +2 authors, P Lane.
J Exp Med, 1998 Jul 22; 188(2). PMID: 9670042    Free PMC article.
Highly Cited.
DCIR2+ cDC2 DCs and Zbtb32 Restore CD4+ T-Cell Tolerance and Inhibit Diabetes.
Jeffrey D Price, Chie Hotta-Iwamura, +2 authors, Kristin V Tarbell.
Diabetes, 2015 Jun 14; 64(10). PMID: 26070317    Free PMC article.
A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments.
Kevin C Barry, Joy Hsu, +19 authors, Matthew F Krummel.
Nat Med, 2018 Jun 27; 24(8). PMID: 29942093    Free PMC article.
Highly Cited.
Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: assessment of correlation between clinical response and vaccine parameters.
Lotte Engell-Noerregaard, Troels Holz Hansen, +2 authors, Inge Marie Svane.
Cancer Immunol Immunother, 2008 Aug 23; 58(1). PMID: 18719915
Review.
Help for cytotoxic-T-cell responses is mediated by CD40 signalling.
S R Bennett, F R Carbone, +3 authors, W R Heath.
Nature, 1998 Jun 12; 393(6684). PMID: 9624004
Highly Cited.
Mechanisms of NOD-like receptor-associated inflammasome activation.
Haitao Wen, Edward A Miao, Jenny P-Y Ting.
Immunity, 2013 Sep 24; 39(3). PMID: 24054327    Free PMC article.
Highly Cited. Review.
Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia.
Sébastien Anguille, Ann L Van de Velde, +28 authors, Zwi N Berneman.
Blood, 2017 Aug 24; 130(15). PMID: 28830889    Free PMC article.
Highly Cited.
Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells.
F O Nestle, S Alijagic, +5 authors, D Schadendorf.
Nat Med, 1998 Mar 21; 4(3). PMID: 9500607
Highly Cited.
Dendritic cell immunoactivating receptor, a novel C-type lectin immunoreceptor, acts as an activating receptor through association with Fc receptor gamma chain.
Nobuo Kanazawa, Kei Tashiro, Kayo Inaba, Yoshiki Miyachi.
J Biol Chem, 2003 Jun 05; 278(35). PMID: 12777403
Trogocytosis of CD80 and CD86 by induced regulatory T cells.
Peng Gu, Julia Fang Gao, +3 authors, Li Zhang.
Cell Mol Immunol, 2012 Feb 07; 9(2). PMID: 22307040    Free PMC article.
Tumor-derived autophagosome vaccine: mechanism of cross-presentation and therapeutic efficacy.
Yuhuan Li, Li-Xin Wang, +6 authors, Hong-Ming Hu.
Clin Cancer Res, 2011 Nov 10; 17(22). PMID: 22068657    Free PMC article.
The glucocorticoid-induced TNF receptor-related protein (GITR)-GITR ligand pathway acts as a mediator of cutaneous dendritic cell migration and promotes T cell-mediated acquired immunity.
Yosuke Kamimura, Hideyuki Iwai, +2 authors, Miyuki Azuma.
J Immunol, 2009 Feb 24; 182(5). PMID: 19234165
Cell depletion in mice that express diphtheria toxin receptor under the control of SiglecH encompasses more than plasmacytoid dendritic cells.
Melissa Swiecki, Yaming Wang, +7 authors, Marco Colonna.
J Immunol, 2014 Apr 01; 192(9). PMID: 24683186    Free PMC article.
Cutting edge: Autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells.
Maria L Belladonna, Claudia Volpi, +8 authors, Paolo Puccetti.
J Immunol, 2008 Oct 04; 181(8). PMID: 18832670
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.
Julie R Brahmer, Scott S Tykodi, +23 authors, Jon M Wigginton.
N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658128    Free PMC article.
Highly Cited.
The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses.
Mireille H Lahoud, Anna I Proietto, +14 authors, Irina Caminschi.
J Immunol, 2009 Jun 06; 182(12). PMID: 19494282
A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-κB signaling pathways.
Neil Warner, Aaron Burberry, +4 authors, Gabriel Núñez.
Sci Signal, 2013 Jan 17; 6(258). PMID: 23322906    Free PMC article.
Clonal analysis of human dendritic cell progenitor using a stromal cell culture.
Jaeyop Lee, Gaëlle Breton, +4 authors, Kang Liu.
J Immunol Methods, 2015 Jun 10; 425. PMID: 26056939    Free PMC article.
Hallmarks of cancer: the next generation.
Douglas Hanahan, Robert A Weinberg.
Cell, 2011 Mar 08; 144(5). PMID: 21376230
Highly Cited. Review.
IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17.
Curtis J Henry, David A Ornelles, +2 authors, Elizabeth M Hiltbold.
J Immunol, 2008 Dec 04; 181(12). PMID: 19050277    Free PMC article.
PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+ CD25(Hi) regulatory T cells.
Wenshi Wang, Roy Lau, +3 authors, Jeffrey Weber.
Int Immunol, 2009 Aug 05; 21(9). PMID: 19651643    Free PMC article.
Highly Cited.
Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells.
Marie-Clotilde Rissoan, Thomas Duhen, +5 authors, Elizabeth E M Bates.
Blood, 2002 Oct 18; 100(9). PMID: 12384430
STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation.
Henrique Lemos, Eslam Mohamed, +5 authors, Andrew L Mellor.
Cancer Res, 2016 Mar 12; 76(8). PMID: 26964621    Free PMC article.
Highly Cited.
Cross-presentation by dendritic cells.
Olivier P Joffre, Elodie Segura, Ariel Savina, Sebastian Amigorena.
Nat Rev Immunol, 2012 Jul 14; 12(8). PMID: 22790179
Highly Cited. Review.
The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8.
Prafullakumar Tailor, Tomohiko Tamura, +5 authors, Keiko Ozato.
Immunity, 2007 Aug 19; 27(2). PMID: 17702615    Free PMC article.
Type I interferon is selectively required by dendritic cells for immune rejection of tumors.
Mark S Diamond, Michelle Kinder, +9 authors, Robert D Schreiber.
J Exp Med, 2011 Sep 21; 208(10). PMID: 21930769    Free PMC article.
Highly Cited.
An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases.
Yang Liu, William N Crowe, +4 authors, Dawen Zhao.
Nat Commun, 2019 Nov 11; 10(1). PMID: 31704921    Free PMC article.
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.
Miriam Merad, Priyanka Sathe, +2 authors, Arthur Mortha.
Annu Rev Immunol, 2013 Mar 23; 31. PMID: 23516985    Free PMC article.
Highly Cited. Review.
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation.
Nikolaos Patsoukis, Kankana Bardhan, +9 authors, Vassiliki A Boussiotis.
Nat Commun, 2015 Mar 27; 6. PMID: 25809635    Free PMC article.
Highly Cited.
Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells.
Genc Basha, Tatiana I Novobrantseva, +12 authors, Pieter R Cullis.
Mol Ther, 2011 Oct 06; 19(12). PMID: 21971424    Free PMC article.
Novel vaccines targeting dendritic cells by coupling allergoids to mannan.
Cristina Benito-Villalvilla, Irene Soria, José Luis Subiza, Oscar Palomares.
Allergo J Int, 2018 Dec 14; 27(8). PMID: 30546997    Free PMC article.
Review.
Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells.
Charles-Antoine Dutertre, Etienne Becht, +27 authors, Florent Ginhoux.
Immunity, 2019 Sep 03; 51(3). PMID: 31474513
Highly Cited.
Concurrent interaction of DCs with CD4(+) and CD8(+) T cells improves secondary CTL expansion: It takes three to tango.
Stefanie Hoyer, Sabrina Prommersberger, +4 authors, Niels Schaft.
Eur J Immunol, 2014 Sep 12; 44(12). PMID: 25211552
XCR1+ dendritic cells promote memory CD8+ T cell recall upon secondary infections with Listeria monocytogenes or certain viruses.
Yannick O Alexandre, Sonia Ghilas, +3 authors, Marc Dalod.
J Exp Med, 2015 Dec 24; 213(1). PMID: 26694969    Free PMC article.
Phase I dendritic cell p53 peptide vaccine for head and neck cancer.
Patrick J Schuler, Malgorzata Harasymczuk, +8 authors, Robert L Ferris.
Clin Cancer Res, 2014 Mar 04; 20(9). PMID: 24583792    Free PMC article.
Cancer immunotherapy via dendritic cells.
Karolina Palucka, Jacques Banchereau.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437871    Free PMC article.
Highly Cited. Review.
Immediate Dysfunction of Vaccine-Elicited CD8+ T Cells Primed in the Absence of CD4+ T Cells.
Nicholas M Provine, Rafael A Larocca, +10 authors, Dan H Barouch.
J Immunol, 2016 Jul 28; 197(5). PMID: 27448585    Free PMC article.
Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression.
Hong-bin Ji, Gongxian Liao, +5 authors, Cox Terhorst.
J Immunol, 2004 May 07; 172(10). PMID: 15128759
The ontogenetic path of human dendritic cells.
Lukas Amon, Christian H K Lehmann, +2 authors, Diana Dudziak.
Mol Immunol, 2020 Mar 03; 120. PMID: 32114182
Review.
How are T(H)2-type immune responses initiated and amplified?
William E Paul, Jinfang Zhu.
Nat Rev Immunol, 2010 Mar 26; 10(4). PMID: 20336151    Free PMC article.
Highly Cited. Review.
Stimulation of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) induces inflammatory activation of microglia in culture.
Heehong Hwang, Shinrye Lee, +2 authors, Kyoungho Suk.
J Neurosci Res, 2010 Feb 18; 88(10). PMID: 20162721
Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses.
Spencer C Liang, Yvette E Latchman, +4 authors, Arlene H Sharpe.
Eur J Immunol, 2003 Sep 30; 33(10). PMID: 14515254
Highly Cited.
Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin.
Jason C O'Connor, Caroline André, +6 authors, Robert Dantzer.
J Neurosci, 2009 Apr 03; 29(13). PMID: 19339614    Free PMC article.
Highly Cited.
Differential expression of pathogen-recognition molecules between dendritic cell subsets revealed by plasma membrane proteomic analysis.
Elodie Segura, Eugene Kapp, +6 authors, José A Villadangos.
Mol Immunol, 2010 Mar 30; 47(9). PMID: 20347150
Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer.
Yoshitaro Shindo, Shoichi Hazama, +11 authors, Masaaki Oka.
J Transl Med, 2014 Jun 21; 12. PMID: 24947606    Free PMC article.
Dendritic cells in cancer immunotherapy.
Gerold Schuler.
Eur J Immunol, 2010 Sep 21; 40(8). PMID: 20853498
CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy.
L Diehl, A T den Boer, +5 authors, R E Toes.
Nat Med, 1999 Jul 08; 5(7). PMID: 10395322
Highly Cited.
Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele.
Matija Hedl, Amit Lahiri, +2 authors, Clara Abraham.
Immunity, 2014 May 20; 40(5). PMID: 24837102    Free PMC article.
Dendritic cells: a critical player in cancer therapy?
Anna Karolina Palucka, Hideki Ueno, Joseph Fay, Jacques Banchereau.
J Immunother, 2008 Oct 04; 31(9). PMID: 18833008    Free PMC article.
Review.
CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities.
Tomasz Ahrends, Julia Busselaar, +6 authors, Jannie Borst.
Nat Commun, 2019 Dec 05; 10(1). PMID: 31797935    Free PMC article.
Targeting T cell metabolism for therapy.
David O'Sullivan, Erika L Pearce.
Trends Immunol, 2015 Jan 21; 36(2). PMID: 25601541    Free PMC article.
Highly Cited. Review.
CD154 and IL-2 signaling of CD4+ T cells play a critical role in multiple phases of CD8+ CTL responses following adenovirus vaccination.
Channakeshava Sokke Umeshappa, Roopa Hebbandi Nanjundappa, +4 authors, Jim Xiang.
PLoS One, 2012 Oct 17; 7(10). PMID: 23071696    Free PMC article.
Cell type-specific involvement of RIG-I in antiviral response.
Hiroki Kato, Shintaro Sato, +8 authors, Shizuo Akira.
Immunity, 2005 Jul 26; 23(1). PMID: 16039576
Highly Cited.
Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+T cell recognition.
Kirsteen M Tullett, Ingrid M Leal Rojas, +8 authors, Kristen J Radford.
JCI Insight, 2016 Oct 05; 1(7). PMID: 27699265    Free PMC article.
TLR agonists stimulate Nlrp3-dependent IL-1β production independently of the purinergic P2X7 receptor in dendritic cells and in vivo.
Yuan He, Luigi Franchi, Gabriel Núñez.
J Immunol, 2012 Dec 12; 190(1). PMID: 23225887    Free PMC article.
Targeting of cancer neoantigens with donor-derived T cell receptor repertoires.
Erlend Strønen, Mireille Toebes, +8 authors, Ton N Schumacher.
Science, 2016 May 21; 352(6291). PMID: 27198675
Highly Cited.
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.
Y Agata, A Kawasaki, +4 authors, T Honjo.
Int Immunol, 1996 May 01; 8(5). PMID: 8671665
Highly Cited.
BTLA-Expressing Dendritic Cells in Patients With Tuberculosis Exhibit Reduced Production of IL-12/IFN-α and Increased Production of IL-4 and TGF-β, Favoring Th2 and Foxp3+ Treg Polarization.
Jun-Ai Zhang, Yuan-Bin Lu, +13 authors, Jun-Fa Xu.
Front Immunol, 2020 Apr 17; 11. PMID: 32296431    Free PMC article.
Differential antigen processing by dendritic cell subsets in vivo.
Diana Dudziak, Alice O Kamphorst, +9 authors, Michel C Nussenzweig.
Science, 2007 Jan 06; 315(5808). PMID: 17204652
Highly Cited.
Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia.
Gemma G Kenter, Marij J P Welters, +12 authors, Cornelis J M Melief.
N Engl J Med, 2009 Nov 06; 361(19). PMID: 19890126
Highly Cited.
Molecular mechanisms of T cell co-stimulation and co-inhibition.
Lieping Chen, Dallas B Flies.
Nat Rev Immunol, 2013 Mar 09; 13(4). PMID: 23470321    Free PMC article.
Highly Cited. Review.
IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer.
Margaux Hubert, Elisa Gobbini, +14 authors, Jenny Valladeau-Guilemond.
Sci Immunol, 2020 Apr 19; 5(46). PMID: 32303573
Differential regulation of human blood dendritic cell subsets by IFNs.
T Ito, R Amakawa, +3 authors, S Fukuhara.
J Immunol, 2001 Feb 24; 166(5). PMID: 11207245
Cytokines regulate the capacity of CD8alpha(+) and CD8alpha(-) dendritic cells to prime Th1/Th2 cells in vivo.
R Maldonado-López, C Maliszewski, J Urbain, M Moser.
J Immunol, 2001 Oct 10; 167(8). PMID: 11591758
Dominant expression of the inhibitory FcgammaRIIB prevents antigen presentation by murine plasmacytoid dendritic cells.
Marcella Flores, Dharmesh D Desai, +4 authors, Raphael Clynes.
J Immunol, 2009 Nov 18; 183(11). PMID: 19917701
A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells.
Stephanie Dillon, Anshu Agrawal, +6 authors, Bali Pulendran.
J Immunol, 2004 Apr 07; 172(8). PMID: 15067049
Highly Cited.
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade.
Yoshiko Iwai, Masayoshi Ishida, +3 authors, Nagahiro Minato.
Proc Natl Acad Sci U S A, 2002 Sep 10; 99(19). PMID: 12218188    Free PMC article.
Highly Cited.
Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion.
Mercedes Monteleone, Amanda C Stanley, +11 authors, Kate Schroder.
Cell Rep, 2018 Aug 09; 24(6). PMID: 30089254
Highly Cited.
Pattern recognition receptors and inflammation.
Osamu Takeuchi, Shizuo Akira.
Cell, 2010 Mar 23; 140(6). PMID: 20303872
Highly Cited. Review.
New insights on OX40 in the control of T cell immunity and immune tolerance in vivo.
Xiang Xiao, Weihua Gong, +6 authors, Xian C Li.
J Immunol, 2011 Dec 08; 188(2). PMID: 22147766    Free PMC article.
Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells.
M V Dhodapkar, R M Steinman, +2 authors, N Bhardwaj.
J Exp Med, 2001 Feb 24; 193(2). PMID: 11208863    Free PMC article.
Highly Cited.
Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo.
Nancy Luckashenak, Samira Schroeder, +6 authors, Thomas Brocker.
Immunity, 2008 Apr 05; 28(4). PMID: 18387832
A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
Florian I Schmidt, Alvin Lu, +4 authors, Hidde L Ploegh.
J Exp Med, 2016 Apr 14; 213(5). PMID: 27069117    Free PMC article.
Natural human plasmacytoid dendritic cells induce antigen-specific T-cell responses in melanoma patients.
Jurjen Tel, Erik H J G Aarntzen, +12 authors, I Jolanda M de Vries.
Cancer Res, 2013 Jan 25; 73(3). PMID: 23345163
Highly Cited.
Contribution of the PD-1 ligands/PD-1 signaling pathway to dendritic cell-mediated CD4+ T cell activation.
Harmjan Kuipers, Femke Muskens, +5 authors, Bart N Lambrecht.
Eur J Immunol, 2006 Aug 19; 36(9). PMID: 16917960
Functional RNA delivery targeted to dendritic cells by synthetic nanoparticles.
Kenneth C McCullough, Isabelle Bassi, +2 authors, Nicolas Ruggli.
Ther Deliv, 2012 Oct 06; 3(9). PMID: 23035593
Review.
Toll-like receptors--taking an evolutionary approach.
François Leulier, Bruno Lemaitre.
Nat Rev Genet, 2008 Jan 30; 9(3). PMID: 18227810
Highly Cited. Review.
OX40 costimulation turns off Foxp3+ Tregs.
Minh Diem Vu, Xiang Xiao, +6 authors, Xian Chang Li.
Blood, 2007 Jun 19; 110(7). PMID: 17575071    Free PMC article.
Highly Cited.
Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice.
Andrew J Murphy, Lynn E Macdonald, +13 authors, George D Yancopoulos.
Proc Natl Acad Sci U S A, 2014 Apr 08; 111(14). PMID: 24706856    Free PMC article.
Highly Cited.
An immunogenic personal neoantigen vaccine for patients with melanoma.
Patrick A Ott, Zhuting Hu, +37 authors, Catherine J Wu.
Nature, 2017 Jul 06; 547(7662). PMID: 28678778    Free PMC article.
Highly Cited.
B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.
S Y Tseng, M Otsuji, +7 authors, H Tsuchiya.
J Exp Med, 2001 Apr 03; 193(7). PMID: 11283156    Free PMC article.
Highly Cited.
Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice.
Bei Wang, Neeha Zaidi, +4 authors, Ralph M Steinman.
Breast Cancer Res, 2012 Mar 09; 14(2). PMID: 22397502    Free PMC article.
CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha.
C Caux, B Vanbervliet, +7 authors, J Banchereau.
J Exp Med, 1996 Aug 01; 184(2). PMID: 8760823    Free PMC article.
Highly Cited.
Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics.
Simon Zenke, Margriet M Palm, +10 authors, Jan C Rohr.
Immunity, 2020 Feb 13; 52(2). PMID: 32049052
IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses.
Andreas Schlitzer, Naomi McGovern, +26 authors, Florent Ginhoux.
Immunity, 2013 May 28; 38(5). PMID: 23706669    Free PMC article.
Highly Cited.
Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing.
Mahesh Yadav, Suchit Jhunjhunwala, +11 authors, Lélia Delamarre.
Nature, 2014 Nov 28; 515(7528). PMID: 25428506
Highly Cited.
Mobilization of dendritic cell precursors in patients with cancer by flt3 ligand allows the generation of higher yields of cultured dendritic cells.
Carlos E Marroquin, Jennifer A Westwood, +5 authors, Patrick Hwu.
J Immunother, 2002 May 10; 25(3). PMID: 12000870    Free PMC article.
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.
E Lien, T J Sellati, +8 authors, D T Golenbock.
J Biol Chem, 1999 Nov 24; 274(47). PMID: 10559223
Highly Cited.
Neutralizing tumor-promoting chronic inflammation: a magic bullet?
Lisa M Coussens, Laurence Zitvogel, A Karolina Palucka.
Science, 2013 Jan 19; 339(6117). PMID: 23329041    Free PMC article.
Highly Cited. Review.
TLR11 activation of dendritic cells by a protozoan profilin-like protein.
Felix Yarovinsky, Dekai Zhang, +8 authors, Alan Sher.
Science, 2005 Apr 30; 308(5728). PMID: 15860593
Highly Cited.
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.
Dung T Le, Jennifer N Uram, +32 authors, Luis A Diaz.
N Engl J Med, 2015 Jun 02; 372(26). PMID: 26028255    Free PMC article.
Highly Cited.
Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells.
Andrew Jones, Jessica Bourque, +4 authors, Daniel Hawiger.
Immunity, 2016 Oct 30; 45(5). PMID: 27793593    Free PMC article.
Assembly and localization of Toll-like receptor signalling complexes.
Nicholas J Gay, Martyn F Symmons, Monique Gangloff, Clare E Bryant.
Nat Rev Immunol, 2014 Jul 26; 14(8). PMID: 25060580
Highly Cited. Review.
The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice.
Fang Ma, Jianhua Zhang, Jian Zhang, Cai Zhang.
Cell Mol Immunol, 2010 Jun 15; 7(5). PMID: 20543857    Free PMC article.
CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells.
Sayuri Yamazaki, Diana Dudziak, +5 authors, Ralph M Steinman.
J Immunol, 2008 Nov 05; 181(10). PMID: 18981112    Free PMC article.
Highly Cited.
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.
Florian Heil, Hiroaki Hemmi, +6 authors, Stefan Bauer.
Science, 2004 Feb 21; 303(5663). PMID: 14976262
Highly Cited.
LGP2 binds to PACT to regulate RIG-I- and MDA5-mediated antiviral responses.
Raul Y Sanchez David, Chantal Combredet, +10 authors, Anastassia V Komarova.
Sci Signal, 2019 Oct 03; 12(601). PMID: 31575732
Combined TLR/CD40 stimulation mediates potent cellular immunity by regulating dendritic cell expression of CD70 in vivo.
Phillip J Sanchez, Jennifer A McWilliams, +2 authors, Ross M Kedl.
J Immunol, 2007 Jan 24; 178(3). PMID: 17237405
Regulation of lung injury and repair by Toll-like receptors and hyaluronan.
Dianhua Jiang, Jiurong Liang, +13 authors, Paul W Noble.
Nat Med, 2005 Oct 26; 11(11). PMID: 16244651
Highly Cited.
Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity.
Paul J Tacken, Ingrid S Zeelenberg, +5 authors, Carl G Figdor.
Blood, 2011 Oct 05; 118(26). PMID: 21967977
Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma.
Edward W Roberts, Miranda L Broz, +7 authors, Matthew F Krummel.
Cancer Cell, 2016 Jul 19; 30(2). PMID: 27424807    Free PMC article.
Highly Cited.
Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses.
Roxane Tussiwand, Bart Everts, +9 authors, Kenneth M Murphy.
Immunity, 2015 May 21; 42(5). PMID: 25992862    Free PMC article.
Highly Cited.
A phase I trial of tumor lysate-pulsed dendritic cells in the treatment of advanced cancer.
Alfred E Chang, Bruce G Redman, +5 authors, James J Mulé.
Clin Cancer Res, 2002 Apr 12; 8(4). PMID: 11948109
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.
Liufu Deng, Hua Liang, +12 authors, Ralph R Weichselbaum.
Immunity, 2014 Dec 18; 41(5). PMID: 25517616    Free PMC article.
Highly Cited.
A prophylactic hepatitis B vaccine with a novel adjuvant system.
S Thoelen, N De Clercq, N Tornieporth.
Vaccine, 2001 Mar 21; 19(17-19). PMID: 11257368
Review.
Cutting edge: identification of the thymic stromal lymphopoietin-responsive dendritic cell subset critical for initiation of type 2 contact hypersensitivity.
Masayuki Kitajima, Steven F Ziegler.
J Immunol, 2013 Oct 15; 191(10). PMID: 24123684    Free PMC article.
Chemical Tools for Studying TLR Signaling Dynamics.
Timo Oosenbrug, Michel J van de Graaff, Maaike E Ressing, Sander I van Kasteren.
Cell Chem Biol, 2017 Jun 27; 24(7). PMID: 28648377
Review.
Fcgamma receptors as regulators of immune responses.
Falk Nimmerjahn, Jeffrey V Ravetch.
Nat Rev Immunol, 2007 Dec 08; 8(1). PMID: 18064051
Highly Cited. Review.
Dendritic cell subsets in T cell programming: location dictates function.
S C Eisenbarth.
Nat Rev Immunol, 2018 Nov 23; 19(2). PMID: 30464294    Free PMC article.
Highly Cited. Review.
Cutting edge: ligation of the glucocorticoid-induced TNF receptor enhances autoreactive CD4+ T cell activation and experimental autoimmune encephalomyelitis.
Adam P Kohm, Julie S Williams, Stephen D Miller.
J Immunol, 2004 Apr 07; 172(8). PMID: 15067043
Cytotoxic T lymphocytes specific for I region determinants do not require interactions with H-2K or D gene products.
P Billings, S Burakoff, M E Dorf, B Benacerraf.
J Exp Med, 1977 May 01; 145(5). PMID: 67179    Free PMC article.
The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer.
Tuo Li, Zhijian J Chen.
J Exp Med, 2018 Apr 07; 215(5). PMID: 29622565    Free PMC article.
Highly Cited. Review.
Late developmental plasticity in the T helper 17 lineage.
Yun Kyung Lee, Henrietta Turner, +4 authors, Casey T Weaver.
Immunity, 2009 Jan 03; 30(1). PMID: 19119024    Free PMC article.
Highly Cited.
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow.
M B Lutz, N Kukutsch, +4 authors, G Schuler.
J Immunol Methods, 1999 Feb 26; 223(1). PMID: 10037236
Highly Cited.
Antigen delivery to CD11c+CD8- dendritic cells induces protective immune responses against experimental melanoma in mice in vivo.
Kirsten Neubert, Christian H K Lehmann, +10 authors, Diana Dudziak.
J Immunol, 2014 May 16; 192(12). PMID: 24829411
Dendritic cell-induced memory T cell activation in nonlymphoid tissues.
Linda M Wakim, Jason Waithman, +2 authors, Francis R Carbone.
Science, 2008 Jan 12; 319(5860). PMID: 18187654
Highly Cited.
Toll-like receptor signaling pathways.
Takumi Kawasaki, Taro Kawai.
Front Immunol, 2014 Oct 14; 5. PMID: 25309543    Free PMC article.
Highly Cited. Review.
Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation.
Julie M Curtsinger, Javier O Valenzuela, +2 authors, Matthew F Mescher.
J Immunol, 2005 Apr 09; 174(8). PMID: 15814665
Highly Cited.
Discrimination of bacterial lipoproteins by Toll-like receptor 6.
O Takeuchi, T Kawai, +5 authors, S Akira.
Int Immunol, 2001 Jun 30; 13(7). PMID: 11431423
Highly Cited.
Efficient generation of a monoclonal antibody against the human C-type lectin receptor DCIR by targeting murine dendritic cells.
Gordon F Heidkamp, Kirsten Neubert, +3 authors, Diana Dudziak.
Immunol Lett, 2010 Jun 23; 132(1-2). PMID: 20566350    Free PMC article.
Tumor rejection induced by CD70-mediated quantitative and qualitative effects on effector CD8+ T cell formation.
Ramon Arens, Koen Schepers, +4 authors, Marinus H J van Oers.
J Exp Med, 2004 Jun 09; 199(11). PMID: 15184507    Free PMC article.
Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells.
Timothy N J Bullock, Hideo Yagita.
J Immunol, 2005 Jan 07; 174(2). PMID: 15634890
CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion.
Lukas Heger, Silke Balk, +10 authors, Diana Dudziak.
Front Immunol, 2018 May 15; 9. PMID: 29755453    Free PMC article.
Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination.
Celine Boutros, Ahmad Tarhini, +14 authors, Caroline Robert.
Nat Rev Clin Oncol, 2016 May 05; 13(8). PMID: 27141885
Highly Cited. Review.
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Li Wang, Isabelle Le Mercier, +7 authors, Randolph J Noelle.
Proc Natl Acad Sci U S A, 2014 Oct 01; 111(41). PMID: 25267631    Free PMC article.
A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory.
Christine Bourgeois, Benedita Rocha, Corinne Tanchot.
Science, 2002 Sep 21; 297(5589). PMID: 12242444
Highly Cited.
Design of amidobenzimidazole STING receptor agonists with systemic activity.
Joshi M Ramanjulu, G Scott Pesiridis, +42 authors, John Bertin.
Nature, 2018 Nov 09; 564(7736). PMID: 30405246
Highly Cited.
Signaling by Antibodies: Recent Progress.
Stylianos Bournazos, Taia T Wang, +2 authors, Jeffrey V Ravetch.
Annu Rev Immunol, 2017 Apr 28; 35. PMID: 28446061    Free PMC article.
Highly Cited. Review.
Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.
Christian A Luber, Jürgen Cox, +8 authors, Matthias Mann.
Immunity, 2010 Feb 23; 32(2). PMID: 20171123
Highly Cited.
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors.
Alexandra-Chloé Villani, Rahul Satija, +21 authors, Nir Hacohen.
Science, 2017 Apr 22; 356(6335). PMID: 28428369    Free PMC article.
Highly Cited.
Control of adaptive immunity by the innate immune system.
Akiko Iwasaki, Ruslan Medzhitov.
Nat Immunol, 2015 Mar 20; 16(4). PMID: 25789684    Free PMC article.
Highly Cited. Review.
The Toll-like receptor 1/2 agonists Pam(3) CSK(4) and human β-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes.
Nicholas T Funderburg, Julie K Jadlowsky, +3 authors, Scott F Sieg.
Immunology, 2011 Sep 08; 134(2). PMID: 21896010    Free PMC article.
Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4.
S T Smiley, J A King, W W Hancock.
J Immunol, 2001 Aug 18; 167(5). PMID: 11509636
Highly Cited.
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.
Elie J Diner, Dara L Burdette, +6 authors, Russell E Vance.
Cell Rep, 2013 May 28; 3(5). PMID: 23707065    Free PMC article.
Highly Cited.
Phase I clinical trial of a novel autologous modified-DC vaccine in patients with resected NSCLC.
Chunlei Ge, Ruilei Li, +14 authors, Xin Song.
BMC Cancer, 2017 Dec 23; 17(1). PMID: 29268708    Free PMC article.
Targeting nanoparticles to CD40, DEC-205 or CD11c molecules on dendritic cells for efficient CD8(+) T cell response: a comparative study.
Luis J Cruz, Rodney A Rosalia, +3 authors, Ferry Ossendorp.
J Control Release, 2014 Jul 30; 192. PMID: 25068703
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
François Ghiringhelli, Lionel Apetoh, +23 authors, Laurence Zitvogel.
Nat Med, 2009 Sep 22; 15(10). PMID: 19767732
Highly Cited.
Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny.
Martin Guilliams, Florent Ginhoux, +6 authors, Simon Yona.
Nat Rev Immunol, 2014 Jul 19; 14(8). PMID: 25033907    Free PMC article.
Highly Cited. Review.
Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.
Michael J White, Kate McArthur, +9 authors, Benjamin T Kile.
Cell, 2014 Dec 20; 159(7). PMID: 25525874    Free PMC article.
Highly Cited.
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L Topalian, F Stephen Hodi, +27 authors, Mario Sznol.
N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658127    Free PMC article.
Highly Cited.
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells.
Thomas Korn, Meike Mitsdoerffer, +9 authors, Mohamed Oukka.
Proc Natl Acad Sci U S A, 2008 Nov 19; 105(47). PMID: 19015529    Free PMC article.
Highly Cited.
NF-κB activation triggers NK-cell stimulation by monocyte-derived dendritic cells.
Naomi C Bosch, Reinhard E Voll, +5 authors, Jan Dörrie.
Ther Adv Med Oncol, 2019 Dec 20; 11. PMID: 31853267    Free PMC article.
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.
Liang Zhou, Ivaylo I Ivanov, +6 authors, Dan R Littman.
Nat Immunol, 2007 Jun 22; 8(9). PMID: 17581537
Highly Cited.
Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours.
Jinhua Piao, Yosuke Kamimura, +8 authors, Miyuki Azuma.
Immunology, 2009 Jul 17; 127(4). PMID: 19604302    Free PMC article.
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.
D M Underhill, A Ozinsky, +4 authors, A Aderem.
Nature, 1999 Nov 05; 401(6755). PMID: 10548109
Highly Cited.
Quiescence of Memory CD8(+) T Cells Is Mediated by Regulatory T Cells through Inhibitory Receptor CTLA-4.
Vandana Kalia, Laura Anne Penny, +2 authors, Surojit Sarkar.
Immunity, 2015 Jun 18; 42(6). PMID: 26084026
Dendritic cells in cancer immunotherapy.
Camille M Le Gall, Jorieke Weiden, Loek J Eggermont, Carl G Figdor.
Nat Mater, 2018 May 26; 17(6). PMID: 29795222
ICOS Co-Stimulation: Friend or Foe?
Daniel J Wikenheiser, Jason S Stumhofer.
Front Immunol, 2016 Aug 26; 7. PMID: 27559335    Free PMC article.
Highly Cited. Review.
Maturation of dendritic cells is a prerequisite for inducing immune responses in advanced melanoma patients.
I Jolanda M de Vries, W Joost Lesterhuis, +9 authors, Cornelis J A Punt.
Clin Cancer Res, 2003 Nov 14; 9(14). PMID: 14613986
Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection.
Tobias M Hohl, Amariliz Rivera, +4 authors, Eric G Pamer.
Cell Host Microbe, 2009 Nov 18; 6(5). PMID: 19917501    Free PMC article.
Highly Cited.
STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice.
Zili Wang, Esteban Celis.
Cancer Immunol Immunother, 2015 May 20; 64(8). PMID: 25986168    Free PMC article.
CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.
Johan Verhagen, Raphaël Genolet, +5 authors, David C Wraith.
Proc Natl Acad Sci U S A, 2012 Dec 26; 110(3). PMID: 23267099    Free PMC article.
CTLA-4 can function as a negative regulator of T cell activation.
T L Walunas, D J Lenschow, +5 authors, J A Bluestone.
Immunity, 1994 Aug 01; 1(5). PMID: 7882171
Highly Cited.
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells.
Giorgio Napolitani, Andrea Rinaldi, +2 authors, Antonio Lanzavecchia.
Nat Immunol, 2005 Jul 05; 6(8). PMID: 15995707    Free PMC article.
Highly Cited.
Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells.
Scott Barbuto, Juliana Idoyaga, +4 authors, Tom W Muir.
Nat Chem Biol, 2013 Feb 19; 9(4). PMID: 23416331    Free PMC article.
Autologous Dendritic Cells Pulsed with Allogeneic Tumor Cell Lysate in Mesothelioma: From Mouse to Human.
Joachim G J V Aerts, Pauline L de Goeje, +13 authors, Henk C Hoogsteden.
Clin Cancer Res, 2017 Dec 14; 24(4). PMID: 29233904
CD205 (DEC-205): a recognition receptor for apoptotic and necrotic self.
Rachel E Shrimpton, Matt Butler, +3 authors, Mary A Ritter.
Mol Immunol, 2009 Jan 13; 46(6). PMID: 19135256    Free PMC article.
Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells.
Jens Dannull, Zhen Su, +8 authors, Johannes Vieweg.
J Clin Invest, 2005 Nov 26; 115(12). PMID: 16308572    Free PMC article.
Highly Cited.
Humanization of Antibodies using a Statistical Inference Approach.
Alejandro Clavero-Álvarez, Tomas Di Mambro, +2 authors, Pierpaolo Bruscolini.
Sci Rep, 2018 Oct 06; 8(1). PMID: 30287940    Free PMC article.
Dendritic cell-based immunotherapy.
Rachel L Sabado, Sreekumar Balan, Nina Bhardwaj.
Cell Res, 2016 Dec 28; 27(1). PMID: 28025976    Free PMC article.
Highly Cited. Review.
Targeting OX40 and OX40L for the treatment of autoimmunity and cancer.
William L Redmond, Andrew D Weinberg.
Crit Rev Immunol, 2008 Jan 17; 27(5). PMID: 18197805
Review.
Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody.
G Kraal, M Breel, M Janse, G Bruin.
J Exp Med, 1986 Apr 01; 163(4). PMID: 3950549    Free PMC article.
Highly Cited.
Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation.
Luigi Franchi, Tatjana Eigenbrod, Gabriel Núñez.
J Immunol, 2009 Jun 23; 183(2). PMID: 19542372    Free PMC article.
Highly Cited.
Toll-like receptor agonists: are they good adjuvants?
Sacha Gnjatic, Nikhil B Sawhney, Nina Bhardwaj.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693851    Free PMC article.
Review.
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
G J Freeman, A J Long, +16 authors, T Honjo.
J Exp Med, 2000 Oct 04; 192(7). PMID: 11015443    Free PMC article.
Highly Cited.
Inflammation-driven carcinogenesis is mediated through STING.
Jeonghyun Ahn, Tianli Xia, +3 authors, Glen N Barber.
Nat Commun, 2014 Oct 11; 5. PMID: 25300616    Free PMC article.
Highly Cited.
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.
Cheng-Ming Sun, Jason A Hall, +4 authors, Yasmine Belkaid.
J Exp Med, 2007 Jul 11; 204(8). PMID: 17620362    Free PMC article.
Highly Cited.
Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis.
Na Li, Wenwen Xu, +11 authors, Li Wang.
Sci Rep, 2017 May 05; 7(1). PMID: 28469254    Free PMC article.
Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine.
J Banchereau, A K Palucka, +10 authors, J Fay.
Cancer Res, 2001 Aug 28; 61(17). PMID: 11522640
Highly Cited.
TLR10 Senses HIV-1 Proteins and Significantly Enhances HIV-1 Infection.
Bethany M Henrick, Xiao-Dan Yao, +3 authors, Kenneth L Rosenthal.
Front Immunol, 2019 Apr 02; 10. PMID: 30930906    Free PMC article.
Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer.
Maria Paula Roberti, Satoru Yonekura, +43 authors, Laurence Zitvogel.
Nat Med, 2020 May 27; 26(6). PMID: 32451498
Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells.
M V Dhodapkar, R M Steinman, +8 authors, N Bhardwaj.
J Clin Invest, 1999 Jul 20; 104(2). PMID: 10411546    Free PMC article.
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell.
J P Ridge, F Di Rosa, P Matzinger.
Nature, 1998 Jun 12; 393(6684). PMID: 9624003
Highly Cited.
Ox40 costimulation enhances the development of T cell responses induced by dendritic cells in vivo.
Thibaut De Smedt, Jeffrey Smith, +3 authors, Charles Maliszewski.
J Immunol, 2002 Jan 05; 168(2). PMID: 11777959
Toward targeting inflammasomes: insights into their regulation and activation.
Shelbi Christgen, David E Place, Thirumala-Devi Kanneganti.
Cell Res, 2020 Mar 11; 30(4). PMID: 32152420    Free PMC article.
Review.
Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy.
Xiaozhou Fan, Sergio A Quezada, +2 authors, James P Allison.
J Exp Med, 2014 Apr 02; 211(4). PMID: 24687957    Free PMC article.
Highly Cited.
Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation.
Rachael Kenworthy, Diana Lambert, +7 authors, Hengli Tang.
Nucleic Acids Res, 2009 Sep 05; 37(19). PMID: 19729514    Free PMC article.
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells.
Mercedes B Fuertes, Aalok K Kacha, +4 authors, Thomas F Gajewski.
J Exp Med, 2011 Sep 21; 208(10). PMID: 21930765    Free PMC article.
Highly Cited.
Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation.
Ruth R French, Vadim Y Taraban, +6 authors, Martin J Glennie.
Blood, 2007 Feb 22; 109(11). PMID: 17311995
STING agonists activate latently infected cells and enhance SIV-specific responses ex vivo in naturally SIV controlled cynomolgus macaques.
Takuya Yamamoto, Tomohiro Kanuma, +5 authors, Yasuhiro Yasutomi.
Sci Rep, 2019 Apr 13; 9(1). PMID: 30976083    Free PMC article.
Necrosis: C-type lectins sense cell death.
Alessandra Cambi, Carl Figdor.
Curr Biol, 2009 May 15; 19(9). PMID: 19439262
Review.
Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance.
Laurence Zitvogel, Lorenzo Galluzzi, Mark J Smyth, Guido Kroemer.
Immunity, 2013 Jul 31; 39(1). PMID: 23890065
Highly Cited. Review.
Precision cancer immunotherapy: optimizing dendritic cell-based strategies to induce tumor antigen-specific T-cell responses against individual patient tumors.
Takuya Osada, Koji Nagaoka, +8 authors, H Kim Lyerly.
J Immunother, 2015 Apr 04; 38(4). PMID: 25839441
Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity.
Jakob Loschko, Sylvia Heink, +4 authors, Anne B Krug.
J Immunol, 2011 Nov 15; 187(12). PMID: 22079988
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
Vijay A K Rathinam, Sivapriya Kailasan Vanaja, +5 authors, Katherine A Fitzgerald.
Cell, 2012 Jul 24; 150(3). PMID: 22819539    Free PMC article.
Highly Cited.
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer.
Ugur Sahin, Evelyna Derhovanessian, +47 authors, Özlem Türeci.
Nature, 2017 Jul 06; 547(7662). PMID: 28678784
Highly Cited.
Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand.
K Murata, N Ishii, +5 authors, K Sugamura.
J Exp Med, 2000 Jan 19; 191(2). PMID: 10637280    Free PMC article.
A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo.
Helena Soares, HaeNa Waechter, +6 authors, Ralph M Steinman.
J Exp Med, 2007 Apr 18; 204(5). PMID: 17438065    Free PMC article.
Highly Cited.
Protective humoral immunity elicited by a needle-free malaria vaccine comprised of a chimeric Plasmodium falciparum circumsporozoite protein and a Toll-like receptor 5 agonist, flagellin.
Daniel Carapau, Robert Mitchell, +4 authors, Elizabeth Nardin.
Infect Immun, 2013 Sep 18; 81(12). PMID: 24042110    Free PMC article.
Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells.
Lionel Franz Poulin, Mariolina Salio, +14 authors, Caetano Reis e Sousa.
J Exp Med, 2010 May 19; 207(6). PMID: 20479117    Free PMC article.
Highly Cited.
Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy.
Yuk Yuen Lan, Diana Londoño, +2 authors, Nir Hacohen.
Cell Rep, 2014 Oct 07; 9(1). PMID: 25284779    Free PMC article.
Highly Cited.
Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation.
Joao G Magalhaes, Stephen J Rubino, +17 authors, Dana J Philpott.
Proc Natl Acad Sci U S A, 2011 Aug 23; 108(36). PMID: 21856952    Free PMC article.
CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor alpha: II. Functional analysis.
C Caux, C Massacrier, +5 authors, J Banchereau.
Blood, 1997 Aug 15; 90(4). PMID: 9269763
VISTA is an immune checkpoint molecule for human T cells.
J Louise Lines, Eirini Pantazi, +8 authors, Randolph Noelle.
Cancer Res, 2014 Apr 03; 74(7). PMID: 24691993    Free PMC article.
Highly Cited.
DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity.
Anetta Härtlova, Saskia F Erttmann, +10 authors, Nelson O Gekara.
Immunity, 2015 Feb 19; 42(2). PMID: 25692705
Highly Cited.
Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial.
Bradley C Carthon, Jedd D Wolchok, +8 authors, Padmanee Sharma.
Clin Cancer Res, 2010 May 13; 16(10). PMID: 20460488    Free PMC article.
Highly Cited.
Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells.
Ikuo Takeda, Shoji Ine, +5 authors, Naoto Ishii.
J Immunol, 2004 Mar 09; 172(6). PMID: 15004159
Highly Cited.
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth.
Sarah Davidson, Mirjana Efremova, +10 authors, Sarah A Teichmann.
Cell Rep, 2020 May 21; 31(7). PMID: 32433953    Free PMC article.
Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.
Giulia Nizzoli, Jana Krietsch, +16 authors, Jens Geginat.
Blood, 2013 Jun 25; 122(6). PMID: 23794066
Highly Cited.
A Formulated TLR7/8 Agonist is a Flexible, Highly Potent and Effective Adjuvant for Pandemic Influenza Vaccines.
Neal Van Hoeven, Christopher B Fox, +18 authors, Darrick Carter.
Sci Rep, 2017 Apr 22; 7. PMID: 28429728    Free PMC article.
Paradigm Shift in Dendritic Cell-Based Immunotherapy: From in vitro Generated Monocyte-Derived DCs to Naturally Circulating DC Subsets.
Florian Wimmers, Gerty Schreibelt, +2 authors, I Jolanda M De Vries.
Front Immunol, 2014 May 02; 5. PMID: 24782868    Free PMC article.
Review.
Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4.
Loïc Guillot, Viviane Balloy, +3 authors, Mustapha Si-Tahar.
J Immunol, 2002 Jun 11; 168(12). PMID: 12055204
Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?
J W Yewdell, L C Antón, J R Bennink.
J Immunol, 1996 Sep 01; 157(5). PMID: 8757297
Highly Cited. Review.
Generation and functional characterization of human dendritic cells derived from CD34 cells mobilized into peripheral blood: comparison with bone marrow CD34+ cells.
M Ratta, D Rondelli, +7 authors, R M Lemoli.
Br J Haematol, 1998 Jul 23; 101(4). PMID: 9674752
Circulating precursors of human CD1c+ and CD141+ dendritic cells.
Gaëlle Breton, Jaeyop Lee, +8 authors, Michel C Nussenzweig.
J Exp Med, 2015 Feb 18; 212(3). PMID: 25687281    Free PMC article.
Highly Cited.
Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12.
Ciriana Orabona, Elena Tomasello, +8 authors, Ursula Grohmann.
Eur J Immunol, 2005 Oct 06; 35(11). PMID: 16206234
The history of Toll-like receptors - redefining innate immunity.
Luke A J O'Neill, Douglas Golenbock, Andrew G Bowie.
Nat Rev Immunol, 2013 May 18; 13(6). PMID: 23681101
Highly Cited. Review.
Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans.
V Martijn de Jong, Joana R F Abreu, +7 authors, Bart O Roep.
Diabetologia, 2013 Sep 14; 56(12). PMID: 24030068
BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood.
A Dzionek, A Fuchs, +5 authors, J Schmitz.
J Immunol, 2000 Nov 22; 165(11). PMID: 11086035
Highly Cited.
Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines.
Alexander D Edwards, Sandra S Diebold, +5 authors, Caetano Reis e Sousa.
Eur J Immunol, 2003 Apr 03; 33(4). PMID: 12672047
Highly Cited.
Dendritic Cell Vaccination Enhances Immune Responses and Induces Regression of HER2pos DCIS Independent of Route: Results of Randomized Selection Design Trial.
Lea Lowenfeld, Rosemarie Mick, +9 authors, Brian J Czerniecki.
Clin Cancer Res, 2016 Dec 15; 23(12). PMID: 27965306
T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen.
E W Ehrich, B Devaux, +3 authors, Y H Chien.
J Exp Med, 1993 Aug 01; 178(2). PMID: 8393480    Free PMC article.
Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity.
Nicholas S Wilson, Georg M N Behrens, +13 authors, Jose A Villadangos.
Nat Immunol, 2006 Jan 18; 7(2). PMID: 16415871
Highly Cited.
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.
Taro Kawai, Shizuo Akira.
Nat Immunol, 2010 Apr 21; 11(5). PMID: 20404851
Highly Cited. Review.
Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction.
A Nicole Desch, Sophie L Gibbings, +5 authors, Claudia Jakubzick.
Nat Commun, 2014 Aug 20; 5. PMID: 25135627    Free PMC article.
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells.
Masahide Tone, Yukiko Tone, +4 authors, Herman Waldmann.
Proc Natl Acad Sci U S A, 2003 Nov 11; 100(25). PMID: 14608036    Free PMC article.
Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin.
Megan Raetz, Alexey Kibardin, +6 authors, Felix Yarovinsky.
J Immunol, 2013 Oct 01; 191(9). PMID: 24078692    Free PMC article.
A phase I clinical trial of CD1c (BDCA-1)+ dendritic cells pulsed with HLA-A*0201 peptides for immunotherapy of metastatic hormone refractory prostate cancer.
Rebecca L Prue, Frank Vari, +15 authors, Derek N J Hart.
J Immunother, 2015 Feb 07; 38(2). PMID: 25658616
Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates.
Steven B Mizel, Aaron H Graff, +7 authors, Brian Bell.
Clin Vaccine Immunol, 2008 Nov 07; 16(1). PMID: 18987167    Free PMC article.
RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
Jan Rehwinkel, Choon Ping Tan, +8 authors, Caetano Reis e Sousa.
Cell, 2010 Feb 11; 140(3). PMID: 20144762
Highly Cited.
Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen.
Hamida Hammad, Maud Plantinga, +5 authors, Bart N Lambrecht.
J Exp Med, 2010 Sep 08; 207(10). PMID: 20819925    Free PMC article.
Highly Cited.
Enhanced delivery of immunoliposomes to human dendritic cells by targeting the multilectin receptor DEC-205.
Ali Badiee, Nigel Davies, +4 authors, Masato Kato.
Vaccine, 2007 May 22; 25(25). PMID: 17512099
Antigen presenting cell-selective drug delivery by glycan-decorated nanocarriers.
Theresa Frenz, Elena Grabski, +5 authors, Ulrich Kalinke.
Eur J Pharm Biopharm, 2015 Feb 24; 95(Pt A). PMID: 25701806
Review.
Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand.
H W Mages, A Hutloff, +4 authors, R A Kroczek.
Eur J Immunol, 2000 Apr 13; 30(4). PMID: 10760791
Host tissue determinants of tumour immunity.
Hélène Salmon, Romain Remark, Sacha Gnjatic, Miriam Merad.
Nat Rev Cancer, 2019 Mar 15; 19(4). PMID: 30867580    Free PMC article.
Highly Cited. Review.
A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant.
Scott A Halperin, Gary Van Nest, +3 authors, Joseph J Eiden.
Vaccine, 2003 May 15; 21(19-20). PMID: 12744879
The function of Fcγ receptors in dendritic cells and macrophages.
Martin Guilliams, Pierre Bruhns, +2 authors, Bart N Lambrecht.
Nat Rev Immunol, 2014 Jan 22; 14(2). PMID: 24445665
Highly Cited. Review.
Histo-cytometry: a method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes.
Michael Y Gerner, Wolfgang Kastenmuller, +2 authors, Ronald N Germain.
Immunity, 2012 Aug 07; 37(2). PMID: 22863836    Free PMC article.
Highly Cited.
Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming.
Rhys S Allan, Jason Waithman, +7 authors, Francis R Carbone.
Immunity, 2006 Jul 25; 25(1). PMID: 16860764
Highly Cited.
Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens.
Sarah L Jongbloed, Andrew J Kassianos, +10 authors, Kristen J Radford.
J Exp Med, 2010 May 19; 207(6). PMID: 20479116    Free PMC article.
Highly Cited.
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
Xing Liu, Zhibin Zhang, +4 authors, Judy Lieberman.
Nature, 2016 Jul 08; 535(7610). PMID: 27383986    Free PMC article.
Highly Cited.
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
L Alexopoulou, A C Holt, R Medzhitov, R A Flavell.
Nature, 2001 Oct 19; 413(6857). PMID: 11607032
Highly Cited.
Constitutive versus activation-dependent cross-presentation of immune complexes by CD8(+) and CD8(-) dendritic cells in vivo.
Joke M M den Haan, Michael J Bevan.
J Exp Med, 2002 Sep 18; 196(6). PMID: 12235214    Free PMC article.
Highly Cited.
In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas.
C Reis e Sousa, S Hieny, +4 authors, A Sher.
J Exp Med, 1998 Jan 07; 186(11). PMID: 9382881    Free PMC article.
Highly Cited.
Visualization of immediate immune responses to pioneer metastatic cells in the lung.
Mark B Headley, Adriaan Bins, +4 authors, Matthew F Krummel.
Nature, 2016 Mar 17; 531(7595). PMID: 26982733    Free PMC article.
Highly Cited.
Targeting antigen to MHC class II molecules promotes efficient cross-presentation and enhances immunotherapy.
Nina Dickgreber, Patrizia Stoitzner, +9 authors, Ian F Hermans.
J Immunol, 2009 Jan 22; 182(3). PMID: 19155471
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
Li Wang, Rotem Rubinstein, +10 authors, Randolph J Noelle.
J Exp Med, 2011 Mar 09; 208(3). PMID: 21383057    Free PMC article.
Highly Cited.
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy.
Spencer C Wei, Colm R Duffy, James P Allison.
Cancer Discov, 2018 Aug 18; 8(9). PMID: 30115704
Highly Cited. Review.
A Death Notice for In-Vitro-Generated GM-CSF Dendritic Cells?
Martin Guilliams, Bernard Malissen.
Immunity, 2015 Jun 18; 42(6). PMID: 26084019
Injection of IL-12 gene-transduced dendritic cells into mouse liver tumor lesions activates both innate and acquired immunity.
T Tatsumi, T Takehara, +9 authors, N Hayashi.
Gene Ther, 2007 Mar 09; 14(11). PMID: 17344900
Characteristics and Significance of the Pre-metastatic Niche.
Yang Liu, Xuetao Cao.
Cancer Cell, 2016 Nov 16; 30(5). PMID: 27846389
Highly Cited. Review.
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.
F Hayashi, K D Smith, +7 authors, A Aderem.
Nature, 2001 Apr 27; 410(6832). PMID: 11323673
Highly Cited.
Antigen availability determines CD8⁺ T cell-dendritic cell interaction kinetics and memory fate decisions.
Sarah E Henrickson, Mario Perro, +13 authors, Ulrich H von Andrian.
Immunity, 2013 Sep 24; 39(3). PMID: 24054328    Free PMC article.
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4.
P Waterhouse, J M Penninger, +6 authors, T W Mak.
Science, 1995 Nov 10; 270(5238). PMID: 7481803
Highly Cited.
CpG-ODN-induced inflammation is sufficient to cause T-cell-mediated autoaggression against hepatocytes.
Torsten Sacher, Percy Knolle, +3 authors, Andreas Limmer.
Eur J Immunol, 2003 Jan 09; 32(12). PMID: 12516551
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling.
R B Yang, M R Mark, +7 authors, P J Godowski.
Nature, 1998 Sep 29; 395(6699). PMID: 9751057
Highly Cited.
CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo.
J M den Haan, S M Lehar, M J Bevan.
J Exp Med, 2000 Dec 20; 192(12). PMID: 11120766    Free PMC article.
Highly Cited.
F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells.
Susan Ahrens, Santiago Zelenay, +12 authors, Oliver Schulz.
Immunity, 2012 Apr 10; 36(4). PMID: 22483800
Highly Cited.
STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment.
Takayuki Ohkuri, Arundhati Ghosh, +6 authors, Hideho Okada.
Cancer Immunol Res, 2014 Oct 11; 2(12). PMID: 25300859    Free PMC article.
STING: infection, inflammation and cancer.
Glen N Barber.
Nat Rev Immunol, 2015 Nov 26; 15(12). PMID: 26603901    Free PMC article.
Highly Cited. Review.
Targeted delivery of α-galactosylceramide to CD8α+ dendritic cells optimizes type I NKT cell-based antitumor responses.
Elodie Macho-Fernandez, Luis Javier Cruz, +5 authors, Christelle Faveeuw.
J Immunol, 2014 Jun 11; 193(2). PMID: 24913977
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.
Enfu Hui, Jeanne Cheung, +8 authors, Ronald D Vale.
Science, 2017 Mar 11; 355(6332). PMID: 28280247    Free PMC article.
Highly Cited.
A mouse model of Salmonella typhi infection.
Ramkumar Mathur, Hyunju Oh, +5 authors, Sankar Ghosh.
Cell, 2012 Oct 30; 151(3). PMID: 23101627    Free PMC article.
CTLA-4 control over Foxp3+ regulatory T cell function.
Kajsa Wing, Yasushi Onishi, +5 authors, Shimon Sakaguchi.
Science, 2008 Oct 11; 322(5899). PMID: 18845758
Highly Cited.
Viral infection switches non-plasmacytoid dendritic cells into high interferon producers.
Sandra S Diebold, Maria Montoya, +7 authors, Caetano Reis e Sousa.
Nature, 2003 Jun 24; 424(6946). PMID: 12819664
Highly Cited.
ICOS-ligand expression on plasmacytoid dendritic cells supports breast cancer progression by promoting the accumulation of immunosuppressive CD4+ T cells.
Julien Faget, Nathalie Bendriss-Vermare, +11 authors, Christine Ménétrier-Caux.
Cancer Res, 2012 Oct 03; 72(23). PMID: 23026134
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential.
Padmanee Sharma, James P Allison.
Cell, 2015 Apr 11; 161(2). PMID: 25860605    Free PMC article.
Highly Cited. Review.
Clinical blockade of PD1 and LAG3--potential mechanisms of action.
Linh T Nguyen, Pamela S Ohashi.
Nat Rev Immunol, 2014 Dec 24; 15(1). PMID: 25534622
Highly Cited. Review.
In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination.
Laura C Bonifaz, David P Bonnyay, +7 authors, Ralph M Steinman.
J Exp Med, 2004 Mar 17; 199(6). PMID: 15024047    Free PMC article.
Highly Cited.
Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease.
Karl S Lang, Mike Recher, +12 authors, Rolf M Zinkernagel.
Nat Med, 2005 Jan 18; 11(2). PMID: 15654326
Highly Cited.
Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease.
Xuetao Cao.
Nat Rev Immunol, 2015 Dec 30; 16(1). PMID: 26711677
Highly Cited. Review.
An updated view of the intracellular mechanisms regulating cross-presentation.
Priyanka Nair-Gupta, J Magarian Blander.
Front Immunol, 2013 Dec 10; 4. PMID: 24319447    Free PMC article.
Review.
STING, DCs and the link between innate and adaptive tumor immunity.
Ralph E Vatner, Edith M Janssen.
Mol Immunol, 2017 Dec 24; 110. PMID: 29273394    Free PMC article.
Review.
Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation.
Yvette van Kooyk, Wendy W J Unger, +2 authors, Juan J García-Vallejo.
Mol Immunol, 2012 Nov 20; 55(2). PMID: 23158834
Review.
Defining dendritic cells.
Barbara U Schraml, Caetano Reis e Sousa.
Curr Opin Immunol, 2015 Jan 02; 32. PMID: 25553392
Highly Cited. Review.
T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation.
Sarah E Henrickson, Thorsten R Mempel, +10 authors, Ulrich H von Andrian.
Nat Immunol, 2008 Jan 22; 9(3). PMID: 18204450    Free PMC article.
Highly Cited.
Transcriptional Control of Dendritic Cell Development.
Theresa L Murphy, Gary E Grajales-Reyes, +6 authors, Kenneth M Murphy.
Annu Rev Immunol, 2016 Jan 07; 34. PMID: 26735697    Free PMC article.
Highly Cited. Review.
Induction of cytotoxic T lymphocytes against I-region-coded determinants: in vitro evidence for a third histocompatibility locus in the mouse.
H Wagner, D Götze, L Ptschelinzew, M Röllinghoff.
J Exp Med, 1975 Dec 01; 142(6). PMID: 53265    Free PMC article.
Expression of Indoleamine 2,3-Dioxygenase Induced by IFN-γ and TNF-α as Potential Biomarker of Prostate Cancer Progression.
Irina Banzola, Chantal Mengus, +11 authors, Maurizio Provenzano.
Front Immunol, 2018 Jun 14; 9. PMID: 29896191    Free PMC article.
OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.
Sarah Buchan, Teresa Manzo, +12 authors, Ronjon Chakraverty.
J Immunol, 2014 Nov 19; 194(1). PMID: 25404365    Free PMC article.
Characterization of human inducible costimulator ligand expression and function.
A Aicher, M Hayden-Ledbetter, +6 authors, E A Clark.
J Immunol, 2000 Apr 26; 164(9). PMID: 10779774
"Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60.
Kindra M Kelly, Haoyang Zhuang, +9 authors, Westley H Reeves.
Arthritis Rheum, 2006 Apr 29; 54(5). PMID: 16645989
c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response.
Joshua J Woodward, Anthony T Iavarone, Daniel A Portnoy.
Science, 2010 May 29; 328(5986). PMID: 20508090    Free PMC article.
Highly Cited.
CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo.
R Maldonado-López, T De Smedt, +7 authors, M Moser.
J Exp Med, 1999 Feb 02; 189(3). PMID: 9927520    Free PMC article.
Highly Cited.
Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice.
Yang Xiao, Fang Liu, +9 authors, Huimin Yan.
Cell Mol Immunol, 2014 Nov 25; 12(6). PMID: 25418468    Free PMC article.
The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs.
Fabián Salazar, Dennis Awuah, +2 authors, Amir M Ghaemmaghami.
Sci Rep, 2017 Mar 04; 7. PMID: 28256612    Free PMC article.
CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy.
Hong Chen, Tihui Fu, +7 authors, Padmanee Sharma.
Cancer Immunol Res, 2014 Apr 30; 2(2). PMID: 24778280    Free PMC article.
Toll-dependent selection of microbial antigens for presentation by dendritic cells.
J Magarian Blander, Ruslan Medzhitov.
Nature, 2006 Feb 21; 440(7085). PMID: 16489357
Highly Cited.
Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery.
E-Chiang Lee, Qi Liang, +34 authors, Allan Bradley.
Nat Biotechnol, 2014 Mar 19; 32(4). PMID: 24633243
Highly Cited.
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.
Kyoung Wan Yoon, Sanguine Byun, +13 authors, Sam W Lee.
Science, 2015 Aug 01; 349(6247). PMID: 26228159    Free PMC article.
Highly Cited.
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells.
Gang Wei, Lai Wei, +13 authors, Keji Zhao.
Immunity, 2009 Jan 16; 30(1). PMID: 19144320    Free PMC article.
Highly Cited.
Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction.
Flora Castellino, Alex Y Huang, +3 authors, Ronald N Germain.
Nature, 2006 Apr 14; 440(7086). PMID: 16612374
Highly Cited.
Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination.
Hongxia Wang, Xiaofei Yu, +4 authors, Xiang-Yang Wang.
J Immunol, 2013 Nov 13; 191(12). PMID: 24218449    Free PMC article.
Anti-CTLA-4 therapy requires an Fc domain for efficacy.
Jessica R Ingram, Olga S Blomberg, +15 authors, Michael Dougan.
Proc Natl Acad Sci U S A, 2018 Mar 28; 115(15). PMID: 29581255    Free PMC article.
Highly Cited.
Targeting of antigens to activated dendritic cells in vivo cures metastatic melanoma in mice.
Karsten Mahnke, Yingjie Qian, +3 authors, Alexander H Enk.
Cancer Res, 2005 Aug 03; 65(15). PMID: 16061687
Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice.
Payal B Watchmaker, Katharina Lahl, +9 authors, Eugene C Butcher.
Nat Immunol, 2013 Dec 03; 15(1). PMID: 24292363    Free PMC article.
Highly Cited.
The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells.
Shin-ichi Kano, Kojiro Sato, +6 authors, Tadatsugu Taniguchi.
Nat Immunol, 2007 Dec 07; 9(1). PMID: 18059273
Indoleamine 2,3-dioxygenase and dendritic cell tolerogenicity.
Jamie L Harden, Nejat K Egilmez.
Immunol Invest, 2012 Sep 29; 41(6-7). PMID: 23017144    Free PMC article.
Review.
Transforming growth factor-beta induces development of the T(H)17 lineage.
Paul R Mangan, Laurie E Harrington, +7 authors, Casey T Weaver.
Nature, 2006 May 02; 441(7090). PMID: 16648837
Highly Cited.
Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles.
Claire Vanpouille-Box, Jules A Hoffmann, Lorenzo Galluzzi.
Nat Rev Drug Discov, 2019 Sep 27; 18(11). PMID: 31554927
Review.
OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis.
Matthew Karulf, Ann Kelly, Andrew D Weinberg, Jeffrey A Gold.
J Immunol, 2010 Sep 17; 185(8). PMID: 20844189    Free PMC article.
Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance.
Vincent Flacher, Christoph H Tripp, +4 authors, Nikolaus Romani.
EMBO Mol Med, 2014 Aug 03; 6(9). PMID: 25085878    Free PMC article.
Innate Control of Adaptive Immunity: Beyond the Three-Signal Paradigm.
Aakanksha Jain, Chandrashekhar Pasare.
J Immunol, 2017 May 10; 198(10). PMID: 28483987    Free PMC article.
Highly Cited. Review.
FcγR dependent mechanisms of cytotoxic, agonistic, and neutralizing antibody activities.
Falk Nimmerjahn, Sina Gordan, Anja Lux.
Trends Immunol, 2015 May 20; 36(6). PMID: 25981969
Highly Cited. Review.
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4.
R Shimazu, S Akashi, +4 authors, M Kimoto.
J Exp Med, 1999 Jun 08; 189(11). PMID: 10359581    Free PMC article.
Highly Cited.
Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells.
Michael J Eppihimer, Jason Gunn, +4 authors, John P Leonard.
Microcirculation, 2002 Apr 05; 9(2). PMID: 11932780    Free PMC article.
Highly Cited.
Protective CD8 T cell immunity triggered by CpG-protein conjugates competes with the efficacy of live vaccines.
Antje Heit, Frank Schmitz, +4 authors, Katharina M Huster.
J Immunol, 2005 Mar 22; 174(7). PMID: 15778402
Dendritic Cells As Inducers of Peripheral Tolerance.
Courtney A Iberg, Andrew Jones, Daniel Hawiger.
Trends Immunol, 2017 Aug 23; 38(11). PMID: 28826942    Free PMC article.
Highly Cited. Review.
Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions.
H Jonuleit, U Kühn, +5 authors, A H Enk.
Eur J Immunol, 1998 Feb 17; 27(12). PMID: 9464798
Highly Cited.
Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity.
Kai Hildner, Brian T Edelson, +10 authors, Kenneth M Murphy.
Science, 2008 Nov 15; 322(5904). PMID: 19008445    Free PMC article.
Highly Cited.
Rationale for anti-GITR cancer immunotherapy.
Deborah A Knee, Becker Hewes, Jennifer L Brogdon.
Eur J Cancer, 2016 Sep 04; 67. PMID: 27591414
Highly Cited. Review.
Expression of tumor-associated differentiation antigens, MUC1 glycoforms and CEA, in human thymic epithelial cells: implications for self-tolerance and tumor therapy.
Silvie Cloosen, Janna Arnold, +3 authors, Wilfred T V Germeraad.
Cancer Res, 2007 Apr 19; 67(8). PMID: 17440107
Dendritic cells in the thymus contribute to T-regulatory cell induction.
Anna I Proietto, Serani van Dommelen, +9 authors, Li Wu.
Proc Natl Acad Sci U S A, 2008 Dec 17; 105(50). PMID: 19073916    Free PMC article.
Highly Cited.
Properties of mouse and human IgG receptors and their contribution to disease models.
Pierre Bruhns.
Blood, 2012 Apr 27; 119(24). PMID: 22535666
Highly Cited. Review.
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
J C Schwartz, X Zhang, +2 authors, S C Almo.
Nature, 2001 Mar 30; 410(6828). PMID: 11279501
STING and the innate immune response to nucleic acids in the cytosol.
Dara L Burdette, Russell E Vance.
Nat Immunol, 2012 Dec 15; 14(1). PMID: 23238760
Highly Cited. Review.
Development of a dendritic cell (DC)-based vaccine for patients with advanced colorectal cancer.
N Rains, R J Cannan, W Chen, R S Stubbs.
Hepatogastroenterology, 2001 May 31; 48(38). PMID: 11379307
CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites.
Mona Mashayekhi, Michelle M Sandau, +8 authors, Kenneth M Murphy.
Immunity, 2011 Aug 27; 35(2). PMID: 21867928    Free PMC article.
Highly Cited.
CTLA-4: a moving target in immunotherapy.
Behzad Rowshanravan, Neil Halliday, David M Sansom.
Blood, 2017 Nov 10; 131(1). PMID: 29118008    Free PMC article.
Highly Cited. Review.
Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ-resident dendritic cells.
Elodie Segura, Mélanie Durand, Sebastian Amigorena.
J Exp Med, 2013 Apr 10; 210(5). PMID: 23569327    Free PMC article.
Highly Cited.
Differential capability of human cutaneous dendritic cell subsets to initiate Th17 responses.
Alicia R Mathers, Brian M Janelsins, +5 authors, Adriana T Larregina.
J Immunol, 2009 Jan 07; 182(2). PMID: 19124735
High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization.
Marcela Alcántara-Hernández, Rebecca Leylek, +6 authors, Juliana Idoyaga.
Immunity, 2017 Dec 10; 47(6). PMID: 29221729    Free PMC article.
Highly Cited.
Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo.
N C Fernandez, A Lozier, +7 authors, L Zitvogel.
Nat Med, 1999 Apr 15; 5(4). PMID: 10202929
Highly Cited.
ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis.
Craig R Homer, Amy L Richmond, +2 authors, Christine McDonald.
Gastroenterology, 2010 Jul 20; 139(5). PMID: 20637199    Free PMC article.
Highly Cited.
Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer.
Eric Tran, Simon Turcotte, +10 authors, Steven A Rosenberg.
Science, 2014 May 09; 344(6184). PMID: 24812403    Free PMC article.
Highly Cited.
Overcoming T cell exhaustion in infection and cancer.
Kristen E Pauken, E John Wherry.
Trends Immunol, 2015 Mar 24; 36(4). PMID: 25797516    Free PMC article.
Highly Cited. Review.
Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines.
Dieke van Dinther, Dorian A Stolk, +3 authors, Joke M M den Haan.
J Leukoc Biol, 2017 Jul 22; 102(4). PMID: 28729358    Free PMC article.
Review.
Hsp72 induces inflammation and regulates cytokine production in airway epithelium through a TLR4- and NF-kappaB-dependent mechanism.
Margaret A Chase, Derek S Wheeler, +3 authors, Kristen Page.
J Immunol, 2007 Oct 20; 179(9). PMID: 17947709    Free PMC article.
ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection.
Stephen A Redpath, Nienke van der Werf, +4 authors, Matthew D Taylor.
Eur J Immunol, 2013 Jan 16; 43(3). PMID: 23319295    Free PMC article.
Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation.
Lillian Cohn, Bithi Chatterjee, +10 authors, Lélia Delamarre.
J Exp Med, 2013 Apr 10; 210(5). PMID: 23569326    Free PMC article.
Highly Cited.
Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection.
Michael H Askenase, Seong-Ji Han, +10 authors, Yasmine Belkaid.
Immunity, 2015 Jun 14; 42(6). PMID: 26070484    Free PMC article.
Highly Cited.
VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer.
Jianjun Gao, John F Ward, +16 authors, Padmanee Sharma.
Nat Med, 2017 Mar 28; 23(5). PMID: 28346412    Free PMC article.
Highly Cited.
Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response.
Vijay K Gonugunta, Tomomi Sakai, +4 authors, Nan Yan.
Cell Rep, 2017 Dec 16; 21(11). PMID: 29241549    Free PMC article.
A non-redundant role for OX40 in the competitive fitness of Treg in response to IL-2.
Silvia Piconese, Paola Pittoni, +4 authors, Mario P Colombo.
Eur J Immunol, 2010 Sep 02; 40(10). PMID: 20806292
Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses.
Lei Huang, Lingqian Li, +9 authors, Andrew L Mellor.
J Immunol, 2013 Aug 30; 191(7). PMID: 23986532    Free PMC article.
Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration.
P F Mühlradt, M Kiess, +2 authors, G Jung.
J Exp Med, 1997 Jun 02; 185(11). PMID: 9166424    Free PMC article.
Highly Cited.
TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events.
Karen A Cavassani, Makoto Ishii, +5 authors, Steven L Kunkel.
J Exp Med, 2008 Oct 08; 205(11). PMID: 18838547    Free PMC article.
Highly Cited.
TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells.
Tom A Barr, Sheila Brown, +2 authors, David Gray.
Eur J Immunol, 2007 Oct 06; 37(11). PMID: 17918201    Free PMC article.
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A.
Juliana Idoyaga, Ashira Lubkin, +8 authors, Ralph M Steinman.
Proc Natl Acad Sci U S A, 2011 Jan 26; 108(6). PMID: 21262813    Free PMC article.
Highly Cited.
Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.
Ying Xie, Akgül Akpinarli, +6 authors, Paul Andrew Antony.
J Exp Med, 2010 Feb 17; 207(3). PMID: 20156973    Free PMC article.
Highly Cited.
Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells.
Ingeborg Streng-Ouwehand, Nataschja I Ho, +9 authors, Yvette van Kooyk.
Elife, 2016 Mar 22; 5. PMID: 26999763    Free PMC article.
CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help.
Yusuke Nakanishi, Bao Lu, Craig Gerard, Akiko Iwasaki.
Nature, 2009 Nov 10; 462(7272). PMID: 19898495    Free PMC article.
Highly Cited.
Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs.
Alyson Haslam, Vinay Prasad.
JAMA Netw Open, 2019 May 06; 2(5). PMID: 31050774    Free PMC article.
Highly Cited.
Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation.
Ru Liu-Bryan, Peter Scott, +2 authors, Robert Terkeltaub.
Arthritis Rheum, 2005 Sep 06; 52(9). PMID: 16142712
Highly Cited.
Engineered niches support the development of human dendritic cells in humanized mice.
Giorgio Anselmi, Kristine Vaivode, +9 authors, Pierre Guermonprez.
Nat Commun, 2020 Apr 30; 11(1). PMID: 32345968    Free PMC article.
Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2.
R Schwandner, R Dziarski, +2 authors, C J Kirschning.
J Biol Chem, 1999 Jun 11; 274(25). PMID: 10364168
Highly Cited.
Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.
Manish J Butte, Mary E Keir, +2 authors, Gordon J Freeman.
Immunity, 2007 Jul 17; 27(1). PMID: 17629517    Free PMC article.
Highly Cited.
Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.
Miranda L Broz, Mikhail Binnewies, +12 authors, Matthew F Krummel.
Cancer Cell, 2014 Dec 03; 26(5). PMID: 25446897    Free PMC article.
Highly Cited.
Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2.
Arya Biragyn, Pier Adelchi Ruffini, +8 authors, Larry W Kwak.
Science, 2002 Nov 02; 298(5595). PMID: 12411706
Highly Cited.
Diverse roles of STING-dependent signaling on the development of cancer.
J Ahn, H Konno, G N Barber.
Oncogene, 2015 Feb 03; 34(41). PMID: 25639870    Free PMC article.
The Role of Invariant Natural Killer T Cells in Dendritic Cell Licensing, Cross-Priming, and Memory CD8(+) T Cell Generation.
Catherine Gottschalk, Elisabeth Mettke, Christian Kurts.
Front Immunol, 2015 Aug 19; 6. PMID: 26284065    Free PMC article.
Review.
Helping the CD8(+) T-cell response.
Michael J Bevan.
Nat Rev Immunol, 2004 Aug 03; 4(8). PMID: 15286726
Highly Cited. Review.
Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains.
Jonathan A Harton, Michael W Linhoff, Jinghua Zhang, Jenny P-Y Ting.
J Immunol, 2002 Oct 09; 169(8). PMID: 12370334
Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity.
Samuele Calabro, Dong Liu, +11 authors, Stephanie C Eisenbarth.
Cell Rep, 2016 Aug 23; 16(9). PMID: 27545885    Free PMC article.
IFN-beta1b induces kynurenine pathway metabolism in human macrophages: potential implications for multiple sclerosis treatment.
G J Guillemin, S J Kerr, +4 authors, B J Brew.
J Interferon Cytokine Res, 2002 Jan 19; 21(12). PMID: 11798468
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
M F Krummel, J P Allison.
J Exp Med, 1995 Aug 01; 182(2). PMID: 7543139    Free PMC article.
Highly Cited.
Acquisition of CD80 by human T cells at early stages of activation: functional involvement of CD80 acquisition in T cell to T cell interaction.
Zohreh Tatari-Calderone, Roshanak Tolouei Semnani, +2 authors, Helen Sabzevari.
J Immunol, 2002 Nov 22; 169(11). PMID: 12444120
Regulatory T cells in cancer immunosuppression - implications for anticancer therapy.
Yosuke Togashi, Kohei Shitara, Hiroyoshi Nishikawa.
Nat Rev Clin Oncol, 2019 Feb 02; 16(6). PMID: 30705439
Highly Cited. Review.
Proteomics of Human Dendritic Cell Subsets Reveals Subset-Specific Surface Markers and Differential Inflammasome Function.
Kuntal Worah, Till S M Mathan, +14 authors, Sonja I Buschow.
Cell Rep, 2016 Sep 15; 16(11). PMID: 27626665    Free PMC article.
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.
Nicholas McGranahan, Andrew J S Furness, +33 authors, Charles Swanton.
Science, 2016 Mar 05; 351(6280). PMID: 26940869    Free PMC article.
Highly Cited.
Cross-presentation of viral antigens in dribbles leads to efficient activation of virus-specific human memory T cells.
Wei Ye, Yun Xing, +7 authors, Hong-Ming Hu.
J Transl Med, 2014 Apr 17; 12. PMID: 24735498    Free PMC article.
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Seng-Ryong Woo, Mercedes B Fuertes, +9 authors, Thomas F Gajewski.
Immunity, 2014 Dec 18; 41(5). PMID: 25517615    Free PMC article.
Highly Cited.
Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells.
Patrick Fernandes Rodrigues, Llucia Alberti-Servera, +3 authors, Roxane Tussiwand.
Nat Immunol, 2018 Jun 22; 19(7). PMID: 29925996
Highly Cited.
DNA sensing by the cGAS-STING pathway in health and disease.
Mona Motwani, Scott Pesiridis, Katherine A Fitzgerald.
Nat Rev Genet, 2019 Jul 31; 20(11). PMID: 31358977
Highly Cited. Review.
DNA-based immunization by in vivo transfection of dendritic cells.
C Condon, S C Watkins, +2 authors, L D Falo.
Nat Med, 1996 Oct 01; 2(10). PMID: 8837611
Highly Cited.
The interaction properties of costimulatory molecules revisited.
Alison V Collins, Douglas W Brodie, +6 authors, Simon J Davis.
Immunity, 2002 Aug 28; 17(2). PMID: 12196291
Highly Cited.
Transcriptional control of dendritic cell development and functions.
Lukas Amon, Christian H K Lehmann, +3 authors, Diana Dudziak.
Int Rev Cell Mol Biol, 2019 Nov 25; 349. PMID: 31759434
Review.
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Ansuman T Satpathy, Carlos G Briseño, +20 authors, Kenneth M Murphy.
Nat Immunol, 2013 Aug 06; 14(9). PMID: 23913046    Free PMC article.
Highly Cited.
PD-1+ natural killer cells in human non-small cell lung cancer can be activated by PD-1/PD-L1 blockade.
Marcel P Trefny, Monika Kaiser, +7 authors, Alfred Zippelius.
Cancer Immunol Immunother, 2020 Apr 17; 69(8). PMID: 32296919
CD8 alpha+, but not CD8 alpha-, dendritic cells tolerize Th2 responses via contact-dependent and -independent mechanisms, and reverse airway hyperresponsiveness, Th2, and eosinophil responses in a mouse model of asthma.
John R Gordon, Fang Li, +2 authors, Xiaobei Zhang.
J Immunol, 2005 Jul 22; 175(3). PMID: 16034089
Activation of autoreactive B cells by CpG dsDNA.
Gregory A Viglianti, Christina M Lau, +3 authors, Ann Marshak-Rothstein.
Immunity, 2003 Dec 13; 19(6). PMID: 14670301
Highly Cited.
RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection.
Yang Zhao, Xiang Ye, +2 authors, John Karijolich.
Nat Commun, 2018 Nov 20; 9(1). PMID: 30451863    Free PMC article.
Highly Cited.
Targeting dendritic cells with antigen-containing liposomes: a highly effective procedure for induction of antitumor immunity and for tumor immunotherapy.
Christina L van Broekhoven, Christopher R Parish, +2 authors, Joseph G Altin.
Cancer Res, 2004 Jun 19; 64(12). PMID: 15205352
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.
M Cella, D Scheidegger, +3 authors, G Alber.
J Exp Med, 1996 Aug 01; 184(2). PMID: 8760829    Free PMC article.
Highly Cited.
CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function.
Arata Takeuchi, Takashi Saito.
Front Immunol, 2017 Mar 11; 8. PMID: 28280496    Free PMC article.
Highly Cited. Review.
Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity.
Mikhail Binnewies, Adriana M Mujal, +15 authors, Matthew F Krummel.
Cell, 2019 Apr 09; 177(3). PMID: 30955881    Free PMC article.
Highly Cited.
LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways.
Ke Zhao, Juan Du, +8 authors, Xiao-Fang Yu.
J Autoimmun, 2018 Mar 12; 90. PMID: 29525183
Cutting edge: cardiac myosin activates innate immune responses through TLRs.
Ping Zhang, Carol J Cox, Kathy M Alvarez, Madeleine W Cunningham.
J Immunol, 2009 Jun 19; 183(1). PMID: 19535635    Free PMC article.
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.
A Hutloff, A M Dittrich, +4 authors, R A Kroczek.
Nature, 1999 Feb 04; 397(6716). PMID: 9930702
Highly Cited.
Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro.
R M Steinman, Z A Cohn.
J Exp Med, 1974 Feb 01; 139(2). PMID: 4589990    Free PMC article.
Highly Cited.
Agonistic CD40 antibodies and cancer therapy.
Robert H Vonderheide, Martin J Glennie.
Clin Cancer Res, 2013 Mar 06; 19(5). PMID: 23460534    Free PMC article.
Highly Cited.
Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells.
Martin Guilliams, Karine Crozat, +7 authors, Bernard Malissen.
Blood, 2010 Jan 14; 115(10). PMID: 20068222
Highly Cited.
Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo.
Stephen J Jenkins, Georgia Perona-Wright, +2 authors, Andrew S MacDonald.
J Immunol, 2007 Sep 06; 179(6). PMID: 17785785
A dual role for receptor-interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy.
Craig R Homer, Amrita Kabi, +6 authors, Christine McDonald.
J Biol Chem, 2012 Jun 06; 287(30). PMID: 22665475    Free PMC article.
Dendritic Cell Targeting Using a DNA Vaccine Induces Specific Antibodies and CD4+ T Cells to the Dengue Virus Envelope Protein Domain III.
Arthur Baruel Zaneti, Marcio Massao Yamamoto, +8 authors, Silvia Beatriz Boscardin.
Front Immunol, 2019 Feb 15; 10. PMID: 30761131    Free PMC article.
Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics.
Florian Adanitsch, Jianjin Shi, +3 authors, Alla Zamyatina.
Chem Sci, 2018 May 22; 9(16). PMID: 29780528    Free PMC article.
The multifaceted role of CD4(+) T cells in CD8(+) T cell memory.
Brian J Laidlaw, Joseph E Craft, Susan M Kaech.
Nat Rev Immunol, 2016 Jan 20; 16(2). PMID: 26781939    Free PMC article.
Highly Cited. Review.
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.
R Manetti, P Parronchi, +4 authors, S Romagnani.
J Exp Med, 1993 Apr 01; 177(4). PMID: 8096238    Free PMC article.
Highly Cited.
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.
Lionel Apetoh, François Ghiringhelli, +25 authors, Laurence Zitvogel.
Nat Med, 2007 Aug 21; 13(9). PMID: 17704786
Highly Cited.
Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex.
K Ohashi, V Burkart, S Flohé, H Kolb.
J Immunol, 2000 Jan 07; 164(2). PMID: 10623794
Highly Cited.
Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions.
Sarah Eickhoff, Anna Brewitz, +7 authors, Wolfgang Kastenmüller.
Cell, 2015 Aug 25; 162(6). PMID: 26296422    Free PMC article.
Highly Cited.
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis.
Jeremy B Swann, Matthew D Vesely, +4 authors, Mark J Smyth.
Proc Natl Acad Sci U S A, 2008 Jan 08; 105(2). PMID: 18178624    Free PMC article.
Highly Cited.
Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice.
María Martínez-López, Salvador Iborra, Ruth Conde-Garrosa, David Sancho.
Eur J Immunol, 2014 Oct 15; 45(1). PMID: 25312824    Free PMC article.
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.
Wan-ting He, Haoqiang Wan, +6 authors, Jiahuai Han.
Cell Res, 2015 Nov 28; 25(12). PMID: 26611636    Free PMC article.
Highly Cited.
Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage.
Regine J Dress, Charles-Antoine Dutertre, +15 authors, Florent Ginhoux.
Nat Immunol, 2019 Jun 20; 20(7). PMID: 31213723
Highly Cited.
Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma.
Fujimasa Tada, Masanori Abe, +8 authors, Morikazu Onji.
Int J Oncol, 2012 Sep 14; 41(5). PMID: 22971679    Free PMC article.
MDA5 and LGP2: accomplices and antagonists of antiviral signal transduction.
Kenny R Rodriguez, Annie M Bruns, Curt M Horvath.
J Virol, 2014 May 23; 88(15). PMID: 24850739    Free PMC article.
Review.
Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis.
Giovanna Schiavoni, Antonella Sistigu, +10 authors, Laura Bracci.
Cancer Res, 2010 Dec 16; 71(3). PMID: 21156650
Highly Cited.
Mincle is an ITAM-coupled activating receptor that senses damaged cells.
Sho Yamasaki, Eri Ishikawa, +3 authors, Takashi Saito.
Nat Immunol, 2008 Sep 09; 9(10). PMID: 18776906
Highly Cited.
Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity.
Adam D Cohen, Adi Diab, +9 authors, Alan N Houghton.
Cancer Res, 2006 May 03; 66(9). PMID: 16651447    Free PMC article.
Distinct dendritic cell subsets differentially regulate the class of immune response in vivo.
B Pulendran, J L Smith, +4 authors, C R Maliszewski.
Proc Natl Acad Sci U S A, 1999 Feb 03; 96(3). PMID: 9927689    Free PMC article.
Highly Cited.
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity.
Hiroki Ishikawa, Zhe Ma, Glen N Barber.
Nature, 2009 Sep 25; 461(7265). PMID: 19776740    Free PMC article.
Highly Cited.
TLR8: the forgotten relative revindicated.
Jorge L Cervantes, Bennett Weinerman, Chaitali Basole, Juan C Salazar.
Cell Mol Immunol, 2012 Oct 23; 9(6). PMID: 23085951    Free PMC article.
Review.
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates.
Andreas Pichlmair, Oliver Schulz, +4 authors, Caetano Reis e Sousa.
Science, 2006 Oct 14; 314(5801). PMID: 17038589
Highly Cited.
Engagement of the OX-40 receptor in vivo enhances antitumor immunity.
A D Weinberg, M M Rivera, +7 authors, J Shields.
J Immunol, 2000 Feb 05; 164(4). PMID: 10657670
Highly Cited.
CpG-oligodeoxynucleotides developed for grouper toll-like receptor (TLR) 21s effectively activate mouse and human TLR9s mediated immune responses.
Da-Wei Yeh, Chao-Yang Lai, +7 authors, Tsung-Hsien Chuang.
Sci Rep, 2017 Dec 13; 7(1). PMID: 29229937    Free PMC article.
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Lijun Sun, Jiaxi Wu, +2 authors, Zhijian J Chen.
Science, 2012 Dec 22; 339(6121). PMID: 23258413    Free PMC article.
Highly Cited.
Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
Yan Gao, Simone A Nish, +5 authors, Ruslan Medzhitov.
Immunity, 2013 Oct 01; 39(4). PMID: 24076050    Free PMC article.
Highly Cited.
Current State of Dendritic Cell-Based Immunotherapy: Opportunities for in vitro Antigen Loading of Different DC Subsets?
Anne Huber, Floris Dammeijer, Joachim G J V Aerts, Heleen Vroman.
Front Immunol, 2018 Dec 19; 9. PMID: 30559743    Free PMC article.
Review.
OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity.
Pejman Soroosh, Shouji Ine, Kazuo Sugamura, Naoto Ishii.
J Immunol, 2006 May 04; 176(10). PMID: 16670306
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity.
David Sancho, Olivier P Joffre, +5 authors, Caetano Reis e Sousa.
Nature, 2009 Feb 17; 458(7240). PMID: 19219027    Free PMC article.
Highly Cited.
Localized expression of GITR-L in the tumor microenvironment promotes CD8+ T cell dependent anti-tumor immunity.
John S Cho, Jeffrey V Hsu, Sherie L Morrison.
Cancer Immunol Immunother, 2008 Nov 20; 58(7). PMID: 19018533    Free PMC article.
Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade.
Nicolas Jacquelot, Takahiro Yamazaki, +30 authors, Laurence Zitvogel.
Cell Res, 2019 Sep 05; 29(10). PMID: 31481761    Free PMC article.
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Jane Tian, Ana Maria Avalos, +19 authors, Anthony J Coyle.
Nat Immunol, 2007 Apr 10; 8(5). PMID: 17417641
Highly Cited.
Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.
H Tahara, L Zitvogel, +6 authors, M T Lotze.
J Immunol, 1995 Jun 15; 154(12). PMID: 7759882
PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity.
Sarah L Buchan, Mohannad Fallatah, +8 authors, Aymen Al-Shamkhani.
Clin Cancer Res, 2018 Mar 09; 24(10). PMID: 29514845    Free PMC article.
Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment.
Gordon F Heidkamp, Jil Sander, +28 authors, Diana Dudziak.
Sci Immunol, 2017 Aug 08; 1(6). PMID: 28783692
Highly Cited.
Ontogenic, Phenotypic, and Functional Characterization of XCR1(+) Dendritic Cells Leads to a Consistent Classification of Intestinal Dendritic Cells Based on the Expression of XCR1 and SIRPα.
Martina Becker, Steffen Güttler, +8 authors, Richard A Kroczek.
Front Immunol, 2014 Aug 15; 5. PMID: 25120540    Free PMC article.
FcgammaRIV: a novel FcR with distinct IgG subclass specificity.
Falk Nimmerjahn, Pierre Bruhns, Ken Horiuchi, Jeffrey V Ravetch.
Immunity, 2005 Jul 26; 23(1). PMID: 16039578
Highly Cited.
The NLRP3 inflammasome: molecular activation and regulation to therapeutics.
Karen V Swanson, Meng Deng, Jenny P-Y Ting.
Nat Rev Immunol, 2019 May 01; 19(8). PMID: 31036962    Free PMC article.
Highly Cited. Review.
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies.
Jérôme Galon, Daniela Bruni.
Nat Rev Drug Discov, 2019 Jan 06; 18(3). PMID: 30610226
Highly Cited. Review.
Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.
Udupi A Ramagopal, Weifeng Liu, +10 authors, Steven C Almo.
Proc Natl Acad Sci U S A, 2017 May 10; 114(21). PMID: 28484017    Free PMC article.
Deciphering the transcriptional network of the dendritic cell lineage.
Jennifer C Miller, Brian D Brown, +18 authors, Immunological Genome Consortium.
Nat Immunol, 2012 Jul 17; 13(9). PMID: 22797772    Free PMC article.
Highly Cited.
Defective CD8 T cell memory following acute infection without CD4 T cell help.
Joseph C Sun, Michael J Bevan.
Science, 2003 Apr 12; 300(5617). PMID: 12690202    Free PMC article.
Highly Cited.
The presence of T cell epitopes is important for induction of antibody responses against antigens directed to DEC205+ dendritic cells.
Kelly N S Amorim, Eline V Rampazo, +4 authors, Silvia B Boscardin.
Sci Rep, 2016 Dec 22; 6. PMID: 28000705    Free PMC article.
NOD proteins: regulators of inflammation in health and disease.
Dana J Philpott, Matthew T Sorbara, +2 authors, Stephen E Girardin.
Nat Rev Immunol, 2013 Dec 18; 14(1). PMID: 24336102
Highly Cited. Review.
Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific for Endocytic Receptors as a Promising Strategy for Future Therapies.
Christian H K Lehmann, Lukas Heger, +4 authors, Diana Dudziak.
Vaccines (Basel), 2016 Apr 05; 4(2). PMID: 27043640    Free PMC article.
Review.
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms.
Richard V Parry, Jens M Chemnitz, +6 authors, James L Riley.
Mol Cell Biol, 2005 Oct 18; 25(21). PMID: 16227604    Free PMC article.
Highly Cited.
Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens.
Kathryn J Farrand, Nina Dickgreber, +3 authors, Ian F Hermans.
J Immunol, 2009 Nov 20; 183(12). PMID: 19923446
Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells.
F Takeshita, C A Leifer, +4 authors, D M Klinman.
J Immunol, 2001 Sep 21; 167(7). PMID: 11564765
Highly Cited.
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.
Sarah M McWhirter, Roman Barbalat, +10 authors, Russell E Vance.
J Exp Med, 2009 Aug 05; 206(9). PMID: 19652017    Free PMC article.
Highly Cited.
Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells.
Miriam Merad, Florent Ginhoux, Matthew Collin.
Nat Rev Immunol, 2008 Nov 26; 8(12). PMID: 19029989
Highly Cited. Review.
Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies.
Raanan Berger, Rinat Rotem-Yehudar, +6 authors, Arnon Nagler.
Clin Cancer Res, 2008 May 17; 14(10). PMID: 18483370
Highly Cited.
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.
Haidong Dong, Scott E Strome, +10 authors, Lieping Chen.
Nat Med, 2002 Jul 02; 8(8). PMID: 12091876
Highly Cited.
Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population.
Rebecca Leylek, Marcela Alcántara-Hernández, +4 authors, Juliana Idoyaga.
Cell Rep, 2019 Dec 12; 29(11). PMID: 31825848    Free PMC article.
Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/beta.
Marc Dalod, Tanya Hamilton, +4 authors, Christine A Biron.
J Exp Med, 2003 Apr 19; 197(7). PMID: 12682109    Free PMC article.
Highly Cited.
Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets.
Diego Piccioli, Simona Tavarini, +7 authors, Andreas Wack.
Blood, 2007 Mar 03; 109(12). PMID: 17332250
Adjuvant immunotherapy with autologous dendritic cells for hepatocellular carcinoma, randomized phase II study.
Jeong-Hoon Lee, Won Young Tak, +10 authors, Yoon Jun Kim.
Oncoimmunology, 2017 Aug 16; 6(7). PMID: 28811965    Free PMC article.
Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability.
N Romani, D Reider, +5 authors, G Schuler.
J Immunol Methods, 1996 Sep 27; 196(2). PMID: 8841452
Highly Cited.
Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells.
Sammy Bedoui, Paul G Whitney, +9 authors, William R Heath.
Nat Immunol, 2009 Apr 08; 10(5). PMID: 19349986
Highly Cited.
Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague.
Yoonkyung Do, Hyein Koh, +9 authors, Ralph M Steinman.
Eur J Immunol, 2010 Sep 03; 40(10). PMID: 20812236
Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.
Jörg H Fritz, Lionel Le Bourhis, +8 authors, Dana J Philpott.
Immunity, 2007 Apr 17; 26(4). PMID: 17433730
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
Nobuhiko Kayagaki, Irma B Stowe, +22 authors, Vishva M Dixit.
Nature, 2015 Sep 17; 526(7575). PMID: 26375259
Highly Cited.
Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants.
Thomas W Dubensky, David B Kanne, Meredith L Leong.
Ther Adv Vaccines, 2014 Apr 24; 1(4). PMID: 24757520    Free PMC article.
Review.
Toll-like receptor 3 promotes cross-priming to virus-infected cells.
Oliver Schulz, Sandra S Diebold, +7 authors, Caetano Reis e Sousa.
Nature, 2005 Feb 16; 433(7028). PMID: 15711573
Highly Cited.
The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells.
Gerty Schreibelt, Lieke J J Klinkenberg, +7 authors, I Jolanda M de Vries.
Blood, 2012 Jan 12; 119(10). PMID: 22234694
Highly Cited.
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
Andrea Ablasser, Jonathan L Schmid-Burgk, +4 authors, Veit Hornung.
Nature, 2013 Oct 01; 503(7477). PMID: 24077100    Free PMC article.
Highly Cited.
The protective effect of the anti-Toll-like receptor 9 antibody against acute cytokine storm caused by immunostimulatory DNA.
Yusuke Murakami, Ryutaro Fukui, +4 authors, Kensuke Miyake.
Sci Rep, 2017 Mar 08; 7. PMID: 28266597    Free PMC article.
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance.
Jun Shimizu, Sayuri Yamazaki, +2 authors, Shimon Sakaguchi.
Nat Immunol, 2002 Jan 29; 3(2). PMID: 11812990
Highly Cited.
Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.
Osamu Takeuchi, Shintaro Sato, +5 authors, Shizuo Akira.
J Immunol, 2002 Jun 22; 169(1). PMID: 12077222
Highly Cited.
Dendritic cell-based nanovaccines for cancer immunotherapy.
Leonie E Paulis, Subhra Mandal, Martin Kreutz, Carl G Figdor.
Curr Opin Immunol, 2013 Apr 11; 25(3). PMID: 23571027
Review.
STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment.
Steven Lohard, Nathalie Bourgeois, +15 authors, Sophie Barillé-Nion.
Nat Commun, 2020 Jan 16; 11(1). PMID: 31937780    Free PMC article.
Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.
Warrison A Andrade, Maria do Carmo Souza, +7 authors, Ricardo T Gazzinelli.
Cell Host Microbe, 2013 Jan 08; 13(1). PMID: 23290966    Free PMC article.
Highly Cited.
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.
F Sallusto, A Lanzavecchia.
J Exp Med, 1994 Apr 01; 179(4). PMID: 8145033    Free PMC article.
Highly Cited.
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors.
Elizabeth A Leadbetter, Ian R Rifkin, +3 authors, Ann Marshak-Rothstein.
Nature, 2002 Apr 12; 416(6881). PMID: 11948342
Highly Cited.
Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.
Alice O Kamphorst, Andreas Wieland, +17 authors, Rafi Ahmed.
Science, 2017 Mar 11; 355(6332). PMID: 28280249    Free PMC article.
Highly Cited.
The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells.
H Kitamura, K Iwakabe, +10 authors, T Nishimura.
J Exp Med, 1999 Apr 06; 189(7). PMID: 10190903    Free PMC article.
Highly Cited.
NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.
Hexin Shi, Ying Wang, +21 authors, Bruce Beutler.
Nat Immunol, 2015 Dec 08; 17(3). PMID: 26642356    Free PMC article.
Highly Cited.
DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.
David Roulois, Helen Loo Yau, +9 authors, Daniel D De Carvalho.
Cell, 2015 Sep 01; 162(5). PMID: 26317465    Free PMC article.
Highly Cited.
Langerhans cells cross-present antigen derived from skin.
Patrizia Stoitzner, Christoph H Tripp, +5 authors, Nikolaus Romani.
Proc Natl Acad Sci U S A, 2006 May 05; 103(20). PMID: 16672373    Free PMC article.
Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34(+) progenitor-derived dendritic cells.
Joseph W Fay, A Karolina Palucka, +5 authors, Jacques Banchereau.
Cancer Immunol Immunother, 2005 Dec 07; 55(10). PMID: 16331519
The origins and functions of dendritic cells and macrophages in the skin.
Bernard Malissen, Samira Tamoutounour, Sandrine Henri.
Nat Rev Immunol, 2014 May 24; 14(6). PMID: 24854591
Highly Cited. Review.
Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer.
Clemence Granier, Eleonore De Guillebon, +7 authors, Eric Tartour.
ESMO Open, 2017 Aug 02; 2(2). PMID: 28761757    Free PMC article.
Highly Cited. Review.
T cell exclusion, immune privilege, and the tumor microenvironment.
Johanna A Joyce, Douglas T Fearon.
Science, 2015 Apr 04; 348(6230). PMID: 25838376
Highly Cited. Review.
Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer.
Leticia Corrales, Thomas F Gajewski.
Clin Cancer Res, 2015 Sep 17; 21(21). PMID: 26373573    Free PMC article.
Review.
T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.
Boryana N Manz, Bryan L Jackson, +2 authors, Jay Groves.
Proc Natl Acad Sci U S A, 2011 May 18; 108(22). PMID: 21576490    Free PMC article.
Highly Cited.
Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling-Induced Nontranscriptional Priming of the NLRP3 Inflammasome.
Yue Xing, Xiaomin Yao, +6 authors, Guangxun Meng.
J Immunol, 2017 Jul 26; 199(5). PMID: 28739881
The lineage decisions of helper T cells.
Kenneth M Murphy, Steven L Reiner.
Nat Rev Immunol, 2002 Dec 04; 2(12). PMID: 12461566
Highly Cited. Review.
Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors.
Baidong Hou, Alicia Benson, +2 authors, Felix Yarovinsky.
Proc Natl Acad Sci U S A, 2010 Dec 22; 108(1). PMID: 21173242    Free PMC article.
Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts.
Sergio A Quezada, Tyler R Simpson, +9 authors, James P Allison.
J Exp Med, 2010 Feb 17; 207(3). PMID: 20156971    Free PMC article.
Highly Cited.
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.
Melissa A Kinnebrew, Charlie G Buffie, +6 authors, Eric G Pamer.
Immunity, 2012 Feb 07; 36(2). PMID: 22306017    Free PMC article.
Highly Cited.
In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology.
Susmit Suvas, Bumseok Kim, +3 authors, Barry T Rouse.
J Virol, 2005 Sep 06; 79(18). PMID: 16140769    Free PMC article.
Neoantigens in cancer immunotherapy.
Ton N Schumacher, Robert D Schreiber.
Science, 2015 Apr 04; 348(6230). PMID: 25838375
Highly Cited. Review.
Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.
M A Campos, I C Almeida, +7 authors, R T Gazzinelli.
J Immunol, 2001 Jun 22; 167(1). PMID: 11418678
Highly Cited.
Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function.
Julie M Curtsinger, Debra C Lins, Matthew F Mescher.
J Exp Med, 2003 May 07; 197(9). PMID: 12732656    Free PMC article.
Highly Cited.
Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells.
Anita Sapoznikov, Jens A A Fischer, +3 authors, Steffen Jung.
J Exp Med, 2007 Jul 25; 204(8). PMID: 17646404    Free PMC article.
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.
Sandra S Diebold, Tsuneyasu Kaisho, +2 authors, Caetano Reis e Sousa.
Science, 2004 Feb 21; 303(5663). PMID: 14976261
Highly Cited.
Diversification of human plasmacytoid predendritic cells in response to a single stimulus.
Solana G Alculumbre, Violaine Saint-André, +15 authors, Vassili Soumelis.
Nat Immunol, 2017 Dec 06; 19(1). PMID: 29203862
CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells.
Simona Sivori, Michela Falco, +4 authors, Alessandro Moretta.
Proc Natl Acad Sci U S A, 2004 Jun 26; 101(27). PMID: 15218108    Free PMC article.
Highly Cited.
Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells.
Muzlifah Haniffa, Amanda Shin, +25 authors, Florent Ginhoux.
Immunity, 2012 Jul 17; 37(1). PMID: 22795876    Free PMC article.
Highly Cited.
Prospects for CD40-directed experimental therapy of human cancer.
Alex W Tong, Marvin J Stone.
Cancer Gene Ther, 2002 Dec 19; 10(1). PMID: 12489023
Review.
Immune modules shared by innate lymphoid cells and T cells.
Michelle L Robinette, Marco Colonna.
J Allergy Clin Immunol, 2016 Nov 08; 138(5). PMID: 27817796    Free PMC article.
Review.
GITR ligand fusion protein agonist enhances the tumor antigen-specific CD8 T-cell response and leads to long-lasting memory.
Nick M Durham, Nick Holoweckyj, +3 authors, Scott H Robbins.
J Immunother Cancer, 2017 Jun 27; 5. PMID: 28649380    Free PMC article.
Nivolumab plus ipilimumab in advanced melanoma.
Jedd D Wolchok, Harriet Kluger, +21 authors, Mario Sznol.
N Engl J Med, 2013 Jun 04; 369(2). PMID: 23724867    Free PMC article.
Highly Cited.
Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.
Henning Lauterbach, Barbara Bathke, +13 authors, Hubertus Hochrein.
J Exp Med, 2010 Oct 27; 207(12). PMID: 20975040    Free PMC article.
Highly Cited.
Different cross-presentation pathways in steady-state and inflammatory dendritic cells.
Elodie Segura, Anthony L Albiston, +2 authors, José A Villadangos.
Proc Natl Acad Sci U S A, 2009 Nov 18; 106(48). PMID: 19918052    Free PMC article.
SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis.
Ciriana Orabona, Maria T Pallotta, +7 authors, Paolo Puccetti.
Proc Natl Acad Sci U S A, 2008 Dec 18; 105(52). PMID: 19088199    Free PMC article.
Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.
B Kwon, K Y Yu, +7 authors, B S Kwon.
J Biol Chem, 1999 Feb 26; 274(10). PMID: 10037686
The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions.
Sonia Feau, Zacarias Garcia, +3 authors, Stephen P Schoenberger.
Nat Commun, 2012 Jul 12; 3. PMID: 22781761    Free PMC article.
FOXD3 Regulates VISTA Expression in Melanoma.
Sheera R Rosenbaum, Meghan Knecht, +11 authors, Andrew E Aplin.
Cell Rep, 2020 Jan 16; 30(2). PMID: 31940493    Free PMC article.
Toll-like receptor signalling.
Shizuo Akira, Kiyoshi Takeda.
Nat Rev Immunol, 2004 Jul 02; 4(7). PMID: 15229469
Highly Cited. Review.
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.
Alvin Lu, Venkat Giri Magupalli, +7 authors, Edward H Egelman.
Cell, 2014 Mar 19; 156(6). PMID: 24630722    Free PMC article.
Highly Cited.
BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction.
A Dzionek, Y Sohma, +14 authors, J Schmitz.
J Exp Med, 2001 Dec 19; 194(12). PMID: 11748283    Free PMC article.
Highly Cited.
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
Tadashi Yokosuka, Masako Takamatsu, +3 authors, Takashi Saito.
J Exp Med, 2012 May 30; 209(6). PMID: 22641383    Free PMC article.
Highly Cited.
Coinhibitory receptor PD-1H preferentially suppresses CD4⁺ T cell-mediated immunity.
Dallas B Flies, Xue Han, +4 authors, Lieping Chen.
J Clin Invest, 2014 Apr 20; 124(5). PMID: 24743150    Free PMC article.
Highly Cited.
PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer.
Brian Diskin, Salma Adam, +32 authors, George Miller.
Nat Immunol, 2020 Mar 11; 21(4). PMID: 32152508
CD8(+) T-cell priming and boosting: more antigen-presenting DC, or more antigen per DC?
Niels Schaft, Verena Wellner, +2 authors, Jan Dörrie.
Cancer Immunol Immunother, 2013 Oct 12; 62(12). PMID: 24114143
CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression.
L J Appleman, A Berezovskaya, I Grass, V A Boussiotis.
J Immunol, 1999 Dec 22; 164(1). PMID: 10605005
Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells.
R M Vabulas, P Ahmad-Nejad, +4 authors, H Wagner.
J Biol Chem, 2001 Jun 13; 276(33). PMID: 11402040
Highly Cited.
A monoclonal antibody specific for mouse dendritic cells.
M C Nussenzweig, R M Steinman, M D Witmer, B Gutchinov.
Proc Natl Acad Sci U S A, 1982 Jan 01; 79(1). PMID: 6948298    Free PMC article.
Highly Cited.
Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination.
Kristen A Batich, Elizabeth A Reap, +14 authors, John H Sampson.
Clin Cancer Res, 2017 Apr 16; 23(8). PMID: 28411277    Free PMC article.
Highly Cited.
Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses.
Eduardo J Villablanca, Laura Raccosta, +15 authors, Vincenzo Russo.
Nat Med, 2009 Dec 29; 16(1). PMID: 20037595
Structural basis of toll-like receptor 3 signaling with double-stranded RNA.
Lin Liu, Istvan Botos, +4 authors, David R Davies.
Science, 2008 Apr 19; 320(5874). PMID: 18420935    Free PMC article.
Highly Cited.
Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice.
Cheng-Hu Liu, Yu-ting Fan, +5 authors, Julio Aliberti.
J Immunol, 2006 Jun 21; 177(1). PMID: 16785494
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota.
Marie Vétizou, Jonathan M Pitt, +35 authors, Laurence Zitvogel.
Science, 2015 Nov 07; 350(6264). PMID: 26541610    Free PMC article.
Highly Cited.
Profiling MHC II immunopeptidome of blood-stage malaria reveals that cDC1 control the functionality of parasite-specific CD4 T cells.
Marion Draheim, Myriam F Wlodarczyk, +12 authors, Nicolas Blanchard.
EMBO Mol Med, 2017 Sep 25; 9(11). PMID: 28935714    Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection.
Cedric Bosteels, Katrijn Neyt, +18 authors, Bart N Lambrecht.
Immunity, 2020 May 12; 52(6). PMID: 32392463    Free PMC article.
Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4+ and CD8+ T Cell Activation to Localized Viral Infection.
Jyh Liang Hor, Paul G Whitney, +3 authors, Scott N Mueller.
Immunity, 2015 Aug 25; 43(3). PMID: 26297566
Highly Cited.
Antibody humanization methods - a review and update.
Yaghoub Safdari, Safar Farajnia, Mohammad Asgharzadeh, Masoumeh Khalili.
Biotechnol Genet Eng Rev, 2014 Feb 27; 29. PMID: 24568279
Review.
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Franz G Bauernfeind, Gabor Horvath, +9 authors, Eicke Latz.
J Immunol, 2009 Jul 03; 183(2). PMID: 19570822    Free PMC article.
Highly Cited.
Impact of oncogenic pathways on evasion of antitumour immune responses.
Stefani Spranger, Thomas F Gajewski.
Nat Rev Cancer, 2018 Jan 13; 18(3). PMID: 29326431    Free PMC article.
Highly Cited. Review.
IDO expression by dendritic cells: tolerance and tryptophan catabolism.
Andrew L Mellor, David H Munn.
Nat Rev Immunol, 2004 Oct 02; 4(10). PMID: 15459668
Highly Cited. Review.
Fcgamma receptors: old friends and new family members.
Falk Nimmerjahn, Jeffrey V Ravetch.
Immunity, 2006 Jan 18; 24(1). PMID: 16413920
Highly Cited. Review.
In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles.
Young Jik Kwon, Edward James, Nilabh Shastri, Jean M J Fréchet.
Proc Natl Acad Sci U S A, 2005 Dec 14; 102(51). PMID: 16344458    Free PMC article.
Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation.
Austin Pantel, Angela Teixeira, +3 authors, M Paula Longhi.
PLoS Biol, 2014 Jan 11; 12(1). PMID: 24409099    Free PMC article.
Highly Cited.
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.
Thomas Korn, Estelle Bettelli, +5 authors, Vijay K Kuchroo.
Nature, 2007 Jun 22; 448(7152). PMID: 17581588    Free PMC article.
Highly Cited.
Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti-CTLA-4 therapy.
Derek Ng Tang, Yu Shen, +5 authors, Padmanee Sharma.
Cancer Immunol Res, 2014 Apr 30; 1(4). PMID: 24777852    Free PMC article.
Highly Cited.
A conserved dendritic-cell regulatory program limits antitumour immunity.
Barbara Maier, Andrew M Leader, +20 authors, Miriam Merad.
Nature, 2020 Apr 10; 580(7802). PMID: 32269339    Free PMC article.
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.
H Dong, G Zhu, K Tamada, L Chen.
Nat Med, 1999 Dec 02; 5(12). PMID: 10581077
Highly Cited.
IRF family proteins and type I interferon induction in dendritic cells.
Prafullakumar Tailor, Tomohiko Tamura, Keiko Ozato.
Cell Res, 2006 Feb 14; 16(2). PMID: 16474425
Review.
Glycan-Based Cell Targeting To Modulate Immune Responses.
Timo Johannssen, Bernd Lepenies.
Trends Biotechnol, 2017 Mar 10; 35(4). PMID: 28277249
Review.
Mitochondrial double-stranded RNA triggers antiviral signalling in humans.
Ashish Dhir, Somdutta Dhir, +15 authors, Nicholas J Proudfoot.
Nature, 2018 Jul 27; 560(7717). PMID: 30046113    Free PMC article.
Highly Cited.
Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs.
Tiffany F Chen, Stephen L Sazinsky, +8 authors, K Dane Wittrup.
J Mol Biol, 2017 Jul 12; 429(16). PMID: 28694069    Free PMC article.
Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions.
A I Chen, A J McAdam, +8 authors, A H Sharpe.
Immunity, 2000 Jan 08; 11(6). PMID: 10626891
OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors.
Y Ohshima, L P Yang, +5 authors, G Delespesse.
Blood, 1998 Oct 27; 92(9). PMID: 9787171
CD70 is downregulated by interaction with CD27.
Mirela Kuka, Ivana Munitic, Maria Letizia Giardino Torchia, Jonathan D Ashwell.
J Immunol, 2013 Aug 06; 191(5). PMID: 23913967    Free PMC article.
Elements of cancer immunity and the cancer-immune set point.
Daniel S Chen, Ira Mellman.
Nature, 2017 Jan 20; 541(7637). PMID: 28102259
Highly Cited. Review.
Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation.
Sadeem Ahmad, Xin Mu, +5 authors, Sun Hur.
Cell, 2018 Feb 06; 172(4). PMID: 29395326    Free PMC article.
Highly Cited.
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Jianjin Shi, Yue Zhao, +7 authors, Feng Shao.
Nature, 2015 Sep 17; 526(7575). PMID: 26375003
Highly Cited.
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis.
Yan Zheng, Dimitry M Danilenko, +4 authors, Wenjun Ouyang.
Nature, 2006 Dec 26; 445(7128). PMID: 17187052
Highly Cited.
C-type lectin receptors on dendritic cells and Langerhans cells.
Carl G Figdor, Yvette van Kooyk, Gosse J Adema.
Nat Rev Immunol, 2002 Mar 26; 2(2). PMID: 11910898
Highly Cited. Review.
Dendritic cell migration in health and disease.
Tim Worbs, Swantje I Hammerschmidt, Reinhold Förster.
Nat Rev Immunol, 2016 Nov 29; 17(1). PMID: 27890914
Highly Cited. Review.
CLEC12A-Mediated Antigen Uptake and Cross-Presentation by Human Dendritic Cell Subsets Efficiently Boost Tumor-Reactive T Cell Responses.
Tim J A Hutten, Soley Thordardottir, +13 authors, Willemijn Hobo.
J Immunol, 2016 Aug 28; 197(7). PMID: 27566820
Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues.
Hong Chen, Chrysoula I Liakou, +8 authors, Padmanee Sharma.
Proc Natl Acad Sci U S A, 2009 Feb 10; 106(8). PMID: 19202079    Free PMC article.
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2.
T Shiratori, S Miyatake, +4 authors, T Saito.
Immunity, 1997 May 01; 6(5). PMID: 9175836
Ontogeny and function of murine epidermal Langerhans cells.
Daniel H Kaplan.
Nat Immunol, 2017 Sep 20; 18(10). PMID: 28926543    Free PMC article.
Review.
Preclinical evaluation of NF-κB-triggered dendritic cells expressing the viral oncogenic driver of Merkel cell carcinoma for therapeutic vaccination.
Kerstin F Gerer, Michael Erdmann, +8 authors, Jan Dörrie.
Ther Adv Med Oncol, 2017 Jul 19; 9(7). PMID: 28717398    Free PMC article.
VISTA Regulates the Development of Protective Antitumor Immunity.
Isabelle Le Mercier, Wenna Chen, +5 authors, Li Wang.
Cancer Res, 2014 Apr 03; 74(7). PMID: 24691994    Free PMC article.
Highly Cited.
Rapid induction of tumor-specific type 1 T helper cells in metastatic melanoma patients by vaccination with mature, cryopreserved, peptide-loaded monocyte-derived dendritic cells.
Beatrice Schuler-Thurner, Erwin S Schultz, +8 authors, Gerold Schuler.
J Exp Med, 2002 May 22; 195(10). PMID: 12021308    Free PMC article.
Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice.
Gabrielle T Belz, Dominik Wodarz, +2 authors, Peter C Doherty.
J Virol, 2002 Nov 05; 76(23). PMID: 12414983    Free PMC article.
Highly Cited.
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes.
Edith M Janssen, Edward E Lemmens, +3 authors, Stephen P Schoenberger.
Nature, 2003 Feb 21; 421(6925). PMID: 12594515
Highly Cited.
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.
A O Aliprantis, R B Yang, +6 authors, A Zychlinsky.
Science, 1999 Jul 31; 285(5428). PMID: 10426996
Highly Cited.
Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells.
Brian Ruffell, Debbie Chang-Strachan, +7 authors, Lisa M Coussens.
Cancer Cell, 2014 Dec 03; 26(5). PMID: 25446896    Free PMC article.
Highly Cited.
Pore-forming activity and structural autoinhibition of the gasdermin family.
Jingjin Ding, Kun Wang, +6 authors, Feng Shao.
Nature, 2016 Jun 10; 535(7610). PMID: 27281216
Highly Cited.
Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon.
Agnes Le Bon, Nathalie Etchart, +5 authors, David F Tough.
Nat Immunol, 2003 Sep 23; 4(10). PMID: 14502286
Highly Cited.
Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice.
M J Mendez, L L Green, +20 authors, A Jakobovits.
Nat Genet, 1997 Feb 01; 15(2). PMID: 9020839
STING manifests self DNA-dependent inflammatory disease.
Jeonghyun Ahn, Delia Gutman, Shinobu Saijo, Glen N Barber.
Proc Natl Acad Sci U S A, 2012 Nov 08; 109(47). PMID: 23132945    Free PMC article.
Highly Cited.
A liposome-based antigen delivery system using pH-sensitive fusogenic polymers for cancer immunotherapy.
Eiji Yuba, Atsushi Harada, +2 authors, Kenji Kono.
Biomaterials, 2013 Feb 05; 34(12). PMID: 23374704
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
O Takeuchi, K Hoshino, +5 authors, S Akira.
Immunity, 1999 Nov 05; 11(4). PMID: 10549626
Highly Cited.
TLR-dependent T cell activation in autoimmunity.
Kingston H G Mills.
Nat Rev Immunol, 2011 Nov 19; 11(12). PMID: 22094985
Highly Cited. Review.
Immunogenicity to Biotherapeutics - The Role of Anti-drug Immune Complexes.
Murli Krishna, Steven G Nadler.
Front Immunol, 2016 Feb 13; 7. PMID: 26870037    Free PMC article.
Highly Cited. Review.
CD180 Ligation Inhibits TLR7- and TLR9-Mediated Activation of Macrophages and Dendritic Cells Through the Lyn-SHP-1/2 Axis in Murine Lupus.
Yonghong Yang, Cuiling Wang, +7 authors, Huabao Xiong.
Front Immunol, 2018 Dec 01; 9. PMID: 30498494    Free PMC article.
Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma.
Einar Osland Vik-Mo, Marta Nyakas, +13 authors, Iver A Langmoen.
Cancer Immunol Immunother, 2013 Jul 03; 62(9). PMID: 23817721    Free PMC article.
Highly Cited.
The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells.
Yan Wang, Jernej Godec, +7 authors, Vanja Lazarevic.
Immunity, 2014 Feb 18; 40(3). PMID: 24530058    Free PMC article.
Highly Cited.
Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life.
Tomer Granot, Takashi Senda, +12 authors, Donna L Farber.
Immunity, 2017 Mar 23; 46(3). PMID: 28329707    Free PMC article.
Highly Cited.
Efficient immune responses against Intimin and EspB of enterohaemorragic Escherichia coli after intranasal vaccination using the TLR2/6 agonist MALP-2 as adjuvant.
Angel Cataldi, Tetyana Yevsa, +6 authors, Carlos A Guzmán.
Vaccine, 2008 Aug 05; 26(44). PMID: 18675866
The GITRL-GITR system alters TLR-4 expression on DC during fungal infection.
Anna Vecchiarelli, Eva Pericolini, +5 authors, Carlo Riccardi.
Cell Immunol, 2009 Mar 11; 257(1-2). PMID: 19272591
Non-apoptotic role of BID in inflammation and innate immunity.
Garabet Yeretssian, Ricardo G Correa, +5 authors, Maya Saleh.
Nature, 2011 May 10; 474(7349). PMID: 21552281
Critical Role for Skin-Derived Migratory DCs and Langerhans Cells in TFH and GC Responses after Intradermal Immunization.
Clément Levin, Olivia Bonduelle, +4 authors, Béhazine Combadière.
J Invest Dermatol, 2017 May 02; 137(9). PMID: 28457909
Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responses.
Elizabeth B Wilson, Alexandra M Livingstone.
J Immunol, 2008 Nov 20; 181(11). PMID: 19017930
Fcγ receptor antigen targeting potentiates cross-presentation by human blood and lymphoid tissue BDCA-3+ dendritic cells.
Thijs W H Flinsenberg, Ewoud B Compeer, +5 authors, Marianne Boes.
Blood, 2012 Oct 25; 120(26). PMID: 23093620
Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood.
A Bender, M Sapp, +2 authors, N Bhardwaj.
J Immunol Methods, 1996 Sep 27; 196(2). PMID: 8841451
Highly Cited.
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species.
Martin Guilliams, Charles-Antoine Dutertre, +29 authors, Florent Ginhoux.
Immunity, 2016 Sep 18; 45(3). PMID: 27637149    Free PMC article.
Highly Cited.
Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection.
Manfred Brigl, Raju V V Tatituri, +7 authors, Michael B Brenner.
J Exp Med, 2011 May 11; 208(6). PMID: 21555485    Free PMC article.
Highly Cited.
Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition.
Hélène Salmon, Juliana Idoyaga, +19 authors, Miriam Merad.
Immunity, 2016 Apr 21; 44(4). PMID: 27096321    Free PMC article.
Highly Cited.
The clinical application of cancer immunotherapy based on naturally circulating dendritic cells.
Kalijn F Bol, Gerty Schreibelt, +11 authors, I Jolanda M de Vries.
J Immunother Cancer, 2019 Apr 20; 7(1). PMID: 30999964    Free PMC article.
Highly Cited. Review.
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.
Leonardo H Travassos, Leticia A M Carneiro, +13 authors, Dana J Philpott.
Nat Immunol, 2009 Nov 10; 11(1). PMID: 19898471
Highly Cited.
Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells.
Venetia Bigley, Naomi McGovern, +5 authors, Matthew Collin.
J Leukoc Biol, 2014 Dec 18; 97(4). PMID: 25516751    Free PMC article.
Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein.
L M Higgins, S A McDonald, +3 authors, T T MacDonald.
J Immunol, 1999 Jan 14; 162(1). PMID: 9886424
CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses.
Fernanda V V Castro, Alison L Tutt, +4 authors, Martin J Glennie.
Eur J Immunol, 2008 Jul 25; 38(8). PMID: 18651710
Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help.
S R Bennett, F R Carbone, +2 authors, W R Heath.
J Exp Med, 1997 Jul 07; 186(1). PMID: 9206998    Free PMC article.
Highly Cited.
The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon.
Chen Wang, Taoyong Chen, +4 authors, Xuetao Cao.
Nat Immunol, 2009 Jun 02; 10(7). PMID: 19483718
Highly Cited.
Adaptive immune activation: glycosylation does matter.
Margreet A Wolfert, Geert-Jan Boons.
Nat Chem Biol, 2013 Nov 16; 9(12). PMID: 24231619    Free PMC article.
Highly Cited.
Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation.
Jesse W Williams, Melissa Y Tjota, +9 authors, Anne I Sperling.
Nat Commun, 2013 Dec 21; 4. PMID: 24356538    Free PMC article.
Highly Cited.
Enhanced antitumor immunity by targeting dendritic cells with tumor cell lysate-loaded chitosan nanoparticles vaccine.
Gao-Na Shi, Chuang-Nian Zhang, +8 authors, De-Ling Kong.
Biomaterials, 2016 Nov 07; 113. PMID: 27816821
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation.
Rachel Cooney, John Baker, +7 authors, Alison Simmons.
Nat Med, 2009 Dec 08; 16(1). PMID: 19966812
Highly Cited.
Human TLR10 is an anti-inflammatory pattern-recognition receptor.
Marije Oosting, Shih-Chin Cheng, +13 authors, Leo A B Joosten.
Proc Natl Acad Sci U S A, 2014 Oct 08; 111(42). PMID: 25288745    Free PMC article.
Highly Cited.
TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles).
Y Xing, R Cao, H-M Hu.
Cell Death Dis, 2016 Aug 05; 7(8). PMID: 27490927    Free PMC article.
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism.
Janine L Coombes, Karima R R Siddiqui, +4 authors, Fiona Powrie.
J Exp Med, 2007 Jul 11; 204(8). PMID: 17620361    Free PMC article.
Highly Cited.
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Christopher Lupfer, Paul G Thomas, +13 authors, Thirumala-Devi Kanneganti.
Nat Immunol, 2013 Mar 26; 14(5). PMID: 23525089    Free PMC article.
Highly Cited.
CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen.
D Vremec, J Pooley, +2 authors, K Shortman.
J Immunol, 2000 Mar 08; 164(6). PMID: 10706685
Highly Cited.
Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis.
T K Means, S Wang, +3 authors, M J Fenton.
J Immunol, 1999 Sep 22; 163(7). PMID: 10490993
Highly Cited.
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Hiroki Kato, Osamu Takeuchi, +15 authors, Shizuo Akira.
Nature, 2006 Apr 21; 441(7089). PMID: 16625202
Highly Cited.
MicroRNAs regulate dendritic cell differentiation and function.
Marian L Turner, Frauke M Schnorfeil, Thomas Brocker.
J Immunol, 2011 Oct 05; 187(8). PMID: 21969315
Review.
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.
Andrea Ablasser, Franz Bauernfeind, +3 authors, Veit Hornung.
Nat Immunol, 2009 Jul 18; 10(10). PMID: 19609254    Free PMC article.
Highly Cited.
The development and function of dendritic cell populations and their regulation by miRNAs.
Haibo Zhou, Li Wu.
Protein Cell, 2017 Apr 02; 8(7). PMID: 28364278    Free PMC article.
Review.
Prevention of allogeneic fetal rejection by tryptophan catabolism.
D H Munn, M Zhou, +5 authors, A L Mellor.
Science, 1998 Aug 26; 281(5380). PMID: 9712583
Highly Cited.
Results of a Phase I study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children with Stage 4 neuroblastoma.
Denise A Caruso, Lisa M Orme, +5 authors, David M Ashley.
Cancer, 2005 Feb 05; 103(6). PMID: 15693021
Inflammatory dendritic cells in mice and humans.
Elodie Segura, Sebastian Amigorena.
Trends Immunol, 2013 Jul 09; 34(9). PMID: 23831267
Highly Cited. Review.
The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.
John-Demian Sauer, Katia Sotelo-Troha, +8 authors, Russell E Vance.
Infect Immun, 2010 Nov 26; 79(2). PMID: 21098106    Free PMC article.
Highly Cited.
Aglycosylation of human IgG1 and IgG3 monoclonal antibodies can eliminate recognition by human cells expressing Fc gamma RI and/or Fc gamma RII receptors.
M R Walker, J Lund, K M Thompson, R Jefferis.
Biochem J, 1989 Apr 15; 259(2). PMID: 2524188    Free PMC article.
Is There Still Room for Cancer Vaccines at the Era of Checkpoint Inhibitors.
Soumaya Karaki, Marie Anson, +4 authors, Eric Tartour.
Vaccines (Basel), 2016 Nov 10; 4(4). PMID: 27827885    Free PMC article.
Review.
Human Blood CD1c+ Dendritic Cells Encompass CD5high and CD5low Subsets That Differ Significantly in Phenotype, Gene Expression, and Functions.
Xiangyun Yin, Haisheng Yu, +9 authors, Liguo Zhang.
J Immunol, 2017 Jan 15; 198(4). PMID: 28087664
Taking dendritic cells into medicine.
Ralph M Steinman, Jacques Banchereau.
Nature, 2007 Sep 28; 449(7161). PMID: 17898760
Highly Cited. Review.
PD-L2 is a second ligand for PD-1 and inhibits T cell activation.
Y Latchman, C R Wood, +18 authors, G J Freeman.
Nat Immunol, 2001 Feb 27; 2(3). PMID: 11224527
Highly Cited.
The Structural Role of Antibody N-Glycosylation in Receptor Interactions.
Ganesh P Subedi, Adam W Barb.
Structure, 2015 Jul 28; 23(9). PMID: 26211613    Free PMC article.
Highly Cited.
Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant.
Sylvia Adams, David W O'Neill, +21 authors, Nina Bhardwaj.
J Immunol, 2008 Jun 21; 181(1). PMID: 18566444    Free PMC article.
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement.
P S Linsley, J Bradshaw, +3 authors, R S Mittler.
Immunity, 1996 Jun 01; 4(6). PMID: 8673700
Highly Cited.
Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses.
Botond Z Igyártó, Krystal Haley, +8 authors, Daniel H Kaplan.
Immunity, 2011 Jul 26; 35(2). PMID: 21782478    Free PMC article.
Highly Cited.
RNA recognition by human TLR8 can lead to autoimmune inflammation.
Cristiana Guiducci, Mei Gong, +9 authors, Franck J Barrat.
J Exp Med, 2013 Nov 28; 210(13). PMID: 24277153    Free PMC article.
The Consequences of Multiple Simultaneous C-Type Lectin-Ligand Interactions: DCIR Alters the Endo-Lysosomal Routing of DC-SIGN.
Juan J García-Vallejo, Karien Bloem, +3 authors, Yvette van Kooyk.
Front Immunol, 2015 Mar 26; 6. PMID: 25806031    Free PMC article.
Plasmacytoid Dendritic Cells: Development, Regulation, and Function.
Boris Reizis.
Immunity, 2019 Jan 17; 50(1). PMID: 30650380    Free PMC article.
Highly Cited. Review.
CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics.
P A van der Merwe, D L Bodian, +2 authors, S J Davis.
J Exp Med, 1997 Feb 03; 185(3). PMID: 9053440    Free PMC article.
Highly Cited.
Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo.
D Hawiger, K Inaba, +6 authors, M C Nussenzweig.
J Exp Med, 2001 Sep 19; 194(6). PMID: 11560993    Free PMC article.
Highly Cited.
CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients.
Chrysoula I Liakou, Ashish Kamat, +5 authors, Padmanee Sharma.
Proc Natl Acad Sci U S A, 2008 Sep 27; 105(39). PMID: 18818309    Free PMC article.
Highly Cited.
Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.
Simon Read, Rebecca Greenwald, +5 authors, Fiona Powrie.
J Immunol, 2006 Sep 20; 177(7). PMID: 16982872    Free PMC article.
Highly Cited.
Langerhans cells derived from genetically modified human CD34+ hemopoietic progenitors are more potent than peptide-pulsed Langerhans cells for inducing antigen-specific CD8+ cytolytic T lymphocyte responses.
Jianda Yuan, Jean-Baptiste Latouche, +4 authors, James W Young.
J Immunol, 2005 Jan 07; 174(2). PMID: 15634896
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa, Glen N Barber.
Nature, 2008 Aug 30; 455(7213). PMID: 18724357    Free PMC article.
Highly Cited.
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells.
Loise M Francisco, Victor H Salinas, +4 authors, Arlene H Sharpe.
J Exp Med, 2009 Dec 17; 206(13). PMID: 20008522    Free PMC article.
Highly Cited.
Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
A Alicia Koblansky, Dragana Jankovic, +7 authors, Sankar Ghosh.
Immunity, 2012 Dec 19; 38(1). PMID: 23246311    Free PMC article.
Highly Cited.
Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells.
Alfonso R Sánchez-Paulete, Francisco J Cueto, +9 authors, Ignacio Melero.
Cancer Discov, 2015 Oct 24; 6(1). PMID: 26493961    Free PMC article.
Highly Cited.
Interferon Lambda Upregulates IDO1 Expression in Respiratory Epithelial Cells After Influenza Virus Infection.
Julie M Fox, Jackelyn M Crabtree, +2 authors, Ralph A Tripp.
J Interferon Cytokine Res, 2015 Mar 11; 35(7). PMID: 25756191    Free PMC article.
Two-step binding mechanism for T-cell receptor recognition of peptide MHC.
Lawren C Wu, Delphine S Tuot, +2 authors, Mark M Davis.
Nature, 2002 Aug 02; 418(6897). PMID: 12152083
IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection.
Douglas C Wilson, Suzanne Matthews, George S Yap.
J Immunol, 2008 Apr 22; 180(9). PMID: 18424713
Humanization of antibodies using heavy chain complementarity-determining region 3 grafting coupled with in vitro somatic hypermutation.
Peter M Bowers, Tamlyn Y Neben, +11 authors, David J King.
J Biol Chem, 2013 Jan 29; 288(11). PMID: 23355464    Free PMC article.
Immune signaling by RIG-I-like receptors.
Yueh-Ming Loo, Michael Gale.
Immunity, 2011 May 28; 34(5). PMID: 21616437    Free PMC article.
Highly Cited. Review.
Safety and immunogenicity of CPG 7909 injection as an adjuvant to Fluarix influenza vaccine.
C L Cooper, H L Davis, +8 authors, D W Cameron.
Vaccine, 2004 Aug 07; 22(23-24). PMID: 15297066
Requirement for CD4 T cell help in generating functional CD8 T cell memory.
Devon J Shedlock, Hao Shen.
Science, 2003 Apr 12; 300(5617). PMID: 12690201
Highly Cited.
Results of a phase 1 study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children and young adults with brain cancer.
Denise A Caruso, Lisa M Orme, +7 authors, David M Ashley.
Neuro Oncol, 2004 Jul 29; 6(3). PMID: 15279716    Free PMC article.
CD40-targeted adenoviral gene transfer to dendritic cells through the use of a novel bispecific single-chain Fv antibody enhances cytotoxic T cell activation.
Joana G Brandão, Rik J Scheper, +7 authors, Tanja D de Gruijl.
Vaccine, 2003 May 15; 21(19-20). PMID: 12744857
Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory.
Luigia Pace, Andy Tempez, +5 authors, Sebastian Amigorena.
Science, 2012 Nov 01; 338(6106). PMID: 23112334
C-type lectins in immunity and homeostasis.
Gordon D Brown, Janet A Willment, Lauren Whitehead.
Nat Rev Immunol, 2018 Mar 28; 18(6). PMID: 29581532
Highly Cited. Review.
By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation.
Ivan Zanoni, Yunhao Tan, +2 authors, Jonathan C Kagan.
Immunity, 2017 Oct 19; 47(4). PMID: 29045901    Free PMC article.
Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide.
C J Kirschning, H Wesche, T Merrill Ayres, M Rothe.
J Exp Med, 1998 Dec 08; 188(11). PMID: 9841923    Free PMC article.
Highly Cited.
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.
A Poltorak, X He, +11 authors, B Beutler.
Science, 1998 Dec 16; 282(5396). PMID: 9851930
Highly Cited.
The extra domain A of fibronectin activates Toll-like receptor 4.
Y Okamura, M Watari, +5 authors, J F Strauss.
J Biol Chem, 2001 Jan 21; 276(13). PMID: 11150311
Highly Cited.
OX40 ligand shuts down IL-10-producing regulatory T cells.
Tomoki Ito, Yui-Hsi Wang, +5 authors, Yong-Jun Liu.
Proc Natl Acad Sci U S A, 2006 Aug 23; 103(35). PMID: 16924108    Free PMC article.
A Specific, Glycomimetic Langerin Ligand for Human Langerhans Cell Targeting.
Eike-Christian Wamhoff, Jessica Schulze, +12 authors, Christoph Rademacher.
ACS Cent Sci, 2019 May 30; 5(5). PMID: 31139717    Free PMC article.
STING is a direct innate immune sensor of cyclic di-GMP.
Dara L Burdette, Kathryn M Monroe, +5 authors, Russell E Vance.
Nature, 2011 Sep 29; 478(7370). PMID: 21947006    Free PMC article.
Highly Cited.
Inflammasomes: mechanism of assembly, regulation and signalling.
Petr Broz, Vishva M Dixit.
Nat Rev Immunol, 2016 Jun 14; 16(7). PMID: 27291964
Highly Cited. Review.
Innate immune pattern recognition: a cell biological perspective.
Sky W Brubaker, Kevin S Bonham, Ivan Zanoni, Jonathan C Kagan.
Annu Rev Immunol, 2015 Jan 13; 33. PMID: 25581309    Free PMC article.
Highly Cited. Review.
Triggering of NF-κB in cytokine-matured human DCs generates superior DCs for T-cell priming in cancer immunotherapy.
Isabell A Pfeiffer, Stefanie Hoyer, +6 authors, Jan Dörrie.
Eur J Immunol, 2014 Aug 08; 44(11). PMID: 25100611
Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation.
Bettina L Lee, Irma B Stowe, +7 authors, Nobuhiko Kayagaki.
J Exp Med, 2018 Aug 24; 215(9). PMID: 30135078    Free PMC article.
T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions.
S P Schoenberger, R E Toes, +2 authors, C J Melief.
Nature, 1998 Jun 12; 393(6684). PMID: 9624005
Highly Cited.
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.
Yuan He, Melody Y Zeng, +2 authors, Gabriel Núñez.
Nature, 2016 Jan 28; 530(7590). PMID: 26814970    Free PMC article.
Highly Cited.
STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells.
Jared Klarquist, Cassandra M Hennies, +3 authors, Edith M Janssen.
J Immunol, 2014 Nov 12; 193(12). PMID: 25385820    Free PMC article.
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity.
Stefani Spranger, Riyue Bao, Thomas F Gajewski.
Nature, 2015 May 15; 523(7559). PMID: 25970248
Highly Cited.
Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation.
Yves Delneste, Giovanni Magistrelli, +8 authors, Pascale Jeannin.
Immunity, 2002 Oct 02; 17(3). PMID: 12354387
Highly Cited.
Systemic Immunity Is Required for Effective Cancer Immunotherapy.
Matthew H Spitzer, Yaron Carmi, +10 authors, Edgar G Engleman.
Cell, 2017 Jan 24; 168(3). PMID: 28111070    Free PMC article.
Highly Cited.
A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc Receptors.
Daniela Kao, Heike Danzer, +6 authors, Falk Nimmerjahn.
Cell Rep, 2015 Dec 17; 13(11). PMID: 26670049
Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance.
Laura Bonifaz, David Bonnyay, +3 authors, Ralph M Steinman.
J Exp Med, 2002 Dec 18; 196(12). PMID: 12486105    Free PMC article.
Highly Cited.
Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12.
Bart Everts, Roxane Tussiwand, +9 authors, Edward J Pearce.
J Exp Med, 2015 Dec 30; 213(1). PMID: 26712805    Free PMC article.
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Omar S Qureshi, Yong Zheng, +12 authors, David M Sansom.
Science, 2011 Apr 09; 332(6029). PMID: 21474713    Free PMC article.
Highly Cited.
Different populations of CD11b+ dendritic cells drive Th2 responses in the small intestine and colon.
Johannes U Mayer, Mimoza Demiri, +3 authors, Simon W Milling.
Nat Commun, 2017 Jun 10; 8. PMID: 28598427    Free PMC article.
Highly Cited.
Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation.
Qifan Zhu, Si Ming Man, +4 authors, Thirumala-Devi Kanneganti.
J Immunol, 2014 Oct 17; 193(10). PMID: 25320273    Free PMC article.
Efficient generation of CD34+ progenitor-derived dendritic cells from G-CSF-mobilized peripheral mononuclear cells does not require hematopoietic stem cell enrichment.
Sophie Paczesny, Yin-Ping Li, +6 authors, Assia Eljaafari.
J Leukoc Biol, 2007 Jan 19; 81(4). PMID: 17229904
Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR.
Barbara Valzasina, Cristiana Guiducci, +3 authors, Mario P Colombo.
Blood, 2004 Dec 14; 105(7). PMID: 15591118
Highly Cited.
CD27 is required for generation and long-term maintenance of T cell immunity.
J Hendriks, L A Gravestein, +3 authors, J Borst.
Nat Immunol, 2001 Mar 23; 1(5). PMID: 11062504
Highly Cited.
Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses.
Silvia B Boscardin, Julius C R Hafalla, +8 authors, Michel C Nussenzweig.
J Exp Med, 2006 Mar 01; 203(3). PMID: 16505139    Free PMC article.
Highly Cited.
CD4+ T cell help in cancer immunology and immunotherapy.
Jannie Borst, Tomasz Ahrends, +2 authors, Wolfgang Kastenmüller.
Nat Rev Immunol, 2018 Jul 31; 18(10). PMID: 30057419
Highly Cited. Review.
Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR.
A L Gurney, S A Marsters, +13 authors, A Ashkenazi.
Curr Biol, 1999 Mar 13; 9(4). PMID: 10074428
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.
Chrysothemis C Brown, Herman Gudjonson, +9 authors, Alexander Y Rudensky.
Cell, 2019 Nov 02; 179(4). PMID: 31668803    Free PMC article.
Highly Cited.
The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway.
Ramunas M Vabulas, Sibylla Braedel, +8 authors, Hansjorg Schild.
J Biol Chem, 2002 Mar 26; 277(23). PMID: 11912201
Highly Cited.
Immunoregulatory functions of VISTA.
Elizabeth C Nowak, J Louise Lines, +7 authors, Randolph J Noelle.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258694    Free PMC article.
Highly Cited. Review.
Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.
Alexzander Asea, Michael Rehli, +5 authors, Stuart K Calderwood.
J Biol Chem, 2002 Feb 12; 277(17). PMID: 11836257
Highly Cited.
Innate sensing of self and non-self RNAs by Toll-like receptors.
Mouldy Sioud.
Trends Mol Med, 2006 Mar 15; 12(4). PMID: 16530484
Review.
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4.
L E Marengère, P Waterhouse, +3 authors, T W Mak.
Science, 1996 May 24; 272(5265). PMID: 8638161
Highly Cited.
Intestinal CD103+CD11b+ cDC2 Conventional Dendritic Cells Are Required for Primary CD4+ T and B Cell Responses to Soluble Flagellin.
Adriana Flores-Langarica, Charlotte Cook, +12 authors, Adam F Cunningham.
Front Immunol, 2018 Nov 06; 9. PMID: 30386346    Free PMC article.
Modulation of tryptophan catabolism by regulatory T cells.
Francesca Fallarino, Ursula Grohmann, +7 authors, Paolo Puccetti.
Nat Immunol, 2003 Oct 28; 4(12). PMID: 14578884
Highly Cited.
OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells.
P R Rogers, J Song, +2 authors, M Croft.
Immunity, 2001 Sep 25; 15(3). PMID: 11567634
Highly Cited.
NOD-like receptors: major players (and targets) in the interface between innate immunity and cancer.
Fernando J Velloso, Marina Trombetta-Lima, +2 authors, Ricardo G Correa.
Biosci Rep, 2019 Mar 07; 39(4). PMID: 30837326    Free PMC article.
Review.
Targeting dendritic cells--why bother?
Martin Kreutz, Paul J Tacken, Carl G Figdor.
Blood, 2013 Feb 08; 121(15). PMID: 23390195
The diverse functions of the PD1 inhibitory pathway.
Arlene H Sharpe, Kristen E Pauken.
Nat Rev Immunol, 2017 Oct 11; 18(3). PMID: 28990585
Highly Cited. Review.
Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells.
Sandra Tuyaerts, Sonja Van Meirvenne, +6 authors, Joeri L Aerts.
J Leukoc Biol, 2007 Apr 24; 82(1). PMID: 17449724
Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling.
Scott H Robbins, Thierry Walzer, +11 authors, Marc Dalod.
Genome Biol, 2008 Jan 26; 9(1). PMID: 18218067    Free PMC article.
Highly Cited.
4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection.
Vaiva Vezys, Pablo Penaloza-MacMaster, +5 authors, Rafi Ahmed.
J Immunol, 2011 Jul 12; 187(4). PMID: 21742975    Free PMC article.
TLR signaling by tumor and immune cells: a double-edged sword.
B Huang, J Zhao, +2 authors, H Xiong.
Oncogene, 2008 Jan 08; 27(2). PMID: 18176603
Highly Cited. Review.
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.
Takeshi Kondo, Junya Kobayashi, +6 authors, Taro Kawai.
Proc Natl Acad Sci U S A, 2013 Feb 08; 110(8). PMID: 23388631    Free PMC article.
Highly Cited.
IFN-α enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing.
Francesca Spadaro, Caterina Lapenta, +5 authors, Maria Ferrantini.
Blood, 2011 Dec 21; 119(6). PMID: 22184405
The STING pathway and the T cell-inflamed tumor microenvironment.
Seng-Ryong Woo, Leticia Corrales, Thomas F Gajewski.
Trends Immunol, 2015 Mar 12; 36(4). PMID: 25758021    Free PMC article.
Highly Cited. Review.
A minimal RNA ligand for potent RIG-I activation in living mice.
Melissa M Linehan, Thayne H Dickey, +4 authors, Anna M Pyle.
Sci Adv, 2018 Mar 02; 4(2). PMID: 29492454    Free PMC article.
Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses.
Masashi Watanabe, Yuri Takagi, +7 authors, Ryo Abe.
J Immunol, 2008 Apr 09; 180(8). PMID: 18390703
Targeting CpG oligonucleotides to the lymph node by nanoparticles elicits efficient antitumoral immunity.
Carole Bourquin, David Anz, +10 authors, Stefan Endres.
J Immunol, 2008 Aug 21; 181(5). PMID: 18713969
Selection of an antibody library identifies a pathway to induce immunity by targeting CD36 on steady-state CD8 alpha+ dendritic cells.
Elisa Tagliani, Pierre Guermonprez, +5 authors, Oscar R Burrone.
J Immunol, 2008 Feb 23; 180(5). PMID: 18292544
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Jun Liu, Ying Yuan, +8 authors, Li Wang.
Proc Natl Acad Sci U S A, 2015 May 13; 112(21). PMID: 25964334    Free PMC article.
Highly Cited.
Expansion of melanoma-specific cytolytic CD8+ T cell precursors in patients with metastatic melanoma vaccinated with CD34+ progenitor-derived dendritic cells.
Sophie Paczesny, Jacques Banchereau, +3 authors, A Karolina Palucka.
J Exp Med, 2004 Jun 03; 199(11). PMID: 15173207    Free PMC article.
Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1.
Naomi N Hunder, Herschel Wallen, +7 authors, Cassian Yee.
N Engl J Med, 2008 Jun 21; 358(25). PMID: 18565862    Free PMC article.
Highly Cited.
Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state.
Florent Ginhoux, Matthew P Collin, +10 authors, Miriam Merad.
J Exp Med, 2007 Dec 19; 204(13). PMID: 18086862    Free PMC article.
Highly Cited.
Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.
Christina E Zielinski, Federico Mele, +6 authors, Federica Sallusto.
Nature, 2012 Apr 03; 484(7395). PMID: 22466287
Highly Cited.
Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype.
Mireille H Lahoud, Fatma Ahmet, +13 authors, Irina Caminschi.
J Immunol, 2011 Jun 17; 187(2). PMID: 21677141
LOX-1 as a natural IFN-alpha-mediated signal for apoptotic cell uptake and antigen presentation in dendritic cells.
Stefania Parlato, Giulia Romagnoli, +8 authors, Filippo Belardelli.
Blood, 2009 Dec 17; 115(8). PMID: 20009034
Phase I/II trial of dendritic cell-based active cellular immunotherapy with DCVAC/PCa in patients with rising PSA after primary prostatectomy or salvage radiotherapy for the treatment of prostate cancer.
Jitka Fucikova, Michal Podrazil, +13 authors, Jirina Bartunkova.
Cancer Immunol Immunother, 2017 Sep 28; 67(1). PMID: 28948333
Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation.
Xin Cai, Jueqi Chen, +4 authors, Zhijian J Chen.
Cell, 2014 Mar 19; 156(6). PMID: 24630723    Free PMC article.
Highly Cited.
TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis.
Tatsukata Kawagoe, Osamu Takeuchi, +4 authors, Shizuo Akira.
Nat Immunol, 2009 Aug 12; 10(9). PMID: 19668221    Free PMC article.
TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages.
Michael P Gantier, Stephen Tong, +4 authors, Bryan R G Williams.
J Immunol, 2008 Feb 06; 180(4). PMID: 18250417
CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells.
Sandrine Henri, Lionel Franz Poulin, +8 authors, Bernard Malissen.
J Exp Med, 2009 Dec 30; 207(1). PMID: 20038600    Free PMC article.
Highly Cited.
Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells.
F J Hsu, C Benike, +5 authors, R Levy.
Nat Med, 1996 Jan 01; 2(1). PMID: 8564842
Highly Cited.
Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health status.
Diana Mittag, Anna I Proietto, +5 authors, Leonard C Harrison.
J Immunol, 2011 Apr 26; 186(11). PMID: 21515786
Highly Cited.
MyD88 and its divergent toll in carcinogenesis.
Rosalba Salcedo, Christophe Cataisson, +2 authors, Giorgio Trinchieri.
Trends Immunol, 2013 May 11; 34(8). PMID: 23660392    Free PMC article.
Review.
A distinct subset of plasmacytoid dendritic cells induces activation and differentiation of B and T lymphocytes.
Hong Zhang, Josh D Gregorio, +6 authors, Edgar G Engleman.
Proc Natl Acad Sci U S A, 2017 Feb 09; 114(8). PMID: 28167780    Free PMC article.
NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control.
Jan P Böttcher, Eduardo Bonavita, +7 authors, Caetano Reis e Sousa.
Cell, 2018 Feb 13; 172(5). PMID: 29429633    Free PMC article.
Highly Cited.
Cloning and characterization of GITR ligand.
J D Kim, B K Choi, +6 authors, B S Kwon.
Genes Immun, 2003 Dec 04; 4(8). PMID: 14647196
Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes.
Lynn E Macdonald, Margaret Karow, +9 authors, Andrew J Murphy.
Proc Natl Acad Sci U S A, 2014 Apr 08; 111(14). PMID: 24706858    Free PMC article.
Highly Cited.
The future of immune checkpoint therapy.
Padmanee Sharma, James P Allison.
Science, 2015 Apr 04; 348(6230). PMID: 25838373
Highly Cited. Review.
Newly described pattern recognition receptors team up against intracellular pathogens.
Petr Broz, Denise M Monack.
Nat Rev Immunol, 2013 Jul 13; 13(8). PMID: 23846113
Highly Cited. Review.
Glucocorticoid-induced TNFR-related (GITR) protein and its ligand in antitumor immunity: functional role and therapeutic modulation.
Theresa Placke, Hans-Georg Kopp, Helmut Rainer Salih.
Clin Dev Immunol, 2010 Oct 12; 2010. PMID: 20936139    Free PMC article.
Review.
Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome.
Dacquin M Kasumba, Nathalie Grandvaux.
Trends Pharmacol Sci, 2019 Jan 05; 40(2). PMID: 30606502    Free PMC article.
Review.
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.
Rebecca S McHugh, Matthew J Whitters, +4 authors, Michael C Byrne.
Immunity, 2002 Mar 01; 16(2). PMID: 11869690
Highly Cited.
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
H D Brightbill, D H Libraty, +11 authors, R L Modlin.
Science, 1999 Jul 31; 285(5428). PMID: 10426995
Highly Cited.
Enhancement of antitumor immunity by CTLA-4 blockade.
D R Leach, M F Krummel, J P Allison.
Science, 1996 Mar 22; 271(5256). PMID: 8596936
Highly Cited.
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells.
Roza Nurieva, Xuexian O Yang, +8 authors, Chen Dong.
Nature, 2007 Jun 22; 448(7152). PMID: 17581589
Highly Cited.
PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity.
Vikram R Juneja, Kathleen A McGuire, +5 authors, Arlene H Sharpe.
J Exp Med, 2017 Mar 18; 214(4). PMID: 28302645    Free PMC article.
Highly Cited.
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
Ivaylo I Ivanov, Brent S McKenzie, +5 authors, Dan R Littman.
Cell, 2006 Sep 23; 126(6). PMID: 16990136
Highly Cited.
Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection.
Alison Crawford, Jill M Angelosanto, +4 authors, E John Wherry.
Immunity, 2014 Feb 18; 40(2). PMID: 24530057    Free PMC article.
Highly Cited.
Maturation of Monocyte-Derived DCs Leads to Increased Cellular Stiffness, Higher Membrane Fluidity, and Changed Lipid Composition.
Jennifer J Lühr, Nils Alex, +14 authors, Diana Dudziak.
Front Immunol, 2020 Dec 18; 11. PMID: 33329576    Free PMC article.
Complement-Opsonized Nano-Carriers Are Bound by Dendritic Cells (DC) via Complement Receptor (CR)3, and by B Cell Subpopulations via CR-1/2, and Affect the Activation of DC and B-1 Cells.
Monika Bednarczyk, Carolina Medina-Montano, +11 authors, Matthias Bros.
Int J Mol Sci, 2021 Apr 04; 22(6). PMID: 33799879    Free PMC article.
Characterization and Manipulation of the Crosstalk Between Dendritic and Natural Killer Cells Within the Tumor Microenvironment.
Benedikt Jacobs, Veronika Gebel, +4 authors, Evelyn Ullrich.
Front Immunol, 2021 Jun 01; 12. PMID: 34054844    Free PMC article.
Review.
Toll-Like Receptor-Based Strategies for Cancer Immunotherapy.
Saghar Pahlavanneshan, Ali Sayadmanesh, Hamidreza Ebrahimiyan, Mohsen Basiri.
J Immunol Res, 2021 Jun 15; 2021. PMID: 34124272    Free PMC article.
Review.
Large-Sized Graphene Oxide Nanosheets Increase DC-T-Cell Synaptic Contact and the Efficacy of DC Vaccines against SARS-CoV-2.
Qianqian Zhou, Hongjing Gu, +10 authors, Linsheng Zhan.
Adv Mater, 2021 Aug 17; 33(40). PMID: 34396603    Free PMC article.
BRAF and MEK Inhibitors Affect Dendritic-Cell Maturation and T-Cell Stimulation.
Stefanie Hoyer, Valentina Eberlein, +4 authors, Jan Dörrie.
Int J Mol Sci, 2021 Nov 14; 22(21). PMID: 34769379    Free PMC article.
Incorporation of Toll-Like Receptor Ligands and Inflammasome Stimuli in GM3 Liposomes to Induce Dendritic Cell Maturation and T Cell Responses.
Maarten K Nijen Twilhaar, Lucas Czentner, +10 authors, Joke M M den Haan.
Front Immunol, 2022 Mar 08; 13. PMID: 35251040    Free PMC article.
Molecular Mechanisms of Anti-Neoplastic and Immune Stimulatory Properties of Oncolytic Newcastle Disease Virus.
Volker Schirrmacher.
Biomedicines, 2022 Mar 26; 10(3). PMID: 35327364    Free PMC article.
Review.