Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells. Chi Ma, Miaojun Han, +20 authors, Bernd Heinrich, Qiong Fu, Qianfei Zhang, Milan Sandhu, David Agdashian, Masaki Terabe, Jay A Berzofsky, Valerie Fako, Thomas Ritz, Thomas Longerich, Casey M Theriot, John A McCulloch, Soumen Roy, Wuxing Yuan, Vishal Thovarai, Shurjo K Sen, Mathuros Ruchirawat, Firouzeh Korangy, Xin Wei Wang, Giorgio Trinchieri, Tim F Greten. less Science, 2018 May 26; 360(6391). PMID: 29798856 Free PMC article. Highly Cited.
|
Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics. Hamad Alshetaiwi, Nicholas Pervolarakis, +10 authors, Laura Lynn McIntyre, Dennis Ma, Quy Nguyen, Jan Akara Rath, Kevin Nee, Grace Hernandez, Katrina Evans, Leona Torosian, Anushka Silva, Craig Walsh, Kai Kessenbrock. less Sci Immunol, 2020 Feb 23; 5(44). PMID: 32086381 Free PMC article.
|
Organ-specific response to nivolumab in patients with non-small cell lung cancer (NSCLC). Sabine Schmid, Stefan Diem, +7 authors, Qiyu Li, Mirjam Krapf, Lukas Flatz, Sebastian Leschka, Lotus Desbiolles, Dirk Klingbiel, Wolfram Jochum, Martin Früh. less Cancer Immunol Immunother, 2018 Sep 02; 67(12). PMID: 30171269
|
Baseline Tumor Size Is an Independent Prognostic Factor for Overall Survival in Patients with Melanoma Treated with Pembrolizumab. Richard W Joseph, Jeroen Elassaiss-Schaap, +19 authors, Richard Kefford, Wen-Jen Hwu, Jedd D Wolchok, Anthony M Joshua, Antoni Ribas, F Stephen Hodi, Omid Hamid, Caroline Robert, Adil Daud, Roxana Dronca, Peter Hersey, Jeffrey S Weber, Amita Patnaik, Dinesh P de Alwis, Andrea Perrone, Jin Zhang, S Peter Kang, Scot Ebbinghaus, Keaven M Anderson, Tara C Gangadhar. less Clin Cancer Res, 2018 Apr 25; 24(20). PMID: 29685882 Free PMC article. Highly Cited.
|
Antigen-presenting cell function in the tolerogenic liver environment. Angus W Thomson, Percy A Knolle. Nat Rev Immunol, 2010 Oct 26; 10(11). PMID: 20972472 Highly Cited. Review.
|
Predictive factors for hyperprogressive disease during nivolumab as anti-PD1 treatment in patients with advanced gastric cancer. Akinori Sasaki, Yoshiaki Nakamura, +10 authors, Saori Mishima, Akihito Kawazoe, Yasutoshi Kuboki, Hideaki Bando, Takashi Kojima, Toshihiko Doi, Atsushi Ohtsu, Takayuki Yoshino, Takeshi Kuwata, Tetsuo Akimoto, Kohei Shitara. less Gastric Cancer, 2019 Jan 11; 22(4). PMID: 30627987 Highly Cited.
|
Integrating single-cell transcriptomic data across different conditions, technologies, and species. Andrew Butler, Paul Hoffman, +2 authors, Peter Smibert, Efthymia Papalexi, Rahul Satija. less Nat Biotechnol, 2018 Apr 03; 36(5). PMID: 29608179 Free PMC article. Highly Cited.
|
Presentation of hepatocellular antigens. Arash Grakoui, Ian Nicholas Crispe. Cell Mol Immunol, 2016 Mar 01; 13(3). PMID: 26924525 Free PMC article. Review.
|
DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25. Linbin Yang, Qiang Liu, +12 authors, Xiaoqian Zhang, Xinwei Liu, Boxuan Zhou, Jianing Chen, Di Huang, Jiaqian Li, Heliang Li, Fei Chen, Jiang Liu, Yue Xing, Xueman Chen, Shicheng Su, Erwei Song. less Nature, 2020 Jun 13; 583(7814). PMID: 32528174
|
Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner. Rikke B Holmgaard, Dmitriy Zamarin, +5 authors, Yanyun Li, Billel Gasmi, David H Munn, James P Allison, Taha Merghoub, Jedd D Wolchok. less Cell Rep, 2015 Sep 29; 13(2). PMID: 26411680 Free PMC article. Highly Cited.
|
Cross-talk between tumors at anatomically distinct sites. Amanda J Oliver, Phillip K Darcy, +2 authors, Joseph A Trapani, Michael H Kershaw, Clare Y Slaney. less FEBS J, 2020 Apr 06; 288(1). PMID: 32248616 Review.
|
CD83 expression in CD4+ T cells modulates inflammation and autoimmunity. Simone Reinwald, Carsten Wiethe, +6 authors, Astrid M Westendorf, Minka Breloer, Michael Probst-Kepper, Bernhard Fleischer, Alexander Steinkasserer, Jan Buer, Wiebke Hansen. less J Immunol, 2008 Apr 22; 180(9). PMID: 18424708
|
A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. Kevin C Barry, Joy Hsu, +19 authors, Miranda L Broz, Francisco J Cueto, Mikhail Binnewies, Alexis J Combes, Amanda E Nelson, Kimberly Loo, Raj Kumar, Michael D Rosenblum, Michael D Alvarado, Denise M Wolf, Dusan Bogunovic, Nina Bhardwaj, Adil I Daud, Patrick K Ha, William R Ryan, Joshua L Pollack, Bushra Samad, Saurabh Asthana, Vincent Chan, Matthew F Krummel. less Nat Med, 2018 Jun 27; 24(8). PMID: 29942093 Free PMC article. Highly Cited.
|
The landscape of metastatic progression patterns across major human cancers. Jan Budczies, Moritz von Winterfeld, +10 authors, Frederick Klauschen, Michael Bockmayr, Jochen K Lennerz, Carsten Denkert, Thomas Wolf, Arne Warth, Manfred Dietel, Ioannis Anagnostopoulos, Wilko Weichert, Daniel Wittschieber, Albrecht Stenzinger. less Oncotarget, 2014 Nov 18; 6(1). PMID: 25402435 Free PMC article.
|
CD83 expression is essential for Treg cell differentiation and stability. Marina Doebbeler, Christina Koenig, +20 authors, Lena Krzyzak, Christine Seitz, Andreas Wild, Thomas Ulas, Kevin Baßler, Dmitry Kopelyanskiy, Alina Butterhof, Christine Kuhnt, Simon Kreiser, Lena Stich, Elisabeth Zinser, Ilka Knippertz, Stefan Wirtz, Christin Riegel, Petra Hoffmann, Matthias Edinger, Lars Nitschke, Thomas Winkler, Joachim L Schultze, Alexander Steinkasserer, Matthias Lechmann. less JCI Insight, 2018 Jun 08; 3(11). PMID: 29875316 Free PMC article.
|
Immunity, tolerance and autoimmunity in the liver: A comprehensive review. Derek G Doherty. J Autoimmun, 2015 Sep 12; 66. PMID: 26358406 Highly Cited. Review.
|
Higher frequencies of GARP(+)CTLA-4(+)Foxp3(+) T regulatory cells and myeloid-derived suppressor cells in hepatocellular carcinoma patients are associated with impaired T-cell functionality. Suresh Kalathil, Amit A Lugade, +2 authors, Austin Miller, Renuka Iyer, Yasmin Thanavala. less Cancer Res, 2013 Feb 21; 73(8). PMID: 23423978 Free PMC article. Highly Cited.
|
Treg cell-based therapies: challenges and perspectives. Caroline Raffin, Linda T Vo, Jeffrey A Bluestone. Nat Rev Immunol, 2019 Dec 08; 20(3). PMID: 31811270 Free PMC article. Review.
|
Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment. Rinat Zaynagetdinov, Taylor P Sherrill, +10 authors, Linda A Gleaves, Allyson G McLoed, Jamie A Saxon, Arun C Habermann, Linda Connelly, Daniel Dulek, R Stokes Peebles, Barbara Fingleton, Fiona E Yull, Georgios T Stathopoulos, Timothy S Blackwell. less Cancer Res, 2015 Feb 19; 75(8). PMID: 25691457 Free PMC article.
|
Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Mark J Selby, John J Engelhardt, +4 authors, Michael Quigley, Karla A Henning, Timothy Chen, Mohan Srinivasan, Alan J Korman. less Cancer Immunol Res, 2014 Apr 30; 1(1). PMID: 24777248 Highly Cited.
|
Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines. Channakeshava Sokke Umeshappa, Santiswarup Singha, +7 authors, Jesus Blanco, Kun Shao, Roopa Hebbandi Nanjundappa, Jun Yamanouchi, Albert Parés, Pau Serra, Yang Yang, Pere Santamaria. less Nat Commun, 2019 May 16; 10(1). PMID: 31089130 Free PMC article.
|
High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy. Matthew M Gubin, Ekaterina Esaulova, +16 authors, Jeffrey P Ward, Olga N Malkova, Daniele Runci, Pamela Wong, Takuro Noguchi, Cora D Arthur, Wei Meng, Elise Alspach, Ruan F V Medrano, Catrina Fronick, Michael Fehlings, Evan W Newell, Robert S Fulton, Kathleen C F Sheehan, Stephen T Oh, Robert D Schreiber, Maxim N Artyomov. less Cell, 2018 Oct 23; 175(4). PMID: 30343900 Free PMC article. Highly Cited.
|
CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis. Alice McNally, Geoffrey R Hill, +2 authors, Tim Sparwasser, Ranjeny Thomas, Raymond J Steptoe. less Proc Natl Acad Sci U S A, 2011 Apr 20; 108(18). PMID: 21502514 Free PMC article.
|
Regulatory T cells in cancer immunotherapy. Atsushi Tanaka, Shimon Sakaguchi. Cell Res, 2016 Dec 21; 27(1). PMID: 27995907 Free PMC article. Highly Cited. Review.
|
Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells. Marc Vocanson, Aurore Rozieres, +8 authors, Anca Hennino, Gaelle Poyet, Vincent Gaillard, Sarah Renaudineau, Amine Achachi, Josette Benetiere, Dominique Kaiserlian, Bertrand Dubois, Jean-François Nicolas. less J Allergy Clin Immunol, 2010 Jul 14; 126(2). PMID: 20624644
|
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade. Spencer C Wei, Jacob H Levine, +8 authors, Alexandria P Cogdill, Yang Zhao, Nana-Ama A S Anang, Miles C Andrews, Padmanee Sharma, Jing Wang, Jennifer A Wargo, Dana Pe'er, James P Allison. less Cell, 2017 Aug 15; 170(6). PMID: 28803728 Free PMC article. Highly Cited.
|
Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Christopher E Rudd, Helga Schneider. Nat Rev Immunol, 2003 Jul 24; 3(7). PMID: 12876557
|
Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells. Billur Akkaya, Yoshihiro Oya, +8 authors, Munir Akkaya, Jafar Al Souz, Amanda H Holstein, Olena Kamenyeva, Juraj Kabat, Ryutaro Matsumura, David W Dorward, Deborah D Glass, Ethan M Shevach. less Nat Immunol, 2019 Jan 16; 20(2). PMID: 30643268 Free PMC article. Highly Cited.
|
Site-specific response patterns, pseudoprogression, and acquired resistance in patients with melanoma treated with ipilimumab combined with anti-PD-1 therapy. Ines Pires da Silva, Serigne Lo, +4 authors, Camelia Quek, Maria Gonzalez, Matteo S Carlino, Georgina V Long, Alexander M Menzies. less Cancer, 2019 Oct 05; 126(1). PMID: 31584722
|
Immune tolerance in liver disease. Ian N Crispe. Hepatology, 2014 Jun 11; 60(6). PMID: 24913836 Free PMC article. Highly Cited.
|
Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy. Xiaozhou Fan, Sergio A Quezada, +2 authors, Manuel A Sepulveda, Padmanee Sharma, James P Allison. less J Exp Med, 2014 Apr 02; 211(4). PMID: 24687957 Free PMC article. Highly Cited.
|
Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity. Kelsey E Sivick, Anthony L Desbien, +22 authors, Laura Hix Glickman, Gabrielle L Reiner, Leticia Corrales, Natalie H Surh, Thomas E Hudson, Uyen T Vu, Brian J Francica, Tamara Banda, George E Katibah, David B Kanne, Justin J Leong, Ken Metchette, Jacob R Bruml, Chudi O Ndubaku, Jeffrey M McKenna, Yan Feng, Lianxing Zheng, Steven L Bender, Charles Y Cho, Meredith L Leong, Andrea van Elsas, Thomas W Dubensky, Sarah M McWhirter. less Cell Rep, 2018 Dec 13; 25(11). PMID: 30540940 Highly Cited.
|
Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy. Jonathan M Weiss, Lisa A Ridnour, +8 authors, Tim Back, S Perwez Hussain, Peijun He, Anna E Maciag, Larry K Keefer, William J Murphy, Curtis C Harris, David A Wink, Robert H Wiltrout. less J Exp Med, 2010 Oct 06; 207(11). PMID: 20921282 Free PMC article.
|
Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Christoph Hafemeister, Rahul Satija. Genome Biol, 2019 Dec 25; 20(1). PMID: 31870423 Free PMC article. Highly Cited.
|
Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC. Paul C Tumeh, Matthew D Hellmann, +31 authors, Omid Hamid, Katy K Tsai, Kimberly L Loo, Matthew A Gubens, Michael Rosenblum, Christina L Harview, Janis M Taube, Nathan Handley, Neharika Khurana, Adi Nosrati, Matthew F Krummel, Andrew Tucker, Eduardo V Sosa, Phillip J Sanchez, Nooriel Banayan, Juan C Osorio, Dan L Nguyen-Kim, Jeremy Chang, I Peter Shintaku, Peter D Boasberg, Emma J Taylor, Pamela N Munster, Alain P Algazi, Bartosz Chmielowski, Reinhard Dummer, Tristan R Grogan, David Elashoff, Jimmy Hwang, Simone M Goldinger, Edward B Garon, Robert H Pierce, Adil Daud. less Cancer Immunol Res, 2017 Apr 16; 5(5). PMID: 28411193 Free PMC article. Highly Cited.
|
Hepatic T cells and liver tolerance. Ian Nicholas Crispe. Nat Rev Immunol, 2003 Jan 04; 3(1). PMID: 12511875 Highly Cited. Review.
|
Targets for immunotherapy of liver cancer. Tim F Greten, Bruno Sangro. J Hepatol, 2017 Sep 20;. PMID: 28923358 Free PMC article. Review.
|
GILZ promotes production of peripherally induced Treg cells and mediates the crosstalk between glucocorticoids and TGF-β signaling. Oxana Bereshchenko, Maddalena Coppo, +7 authors, Stefano Bruscoli, Michele Biagioli, Monica Cimino, Tiziana Frammartino, Daniele Sorcini, Alessandra Venanzi, Moises Di Sante, Carlo Riccardi. less Cell Rep, 2014 Apr 08; 7(2). PMID: 24703841
|
Liver-Mediated Adaptive Immune Tolerance. Meijuan Zheng, Zhigang Tian. Front Immunol, 2019 Dec 04; 10. PMID: 31787967 Free PMC article. Review.
|
Hepatocytes as Immunological Agents. Ian N Crispe. J Immunol, 2015 Dec 20; 196(1). PMID: 26685314 Free PMC article. Review.
|
Non-conventional Inhibitory CD4+Foxp3-PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity. Roberta Zappasodi, Sadna Budhu, +13 authors, Matthew D Hellmann, Michael A Postow, Yasin Senbabaoglu, Sasikanth Manne, Billel Gasmi, Cailian Liu, Hong Zhong, Yanyun Li, Alexander C Huang, Daniel Hirschhorn-Cymerman, Katherine S Panageas, E John Wherry, Taha Merghoub, Jedd D Wolchok. less Cancer Cell, 2018 Oct 10; 34(4). PMID: 30300585 Free PMC article.
|
Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy. Kimberly Loo, Katy K Tsai, +14 authors, Kelly Mahuron, Jacqueline Liu, Mariela L Pauli, Priscila M Sandoval, Adi Nosrati, James Lee, Lawrence Chen, Jimmy Hwang, Lauren S Levine, Matthew F Krummel, Alain P Algazi, Miguel Pampaloni, Michael D Alvarado, Michael D Rosenblum, Adil I Daud. less JCI Insight, 2017 Jul 21; 2(14). PMID: 28724802 Free PMC article.
|
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Jeong M Kim, Jeffrey P Rasmussen, Alexander Y Rudensky. Nat Immunol, 2006 Dec 01; 8(2). PMID: 17136045 Highly Cited.
|
Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy. Jan Broder Engler, Nina Kursawe, +8 authors, María Emilia Solano, Kostas Patas, Sabine Wehrmann, Nina Heckmann, Fred Lühder, Holger M Reichardt, Petra Clara Arck, Stefan M Gold, Manuel A Friese. less Proc Natl Acad Sci U S A, 2017 Jan 05; 114(2). PMID: 28049829 Free PMC article.
|
Regulatory T cell development in the absence of functional Foxp3. Wen Lin, Dipica Haribhai, +4 authors, Lance M Relland, Nga Truong, Marc R Carlson, Calvin B Williams, Talal A Chatila. less Nat Immunol, 2007 Feb 03; 8(4). PMID: 17273171 Highly Cited.
|
Establishment of Orthotopic Liver Tumors by Surgical Intrahepatic Tumor Injection in Mice with Underlying Non-Alcoholic Fatty Liver Disease. Zachary J Brown, Bernd Heinrich, Tim F Greten. Methods Protoc, 2019 Jun 06; 1(2). PMID: 31164564 Free PMC article.
|
Is autoimmunity the Achilles' heel of cancer immunotherapy? Carl H June, Jeremy T Warshauer, Jeffrey A Bluestone. Nat Med, 2017 May 06; 23(5). PMID: 28475571 Highly Cited.
|
Sites of metastasis and association with clinical outcome in advanced stage cancer patients treated with immunotherapy. Mehmet Asim Bilen, Julie M Shabto, +17 authors, Dylan J Martini, Yuan Liu, Colleen Lewis, Hannah Collins, Mehmet Akce, Haydn Kissick, Bradley C Carthon, Walid L Shaib, Olatunji B Alese, Conor E Steuer, Christina Wu, David H Lawson, Ragini Kudchadkar, Viraj A Master, Bassel El-Rayes, Suresh S Ramalingam, Taofeek K Owonikoko, R Donald Harvey. less BMC Cancer, 2019 Aug 30; 19(1). PMID: 31464611 Free PMC article.
|
Five-Year Survival and Correlates Among Patients With Advanced Melanoma, Renal Cell Carcinoma, or Non-Small Cell Lung Cancer Treated With Nivolumab. Suzanne L Topalian, F Stephen Hodi, +17 authors, Julie R Brahmer, Scott N Gettinger, David C Smith, David F McDermott, John D Powderly, Jeffrey A Sosman, Michael B Atkins, Philip D Leming, David R Spigel, Scott J Antonia, Alexander Drilon, Jedd D Wolchok, Richard D Carvajal, M Brent McHenry, Fareeda Hosein, Christopher T Harbison, Joseph F Grosso, Mario Sznol. less JAMA Oncol, 2019 Jul 26; 5(10). PMID: 31343665 Free PMC article. Highly Cited.
|
Meta-Analysis Evaluating the Impact of Site of Metastasis on Overall Survival in Men With Castration-Resistant Prostate Cancer. Susan Halabi, William Kevin Kelly, +22 authors, Hua Ma, Haojin Zhou, Nicole C Solomon, Karim Fizazi, Catherine M Tangen, Mark Rosenthal, Daniel P Petrylak, Maha Hussain, Nicholas J Vogelzang, Ian M Thompson, Kim N Chi, Johann de Bono, Andrew J Armstrong, Mario A Eisenberger, Abderrahim Fandi, Shaoyi Li, John C Araujo, Christopher J Logothetis, David I Quinn, Michael J Morris, Celestia S Higano, Ian F Tannock, Eric J Small. less J Clin Oncol, 2016 Mar 10; 34(14). PMID: 26951312 Free PMC article. Highly Cited.
|
Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice. Antonella Carambia, Barbara Freund, +17 authors, Dorothee Schwinge, Oliver T Bruns, Sunhild C Salmen, Harald Ittrich, Rudolph Reimer, Markus Heine, Samuel Huber, Christian Waurisch, Alexander Eychmüller, David C Wraith, Thomas Korn, Peter Nielsen, Horst Weller, Christoph Schramm, Stefan Lüth, Ansgar W Lohse, Joerg Heeren, Johannes Herkel. less J Hepatol, 2015 Jan 27; 62(6). PMID: 25617499
|
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Alexander C Huang, Michael A Postow, +31 authors, Robert J Orlowski, Rosemarie Mick, Bertram Bengsch, Sasikanth Manne, Wei Xu, Shannon Harmon, Josephine R Giles, Brandon Wenz, Matthew Adamow, Deborah Kuk, Katherine S Panageas, Cristina Carrera, Phillip Wong, Felix Quagliarello, Bradley Wubbenhorst, Kurt D'Andrea, Kristen E Pauken, Ramin S Herati, Ryan P Staupe, Jason M Schenkel, Suzanne McGettigan, Shawn Kothari, Sangeeth M George, Robert H Vonderheide, Ravi K Amaravadi, Giorgos C Karakousis, Lynn M Schuchter, Xiaowei Xu, Katherine L Nathanson, Jedd D Wolchok, Tara C Gangadhar, E John Wherry. less Nature, 2017 Apr 12; 545(7652). PMID: 28397821 Free PMC article. Highly Cited.
|
Comprehensive Integration of Single-Cell Data. Tim Stuart, Andrew Butler, +7 authors, Paul Hoffman, Christoph Hafemeister, Efthymia Papalexi, William M Mauck, Yuhan Hao, Marlon Stoeckius, Peter Smibert, Rahul Satija. less Cell, 2019 Jun 11; 177(7). PMID: 31178118 Free PMC article. Highly Cited.
|
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. Tyler R Simpson, Fubin Li, +11 authors, Welby Montalvo-Ortiz, Manuel A Sepulveda, Katharina Bergerhoff, Frederick Arce, Claire Roddie, Jake Y Henry, Hideo Yagita, Jedd D Wolchok, Karl S Peggs, Jeffrey V Ravetch, James P Allison, Sergio A Quezada. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981 Free PMC article. Highly Cited.
|
Depletion of myeloid-derived suppressor cells during interleukin-12 immunogene therapy does not confer a survival advantage in experimental malignant glioma. B Thaci, A U Ahmed, +8 authors, I V Ulasov, D A Wainwright, P Nigam, B Auffinger, A L Tobias, Y Han, L Zhang, K-S Moon, M S Lesniak. less Cancer Gene Ther, 2014 Jan 18; 21(1). PMID: 24434573 Free PMC article.
|
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer. Takahiro Kamada, Yosuke Togashi, +13 authors, Christopher Tay, Danbee Ha, Akinori Sasaki, Yoshiaki Nakamura, Eiichi Sato, Shota Fukuoka, Yasuko Tada, Atsushi Tanaka, Hiromasa Morikawa, Akihito Kawazoe, Takahiro Kinoshita, Kohei Shitara, Shimon Sakaguchi, Hiroyoshi Nishikawa. less Proc Natl Acad Sci U S A, 2019 Apr 28; 116(20). PMID: 31028147 Free PMC article. Highly Cited.
|
Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. V Bronte, E Apolloni, +5 authors, A Cabrelle, R Ronca, P Serafini, P Zamboni, N P Restifo, P Zanovello. less Blood, 2000 Nov 23; 96(12). PMID: 11090068 Free PMC article. Highly Cited.
|
Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. A J McAdam, T T Chang, +11 authors, A E Lumelsky, E A Greenfield, V A Boussiotis, J S Duke-Cohan, T Chernova, N Malenkovich, C Jabs, V K Kuchroo, V Ling, M Collins, A H Sharpe, G J Freeman. less J Immunol, 2000 Oct 25; 165(9). PMID: 11046032 Highly Cited.
|
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing. Chunhong Zheng, Liangtao Zheng, +13 authors, Jae-Kwang Yoo, Huahu Guo, Yuanyuan Zhang, Xinyi Guo, Boxi Kang, Ruozhen Hu, Julie Y Huang, Qiming Zhang, Zhouzerui Liu, Minghui Dong, Xueda Hu, Wenjun Ouyang, Jirun Peng, Zemin Zhang. less Cell, 2017 Jun 18; 169(7). PMID: 28622514 Highly Cited.
|
Cancer immunotherapy using checkpoint blockade. Antoni Ribas, Jedd D Wolchok. Science, 2018 Mar 24; 359(6382). PMID: 29567705 Free PMC article. Highly Cited. Review.
|
Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells. Alfonso R Sánchez-Paulete, Francisco J Cueto, +9 authors, María Martínez-López, Sara Labiano, Aizea Morales-Kastresana, María E Rodríguez-Ruiz, Maria Jure-Kunkel, Arantza Azpilikueta, M Angela Aznar, José I Quetglas, David Sancho, Ignacio Melero. less Cancer Discov, 2015 Oct 24; 6(1). PMID: 26493961 Free PMC article. Highly Cited.
|
Modulation of EZH2 expression in T cells improves efficacy of anti-CTLA-4 therapy. Sangeeta Goswami, Irina Apostolou, +10 authors, Jan Zhang, Jill Skepner, Swetha Anandhan, Xuejun Zhang, Liangwen Xiong, Patrick Trojer, Ana Aparicio, Sumit K Subudhi, James P Allison, Hao Zhao, Padmanee Sharma. less J Clin Invest, 2018 Jun 16; 128(9). PMID: 29905573 Free PMC article.
|
CTLA-4-mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells. Vitalijs Ovcinnikovs, Ellen M Ross, +9 authors, Lina Petersone, Natalie M Edner, Frank Heuts, Elisavet Ntavli, Alexandros Kogimtzis, Alan Kennedy, Chun Jing Wang, Clare L Bennett, David M Sansom, Lucy S K Walker. less Sci Immunol, 2019 Jun 04; 4(35). PMID: 31152091 Free PMC article.
|
Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma. Adil I Daud, Kimberly Loo, +15 authors, Mariela L Pauli, Robert Sanchez-Rodriguez, Priscila Munoz Sandoval, Keyon Taravati, Katy Tsai, Adi Nosrati, Lorenzo Nardo, Michael D Alvarado, Alain P Algazi, Miguel H Pampaloni, Iryna V Lobach, Jimmy Hwang, Robert H Pierce, Iris K Gratz, Matthew F Krummel, Michael D Rosenblum. less J Clin Invest, 2016 Aug 16; 126(9). PMID: 27525433 Free PMC article. Highly Cited.
|
Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery. Suzanne I S Mosely, John E Prime, +21 authors, Richard C A Sainson, Jens-Oliver Koopmann, Dennis Y Q Wang, Danielle M Greenawalt, Miika J Ahdesmaki, Rebecca Leyland, Stefanie Mullins, Luciano Pacelli, Danielle Marcus, Judith Anderton, Amanda Watkins, Jane Coates Ulrichsen, Philip Brohawn, Brandon W Higgs, Matthew McCourt, Hazel Jones, James A Harper, Michelle Morrow, Viia Valge-Archer, Ross Stewart, Simon J Dovedi, Robert W Wilkinson. less Cancer Immunol Res, 2016 Dec 08; 5(1). PMID: 27923825 Highly Cited.
|
Tumor-infiltrating human CD4+ regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity. Mojgan Ahmadzadeh, Anna Pasetto, +4 authors, Li Jia, Drew C Deniger, Sanja Stevanović, Paul F Robbins, Steven A Rosenberg. less Sci Immunol, 2019 Jan 13; 4(31). PMID: 30635355 Free PMC article. Highly Cited.
|
Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells. Andrea Kristina Horst, Katrin Neumann, Linda Diehl, Gisa Tiegs. Cell Mol Immunol, 2016 Apr 05; 13(3). PMID: 27041638 Free PMC article. Highly Cited. Review.
|
Regulatory T cells, especially ICOS+ FOXP3+ regulatory T cells, are increased in the hepatocellular carcinoma microenvironment and predict reduced survival. Jian-Fei Tu, Ya-Hui Ding, +5 authors, Xi-Hui Ying, Fa-Zong Wu, Xin-Mu Zhou, Deng-Ke Zhang, Hai Zou, Jian-Song Ji. less Sci Rep, 2016 Oct 12; 6. PMID: 27725696 Free PMC article.
|
Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. David Wang, Jason Quiros, +12 authors, Kelly Mahuron, Chien-Chun Pai, Valeria Ranzani, Arabella Young, Stephanie Silveria, Tory Harwin, Arbi Abnousian, Massimiliano Pagani, Michael D Rosenblum, Frederic Van Gool, Lawrence Fong, Jeffrey A Bluestone, Michel DuPage. less Cell Rep, 2018 Jun 14; 23(11). PMID: 29898397 Free PMC article. Highly Cited.
|
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Mei-Ling Chen, Mikaël J Pittet, +4 authors, Leonid Gorelik, Richard A Flavell, Ralph Weissleder, Harald von Boehmer, Khashayarsha Khazaie. less Proc Natl Acad Sci U S A, 2004 Dec 30; 102(2). PMID: 15623559 Free PMC article. Highly Cited.
|
Coordinated regulation of myeloid cells by tumours. Dmitry I Gabrilovich, Suzanne Ostrand-Rosenberg, Vincenzo Bronte. Nat Rev Immunol, 2012 Mar 23; 12(4). PMID: 22437938 Free PMC article. Highly Cited. Review.
|