Natural Killer Cells and Anti-Cancer Therapies: Reciprocal Effects on Immune Function and Therapeutic Response

Elisa C Toffoli ¹, Abdolkarim Sheikhi ¹, Yannick D Höppner ¹, Pita de Kok ¹, Mahsa Yazdanpanah-Samani ², Jan Spanholtz ³, Henk M W Verheul ⁴, Hans J van der Vliet ¹, Tanja D de Gruijl ¹

Affiliations

¹ Cancer Center Amsterdam, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
² Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz 71348-45794, Iran.
³ Glycostem, Kloosterstraat 9, 5349 AB Oss, The Netherlands.
⁴ Department of Medical Oncology, Radboud Institute for Health Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.

PMID: 33572396
226 References
6 citations

Abstract

Natural Killer (NK) cells are innate immune cells with the unique ability to recognize and kill virus-infected and cancer cells without prior immune sensitization. Due to their expression of the Fc receptor CD16, effector NK cells can kill tumor cells through antibody-dependent cytotoxicity, making them relevant players in antibody-based cancer therapies. The role of NK cells in other approved and experimental anti-cancer therapies is more elusive. Here, we review the possible role of NK cells in the efficacy of various anti-tumor therapies, including radiotherapy, chemotherapy, and immunotherapy, as well as the impact of these therapies on NK cell function.

Keywords: NK cells; anti-cancer therapies; cancer; checkpoint inhibitors; chemotherapy; local ablation therapies; oncolytic virus; protein kinase inhibitors; radiotherapy.

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Enhancement of NK Cell Antitumor Effector Functions Using a Bispecific Single Domain Antibody Targeting CD16 and the Epidermal Growth Factor Receptor. Elisa C Toffoli, Abdolkarim Sheikhi, +8 authors, Hans J van der Vliet. less Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771609 Free PMC article.
Anesthesia Techniques and Long-Term Oncological Outcomes. Maria F Ramirez, Juan P Cata. Front Oncol, 2021 Dec 28; 11. PMID: 34956903 Free PMC article. Review.
Natural killer cells and immune-checkpoint inhibitor therapy: Current knowledge and new challenges. Alessandro Poggi, Maria Raffaella Zocchi. Mol Ther Oncolytics, 2022 Jan 04; 24. PMID: 34977340 Free PMC article. Review.
Gamma-ray irradiation modulates PGRMC1 expression and the number of CD56+ and FoxP3+ cells in the tumor microenvironment of endometrial endometrioid adenocarcinoma. Dmitry Aleksandrovich Zinovkin, Yulia Anatolievna Lyzikova, +3 authors, Md Zahidul Islam Pranjol. less Radiat Oncol J, 2022 Jan 06; 39(4). PMID: 34986554 Free PMC article.

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