. 2020 Oct;6().
doi: 10.1038/s41523-020-00188-3.

Clinical utility of genomic signatures in young breast cancer patients: a systematic review

Cynthia Villarreal-Garza 1 Ana S Ferrigno 1 Cynthia De la Garza-Ramos 1 Regina Barragan-Carrillo 2 Matteo Lambertini 3 Hatem A Azim 1 
  • PMID: 33062888
  •     40 References


Risk stratification by genomic signatures has been shown to improve prognostication and guide treatment decisions among patients with hormone-sensitive breast cancer. However, their role in young women has not been fully elucidated. In this review, a systematic search was conducted for published articles and abstracts from major congresses that evaluated the use of genomic signatures in young breast cancer patients. A total of 71 studies were analyzed, including 561,188 patients of whom 27,748 (4.9%) were young. Women aged ≤40 years were subjected to genomic testing at a similar rate to older women but had a higher proportion of intermediate- to high-risk tumors when classified by EndoPredict (p = 0.04), MammaPrint (p < 0.01), and Oncotype DX (p < 0.01). In young women with low genomic risk, 6-year distant recurrence-free survival was 94%, while 5-year overall survival was nearly 100%. Nonetheless, young patients classified as low-risk had a higher tendency to receive chemotherapy compared to their older counterparts. In conclusion, genomic tests are useful tools for identifying young patients in whom chemotherapy omission is appropriate.

Keywords: Breast cancer; Cancer genomics.

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