Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. E Li, T H Bestor, R Jaenisch. Cell, 1992 Jun 12; 69(6). PMID: 1606615 Highly Cited.
|
Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis. Ruili Yang, Cunye Qu, +11 authors, Yu Zhou, Joanne E Konkel, Shihong Shi, Yi Liu, Chider Chen, Shiyu Liu, Dawei Liu, Yibu Chen, Ebrahim Zandi, Wanjun Chen, Yanheng Zhou, Songtao Shi. less Immunity, 2015 Aug 16; 43(2). PMID: 26275994 Free PMC article. Highly Cited.
|
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky. Nat Immunol, 2003 Mar 04; 4(4). PMID: 12612578 Highly Cited.
|
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Naganari Ohkura, Masahide Hamaguchi, +12 authors, Hiromasa Morikawa, Kyoko Sugimura, Atsushi Tanaka, Yoshinaga Ito, Motonao Osaki, Yoshiaki Tanaka, Riu Yamashita, Naoko Nakano, Jochen Huehn, Hans Joerg Fehling, Tim Sparwasser, Kenta Nakai, Shimon Sakaguchi. less Immunity, 2012 Nov 06; 37(5). PMID: 23123060 Highly Cited.
|
KLRG1 expression identifies short-lived Foxp3+ Treg effector cells with functional plasticity in islets of NOD mice. Mara Kornete, Edward Mason, Roman Istomine, Ciriaco A Piccirillo. Autoimmunity, 2017 Aug 30; 50(6). PMID: 28850267
|
DNA Methyltransferase Inhibitor Promotes Human CD4+CD25hFOXP3+ Regulatory T Lymphocyte Induction under Suboptimal TCR Stimulation. Chun-Hao Lu, Cheng-Jang Wu, +6 authors, Cheng-Chi Chan, Duc T Nguyen, Kuo-Ray Lin, Syh-Jae Lin, Li-Chen Chen, Jeffrey Jong-Yong Yen, Ming-Ling Kuo. less Front Immunol, 2016 Nov 24; 7. PMID: 27877174 Free PMC article.
|
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Takahisa Miyao, Stefan Floess, +5 authors, Ruka Setoguchi, Hervé Luche, Hans Joerg Fehling, Herman Waldmann, Jochen Huehn, Shohei Hori. less Immunity, 2012 Feb 14; 36(2). PMID: 22326580 Highly Cited.
|
A Practical Guide to the Measurement and Analysis of DNA Methylation. Benjamin D Singer. Am J Respir Cell Mol Biol, 2019 Jul 03; 61(4). PMID: 31264905 Free PMC article.
|
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Yuri P Rubtsov, Jeffrey P Rasmussen, +9 authors, Emil Y Chi, Jason Fontenot, Luca Castelli, Xin Ye, Piper Treuting, Lisa Siewe, Axel Roers, William R Henderson, Werner Muller, Alexander Y Rudensky. less Immunity, 2008 Apr 05; 28(4). PMID: 18387831 Highly Cited.
|
Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report. Robert M Tighe, Elizabeth F Redente, +13 authors, Yen-Rei Yu, Susanne Herold, Anne I Sperling, Jeffrey L Curtis, Ryan Duggan, Suchitra Swaminathan, Hideki Nakano, William J Zacharias, William J Janssen, Christine M Freeman, Ryan R Brinkman, Benjamin D Singer, Claudia V Jakubzick, Alexander V Misharin. less Am J Respir Cell Mol Biol, 2019 Aug 02; 61(2). PMID: 31368812 Free PMC article.
|
Regulatory T cells: mechanisms of differentiation and function. Steven Z Josefowicz, Li-Fan Lu, Alexander Y Rudensky. Annu Rev Immunol, 2012 Jan 10; 30. PMID: 22224781 Free PMC article. Highly Cited. Review.
|
Low-dose 5-aza-2'-deoxycytidine pretreatment inhibits experimental autoimmune encephalomyelitis by induction of regulatory T cells. Michael W Y Chan, Chia-Bin Chang, +3 authors, Chien-Hsueh Tung, Justin Sun, Jau-Ling Suen, Shu-Fen Wu. less Mol Med, 2014 May 30; 20. PMID: 24869907 Free PMC article.
|
Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties. Xiangqian Kong, Jie Chen, +15 authors, Wenbing Xie, Stephen M Brown, Yi Cai, Kaichun Wu, Daiming Fan, Yongzhan Nie, Srinivasan Yegnasubramanian, Rochelle L Tiedemann, Yong Tao, Ray-Whay Chiu Yen, Michael J Topper, Cynthia A Zahnow, Hariharan Easwaran, Scott B Rothbart, Limin Xia, Stephen B Baylin. less Cancer Cell, 2019 Apr 09; 35(4). PMID: 30956060 Free PMC article.
|
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Jafar Sharif, Masahiro Muto, +11 authors, Shin-ichiro Takebayashi, Isao Suetake, Akihiro Iwamatsu, Takaho A Endo, Jun Shinga, Yoko Mizutani-Koseki, Tetsuro Toyoda, Kunihiro Okamura, Shoji Tajima, Kohzoh Mitsuya, Masaki Okano, Haruhiko Koseki. less Nature, 2007 Nov 13; 450(7171). PMID: 17994007 Highly Cited.
|
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Xuyu Zhou, Samantha L Bailey-Bucktrout, +6 authors, Lukas T Jeker, Cristina Penaranda, Marc Martínez-Llordella, Meredith Ashby, Maki Nakayama, Wendy Rosenthal, Jeffrey A Bluestone. less Nat Immunol, 2009 Jul 28; 10(9). PMID: 19633673 Free PMC article. Highly Cited.
|
The Mouse Genome Database genotypes::phenotypes. Judith A Blake, Carol J Bult, +3 authors, Janan T Eppig, James A Kadin, Joel E Richardson, Mouse Genome Database Group. less Nucleic Acids Res, 2008 Nov 05; 37(Database issue). PMID: 18981050 Free PMC article.
|
Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation. Jernej Godec, Yan Tan, +5 authors, Arthur Liberzon, Pablo Tamayo, Sanchita Bhattacharya, Atul J Butte, Jill P Mesirov, W Nicholas Haining. less Immunity, 2016 Jan 23; 44(1). PMID: 26795250 Free PMC article. Highly Cited.
|
CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. Hyoung-Pyo Kim, Warren J Leonard. J Exp Med, 2007 Jun 27; 204(7). PMID: 17591856 Free PMC article. Highly Cited.
|
S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance. Jiqin Zhang, Qinqin Gao, +7 authors, Pishun Li, Xiaoli Liu, Yuanhui Jia, Weicheng Wu, Jiwen Li, Shuo Dong, Haruhiko Koseki, Jiemin Wong. less Cell Res, 2011 Nov 09; 21(12). PMID: 22064703 Free PMC article.
|
CoRESTed development of regulatory T cells. Luisa Morales-Nebreda, Kathryn A Helmin, Benjamin D Singer. J Clin Invest, 2020 Mar 04; 130(4). PMID: 32125289 Free PMC article.
|
Global natural regulatory T cell depletion in active systemic lupus erythematosus. Makoto Miyara, Zahir Amoura, +7 authors, Christophe Parizot, Cécile Badoual, Karim Dorgham, Salim Trad, Dominique Nochy, Patrice Debré, Jean-Charles Piette, Guy Gorochov. less J Immunol, 2005 Dec 13; 175(12). PMID: 16339581 Highly Cited.
|
The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells. Yuuki Obata, Yukihiro Furusawa, +19 authors, Takaho A Endo, Jafar Sharif, Daisuke Takahashi, Koji Atarashi, Manabu Nakayama, Satoshi Onawa, Yumiko Fujimura, Masumi Takahashi, Tomokatsu Ikawa, Takeshi Otsubo, Yuki I Kawamura, Taeko Dohi, Shoji Tajima, Hiroshi Masumoto, Osamu Ohara, Kenya Honda, Shohei Hori, Hiroshi Ohno, Haruhiko Koseki, Koji Hase. less Nat Immunol, 2014 Apr 30; 15(6). PMID: 24777532 Highly Cited.
|
Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases. Naganari Ohkura, Yoshiaki Yasumizu, +6 authors, Yohko Kitagawa, Atsushi Tanaka, Yamami Nakamura, Daisuke Motooka, Shota Nakamura, Yukinori Okada, Shimon Sakaguchi. less Immunity, 2020 May 05; 52(6). PMID: 32362325
|
DNA methylation controls Foxp3 gene expression. Julia K Polansky, Karsten Kretschmer, +7 authors, Jennifer Freyer, Stefan Floess, Annette Garbe, Udo Baron, Sven Olek, Alf Hamann, Harald von Boehmer, Jochen Huehn. less Eur J Immunol, 2008 May 22; 38(6). PMID: 18493985 Highly Cited.
|
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. Alexander V Misharin, Luisa Morales-Nebreda, +40 authors, Paul A Reyfman, Carla M Cuda, James M Walter, Alexandra C McQuattie-Pimentel, Ching-I Chen, Kishore R Anekalla, Nikita Joshi, Kinola J N Williams, Hiam Abdala-Valencia, Tyrone J Yacoub, Monica Chi, Stephen Chiu, Francisco J Gonzalez-Gonzalez, Khalilah Gates, Anna P Lam, Trevor T Nicholson, Philip J Homan, Saul Soberanes, Salina Dominguez, Vince K Morgan, Rana Saber, Alexander Shaffer, Monique Hinchcliff, Stacy A Marshall, Ankit Bharat, Sergejs Berdnikovs, Sangeeta M Bhorade, Elizabeth T Bartom, Richard I Morimoto, William E Balch, Jacob I Sznajder, Navdeep S Chandel, Gökhan M Mutlu, Manu Jain, Cara J Gottardi, Benjamin D Singer, Karen M Ridge, Neda Bagheri, Ali Shilatifard, G R Scott Budinger, Harris Perlman. less J Exp Med, 2017 Jul 12; 214(8). PMID: 28694385 Free PMC article. Highly Cited.
|
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. Girdhari Lal, Nan Zhang, +6 authors, William van der Touw, Yaozhong Ding, Wenjun Ju, Erwin P Bottinger, St Patrick Reid, David E Levy, Jonathan S Bromberg. less J Immunol, 2008 Dec 26; 182(1). PMID: 19109157 Free PMC article. Highly Cited.
|
Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Robert M Samstein, Aaron Arvey, +11 authors, Steven Z Josefowicz, Xiao Peng, Alex Reynolds, Richard Sandstrom, Shane Neph, Peter Sabo, Jeong M Kim, Will Liao, Ming O Li, Christina Leslie, John A Stamatoyannopoulos, Alexander Y Rudensky. less Cell, 2012 Oct 02; 151(1). PMID: 23021222 Free PMC article. Highly Cited.
|
Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation. Benjamin D Singer, Jason R Mock, +10 authors, Neil R Aggarwal, Brian T Garibaldi, Venkataramana K Sidhaye, Marcus A Florez, Eric Chau, Kevin W Gibbs, Pooja Mandke, Ashutosh Tripathi, Srinivasan Yegnasubramanian, Landon S King, Franco R D'Alessio. less Am J Respir Cell Mol Biol, 2014 Oct 09; 52(5). PMID: 25295995 Free PMC article.
|
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis. Sarah L May, Qing Zhou, +12 authors, Mitzi Lewellen, Cristan M Carter, David Coffey, Steven L Highfill, Christoph M Bucher, Ilze Matise, Herbert C Morse, M Gerard O'Sullivan, Melissa Schutten, Charles Johnson, Donald Bellgrau, Bruce R Blazar, Jaime F Modiano. less PLoS One, 2014 Jun 20; 9(6). PMID: 24945807 Free PMC article.
|
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. M E Brunkow, E W Jeffery, +7 authors, K A Hjerrild, B Paeper, L B Clark, S A Yasayko, J E Wilkinson, D Galas, S F Ziegler, F Ramsdell. less Nat Genet, 2001 Jan 04; 27(1). PMID: 11138001 Highly Cited.
|
TCR stimulation upregulates MS4a4B expression through induction of AP-1 transcription factor during T cell activation. Yaping Yan, Guang-Xian Zhang, +5 authors, Mark S Williams, Gregory B Carey, Hongmei Li, Jingxian Yang, Abdolmohamad Rostami, Hui Xu. less Mol Immunol, 2012 May 19; 52(2). PMID: 22595231 Free PMC article.
|
Regulatory T cells and immune tolerance. Shimon Sakaguchi, Tomoyuki Yamaguchi, Takashi Nomura, Masahiro Ono. Cell, 2008 May 31; 133(5). PMID: 18510923 Highly Cited. Review.
|
Stability of the regulatory T cell lineage in vivo. Yuri P Rubtsov, Rachel E Niec, +5 authors, Steven Josefowicz, Li Li, Jaime Darce, Diane Mathis, Christophe Benoist, Alexander Y Rudensky. less Science, 2010 Oct 12; 329(5999). PMID: 20929851 Free PMC article. Highly Cited.
|
Epigenetic mechanisms of regulation of Foxp3 expression. Girdhari Lal, Jonathan S Bromberg. Blood, 2009 Jul 31; 114(18). PMID: 19641188 Free PMC article. Highly Cited. Review.
|
Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment. Yohko Kitagawa, Naganari Ohkura, +10 authors, Yujiro Kidani, Alexis Vandenbon, Keiji Hirota, Ryoji Kawakami, Keiko Yasuda, Daisuke Motooka, Shota Nakamura, Motonari Kondo, Ichiro Taniuchi, Terumi Kohwi-Shigematsu, Shimon Sakaguchi. less Nat Immunol, 2016 Dec 20; 18(2). PMID: 27992401 Free PMC article. Highly Cited.
|
Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. Xavier Valencia, Cheryl Yarboro, Gabor Illei, Peter E Lipsky. J Immunol, 2007 Feb 06; 178(4). PMID: 17277168 Highly Cited.
|
Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication. Atsuya Nishiyama, Luna Yamaguchi, +9 authors, Jafar Sharif, Yoshikazu Johmura, Takeshi Kawamura, Keiko Nakanishi, Shintaro Shimamura, Kyohei Arita, Tatsuhiko Kodama, Fuyuki Ishikawa, Haruhiko Koseki, Makoto Nakanishi. less Nature, 2013 Sep 10; 502(7470). PMID: 24013172 Highly Cited.
|
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Jonathan A Hill, Markus Feuerer, +5 authors, Kaley Tash, Sokol Haxhinasto, Jasmine Perez, Rachel Melamed, Diane Mathis, Christophe Benoist. less Immunity, 2007 Nov 21; 27(5). PMID: 18024188 Highly Cited.
|
Requirements for growth and IL-10 expression of highly purified human T regulatory cells. Benedetta Bonacci, Brandon Edwards, +4 authors, Shuang Jia, Calvin B Williams, Martin J Hessner, Stephen B Gauld, James W Verbsky. less J Clin Immunol, 2012 May 09; 32(5). PMID: 22562448 Free PMC article.
|
Flow-cytometric method for simultaneous analysis of mouse lung epithelial, endothelial, and hematopoietic lineage cells. Benjamin D Singer, Jason R Mock, +4 authors, Franco R D'Alessio, Neil R Aggarwal, Pooja Mandke, Laura Johnston, Mahendra Damarla. less Am J Physiol Lung Cell Mol Physiol, 2016 Mar 06; 310(9). PMID: 26944088 Free PMC article.
|
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. M S Jordan, A Boesteanu, +5 authors, A J Reed, A L Petrone, A E Holenbeck, M A Lerman, A Naji, A J Caton. less Nat Immunol, 2001 Mar 29; 2(4). PMID: 11276200 Highly Cited.
|
TET2 coactivates gene expression through demethylation of enhancers. Lu Wang, Patrick A Ozark, +11 authors, Edwin R Smith, Zibo Zhao, Stacy A Marshall, Emily J Rendleman, Andrea Piunti, Caila Ryan, Anna L Whelan, Kathryn A Helmin, Marc Alard Morgan, Lihua Zou, Benjamin D Singer, Ali Shilatifard. less Sci Adv, 2018 Nov 13; 4(11). PMID: 30417100 Free PMC article.
|
DNA methylation and gene expression signatures are associated with ataxia-telangiectasia phenotype. Sharon A McGrath-Morrow, Roland Ndeh, +7 authors, Kathryn A Helmin, Basil Khuder, Cynthia Rothblum-Oviatt, Joseph M Collaco, Jennifer Wright, Paul A Reyfman, Howard M Lederman, Benjamin D Singer. less Sci Rep, 2020 May 06; 10(1). PMID: 32366930 Free PMC article.
|
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. R S Wildin, F Ramsdell, +13 authors, J Peake, F Faravelli, J L Casanova, N Buist, E Levy-Lahad, M Mazzella, O Goulet, L Perroni, F D Bricarelli, G Byrne, M McEuen, S Proll, M Appleby, M E Brunkow. less Nat Genet, 2001 Jan 04; 27(1). PMID: 11137992 Highly Cited.
|
Multidimensional assessment of alveolar T cells in critically ill patients. James M Walter, Kathryn A Helmin, +2 authors, Hiam Abdala-Valencia, Richard G Wunderink, Benjamin D Singer. less JCI Insight, 2018 Sep 07; 3(17). PMID: 30185658 Free PMC article.
|
Development and maintenance of regulatory T cells. Naganari Ohkura, Yohko Kitagawa, Shimon Sakaguchi. Immunity, 2013 Mar 26; 38(3). PMID: 23521883 Highly Cited. Review.
|
Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos. Shoji Maenohara, Motoko Unoki, +4 authors, Hidehiro Toh, Hiroaki Ohishi, Jafar Sharif, Haruhiko Koseki, Hiroyuki Sasaki. less PLoS Genet, 2017 Oct 05; 13(10). PMID: 28976982 Free PMC article.
|
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, +8 authors, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov. less Proc Natl Acad Sci U S A, 2005 Oct 04; 102(43). PMID: 16199517 Free PMC article. Highly Cited.
|
CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases. Xavier Valencia, Peter E Lipsky. Nat Clin Pract Rheumatol, 2007 Oct 31; 3(11). PMID: 17968332 Review.
|
Azacytidine Treatment Inhibits the Progression of Herpes Stromal Keratitis by Enhancing Regulatory T Cell Function. Siva Karthik Varanasi, Pradeep B J Reddy, +3 authors, Siddheshvar Bhela, Ujjaldeep Jaggi, Fernanda Gimenez, Barry T Rouse. less J Virol, 2017 Jan 20; 91(7). PMID: 28100624 Free PMC article.
|
A distinct subpopulation of CD25- T-follicular regulatory cells localizes in the germinal centers. James Badger Wing, Yohko Kitagawa, +11 authors, Michela Locci, Hannah Hume, Christopher Tay, Takayoshi Morita, Yujiro Kidani, Kyoko Matsuda, Takeshi Inoue, Tomohiro Kurosaki, Shane Crotty, Cevayir Coban, Naganari Ohkura, Shimon Sakaguchi. less Proc Natl Acad Sci U S A, 2017 Jul 13; 114(31). PMID: 28698369 Free PMC article. Highly Cited.
|
GREAT improves functional interpretation of cis-regulatory regions. Cory Y McLean, Dave Bristor, +5 authors, Michael Hiller, Shoa L Clarke, Bruce T Schaar, Craig B Lowe, Aaron M Wenger, Gill Bejerano. less Nat Biotechnol, 2010 May 04; 28(5). PMID: 20436461 Free PMC article. Highly Cited.
|
Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity. Liqing Wang, Yujie Liu, +4 authors, Ulf H Beier, Rongxiang Han, Tricia R Bhatti, Tatiana Akimova, Wayne W Hancock. less Blood, 2013 Feb 28; 121(18). PMID: 23444399 Free PMC article.
|
CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism. Andrea Piunti, Edwin R Smith, +12 authors, Marc A J Morgan, Michal Ugarenko, Natalia Khaltyan, Kathryn A Helmin, Caila A Ryan, David C Murray, Ryan A Rickels, Bahar D Yilmaz, Emily J Rendleman, Jeffrey N Savas, Benjamin D Singer, Serdar E Bulun, Ali Shilatifard. less Sci Adv, 2019 Jul 10; 5(7). PMID: 31281901 Free PMC article.
|
DNA methylation regulates the neonatal CD4+ T-cell response to pneumonia in mice. Sharon A McGrath-Morrow, Roland Ndeh, +6 authors, Kathryn A Helmin, Shang-Yang Chen, Kishore R Anekalla, Hiam Abdala-Valencia, Franco R D'Alessio, J Michael Collaco, Benjamin D Singer. less J Biol Chem, 2018 Jun 06; 293(30). PMID: 29866884 Free PMC article.
|
Quantification of regulatory T cells in patients with systemic lupus erythematosus. Jose C Crispin, Araceli Martínez, Jorge Alcocer-Varela. J Autoimmun, 2003 Nov 06; 21(3). PMID: 14599852 Highly Cited.
|
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. Tyler R Simpson, Fubin Li, +11 authors, Welby Montalvo-Ortiz, Manuel A Sepulveda, Katharina Bergerhoff, Frederick Arce, Claire Roddie, Jake Y Henry, Hideo Yagita, Jedd D Wolchok, Karl S Peggs, Jeffrey V Ravetch, James P Allison, Sergio A Quezada. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981 Free PMC article. Highly Cited.
|
The DNA methylation inhibitor 5-azacytidine increases regulatory T cells and alleviates airway inflammation in ovalbumin-sensitized mice. Cheng-Jang Wu, Chin-Yu Yang, +3 authors, Yi-Hsin Chen, Chun-Ming Chen, Li-Chen Chen, Ming-Ling Kuo. less Int Arch Allergy Immunol, 2012 Nov 28; 160(4). PMID: 23183158
|
Regulatory T cells as immunotherapy. Benjamin D Singer, Landon S King, Franco R D'Alessio. Front Immunol, 2014 Feb 28; 5. PMID: 24575095 Free PMC article. Highly Cited. Review.
|
The blockade of immune checkpoints in cancer immunotherapy. Drew M Pardoll. Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437870 Free PMC article. Highly Cited. Review.
|
DNA methylation as a transcriptional regulator of the immune system. Luisa Morales-Nebreda, Fred S McLafferty, Benjamin D Singer. Transl Res, 2018 Sep 01; 204. PMID: 30170004 Free PMC article. Review.
|
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. Karl S Peggs, Sergio A Quezada, +2 authors, Cynthia A Chambers, Alan J Korman, James P Allison. less J Exp Med, 2009 Jul 08; 206(8). PMID: 19581407 Free PMC article. Highly Cited.
|
Systemic lupus erythematosus-associated diffuse alveolar hemorrhage: A case report and review of the literature. Luisa Morales-Nebreda, Omolola Alakija, Keith T Ferguson, Benjamin D Singer. Clin Pulm Med, 2018 Sep 18; 25(5). PMID: 30220838 Free PMC article.
|
Two missense variants in UHRF1BP1 are independently associated with systemic lupus erythematosus in Hong Kong Chinese. Y Zhang, W Yang, +20 authors, C C Mok, T M Chan, R W S Wong, M Y Mok, K W Lee, S N Wong, A M H Leung, T L Lee, M H K Ho, P P W Lee, W H S Wong, J Yang, J Zhang, C-M Wong, I O L Ng, M-M Garcia-Barceló, S S Cherny, P K-H Tam, P C Sham, C S Lau, Y L Lau. less Genes Immun, 2011 Feb 18; 12(3). PMID: 21326321
|
TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity. Xiang Sun, Yu Cui, +2 authors, Haiyun Feng, Haifeng Liu, Xiaolong Liu. less J Exp Med, 2019 Sep 14; 216(12). PMID: 31515281 Free PMC article.
|
Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea. E Antiga, P Quaglino, +9 authors, S Bellandi, W Volpi, E Del Bianco, A Comessatti, S Osella-Abate, C De Simone, A Marzano, M G Bernengo, P Fabbri, M Caproni. less Br J Dermatol, 2010 Jan 29; 162(5). PMID: 20105169
|
Inflammation and transcriptional responses of peripheral blood mononuclear cells in classic ataxia telangiectasia. Sharon A McGrath-Morrow, Roland Ndeh, +5 authors, Joseph M Collaco, Cynthia Rothblum-Oviatt, Jennifer Wright, Michael A O'Reilly, Benjamin D Singer, Howard M Lederman. less PLoS One, 2018 Dec 27; 13(12). PMID: 30586396 Free PMC article.
|
UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Magnolia Bostick, Jong Kyong Kim, +3 authors, Pierre-Olivier Estève, Amander Clark, Sriharsa Pradhan, Steven E Jacobsen. less Science, 2007 Aug 04; 317(5845). PMID: 17673620 Highly Cited.
|
Mitochondrial complex III is essential for suppressive function of regulatory T cells. Samuel E Weinberg, Benjamin D Singer, +10 authors, Elizabeth M Steinert, Carlos A Martinez, Manan M Mehta, Inmaculada Martínez-Reyes, Peng Gao, Kathryn A Helmin, Hiam Abdala-Valencia, Laura A Sena, Paul T Schumacker, Laurence A Turka, Navdeep S Chandel. less Nature, 2019 Jan 11; 565(7740). PMID: 30626970 Free PMC article. Highly Cited.
|
Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection. Alison Crawford, Jill M Angelosanto, +4 authors, Charlly Kao, Travis A Doering, Pamela M Odorizzi, Burton E Barnett, E John Wherry. less Immunity, 2014 Feb 18; 40(2). PMID: 24530057 Free PMC article. Highly Cited.
|