. 2020 Jul; 12(7):.
doi: 10.3390/pharmaceutics12070663.

Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy

Lukas Amon 1 Lukas Hatscher 1 Lukas Heger 1 Diana Dudziak 1 Christian H K Lehmann 1 
  • PMID: 32674488
  •     781 References
  •     8 citations


The onset of checkpoint inhibition revolutionized the treatment of cancer. However, studies from the last decade suggested that the sole enhancement of T cell functionality might not suffice to fight malignancies in all individuals. Dendritic cells (DCs) are not only part of the innate immune system, but also generals of adaptive immunity and they orchestrate the de novo induction of tolerogenic and immunogenic T cell responses. Thus, combinatorial approaches addressing DCs and T cells in parallel represent an attractive strategy to achieve higher response rates across patients. However, this requires profound knowledge about the dynamic interplay of DCs, T cells, other immune and tumor cells. Here, we summarize the DC subsets present in mice and men and highlight conserved and divergent characteristics between different subsets and species. Thereby, we supply a resource of the molecular players involved in key functional features of DCs ranging from their sentinel function, the translation of the sensed environment at the DC:T cell interface to the resulting specialized T cell effector modules, as well as the influence of the tumor microenvironment on the DC function. As of today, mostly monocyte derived dendritic cells (moDCs) are used in autologous cell therapies after tumor antigen loading. While showing encouraging results in a fraction of patients, the overall clinical response rate is still not optimal. By disentangling the general aspects of DC biology, we provide rationales for the design of next generation DC vaccines enabling to exploit and manipulate the described pathways for the purpose of cancer immunotherapy in vivo. Finally, we discuss how DC-based vaccines might synergize with checkpoint inhibition in the treatment of malignant diseases.

Keywords: T cells; antigen targeting; cancer therapy; checkpoint inhibition; dendritic cells; pattern recognition receptors; tumor microenvironment; vaccination.

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Sci Signal, 2013 Jan 17; 6(258). PMID: 23322906    Free PMC article.
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Douglas Hanahan, Robert A Weinberg.
Cell, 2011 Mar 08; 144(5). PMID: 21376230
Highly Cited. Review.
IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17.
Curtis J Henry, David A Ornelles, +2 authors, Elizabeth M Hiltbold.
J Immunol, 2008 Dec 04; 181(12). PMID: 19050277    Free PMC article.
PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+ CD25(Hi) regulatory T cells.
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Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells.
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Blood, 2002 Oct 18; 100(9). PMID: 12384430
STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation.
Henrique Lemos, Eslam Mohamed, +5 authors, Andrew L Mellor.
Cancer Res, 2016 Mar 12; 76(8). PMID: 26964621    Free PMC article.
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Olivier P Joffre, Elodie Segura, Ariel Savina, Sebastian Amigorena.
Nat Rev Immunol, 2012 Jul 14; 12(8). PMID: 22790179
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The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8.
Prafullakumar Tailor, Tomohiko Tamura, +5 authors, Keiko Ozato.
Immunity, 2007 Aug 19; 27(2). PMID: 17702615    Free PMC article.
Type I interferon is selectively required by dendritic cells for immune rejection of tumors.
Mark S Diamond, Michelle Kinder, +9 authors, Robert D Schreiber.
J Exp Med, 2011 Sep 21; 208(10). PMID: 21930769    Free PMC article.
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An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases.
Yang Liu, William N Crowe, +4 authors, Dawen Zhao.
Nat Commun, 2019 Nov 11; 10(1). PMID: 31704921    Free PMC article.
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Annu Rev Immunol, 2013 Mar 23; 31. PMID: 23516985    Free PMC article.
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PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation.
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Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells.
Genc Basha, Tatiana I Novobrantseva, +12 authors, Pieter R Cullis.
Mol Ther, 2011 Oct 06; 19(12). PMID: 21971424    Free PMC article.
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Allergo J Int, 2018 Dec 14; 27(8). PMID: 30546997    Free PMC article.
Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells.
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Immunity, 2019 Sep 03; 51(3). PMID: 31474513
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Concurrent interaction of DCs with CD4(+) and CD8(+) T cells improves secondary CTL expansion: It takes three to tango.
Stefanie Hoyer, Sabrina Prommersberger, +4 authors, Niels Schaft.
Eur J Immunol, 2014 Sep 12; 44(12). PMID: 25211552
XCR1+ dendritic cells promote memory CD8+ T cell recall upon secondary infections with Listeria monocytogenes or certain viruses.
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J Exp Med, 2015 Dec 24; 213(1). PMID: 26694969    Free PMC article.
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Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437871    Free PMC article.
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Nicholas M Provine, Rafael A Larocca, +10 authors, Dan H Barouch.
J Immunol, 2016 Jul 28; 197(5). PMID: 27448585    Free PMC article.
Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression.
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J Immunol, 2004 May 07; 172(10). PMID: 15128759
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Mol Immunol, 2020 Mar 03; 120. PMID: 32114182
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Nat Rev Immunol, 2010 Mar 26; 10(4). PMID: 20336151    Free PMC article.
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Stimulation of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) induces inflammatory activation of microglia in culture.
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J Neurosci Res, 2010 Feb 18; 88(10). PMID: 20162721
Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses.
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Eur J Immunol, 2003 Sep 30; 33(10). PMID: 14515254
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Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin.
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J Neurosci, 2009 Apr 03; 29(13). PMID: 19339614    Free PMC article.
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Elodie Segura, Eugene Kapp, +6 authors, José A Villadangos.
Mol Immunol, 2010 Mar 30; 47(9). PMID: 20347150
Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer.
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Gerold Schuler.
Eur J Immunol, 2010 Sep 21; 40(8). PMID: 20853498
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Nat Med, 1999 Jul 08; 5(7). PMID: 10395322
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Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele.
Matija Hedl, Amit Lahiri, +2 authors, Clara Abraham.
Immunity, 2014 May 20; 40(5). PMID: 24837102    Free PMC article.
Dendritic cells: a critical player in cancer therapy?
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J Immunother, 2008 Oct 04; 31(9). PMID: 18833008    Free PMC article.
CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities.
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CD154 and IL-2 signaling of CD4+ T cells play a critical role in multiple phases of CD8+ CTL responses following adenovirus vaccination.
Channakeshava Sokke Umeshappa, Roopa Hebbandi Nanjundappa, +4 authors, Jim Xiang.
PLoS One, 2012 Oct 17; 7(10). PMID: 23071696    Free PMC article.
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Immunity, 2005 Jul 26; 23(1). PMID: 16039576
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Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+T cell recognition.
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J Immunol, 2012 Dec 12; 190(1). PMID: 23225887    Free PMC article.
Targeting of cancer neoantigens with donor-derived T cell receptor repertoires.
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Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.
Y Agata, A Kawasaki, +4 authors, T Honjo.
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BTLA-Expressing Dendritic Cells in Patients With Tuberculosis Exhibit Reduced Production of IL-12/IFN-α and Increased Production of IL-4 and TGF-β, Favoring Th2 and Foxp3+ Treg Polarization.
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Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia.
Gemma G Kenter, Marij J P Welters, +12 authors, Cornelis J M Melief.
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J Immunol, 2001 Feb 24; 166(5). PMID: 11207245
Cytokines regulate the capacity of CD8alpha(+) and CD8alpha(-) dendritic cells to prime Th1/Th2 cells in vivo.
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J Immunol, 2001 Oct 10; 167(8). PMID: 11591758
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J Immunol, 2009 Nov 18; 183(11). PMID: 19917701
A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells.
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J Immunol, 2004 Apr 07; 172(8). PMID: 15067049
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Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade.
Yoshiko Iwai, Masayoshi Ishida, +3 authors, Nagahiro Minato.
Proc Natl Acad Sci U S A, 2002 Sep 10; 99(19). PMID: 12218188    Free PMC article.
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Pattern recognition receptors and inflammation.
Osamu Takeuchi, Shizuo Akira.
Cell, 2010 Mar 23; 140(6). PMID: 20303872
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J Immunol, 2011 Dec 08; 188(2). PMID: 22147766    Free PMC article.
Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells.
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Immunity, 2008 Apr 05; 28(4). PMID: 18387832
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J Exp Med, 2016 Apr 14; 213(5). PMID: 27069117    Free PMC article.
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Eur J Immunol, 2006 Aug 19; 36(9). PMID: 16917960
Functional RNA delivery targeted to dendritic cells by synthetic nanoparticles.
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Nat Rev Genet, 2008 Jan 30; 9(3). PMID: 18227810
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Blood, 2007 Jun 19; 110(7). PMID: 17575071    Free PMC article.
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An immunogenic personal neoantigen vaccine for patients with melanoma.
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S Y Tseng, M Otsuji, +7 authors, H Tsuchiya.
J Exp Med, 2001 Apr 03; 193(7). PMID: 11283156    Free PMC article.
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Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice.
Bei Wang, Neeha Zaidi, +4 authors, Ralph M Steinman.
Breast Cancer Res, 2012 Mar 09; 14(2). PMID: 22397502    Free PMC article.
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Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics.
Simon Zenke, Margriet M Palm, +10 authors, Jan C Rohr.
Immunity, 2020 Feb 13; 52(2). PMID: 32049052
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Immunity, 2013 May 28; 38(5). PMID: 23706669    Free PMC article.
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Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing.
Mahesh Yadav, Suchit Jhunjhunwala, +11 authors, Lélia Delamarre.
Nature, 2014 Nov 28; 515(7528). PMID: 25428506
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Mobilization of dendritic cell precursors in patients with cancer by flt3 ligand allows the generation of higher yields of cultured dendritic cells.
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J Immunother, 2002 May 10; 25(3). PMID: 12000870    Free PMC article.
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.
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J Biol Chem, 1999 Nov 24; 274(47). PMID: 10559223
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Neutralizing tumor-promoting chronic inflammation: a magic bullet?
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TLR11 activation of dendritic cells by a protozoan profilin-like protein.
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PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.
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Immunity, 2016 Oct 30; 45(5). PMID: 27793593    Free PMC article.
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Nat Rev Immunol, 2014 Jul 26; 14(8). PMID: 25060580
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The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice.
Fang Ma, Jianhua Zhang, Jian Zhang, Cai Zhang.
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J Immunol, 2008 Nov 05; 181(10). PMID: 18981112    Free PMC article.
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Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.
Florian Heil, Hiroaki Hemmi, +6 authors, Stefan Bauer.
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LGP2 binds to PACT to regulate RIG-I- and MDA5-mediated antiviral responses.
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Sci Signal, 2019 Oct 03; 12(601). PMID: 31575732
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J Immunol, 2007 Jan 24; 178(3). PMID: 17237405
Regulation of lung injury and repair by Toll-like receptors and hyaluronan.
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Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity.
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Blood, 2011 Oct 05; 118(26). PMID: 21967977
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A phase I trial of tumor lysate-pulsed dendritic cells in the treatment of advanced cancer.
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Clin Cancer Res, 2002 Apr 12; 8(4). PMID: 11948109
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.
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A prophylactic hepatitis B vaccine with a novel adjuvant system.
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Discrimination of bacterial lipoproteins by Toll-like receptor 6.
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CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion.
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Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.
Christian A Luber, Jürgen Cox, +8 authors, Matthias Mann.
Immunity, 2010 Feb 23; 32(2). PMID: 20171123
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Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors.
Alexandra-Chloé Villani, Rahul Satija, +21 authors, Nir Hacohen.
Science, 2017 Apr 22; 356(6335). PMID: 28428369    Free PMC article.
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Control of adaptive immunity by the innate immune system.
Akiko Iwasaki, Ruslan Medzhitov.
Nat Immunol, 2015 Mar 20; 16(4). PMID: 25789684    Free PMC article.
Highly Cited. Review.
The Toll-like receptor 1/2 agonists Pam(3) CSK(4) and human β-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes.
Nicholas T Funderburg, Julie K Jadlowsky, +3 authors, Scott F Sieg.
Immunology, 2011 Sep 08; 134(2). PMID: 21896010    Free PMC article.
Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4.
S T Smiley, J A King, W W Hancock.
J Immunol, 2001 Aug 18; 167(5). PMID: 11509636
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The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.
Elie J Diner, Dara L Burdette, +6 authors, Russell E Vance.
Cell Rep, 2013 May 28; 3(5). PMID: 23707065    Free PMC article.
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Phase I clinical trial of a novel autologous modified-DC vaccine in patients with resected NSCLC.
Chunlei Ge, Ruilei Li, +14 authors, Xin Song.
BMC Cancer, 2017 Dec 23; 17(1). PMID: 29268708    Free PMC article.
Targeting nanoparticles to CD40, DEC-205 or CD11c molecules on dendritic cells for efficient CD8(+) T cell response: a comparative study.
Luis J Cruz, Rodney A Rosalia, +3 authors, Ferry Ossendorp.
J Control Release, 2014 Jul 30; 192. PMID: 25068703
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
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Nat Med, 2009 Sep 22; 15(10). PMID: 19767732
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Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny.
Martin Guilliams, Florent Ginhoux, +6 authors, Simon Yona.
Nat Rev Immunol, 2014 Jul 19; 14(8). PMID: 25033907    Free PMC article.
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Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.
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Cell, 2014 Dec 20; 159(7). PMID: 25525874    Free PMC article.
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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L Topalian, F Stephen Hodi, +27 authors, Mario Sznol.
N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658127    Free PMC article.
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IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells.
Thomas Korn, Meike Mitsdoerffer, +9 authors, Mohamed Oukka.
Proc Natl Acad Sci U S A, 2008 Nov 19; 105(47). PMID: 19015529    Free PMC article.
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NF-κB activation triggers NK-cell stimulation by monocyte-derived dendritic cells.
Naomi C Bosch, Reinhard E Voll, +5 authors, Jan Dörrie.
Ther Adv Med Oncol, 2019 Dec 20; 11. PMID: 31853267    Free PMC article.
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.
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Nat Immunol, 2007 Jun 22; 8(9). PMID: 17581537
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Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours.
Jinhua Piao, Yosuke Kamimura, +8 authors, Miyuki Azuma.
Immunology, 2009 Jul 17; 127(4). PMID: 19604302    Free PMC article.
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.
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Nature, 1999 Nov 05; 401(6755). PMID: 10548109
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Quiescence of Memory CD8(+) T Cells Is Mediated by Regulatory T Cells through Inhibitory Receptor CTLA-4.
Vandana Kalia, Laura Anne Penny, +2 authors, Surojit Sarkar.
Immunity, 2015 Jun 18; 42(6). PMID: 26084026
Dendritic cells in cancer immunotherapy.
Camille M Le Gall, Jorieke Weiden, Loek J Eggermont, Carl G Figdor.
Nat Mater, 2018 May 26; 17(6). PMID: 29795222
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Daniel J Wikenheiser, Jason S Stumhofer.
Front Immunol, 2016 Aug 26; 7. PMID: 27559335    Free PMC article.
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Maturation of dendritic cells is a prerequisite for inducing immune responses in advanced melanoma patients.
I Jolanda M de Vries, W Joost Lesterhuis, +9 authors, Cornelis J A Punt.
Clin Cancer Res, 2003 Nov 14; 9(14). PMID: 14613986
Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection.
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Cell Host Microbe, 2009 Nov 18; 6(5). PMID: 19917501    Free PMC article.
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STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice.
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Cancer Immunol Immunother, 2015 May 20; 64(8). PMID: 25986168    Free PMC article.
CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.
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Proc Natl Acad Sci U S A, 2012 Dec 26; 110(3). PMID: 23267099    Free PMC article.
CTLA-4 can function as a negative regulator of T cell activation.
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Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells.
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Nat Immunol, 2005 Jul 05; 6(8). PMID: 15995707    Free PMC article.
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Scott Barbuto, Juliana Idoyaga, +4 authors, Tom W Muir.
Nat Chem Biol, 2013 Feb 19; 9(4). PMID: 23416331    Free PMC article.
Autologous Dendritic Cells Pulsed with Allogeneic Tumor Cell Lysate in Mesothelioma: From Mouse to Human.
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Mol Immunol, 2009 Jan 13; 46(6). PMID: 19135256    Free PMC article.
Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells.
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J Clin Invest, 2005 Nov 26; 115(12). PMID: 16308572    Free PMC article.
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Alejandro Clavero-Álvarez, Tomas Di Mambro, +2 authors, Pierpaolo Bruscolini.
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Targeting OX40 and OX40L for the treatment of autoimmunity and cancer.
William L Redmond, Andrew D Weinberg.
Crit Rev Immunol, 2008 Jan 17; 27(5). PMID: 18197805
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Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation.
Luigi Franchi, Tatjana Eigenbrod, Gabriel Núñez.
J Immunol, 2009 Jun 23; 183(2). PMID: 19542372    Free PMC article.
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Toll-like receptor agonists: are they good adjuvants?
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Inflammation-driven carcinogenesis is mediated through STING.
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Nat Commun, 2014 Oct 11; 5. PMID: 25300616    Free PMC article.
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Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.
Cheng-Ming Sun, Jason A Hall, +4 authors, Yasmine Belkaid.
J Exp Med, 2007 Jul 11; 204(8). PMID: 17620362    Free PMC article.
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Na Li, Wenwen Xu, +11 authors, Li Wang.
Sci Rep, 2017 May 05; 7(1). PMID: 28469254    Free PMC article.
Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine.
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TLR10 Senses HIV-1 Proteins and Significantly Enhances HIV-1 Infection.
Bethany M Henrick, Xiao-Dan Yao, +3 authors, Kenneth L Rosenthal.
Front Immunol, 2019 Apr 02; 10. PMID: 30930906    Free PMC article.
Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer.
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Nat Med, 2020 May 27; 26(6). PMID: 32451498
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Ox40 costimulation enhances the development of T cell responses induced by dendritic cells in vivo.
Thibaut De Smedt, Jeffrey Smith, +3 authors, Charles Maliszewski.
J Immunol, 2002 Jan 05; 168(2). PMID: 11777959
Toward targeting inflammasomes: insights into their regulation and activation.
Shelbi Christgen, David E Place, Thirumala-Devi Kanneganti.
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Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy.
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J Exp Med, 2014 Apr 02; 211(4). PMID: 24687957    Free PMC article.
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Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation.
Rachael Kenworthy, Diana Lambert, +7 authors, Hengli Tang.
Nucleic Acids Res, 2009 Sep 05; 37(19). PMID: 19729514    Free PMC article.
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J Exp Med, 2011 Sep 21; 208(10). PMID: 21930765    Free PMC article.
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Ruth R French, Vadim Y Taraban, +6 authors, Martin J Glennie.
Blood, 2007 Feb 22; 109(11). PMID: 17311995
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Immunity, 2013 Jul 31; 39(1). PMID: 23890065
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Precision cancer immunotherapy: optimizing dendritic cell-based strategies to induce tumor antigen-specific T-cell responses against individual patient tumors.
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J Immunother, 2015 Apr 04; 38(4). PMID: 25839441
Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity.
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J Immunol, 2011 Nov 15; 187(12). PMID: 22079988
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
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Cell, 2012 Jul 24; 150(3). PMID: 22819539    Free PMC article.
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Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer.
Ugur Sahin, Evelyna Derhovanessian, +47 authors, Özlem Türeci.
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K Murata, N Ishii, +5 authors, K Sugamura.
J Exp Med, 2000 Jan 19; 191(2). PMID: 10637280    Free PMC article.
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J Exp Med, 2007 Apr 18; 204(5). PMID: 17438065    Free PMC article.
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Protective humoral immunity elicited by a needle-free malaria vaccine comprised of a chimeric Plasmodium falciparum circumsporozoite protein and a Toll-like receptor 5 agonist, flagellin.
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Infect Immun, 2013 Sep 18; 81(12). PMID: 24042110    Free PMC article.
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Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy.
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VISTA is an immune checkpoint molecule for human T cells.
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DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity.
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Immunity, 2015 Feb 19; 42(2). PMID: 25692705
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J Immunol, 2004 Mar 09; 172(6). PMID: 15004159
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Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth.
Sarah Davidson, Mirjana Efremova, +10 authors, Sarah A Teichmann.
Cell Rep, 2020 May 21; 31(7). PMID: 32433953    Free PMC article.
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A Formulated TLR7/8 Agonist is a Flexible, Highly Potent and Effective Adjuvant for Pandemic Influenza Vaccines.
Neal Van Hoeven, Christopher B Fox, +18 authors, Darrick Carter.
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Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans.
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Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines.
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Dendritic Cell Vaccination Enhances Immune Responses and Induces Regression of HER2pos DCIS Independent of Route: Results of Randomized Selection Design Trial.
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A phase I clinical trial of CD1c (BDCA-1)+ dendritic cells pulsed with HLA-A*0201 peptides for immunotherapy of metastatic hormone refractory prostate cancer.
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Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen.
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A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant.
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Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens.
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Eur J Immunol, 2003 Jan 09; 32(12). PMID: 12516551
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Immunity, 2012 Apr 10; 36(4). PMID: 22483800
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J Immunol, 2014 Jun 11; 193(2). PMID: 24913977
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Nat Immunol, 2007 Dec 07; 9(1). PMID: 18059273
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Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles.
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VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer.
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Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A.
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Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs.
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Engineered niches support the development of human dendritic cells in humanized mice.
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Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains.
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Cell Rep, 2016 Sep 15; 16(11). PMID: 27626665    Free PMC article.
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.
Nicholas McGranahan, Andrew J S Furness, +33 authors, Charles Swanton.
Science, 2016 Mar 05; 351(6280). PMID: 26940869    Free PMC article.
Highly Cited.
Cross-presentation of viral antigens in dribbles leads to efficient activation of virus-specific human memory T cells.
Wei Ye, Yun Xing, +7 authors, Hong-Ming Hu.
J Transl Med, 2014 Apr 17; 12. PMID: 24735498    Free PMC article.
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Seng-Ryong Woo, Mercedes B Fuertes, +9 authors, Thomas F Gajewski.
Immunity, 2014 Dec 18; 41(5). PMID: 25517615    Free PMC article.
Highly Cited.
Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells.
Patrick Fernandes Rodrigues, Llucia Alberti-Servera, +3 authors, Roxane Tussiwand.
Nat Immunol, 2018 Jun 22; 19(7). PMID: 29925996
Highly Cited.
DNA sensing by the cGAS-STING pathway in health and disease.
Mona Motwani, Scott Pesiridis, Katherine A Fitzgerald.
Nat Rev Genet, 2019 Jul 31; 20(11). PMID: 31358977
Highly Cited. Review.
DNA-based immunization by in vivo transfection of dendritic cells.
C Condon, S C Watkins, +2 authors, L D Falo.
Nat Med, 1996 Oct 01; 2(10). PMID: 8837611
Highly Cited.
The interaction properties of costimulatory molecules revisited.
Alison V Collins, Douglas W Brodie, +6 authors, Simon J Davis.
Immunity, 2002 Aug 28; 17(2). PMID: 12196291
Highly Cited.
Transcriptional control of dendritic cell development and functions.
Lukas Amon, Christian H K Lehmann, +3 authors, Diana Dudziak.
Int Rev Cell Mol Biol, 2019 Nov 25; 349. PMID: 31759434
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Ansuman T Satpathy, Carlos G Briseño, +20 authors, Kenneth M Murphy.
Nat Immunol, 2013 Aug 06; 14(9). PMID: 23913046    Free PMC article.
Highly Cited.
PD-1+ natural killer cells in human non-small cell lung cancer can be activated by PD-1/PD-L1 blockade.
Marcel P Trefny, Monika Kaiser, +7 authors, Alfred Zippelius.
Cancer Immunol Immunother, 2020 Apr 17; 69(8). PMID: 32296919
CD8 alpha+, but not CD8 alpha-, dendritic cells tolerize Th2 responses via contact-dependent and -independent mechanisms, and reverse airway hyperresponsiveness, Th2, and eosinophil responses in a mouse model of asthma.
John R Gordon, Fang Li, +2 authors, Xiaobei Zhang.
J Immunol, 2005 Jul 22; 175(3). PMID: 16034089
Activation of autoreactive B cells by CpG dsDNA.
Gregory A Viglianti, Christina M Lau, +3 authors, Ann Marshak-Rothstein.
Immunity, 2003 Dec 13; 19(6). PMID: 14670301
Highly Cited.
RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection.
Yang Zhao, Xiang Ye, +2 authors, John Karijolich.
Nat Commun, 2018 Nov 20; 9(1). PMID: 30451863    Free PMC article.
Highly Cited.
Targeting dendritic cells with antigen-containing liposomes: a highly effective procedure for induction of antitumor immunity and for tumor immunotherapy.
Christina L van Broekhoven, Christopher R Parish, +2 authors, Joseph G Altin.
Cancer Res, 2004 Jun 19; 64(12). PMID: 15205352
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.
M Cella, D Scheidegger, +3 authors, G Alber.
J Exp Med, 1996 Aug 01; 184(2). PMID: 8760829    Free PMC article.
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CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function.
Arata Takeuchi, Takashi Saito.
Front Immunol, 2017 Mar 11; 8. PMID: 28280496    Free PMC article.
Highly Cited. Review.
Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity.
Mikhail Binnewies, Adriana M Mujal, +15 authors, Matthew F Krummel.
Cell, 2019 Apr 09; 177(3). PMID: 30955881    Free PMC article.
Highly Cited.
LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways.
Ke Zhao, Juan Du, +8 authors, Xiao-Fang Yu.
J Autoimmun, 2018 Mar 12; 90. PMID: 29525183
Cutting edge: cardiac myosin activates innate immune responses through TLRs.
Ping Zhang, Carol J Cox, Kathy M Alvarez, Madeleine W Cunningham.
J Immunol, 2009 Jun 19; 183(1). PMID: 19535635    Free PMC article.
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.
A Hutloff, A M Dittrich, +4 authors, R A Kroczek.
Nature, 1999 Feb 04; 397(6716). PMID: 9930702
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Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro.
R M Steinman, Z A Cohn.
J Exp Med, 1974 Feb 01; 139(2). PMID: 4589990    Free PMC article.
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Agonistic CD40 antibodies and cancer therapy.
Robert H Vonderheide, Martin J Glennie.
Clin Cancer Res, 2013 Mar 06; 19(5). PMID: 23460534    Free PMC article.
Highly Cited.
Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells.
Martin Guilliams, Karine Crozat, +7 authors, Bernard Malissen.
Blood, 2010 Jan 14; 115(10). PMID: 20068222
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Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo.
Stephen J Jenkins, Georgia Perona-Wright, +2 authors, Andrew S MacDonald.
J Immunol, 2007 Sep 06; 179(6). PMID: 17785785
A dual role for receptor-interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy.
Craig R Homer, Amrita Kabi, +6 authors, Christine McDonald.
J Biol Chem, 2012 Jun 06; 287(30). PMID: 22665475    Free PMC article.
Dendritic Cell Targeting Using a DNA Vaccine Induces Specific Antibodies and CD4+ T Cells to the Dengue Virus Envelope Protein Domain III.
Arthur Baruel Zaneti, Marcio Massao Yamamoto, +8 authors, Silvia Beatriz Boscardin.
Front Immunol, 2019 Feb 15; 10. PMID: 30761131    Free PMC article.
Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics.
Florian Adanitsch, Jianjin Shi, +3 authors, Alla Zamyatina.
Chem Sci, 2018 May 22; 9(16). PMID: 29780528    Free PMC article.
The multifaceted role of CD4(+) T cells in CD8(+) T cell memory.
Brian J Laidlaw, Joseph E Craft, Susan M Kaech.
Nat Rev Immunol, 2016 Jan 20; 16(2). PMID: 26781939    Free PMC article.
Highly Cited. Review.
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.
R Manetti, P Parronchi, +4 authors, S Romagnani.
J Exp Med, 1993 Apr 01; 177(4). PMID: 8096238    Free PMC article.
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Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.
Lionel Apetoh, François Ghiringhelli, +25 authors, Laurence Zitvogel.
Nat Med, 2007 Aug 21; 13(9). PMID: 17704786
Highly Cited.
Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex.
K Ohashi, V Burkart, S Flohé, H Kolb.
J Immunol, 2000 Jan 07; 164(2). PMID: 10623794
Highly Cited.
Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions.
Sarah Eickhoff, Anna Brewitz, +7 authors, Wolfgang Kastenmüller.
Cell, 2015 Aug 25; 162(6). PMID: 26296422    Free PMC article.
Highly Cited.
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis.
Jeremy B Swann, Matthew D Vesely, +4 authors, Mark J Smyth.
Proc Natl Acad Sci U S A, 2008 Jan 08; 105(2). PMID: 18178624    Free PMC article.
Highly Cited.
Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice.
María Martínez-López, Salvador Iborra, Ruth Conde-Garrosa, David Sancho.
Eur J Immunol, 2014 Oct 15; 45(1). PMID: 25312824    Free PMC article.
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.
Wan-ting He, Haoqiang Wan, +6 authors, Jiahuai Han.
Cell Res, 2015 Nov 28; 25(12). PMID: 26611636    Free PMC article.
Highly Cited.
Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage.
Regine J Dress, Charles-Antoine Dutertre, +15 authors, Florent Ginhoux.
Nat Immunol, 2019 Jun 20; 20(7). PMID: 31213723
Highly Cited.
Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma.
Fujimasa Tada, Masanori Abe, +8 authors, Morikazu Onji.
Int J Oncol, 2012 Sep 14; 41(5). PMID: 22971679    Free PMC article.
MDA5 and LGP2: accomplices and antagonists of antiviral signal transduction.
Kenny R Rodriguez, Annie M Bruns, Curt M Horvath.
J Virol, 2014 May 23; 88(15). PMID: 24850739    Free PMC article.
Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis.
Giovanna Schiavoni, Antonella Sistigu, +10 authors, Laura Bracci.
Cancer Res, 2010 Dec 16; 71(3). PMID: 21156650
Highly Cited.
Mincle is an ITAM-coupled activating receptor that senses damaged cells.
Sho Yamasaki, Eri Ishikawa, +3 authors, Takashi Saito.
Nat Immunol, 2008 Sep 09; 9(10). PMID: 18776906
Highly Cited.
Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity.
Adam D Cohen, Adi Diab, +9 authors, Alan N Houghton.
Cancer Res, 2006 May 03; 66(9). PMID: 16651447    Free PMC article.
Distinct dendritic cell subsets differentially regulate the class of immune response in vivo.
B Pulendran, J L Smith, +4 authors, C R Maliszewski.
Proc Natl Acad Sci U S A, 1999 Feb 03; 96(3). PMID: 9927689    Free PMC article.
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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity.
Hiroki Ishikawa, Zhe Ma, Glen N Barber.
Nature, 2009 Sep 25; 461(7265). PMID: 19776740    Free PMC article.
Highly Cited.
TLR8: the forgotten relative revindicated.
Jorge L Cervantes, Bennett Weinerman, Chaitali Basole, Juan C Salazar.
Cell Mol Immunol, 2012 Oct 23; 9(6). PMID: 23085951    Free PMC article.
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates.
Andreas Pichlmair, Oliver Schulz, +4 authors, Caetano Reis e Sousa.
Science, 2006 Oct 14; 314(5801). PMID: 17038589
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Engagement of the OX-40 receptor in vivo enhances antitumor immunity.
A D Weinberg, M M Rivera, +7 authors, J Shields.
J Immunol, 2000 Feb 05; 164(4). PMID: 10657670
Highly Cited.
CpG-oligodeoxynucleotides developed for grouper toll-like receptor (TLR) 21s effectively activate mouse and human TLR9s mediated immune responses.
Da-Wei Yeh, Chao-Yang Lai, +7 authors, Tsung-Hsien Chuang.
Sci Rep, 2017 Dec 13; 7(1). PMID: 29229937    Free PMC article.
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Lijun Sun, Jiaxi Wu, +2 authors, Zhijian J Chen.
Science, 2012 Dec 22; 339(6121). PMID: 23258413    Free PMC article.
Highly Cited.
Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
Yan Gao, Simone A Nish, +5 authors, Ruslan Medzhitov.
Immunity, 2013 Oct 01; 39(4). PMID: 24076050    Free PMC article.
Highly Cited.
Current State of Dendritic Cell-Based Immunotherapy: Opportunities for in vitro Antigen Loading of Different DC Subsets?
Anne Huber, Floris Dammeijer, Joachim G J V Aerts, Heleen Vroman.
Front Immunol, 2018 Dec 19; 9. PMID: 30559743    Free PMC article.
OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity.
Pejman Soroosh, Shouji Ine, Kazuo Sugamura, Naoto Ishii.
J Immunol, 2006 May 04; 176(10). PMID: 16670306
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity.
David Sancho, Olivier P Joffre, +5 authors, Caetano Reis e Sousa.
Nature, 2009 Feb 17; 458(7240). PMID: 19219027    Free PMC article.
Highly Cited.
Localized expression of GITR-L in the tumor microenvironment promotes CD8+ T cell dependent anti-tumor immunity.
John S Cho, Jeffrey V Hsu, Sherie L Morrison.
Cancer Immunol Immunother, 2008 Nov 20; 58(7). PMID: 19018533    Free PMC article.
Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade.
Nicolas Jacquelot, Takahiro Yamazaki, +30 authors, Laurence Zitvogel.
Cell Res, 2019 Sep 05; 29(10). PMID: 31481761    Free PMC article.
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Jane Tian, Ana Maria Avalos, +19 authors, Anthony J Coyle.
Nat Immunol, 2007 Apr 10; 8(5). PMID: 17417641
Highly Cited.
Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.
H Tahara, L Zitvogel, +6 authors, M T Lotze.
J Immunol, 1995 Jun 15; 154(12). PMID: 7759882
PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity.
Sarah L Buchan, Mohannad Fallatah, +8 authors, Aymen Al-Shamkhani.
Clin Cancer Res, 2018 Mar 09; 24(10). PMID: 29514845    Free PMC article.
Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment.
Gordon F Heidkamp, Jil Sander, +28 authors, Diana Dudziak.
Sci Immunol, 2017 Aug 08; 1(6). PMID: 28783692
Highly Cited.
Ontogenic, Phenotypic, and Functional Characterization of XCR1(+) Dendritic Cells Leads to a Consistent Classification of Intestinal Dendritic Cells Based on the Expression of XCR1 and SIRPα.
Martina Becker, Steffen Güttler, +8 authors, Richard A Kroczek.
Front Immunol, 2014 Aug 15; 5. PMID: 25120540    Free PMC article.
FcgammaRIV: a novel FcR with distinct IgG subclass specificity.
Falk Nimmerjahn, Pierre Bruhns, Ken Horiuchi, Jeffrey V Ravetch.
Immunity, 2005 Jul 26; 23(1). PMID: 16039578
Highly Cited.
The NLRP3 inflammasome: molecular activation and regulation to therapeutics.
Karen V Swanson, Meng Deng, Jenny P-Y Ting.
Nat Rev Immunol, 2019 May 01; 19(8). PMID: 31036962    Free PMC article.
Highly Cited. Review.
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies.
Jérôme Galon, Daniela Bruni.
Nat Rev Drug Discov, 2019 Jan 06; 18(3). PMID: 30610226
Highly Cited. Review.
Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.
Udupi A Ramagopal, Weifeng Liu, +10 authors, Steven C Almo.
Proc Natl Acad Sci U S A, 2017 May 10; 114(21). PMID: 28484017    Free PMC article.
Deciphering the transcriptional network of the dendritic cell lineage.
Jennifer C Miller, Brian D Brown, +18 authors, Immunological Genome Consortium.
Nat Immunol, 2012 Jul 17; 13(9). PMID: 22797772    Free PMC article.
Highly Cited.
Defective CD8 T cell memory following acute infection without CD4 T cell help.
Joseph C Sun, Michael J Bevan.
Science, 2003 Apr 12; 300(5617). PMID: 12690202    Free PMC article.
Highly Cited.
The presence of T cell epitopes is important for induction of antibody responses against antigens directed to DEC205+ dendritic cells.
Kelly N S Amorim, Eline V Rampazo, +4 authors, Silvia B Boscardin.
Sci Rep, 2016 Dec 22; 6. PMID: 28000705    Free PMC article.
NOD proteins: regulators of inflammation in health and disease.
Dana J Philpott, Matthew T Sorbara, +2 authors, Stephen E Girardin.
Nat Rev Immunol, 2013 Dec 18; 14(1). PMID: 24336102
Highly Cited. Review.
Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific for Endocytic Receptors as a Promising Strategy for Future Therapies.
Christian H K Lehmann, Lukas Heger, +4 authors, Diana Dudziak.
Vaccines (Basel), 2016 Apr 05; 4(2). PMID: 27043640    Free PMC article.
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms.
Richard V Parry, Jens M Chemnitz, +6 authors, James L Riley.
Mol Cell Biol, 2005 Oct 18; 25(21). PMID: 16227604    Free PMC article.
Highly Cited.
Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens.
Kathryn J Farrand, Nina Dickgreber, +3 authors, Ian F Hermans.
J Immunol, 2009 Nov 20; 183(12). PMID: 19923446
Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells.
F Takeshita, C A Leifer, +4 authors, D M Klinman.
J Immunol, 2001 Sep 21; 167(7). PMID: 11564765
Highly Cited.
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.
Sarah M McWhirter, Roman Barbalat, +10 authors, Russell E Vance.
J Exp Med, 2009 Aug 05; 206(9). PMID: 19652017    Free PMC article.
Highly Cited.
Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells.
Miriam Merad, Florent Ginhoux, Matthew Collin.
Nat Rev Immunol, 2008 Nov 26; 8(12). PMID: 19029989
Highly Cited. Review.
Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies.
Raanan Berger, Rinat Rotem-Yehudar, +6 authors, Arnon Nagler.
Clin Cancer Res, 2008 May 17; 14(10). PMID: 18483370
Highly Cited.
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.
Haidong Dong, Scott E Strome, +10 authors, Lieping Chen.
Nat Med, 2002 Jul 02; 8(8). PMID: 12091876
Highly Cited.
Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population.
Rebecca Leylek, Marcela Alcántara-Hernández, +4 authors, Juliana Idoyaga.
Cell Rep, 2019 Dec 12; 29(11). PMID: 31825848    Free PMC article.
Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/beta.
Marc Dalod, Tanya Hamilton, +4 authors, Christine A Biron.
J Exp Med, 2003 Apr 19; 197(7). PMID: 12682109    Free PMC article.
Highly Cited.
Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets.
Diego Piccioli, Simona Tavarini, +7 authors, Andreas Wack.
Blood, 2007 Mar 03; 109(12). PMID: 17332250
Adjuvant immunotherapy with autologous dendritic cells for hepatocellular carcinoma, randomized phase II study.
Jeong-Hoon Lee, Won Young Tak, +10 authors, Yoon Jun Kim.
Oncoimmunology, 2017 Aug 16; 6(7). PMID: 28811965    Free PMC article.
Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability.
N Romani, D Reider, +5 authors, G Schuler.
J Immunol Methods, 1996 Sep 27; 196(2). PMID: 8841452
Highly Cited.
Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells.
Sammy Bedoui, Paul G Whitney, +9 authors, William R Heath.
Nat Immunol, 2009 Apr 08; 10(5). PMID: 19349986
Highly Cited.
Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague.
Yoonkyung Do, Hyein Koh, +9 authors, Ralph M Steinman.
Eur J Immunol, 2010 Sep 03; 40(10). PMID: 20812236
Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.
Jörg H Fritz, Lionel Le Bourhis, +8 authors, Dana J Philpott.
Immunity, 2007 Apr 17; 26(4). PMID: 17433730
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
Nobuhiko Kayagaki, Irma B Stowe, +22 authors, Vishva M Dixit.
Nature, 2015 Sep 17; 526(7575). PMID: 26375259
Highly Cited.
Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants.
Thomas W Dubensky, David B Kanne, Meredith L Leong.
Ther Adv Vaccines, 2014 Apr 24; 1(4). PMID: 24757520    Free PMC article.
Toll-like receptor 3 promotes cross-priming to virus-infected cells.
Oliver Schulz, Sandra S Diebold, +7 authors, Caetano Reis e Sousa.
Nature, 2005 Feb 16; 433(7028). PMID: 15711573
Highly Cited.
The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells.
Gerty Schreibelt, Lieke J J Klinkenberg, +7 authors, I Jolanda M de Vries.
Blood, 2012 Jan 12; 119(10). PMID: 22234694
Highly Cited.
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
Andrea Ablasser, Jonathan L Schmid-Burgk, +4 authors, Veit Hornung.
Nature, 2013 Oct 01; 503(7477). PMID: 24077100    Free PMC article.
Highly Cited.
The protective effect of the anti-Toll-like receptor 9 antibody against acute cytokine storm caused by immunostimulatory DNA.
Yusuke Murakami, Ryutaro Fukui, +4 authors, Kensuke Miyake.
Sci Rep, 2017 Mar 08; 7. PMID: 28266597    Free PMC article.
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance.
Jun Shimizu, Sayuri Yamazaki, +2 authors, Shimon Sakaguchi.
Nat Immunol, 2002 Jan 29; 3(2). PMID: 11812990
Highly Cited.
Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.
Osamu Takeuchi, Shintaro Sato, +5 authors, Shizuo Akira.
J Immunol, 2002 Jun 22; 169(1). PMID: 12077222
Highly Cited.
Dendritic cell-based nanovaccines for cancer immunotherapy.
Leonie E Paulis, Subhra Mandal, Martin Kreutz, Carl G Figdor.
Curr Opin Immunol, 2013 Apr 11; 25(3). PMID: 23571027
STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment.
Steven Lohard, Nathalie Bourgeois, +15 authors, Sophie Barillé-Nion.
Nat Commun, 2020 Jan 16; 11(1). PMID: 31937780    Free PMC article.
Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.
Warrison A Andrade, Maria do Carmo Souza, +7 authors, Ricardo T Gazzinelli.
Cell Host Microbe, 2013 Jan 08; 13(1). PMID: 23290966    Free PMC article.
Highly Cited.
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.
F Sallusto, A Lanzavecchia.
J Exp Med, 1994 Apr 01; 179(4). PMID: 8145033    Free PMC article.
Highly Cited.
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors.
Elizabeth A Leadbetter, Ian R Rifkin, +3 authors, Ann Marshak-Rothstein.
Nature, 2002 Apr 12; 416(6881). PMID: 11948342
Highly Cited.
Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.
Alice O Kamphorst, Andreas Wieland, +17 authors, Rafi Ahmed.
Science, 2017 Mar 11; 355(6332). PMID: 28280249    Free PMC article.
Highly Cited.
The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells.
H Kitamura, K Iwakabe, +10 authors, T Nishimura.
J Exp Med, 1999 Apr 06; 189(7). PMID: 10190903    Free PMC article.
Highly Cited.
NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.
Hexin Shi, Ying Wang, +21 authors, Bruce Beutler.
Nat Immunol, 2015 Dec 08; 17(3). PMID: 26642356    Free PMC article.
Highly Cited.
DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.
David Roulois, Helen Loo Yau, +9 authors, Daniel D De Carvalho.
Cell, 2015 Sep 01; 162(5). PMID: 26317465    Free PMC article.
Highly Cited.
Langerhans cells cross-present antigen derived from skin.
Patrizia Stoitzner, Christoph H Tripp, +5 authors, Nikolaus Romani.
Proc Natl Acad Sci U S A, 2006 May 05; 103(20). PMID: 16672373    Free PMC article.
Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34(+) progenitor-derived dendritic cells.
Joseph W Fay, A Karolina Palucka, +5 authors, Jacques Banchereau.
Cancer Immunol Immunother, 2005 Dec 07; 55(10). PMID: 16331519
The origins and functions of dendritic cells and macrophages in the skin.
Bernard Malissen, Samira Tamoutounour, Sandrine Henri.
Nat Rev Immunol, 2014 May 24; 14(6). PMID: 24854591
Highly Cited. Review.
Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer.
Clemence Granier, Eleonore De Guillebon, +7 authors, Eric Tartour.
ESMO Open, 2017 Aug 02; 2(2). PMID: 28761757    Free PMC article.
Highly Cited. Review.
T cell exclusion, immune privilege, and the tumor microenvironment.
Johanna A Joyce, Douglas T Fearon.
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Highly Cited. Review.
Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer.
Leticia Corrales, Thomas F Gajewski.
Clin Cancer Res, 2015 Sep 17; 21(21). PMID: 26373573    Free PMC article.
T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.
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Proc Natl Acad Sci U S A, 2011 May 18; 108(22). PMID: 21576490    Free PMC article.
Highly Cited.
Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling-Induced Nontranscriptional Priming of the NLRP3 Inflammasome.
Yue Xing, Xiaomin Yao, +6 authors, Guangxun Meng.
J Immunol, 2017 Jul 26; 199(5). PMID: 28739881
The lineage decisions of helper T cells.
Kenneth M Murphy, Steven L Reiner.
Nat Rev Immunol, 2002 Dec 04; 2(12). PMID: 12461566
Highly Cited. Review.
Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors.
Baidong Hou, Alicia Benson, +2 authors, Felix Yarovinsky.
Proc Natl Acad Sci U S A, 2010 Dec 22; 108(1). PMID: 21173242    Free PMC article.
Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts.
Sergio A Quezada, Tyler R Simpson, +9 authors, James P Allison.
J Exp Med, 2010 Feb 17; 207(3). PMID: 20156971    Free PMC article.
Highly Cited.
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.
Melissa A Kinnebrew, Charlie G Buffie, +6 authors, Eric G Pamer.
Immunity, 2012 Feb 07; 36(2). PMID: 22306017    Free PMC article.
Highly Cited.
In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology.
Susmit Suvas, Bumseok Kim, +3 authors, Barry T Rouse.
J Virol, 2005 Sep 06; 79(18). PMID: 16140769    Free PMC article.
Neoantigens in cancer immunotherapy.
Ton N Schumacher, Robert D Schreiber.
Science, 2015 Apr 04; 348(6230). PMID: 25838375
Highly Cited. Review.
Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.
M A Campos, I C Almeida, +7 authors, R T Gazzinelli.
J Immunol, 2001 Jun 22; 167(1). PMID: 11418678
Highly Cited.
Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function.
Julie M Curtsinger, Debra C Lins, Matthew F Mescher.
J Exp Med, 2003 May 07; 197(9). PMID: 12732656    Free PMC article.
Highly Cited.
Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells.
Anita Sapoznikov, Jens A A Fischer, +3 authors, Steffen Jung.
J Exp Med, 2007 Jul 25; 204(8). PMID: 17646404    Free PMC article.
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.
Sandra S Diebold, Tsuneyasu Kaisho, +2 authors, Caetano Reis e Sousa.
Science, 2004 Feb 21; 303(5663). PMID: 14976261
Highly Cited.
Diversification of human plasmacytoid predendritic cells in response to a single stimulus.
Solana G Alculumbre, Violaine Saint-André, +15 authors, Vassili Soumelis.
Nat Immunol, 2017 Dec 06; 19(1). PMID: 29203862
CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells.
Simona Sivori, Michela Falco, +4 authors, Alessandro Moretta.
Proc Natl Acad Sci U S A, 2004 Jun 26; 101(27). PMID: 15218108    Free PMC article.
Highly Cited.
Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells.
Muzlifah Haniffa, Amanda Shin, +25 authors, Florent Ginhoux.
Immunity, 2012 Jul 17; 37(1). PMID: 22795876    Free PMC article.
Highly Cited.
Prospects for CD40-directed experimental therapy of human cancer.
Alex W Tong, Marvin J Stone.
Cancer Gene Ther, 2002 Dec 19; 10(1). PMID: 12489023
Immune modules shared by innate lymphoid cells and T cells.
Michelle L Robinette, Marco Colonna.
J Allergy Clin Immunol, 2016 Nov 08; 138(5). PMID: 27817796    Free PMC article.
GITR ligand fusion protein agonist enhances the tumor antigen-specific CD8 T-cell response and leads to long-lasting memory.
Nick M Durham, Nick Holoweckyj, +3 authors, Scott H Robbins.
J Immunother Cancer, 2017 Jun 27; 5. PMID: 28649380    Free PMC article.
Nivolumab plus ipilimumab in advanced melanoma.
Jedd D Wolchok, Harriet Kluger, +21 authors, Mario Sznol.
N Engl J Med, 2013 Jun 04; 369(2). PMID: 23724867    Free PMC article.
Highly Cited.
Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.
Henning Lauterbach, Barbara Bathke, +13 authors, Hubertus Hochrein.
J Exp Med, 2010 Oct 27; 207(12). PMID: 20975040    Free PMC article.
Highly Cited.
Different cross-presentation pathways in steady-state and inflammatory dendritic cells.
Elodie Segura, Anthony L Albiston, +2 authors, José A Villadangos.
Proc Natl Acad Sci U S A, 2009 Nov 18; 106(48). PMID: 19918052    Free PMC article.
SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis.
Ciriana Orabona, Maria T Pallotta, +7 authors, Paolo Puccetti.
Proc Natl Acad Sci U S A, 2008 Dec 18; 105(52). PMID: 19088199    Free PMC article.
Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.
B Kwon, K Y Yu, +7 authors, B S Kwon.
J Biol Chem, 1999 Feb 26; 274(10). PMID: 10037686
The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions.
Sonia Feau, Zacarias Garcia, +3 authors, Stephen P Schoenberger.
Nat Commun, 2012 Jul 12; 3. PMID: 22781761    Free PMC article.
FOXD3 Regulates VISTA Expression in Melanoma.
Sheera R Rosenbaum, Meghan Knecht, +11 authors, Andrew E Aplin.
Cell Rep, 2020 Jan 16; 30(2). PMID: 31940493    Free PMC article.
Toll-like receptor signalling.
Shizuo Akira, Kiyoshi Takeda.
Nat Rev Immunol, 2004 Jul 02; 4(7). PMID: 15229469
Highly Cited. Review.
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.
Alvin Lu, Venkat Giri Magupalli, +7 authors, Edward H Egelman.
Cell, 2014 Mar 19; 156(6). PMID: 24630722    Free PMC article.
Highly Cited.
BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction.
A Dzionek, Y Sohma, +14 authors, J Schmitz.
J Exp Med, 2001 Dec 19; 194(12). PMID: 11748283    Free PMC article.
Highly Cited.
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
Tadashi Yokosuka, Masako Takamatsu, +3 authors, Takashi Saito.
J Exp Med, 2012 May 30; 209(6). PMID: 22641383    Free PMC article.
Highly Cited.
Coinhibitory receptor PD-1H preferentially suppresses CD4⁺ T cell-mediated immunity.
Dallas B Flies, Xue Han, +4 authors, Lieping Chen.
J Clin Invest, 2014 Apr 20; 124(5). PMID: 24743150    Free PMC article.
Highly Cited.
PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer.
Brian Diskin, Salma Adam, +32 authors, George Miller.
Nat Immunol, 2020 Mar 11; 21(4). PMID: 32152508
CD8(+) T-cell priming and boosting: more antigen-presenting DC, or more antigen per DC?
Niels Schaft, Verena Wellner, +2 authors, Jan Dörrie.
Cancer Immunol Immunother, 2013 Oct 12; 62(12). PMID: 24114143
CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression.
L J Appleman, A Berezovskaya, I Grass, V A Boussiotis.
J Immunol, 1999 Dec 22; 164(1). PMID: 10605005
Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells.
R M Vabulas, P Ahmad-Nejad, +4 authors, H Wagner.
J Biol Chem, 2001 Jun 13; 276(33). PMID: 11402040
Highly Cited.
A monoclonal antibody specific for mouse dendritic cells.
M C Nussenzweig, R M Steinman, M D Witmer, B Gutchinov.
Proc Natl Acad Sci U S A, 1982 Jan 01; 79(1). PMID: 6948298    Free PMC article.
Highly Cited.
Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination.
Kristen A Batich, Elizabeth A Reap, +14 authors, John H Sampson.
Clin Cancer Res, 2017 Apr 16; 23(8). PMID: 28411277    Free PMC article.
Highly Cited.
Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses.
Eduardo J Villablanca, Laura Raccosta, +15 authors, Vincenzo Russo.
Nat Med, 2009 Dec 29; 16(1). PMID: 20037595
Structural basis of toll-like receptor 3 signaling with double-stranded RNA.
Lin Liu, Istvan Botos, +4 authors, David R Davies.
Science, 2008 Apr 19; 320(5874). PMID: 18420935    Free PMC article.
Highly Cited.
Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice.
Cheng-Hu Liu, Yu-ting Fan, +5 authors, Julio Aliberti.
J Immunol, 2006 Jun 21; 177(1). PMID: 16785494
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota.
Marie Vétizou, Jonathan M Pitt, +35 authors, Laurence Zitvogel.
Science, 2015 Nov 07; 350(6264). PMID: 26541610    Free PMC article.
Highly Cited.
Profiling MHC II immunopeptidome of blood-stage malaria reveals that cDC1 control the functionality of parasite-specific CD4 T cells.
Marion Draheim, Myriam F Wlodarczyk, +12 authors, Nicolas Blanchard.
EMBO Mol Med, 2017 Sep 25; 9(11). PMID: 28935714    Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection.
Cedric Bosteels, Katrijn Neyt, +18 authors, Bart N Lambrecht.
Immunity, 2020 May 12; 52(6). PMID: 32392463    Free PMC article.
Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4+ and CD8+ T Cell Activation to Localized Viral Infection.
Jyh Liang Hor, Paul G Whitney, +3 authors, Scott N Mueller.
Immunity, 2015 Aug 25; 43(3). PMID: 26297566
Highly Cited.
Antibody humanization methods - a review and update.
Yaghoub Safdari, Safar Farajnia, Mohammad Asgharzadeh, Masoumeh Khalili.
Biotechnol Genet Eng Rev, 2014 Feb 27; 29. PMID: 24568279
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Franz G Bauernfeind, Gabor Horvath, +9 authors, Eicke Latz.
J Immunol, 2009 Jul 03; 183(2). PMID: 19570822    Free PMC article.
Highly Cited.
Impact of oncogenic pathways on evasion of antitumour immune responses.
Stefani Spranger, Thomas F Gajewski.
Nat Rev Cancer, 2018 Jan 13; 18(3). PMID: 29326431    Free PMC article.
Highly Cited. Review.
IDO expression by dendritic cells: tolerance and tryptophan catabolism.
Andrew L Mellor, David H Munn.
Nat Rev Immunol, 2004 Oct 02; 4(10). PMID: 15459668
Highly Cited. Review.
Fcgamma receptors: old friends and new family members.
Falk Nimmerjahn, Jeffrey V Ravetch.
Immunity, 2006 Jan 18; 24(1). PMID: 16413920
Highly Cited. Review.
In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles.
Young Jik Kwon, Edward James, Nilabh Shastri, Jean M J Fréchet.
Proc Natl Acad Sci U S A, 2005 Dec 14; 102(51). PMID: 16344458    Free PMC article.
Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation.
Austin Pantel, Angela Teixeira, +3 authors, M Paula Longhi.
PLoS Biol, 2014 Jan 11; 12(1). PMID: 24409099    Free PMC article.
Highly Cited.
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.
Thomas Korn, Estelle Bettelli, +5 authors, Vijay K Kuchroo.
Nature, 2007 Jun 22; 448(7152). PMID: 17581588    Free PMC article.
Highly Cited.
Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti-CTLA-4 therapy.
Derek Ng Tang, Yu Shen, +5 authors, Padmanee Sharma.
Cancer Immunol Res, 2014 Apr 30; 1(4). PMID: 24777852    Free PMC article.
Highly Cited.
A conserved dendritic-cell regulatory program limits antitumour immunity.
Barbara Maier, Andrew M Leader, +20 authors, Miriam Merad.
Nature, 2020 Apr 10; 580(7802). PMID: 32269339    Free PMC article.
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.
H Dong, G Zhu, K Tamada, L Chen.
Nat Med, 1999 Dec 02; 5(12). PMID: 10581077
Highly Cited.
IRF family proteins and type I interferon induction in dendritic cells.
Prafullakumar Tailor, Tomohiko Tamura, Keiko Ozato.
Cell Res, 2006 Feb 14; 16(2). PMID: 16474425
Glycan-Based Cell Targeting To Modulate Immune Responses.
Timo Johannssen, Bernd Lepenies.
Trends Biotechnol, 2017 Mar 10; 35(4). PMID: 28277249
Mitochondrial double-stranded RNA triggers antiviral signalling in humans.
Ashish Dhir, Somdutta Dhir, +15 authors, Nicholas J Proudfoot.
Nature, 2018 Jul 27; 560(7717). PMID: 30046113    Free PMC article.
Highly Cited.
Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs.
Tiffany F Chen, Stephen L Sazinsky, +8 authors, K Dane Wittrup.
J Mol Biol, 2017 Jul 12; 429(16). PMID: 28694069    Free PMC article.
Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions.
A I Chen, A J McAdam, +8 authors, A H Sharpe.
Immunity, 2000 Jan 08; 11(6). PMID: 10626891
OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors.
Y Ohshima, L P Yang, +5 authors, G Delespesse.
Blood, 1998 Oct 27; 92(9). PMID: 9787171
CD70 is downregulated by interaction with CD27.
Mirela Kuka, Ivana Munitic, Maria Letizia Giardino Torchia, Jonathan D Ashwell.
J Immunol, 2013 Aug 06; 191(5). PMID: 23913967    Free PMC article.
Elements of cancer immunity and the cancer-immune set point.
Daniel S Chen, Ira Mellman.
Nature, 2017 Jan 20; 541(7637). PMID: 28102259
Highly Cited. Review.
Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation.
Sadeem Ahmad, Xin Mu, +5 authors, Sun Hur.
Cell, 2018 Feb 06; 172(4). PMID: 29395326    Free PMC article.
Highly Cited.
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Jianjin Shi, Yue Zhao, +7 authors, Feng Shao.
Nature, 2015 Sep 17; 526(7575). PMID: 26375003
Highly Cited.
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis.
Yan Zheng, Dimitry M Danilenko, +4 authors, Wenjun Ouyang.
Nature, 2006 Dec 26; 445(7128). PMID: 17187052
Highly Cited.
C-type lectin receptors on dendritic cells and Langerhans cells.
Carl G Figdor, Yvette van Kooyk, Gosse J Adema.
Nat Rev Immunol, 2002 Mar 26; 2(2). PMID: 11910898
Highly Cited. Review.
Dendritic cell migration in health and disease.
Tim Worbs, Swantje I Hammerschmidt, Reinhold Förster.
Nat Rev Immunol, 2016 Nov 29; 17(1). PMID: 27890914
Highly Cited. Review.
CLEC12A-Mediated Antigen Uptake and Cross-Presentation by Human Dendritic Cell Subsets Efficiently Boost Tumor-Reactive T Cell Responses.
Tim J A Hutten, Soley Thordardottir, +13 authors, Willemijn Hobo.
J Immunol, 2016 Aug 28; 197(7). PMID: 27566820
Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues.
Hong Chen, Chrysoula I Liakou, +8 authors, Padmanee Sharma.
Proc Natl Acad Sci U S A, 2009 Feb 10; 106(8). PMID: 19202079    Free PMC article.
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2.
T Shiratori, S Miyatake, +4 authors, T Saito.
Immunity, 1997 May 01; 6(5). PMID: 9175836
Ontogeny and function of murine epidermal Langerhans cells.
Daniel H Kaplan.
Nat Immunol, 2017 Sep 20; 18(10). PMID: 28926543    Free PMC article.
Preclinical evaluation of NF-κB-triggered dendritic cells expressing the viral oncogenic driver of Merkel cell carcinoma for therapeutic vaccination.
Kerstin F Gerer, Michael Erdmann, +8 authors, Jan Dörrie.
Ther Adv Med Oncol, 2017 Jul 19; 9(7). PMID: 28717398    Free PMC article.
VISTA Regulates the Development of Protective Antitumor Immunity.
Isabelle Le Mercier, Wenna Chen, +5 authors, Li Wang.
Cancer Res, 2014 Apr 03; 74(7). PMID: 24691994    Free PMC article.
Highly Cited.
Rapid induction of tumor-specific type 1 T helper cells in metastatic melanoma patients by vaccination with mature, cryopreserved, peptide-loaded monocyte-derived dendritic cells.
Beatrice Schuler-Thurner, Erwin S Schultz, +8 authors, Gerold Schuler.
J Exp Med, 2002 May 22; 195(10). PMID: 12021308    Free PMC article.
Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice.
Gabrielle T Belz, Dominik Wodarz, +2 authors, Peter C Doherty.
J Virol, 2002 Nov 05; 76(23). PMID: 12414983    Free PMC article.
Highly Cited.
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes.
Edith M Janssen, Edward E Lemmens, +3 authors, Stephen P Schoenberger.
Nature, 2003 Feb 21; 421(6925). PMID: 12594515
Highly Cited.
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.
A O Aliprantis, R B Yang, +6 authors, A Zychlinsky.
Science, 1999 Jul 31; 285(5428). PMID: 10426996
Highly Cited.
Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells.
Brian Ruffell, Debbie Chang-Strachan, +7 authors, Lisa M Coussens.
Cancer Cell, 2014 Dec 03; 26(5). PMID: 25446896    Free PMC article.
Highly Cited.
Pore-forming activity and structural autoinhibition of the gasdermin family.
Jingjin Ding, Kun Wang, +6 authors, Feng Shao.
Nature, 2016 Jun 10; 535(7610). PMID: 27281216
Highly Cited.
Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon.
Agnes Le Bon, Nathalie Etchart, +5 authors, David F Tough.
Nat Immunol, 2003 Sep 23; 4(10). PMID: 14502286
Highly Cited.
Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice.
M J Mendez, L L Green, +20 authors, A Jakobovits.
Nat Genet, 1997 Feb 01; 15(2). PMID: 9020839
STING manifests self DNA-dependent inflammatory disease.
Jeonghyun Ahn, Delia Gutman, Shinobu Saijo, Glen N Barber.
Proc Natl Acad Sci U S A, 2012 Nov 08; 109(47). PMID: 23132945    Free PMC article.
Highly Cited.
A liposome-based antigen delivery system using pH-sensitive fusogenic polymers for cancer immunotherapy.
Eiji Yuba, Atsushi Harada, +2 authors, Kenji Kono.
Biomaterials, 2013 Feb 05; 34(12). PMID: 23374704
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
O Takeuchi, K Hoshino, +5 authors, S Akira.
Immunity, 1999 Nov 05; 11(4). PMID: 10549626
Highly Cited.
TLR-dependent T cell activation in autoimmunity.
Kingston H G Mills.
Nat Rev Immunol, 2011 Nov 19; 11(12). PMID: 22094985
Highly Cited. Review.
Immunogenicity to Biotherapeutics - The Role of Anti-drug Immune Complexes.
Murli Krishna, Steven G Nadler.
Front Immunol, 2016 Feb 13; 7. PMID: 26870037    Free PMC article.
Highly Cited. Review.
CD180 Ligation Inhibits TLR7- and TLR9-Mediated Activation of Macrophages and Dendritic Cells Through the Lyn-SHP-1/2 Axis in Murine Lupus.
Yonghong Yang, Cuiling Wang, +7 authors, Huabao Xiong.
Front Immunol, 2018 Dec 01; 9. PMID: 30498494    Free PMC article.
Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma.
Einar Osland Vik-Mo, Marta Nyakas, +13 authors, Iver A Langmoen.
Cancer Immunol Immunother, 2013 Jul 03; 62(9). PMID: 23817721    Free PMC article.
Highly Cited.
The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells.
Yan Wang, Jernej Godec, +7 authors, Vanja Lazarevic.
Immunity, 2014 Feb 18; 40(3). PMID: 24530058    Free PMC article.
Highly Cited.
Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life.
Tomer Granot, Takashi Senda, +12 authors, Donna L Farber.
Immunity, 2017 Mar 23; 46(3). PMID: 28329707    Free PMC article.
Highly Cited.
Efficient immune responses against Intimin and EspB of enterohaemorragic Escherichia coli after intranasal vaccination using the TLR2/6 agonist MALP-2 as adjuvant.
Angel Cataldi, Tetyana Yevsa, +6 authors, Carlos A Guzmán.
Vaccine, 2008 Aug 05; 26(44). PMID: 18675866
The GITRL-GITR system alters TLR-4 expression on DC during fungal infection.
Anna Vecchiarelli, Eva Pericolini, +5 authors, Carlo Riccardi.
Cell Immunol, 2009 Mar 11; 257(1-2). PMID: 19272591
Non-apoptotic role of BID in inflammation and innate immunity.
Garabet Yeretssian, Ricardo G Correa, +5 authors, Maya Saleh.
Nature, 2011 May 10; 474(7349). PMID: 21552281
Critical Role for Skin-Derived Migratory DCs and Langerhans Cells in TFH and GC Responses after Intradermal Immunization.
Clément Levin, Olivia Bonduelle, +4 authors, Béhazine Combadière.
J Invest Dermatol, 2017 May 02; 137(9). PMID: 28457909
Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responses.
Elizabeth B Wilson, Alexandra M Livingstone.
J Immunol, 2008 Nov 20; 181(11). PMID: 19017930
Fcγ receptor antigen targeting potentiates cross-presentation by human blood and lymphoid tissue BDCA-3+ dendritic cells.
Thijs W H Flinsenberg, Ewoud B Compeer, +5 authors, Marianne Boes.
Blood, 2012 Oct 25; 120(26). PMID: 23093620
Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood.
A Bender, M Sapp, +2 authors, N Bhardwaj.
J Immunol Methods, 1996 Sep 27; 196(2). PMID: 8841451
Highly Cited.
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species.
Martin Guilliams, Charles-Antoine Dutertre, +29 authors, Florent Ginhoux.
Immunity, 2016 Sep 18; 45(3). PMID: 27637149    Free PMC article.
Highly Cited.
Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection.
Manfred Brigl, Raju V V Tatituri, +7 authors, Michael B Brenner.
J Exp Med, 2011 May 11; 208(6). PMID: 21555485    Free PMC article.
Highly Cited.
Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition.
Hélène Salmon, Juliana Idoyaga, +19 authors, Miriam Merad.
Immunity, 2016 Apr 21; 44(4). PMID: 27096321    Free PMC article.
Highly Cited.
The clinical application of cancer immunotherapy based on naturally circulating dendritic cells.
Kalijn F Bol, Gerty Schreibelt, +11 authors, I Jolanda M de Vries.
J Immunother Cancer, 2019 Apr 20; 7(1). PMID: 30999964    Free PMC article.
Highly Cited. Review.
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.
Leonardo H Travassos, Leticia A M Carneiro, +13 authors, Dana J Philpott.
Nat Immunol, 2009 Nov 10; 11(1). PMID: 19898471
Highly Cited.
Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells.
Venetia Bigley, Naomi McGovern, +5 authors, Matthew Collin.
J Leukoc Biol, 2014 Dec 18; 97(4). PMID: 25516751    Free PMC article.
Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein.
L M Higgins, S A McDonald, +3 authors, T T MacDonald.
J Immunol, 1999 Jan 14; 162(1). PMID: 9886424
CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses.
Fernanda V V Castro, Alison L Tutt, +4 authors, Martin J Glennie.
Eur J Immunol, 2008 Jul 25; 38(8). PMID: 18651710
Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help.
S R Bennett, F R Carbone, +2 authors, W R Heath.
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Highly Cited.
The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon.
Chen Wang, Taoyong Chen, +4 authors, Xuetao Cao.
Nat Immunol, 2009 Jun 02; 10(7). PMID: 19483718
Highly Cited.
Adaptive immune activation: glycosylation does matter.
Margreet A Wolfert, Geert-Jan Boons.
Nat Chem Biol, 2013 Nov 16; 9(12). PMID: 24231619    Free PMC article.
Highly Cited.
Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation.
Jesse W Williams, Melissa Y Tjota, +9 authors, Anne I Sperling.
Nat Commun, 2013 Dec 21; 4. PMID: 24356538    Free PMC article.
Highly Cited.
Enhanced antitumor immunity by targeting dendritic cells with tumor cell lysate-loaded chitosan nanoparticles vaccine.
Gao-Na Shi, Chuang-Nian Zhang, +8 authors, De-Ling Kong.
Biomaterials, 2016 Nov 07; 113. PMID: 27816821
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Nat Med, 2009 Dec 08; 16(1). PMID: 19966812
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Human TLR10 is an anti-inflammatory pattern-recognition receptor.
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Nat Immunol, 2013 Mar 26; 14(5). PMID: 23525089    Free PMC article.
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J Immunol, 2000 Mar 08; 164(6). PMID: 10706685
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J Immunol, 1999 Sep 22; 163(7). PMID: 10490993
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Hiroki Kato, Osamu Takeuchi, +15 authors, Shizuo Akira.
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Marian L Turner, Frauke M Schnorfeil, Thomas Brocker.
J Immunol, 2011 Oct 05; 187(8). PMID: 21969315
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Nat Immunol, 2009 Jul 18; 10(10). PMID: 19609254    Free PMC article.
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Cancer, 2005 Feb 05; 103(6). PMID: 15693021
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The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.
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Nature, 2007 Sep 28; 449(7161). PMID: 17898760
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Nat Immunol, 2001 Feb 27; 2(3). PMID: 11224527
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Immunity, 2011 Jul 26; 35(2). PMID: 21782478    Free PMC article.
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J Exp Med, 2013 Nov 28; 210(13). PMID: 24277153    Free PMC article.
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Immunity, 2012 Dec 19; 38(1). PMID: 23246311    Free PMC article.
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CD40-targeted adenoviral gene transfer to dendritic cells through the use of a novel bispecific single-chain Fv antibody enhances cytotoxic T cell activation.
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Vaccine, 2003 May 15; 21(19-20). PMID: 12744857
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Nat Rev Immunol, 2016 Jun 14; 16(7). PMID: 27291964
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Isabell A Pfeiffer, Stefanie Hoyer, +6 authors, Jan Dörrie.
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Nature, 2016 Jan 28; 530(7590). PMID: 26814970    Free PMC article.
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J Immunol, 2014 Nov 12; 193(12). PMID: 25385820    Free PMC article.
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Immunity, 2002 Oct 02; 17(3). PMID: 12354387
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Cell Rep, 2015 Dec 17; 13(11). PMID: 26670049
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J Exp Med, 2002 Dec 18; 196(12). PMID: 12486105    Free PMC article.
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J Immunol, 2014 Oct 17; 193(10). PMID: 25320273    Free PMC article.
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Nat Immunol, 2001 Mar 23; 1(5). PMID: 11062504
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Trends Mol Med, 2006 Mar 15; 12(4). PMID: 16530484
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Intestinal CD103+CD11b+ cDC2 Conventional Dendritic Cells Are Required for Primary CD4+ T and B Cell Responses to Soluble Flagellin.
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Nat Immunol, 2003 Oct 28; 4(12). PMID: 14578884
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Highly Cited. Review.
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Highly Cited. Review.
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Blood, 2009 Dec 17; 115(8). PMID: 20009034
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