Review
. 2021 Jan; 18(3):566-578.
doi: 10.1038/s41423-020-00613-4.

Tumor-associated myeloid cells: diversity and therapeutic targeting

Alberto Mantovani 1 Federica Marchesi 2 Sebastien Jaillon 2 Cecilia Garlanda 2 Paola Allavena 2 
Affiliations
  • PMID: 33473192
  •     235 References
  •     18 citations

Abstract

Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a non-uniform phenotype and diverse functional activities. Both tumor-associated macrophages (TAMs), which are more abundantly represented, and tumor-associated neutrophils (TANs) are known to sustain tumor cell growth and invasion, support neoangiogenesis and suppress anticancer adaptive immune responses. In recent decades, several therapeutic approaches have been implemented in preclinical cancer models to neutralize the tumor-promoting roles of both TAMs and TANs. Some of the most successful strategies have now reached the clinic and are being investigated in clinical trials. In this review, we provide an overview of the recent literature on the ever-growing complexity of the biology of TAMs and TANs and the development of the most promising approaches to target these populations therapeutically in cancer patients.

Keywords: macrophage targeting; tumor microenvironment; tumor-associated macrophages.

Macrophages and therapeutic resistance in cancer.
Brian Ruffell, Lisa M Coussens.
Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858805    Free PMC article.
Highly Cited. Review.
The role of myeloid cells in cancer therapies.
Camilla Engblom, Christina Pfirschke, Mikael J Pittet.
Nat Rev Cancer, 2016 Jun 25; 16(7). PMID: 27339708
Highly Cited. Review.
Tumour-associated macrophages as treatment targets in oncology.
Alberto Mantovani, Federica Marchesi, +2 authors, Paola Allavena.
Nat Rev Clin Oncol, 2017 Jan 25; 14(7). PMID: 28117416    Free PMC article.
Highly Cited. Review.
Targeting macrophages: therapeutic approaches in cancer.
Luca Cassetta, Jeffrey W Pollard.
Nat Rev Drug Discov, 2018 Oct 27; 17(12). PMID: 30361552
Highly Cited. Review.
Macrophages as regulators of tumour immunity and immunotherapy.
David G DeNardo, Brian Ruffell.
Nat Rev Immunol, 2019 Feb 06; 19(6). PMID: 30718830    Free PMC article.
Highly Cited. Review.
Myeloid immunosuppression and immune checkpoints in the tumor microenvironment.
Kyohei Nakamura, Mark J Smyth.
Cell Mol Immunol, 2019 Oct 16; 17(1). PMID: 31611651    Free PMC article.
Highly Cited. Review.
Unravelling mononuclear phagocyte heterogeneity.
Frédéric Geissmann, Siamon Gordon, +2 authors, Gwendalyn J Randolph.
Nat Rev Immunol, 2010 May 15; 10(6). PMID: 20467425    Free PMC article.
Highly Cited. Review.
Myeloid cell heterogeneity in cancer: not a single cell alike.
Mate Kiss, Sofie Van Gassen, +2 authors, Damya Laoui.
Cell Immunol, 2018 Feb 28; 330. PMID: 29482836
Highly Cited. Review.
Diversity, Mechanisms, and Significance of Macrophage Plasticity.
Massimo Locati, Graziella Curtale, Alberto Mantovani.
Annu Rev Pathol, 2019 Sep 19; 15. PMID: 31530089    Free PMC article.
Highly Cited. Review.
Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN.
Zvi G Fridlender, Jing Sun, +5 authors, Steven M Albelda.
Cancer Cell, 2009 Sep 08; 16(3). PMID: 19732719    Free PMC article.
Highly Cited.
Neutrophils in cancer: neutral no more.
Seth B Coffelt, Max D Wellenstein, Karin E de Visser.
Nat Rev Cancer, 2016 Jun 11; 16(7). PMID: 27282249
Highly Cited. Review.
Neutrophil diversity and plasticity in tumour progression and therapy.
Sebastien Jaillon, Andrea Ponzetta, +3 authors, Alberto Mantovani.
Nat Rev Cancer, 2020 Jul 23; 20(9). PMID: 32694624
Review.
Tissue-Resident Macrophage Ontogeny and Homeostasis.
Florent Ginhoux, Martin Guilliams.
Immunity, 2016 Mar 18; 44(3). PMID: 26982352
Highly Cited. Review.
Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities.
Calum C Bain, Catherine A Hawley, +9 authors, Stephen J Jenkins.
Nat Commun, 2016 Jun 14; 7. PMID: 27292029    Free PMC article.
Highly Cited.
Macrophages of distinct origins contribute to tumor development in the lung.
Pierre-Louis Loyher, Pauline Hamon, +11 authors, Alexandre Boissonnas.
J Exp Med, 2018 Sep 12; 215(10). PMID: 30201786    Free PMC article.
Highly Cited.
Ontogeny of Tumor-Associated Macrophages.
Marie Laviron, Alexandre Boissonnas.
Front Immunol, 2019 Aug 17; 10. PMID: 31417566    Free PMC article.
Highly Cited. Review.
The cellular and molecular origin of tumor-associated macrophages.
Ruth A Franklin, Will Liao, +5 authors, Ming O Li.
Science, 2014 May 09; 344(6186). PMID: 24812208    Free PMC article.
Highly Cited.
Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.
Yu Zhu, John M Herndon, +12 authors, David G DeNardo.
Immunity, 2017 Aug 17; 47(2). PMID: 28813661    Free PMC article.
Highly Cited.
Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells.
Annett Müller, Susan Brandenburg, +2 authors, Peter Vajkoczy.
Int J Cancer, 2014 Dec 06; 137(2). PMID: 25477239
The role of microglia and macrophages in glioma maintenance and progression.
Dolores Hambardzumyan, David H Gutmann, Helmut Kettenmann.
Nat Neurosci, 2015 Dec 30; 19(1). PMID: 26713745    Free PMC article.
Highly Cited. Review.
Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer.
Anders Etzerodt, Morgane Moulin, +7 authors, Toby Lawrence.
J Exp Med, 2020 Jan 18; 217(4). PMID: 31951251    Free PMC article.
The chemokine system in cancer biology and therapy.
Alberto Mantovani, Benedetta Savino, +3 authors, Raffaella Bonecchi.
Cytokine Growth Factor Rev, 2009 Dec 17; 21(1). PMID: 20004131
Highly Cited. Review.
Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism.
Mara Mazzoni, Giuseppe Mauro, +11 authors, Angela Greco.
J Exp Clin Cancer Res, 2019 May 23; 38(1). PMID: 31113465    Free PMC article.
Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs.
Chiara Porta, Francesca Maria Consonni, +25 authors, Antonio Sica.
Cancer Res, 2020 Apr 09; 80(13). PMID: 32265223
Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor.
Ilaria Marigo, Erika Bosio, +13 authors, Vincenzo Bronte.
Immunity, 2010 Jul 08; 32(6). PMID: 20605485
Highly Cited.
RORC1 Regulates Tumor-Promoting "Emergency" Granulo-Monocytopoiesis.
Laura Strauss, Sabina Sangaletti, +11 authors, Antonio Sica.
Cancer Cell, 2015 Aug 13; 28(2). PMID: 26267538
Highly Cited.
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
Alberto Mantovani, Silvano Sozzani, +2 authors, Antonio Sica.
Trends Immunol, 2002 Oct 29; 23(11). PMID: 12401408
Highly Cited. Review.
The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance.
Paola Allavena, Antonio Sica, Cecilia Garlanda, Alberto Mantovani.
Immunol Rev, 2008 Mar 28; 222. PMID: 18364000
Highly Cited. Review.
Macrophage activation and polarization: nomenclature and experimental guidelines.
Peter J Murray, Judith E Allen, +22 authors, Thomas A Wynn.
Immunity, 2014 Jul 19; 41(1). PMID: 25035950    Free PMC article.
Highly Cited.
The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis.
Irene Mattiola, Federica Tomay, +21 authors, Massimo Locati.
Nat Immunol, 2019 Jul 03; 20(8). PMID: 31263276    Free PMC article.
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.
Sydney R Gordon, Roy L Maute, +10 authors, Irving L Weissman.
Nature, 2017 May 18; 545(7655). PMID: 28514441    Free PMC article.
Highly Cited.
Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer.
Jorge Blando, Anu Sharma, +20 authors, Padmanee Sharma.
Proc Natl Acad Sci U S A, 2019 Jan 13; 116(5). PMID: 30635425    Free PMC article.
Highly Cited.
Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity.
Shumei Kato, Ryosuke Okamura, +11 authors, Razelle Kurzrock.
Oncoimmunology, 2020 Mar 03; 9(1). PMID: 32117584    Free PMC article.
IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice.
Francesca Walker, Hui-Hua Zhang, +5 authors, Antony W Burgess.
Blood, 2007 Dec 25; 111(8). PMID: 18156493
Neutrophils, from marrow to microbes.
Niels Borregaard.
Immunity, 2010 Nov 26; 33(5). PMID: 21094463
Highly Cited. Review.
Coordinated regulation of myeloid cells by tumours.
Dmitry I Gabrilovich, Suzanne Ostrand-Rosenberg, Vincenzo Bronte.
Nat Rev Immunol, 2012 Mar 23; 12(4). PMID: 22437938    Free PMC article.
Highly Cited. Review.
IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis.
Seth B Coffelt, Kelly Kersten, +8 authors, Karin E de Visser.
Nature, 2015 Mar 31; 522(7556). PMID: 25822788    Free PMC article.
Highly Cited.
Tumour-associated neutrophils in patients with cancer.
Merav E Shaul, Zvi G Fridlender.
Nat Rev Clin Oncol, 2019 Jun 05; 16(10). PMID: 31160735
Highly Cited. Review.
Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy.
Valeria Mollica Poeta, Matteo Massara, Arianna Capucetti, Raffaella Bonecchi.
Front Immunol, 2019 Mar 22; 10. PMID: 30894861    Free PMC article.
Highly Cited. Review.
The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils.
Laura Raccosta, Raffaella Fontana, +24 authors, Vincenzo Russo.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897983    Free PMC article.
Complement in cancer: untangling an intricate relationship.
Edimara S Reis, Dimitrios C Mastellos, +2 authors, John D Lambris.
Nat Rev Immunol, 2017 Sep 19; 18(1). PMID: 28920587    Free PMC article.
Highly Cited. Review.
Context-dependent roles of complement in cancer.
Lubka T Roumenina, Marie V Daugan, +2 authors, Wolf Herman Fridman.
Nat Rev Cancer, 2019 Nov 02; 19(12). PMID: 31666715
Review.
The complexity of neutrophils in health and disease: Focus on cancer.
Silvia Carnevale, Somayehsadat Ghasemi, Anna Rigatelli, Sebastien Jaillon.
Semin Immunol, 2020 Sep 23; 48. PMID: 32958359    Free PMC article.
Review.
CD177+ neutrophils suppress epithelial cell tumourigenesis in colitis-associated cancer and predict good prognosis in colorectal cancer.
Guangxi Zhou, Kangsheng Peng, +10 authors, Zhanju Liu.
Carcinogenesis, 2017 Dec 12; 39(2). PMID: 29228136
Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions.
Maximilien Evrard, Immanuel W H Kwok, +27 authors, Lai Guan Ng.
Immunity, 2018 Feb 22; 48(2). PMID: 29466759
Highly Cited.
Identification of an Early Unipotent Neutrophil Progenitor with Pro-tumoral Activity in Mouse and Human Bone Marrow.
Yanfang Peipei Zhu, Lindsey Padgett, +10 authors, Catherine C Hedrick.
Cell Rep, 2018 Aug 30; 24(9). PMID: 30157427    Free PMC article.
Highly Cited.
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation.
Muhammad Zaeem Noman, Giacomo Desantis, +5 authors, Salem Chouaib.
J Exp Med, 2014 Apr 30; 211(5). PMID: 24778419    Free PMC article.
Highly Cited.
Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma.
Yusheng Cheng, Hui Li, +6 authors, Yang Yang.
Cell Death Dis, 2018 Mar 21; 9(4). PMID: 29556041    Free PMC article.
Highly Cited.
Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses.
Yonit Lavin, Soma Kobayashi, +26 authors, Miriam Merad.
Cell, 2017 May 06; 169(4). PMID: 28475900    Free PMC article.
Highly Cited.
Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species.
Rapolas Zilionis, Camilla Engblom, +15 authors, Allon M Klein.
Immunity, 2019 Apr 14; 50(5). PMID: 30979687    Free PMC article.
Highly Cited.
Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells.
Florian Klemm, Roeltje R Maas, +11 authors, Johanna A Joyce.
Cell, 2020 May 30; 181(7). PMID: 32470396    Free PMC article.
Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes.
Ekaterina Friebel, Konstantina Kapolou, +9 authors, Burkhard Becher.
Cell, 2020 May 30; 181(7). PMID: 32470397
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment.
Elham Azizi, Ambrose J Carr, +16 authors, Dana Pe'er.
Cell, 2018 Jul 03; 174(5). PMID: 29961579    Free PMC article.
Highly Cited.
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.
Sidharth V Puram, Itay Tirosh, +16 authors, Bradley E Bernstein.
Cell, 2017 Dec 05; 171(7). PMID: 29198524    Free PMC article.
Highly Cited.
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.
Itay Tirosh, Benjamin Izar, +34 authors, Levi A Garraway.
Science, 2016 Apr 29; 352(6282). PMID: 27124452    Free PMC article.
Highly Cited.
An Immune Atlas of Clear Cell Renal Cell Carcinoma.
Stéphane Chevrier, Jacob Harrison Levine, +14 authors, Bernd Bodenmiller.
Cell, 2017 May 06; 169(4). PMID: 28475899    Free PMC article.
Highly Cited.
Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis.
Matteo Donadon, Guido Torzilli, +16 authors, Federica Marchesi.
J Exp Med, 2020 Aug 14; 217(11). PMID: 32785653    Free PMC article.
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.
Subhra K Biswas, Alberto Mantovani.
Nat Immunol, 2010 Sep 22; 11(10). PMID: 20856220
Highly Cited. Review.
Patrolling monocytes control tumor metastasis to the lung.
Richard N Hanna, Caglar Cekic, +14 authors, Catherine C Hedrick.
Science, 2015 Oct 24; 350(6263). PMID: 26494174    Free PMC article.
Highly Cited.
The yin-yang of the interaction between myelomonocytic cells and NK cells.
Martina Molgora, Domenico Supino, +4 authors, Cecilia Garlanda.
Scand J Immunol, 2018 Jul 27; 88(3). PMID: 30048003    Free PMC article.
Review.
Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesis.
Ole Helm, Janka Held-Feindt, +10 authors, Susanne Sebens.
Int J Cancer, 2014 Jan 25; 135(4). PMID: 24458546
Highly Cited.
Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis.
Özge Canli, Adele M Nicolas, +8 authors, Florian R Greten.
Cancer Cell, 2017 Dec 13; 32(6). PMID: 29232557
Microenvironmental regulation of metastasis.
Johanna A Joyce, Jeffrey W Pollard.
Nat Rev Cancer, 2009 Mar 13; 9(4). PMID: 19279573    Free PMC article.
Highly Cited. Review.
Single tumor-initiating cells evade immune clearance by recruiting type II macrophages.
Xiaocan Guo, Yang Zhao, +14 authors, Bin Zhao.
Genes Dev, 2017 Feb 23; 31(3). PMID: 28223311    Free PMC article.
Highly Cited.
Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells.
Masahisa Jinushi, Shigeki Chiba, +6 authors, Hideaki Tahara.
Proc Natl Acad Sci U S A, 2011 Jul 13; 108(30). PMID: 21746895    Free PMC article.
Highly Cited.
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages.
Haihui Lu, Karl R Clauser, +8 authors, Robert A Weinberg.
Nat Cell Biol, 2014 Oct 01; 16(11). PMID: 25266422    Free PMC article.
Highly Cited.
The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33.
M Liguori, E Digifico, +15 authors, C Belgiovine.
Cell Mol Immunol, 2020 Jul 31; 18(3). PMID: 32728200    Free PMC article.
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis.
Bin-Zhi Qian, Jiufeng Li, +6 authors, Jeffrey W Pollard.
Nature, 2011 Jun 10; 475(7355). PMID: 21654748    Free PMC article.
Highly Cited.
Pre-metastatic niches: organ-specific homes for metastases.
Héctor Peinado, Haiying Zhang, +14 authors, David Lyden.
Nat Rev Cancer, 2017 Mar 18; 17(5). PMID: 28303905
Highly Cited. Review.
Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.
Lidia Bosurgi, Y Grace Cao, +12 authors, Carla V Rothlin.
Science, 2017 May 13; 356(6342). PMID: 28495875    Free PMC article.
Highly Cited.
Tumor macrophages are pivotal constructors of tumor collagenous matrix.
Ran Afik, Ehud Zigmond, +9 authors, Chen Varol.
J Exp Med, 2016 Nov 05; 213(11). PMID: 27697834    Free PMC article.
Highly Cited.
Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas.
J S Lewis, R J Landers, +2 authors, C E Lewis.
J Pathol, 2000 Sep 27; 192(2). PMID: 11004690
Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.
R D Leek, C E Lewis, +3 authors, A L Harris.
Cancer Res, 1996 Oct 15; 56(20). PMID: 8840975
Highly Cited.
Macrophages regulate the angiogenic switch in a mouse model of breast cancer.
Elaine Y Lin, Jiu-Feng Li, +6 authors, Jeffrey W Pollard.
Cancer Res, 2006 Nov 23; 66(23). PMID: 17114237
Highly Cited.
Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy.
Saul J Priceman, James L Sung, +8 authors, Lily Wu.
Blood, 2009 Dec 17; 115(7). PMID: 20008303    Free PMC article.
Highly Cited.
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis.
Christian Stockmann, Andrew Doedens, +5 authors, Randall S Johnson.
Nature, 2008 Nov 11; 456(7223). PMID: 18997773    Free PMC article.
Highly Cited.
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.
Roberta Mazzieri, Ferdinando Pucci, +8 authors, Michele De Palma.
Cancer Cell, 2011 Apr 13; 19(4). PMID: 21481792
Highly Cited.
Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade.
Martina Schmittnaegel, Nicolò Rigamonti, +8 authors, Michele De Palma.
Sci Transl Med, 2017 Apr 14; 9(385). PMID: 28404865
Highly Cited.
The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression.
Wen Pan, Shu Zhu, +17 authors, Jun Lu.
Immunity, 2017 Aug 17; 47(2). PMID: 28813659    Free PMC article.
Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy.
Terry R Medler, Dhaarini Murugan, +9 authors, Lisa M Coussens.
Cancer Cell, 2018 Oct 10; 34(4). PMID: 30300579    Free PMC article.
Highly Cited.
PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.
Eduardo Bonavita, Stefania Gentile, +21 authors, Alberto Mantovani.
Cell, 2015 Feb 14; 160(4). PMID: 25679762
Highly Cited.
Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer.
Marcello Rubino, Paolo Kunderfranco, +8 authors, Cecilia Garlanda.
Oncoimmunology, 2017 Aug 16; 6(7). PMID: 28811977    Free PMC article.
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma.
Ilona Kryczek, Linhua Zou, +12 authors, Weiping Zou.
J Exp Med, 2006 Apr 12; 203(4). PMID: 16606666    Free PMC article.
Highly Cited.
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
Li Wang, Rotem Rubinstein, +10 authors, Randolph J Noelle.
J Exp Med, 2011 Mar 09; 208(3). PMID: 21383057    Free PMC article.
Highly Cited.
Differential macrophage programming in the tumor microenvironment.
Brian Ruffell, Nesrine I Affara, Lisa M Coussens.
Trends Immunol, 2012 Jan 27; 33(3). PMID: 22277903    Free PMC article.
Highly Cited. Review.
Proteolytic networks in cancer.
Steven D Mason, Johanna A Joyce.
Trends Cell Biol, 2011 Jan 15; 21(4). PMID: 21232958    Free PMC article.
Highly Cited. Review.
Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression.
Farbod Shojaei, Mallika Singh, Jennifer D Thompson, Napoleone Ferrara.
Proc Natl Acad Sci U S A, 2008 Feb 13; 105(7). PMID: 18268320    Free PMC article.
Neutrophils support lung colonization of metastasis-initiating breast cancer cells.
Stefanie K Wculek, Ilaria Malanchi.
Nature, 2015 Dec 10; 528(7582). PMID: 26649828    Free PMC article.
Highly Cited.
Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation.
Michelle B Chen, Cynthia Hajal, +4 authors, Roger D Kamm.
Proc Natl Acad Sci U S A, 2018 Jun 20; 115(27). PMID: 29915060    Free PMC article.
Neutrophils escort circulating tumour cells to enable cell cycle progression.
Barbara Maria Szczerba, Francesc Castro-Giner, +14 authors, Nicola Aceto.
Nature, 2019 Feb 08; 566(7745). PMID: 30728496
Highly Cited.
Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing.
Veronika Butin-Israeli, Triet M Bui, +10 authors, Ronen Sumagin.
J Clin Invest, 2019 Jan 15; 129(2). PMID: 30640176    Free PMC article.
Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer.
Evgeniy B Eruslanov, Pratik S Bhojnagarwala, +11 authors, Sunil Singhal.
J Clin Invest, 2014 Nov 11; 124(12). PMID: 25384214    Free PMC article.
Highly Cited.
Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer.
Sunil Singhal, Pratik S Bhojnagarwala, +12 authors, Evgeniy B Eruslanov.
Cancer Cell, 2016 Jul 05; 30(1). PMID: 27374224    Free PMC article.
Highly Cited.
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Andrea Ponzetta, Roberta Carriero, +20 authors, Sebastien Jaillon.
Cell, 2019 Jul 02; 178(2). PMID: 31257026    Free PMC article.
Highly Cited.
Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils.
Karim Mahiddine, Adam Blaisdell, +3 authors, Adrian Erlebacher.
J Clin Invest, 2019 Oct 11; 130(1). PMID: 31600172    Free PMC article.
Macrophage regulation of tumor responses to anticancer therapies.
Michele De Palma, Claire E Lewis.
Cancer Cell, 2013 Mar 23; 23(3). PMID: 23518347
Highly Cited. Review.
The interaction of anticancer therapies with tumor-associated macrophages.
Alberto Mantovani, Paola Allavena.
J Exp Med, 2015 Mar 11; 212(4). PMID: 25753580    Free PMC article.
Highly Cited. Review.
Macrophages at the crossroads of anticancer strategies.
Nina Cortese, Matteo Donadon, Alessandra Rigamonti, Federica Marchesi.
Front Biosci (Landmark Ed), 2019 May 29; 24(7). PMID: 31136979
Review.
Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics.
Abhishek D Garg, Sanket More, +6 authors, Lorenzo Galluzzi.
Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209573    Free PMC article.
Highly Cited. Review.
Autophagy and cellular immune responses.
Yuting Ma, Lorenzo Galluzzi, Laurence Zitvogel, Guido Kroemer.
Immunity, 2013 Aug 27; 39(2). PMID: 23973220
Highly Cited. Review.
Immunogenic cell death in cancer therapy.
Guido Kroemer, Lorenzo Galluzzi, Oliver Kepp, Laurence Zitvogel.
Annu Rev Immunol, 2012 Nov 20; 31. PMID: 23157435
Highly Cited. Review.
Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents.
Lorenzo Galluzzi, Aitziber Buqué, +2 authors, Guido Kroemer.
Cancer Cell, 2015 Dec 19; 28(6). PMID: 26678337
Highly Cited. Review.
Immunogenic cell death in cancer and infectious disease.
Lorenzo Galluzzi, Aitziber Buqué, +2 authors, Guido Kroemer.
Nat Rev Immunol, 2016 Nov 01; 17(2). PMID: 27748397
Highly Cited. Review.
Dual prognostic significance of tumour-associated macrophages in human pancreatic adenocarcinoma treated or untreated with chemotherapy.
Giuseppe Di Caro, Nina Cortese, +10 authors, Federica Marchesi.
Gut, 2015 Jul 15; 65(10). PMID: 26156960
Tumor-associated macrophages and response to 5-fluorouracil adjuvant therapy in stage III colorectal cancer.
Alberto Malesci, Paolo Bianchi, +13 authors, Luigi Laghi.
Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209561    Free PMC article.
A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers.
Krithika N Kodumudi, Karrune Woan, +3 authors, Julie Y Djeu.
Clin Cancer Res, 2010 Aug 13; 16(18). PMID: 20702612    Free PMC article.
Highly Cited.
Colony-stimulating factor-1 antibody reverses chemoresistance in human MCF-7 breast cancer xenografts.
Patrick Paulus, E Richard Stanley, +2 authors, Seyedhossein Aharinejad.
Cancer Res, 2006 Apr 19; 66(8). PMID: 16618760
Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response.
Camilla Salvagno, Metamia Ciampricotti, +15 authors, Karin E de Visser.
Nat Cell Biol, 2019 Mar 20; 21(4). PMID: 30886344    Free PMC article.
The Immune-microenvironment Confers Chemoresistance of Colorectal Cancer through Macrophage-Derived IL6.
Yuan Yin, Surui Yao, +11 authors, Zhaohui Huang.
Clin Cancer Res, 2017 Sep 21; 23(23). PMID: 28928161
Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.
David G DeNardo, Donal J Brennan, +12 authors, Lisa M Coussens.
Cancer Discov, 2011 Nov 01; 1(1). PMID: 22039576    Free PMC article.
Highly Cited.
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer.
Tanaya Shree, Oakley C Olson, +7 authors, Johanna A Joyce.
Genes Dev, 2011 Dec 14; 25(23). PMID: 22156207    Free PMC article.
Highly Cited.
Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy.
Russell Hughes, Bin-Zhi Qian, +12 authors, Claire E Lewis.
Cancer Res, 2015 Aug 14; 75(17). PMID: 26269531    Free PMC article.
Highly Cited.
Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism.
George S Karagiannis, Jessica M Pastoriza, +13 authors, Maja H Oktay.
Sci Transl Med, 2017 Jul 07; 9(397). PMID: 28679654    Free PMC article.
Highly Cited.
Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy.
Felix Klug, Hridayesh Prakash, +15 authors, Philipp Beckhove.
Cancer Cell, 2013 Nov 12; 24(5). PMID: 24209604
Highly Cited.
Immune Priming of the Tumor Microenvironment by Radiation.
Wen Jiang, Charles K Chan, +2 authors, Stephen M Hahn.
Trends Cancer, 2017 Jul 26; 2(11). PMID: 28741502
Review.
Tumor-Derived CCL2 Mediates Resistance to Radiotherapy in Pancreatic Ductal Adenocarcinoma.
Anusha Kalbasi, Chad Komar, +5 authors, Gregory L Beatty.
Clin Cancer Res, 2016 Jun 30; 23(1). PMID: 27354473    Free PMC article.
Highly Cited.
Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment.
Ann H Klopp, Erika L Spaeth, +6 authors, Frank C Marini.
Cancer Res, 2007 Dec 20; 67(24). PMID: 18089798    Free PMC article.
Highly Cited.
CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer.
Jingying Xu, Jemima Escamilla, +6 authors, Lily Wu.
Cancer Res, 2013 Feb 19; 73(9). PMID: 23418320    Free PMC article.
Highly Cited.
Antibody-Dependent Phagocytosis of Tumor Cells by Macrophages: A Potent Effector Mechanism of Monoclonal Antibody Therapy of Cancer.
Nuray Gül, Marjolein van Egmond.
Cancer Res, 2015 Nov 18; 75(23). PMID: 26573795
Review.
Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions.
David J DiLillo, Jeffrey V Ravetch.
Cancer Immunol Res, 2015 Jul 04; 3(7). PMID: 26138698
Highly Cited. Review.
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets.
R A Clynes, T L Towers, L G Presta, J V Ravetch.
Nat Med, 2000 Mar 31; 6(4). PMID: 10742152
Highly Cited.
An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells.
Nicholas S Wilson, Becky Yang, +17 authors, Avi Ashkenazi.
Cancer Cell, 2011 Jan 22; 19(1). PMID: 21251615
Highly Cited.
The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy.
Junji Uchida, Yasuhito Hamaguchi, +4 authors, Thomas F Tedder.
J Exp Med, 2004 Jun 24; 199(12). PMID: 15210744    Free PMC article.
Highly Cited.
Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV.
Veronique Minard-Colin, Yan Xiu, +5 authors, Thomas F Tedder.
Blood, 2008 May 23; 112(4). PMID: 18495955    Free PMC article.
Pilot study of the mechanism of action of preoperative trastuzumab in patients with primary operable breast tumors overexpressing HER2.
Roberto Gennari, Sylvie Menard, +12 authors, Alberto Costa.
Clin Cancer Res, 2004 Sep 10; 10(17). PMID: 15355889
Highly Cited.
Trastuzumab causes antibody-dependent cellular cytotoxicity-mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance.
Márk Barok, Jorma Isola, +8 authors, János Szöllösi.
Mol Cancer Ther, 2007 Jul 11; 6(7). PMID: 17620435
Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer.
Antonino Musolino, Nadia Naldi, +9 authors, Andrea Ardizzoni.
J Clin Oncol, 2008 Mar 19; 26(11). PMID: 18347005
Highly Cited.
Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma.
Marije B Overdijk, Sandra Verploegen, +8 authors, Paul W H I Parren.
MAbs, 2015 Mar 12; 7(2). PMID: 25760767    Free PMC article.
Highly Cited.
Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma.
Wen-Kai Weng, Ronald Levy.
J Clin Oncol, 2003 Sep 17; 21(21). PMID: 12975461
Highly Cited.
Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan.
Frédéric Bibeau, Evelyne Lopez-Crapez, +9 authors, Florence Boissière-Michot.
J Clin Oncol, 2009 Jan 24; 27(7). PMID: 19164213
Highly Cited.
Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma.
Mark P Chao, Ash A Alizadeh, +17 authors, Ravindra Majeti.
Cell, 2010 Sep 04; 142(5). PMID: 20813259    Free PMC article.
Highly Cited.
The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications.
Mark P Chao, Irving L Weissman, Ravindra Majeti.
Curr Opin Immunol, 2012 Feb 09; 24(2). PMID: 22310103    Free PMC article.
Highly Cited. Review.
Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 "Don't Eat Me" Signals.
Melissa N McCracken, Adriel C Cha, Irving L Weissman.
Clin Cancer Res, 2015 Jun 28; 21(16). PMID: 26116271    Free PMC article.
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Stephen B Willingham, Jens-Peter Volkmer, +41 authors, Irving L Weissman.
Proc Natl Acad Sci U S A, 2012 Mar 28; 109(17). PMID: 22451913    Free PMC article.
Highly Cited.
Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.
Sharareh Gholamin, Siddhartha S Mitra, +31 authors, Samuel H Cheshier.
Sci Transl Med, 2017 Mar 17; 9(381). PMID: 28298418
Highly Cited.
Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies.
Yannick Bulliard, Rose Jolicoeur, +6 authors, Jennifer L Brogdon.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897982    Free PMC article.
Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1.
Dong-Ming Kuang, Qiyi Zhao, +4 authors, Limin Zheng.
J Exp Med, 2009 May 20; 206(6). PMID: 19451266    Free PMC article.
Highly Cited.
Gliomas promote immunosuppression through induction of B7-H1 expression in tumor-associated macrophages.
Orin Bloch, Courtney A Crane, +3 authors, Andrew T Parsa.
Clin Cancer Res, 2013 Apr 25; 19(12). PMID: 23613317    Free PMC article.
Highly Cited.
Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: a proposal for quantitative immune-related pathologic response criteria (irPRC).
T R Cottrell, E D Thompson, +27 authors, J M Taube.
Ann Oncol, 2018 Jul 10; 29(8). PMID: 29982279    Free PMC article.
Highly Cited.
CCL2 blockade augments cancer immunotherapy.
Zvi G Fridlender, George Buchlis, +9 authors, Steven M Albelda.
Cancer Res, 2009 Dec 24; 70(1). PMID: 20028856    Free PMC article.
CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.
Yu Zhu, Brett L Knolhoff, +7 authors, David G DeNardo.
Cancer Res, 2014 Aug 02; 74(18). PMID: 25082815    Free PMC article.
Highly Cited.
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment.
Elisa Peranzoni, Jean Lemoine, +12 authors, Emmanuel Donnadieu.
Proc Natl Acad Sci U S A, 2018 Apr 11; 115(17). PMID: 29632196    Free PMC article.
Highly Cited.
T cell-induced CSF1 promotes melanoma resistance to PD1 blockade.
Natalie J Neubert, Martina Schmittnaegel, +18 authors, Daniel E Speiser.
Sci Transl Med, 2018 Apr 13; 10(436). PMID: 29643229    Free PMC article.
Highly Cited.
5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity.
Julie Vincent, Grégoire Mignot, +7 authors, François Ghiringhelli.
Cancer Res, 2010 Apr 15; 70(8). PMID: 20388795
Highly Cited.
Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer.
Darya Alizadeh, Malika Trad, +5 authors, Nicolas Larmonier.
Cancer Res, 2013 Nov 08; 74(1). PMID: 24197130    Free PMC article.
Highly Cited.
Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
Mélanie Bruchard, Grégoire Mignot, +12 authors, François Ghiringhelli.
Nat Med, 2012 Dec 04; 19(1). PMID: 23202296
Highly Cited.
Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer.
Maria Rosaria Galdiero, Paolo Bianchi, +14 authors, Sébastien Jaillon.
Int J Cancer, 2016 Mar 05; 139(2). PMID: 26939802
The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer.
Valeria Governa, Emanuele Trella, +14 authors, Giulio C Spagnoli.
Clin Cancer Res, 2017 Jan 22; 23(14). PMID: 28108544
High density of CD66b in primary high-grade ovarian cancer independently predicts response to chemotherapy.
Alberto Posabella, Philipp Köhn, +10 authors, Gad Singer.
J Cancer Res Clin Oncol, 2019 Dec 20; 146(1). PMID: 31853662
Neutrophils, a candidate biomarker and target for radiation therapy?
Antoine Schernberg, Pierre Blanchard, Cyrus Chargari, Eric Deutsch.
Acta Oncol, 2017 Aug 25; 56(11). PMID: 28835188
Review.
Key role for neutrophils in radiation-induced antitumor immune responses: Potentiation with G-CSF.
Tsuguhide Takeshima, Laurentiu M Pop, +3 authors, Raquibul Hannan.
Proc Natl Acad Sci U S A, 2016 Sep 22; 113(40). PMID: 27651484    Free PMC article.
Targeting Macrophage-Recruiting Chemokines as a Novel Therapeutic Strategy to Prevent the Progression of Solid Tumors.
David Argyle, Takanori Kitamura.
Front Immunol, 2018 Nov 30; 9. PMID: 30483271    Free PMC article.
Review.
Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study.
Irene Brana, Antonio Calles, +7 authors, Emiliano Calvo.
Target Oncol, 2014 Jun 15; 10(1). PMID: 24928772
Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial.
Timothy M Nywening, Andrea Wang-Gillam, +18 authors, David C Linehan.
Lancet Oncol, 2016 Apr 09; 17(5). PMID: 27055731    Free PMC article.
Highly Cited.
CSF-1R inhibition alters macrophage polarization and blocks glioma progression.
Stephanie M Pyonteck, Leila Akkari, +17 authors, Johanna A Joyce.
Nat Med, 2013 Sep 24; 19(10). PMID: 24056773    Free PMC article.
Highly Cited.
Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy.
Carola H Ries, Michael A Cannarile, +24 authors, Dominik Rüttinger.
Cancer Cell, 2014 Jun 06; 25(6). PMID: 24898549
Highly Cited.
CSF-1R Inhibitor Development: Current Clinical Status.
Florent Peyraud, Sophie Cousin, Antoine Italiano.
Curr Oncol Rep, 2017 Sep 07; 19(11). PMID: 28875266
Review.
Biology and therapeutic targeting of tumour-associated macrophages.
Tim Beltraminelli, Michele De Palma.
J Pathol, 2020 Feb 23; 250(5). PMID: 32086811
Review.
Trabectedin as a chemotherapy option for patients with BRCA deficiency.
Bradley J Monk, Domenica Lorusso, +4 authors, Maurizio D'Incalci.
Cancer Treat Rev, 2016 Oct 25; 50. PMID: 27710871
Review.
Role of macrophage targeting in the antitumor activity of trabectedin.
Giovanni Germano, Roberta Frapolli, +21 authors, Paola Allavena.
Cancer Cell, 2013 Feb 16; 23(2). PMID: 23410977
Highly Cited.
Depletion of tumor-associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-tumor phenotype.
Simone Borgoni, Andrea Iannello, +4 authors, Paola Cappello.
Oncoimmunology, 2018 Jan 09; 7(2). PMID: 29308326    Free PMC article.
Trabectedin Reveals a Strategy of Immunomodulation in Chronic Lymphocytic Leukemia.
Priyanka Banerjee, Ronghua Zhang, +12 authors, Maria Teresa S Bertilaccio.
Cancer Immunol Res, 2019 Sep 19; 7(12). PMID: 31530560    Free PMC article.
Trabectedin Reduces Skeletal Prostate Cancer Tumor Size in Association with Effects on M2 Macrophages and Efferocytosis.
J D Jones, B P Sinder, +8 authors, L K McCauley.
Neoplasia, 2018 Dec 29; 21(2). PMID: 30591422    Free PMC article.
Antimetastatic and antiangiogenic activity of trabectedin in cutaneous melanoma.
Laura Carminati, Denise Pinessi, +5 authors, Giulia Taraboletti.
Carcinogenesis, 2018 Dec 14; 40(2). PMID: 30544170
The Mononuclear Phagocytic System. Generation of Diversity.
Siamon Gordon, Annette Plüddemann.
Front Immunol, 2019 Aug 27; 10. PMID: 31447860    Free PMC article.
Review.
Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression.
Anders Etzerodt, Kyriaki Tsalkitzi, +9 authors, Toby Lawrence.
J Exp Med, 2019 Aug 04; 216(10). PMID: 31375534    Free PMC article.
Highly Cited.
Cancer-related inflammation: common themes and therapeutic opportunities.
Frances R Balkwill, Alberto Mantovani.
Semin Cancer Biol, 2012 Jan 03; 22(1). PMID: 22210179
Highly Cited. Review.
CD40 Agonist Antibodies in Cancer Immunotherapy.
Robert H Vonderheide.
Annu Rev Med, 2019 Aug 15; 71. PMID: 31412220
Highly Cited. Review.
CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma.
Ranjana Advani, Ian Flinn, +18 authors, Sonali M Smith.
N Engl J Med, 2018 Nov 01; 379(18). PMID: 30380386    Free PMC article.
Highly Cited.
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.
Kipp Weiskopf, Aaron M Ring, +8 authors, K Christopher Garcia.
Science, 2013 Jun 01; 341(6141). PMID: 23722425    Free PMC article.
Highly Cited.
Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses.
Jesse M Jaynes, Rushikesh Sable, +40 authors, Udo Rudloff.
Sci Transl Med, 2020 Feb 14; 12(530). PMID: 32051227    Free PMC article.
Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis.
Anna-Maria Georgoudaki, Kajsa E Prokopec, +14 authors, Mikael C I Karlsson.
Cell Rep, 2016 May 24; 15(9). PMID: 27210762
Highly Cited.
Toll-like receptors and innate immunity.
R Medzhitov.
Nat Rev Immunol, 2002 Mar 22; 1(2). PMID: 11905821
Highly Cited. Review.
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.
Taro Kawai, Shizuo Akira.
Nat Immunol, 2010 Apr 21; 11(5). PMID: 20404851
Highly Cited. Review.
Mechanisms of BCG immunotherapy and its outlook for bladder cancer.
Caroline Pettenati, Molly A Ingersoll.
Nat Rev Urol, 2018 Jul 12; 15(10). PMID: 29991725
Highly Cited. Review.
Percutaneous BCG enhances innate effector antitumor cytotoxicity during treatment of bladder cancer: a translational clinical trial.
Niannian Ji, Neelam Mukherjee, +10 authors, Robert S Svatek.
Oncoimmunology, 2019 Aug 16; 8(8). PMID: 31413921    Free PMC article.
Toll-like Receptors and the Control of Immunity.
Katherine A Fitzgerald, Jonathan C Kagan.
Cell, 2020 Mar 14; 180(6). PMID: 32164908
Review.
Trial Watch: Toll-like receptor agonists in cancer immunotherapy.
Melody Smith, Elena García-Martínez, +5 authors, Lorenzo Galluzzi.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524908    Free PMC article.
Review.
TLR-mediated metabolic reprogramming in the tumor microenvironment: potential novel strategies for cancer immunotherapy.
Lan Huang, Huaxi Xu, Guangyong Peng.
Cell Mol Immunol, 2018 Mar 20; 15(5). PMID: 29553135    Free PMC article.
Highly Cited. Review.
Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN.
Laura Q M Chow, Chihiro Morishima, +9 authors, Renato G Martins.
Clin Cancer Res, 2016 Nov 05; 23(10). PMID: 27810904
Preclinical development of the TLR9 agonist DV281 as an inhaled aerosolized immunotherapeutic for lung cancer: Pharmacological profile in mice, non-human primates, and human primary cells.
Sariah A Kell, Melissa A Kachura, +3 authors, John D Campbell.
Int Immunopharmacol, 2018 Dec 05; 66. PMID: 30502651
SD-101 in Combination with Pembrolizumab in Advanced Melanoma: Results of a Phase Ib, Multicenter Study.
Antoni Ribas, Theresa Medina, +11 authors, Robert S Janssen.
Cancer Discov, 2018 Aug 30; 8(10). PMID: 30154193    Free PMC article.
Highly Cited.
In Situ Vaccination with a TLR9 Agonist and Local Low-Dose Radiation Induces Systemic Responses in Untreated Indolent Lymphoma.
Matthew J Frank, Patrick M Reagan, +9 authors, Ronald Levy.
Cancer Discov, 2018 Aug 30; 8(10). PMID: 30154192    Free PMC article.
PI3Kγ is a molecular switch that controls immune suppression.
Megan M Kaneda, Karen S Messer, +20 authors, Judith A Varner.
Nature, 2016 Nov 01; 539(7629). PMID: 27642729    Free PMC article.
Highly Cited.
Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer.
Andrew J Gunderson, Megan M Kaneda, +15 authors, Lisa M Coussens.
Cancer Discov, 2015 Dec 31; 6(3). PMID: 26715645    Free PMC article.
Highly Cited.
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells.
Olivier De Henau, Matthew Rausch, +21 authors, Taha Merghoub.
Nature, 2016 Nov 10; 539(7629). PMID: 27828943    Free PMC article.
Highly Cited.
Macrophage targeting in cancer.
Martha Lopez-Yrigoyen, Luca Cassetta, Jeffrey W Pollard.
Ann N Y Acad Sci, 2020 May 24; 1499(1). PMID: 32445205
Review.
Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages.
Jennifer L Guerriero, Alaba Sotayo, +11 authors, Anthony Letai.
Nature, 2017 Mar 09; 543(7645). PMID: 28273064    Free PMC article.
Highly Cited.
Epigenetic therapy inhibits metastases by disrupting premetastatic niches.
Zhihao Lu, Jianling Zou, +45 authors, Malcolm V Brock.
Nature, 2020 Feb 28; 579(7798). PMID: 32103175    Free PMC article.
Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity.
Xenia Geeraerts, Evangelia Bolli, Sarah-Maria Fendt, Jo A Van Ginderachter.
Front Immunol, 2017 Apr 01; 8. PMID: 28360914    Free PMC article.
Highly Cited. Review.
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells.
Min-Hee Oh, Im-Hong Sun, +17 authors, Jonathan D Powell.
J Clin Invest, 2020 Apr 24; 130(7). PMID: 32324593    Free PMC article.
From Krebs to clinic: glutamine metabolism to cancer therapy.
Brian J Altman, Zachary E Stine, Chi V Dang.
Nat Rev Cancer, 2016 Aug 06; 16(10). PMID: 27492215    Free PMC article.
Highly Cited. Review.
Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.
Alessio Menga, Marina Serra, +11 authors, Massimiliano Mazzone.
EMBO Mol Med, 2020 Sep 05; 12(10). PMID: 32885605    Free PMC article.
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
Oscar R Colegio, Ngoc-Quynh Chu, +10 authors, Ruslan Medzhitov.
Nature, 2014 Jul 22; 513(7519). PMID: 25043024    Free PMC article.
Highly Cited.
Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.
Peiwen Chen, Hao Zuo, +5 authors, Yihong Wan.
Proc Natl Acad Sci U S A, 2017 Jan 05; 114(3). PMID: 28049847    Free PMC article.
Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer.
Xianmin Mu, Wei Shi, +15 authors, Qiang You.
Cell Cycle, 2018 Feb 23; 17(4). PMID: 29468929    Free PMC article.
Highly Cited.
Adenosine up-regulates vascular endothelial growth factor in human macrophages.
Isabelle Ernens, Frédérique Léonard, +3 authors, Daniel R Wagner.
Biochem Biophys Res Commun, 2010 Jan 14; 392(3). PMID: 20067761
Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment.
Caglar Cekic, Yuan-Ji Day, Duygu Sag, Joel Linden.
Cancer Res, 2014 Nov 08; 74(24). PMID: 25377469    Free PMC article.
Highly Cited.
Control of immune response by amino acid metabolism.
Ursula Grohmann, Vincenzo Bronte.
Immunol Rev, 2010 Jul 20; 236. PMID: 20636821
Review.
Metabolic Regulation of Macrophage Polarization in Cancer.
Kamiya Mehla, Pankaj K Singh.
Trends Cancer, 2019 Dec 10; 5(12). PMID: 31813459    Free PMC article.
Review.
State of the art in CAR T cell therapy for CD19+ B cell malignancies.
Matthew J Frigault, Marcela V Maus.
J Clin Invest, 2020 Apr 03; 130(4). PMID: 32235098    Free PMC article.
Review.
Human chimeric antigen receptor macrophages for cancer immunotherapy.
Michael Klichinsky, Marco Ruella, +23 authors, Saar Gill.
Nat Biotechnol, 2020 May 04; 38(8). PMID: 32361713    Free PMC article.
A CXCL1 paracrine network links cancer chemoresistance and metastasis.
Swarnali Acharyya, Thordur Oskarsson, +10 authors, Joan Massagué.
Cell, 2012 Jul 10; 150(1). PMID: 22770218    Free PMC article.
Highly Cited.
CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma.
Colin W Steele, Saadia A Karim, +23 authors, Jennifer P Morton.
Cancer Cell, 2016 Jun 07; 29(6). PMID: 27265504    Free PMC article.
Highly Cited.
Fatty acid transport protein 2 reprograms neutrophils in cancer.
Filippo Veglia, Vladimir A Tyurin, +22 authors, Dmitry I Gabrilovich.
Nature, 2019 Apr 19; 569(7754). PMID: 30996346    Free PMC article.
Highly Cited.
Loss of CXCR4 in Myeloid Cells Enhances Antitumor Immunity and Reduces Melanoma Growth through NK Cell and FASL Mechanisms.
Jinming Yang, Amrendra Kumar, +5 authors, Ann Richmond.
Cancer Immunol Res, 2018 Aug 16; 6(10). PMID: 30108045    Free PMC article.
Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonist attenuate tumor growth via polarization of neutrophils toward an antitumor phenotype.
Sanjeeb Shrestha, Jae Myoung Noh, +7 authors, Chang-Won Hong.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942086    Free PMC article.
NAMPT signaling is critical for the proangiogenic activity of tumor-associated neutrophils.
Ekaterina Pylaeva, Mozhgan Dehghan Harati, +12 authors, Jadwiga Jablonska.
Int J Cancer, 2018 Aug 20; 144(1). PMID: 30121947
Neutrophils as effector cells for antibody-based immunotherapy of cancer.
Marjolein van Egmond, Jantine E Bakema.
Semin Cancer Biol, 2013 Jan 05; 23(3). PMID: 23287459
Review.
Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG.
Arianne M Brandsma, Sina Bondza, +7 authors, Toine Ten Broeke.
Front Immunol, 2019 Apr 30; 10. PMID: 31031746    Free PMC article.
Anti-CD20 IgA can protect mice against lymphoma development: evaluation of the direct impact of IgA and cytotoxic effector recruitment on CD20 target cells.
Virginie Pascal, Brice Laffleur, +8 authors, Michel Cogné.
Haematologica, 2012 Jun 13; 97(11). PMID: 22689689    Free PMC article.
IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47-SIRPα Checkpoint Inhibition.
Louise W Treffers, Toine Ten Broeke, +12 authors, Hanke L Matlung.
Cancer Immunol Res, 2019 Nov 07; 8(1). PMID: 31690649
Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis.
Hanke L Matlung, Liane Babes, +26 authors, Timo K van den Berg.
Cell Rep, 2018 Jun 28; 23(13). PMID: 29949776
Highly Cited.
Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.
Nan Guo Ring, Dietmar Herndler-Brandstetter, +11 authors, Irving L Weissman.
Proc Natl Acad Sci U S A, 2017 Nov 22; 114(49). PMID: 29158380    Free PMC article.
Highly Cited.
Immune-Checkpoint Protein VISTA Regulates Antitumor Immunity by Controlling Myeloid Cell-Mediated Inflammation and Immunosuppression.
Wenwen Xu, Juan Dong, +10 authors, Li Wang.
Cancer Immunol Res, 2019 Jul 26; 7(9). PMID: 31340983    Free PMC article.
Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma.
Gaixia He, Henghui Zhang, +9 authors, Hui Zeng.
J Exp Clin Cancer Res, 2015 Nov 20; 34. PMID: 26581194    Free PMC article.
Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway.
Ting-Ting Wang, Yong-Liang Zhao, +13 authors, Quan-Ming Zou.
Gut, 2017 Mar 10; 66(11). PMID: 28274999    Free PMC article.
Highly Cited.
Regulation of myeloid cell function through the CD200 receptor.
Maria C Jenmalm, Holly Cherwinski, +2 authors, Jonathon D Sedgwick.
J Immunol, 2005 Dec 21; 176(1). PMID: 16365410
Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation.
Jing Wang, Ikuo Shiratori, +2 authors, Hisashi Arase.
Nat Immunol, 2012 Nov 13; 14(1). PMID: 23142774
Exocytosis acts as a modulator of the ILT4-mediated inhibition of neutrophil functions.
Jeremy Baudhuin, Julie Migraine, +4 authors, Benoit Favier.
Proc Natl Acad Sci U S A, 2013 Oct 18; 110(44). PMID: 24133137    Free PMC article.
Phagocytosis checkpoints as new targets for cancer immunotherapy.
Mingye Feng, Wen Jiang, +3 authors, Irving L Weissman.
Nat Rev Cancer, 2019 Aug 30; 19(10). PMID: 31462760    Free PMC article.
Highly Cited. Review.
Targeted deletion of PD-1 in myeloid cells induces antitumor immunity.
Laura Strauss, Mohamed A A Mahmoud, +8 authors, Vassiliki A Boussiotis.
Sci Immunol, 2020 Jan 05; 5(43). PMID: 31901074    Free PMC article.
ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity.
Matteo Massara, Ornella Bonavita, +10 authors, Raffaella Bonecchi.
Nat Commun, 2018 Feb 16; 9(1). PMID: 29445158    Free PMC article.
Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules.
M Colonna, J Samaridis, +7 authors, A Rolink.
J Immunol, 1998 Apr 08; 160(7). PMID: 9531263
Highly Cited.
Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms.
Ik Sun Kim, Yang Gao, +26 authors, Xiang H-F Zhang.
Nat Cell Biol, 2019 Aug 28; 21(9). PMID: 31451770    Free PMC article.
Highly Cited.
Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma.
Qiming Zhang, Yao He, +22 authors, Zemin Zhang.
Cell, 2019 Nov 02; 179(4). PMID: 31675496
Highly Cited.
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Lei Zhang, Ziyi Li, +26 authors, Xin Yu.
Cell, 2020 Apr 18; 181(2). PMID: 32302573
International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study.
Franck Pagès, Bernhard Mlecnik, +96 authors, Jérôme Galon.
Lancet, 2018 May 15; 391(10135). PMID: 29754777
Highly Cited.
Inhibition of the Histone Methyltransferase EZH2 Enhances Protumor Monocyte Recruitment in Human Mesothelioma Spheroids.
Silvia Mola, Giulia Pinton, +6 authors, Chiara Porta.
Int J Mol Sci, 2021 May 01; 22(9). PMID: 33922336    Free PMC article.
Development and Validation of a Hypoxia-Related Signature for Predicting Survival Outcomes in Patients With Bladder Cancer.
Facai Zhang, Xiaoming Wang, +8 authors, Ping Han.
Front Genet, 2021 Jun 15; 12. PMID: 34122523    Free PMC article.
Tumor-Associated Macrophages: A Potential Target for Cancer Therapy.
Yifan Tan, Min Wang, +4 authors, Chuanyu Sun.
Front Oncol, 2021 Jun 29; 11. PMID: 34178692    Free PMC article.
Review.
Interpreting Immunoregulation in Lung Fibrosis: A New Branch of the Immune Model.
François Huaux.
Front Immunol, 2021 Sep 08; 12. PMID: 34489937    Free PMC article.
Review.
Cervical Cancer Immunotherapy: Facts and Hopes.
Louise Ferrall, Ken Y Lin, +2 authors, T-C Wu.
Clin Cancer Res, 2021 Apr 24; 27(18). PMID: 33888488    Free PMC article.
Review.
Senescent Thyrocytes, Similarly to Thyroid Tumor Cells, Elicit M2-like Macrophage Polarization In Vivo.
Mara Mazzoni, Giuseppe Mauro, +10 authors, Angela Greco.
Biology (Basel), 2021 Oct 24; 10(10). PMID: 34681084    Free PMC article.
Giving Oncolytic Viruses a Free Ride: Carrier Cells for Oncolytic Virotherapy.
Alberto Reale, Arianna Calistri, Jennifer Altomonte.
Pharmaceutics, 2021 Dec 29; 13(12). PMID: 34959474    Free PMC article.
Review.
An Unfolded Protein Response Related Signature Could Robustly Predict Survival Outcomes and Closely Correlate With Response to Immunotherapy and Chemotherapy in Bladder Cancer.
Facai Zhang, Dechao Feng, +8 authors, Ping Han.
Front Mol Biosci, 2022 Jan 11; 8. PMID: 35004850    Free PMC article.
Immunosenescence, Inflammaging, and Frailty: Role of Myeloid Cells in Age-Related Diseases.
Augusto Bleve, Francesca Motta, +3 authors, Antonio Sica.
Clin Rev Allergy Immunol, 2022 Jan 16;. PMID: 35031957    Free PMC article.
Review.
Evolution and Targeting of Myeloid Suppressor Cells in Cancer: A Translational Perspective.
Augusto Bleve, Francesca Maria Consonni, +2 authors, Antonio Sica.
Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158779    Free PMC article.
Review.
Chemokines as Regulators of Neutrophils: Focus on Tumors, Therapeutic Targeting, and Immunotherapy.
Raffaella Bonecchi, Alberto Mantovani, Sebastien Jaillon.
Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158948    Free PMC article.
Review.
Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives.
Thomas Boyer, Céline Blaye, Nicolas Larmonier, Charlotte Domblides.
Cells, 2022 Feb 16; 11(3). PMID: 35159363    Free PMC article.
Review.
PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen.
Mingyu Liu, Chong Wu, +12 authors, Limin Zheng.
J Exp Med, 2022 Mar 11; 219(4). PMID: 35266960    Free PMC article.
B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome.
Wolf H Fridman, Maxime Meylan, +3 authors, Catherine Sautès-Fridman.
Nat Rev Clin Oncol, 2022 Apr 03;. PMID: 35365796
Review.
Carbonic anhydrase XII mediates the survival and prometastatic functions of macrophages in human hepatocellular carcinoma.
Wan-Ru Ning, Da Jiang, +7 authors, Limin Zheng.
J Clin Invest, 2022 Apr 02; 132(7). PMID: 35362480    Free PMC article.
An acid trip activates protumoral macrophages to promote hepatocellular carcinoma malignancy.
Nicola Graham, Jeffrey W Pollard.
J Clin Invest, 2022 Apr 02; 132(7). PMID: 35362482    Free PMC article.
Tumor Immunogenomic Features Determine Outcomes in Patients with Metastatic Colorectal Cancer Treated with Standard-of-Care Combinations of Bevacizumab and Cetuximab.
Federico Innocenti, Akram Yazdani, +9 authors, Benjamin G Vincent.
Clin Cancer Res, 2022 Feb 18; 28(8). PMID: 35176136    Free PMC article.
Immunosuppressive cells in cancer: mechanisms and potential therapeutic targets.
Yan Tie, Fan Tang, Yu-Quan Wei, Xia-Wei Wei.
J Hematol Oncol, 2022 May 19; 15(1). PMID: 35585567    Free PMC article.
Review.