Tumor-infiltrating CD8+ T cell antitumor efficacy and exhaustion: molecular insights

Sandeep Kumar ¹, Sunil Kumar Singh ², Basabi Rana ³, Ajay Rana ³

Affiliations

¹ Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, IL 60612, USA. Electronic address: ksandeep@uic.edu.
² Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, IL 60612, USA.
³ Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, IL 60612, USA; University of Illinois Hospital & Health Sciences System Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA; Jesse Brown VA Medical Center, Chicago, IL 60612, USA.

PMID: 33450394
207 References
4 citations

Abstract

Host immunity has an essential role in the clinical management of cancers. Therefore, it is advantageous to choose therapies that can promote tumor cell death and concurrently boost host immunity. The dynamic tumor microenvironment (TME) determines whether an antineoplastic drug will elicit favorable or disparaging immune responses from tumor-infiltrating lymphocytes (TILs). CD8+ T cells are one of the primary tumor-infiltrating immune cells that deliver antitumor responses. Here, we review the influence of various factors in the TME on CD8+ T cell exhaustion and survival, and possible strategies for restoring CD8+ T cell effector function through immunotherapy.

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2B4 but not PD-1 blockade improves mortality in septic animals with preexisting malignancy. Ching-Wen Chen, Ming Xue, +3 authors, Mandy L Ford. less JCI Insight, 2019 Nov 15; 4(22). PMID: 31723059 Free PMC article.
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates. Yannick Simoni, Etienne Becht, +29 authors, Evan W Newell. less Nature, 2018 May 18; 557(7706). PMID: 29769722 Highly Cited.
A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease. Xilai Ding, Guanglin Bian, +7 authors, Xuefang Cao. less J Immunol, 2012 Oct 10; 189(10). PMID: 23045613
Polymeric nanoparticles encapsulating novel TLR7/8 agonists as immunostimulatory adjuvants for enhanced cancer immunotherapy. Hyunjoon Kim, Lin Niu, +6 authors, Jayanth Panyam. less Biomaterials, 2018 Feb 27; 164. PMID: 29482062
IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells. Alistair Noble, Hema Mehta, +2 authors, Lynette Fairbanks. less Eur J Immunol, 2016 Mar 19; 46(6). PMID: 26990545 Free PMC article.
The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. R Salgado, C Denkert, +30 authors, International TILs Working Group 2014. less Ann Oncol, 2014 Sep 13; 26(2). PMID: 25214542 Free PMC article. Highly Cited.
NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models. Deborah H Charych, Ute Hoch, +19 authors, Stephen K Doberstein. less Clin Cancer Res, 2016 Feb 03; 22(3). PMID: 26832745 Highly Cited.
Five-Year Survival and Correlates Among Patients With Advanced Melanoma, Renal Cell Carcinoma, or Non-Small Cell Lung Cancer Treated With Nivolumab. Suzanne L Topalian, F Stephen Hodi, +17 authors, Mario Sznol. less JAMA Oncol, 2019 Jul 26; 5(10). PMID: 31343665 Free PMC article. Highly Cited.
T cell exhaustion. E John Wherry. Nat Immunol, 2011 Jul 09; 12(6). PMID: 21739672 Highly Cited. Review.
Co-administration of α-GalCer analog and TLR4 agonist induces robust CD8(+) T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells. Jordana G Coelho-Dos-Reis, Jing Huang, +5 authors, Moriya Tsuji. less Clin Immunol, 2016 May 02; 168. PMID: 27132023 Free PMC article.
The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD-1, PD-L1, and CTLA-4. Li Liu, Patrick A Mayes, +12 authors, Axel Hoos. less Clin Cancer Res, 2015 Jan 16; 21(7). PMID: 25589619 Highly Cited.
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Roger Geiger, Jan C Rieckmann, +10 authors, Antonio Lanzavecchia. less Cell, 2016 Oct 22; 167(3). PMID: 27745970 Free PMC article. Highly Cited.
Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Qing Zhou, Meghan E Munger, +8 authors, Bruce R Blazar. less Blood, 2011 Mar 10; 117(17). PMID: 21385853 Free PMC article. Highly Cited.
Regulation of DC development and DC-mediated T-cell immunity via CISH. Mohammad Alam Miah, Yong-Soo Bae. Oncoimmunology, 2013 Jun 27; 2(3). PMID: 23802082 Free PMC article.
Differential contribution of three immune checkpoint (VISTA, CTLA-4, PD-1) pathways to antitumor responses against squamous cell carcinoma. Yuta Kondo, Tatsukuni Ohno, +3 authors, Miyuki Azuma. less Oral Oncol, 2016 May 22; 57. PMID: 27208845
Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1. Marine Leclerc, Elodie Voilin, +5 authors, Fathia Mami-Chouaib. less Nat Commun, 2019 Jul 28; 10(1). PMID: 31350404 Free PMC article.
Unraveling V(D)J recombination; insights into gene regulation. David Jung, Frederick W Alt. Cell, 2004 Jan 28; 116(2). PMID: 14744439 Review.
T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma. Karolina Woroniecka, Pakawat Chongsathidkiet, +19 authors, Peter E Fecci. less Clin Cancer Res, 2018 Feb 14; 24(17). PMID: 29437767 Free PMC article. Highly Cited.
The prognostic and predictive value of tumor-infiltrating lymphocytes and hematologic parameters in patients with breast cancer. Kwan Ho Lee, Eun Young Kim, +4 authors, Chan Heun Park. less BMC Cancer, 2018 Oct 05; 18(1). PMID: 30285668 Free PMC article.
Blocking Tumor Necrosis Factor α Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma. Florie Bertrand, Julia Rochotte, +9 authors, Bruno Ségui. less Cancer Res, 2015 May 16; 75(13). PMID: 25977337
STING pathway agonism as a cancer therapeutic. Blake A Flood, Emily F Higgs, +2 authors, Shuyin Li, Jason J Luke, Thomas F Gajewski. less Immunol Rev, 2019 Jul 30; 290(1). PMID: 31355488 Free PMC article. Review.
IL-18 receptor marks functional CD8+ T cells in non-small cell lung cancer. Eleonora Timperi, Chiara Focaccetti, +11 authors, Vincenzo Barnaba. less Oncoimmunology, 2017 Aug 16; 6(7). PMID: 28811967 Free PMC article.
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. Laura M McLane, Mohamed S Abdel-Hakeem, E John Wherry. Annu Rev Immunol, 2019 Jan 25; 37. PMID: 30676822 Highly Cited. Review.
T-cell Homing Therapy for Reducing Regulatory T Cells and Preserving Effector T-cell Function in Large Solid Tumors. Jiemiao Hu, Chuang Sun, +4 authors, Shulin Li. less Clin Cancer Res, 2018 Feb 03; 24(12). PMID: 29391351 Free PMC article.
Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. Fumi Sato-Kaneko, Shiyin Yao, +14 authors, Ezra Ew Cohen. less JCI Insight, 2017 Sep 22; 2(18). PMID: 28931759 Free PMC article. Highly Cited.
Aberrant upregulation of PDK1 in ovarian cancer cells impairs CD8+ T cell function and survival through elevation of PD-L1. Jing-Jing Wang, Michelle K Siu, +6 authors, Karen K Chan. less Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646108 Free PMC article.
Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. Paul F Robbins, Richard A Morgan, +18 authors, Steven A Rosenberg. less J Clin Oncol, 2011 Feb 02; 29(7). PMID: 21282551 Free PMC article. Highly Cited.
Nivolumab Monotherapy for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer. Scott Gettinger, Naiyer A Rizvi, +13 authors, Matthew D Hellmann. less J Clin Oncol, 2016 Jun 30; 34(25). PMID: 27354485 Free PMC article. Highly Cited.
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade. Brian C Miller, Debattama R Sen, +24 authors, W Nicholas Haining. less Nat Immunol, 2019 Feb 20; 20(3). PMID: 30778252 Free PMC article. Highly Cited.
VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Hailing Lu, Gregory N Dietsch, +9 authors, Robert M Hershberg. less Clin Cancer Res, 2011 Dec 01; 18(2). PMID: 22128302
Metabolism of activated T lymphocytes. Jason A Maciolek, J Alex Pasternak, Heather L Wilson. Curr Opin Immunol, 2014 Feb 22; 27. PMID: 24556090 Highly Cited. Review.
Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals. Xiaojing Liu, Daniel E Cooper, +10 authors, Jason W Locasale. less Cell, 2018 Sep 25; 175(2). PMID: 30245009 Free PMC article. Highly Cited.
Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice. H Nishimura, T Honjo, N Minato. J Exp Med, 2000 Mar 08; 191(5). PMID: 10704469 Free PMC article.
Cross-talk between 4-1BB and TLR1-TLR2 Signaling in CD8+ T Cells Regulates TLR2's Costimulatory Effects. Ann Mary Joseph, Ratika Srivastava, Jovanny Zabaleta, Eduardo Davila. Cancer Immunol Res, 2016 Jun 09; 4(8). PMID: 27267778 Free PMC article.
Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Maria Vittoria Dieci, Nina Radosevic-Robin, +26 authors, International Immuno-Oncology Biomarker Working Group on Breast Cancer. less Semin Cancer Biol, 2017 Oct 13; 52(Pt 2). PMID: 29024776 Highly Cited. Review.
STING signaling is a potential immunotherapeutic target in colorectal cancer. Hong Jae Chon, Hyojoong Kim, +9 authors, Chan Kim. less J Cancer, 2019 Oct 11; 10(20). PMID: 31598165 Free PMC article.
TLR Stimulation during T-cell Activation Lowers PD-1 Expression on CD8+ T Cells. Christopher D Zahm, Viswa T Colluru, +2 authors, Sean J McIlwain, Irene M Ong, Douglas G McNeel. less Cancer Immunol Res, 2018 Sep 12; 6(11). PMID: 30201735 Free PMC article.
Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy. Zinal S Chheda, Gary Kohanbash, +21 authors, Hideho Okada. less J Exp Med, 2017 Dec 06; 215(1). PMID: 29203539 Free PMC article. Highly Cited.
Enhanced clinical-scale manufacturing of TCR transduced T-cells using closed culture system modules. Jianjian Jin, Nikolaos Gkitsas, +5 authors, Steven L Highfill. less J Transl Med, 2018 Jan 26; 16(1). PMID: 29368612 Free PMC article.
Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity. Purnima Bhat, Graham Leggatt, Nigel Waterhouse, Ian H Frazer. Cell Death Dis, 2017 Jun 02; 8(6). PMID: 28569770 Free PMC article. Highly Cited.
TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Dori A Thomas, Joan Massagué. Cancer Cell, 2005 Nov 16; 8(5). PMID: 16286245 Highly Cited.
TLR9 acts as a sensor for tumor-released DNA to modulate anti-tumor immunity after chemotherapy. Tae Heung Kang, Chih-Ping Mao, +7 authors, Chien-Fu Hung. less J Immunother Cancer, 2019 Oct 18; 7(1). PMID: 31619293 Free PMC article.
Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model. S Ehl, J Hombach, +2 authors, P Aichele, H Hengartner, R M Zinkernagel. less J Exp Med, 1997 Apr 07; 185(7). PMID: 9104811 Free PMC article.
Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment. Thomas F Gajewski, Leticia Corrales, +3 authors, Stefani Spranger. less Adv Exp Med Biol, 2017 Dec 25; 1036. PMID: 29275462 Free PMC article. Review.
CD70 and PD-L1 in anaplastic thyroid cancer - promising targets for immunotherapy. Karen Zwaenepoel, Julie Jacobs, +7 authors, Patrick Pauwels. less Histopathology, 2017 Apr 07; 71(3). PMID: 28383817
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade. Spencer C Wei, Jacob H Levine, +8 authors, James P Allison. less Cell, 2017 Aug 15; 170(6). PMID: 28803728 Free PMC article. Highly Cited.
An increased number of PD-1+ and Tim-3+ CD8+ T cells is involved in immune evasion in gastric cancer. Shuichi Takano, Hiroaki Saito, Masahide Ikeguchi. Surg Today, 2016 Jan 24; 46(11). PMID: 26801344
LFA-1 regulates CD8+ T cell activation via T cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathways. Dan Li, Jeffrey J Molldrem, Qing Ma. J Biol Chem, 2009 Jun 02; 284(31). PMID: 19483086 Free PMC article.
Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment. Helena Harlin, Yuru Meng, +5 authors, Thomas F Gajewski. less Cancer Res, 2009 Mar 19; 69(7). PMID: 19293190 Free PMC article. Highly Cited.
Tumor infiltrating lymphocyte therapy for ovarian cancer and renal cell carcinoma. Rikke Andersen, Marco Donia, +3 authors, Inge Marie Svane. less Hum Vaccin Immunother, 2015 Aug 27; 11(12). PMID: 26308285 Free PMC article.
CD70 expression correlates with a worse prognosis in malignant pleural mesothelioma patients via immune evasion and enhanced invasiveness. Shingo Inaguma, Jerzy Lasota, +11 authors, Hiroshi Ikeda. less J Pathol, 2019 Oct 23; 250(2). PMID: 31639216 Free PMC article.
Molecular and genetic properties of tumors associated with local immune cytolytic activity. Michael S Rooney, Sachet A Shukla, +2 authors, Catherine J Wu, Gad Getz, Nir Hacohen. less Cell, 2015 Jan 17; 160(1-2). PMID: 25594174 Free PMC article. Highly Cited.
The heterogeneity of tumor-infiltrating CD8+ T cells in metastatic melanoma distorts their quantification: how to manage heterogeneity? Joseph M Obeid, Yinin Hu, +2 authors, Gulsun Erdag, Katie M Leick, Craig L Slingluff. less Melanoma Res, 2017 Jan 25; 27(3). PMID: 28118270
CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition. Elizabeth I Buchbinder, Anupam Desai. Am J Clin Oncol, 2015 Nov 13; 39(1). PMID: 26558876 Free PMC article. Highly Cited. Review.
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Mojgan Ahmadzadeh, Laura A Johnson, +4 authors, Steven A Rosenberg. less Blood, 2009 May 09; 114(8). PMID: 19423728 Free PMC article. Highly Cited.
MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade. Peter J R Ebert, Jeanne Cheung, +9 authors, Ira Mellman. less Immunity, 2016 Mar 06; 44(3). PMID: 26944201 Highly Cited.
Infiltration of CD8+ T cells into tumor cell clusters in triple-negative breast cancer. Xuefei Li, Tina Gruosso, +6 authors, Herbert Levine. less Proc Natl Acad Sci U S A, 2019 Feb 09; 116(9). PMID: 30733298 Free PMC article.
CD160 expression on CD8+ T cells is associated with active effector responses but limited activation potential in pancreatic cancer. Songyang Liu, Wei Zhang, Kai Liu, Yingchao Wang. Cancer Immunol Immunother, 2020 Feb 15; 69(5). PMID: 32055919
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression. Asis Palazon, Petros A Tyrakis, +13 authors, Randall S Johnson. less Cancer Cell, 2017 Nov 15; 32(5). PMID: 29136509 Free PMC article. Highly Cited.
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Frederick Arce Vargas, Andrew J S Furness, +32 authors, Sergio A Quezada. less Cancer Cell, 2018 Mar 27; 33(4). PMID: 29576375 Free PMC article. Highly Cited.
Phosphorylated ERK is a potential prognostic biomarker for Sorafenib response in hepatocellular carcinoma. Yuelong Liang, Jiang Chen, +8 authors, Xiujun Cai. less Cancer Med, 2017 Oct 17; 6(12). PMID: 29030911 Free PMC article.
Quantifying tumor-infiltrating immune cells from transcriptomics data. Francesca Finotello, Zlatko Trajanoski. Cancer Immunol Immunother, 2018 Mar 16; 67(7). PMID: 29541787 Free PMC article. Highly Cited. Review.
The Emerging Role of CD8+ Tissue Resident Memory T (TRM) Cells in Antitumor Immunity: A Unique Functional Contribution of the CD103 Integrin. Stéphanie Corgnac, Marie Boutet, +2 authors, Maria Kfoury, Charles Naltet, Fathia Mami-Chouaib. less Front Immunol, 2018 Aug 31; 9. PMID: 30158938 Free PMC article. Review.
Lack of immunoediting in murine pancreatic cancer reversed with neoantigen. Rebecca A Evans, Mark S Diamond, +10 authors, Robert H Vonderheide. less JCI Insight, 2016 Sep 20; 1(14). PMID: 27642636 Free PMC article. Highly Cited.
Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure). J M Kim, D S Chen. Ann Oncol, 2016 May 22; 27(8). PMID: 27207108 Highly Cited. Review.
CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire. Johan Verhagen, Raphaël Genolet, +5 authors, David C Wraith. less Proc Natl Acad Sci U S A, 2012 Dec 26; 110(3). PMID: 23267099 Free PMC article.
Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion. Bertram Bengsch, Andy L Johnson, +8 authors, E John Wherry. less Immunity, 2016 Aug 09; 45(2). PMID: 27496729 Free PMC article. Highly Cited.
Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer. Jung-Eun Jang, Cristina H Hajdu, +3 authors, Dafna Bar-Sagi. less Cell Rep, 2017 Jul 21; 20(3). PMID: 28723561 Free PMC article. Highly Cited.
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. Suzanne L Topalian, F Stephen Hodi, +27 authors, Mario Sznol. less N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658127 Free PMC article. Highly Cited.
Phenotypic T cell exhaustion in a murine model of bacterial infection in the setting of pre-existing malignancy. Rohit Mittal, Maylene Wagener, +6 authors, Mandy L Ford. less PLoS One, 2014 May 07; 9(5). PMID: 24796533 Free PMC article.
T-cell death and cancer immune tolerance. B Lu, O J Finn. Cell Death Differ, 2007 Nov 17; 15(1). PMID: 18007660 Review.
Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy. Imran Siddiqui, Karin Schaeuble, +10 authors, Werner Held. less Immunity, 2019 Jan 13; 50(1). PMID: 30635237 Highly Cited.
Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer. Sathana Dushyanthen, Zhi Ling Teo, +15 authors, Sherene Loi. less Nat Commun, 2017 Sep 21; 8(1). PMID: 28928458 Free PMC article.
CTLA-4 blockade boosts the expansion of tumor-reactive CD8+ tumor-infiltrating lymphocytes in ovarian cancer. Christina Friese, Katja Harbst, +7 authors, Özcan Met. less Sci Rep, 2020 Mar 05; 10(1). PMID: 32127601 Free PMC article.
CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review. Bagher Farhood, Masoud Najafi, Keywan Mortezaee. J Cell Physiol, 2018 Dec 07; 234(6). PMID: 30520029 Highly Cited. Review.
The PD-1-PD-L pathway in immunological tolerance. Taku Okazaki, Tasuku Honjo. Trends Immunol, 2006 Feb 28; 27(4). PMID: 16500147 Highly Cited. Review.
Intratumoral Delivery of Interferonγ-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo. Theresa Relation, Tai Yi, +6 authors, Edwin M Horwitz. less Stem Cells, 2018 Feb 13; 36(6). PMID: 29430789
Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity. Sandeep Kumar, Sunil Kumar Singh, +10 authors, Ajay Rana. less Proc Natl Acad Sci U S A, 2020 Mar 27; 117(14). PMID: 32209667 Free PMC article.
The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function. Kristin A Hogquist, Stephen C Jameson. Nat Immunol, 2014 Aug 20; 15(9). PMID: 25137456 Free PMC article. Highly Cited. Review.
Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity. Xian-Yang Li, Achim K Moesta, +27 authors, Mark J Smyth. less Cancer Discov, 2019 Nov 09; 9(12). PMID: 31699796 Free PMC article.
TLR1/2 Specific Small-Molecule Agonist Suppresses Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes. Xiaohong Cen, Gengzhen Zhu, +8 authors, Kui Cheng. less Adv Sci (Weinh), 2019 May 28; 6(10). PMID: 31131189 Free PMC article.
Targeting the Antibody Checkpoints to Enhance Cancer Immunotherapy-Focus on FcγRIIB. Ingrid Teige, Linda Mårtensson, Björn L Frendéus. Front Immunol, 2019 Apr 02; 10. PMID: 30930905 Free PMC article. Review.
Phase Ib Study of Immune Biomarker Modulation with Neoadjuvant Cetuximab and TLR8 Stimulation in Head and Neck Cancer to Overcome Suppressive Myeloid Signals. Gulidanna Shayan, Benjamin A Kansy, +11 authors, Robert L Ferris. less Clin Cancer Res, 2017 Oct 25; 24(1). PMID: 29061643 Free PMC article.
Antibodies to watch in 2020. Hélène Kaplon, Mrinalini Muralidharan, Zita Schneider, Janice M Reichert. MAbs, 2019 Dec 19; 12(1). PMID: 31847708 Free PMC article. Highly Cited. Review.
TLR3 agonists improve the immunostimulatory potential of cetuximab against EGFR+ head and neck cancer cells. Chwee Ming Lim, Ryan Stephenson, Andres M Salazar, Robert L Ferris. Oncoimmunology, 2013 Jul 31; 2(6). PMID: 23894722 Free PMC article.
Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy. Huiying Han, Atul D Jain, +17 authors, Sarki A Abdulkadir. less Cancer Cell, 2019 Nov 05; 36(5). PMID: 31679823 Free PMC article.
T Cell-Inflamed versus Non-T Cell-Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection. Jonathan A Trujillo, Randy F Sweis, Riyue Bao, Jason J Luke. Cancer Immunol Res, 2018 Sep 06; 6(9). PMID: 30181337 Free PMC article. Highly Cited.
JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. Yunfei Gao, Jian Tao, +7 authors, Zhinan Yin. less J Immunol, 2005 Oct 21; 175(9). PMID: 16237070
Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification. Linda J Valentijn, Jan Koster, +6 authors, Rogier Versteeg. less Proc Natl Acad Sci U S A, 2012 Oct 24; 109(47). PMID: 23091029 Free PMC article. Highly Cited.
Multifaceted Role of BTLA in the Control of CD8+ T-cell Fate after Antigen Encounter. Krit Ritthipichai, Cara L Haymaker, +13 authors, Chantale Bernatchez. less Clin Cancer Res, 2017 Jul 30; 23(20). PMID: 28754817 Free PMC article.
Long-term functionality of TCR-transduced T cells in vivo. Miriam Coccoris, Erwin Swart, +4 authors, Ton N M Schumacher. less J Immunol, 2008 May 06; 180(10). PMID: 18453572
Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function. Sarah L Buchan, Lang Dou, +26 authors, Stephen A Beers. less Immunity, 2018 Nov 18; 49(5). PMID: 30446386
Tumor infiltrating lymphocytes in ovarian cancer. Phillip P Santoiemma, Daniel J Powell. Cancer Biol Ther, 2015 Apr 22; 16(6). PMID: 25894333 Free PMC article. Highly Cited. Review.
Trial Watch-Immunostimulation with cytokines in cancer therapy. Erika Vacchelli, Fernando Aranda, +10 authors, Lorenzo Galluzzi. less Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057468 Free PMC article. Review.
IL-2 intratumoral immunotherapy enhances CD8+ T cells that mediate destruction of tumor cells and tumor-associated vasculature: a novel mechanism for IL-2. Connie Jackaman, Christine S Bundell, +5 authors, Delia J Nelson. less J Immunol, 2003 Nov 11; 171(10). PMID: 14607902
Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells. Lelisa F Gemta, Peter J Siska, +8 authors, Timothy N J Bullock. less Sci Immunol, 2019 Jan 27; 4(31). PMID: 30683669 Free PMC article.
Avelumab, an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast cancer: a phase 1b JAVELIN Solid Tumor study. Luc Y Dirix, Istvan Takacs, +15 authors, Erika P Hamilton. less Breast Cancer Res Treat, 2017 Oct 25; 167(3). PMID: 29063313 Free PMC article. Highly Cited.
The MYC oncogene is a global regulator of the immune response. Stephanie C Casey, Virginie Baylot, Dean W Felsher. Blood, 2018 Mar 09; 131(18). PMID: 29514782 Free PMC article. Review.
Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab. S Michael Chin, Christopher R Kimberlin, +13 authors, Javier Chaparro-Riggers. less Nat Commun, 2018 Nov 10; 9(1). PMID: 30410017 Free PMC article.
Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression. Colt A Egelston, Christian Avalos, +9 authors, Peter P Lee. less Nat Commun, 2018 Oct 18; 9(1). PMID: 30327458 Free PMC article.
Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy. Rami Yossef, Eric Tran, +8 authors, Steven A Rosenberg. less JCI Insight, 2018 Oct 05; 3(19). PMID: 30282837 Free PMC article. Highly Cited.
TGF-beta modulates the functionality of tumor-infiltrating CD8+ T cells through effects on TCR signaling and Spred1 expression. Maria Giovanna di Bari, M E Christine Lutsiak, +6 authors, Helen Sabzevari. less Cancer Immunol Immunother, 2009 Mar 26; 58(11). PMID: 19319531 Free PMC article.
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Ping-Chih Ho, Jessica Dauz Bihuniak, +15 authors, Susan M Kaech. less Cell, 2015 Sep 01; 162(6). PMID: 26321681 Free PMC article. Highly Cited.
ARGX-110, a highly potent antibody targeting CD70, eliminates tumors via both enhanced ADCC and immune checkpoint blockade. Karen Silence, Torsten Dreier, +9 authors, Hans J De Haard. less MAbs, 2014 Feb 05; 6(2). PMID: 24492296 Free PMC article.
Breaking through the central tolerance ceiling to unleash anticancer immune responses. Maureen A Su, Mark S Anderson. Oncoimmunology, 2015 Jan 23; 3(8). PMID: 25610739 Free PMC article.
Molecular Programming of Tumor-Infiltrating CD8+ T Cells and IL15 Resistance. Andrew L Doedens, Mark P Rubinstein, +6 authors, Ananda W Goldrath. less Cancer Immunol Res, 2016 Aug 04; 4(9). PMID: 27485135 Free PMC article.
A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release. Yiyang Xu, Zhiyuan Yang, +11 authors, Cheng Liu. less Cell Discov, 2018 Nov 28; 4. PMID: 30479831 Free PMC article.
Toll-like receptor agonists in cancer therapy. Sylvia Adams. Immunotherapy, 2010 Jun 22; 1(6). PMID: 20563267 Free PMC article. Review.
Adoptive Transfer of MAGE-A4 T-cell Receptor Gene-Transduced Lymphocytes in Patients with Recurrent Esophageal Cancer. Shinichi Kageyama, Hiroaki Ikeda, +20 authors, Hiroshi Shiku. less Clin Cancer Res, 2015 Apr 10; 21(10). PMID: 25855804
VISTA expressed in tumour cells regulates T cell function. Kumuluzi Mulati, Junzo Hamanishi, +14 authors, Masaki Mandai. less Br J Cancer, 2018 Nov 02; 120(1). PMID: 30382166 Free PMC article.
First-in-Human Study of Utomilumab, a 4-1BB/CD137 Agonist, in Combination with Rituximab in Patients with Follicular and Other CD20+ Non-Hodgkin Lymphomas. Ajay K Gopal, Ronald Levy, +13 authors, Nancy L Bartlett. less Clin Cancer Res, 2020 Mar 08; 26(11). PMID: 32144134
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. Julien Fourcade, Zhaojun Sun, +6 authors, Hassane M Zarour. less J Exp Med, 2010 Sep 08; 207(10). PMID: 20819923 Free PMC article. Highly Cited.
The p38 MAPK inhibitor BIRB796 enhances the antitumor effects of VX680 in cervical cancer. Xin Jin, Qingqing Mo, +7 authors, Pingbo Chen. less Cancer Biol Ther, 2016 Apr 16; 17(5). PMID: 27082306 Free PMC article.
Modulation of p38 MAPK signaling enhances dendritic cell activation of human CD4+ Th17 responses to ovarian tumor antigen. Martin J Cannon, Hannah E Goyne, +4 authors, Maurizio Chiriva-Internati. less Cancer Immunol Immunother, 2013 Jan 29; 62(5). PMID: 23354626 Free PMC article.
TGFβ Blockade Augments PD-1 Inhibition to Promote T-Cell-Mediated Regression of Pancreatic Cancer. Daniel R Principe, Alex Park, +8 authors, Ajay Rana. less Mol Cancer Ther, 2018 Dec 28; 18(3). PMID: 30587556 Free PMC article.
Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells. Beatris Mastelic-Gavillet, Blanca Navarro Rodrigo, +23 authors, Selena Vigano. less J Immunother Cancer, 2019 Oct 12; 7(1). PMID: 31601268 Free PMC article.
Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice. Ying Wang, Lijing Su, +17 authors, Bruce Beutler. less Proc Natl Acad Sci U S A, 2018 Aug 29; 115(37). PMID: 30150374 Free PMC article.
Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy. Daniel R Principe, Matthew Narbutis, +12 authors, Ajay Rana. less Cancer Res, 2020 Apr 03; 80(15). PMID: 32238357 Free PMC article.
Chromatin states define tumour-specific T cell dysfunction and reprogramming. Mary Philip, Lauren Fairchild, +11 authors, Andrea Schietinger. less Nature, 2017 May 18; 545(7655). PMID: 28514453 Free PMC article. Highly Cited.
Mutational activation of the epidermal growth factor receptor down-regulates major histocompatibility complex class I expression via the extracellular signal-regulated kinase in non-small cell lung cancer. Satomi Watanabe, Hidetoshi Hayashi, +10 authors, Kazuhiko Nakagawa. less Cancer Sci, 2018 Nov 06; 110(1). PMID: 30390416 Free PMC article.
Urelumab alone or in combination with rituximab in patients with relapsed or refractory B-cell lymphoma. John Timmerman, Charles Herbaux, +17 authors, Ronald Levy. less Am J Hematol, 2020 Feb 14; 95(5). PMID: 32052473 Free PMC article.
New PD-L1 inhibitors in non-small cell lung cancer - impact of atezolizumab. Nagashree Seetharamu, Isabel R Preeshagul, Kevin M Sullivan. Lung Cancer (Auckl), 2017 Aug 02; 8. PMID: 28761384 Free PMC article. Review.
Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors. Jaikumar Duraiswamy, Karen M Kaluza, Gordon J Freeman, George Coukos. Cancer Res, 2013 May 02; 73(12). PMID: 23633484 Free PMC article. Highly Cited.
Mixed lineage kinase-3/JNK1 axis promotes migration of human gastric cancer cells following gastrin stimulation. Prajna Mishra, Subramanian Senthivinayagam, +2 authors, Velusamy Rangasamy, Gautam Sondarva, Basabi Rana. less Mol Endocrinol, 2010 Feb 13; 24(3). PMID: 20150185 Free PMC article.
CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function. Deepak Mittal, Ailin Lepletier, +16 authors, Mark J Smyth. less Cancer Immunol Res, 2019 Mar 22; 7(4). PMID: 30894377 Free PMC article.
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance. Vivek Verma, Rajeev K Shrimali, +25 authors, Samir N Khleif. less Nat Immunol, 2019 Jul 31; 20(9). PMID: 31358999 Free PMC article. Highly Cited.
Targeting Tumors with IL-10 Prevents Dendritic Cell-Mediated CD8+ T Cell Apoptosis. Jian Qiao, Zhida Liu, +10 authors, Yang-Xin Fu. less Cancer Cell, 2019 Jun 12; 35(6). PMID: 31185213
An intra-tumoral niche maintains and differentiates stem-like CD8 T cells. Caroline S Jansen, Nataliya Prokhnevska, +26 authors, Haydn Kissick. less Nature, 2019 Dec 13; 576(7787). PMID: 31827286 Free PMC article. Highly Cited.
Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8+ T cells. Sandeep Kumar, Sunil Kumar Singh, +9 authors, Ajay Rana. less J Immunother Cancer, 2020 Aug 08; 8(2). PMID: 32759234 Free PMC article.
ICOS Costimulation at the Tumor Site in Combination with CTLA-4 Blockade Therapy Elicits Strong Tumor Immunity. Mario Martínez Soldevilla, Helena Villanueva, +10 authors, Fernando Pastor. less Mol Ther, 2019 Aug 14; 27(11). PMID: 31405808 Free PMC article.
A preclinical evaluation of aminopyridines as putative therapeutic agents in the treatment of botulism. L L Simpson. Infect Immun, 1986 Jun 01; 52(3). PMID: 3011675 Free PMC article.
Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers. Oliver M T Pearce, Robin M Delaine-Smith, +22 authors, Frances R Balkwill. less Cancer Discov, 2017 Dec 03; 8(3). PMID: 29196464 Free PMC article. Highly Cited.
A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity. Marta Compte, Seandean Lykke Harwood, +19 authors, Luis Alvarez-Vallina. less Nat Commun, 2018 Nov 18; 9(1). PMID: 30442944 Free PMC article. Highly Cited.
PTEN Loss Promotes Intratumoral Androgen Synthesis and Tumor Microenvironment Remodeling via Aberrant Activation of RUNX2 in Castration-Resistant Prostate Cancer. Yinhui Yang, Yang Bai, +13 authors, Wanhai Xu. less Clin Cancer Res, 2017 Nov 24; 24(4). PMID: 29167276 Free PMC article.
Direct interaction between CD155 and CD96 promotes immunosuppression in lung adenocarcinoma. Hui Zhang, Qianwen Liu, +8 authors, Zunfu Ke. less Cell Mol Immunol, 2020 Sep 13; 18(6). PMID: 32917981 Free PMC article.
Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. Peter J Siska, Kathryn E Beckermann, +15 authors, Jeffrey C Rathmell. less JCI Insight, 2017 Jun 15; 2(12). PMID: 28614802 Free PMC article. Highly Cited.
Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy. Daniel Baumann, Tanja Hägele, +12 authors, Rienk Offringa. less Nat Commun, 2020 May 03; 11(1). PMID: 32358491 Free PMC article.
Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer. Murugan Kalimutho, Debottam Sinha, +7 authors, Kum Kum Khanna. less J Exp Clin Cancer Res, 2019 Feb 20; 38(1). PMID: 30777101 Free PMC article.
Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy. Daniel Shae, Kyle W Becker, +8 authors, John T Wilson. less Nat Nanotechnol, 2019 Jan 22; 14(3). PMID: 30664751 Free PMC article. Highly Cited.
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Jiaxi Wu, Lijun Sun, +4 authors, Zhijian J Chen. less Science, 2012 Dec 22; 339(6121). PMID: 23258412 Free PMC article. Highly Cited.
Evolution of melanoma cross-resistance to CD8+ T cells and MAPK inhibition in the course of BRAFi treatment. Natalia Pieper, Anne Zaremba, +15 authors, Fang Zhao. less Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221038 Free PMC article.
Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients. Seung-Myoung Son, Chang Gok Woo, +12 authors, Hye Sook Han. less Sci Rep, 2020 Sep 02; 10(1). PMID: 32868848 Free PMC article.
A guide to cancer immunotherapy: from T cell basic science to clinical practice. Alex D Waldman, Jill M Fritz, Michael J Lenardo. Nat Rev Immunol, 2020 May 21; 20(11). PMID: 32433532 Free PMC article. Review.
Lenalidomide induces degradation of IKZF1 and IKZF3. Jan Krönke, Slater N Hurst, Benjamin L Ebert. Oncoimmunology, 2015 Jan 23; 3(7). PMID: 25610725 Free PMC article.
The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: relation to central nervous system antitumor immunity. Robert M Prins, Noah Craft, +5 authors, Linda M Liau. less J Immunol, 2005 Dec 21; 176(1). PMID: 16365406
Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer. Sahar M A Mahmoud, Emma Claire Paish, +5 authors, Andrew R Green. less J Clin Oncol, 2011 Apr 13; 29(15). PMID: 21483002 Highly Cited.
Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+ T cells. Shu Wang, Jose Campos, +5 authors, Cristiana Guiducci. less Proc Natl Acad Sci U S A, 2016 Nov 02; 113(46). PMID: 27799536 Free PMC article. Highly Cited.
Hypoxia-Induced VISTA Promotes the Suppressive Function of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment. Jie Deng, Jiannan Li, +12 authors, Rodwell Mabaera. less Cancer Immunol Res, 2019 May 16; 7(7). PMID: 31088847 Free PMC article. Highly Cited.
Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR3 and TLR7/8 ligation. Frances E Pearson, Karshing Chang, +5 authors, Kristen J Radford. less Immunol Cell Biol, 2018 Jan 19; 96(4). PMID: 29344995
Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis. U Dafni, O Michielin, +15 authors, G Coukos. less Ann Oncol, 2019 Oct 01; 30(12). PMID: 31566658 Systematic Review.
Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8. Bei Wang, Wen Zhang, +21 authors, Dimitris Skokos. less Sci Immunol, 2018 Nov 06; 3(29). PMID: 30389797
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Seng-Ryong Woo, Meghan E Turnis, +18 authors, Dario A A Vignali. less Cancer Res, 2011 Dec 22; 72(4). PMID: 22186141 Free PMC article. Highly Cited.
Molecular mechanisms of T-cell tolerance. Roza I Nurieva, Xindong Liu, Chen Dong. Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488895 Free PMC article. Review.
Carboplatin chemoresistance is associated with CD11b+/Ly6C+ myeloid release and upregulation of TIGIT and LAG3/CD160 exhausted T cells. Doxakis Anestakis, Savvas Petanidis, +3 authors, Theodora Katopodi. less Mol Immunol, 2019 Dec 22; 118. PMID: 31862674
Dual TLR agonist nanodiscs as a strong adjuvant system for vaccines and immunotherapy. Rui Kuai, Xiaoqi Sun, +8 authors, James J Moon. less J Control Release, 2018 Apr 28; 282. PMID: 29702142 Free PMC article.
Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology. Keisuke Watanabe, Shunichiro Kuramitsu, Avery D Posey, Carl H June. Front Immunol, 2018 Nov 13; 9. PMID: 30416506 Free PMC article. Highly Cited. Review.
MAP4K4 negatively regulates CD8 T cell-mediated antitumor and antiviral immunity. Emel Esen, Ismail Sergin, +11 authors, Weilan Ye. less Sci Immunol, 2020 Mar 30; 5(45). PMID: 32220977
Inflammatory features of pancreatic cancer highlighted by monocytes/macrophages and CD4+ T cells with clinical impact. Takuya Komura, Yoshio Sakai, +8 authors, Shuichi Kaneko. less Cancer Sci, 2015 Apr 02; 106(6). PMID: 25827621 Free PMC article.
Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira Mellman. Immunity, 2013 Jul 31; 39(1). PMID: 23890059 Highly Cited. Review.
T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses. Alireza Saeidi, Keivan Zandi, +7 authors, Esaki Muthu Shankar. less Front Immunol, 2018 Nov 27; 9. PMID: 30473697 Free PMC article. Highly Cited. Review.
PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer. Constantia Pantelidou, Olmo Sonzogni, +14 authors, Geoffrey I Shapiro. less Cancer Discov, 2019 Apr 25; 9(6). PMID: 31015319 Free PMC article. Highly Cited.
Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia. Dyantha I van der Lee, Rogier M Reijmers, +13 authors, Marieke Griffioen. less J Clin Invest, 2019 Jan 15; 129(2). PMID: 30640174 Free PMC article. Highly Cited.
Discovery of Small Molecules for the Reversal of T Cell Exhaustion. Brett S Marro, Jaroslav Zak, +3 authors, Michael B A Oldstone. less Cell Rep, 2019 Dec 05; 29(10). PMID: 31801090 Free PMC article.
TLR agonists: our best frenemy in cancer immunotherapy. Sabina Kaczanowska, Ann Mary Joseph, Eduardo Davila. J Leukoc Biol, 2013 Mar 12; 93(6). PMID: 23475577 Free PMC article. Highly Cited. Review.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981 Free PMC article. Highly Cited.
Acetate Promotes T Cell Effector Function during Glucose Restriction. Jing Qiu, Matteo Villa, +22 authors, Erika L Pearce. less Cell Rep, 2019 May 16; 27(7). PMID: 31091446 Free PMC article. Highly Cited.
Immunogenicity of pembrolizumab in patients with advanced tumors. Marianne J H van Vugt, Julie A Stone, +12 authors, Tomoko Freshwater. less J Immunother Cancer, 2019 Aug 10; 7(1). PMID: 31395089 Free PMC article.
T-Cell Immunoglobulin Mucin 3 Expression on Tumor Infiltrating Lymphocytes as a Positive Prognosticator in Triple-Negative Breast Cancer. Kyung Do Byun, Hyo Jun Hwang, +5 authors, Jin Sook Jeong. less J Breast Cancer, 2019 Jan 05; 21(4). PMID: 30607162 Free PMC article.
PLAC1-specific TCR-engineered T cells mediate antigen-specific antitumor effects in breast cancer. Qiongshu Li, Muyun Liu, +11 authors, Weibin Liu. less Oncol Lett, 2018 Mar 21; 15(4). PMID: 29556312 Free PMC article.
Tim-3 expression represents dysfunctional tumor infiltrating T cells in renal cell carcinoma. Chen Cai, Yi-Fan Xu, +6 authors, Yinghao Sun. less World J Urol, 2015 Aug 09; 34(4). PMID: 26253654
Preclinical development of T-cell receptor-engineered T-cell therapy targeting the 5T4 tumor antigen on renal cell carcinoma. Yuexin Xu, Alicia J Morales, +4 authors, Scott S Tykodi. less Cancer Immunol Immunother, 2019 Nov 07; 68(12). PMID: 31686124 Free PMC article.
Elements of cancer immunity and the cancer-immune set point. Daniel S Chen, Ira Mellman. Nature, 2017 Jan 20; 541(7637). PMID: 28102259 Highly Cited. Review.
Phenotype molding of stromal cells in the lung tumor microenvironment. Diether Lambrechts, Els Wauters, +15 authors, Bernard Thienpont. less Nat Med, 2018 Jul 11; 24(8). PMID: 29988129 Highly Cited.
A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus-associated Epithelial Cancers. Sanja Stevanović, Sarah R Helman, +10 authors, Christian S Hinrichs. less Clin Cancer Res, 2018 Dec 07; 25(5). PMID: 30518633 Free PMC article.
Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations. Judith A Seidel, Atsushi Otsuka, Kenji Kabashima. Front Oncol, 2018 Apr 13; 8. PMID: 29644214 Free PMC article. Highly Cited. Review.
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody. Danbee Ha, Atsushi Tanaka, +10 authors, Shimon Sakaguchi. less Proc Natl Acad Sci U S A, 2018 Dec 28; 116(2). PMID: 30587582 Free PMC article.
Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma. Aras Toker, Linh T Nguyen, +14 authors, Pamela S Ohashi. less Clin Cancer Res, 2018 Aug 02; 24(22). PMID: 30065096
Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism. Lyse A Norian, Paulo C Rodriguez, +4 authors, Paul M Allen. less Cancer Res, 2009 Mar 19; 69(7). PMID: 19293186 Free PMC article. Highly Cited.
CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor. Qunrui Ye, De-Gang Song, +5 authors, Daniel J Powell. less Clin Cancer Res, 2013 Sep 21; 20(1). PMID: 24045181 Free PMC article. Highly Cited.
STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade. Hannah Yang, Won Suk Lee, +7 authors, Chan Kim. less J Clin Invest, 2019 Jul 26; 129(10). PMID: 31343989 Free PMC article.
IL-15 is a component of the inflammatory milieu in the tumor microenvironment promoting antitumor responses. Rosa M Santana Carrero, Figen Beceren-Braun, +6 authors, Kimberly S Schluns. less Proc Natl Acad Sci U S A, 2018 Dec 28; 116(2). PMID: 30587590 Free PMC article.
Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance. Douglas C Palmer, Geoffrey C Guittard, +17 authors, Nicholas P Restifo. less J Exp Med, 2015 Nov 04; 212(12). PMID: 26527801 Free PMC article.
Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies. Stefanie R Mullins, John P Vasilakos, +16 authors, Robert W Wilkinson. less J Immunother Cancer, 2019 Sep 13; 7(1). PMID: 31511088 Free PMC article.
An agonistic anti-Toll-like receptor 4 monoclonal antibody as an effective adjuvant for cancer immunotherapy. Hiroki Tsukamoto, Kanae Kubota, +5 authors, Yoshihisa Tomioka. less Immunology, 2019 Sep 14; 158(2). PMID: 31515801 Free PMC article.
Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis. Craig M Brackett, Bojidar Kojouharov, +5 authors, Andrei V Gudkov. less Proc Natl Acad Sci U S A, 2016 Feb 03; 113(7). PMID: 26831100 Free PMC article.
PD-1 blockade augments humoral immunity through ICOS-mediated CD4+ T cell instruction. Meiyu Zhang, Liliang Xia, +8 authors, Ying Wang. less Int Immunopharmacol, 2018 Nov 19; 66. PMID: 30448635
LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment. Christopher G Peña, Yuji Nakada, +10 authors, Diego H Castrillon. less J Clin Invest, 2015 Sep 29; 125(11). PMID: 26413869 Free PMC article.
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion. Deepali V Sawant, Hiroshi Yano, +16 authors, Dario A A Vignali. less Nat Immunol, 2019 Apr 03; 20(6). PMID: 30936494 Free PMC article. Highly Cited.
The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function. Robert J Johnston, Laetitia Comps-Agrar, +9 authors, Jane L Grogan. less Cancer Cell, 2014 Dec 04; 26(6). PMID: 25465800 Highly Cited.
Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells. Stefani Spranger, Robbert M Spaapen, +4 authors, Thomas F Gajewski. less Sci Transl Med, 2013 Aug 30; 5(200). PMID: 23986400 Free PMC article. Highly Cited.
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Hiroki Ishikawa, Glen N Barber. Nature, 2008 Aug 30; 455(7213). PMID: 18724357 Free PMC article. Highly Cited.
The coordination of T-cell function by serine/threonine kinases. David Finlay, Doreen Cantrell. Cold Spring Harb Perspect Biol, 2011 Mar 23; 3(1). PMID: 21421912 Free PMC article.
Sorafenib-resistant hepatocellular carcinoma stratified by phosphorylated ERK activates PD-1 immune checkpoint. Jiang Chen, Tong Ji, +11 authors, Xiujun Cai. less Oncotarget, 2016 Apr 30; 7(27). PMID: 27129180 Free PMC article.
Combination anti-CTLA-4 plus anti-PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies. Spencer C Wei, Nana-Ama A S Anang, +8 authors, James P Allison. less Proc Natl Acad Sci U S A, 2019 Oct 23; 116(45). PMID: 31636208 Free PMC article.
Tumor masses support naive T cell infiltration, activation, and differentiation into effectors. Elizabeth D Thompson, Hilda L Enriquez, Yang-Xin Fu, Victor H Engelhard. J Exp Med, 2010 Jul 28; 207(8). PMID: 20660615 Free PMC article.
OX40 (CD134) and OX40 ligand, important immune checkpoints in cancer. Juan Deng, Sha Zhao, +4 authors, Yayi He. less Onco Targets Ther, 2019 Oct 01; 12. PMID: 31564917 Free PMC article.
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity. Stefani Spranger, Riyue Bao, Thomas F Gajewski. Nature, 2015 May 15; 523(7559). PMID: 25970248 Highly Cited.
TIGIT Expression Is Associated with T-cell Suppression and Exhaustion and Predicts Clinical Outcome and Anti-PD-1 Response in Follicular Lymphoma. Zhi-Zhang Yang, Hyo Jin Kim, +6 authors, Stephen M Ansell. less Clin Cancer Res, 2020 Jul 08; 26(19). PMID: 32631956
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States. Spencer C Wei, Roshan Sharma, +8 authors, James P Allison. less Immunity, 2019 Mar 31; 50(4). PMID: 30926234 Free PMC article.
Developing neoantigen-targeted T cell-based treatments for solid tumors. Tori N Yamamoto, Rigel J Kishton, Nicholas P Restifo. Nat Med, 2019 Oct 09; 25(10). PMID: 31591590 Highly Cited. Review.
GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity. Youg Raj Thaker, Monika Raab, Klaus Strebhardt, Christopher E Rudd. Nat Commun, 2019 Oct 24; 10(1). PMID: 31641113 Free PMC article.
Impact of chemotactic factors and receptors on the cancer immune infiltrate: a bioinformatics study revealing homogeneity and heterogeneity among patient cohorts. Gautier Stoll, Jonathan Pol, +2 authors, Vassili Soumelis, Laurence Zitvogel, Guido Kroemer. less Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288345 Free PMC article.
In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors. Danny N Khalil, Nathan Suek, +18 authors, Taha Merghoub. less J Clin Invest, 2019 Jul 23; 129(8). PMID: 31329159 Free PMC article.
Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells. Qian Chen, Quanyin Hu, +7 authors, Zhen Gu. less Adv Mater, 2019 Mar 28; 31(23). PMID: 30916367 Free PMC article. Highly Cited.
Reinforce the antitumor activity of CD8+ T cells via glutamine restriction. Shogo Nabe, Takeshi Yamada, +7 authors, Masakatsu Yamashita. less Cancer Sci, 2018 Oct 12; 109(12). PMID: 30302856 Free PMC article.
STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity. Jianwen Pei, Yibo Zhang, +5 authors, Junmin Quan. less Cancer Lett, 2019 Feb 23; 450. PMID: 30790684
Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Ying Zhang, Raj Kurupati, +17 authors, Hildegund C J Ertl. less Cancer Cell, 2017 Sep 13; 32(3). PMID: 28898698 Free PMC article. Highly Cited.

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