Comparison of the Performance of 6 Prognostic Signatures for Estrogen Receptor-Positive Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial.
Ivana Sestak, Richard Buus, +9 authors, Jack Cuzick, Peter Dubsky, Ralf Kronenwett, Carsten Denkert, Sean Ferree, Dennis Sgroi, Catherine Schnabel, Frederick L Baehner, Elizabeth Mallon, Mitch Dowsett. less
JAMA Oncol, 2018 Feb 17; 4(4). PMID: 29450494 Free PMC article.
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Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers.
Giampaolo Bianchini, Lajos Pusztai, +16 authors, Thomas Karn, Takayuki Iwamoto, Achim Rody, Catherine Kelly, Volkmar Müller, Schmidt Schmidt, Yuan Qi, Uwe Holtrich, Sven Becker, Libero Santarpia, Angelica Fasolo, Gianluca Del Conte, Milvia Zambetti, Christos Sotiriou, Benjamin Haibe-Kains, W Fraser Symmans, Luca Gianni. less
Breast Cancer Res, 2013 Sep 26; 15(5). PMID: 24060333 Free PMC article.
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Early discontinuation of tamoxifen: a lesson for oncologists.
Thomas I Barron, Róisín Connolly, +2 authors, Kathleen Bennett, John Feely, M John Kennedy. less
Cancer, 2007 Jan 24; 109(5). PMID: 17243168
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Adjuvant Letrozole and Tamoxifen Alone or Sequentially for Postmenopausal Women With Hormone Receptor-Positive Breast Cancer: Long-Term Follow-Up of the BIG 1-98 Trial.
Thomas Ruhstaller, Anita Giobbie-Hurder, +27 authors, Marco Colleoni, Maj-Britt Jensen, Bent Ejlertsen, Evandro de Azambuja, Patrick Neven, István Láng, Erik Hugger Jakobsen, Laurence Gladieff, Hervé Bonnefoi, Vernon J Harvey, Simon Spazzapan, Carlo Tondini, Lucia Del Mastro, Corinne Veyret, Edda Simoncini, Lorenzo Gianni, Christoph Rochlitz, Elena Kralidis, Khalil Zaman, Jacek Jassem, Martine Piccart-Gebhart, Angelo Di Leo, Richard D Gelber, Alan S Coates, Aron Goldhirsch, Beat Thürlimann, Meredith M Regan, members of the BIG 1-98 Collaborative Group and the International Breast Cancer Study Group. less
J Clin Oncol, 2018 Nov 27; 37(2). PMID: 30475668 Free PMC article.
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Optimal Duration of Extended Adjuvant Endocrine Therapy for Early Breast Cancer; Results of the IDEAL Trial (BOOG 2006-05).
Erik J Blok, Judith R Kroep, +10 authors, Elma Meershoek-Klein Kranenbarg, Marjolijn Duijm-de Carpentier, Hein Putter, Joan van den Bosch, Eduard Maartense, A Elise van Leeuwen-Stok, Gerrit-Jan Liefers, Johan W R Nortier, Emiel J Th Rutgers, Cornelis J H van de Velde, IDEAL Study Group. less
J Natl Cancer Inst, 2017 Sep 20; 110(1). PMID: 28922787
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Ki67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance).
Matthew J Ellis, Vera J Suman, +28 authors, Jeremy Hoog, Rodrigo Goncalves, Souzan Sanati, Chad J Creighton, Katherine DeSchryver, Erika Crouch, Amy Brink, Mark Watson, Jingqin Luo, Yu Tao, Michael Barnes, Mitchell Dowsett, G Thomas Budd, Eric Winer, Paula Silverman, Laura Esserman, Lisa Carey, Cynthia X Ma, Gary Unzeitig, Timothy Pluard, Pat Whitworth, Gildy Babiera, J Michael Guenther, Zoneddy Dayao, David Ota, Marilyn Leitch, John A Olson, D Craig Allred, Kelly Hunt. less
J Clin Oncol, 2017 Jan 04; 35(10). PMID: 28045625 Free PMC article.
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Outcomes in women with invasive ductal or invasive lobular early stage breast cancer treated with anastrozole or exemestane in CCTG (NCIC CTG) MA.27.
K Strasser-Weippl, G Sudan, +6 authors, R Ramjeesingh, L E Shepherd, J O'Shaughnessy, W R Parulekar, P E R Liedke, B E Chen, P E Goss. less
Eur J Cancer, 2017 Dec 24; 90. PMID: 29274617
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Prospective assessment of the decision-making impact of the Breast Cancer Index in recommending extended adjuvant endocrine therapy for patients with early-stage ER-positive breast cancer.
Tara Sanft, Bilge Aktas, +11 authors, Brock Schroeder, Veerle Bossuyt, Michael DiGiovanna, Maysa Abu-Khalaf, Gina Chung, Andrea Silber, Erin Hofstatter, Sarah Mougalian, Lianne Epstein, Christos Hatzis, Cathy Schnabel, Lajos Pusztai. less
Breast Cancer Res Treat, 2015 Nov 19; 154(3). PMID: 26578401 Free PMC article.
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Treatment Efficacy, Adherence, and Quality of Life Among Women Younger Than 35 Years in the International Breast Cancer Study Group TEXT and SOFT Adjuvant Endocrine Therapy Trials.
Poornima Saha, Meredith M Regan, +25 authors, Olivia Pagani, Prudence A Francis, Barbara A Walley, Karin Ribi, Jürg Bernhard, Weixiu Luo, Henry L Gómez, Harold J Burstein, Vani Parmar, Roberto Torres, Josephine Stewart, Meritxell Bellet, Antonia Perelló, Faysal Dane, Antonio Moreira, Daniel Vorobiof, Michelle Nottage, Karen N Price, Alan S Coates, Aron Goldhirsch, Richard D Gelber, Marco Colleoni, Gini F Fleming, SOFT, TEXT Investigators, International Breast Cancer Study Group. less
J Clin Oncol, 2017 Jun 28; 35(27). PMID: 28654365 Free PMC article.
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The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)-Endoxifen in Breast Cancer.
Jeanine Marie Nardin, Werner Schroth, +11 authors, Thais Abreu Almeida, Thomas Mürdter, Solane Picolotto, Evelyn Castillo Lima Vendramini, Reiner Hoppe, Jenifer Primon Kogin, Diandra Miqueleto, Silvia Dark Robaskievicz de Moraes, Matthias Schwab, Roberto Flavio Pecoits-Filho, Hiltrud Brauch, José Claudio Casali-da-Rocha. less
Clin Transl Sci, 2019 Oct 02; 13(2). PMID: 31573754 Free PMC article.
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Toxicity of adjuvant endocrine therapy in postmenopausal breast cancer patients: a systematic review and meta-analysis.
Eitan Amir, Bostjan Seruga, +2 authors, Saroj Niraula, Lindsay Carlsson, Alberto Ocaña. less
J Natl Cancer Inst, 2011 Jul 12; 103(17). PMID: 21743022
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Integration of Clinical Variables for the Prediction of Late Distant Recurrence in Patients With Estrogen Receptor-Positive Breast Cancer Treated With 5 Years of Endocrine Therapy: CTS5.
Mitch Dowsett, Ivana Sestak, +5 authors, Meredith M Regan, Andrew Dodson, Giuseppe Viale, Beat Thürlimann, Marco Colleoni, Jack Cuzick. less
J Clin Oncol, 2018 Apr 21; 36(19). PMID: 29676944 Free PMC article.
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Extended adjuvant aromatase inhibition after sequential endocrine therapy (DATA): a randomised, phase 3 trial.
Vivianne C G Tjan-Heijnen, Irene E G van Hellemond, +14 authors, Petronella G M Peer, Astrid C P Swinkels, Carolien H Smorenburg, Maurice J C van der Sangen, Judith R Kroep, Hiltje De Graaf, Aafke H Honkoop, Frans L G Erdkamp, Franchette W P J van den Berkmortel, Maaike de Boer, Wilfred K de Roos, Sabine C Linn, Alexander L T Imholz, Caroline M Seynaeve, Dutch Breast Cancer Research Group (BOOG) for the DATA Investigators. less
Lancet Oncol, 2017 Oct 17; 18(11). PMID: 29031778
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Evaluating the 21-gene assay Recurrence Score® as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer.
Takayuki Ueno, Norikazu Masuda, +12 authors, Takeharu Yamanaka, Shigehira Saji, Katsumasa Kuroi, Nobuaki Sato, Hiroyuki Takei, Yutaka Yamamoto, Shinji Ohno, Hiroko Yamashita, Kazufumi Hisamatsu, Kenjiro Aogi, Hiroji Iwata, Hironobu Sasano, Masakazu Toi. less
Int J Clin Oncol, 2013 Oct 09; 19(4). PMID: 24101215
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Absolute Benefit of Adjuvant Endocrine Therapies for Premenopausal Women With Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Early Breast Cancer: TEXT and SOFT Trials.
Meredith M Regan, Prudence A Francis, +12 authors, Olivia Pagani, Gini F Fleming, Barbara A Walley, Giuseppe Viale, Marco Colleoni, István Láng, Henry L Gómez, Carlo Tondini, Graziella Pinotti, Karen N Price, Alan S Coates, Aron Goldhirsch, Richard D Gelber. less
J Clin Oncol, 2016 Apr 06; 34(19). PMID: 27044936 Free PMC article.
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Benefit from exemestane as extended adjuvant therapy after 5 years of adjuvant tamoxifen: intention-to-treat analysis of the National Surgical Adjuvant Breast And Bowel Project B-33 trial.
Eleftherios P Mamounas, Jong-Hyeon Jeong, +17 authors, D Lawrence Wickerham, Roy E Smith, Patricia A Ganz, Stephanie R Land, Andrea Eisen, Louis Fehrenbacher, William B Farrar, James N Atkins, Eduardo R Pajon, Victor G Vogel, Joan F Kroener, Laura F Hutchins, André Robidoux, James L Hoehn, James N Ingle, Charles E Geyer, Joseph P Costantino, Norman Wolmark. less
J Clin Oncol, 2008 Mar 12; 26(12). PMID: 18332472
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Adjuvant ovarian suppression in premenopausal breast cancer.
Prudence A Francis, Meredith M Regan, +28 authors, Gini F Fleming, István Láng, Eva Ciruelos, Meritxell Bellet, Hervé R Bonnefoi, Miguel A Climent, Gian Antonio Da Prada, Harold J Burstein, Silvana Martino, Nancy E Davidson, Charles E Geyer, Barbara A Walley, Robert Coleman, Pierre Kerbrat, Stefan Buchholz, James N Ingle, Eric P Winer, Manuela Rabaglio-Poretti, Rudolf Maibach, Barbara Ruepp, Anita Giobbie-Hurder, Karen N Price, Marco Colleoni, Giuseppe Viale, Alan S Coates, Aron Goldhirsch, Richard D Gelber, SOFT Investigators, International Breast Cancer Study Group. less
N Engl J Med, 2014 Dec 17; 372(5). PMID: 25495490 Free PMC article.
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Adding Ovarian Suppression to Tamoxifen for Premenopausal Breast Cancer: A Randomized Phase III Trial.
Hyun-Ah Kim, Jong Won Lee, +27 authors, Seok Jin Nam, Byeong-Woo Park, Seock-Ah Im, Eun Sook Lee, Yong Sik Jung, Jung Han Yoon, Sung Soo Kang, Soo-Jung Lee, Kyong Hwa Park, Joon Jeong, Se-Heon Cho, Sung Yong Kim, Lee Su Kim, Byung-In Moon, Min Hyuk Lee, Tae Hyun Kim, Chanheun Park, Sung Hoo Jung, Geumhee Gwak, Jeryong Kim, Sun Hee Kang, Young Woo Jin, Hee Jeong Kim, Se-Hwan Han, Wonshik Han, Min Hee Hur, Woo Chul Noh, Korean Breast Cancer Study Group. less
J Clin Oncol, 2019 Sep 14; 38(5). PMID: 31518174
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Ovarian Function Recovery During Anastrozole in Breast Cancer Patients With Chemotherapy-Induced Ovarian Function Failure.
Irene E G van Hellemond, Ingeborg J H Vriens, +16 authors, Petronella G M Peer, Astrid C P Swinkels, Carolien H Smorenburg, Caroline M Seynaeve, Maurice J C van der Sangen, Judith R Kroep, Hiltje de Graaf, Aafke H Honkoop, Frans L G Erdkamp, Franchette W P J van den Berkmortel, Jos J E M Kitzen, Maaike de Boer, Wïlfred K de Roos, Sabine C Linn, Alexander L T Imholz, Vivianne C G Tjan-Heijnen, Dutch Breast Cancer Research Group (BOOG). less
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Eleftherios P Mamounas.
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Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update.
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J Clin Oncol, 2020 Jan 14; 38(12). PMID: 31928404
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Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen.
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Ovarian Suppression in Adjuvant Endocrine Therapy for Premenopausal Breast Cancer.
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J Clin Oncol, 2019 Feb 12; 37(11). PMID: 30742565
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Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristics.
Matthew J Ellis, Yu Tao, +9 authors, Jingqin Luo, Roger A'Hern, Dean B Evans, Ajay S Bhatnagar, Hilary A Chaudri Ross, Alexander von Kameke, William R Miller, Ian Smith, Wolfgang Eiermann, Mitch Dowsett. less
J Natl Cancer Inst, 2008 Sep 25; 100(19). PMID: 18812550 Free PMC article.
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The effect of rs5758550 on CYP2D6*2 phenotype and formation of endoxifen in breast cancer patients using tamoxifen.
Anabel B Sanchez-Spitman, Dirk-Jan Ar Moes, +3 authors, Hans Gelderblom, Vincent O Dezentjé, Jesse J Swen, Henk-Jan Guchelaar. less
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Breast cancer index identifies early-stage estrogen receptor-positive breast cancer patients at risk for early- and late-distant recurrence.
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Aromatase inhibitors alone or sequentially combined with tamoxifen in postmenopausal early breast cancer compared with tamoxifen or placebo - Meta-analyses on efficacy and adverse events based on randomized clinical trials.
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Longer-term outcomes of letrozole versus placebo after 5 years of tamoxifen in the NCIC CTG MA.17 trial: analyses adjusting for treatment crossover.
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Which threshold for ER positivity? a retrospective study based on 9639 patients.
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Long term adjuvant endocrine therapy and risk of cardiovascular disease in female breast cancer survivors: systematic review.
Anthony Matthews, Susannah Stanway, +5 authors, Ruth E Farmer, Helen Strongman, Sara Thomas, Alexander R Lyon, Liam Smeeth, Krishnan Bhaskaran. less
BMJ, 2018 Oct 10; 363. PMID: 30297439 Free PMC article.
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Use of letrozole after aromatase inhibitor-based therapy in postmenopausal breast cancer (NRG Oncology/NSABP B-42): a randomised, double-blind, placebo-controlled, phase 3 trial.
Eleftherios P Mamounas, Hanna Bandos, +17 authors, Barry C Lembersky, Jong-Hyeon Jeong, Charles E Geyer, Priya Rastogi, Louis Fehrenbacher, Mark L Graham, Stephen K Chia, Adam M Brufsky, Janice M Walshe, Gamini S Soori, Shaker R Dakhil, Thomas E Seay, James L Wade, Edward C McCarron, Soonmyung Paik, Sandra M Swain, D Lawrence Wickerham, Norman Wolmark. less
Lancet Oncol, 2018 Dec 05; 20(1). PMID: 30509771 Free PMC article.
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Adjuvant exemestane with ovarian suppression in premenopausal breast cancer.
Olivia Pagani, Meredith M Regan, +32 authors, Barbara A Walley, Gini F Fleming, Marco Colleoni, István Láng, Henry L Gomez, Carlo Tondini, Harold J Burstein, Edith A Perez, Eva Ciruelos, Vered Stearns, Hervé R Bonnefoi, Silvana Martino, Charles E Geyer, Graziella Pinotti, Fabio Puglisi, Diana Crivellari, Thomas Ruhstaller, Eric P Winer, Manuela Rabaglio-Poretti, Rudolf Maibach, Barbara Ruepp, Anita Giobbie-Hurder, Karen N Price, Jürg Bernhard, Weixiu Luo, Karin Ribi, Giuseppe Viale, Alan S Coates, Richard D Gelber, Aron Goldhirsch, Prudence A Francis, TEXT and SOFT Investigators, International Breast Cancer Study Group. less
N Engl J Med, 2014 Jun 03; 371(2). PMID: 24881463 Free PMC article.
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Chemotherapy (CT) and hormonotherapy (HT) as neoadjuvant treatment in luminal breast cancer patients: results from the GEICAM/2006-03, a multicenter, randomized, phase-II study.
E Alba, L Calvo, +10 authors, J Albanell, J R De la Haba, A Arcusa Lanza, J I Chacon, P Sanchez-Rovira, A Plazaola, J A Lopez Garcia-Asenjo, B Bermejo, E Carrasco, A Lluch, GEICAM. less
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Exemestane versus anastrozole in postmenopausal women with early breast cancer: NCIC CTG MA.27--a randomized controlled phase III trial.
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J Clin Oncol, 2013 Jan 30; 31(11). PMID: 23358971 Free PMC article.
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Extended duration of adjuvant aromatase inhibitor in breast cancer: a meta-analysis of randomized controlled trials.
Zackariah Clement, James Kollias, +2 authors, Janne Bingham, Robert Whitfield, Melissa Bochner. less
Gland Surg, 2018 Dec 07; 7(5). PMID: 30505766 Free PMC article.
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Impact of premenopausal status at breast cancer diagnosis in women entered on the placebo-controlled NCIC CTG MA17 trial of extended adjuvant letrozole.
P E Goss, J N Ingle, +11 authors, S Martino, N J Robert, H B Muss, R B Livingston, N E Davidson, E A Perez, Y Chavarri-Guerra, D A Cameron, K I Pritchard, T Whelan, L E Shepherd, D Tu. less
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Endocrine Therapy for Early Breast Cancer: Updated Review.
Alexander Tremont, Jonathan Lu, John T Cole.
Ochsner J, 2017 Dec 13; 17(4). PMID: 29230126 Free PMC article.
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Adjuvant Endocrine Therapy for Women With Hormone Receptor-Positive Breast Cancer: ASCO Clinical Practice Guideline Focused Update.
Harold J Burstein, Christina Lacchetti, +9 authors, Holly Anderson, Thomas A Buchholz, Nancy E Davidson, Karen A Gelmon, Sharon H Giordano, Clifford A Hudis, Alexander J Solky, Vered Stearns, Eric P Winer, Jennifer J Griggs. less
J Clin Oncol, 2018 Nov 20; 37(5). PMID: 30452337
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Carol E DeSantis, Jiemin Ma, +5 authors, Mia M Gaudet, Lisa A Newman, Kimberly D Miller, Ann Goding Sauer, Ahmedin Jemal, Rebecca L Siegel. less
CA Cancer J Clin, 2019 Oct 03; 69(6). PMID: 31577379
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Tamoxifen Metabolism and Efficacy in Breast Cancer: A Prospective Multicenter Trial.
Patrick Neven, Lynn Jongen, +22 authors, Anneleen Lintermans, Kathleen Van Asten, Chantal Blomme, Diether Lambrechts, An Poppe, Hans Wildiers, Anne-Sophie Dieudonné, Olivier Brouckaert, Jan Decloedt, Patrick Berteloot, Didier Verhoeven, Markus Joerger, Peter Vuylsteke, Wim Wynendaele, Minne Casteels, Sabine Van Huffel, Willem Lybaert, Johan Van Ginderachter, Robert Paridaens, Ignace Vergote, Vincent Olaf Dezentjé, Ben Van Calster, Henk-Jan Guchelaar. less
Clin Cancer Res, 2018 Feb 21; 24(10). PMID: 29459457
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Ribociclib plus letrozole versus chemotherapy for postmenopausal women with hormone receptor-positive, HER2-negative, luminal B breast cancer (CORALLEEN): an open-label, multicentre, randomised, phase 2 trial.
Aleix Prat, Cristina Saura, +27 authors, Tomás Pascual, Cristina Hernando, Montserrat Muñoz, Laia Paré, Blanca González Farré, Pedro L Fernández, Patricia Galván, Núria Chic, Xavier González Farré, Mafalda Oliveira, Miguel Gil-Gil, Miriam Arumi, Neus Ferrer, Alvaro Montaño, Yann Izarzugaza, Antonio Llombart-Cussac, Raquel Bratos, Santiago González Santiago, Eduardo Martínez, Sergio Hoyos, Beatriz Rojas, Juan Antonio Virizuela, Vanesa Ortega, Rafael López, Pamela Céliz, Eva Ciruelos, Patricia Villagrasa, Joaquín Gavilá. less
Lancet Oncol, 2019 Dec 16; 21(1). PMID: 31838010
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Zoledronic acid combined with adjuvant endocrine therapy of tamoxifen versus anastrozol plus ovarian function suppression in premenopausal early breast cancer: final analysis of the Austrian Breast and Colorectal Cancer Study Group Trial 12.
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Ann Oncol, 2014 Nov 19; 26(2). PMID: 25403582
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Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer.
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Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells.
Jeanette A Richards, Trevor A Petrel, Robert W Brueggemeier.
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Breast Cancer Index and prediction of benefit from extended endocrine therapy in breast cancer patients treated in the Adjuvant Tamoxifen-To Offer More? (aTTom) trial.
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20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years.
Hongchao Pan, Richard Gray, +9 authors, Jeremy Braybrooke, Christina Davies, Carolyn Taylor, Paul McGale, Richard Peto, Kathleen I Pritchard, Jonas Bergh, Mitch Dowsett, Daniel F Hayes, EBCTCG. less
N Engl J Med, 2017 Nov 09; 377(19). PMID: 29117498 Free PMC article.
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Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8·1 years median follow-up.
Meredith M Regan, Patrick Neven, +14 authors, Anita Giobbie-Hurder, Aron Goldhirsch, Bent Ejlertsen, Louis Mauriac, John F Forbes, Ian Smith, István Láng, Andrew Wardley, Manuela Rabaglio, Karen N Price, Richard D Gelber, Alan S Coates, Beat Thürlimann, BIG 1-98 Collaborative Group, International Breast Cancer Study Group (IBCSG). less
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A Brodie, G Sabnis, D Jelovac.
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Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline.
Lyndsay N Harris, Nofisat Ismaila, +11 authors, Lisa M McShane, Fabrice Andre, Deborah E Collyar, Ana M Gonzalez-Angulo, Elizabeth H Hammond, Nicole M Kuderer, Minetta C Liu, Robert G Mennel, Catherine Van Poznak, Robert C Bast, Daniel F Hayes, American Society of Clinical Oncology. less
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Prediction of late distant recurrence in patients with oestrogen-receptor-positive breast cancer: a prospective comparison of the breast-cancer index (BCI) assay, 21-gene recurrence score, and IHC4 in the TransATAC study population.
Dennis C Sgroi, Ivana Sestak, +9 authors, Jack Cuzick, Yi Zhang, Catherine A Schnabel, Brock Schroeder, Mark G Erlander, Anita Dunbier, Kally Sidhu, Elena Lopez-Knowles, Paul E Goss, Mitch Dowsett. less
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Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial.
Christina Davies, Hongchao Pan, +36 authors, Jon Godwin, Richard Gray, Rodrigo Arriagada, Vinod Raina, Mirta Abraham, Victor Hugo Medeiros Alencar, Atef Badran, Xavier Bonfill, Joan Bradbury, Michael Clarke, Rory Collins, Susan R Davis, Antonella Delmestri, John F Forbes, Peiman Haddad, Ming-Feng Hou, Moshe Inbar, Hussein Khaled, Joanna Kielanowska, Wing-Hong Kwan, Beela S Mathew, Indraneel Mittra, Bettina Müller, Antonio Nicolucci, Octavio Peralta, Fany Pernas, Lubos Petruzelka, Tadeusz Pienkowski, Ramachandran Radhika, Balakrishnan Rajan, Maryna T Rubach, Sera Tort, Gerard Urrútia, Miriam Valentini, Yaochen Wang, Richard Peto, Adjuvant Tamoxifen: Longer Against Shorter (ATLAS) Collaborative Group. less
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Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancer.
Rachel C Jankowitz, Kristine Cooper, +5 authors, Mark G Erlander, Xiao-Jun Ma, Nicole C Kesty, Hongying Li, Mamatha Chivukula, Adam Brufsky. less
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Effect of concomitant CYP2D6 inhibitor use and tamoxifen adherence on breast cancer recurrence in early-stage breast cancer.
Vincent O Dezentjé, Nico J C van Blijderveen, +6 authors, Hans Gelderblom, Hein Putter, Myrthe P P van Herk-Sukel, Mariel K Casparie, Antoine C G Egberts, Johan W R Nortier, Henk-Jan Guchelaar. less
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Gonadotropin-Releasing Hormone Agonists for Ovarian Function Preservation in Premenopausal Women Undergoing Chemotherapy for Early-Stage Breast Cancer: A Systematic Review and Meta-analysis.
Rodrigo R Munhoz, Allan A L Pereira, +4 authors, André D Sasse, Paulo M Hoff, Tiffany A Traina, Clifford A Hudis, Ricardo J Marques. less
JAMA Oncol, 2015 Oct 02; 2(1). PMID: 26426573 Free PMC article.
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Preoperative treatment of postmenopausal breast cancer patients with letrozole: A randomized double-blind multicenter study.
W Eiermann, S Paepke, +10 authors, J Appfelstaedt, A Llombart-Cussac, J Eremin, J Vinholes, L Mauriac, M Ellis, M Lassus, H A Chaudri-Ross, M Dugan, M Borgs, Letrozole Neo-Adjuvant Breast Cancer Study Group. less
Ann Oncol, 2002 Feb 02; 12(11). PMID: 11822750
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Pharmacogenomics and Endocrine Therapy in Breast Cancer.
Daniel F Hayes, James M Rae.
J Clin Oncol, 2019 Dec 28; 38(6). PMID: 31880969
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Interpreting quality-of-life data from the SOFT and TEXT trials.
Rowan T Chlebowski.
Lancet Oncol, 2015 Jun 21; 16(7). PMID: 26092819
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Potent Cell-Cycle Inhibition and Upregulation of Immune Response with Abemaciclib and Anastrozole in neoMONARCH, Phase II Neoadjuvant Study in HR+/HER2- Breast Cancer.
Sara A Hurvitz, Miguel Martin, +16 authors, Michael F Press, David Chan, María Fernandez-Abad, Edgar Petru, Regan Rostorfer, Valentina Guarneri, Chiun-Sheng Huang, Susana Barriga, Sameera Wijayawardana, Manisha Brahmachary, Philip J Ebert, Anwar Hossain, Jiangang Liu, Adam Abel, Amit Aggarwal, Valerie M Jansen, Dennis J Slamon. less
Clin Cancer Res, 2019 Oct 17; 26(3). PMID: 31615937 Free PMC article.
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A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer.
Breast International Group (BIG) 1-98 Collaborative Group, Beat Thürlimann, +13 authors, Aparna Keshaviah, Alan S Coates, Henning Mouridsen, Louis Mauriac, John F Forbes, Robert Paridaens, Monica Castiglione-Gertsch, Richard D Gelber, Manuela Rabaglio, Ian Smith, Andrew Wardley, Andrew Wardly, Karen N Price, Aron Goldhirsch. less
N Engl J Med, 2005 Dec 31; 353(26). PMID: 16382061
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A Novel Breast Cancer Index for Prediction of Distant Recurrence in HR+ Early-Stage Breast Cancer with One to Three Positive Nodes.
Yi Zhang, Brock E Schroeder, +4 authors, Piiha-Lotta Jerevall, Amy Ly, Hannah Nolan, Catherine A Schnabel, Dennis C Sgroi. less
Clin Cancer Res, 2017 Sep 25; 23(23). PMID: 28939745
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Efficacy of extended adjuvant therapy with aromatase inhibitors in early breast cancer among common clinicopathologically-defined subgroups: A systematic review and meta-analysis.
Hadar Goldvaser, Ibrahim AlGorashi, +4 authors, Domen Ribnikar, Bostjan Seruga, Arnoud J Templeton, Alberto Ocana, Eitan Amir. less
Cancer Treat Rev, 2017 Sep 08; 60. PMID: 28881223
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Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17.
Paul E Goss, James N Ingle, +15 authors, Silvana Martino, Nicholas J Robert, Hyman B Muss, Martine J Piccart, Monica Castiglione, Dongsheng Tu, Lois E Shepherd, Kathleen I Pritchard, Robert B Livingston, Nancy E Davidson, Larry Norton, Edith A Perez, Jeffrey S Abrams, David A Cameron, Michael J Palmer, Joseph L Pater. less
J Natl Cancer Inst, 2005 Sep 08; 97(17). PMID: 16145047
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Gonadotropin-Releasing Hormone Agonists During Chemotherapy for Preservation of Ovarian Function and Fertility in Premenopausal Patients With Early Breast Cancer: A Systematic Review and Meta-Analysis of Individual Patient-Level Data.
Matteo Lambertini, Halle C F Moore, +18 authors, Robert C F Leonard, Sibylle Loibl, Pamela Munster, Marco Bruzzone, Luca Boni, Joseph M Unger, Richard A Anderson, Keyur Mehta, Susan Minton, Francesca Poggio, Kathy S Albain, Douglas J A Adamson, Bernd Gerber, Amy Cripps, Gianfilippo Bertelli, Sabine Seiler, Marcello Ceppi, Ann H Partridge, Lucia Del Mastro. less
J Clin Oncol, 2018 May 03; 36(19). PMID: 29718793 Free PMC article.
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Invasive Breast Cancer Version 1.2016, NCCN Clinical Practice Guidelines in Oncology.
William J Gradishar, Benjamin O Anderson, +28 authors, Ron Balassanian, Sarah L Blair, Harold J Burstein, Amy Cyr, Anthony D Elias, William B Farrar, Andres Forero, Sharon Hermes Giordano, Matthew Goetz, Lori J Goldstein, Clifford A Hudis, Steven J Isakoff, P Kelly Marcom, Ingrid A Mayer, Beryl McCormick, Meena Moran, Sameer A Patel, Lori J Pierce, Elizabeth C Reed, Kilian E Salerno, Lee S Schwartzberg, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda Telli, John H Ward, Dorothy A Shead, Rashmi Kumar. less
J Natl Compr Canc Netw, 2016 Mar 10; 14(3). PMID: 26957618
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Surgery versus primary endocrine therapy for operable primary breast cancer in elderly women (70 years plus).
D Hind, L Wyld, C B Beverley, M W Reed.
Cochrane Database Syst Rev, 2006 Jan 27; (1). PMID: 16437480
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Treatment Adherence and Its Impact on Disease-Free Survival in the Breast International Group 1-98 Trial of Tamoxifen and Letrozole, Alone and in Sequence.
Jacquie H Chirgwin, Anita Giobbie-Hurder, +12 authors, Alan S Coates, Karen N Price, Bent Ejlertsen, Marc Debled, Richard D Gelber, Aron Goldhirsch, Ian Smith, Manuela Rabaglio, John F Forbes, Patrick Neven, István Láng, Marco Colleoni, Beat Thürlimann. less
J Clin Oncol, 2016 May 25; 34(21). PMID: 27217455 Free PMC article.
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Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer.
A Howell, J Cuzick, +8 authors, M Baum, A Buzdar, M Dowsett, J F Forbes, G Hoctin-Boes, J Houghton, G Y Locker, J S Tobias, ATAC Trialists' Group. less
Lancet, 2005 Jan 11; 365(9453). PMID: 15639680
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Concurrent and sequential initiation of ovarian function suppression with chemotherapy in premenopausal women with endocrine-responsive early breast cancer: an exploratory analysis of TEXT and SOFT.
M M Regan, B A Walley, +15 authors, P A Francis, G F Fleming, I Láng, H L Gómez, M Colleoni, C Tondini, G Pinotti, M Salim, S Spazzapan, V Parmar, T Ruhstaller, E A Abdi, R D Gelber, A S Coates, A Goldhirsch, O Pagani. less
Ann Oncol, 2017 Sep 16; 28(9). PMID: 28911092 Free PMC article.
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Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer.
Joseph A Sparano, Robert J Gray, +27 authors, Peter M Ravdin, Della F Makower, Kathleen I Pritchard, Kathy S Albain, Daniel F Hayes, Charles E Geyer, Elizabeth C Dees, Matthew P Goetz, John A Olson, Tracy Lively, Sunil S Badve, Thomas J Saphner, Lynne I Wagner, Timothy J Whelan, Matthew J Ellis, Soonmyung Paik, William C Wood, Maccon M Keane, Henry L Gomez Moreno, Pavan S Reddy, Timothy F Goggins, Ingrid A Mayer, Adam M Brufsky, Deborah L Toppmeyer, Virginia G Kaklamani, Jeffrey L Berenberg, Jeffrey Abrams, George W Sledge. less
N Engl J Med, 2019 Jun 04; 380(25). PMID: 31157962 Free PMC article.
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Efficacy of extended aromatase inhibitors for hormone-receptor-positive breast cancer: A literature-based meta-analysis of randomized trials.
S P Corona, G Roviello, +17 authors, C Strina, M Milani, S Madaro, D Zanoni, G Allevi, S Aguggini, M R Cappelletti, M Francaviglia, C Azzini, A Cocconi, M Sirico, M Bortul, F Zanconati, F Giudici, P Rosellini, F Meani, O Pagani, D Generali. less
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Extended adjuvant therapy with anastrozole among postmenopausal breast cancer patients: results from the randomized Austrian Breast and Colorectal Cancer Study Group Trial 6a.
Raimund Jakesz, Richard Greil, +12 authors, Michael Gnant, Marianne Schmid, Werner Kwasny, Ernst Kubista, Brigitte Mlineritsch, Christoph Tausch, Michael Stierer, Friedrich Hofbauer, Karl Renner, Christian Dadak, Ernst Rücklinger, Hellmut Samonigg, Austrian Breast and Colorectal Cancer Study Group. less
J Natl Cancer Inst, 2007 Dec 13; 99(24). PMID: 18073378
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Defining Risk of Late Recurrence in Early-Stage Estrogen Receptor-Positive Breast Cancer: Clinical Versus Molecular Tools.
Julia Foldi, Tess O'Meara, +3 authors, Michal Marczyk, Tara Sanft, Andrea Silber, Lajos Pusztai. less
J Clin Oncol, 2019 Apr 04; 37(16). PMID: 30943126
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Persistence in patients with breast cancer treated with tamoxifen or aromatase inhibitors: a retrospective database analysis.
P Hadji, V Ziller, +4 authors, J Kyvernitakis, M Bauer, G Haas, N Schmidt, K Kostev. less
Breast Cancer Res Treat, 2013 Jan 22; 138(1). PMID: 23334803
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Toxicity of Extended Adjuvant Therapy With Aromatase Inhibitors in Early Breast Cancer: A Systematic Review and Meta-analysis.
Hadar Goldvaser, Tristan A Barnes, +4 authors, Boštjan Šeruga, David W Cescon, Alberto Ocaña, Domen Ribnikar, Eitan Amir. less
J Natl Cancer Inst, 2017 Sep 20; 110(1). PMID: 28922781
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Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1-98.
Alan S Coates, Aparna Keshaviah, +17 authors, Beat Thürlimann, Henning Mouridsen, Louis Mauriac, John F Forbes, Robert Paridaens, Monica Castiglione-Gertsch, Richard D Gelber, Marco Colleoni, István Láng, Lucia Del Mastro, Ian Smith, Jacquie Chirgwin, Jean-Marie Nogaret, Tadeusz Pienkowski, Andrew Wardley, Erik H Jakobsen, Karen N Price, Aron Goldhirsch. less
J Clin Oncol, 2007 Jan 04; 25(5). PMID: 17200148
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Aromatase expression in the human breast.
A Brodie, B Long, Q Lu.
Breast Cancer Res Treat, 1998 Oct 31; 49 Suppl 1. PMID: 9797022
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Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment.
Silvana Borges, Zeruesenay Desta, +11 authors, Lang Li, Todd C Skaar, Bryan A Ward, Anne Nguyen, Yan Jin, Anna Maria Storniolo, D Michele Nikoloff, Lin Wu, Grant Hillman, Daniel F Hayes, Vered Stearns, David A Flockhart. less
Clin Pharmacol Ther, 2006 Jul 04; 80(1). PMID: 16815318
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Prediction of late disease recurrence and extended adjuvant letrozole benefit by the HOXB13/IL17BR biomarker.
Dennis C Sgroi, Erin Carney, +16 authors, Elizabeth Zarrella, Lauren Steffel, Shemeica N Binns, Dianne M Finkelstein, Jackie Szymonifka, Atul K Bhan, Lois E Shepherd, Yi Zhang, Catherine A Schnabel, Mark G Erlander, James N Ingle, Peggy Porter, Hyman B Muss, Katherine I Pritchard, Dongsheng Tu, David L Rimm, Paul E Goss. less
J Natl Cancer Inst, 2013 Jul 03; 105(14). PMID: 23812955 Free PMC article.
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Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG), C Davies, +11 authors, J Godwin, R Gray, M Clarke, D Cutter, S Darby, P McGale, H C Pan, C Taylor, Y C Wang, M Dowsett, J Ingle, R Peto. less
Lancet, 2011 Aug 02; 378(9793). PMID: 21802721 Free PMC article.
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A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer.
Xiao-Jun Ma, Ranelle Salunga, +8 authors, Sonika Dahiya, Wilson Wang, Erin Carney, Virginie Durbecq, Adrian Harris, Paul Goss, Christos Sotiriou, Mark Erlander, Dennis Sgroi. less
Clin Cancer Res, 2008 May 03; 14(9). PMID: 18451222
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Extended adjuvant intermittent letrozole versus continuous letrozole in postmenopausal women with breast cancer (SOLE): a multicentre, open-label, randomised, phase 3 trial.
Marco Colleoni, Weixiu Luo, +30 authors, Per Karlsson, Jacquie Chirgwin, Stefan Aebi, Guy Jerusalem, Patrick Neven, Erika Hitre, Marie-Pascale Graas, Edda Simoncini, Claus Kamby, Alastair Thompson, Sibylle Loibl, Joaquín Gavilá, Katsumasa Kuroi, Christian Marth, Bettina Müller, Seamus O'Reilly, Vincenzo Di Lauro, Andrea Gombos, Thomas Ruhstaller, Harold Burstein, Karin Ribi, Jürg Bernhard, Giuseppe Viale, Rudolf Maibach, Manuela Rabaglio-Poretti, Richard D Gelber, Alan S Coates, Angelo Di Leo, Meredith M Regan, Aron Goldhirsch, SOLE Investigators. less
Lancet Oncol, 2017 Nov 22; 19(1). PMID: 29158011
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Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer.
Prudence A Francis, Olivia Pagani, +34 authors, Gini F Fleming, Barbara A Walley, Marco Colleoni, István Láng, Henry L Gómez, Carlo Tondini, Eva Ciruelos, Harold J Burstein, Hervé R Bonnefoi, Meritxell Bellet, Silvana Martino, Charles E Geyer, Matthew P Goetz, Vered Stearns, Graziella Pinotti, Fabio Puglisi, Simon Spazzapan, Miguel A Climent, Lorenzo Pavesi, Thomas Ruhstaller, Nancy E Davidson, Robert Coleman, Marc Debled, Stefan Buchholz, James N Ingle, Eric P Winer, Rudolf Maibach, Manuela Rabaglio-Poretti, Barbara Ruepp, Angelo Di Leo, Alan S Coates, Richard D Gelber, Aron Goldhirsch, Meredith M Regan, SOFT and TEXT Investigators and the International Breast Cancer Study Group. less
N Engl J Med, 2018 Jun 05; 379(2). PMID: 29863451 Free PMC article.
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CDK4/6 inhibition in breast cancer: current practice and future directions.
Sonia Pernas, Sara M Tolaney, Eric P Winer, Shom Goel.
Ther Adv Med Oncol, 2018 Jul 25; 10. PMID: 30038670 Free PMC article.
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Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial.
Jack Cuzick, Ivana Sestak, +5 authors, Michael Baum, Aman Buzdar, Anthony Howell, Mitch Dowsett, John F Forbes, ATAC/LATTE investigators. less
Lancet Oncol, 2010 Nov 23; 11(12). PMID: 21087898
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Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort.
N Lynn Henry, James M Rae, +11 authors, Lang Li, Faouzi Azzouz, Todd C Skaar, Zereunesay Desta, Matthew J Sikora, Santosh Philips, Anne T Nguyen, Anna Maria Storniolo, Daniel F Hayes, David A Flockhart, Vered Stearns, Consortium on Breast Cancer Pharmacogenomics Investigators. less
Breast Cancer Res Treat, 2009 Jan 21; 117(3). PMID: 19153830 Free PMC article.
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.
Matthew P Goetz, Katrin Sangkuhl, +12 authors, Henk-Jan Guchelaar, Matthias Schwab, Michael Province, Michelle Whirl-Carrillo, W Fraser Symmans, Howard L McLeod, Mark J Ratain, Hitoshi Zembutsu, Andrea Gaedigk, Ron H van Schaik, James N Ingle, Kelly E Caudle, Teri E Klein. less
Clin Pharmacol Ther, 2018 Feb 01; 103(5). PMID: 29385237 Free PMC article.
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