. 2021 Feb; 11:604967.
doi: 10.3389/fimmu.2020.604967.

Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors

Violena Pietrobon 1 Alessandra Cesano 2 Francesco Marincola 1 Jakob Nikolas Kather 3 
  • PMID: 33584676
  •     387 References
  •     3 citations


In recent years, cancer immunotherapy experienced remarkable developments and it is nowadays considered a promising therapeutic frontier against many types of cancer, especially hematological malignancies. However, in most types of solid tumors, immunotherapy efficacy is modest, partly because of the limited accessibility of lymphocytes to the tumor core. This immune exclusion is mediated by a variety of physical, functional and dynamic barriers, which play a role in shaping the immune infiltrate in the tumor microenvironment. At present there is no unified and integrated understanding about the role played by different postulated models of immune exclusion in human solid tumors. Systematically mapping immune landscapes or "topographies" in cancers of different histology is of pivotal importance to characterize spatial and temporal distribution of lymphocytes in the tumor microenvironment, providing insights into mechanisms of immune exclusion. Spatially mapping immune cells also provides quantitative information, which could be informative in clinical settings, for example for the discovery of new biomarkers that could guide the design of patient-specific immunotherapies. In this review, we aim to summarize current standard and next generation approaches to define Cancer Immune Topographies based on published studies and propose future perspectives.

Keywords: deep learning; imaging techniques; immune exclusion; immune topography; single-cell analysis; solid tumors.

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Weijun Wei, Dawei Jiang, +2 authors, Weibo Cai.
Trends Cancer, 2018 May 02; 4(5). PMID: 29709260    Free PMC article.
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J Immunother Cancer, 2020 Mar 29; 8(1). PMID: 32217763    Free PMC article.
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Imaging activated T cells predicts response to cancer vaccines.
Israt S Alam, Aaron T Mayer, +7 authors, Sanjiv S Gambhir.
J Clin Invest, 2018 Mar 30; 128(6). PMID: 29596062    Free PMC article.
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Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging.
Yury Goltsev, Nikolay Samusik, +5 authors, Garry P Nolan.
Cell, 2018 Aug 07; 174(4). PMID: 30078711    Free PMC article.
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Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy.
Tina Cascone, Jodi A McKenzie, +34 authors, Weiyi Peng.
Cell Metab, 2018 Apr 10; 27(5). PMID: 29628419    Free PMC article.
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Immunological mechanisms of the antitumor effects of supplemental oxygenation.
Stephen M Hatfield, Jorgen Kjaergaard, +15 authors, Michail V Sitkovsky.
Sci Transl Med, 2015 Mar 06; 7(277). PMID: 25739764    Free PMC article.
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Targeting VEGF/VEGFR to Modulate Antitumor Immunity.
Ju Yang, Jing Yan, Baorui Liu.
Front Immunol, 2018 May 19; 9. PMID: 29774034    Free PMC article.
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Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives.
Paulo C Rodríguez, Augusto C Ochoa.
Immunol Rev, 2008 Mar 28; 222. PMID: 18364002    Free PMC article.
Highly Cited. Review.
Immune oncology, immune responsiveness and the theory of everything.
Tolga Turan, Deepti Kannan, +14 authors, Josue Samayoa.
J Immunother Cancer, 2018 Jun 07; 6(1). PMID: 29871670    Free PMC article.
Immunoregulatory activity of adenosine and its role in human cancer progression.
Sylvia Muller-Haegele, Laurent Muller, Theresa L Whiteside.
Expert Rev Clin Immunol, 2014 May 30; 10(7). PMID: 24871693
Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade.
Mohammad Rashidian, Martin W LaFleur, +13 authors, Hidde L Ploegh.
Proc Natl Acad Sci U S A, 2019 Aug 04; 116(34). PMID: 31375632    Free PMC article.
High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes.
Mandeep Singh, Ghamdan Al-Eryani, +11 authors, Alexander Swarbrick.
Nat Commun, 2019 Jul 18; 10(1). PMID: 31311926    Free PMC article.
Adoptive immunotherapy of experimental autoimmune encephalomyelitis via T cell delivery of the IL-12 p40 subunit.
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J Immunol, 2001 Aug 08; 167(4). PMID: 11490028
18F-FDG PET/CT for Monitoring of Ipilimumab Therapy in Patients with Metastatic Melanoma.
Kimiteru Ito, Rebecca Teng, +7 authors, Wolfgang A Weber.
J Nucl Med, 2018 Nov 11; 60(3). PMID: 30413661    Free PMC article.
Immunomodulatory Activity of VEGF in Cancer.
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Int Rev Cell Mol Biol, 2017 Feb 22; 330. PMID: 28215534
Single-Cell Genomic Characterization Reveals the Cellular Reprogramming of the Gastric Tumor Microenvironment.
Anuja Sathe, Susan M Grimes, +5 authors, Hanlee P Ji.
Clin Cancer Res, 2020 Feb 16; 26(11). PMID: 32060101    Free PMC article.
TCR Repertoire as a Novel Indicator for Immune Monitoring and Prognosis Assessment of Patients With Cervical Cancer.
Jin-Huan Cui, Kai-Rong Lin, +8 authors, Wei Luo.
Front Immunol, 2018 Dec 14; 9. PMID: 30524447    Free PMC article.
Targeting of the Cancer-Associated Fibroblast-T-Cell Axis in Solid Malignancies.
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J Clin Med, 2019 Nov 17; 8(11). PMID: 31731701    Free PMC article.
Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq.
Jun Chen, Shengbao Suo, +3 authors, Naihe Jing.
Nat Protoc, 2017 Feb 17; 12(3). PMID: 28207000
FDG PET/CT for assessing tumour response to immunotherapy : Report on the EANM symposium on immune modulation and recent review of the literature.
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Eur J Nucl Med Mol Imaging, 2018 Oct 07; 46(1). PMID: 30291373    Free PMC article.
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Immunogenic cell death in cancer and infectious disease.
Lorenzo Galluzzi, Aitziber Buqué, +2 authors, Guido Kroemer.
Nat Rev Immunol, 2016 Nov 01; 17(2). PMID: 27748397
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Early identification of antigen-specific immune responses in vivo by [18F]-labeled 3'-fluoro-3'-deoxy-thymidine ([18F]FLT) PET imaging.
Erik H J G Aarntzen, Mangala Srinivas, +13 authors, I Jolanda M de Vries.
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Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies.
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Blood, 2016 May 27; 128(4). PMID: 27226436    Free PMC article.
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Immunotype and immunohistologic characteristics of tumor-infiltrating immune cells are associated with clinical outcome in metastatic melanoma.
Gulsun Erdag, Jochen T Schaefer, +5 authors, Craig L Slingluff.
Cancer Res, 2012 Jan 24; 72(5). PMID: 22266112    Free PMC article.
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Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes.
Amanda M Ackermann, Zhiping Wang, +2 authors, Klaus H Kaestner.
Mol Metab, 2016 Mar 16; 5(3). PMID: 26977395    Free PMC article.
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SINCERITIES: inferring gene regulatory networks from time-stamped single cell transcriptional expression profiles.
Nan Papili Gao, S M Minhaz Ud-Dean, Olivier Gandrillon, Rudiyanto Gunawan.
Bioinformatics, 2017 Oct 03; 34(2). PMID: 28968704    Free PMC article.
Three-dimensional intact-tissue sequencing of single-cell transcriptional states.
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Science, 2018 Jun 23; 361(6400). PMID: 29930089    Free PMC article.
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Sequencing the peripheral blood B and T cell repertoire - Quantifying robustness and limitations.
Joel S Simon, Sergio Botero, Sanford M Simon.
J Immunol Methods, 2018 Oct 13; 463. PMID: 30312601    Free PMC article.
Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis.
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Science, 2019 Apr 06; 364(6435). PMID: 30948552
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Top 10 Challenges in Cancer Immunotherapy.
Priti S Hegde, Daniel S Chen.
Immunity, 2020 Jan 16; 52(1). PMID: 31940268
Immuno-positron emission tomography in cancer models.
Smitha Reddy, Matthew K Robinson.
Semin Nucl Med, 2010 Mar 31; 40(3). PMID: 20350627    Free PMC article.
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
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Cell Metab, 2016 Sep 20; 24(5). PMID: 27641098
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Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer.
A N Niemeijer, D Leung, +20 authors, A J de Langen.
Nat Commun, 2018 Nov 09; 9(1). PMID: 30405135    Free PMC article.
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W Denk, J H Strickler, W W Webb.
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The 2018 Nobel Prize in medicine goes to cancer immunotherapy (editorial for BMC cancer).
Zong Sheng Guo.
BMC Cancer, 2018 Nov 13; 18(1). PMID: 30415640    Free PMC article.
Immuno-PET Imaging of Engineered Human T Cells in Tumors.
Sabine Mall, Nahid Yusufi, +13 authors, Angela M Krackhardt.
Cancer Res, 2016 Jun 30; 76(14). PMID: 27354381
CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients.
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J Clin Invest, 2016 Apr 26; 126(6). PMID: 27111235    Free PMC article.
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Nanobodies derived from Camelids represent versatile biomolecules for biomedical applications.
Xinyu Yu, Qilan Xu, +6 authors, Jin Chen.
Biomater Sci, 2020 Jun 04; 8(13). PMID: 32490444
Mapping the physical network of cellular interactions.
Jean-Charles Boisset, Judith Vivié, +3 authors, Alexander van Oudenaarden.
Nat Methods, 2018 May 23; 15(7). PMID: 29786092
Intravital microscopy: visualizing immunity in context.
Cenk Sumen, Thorsten R Mempel, Irina B Mazo, Ulrich H von Andrian.
Immunity, 2004 Sep 11; 21(3). PMID: 15357943
Highly Cited. Review.
Granzyme B PET imaging of immune-mediated tumor killing as a tool for understanding immunotherapy response.
Thomas LaSalle, Emily E Austin, +4 authors, Umar Mahmood.
J Immunother Cancer, 2020 May 29; 8(1). PMID: 32461343    Free PMC article.
Hypoxia Studies with Pimonidazole in vivo.
Kristina Y Aguilera, Rolf A Brekken.
Bio Protoc, 2014 Oct 05; 4(19). PMID: 27453908    Free PMC article.
MIBI-TOF: A multiplexed imaging platform relates cellular phenotypes and tissue structure.
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Sci Adv, 2019 Oct 22; 5(10). PMID: 31633026    Free PMC article.
Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy.
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An Immune Atlas of Clear Cell Renal Cell Carcinoma.
Stéphane Chevrier, Jacob Harrison Levine, +14 authors, Bernd Bodenmiller.
Cell, 2017 May 06; 169(4). PMID: 28475899    Free PMC article.
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Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC).
Young Kwang Chae, Sangmin Chang, +6 authors, Marcelo Cruz.
Sci Rep, 2018 Feb 15; 8(1). PMID: 29440769    Free PMC article.
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Multiplexed ion beam imaging of human breast tumors.
Michael Angelo, Sean C Bendall, +9 authors, Garry P Nolan.
Nat Med, 2014 Mar 04; 20(4). PMID: 24584119    Free PMC article.
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Correlation between 18F-1-amino-3-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) uptake and expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter 1 (LAT1) in primary prostate cancer.
Irena Saarinen, Ivan Jambor, +9 authors, Heikki Minn.
EJNMMI Res, 2019 Jun 04; 9(1). PMID: 31152256    Free PMC article.
Aberrant type I and type III collagen gene expression in human breast cancer in vivo.
S Kauppila, F Stenbäck, +2 authors, L Risteli.
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The double edge sword of fibrosis in cancer.
Chelsea Chandler, Tianshi Liu, Ronald Buckanovich, Lan G Coffman.
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Comparison of trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid (anti-[18F]FACBC) accumulation in lymph node prostate cancer metastasis and lymphadenitis in rats.
Masaru Kanagawa, Yoshihiro Doi, +4 authors, Yoshifumi Shirakami.
Nucl Med Biol, 2014 May 13; 41(7). PMID: 24816330
Noninvasive monitoring of cancer therapy induced activated T cells using [18F]FB-IL-2 PET imaging.
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Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197364    Free PMC article.
SCENIC: single-cell regulatory network inference and clustering.
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Nat Methods, 2017 Oct 11; 14(11). PMID: 28991892    Free PMC article.
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Immunogenic and tolerogenic cell death.
Douglas R Green, Thomas Ferguson, Laurence Zitvogel, Guido Kroemer.
Nat Rev Immunol, 2009 Apr 15; 9(5). PMID: 19365408    Free PMC article.
Highly Cited. Review.
Recording the wild lives of immune cells.
Mikael J Pittet, Christopher S Garris, Sean P Arlauckas, Ralph Weissleder.
Sci Immunol, 2018 Sep 09; 3(27). PMID: 30194240    Free PMC article.
Spatial detection of fetal marker genes expressed at low level in adult human heart tissue.
Michaela Asp, Fredrik Salmén, +11 authors, Joakim Lundeberg.
Sci Rep, 2017 Oct 13; 7(1). PMID: 29021611    Free PMC article.
Understanding tumor ecosystems by single-cell sequencing: promises and limitations.
Xianwen Ren, Boxi Kang, Zemin Zhang.
Genome Biol, 2018 Dec 05; 19(1). PMID: 30509292    Free PMC article.
Dendritic-cell-based therapeutic cancer vaccines.
Karolina Palucka, Jacques Banchereau.
Immunity, 2013 Jul 31; 39(1). PMID: 23890062    Free PMC article.
Highly Cited. Review.
Trial Watch: Adoptively transferred cells for anticancer immunotherapy.
Carole Fournier, François Martin, +3 authors, Lionel Apetoh.
Oncoimmunology, 2017 Nov 18; 6(11). PMID: 29147628    Free PMC article.
Recent Advances in 19Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions.
Anne H Schmieder, Shelton D Caruthers, +2 authors, Gregory M Lanza.
Engineering (Beijing), 2016 Apr 26; 1(4). PMID: 27110430    Free PMC article.
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D J Chaplin, P L Olive, R E Durand.
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WNT/β-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers.
Jason J Luke, Riyue Bao, +2 authors, Thomas F Gajewski.
Clin Cancer Res, 2019 Jan 13; 25(10). PMID: 30635339    Free PMC article.
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QuPath: Open source software for digital pathology image analysis.
Peter Bankhead, Maurice B Loughrey, +10 authors, Peter W Hamilton.
Sci Rep, 2017 Dec 06; 7(1). PMID: 29203879    Free PMC article.
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A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling.
Junbin Qian, Siel Olbrecht, +21 authors, Diether Lambrechts.
Cell Res, 2020 Jun 21; 30(9). PMID: 32561858    Free PMC article.
The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer.
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Int J Mol Sci, 2019 May 19; 20(10). PMID: 31100853    Free PMC article.
Highly Cited. Review.
PI3Kγ is a molecular switch that controls immune suppression.
Megan M Kaneda, Karen S Messer, +20 authors, Judith A Varner.
Nature, 2016 Nov 01; 539(7629). PMID: 27642729    Free PMC article.
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Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma.
M A Varia, D P Calkins-Adams, +4 authors, J A Raleigh.
Gynecol Oncol, 1998 Nov 25; 71(2). PMID: 9826471
Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer.
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Sci China Life Sci, 2016 Mar 13; 59(5). PMID: 26968708
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Single-cell RNA-Seq unveils tumor microenvironment.
Hae-Ock Lee, Woong-Yang Park.
BMB Rep, 2017 May 26; 50(6). PMID: 28539161    Free PMC article.
Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk.
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Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123876    Free PMC article.
Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma.
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Sci Transl Med, 2017 Jan 20; 9(373). PMID: 28100832    Free PMC article.
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A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion.
Ivo J Huijbers, Marjan Iravani, +4 authors, Clare M Isacke.
PLoS One, 2010 Mar 27; 5(3). PMID: 20339555    Free PMC article.
Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy.
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Front Immunol, 2019 Mar 16; 10. PMID: 30873179    Free PMC article.
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ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide.
Jason D Buenrostro, Beijing Wu, Howard Y Chang, William J Greenleaf.
Curr Protoc Mol Biol, 2015 Jan 07; 109. PMID: 25559105    Free PMC article.
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Cell tracking using multimodal imaging.
Mangala Srinivas, Ignacio Melero, +2 authors, I Jolanda M de Vries.
Contrast Media Mol Imaging, 2014 Jan 01; 8(6). PMID: 24375899
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J Transl Med, 2019 Nov 07; 17(1). PMID: 31684954    Free PMC article.
Spatially Resolved Transcriptomics Enables Dissection of Genetic Heterogeneity in Stage III Cutaneous Malignant Melanoma.
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Cancer Res, 2018 Aug 30; 78(20). PMID: 30154148
Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors.
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LCM-Seq: A Method for Spatial Transcriptomic Profiling Using Laser Capture Microdissection Coupled with PolyA-Based RNA Sequencing.
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In Vivo PET Imaging of the Activated Immune Environment in a Small Animal Model of Inflammatory Arthritis.
Benjamin L Franc, Sam Goth, +6 authors, Henry VanBrocklin.
Mol Imaging, 2017 Jun 20; 16. PMID: 28625080    Free PMC article.
Basic Principles and Clinical Applications of Magnetic Resonance Spectroscopy in Neuroradiology.
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The Warburg Effect and the Hallmarks of Cancer.
Laurent Schwartz, Claudiu T Supuran, Khalid O Alfarouk.
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Highly Cited. Review.
Role of nelarabine in the treatment of T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma.
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Ther Clin Risk Manag, 2008 Jun 03; 3(6). PMID: 18516261    Free PMC article.
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Multiplexed Immunohistochemistry for Molecular and Immune Profiling in Lung Cancer-Just About Ready for Prime-Time?
Paul Hofman, Cécile Badoual, +8 authors, Marius Ilié.
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Novel Radiotracer for ImmunoPET Imaging of PD-1 Checkpoint Expression on Tumor Infiltrating Lymphocytes.
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Gregg L Semenza.
Cell, 2012 Feb 07; 148(3). PMID: 22304911    Free PMC article.
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IFNγ PET Imaging as a Predictive Tool for Monitoring Response to Tumor Immunotherapy.
Heather M Gibson, Brooke N McKnight, +6 authors, Nerissa T Viola-Villegas.
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Cytoplasmically retargeted HSV1-tk/GFP reporter gene mutants for optimization of noninvasive molecular-genetic imaging.
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Decreased reticuloendothelial system clearance and increased blood half-life and immune cell labeling for nano- and micron-sized superparamagnetic iron-oxide particles upon pre-treatment with Intralipid.
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Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.
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PET with 18F-FDG-labeled T lymphocytes for diagnosis of acute rat renal allograft rejection.
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Advances in PET Detection of the Antitumor T Cell Response.
M N McCracken, R Tavaré, O N Witte, A M Wu.
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Recent advances in superparamagnetic iron oxide nanoparticles for cellular imaging and targeted therapy research.
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Immunoscore encompassing CD3+ and CD8+ T cell densities in distant metastasis is a robust prognostic marker for advanced colorectal cancer.
Yoonjin Kwak, Jiwon Koh, +3 authors, Hye Seung Lee.
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Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy.
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Davide Bedognetti, Wouter Hendrickx, Francesco M Marincola, Lance D Miller.
Curr Opin Oncol, 2015 Sep 30; 27(6). PMID: 26418235
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Ping Guo, Quan Fang, +5 authors, Shi-Yuan Cheng.
Cancer Res, 2003 Aug 09; 63(15). PMID: 12907650
In Vivo Imaging Sheds Light on Immune Cell Migration and Function in Cancer.
Tommaso Torcellan, Jessica Stolp, Tatyana Chtanova.
Front Immunol, 2017 Apr 07; 8. PMID: 28382036    Free PMC article.
The Biodistribution of a CD3 and EpCAM Bispecific T-Cell Engager Is Driven by the CD3 Arm.
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J Nucl Med, 2020 Apr 15; 61(11). PMID: 32284393
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Sci Rep, 2019 Dec 22; 9(1). PMID: 31863083    Free PMC article.
Mer receptor tyrosine kinase negatively regulates lipoteichoic acid-induced inflammatory response via PI3K/Akt and SOCS3.
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Mol Immunol, 2016 Jul 16; 76. PMID: 27419619
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Genome Biol, 2018 Mar 11; 19(1). PMID: 29523163    Free PMC article.
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Nat Methods, 2019 May 16; 16(6). PMID: 31086342    Free PMC article.
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J Mol Med (Berl), 2014 Aug 15; 92(12). PMID: 25120128    Free PMC article.
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Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.
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Nat Med, 2018 Oct 10; 24(11). PMID: 30297909    Free PMC article.
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Therapeutic Targeting of Fibrotic Epithelial-Mesenchymal Transition-An Outstanding Challenge.
Attila Fintha, Ákos Gasparics, László Rosivall, Attila Sebe.
Front Pharmacol, 2019 May 07; 10. PMID: 31057405    Free PMC article.
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Nat Med, 2007 Dec 25; 14(1). PMID: 18157142
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Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy.
Philippe Bousso, Nirav R Bhakta, Richard S Lewis, Ellen Robey.
Science, 2002 Jun 08; 296(5574). PMID: 12052962
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Wolf Herman Fridman, Franck Pagès, Catherine Sautès-Fridman, Jérôme Galon.
Nat Rev Cancer, 2012 Mar 16; 12(4). PMID: 22419253
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Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas.
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Nat Biotechnol, 2020 Jan 15; 38(3). PMID: 31932730
Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance.
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Cell Metab, 2018 Jun 05; 28(1). PMID: 29861385
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Immunohistochemical study of type I collagen and type I pN-collagen in benign and malignant ovarian neoplasms.
G G Zhu, L Risteli, +3 authors, F Stenbäck.
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Nat Metab, 2020 Jul 23; 2(2). PMID: 32694689
Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing.
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Nat Med, 2018 Jun 27; 24(7). PMID: 29942094
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The Sodium/Iodide Symporter (NIS): Molecular Physiology and Preclinical and Clinical Applications.
Silvia Ravera, Andrea Reyna-Neyra, +2 authors, Nancy Carrasco.
Annu Rev Physiol, 2017 Feb 14; 79. PMID: 28192058    Free PMC article.
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Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity.
Emelie Berglund, Jonas Maaskola, +15 authors, Joakim Lundeberg.
Nat Commun, 2018 Jun 22; 9(1). PMID: 29925878    Free PMC article.
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Adenosine Blockage in Tumor Microenvironment and Improvement of Cancer Immunotherapy.
Samaneh Arab, Jamshid Hadjati.
Immune Netw, 2019 Sep 11; 19(4). PMID: 31501711    Free PMC article.
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Cell Stem Cell, 2013 Jan 08; 12(1). PMID: 23290136    Free PMC article.
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J Clin Invest, 2003 Mar 06; 111(5). PMID: 12618527    Free PMC article.
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma.
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CD8+ T cell states in human cancer: insights from single-cell analysis.
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Nat Rev Cancer, 2020 Feb 07; 20(4). PMID: 32024970    Free PMC article.
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Lee A Borthwick, Thomas A Wynn, Andrew J Fisher.
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Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma.
Sangeeta Goswami, Thomas Walle, +17 authors, Padmanee Sharma.
Nat Med, 2019 Dec 25; 26(1). PMID: 31873309    Free PMC article.
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Antioxid Redox Signal, 2007 Jun 19; 9(8). PMID: 17571959
Optical imaging of cellular immunotherapy against prostate cancer.
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Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop.
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Cancer Res, 2017 Sep 28; 77(22). PMID: 28947422    Free PMC article.
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Nat Commun, 2019 Aug 23; 10(1). PMID: 31434891    Free PMC article.
A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity.
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Nat Med, 2013 Apr 30; 19(6). PMID: 23624600
Impaired immune responses and antigen-specific memory CD4+ T cells in hemodialysis patients.
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Genomics and emerging biomarkers for immunotherapy of colorectal cancer.
Jakob Nikolas Kather, Niels Halama, Dirk Jaeger.
Semin Cancer Biol, 2018 Mar 05; 52(Pt 2). PMID: 29501787
Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function.
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The immune regulation in cancer by the amino acid metabolizing enzymes ARG and IDO.
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Curr Opin Pharmacol, 2017 May 30; 35. PMID: 28554057
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ImmunoPET Imaging of Murine CD4+ T Cells Using Anti-CD4 Cys-Diabody: Effects of Protein Dose on T Cell Function and Imaging.
Amanda C Freise, Kirstin A Zettlitz, +3 authors, Anna M Wu.
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Cell, 2017 Dec 05; 171(7). PMID: 29198524    Free PMC article.
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Resolving medulloblastoma cellular architecture by single-cell genomics.
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Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications.
J Löfblom, J Feldwisch, +3 authors, F Y Frejd.
FEBS Lett, 2010 Apr 15; 584(12). PMID: 20388508
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Single-cell RNA sequencing of immune cells in gastric cancer patients.
Kai Fu, Bingqing Hui, +10 authors, Ziyi Chen.
Aging (Albany NY), 2020 Feb 11; 12(3). PMID: 32039830    Free PMC article.
Laser Capture Microdissection and RNA-Seq Analysis: High Sensitivity Approaches to Explain Histopathological Heterogeneity in Human Glioblastoma FFPE Archived Tissues.
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Front Oncol, 2019 Jun 25; 9. PMID: 31231613    Free PMC article.
A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer.
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Cell, 2019 Apr 16; 177(5). PMID: 30982598    Free PMC article.
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First-in-Humans Imaging with 89Zr-Df-IAB22M2C Anti-CD8 Minibody in Patients with Solid Malignancies: Preliminary Pharmacokinetics, Biodistribution, and Lesion Targeting.
Neeta Pandit-Taskar, Michael A Postow, +18 authors, Jedd D Wolchok.
J Nucl Med, 2019 Oct 06; 61(4). PMID: 31586002    Free PMC article.
CD8+ T-Cell Density Imaging with 64Cu-Labeled Cys-Diabody Informs Immunotherapy Protocols.
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Clin Cancer Res, 2018 Jul 04; 24(20). PMID: 29967252    Free PMC article.
The Human Sodium Iodide Symporter as a Reporter Gene for Studying Middle East Respiratory Syndrome Coronavirus Pathogenesis.
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mSphere, 2018 Dec 14; 3(6). PMID: 30541777    Free PMC article.
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Proc Natl Acad Sci U S A, 2017 Sep 07; 114(38). PMID: 28874539    Free PMC article.
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Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma.
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Massis Krekorian, Gilbert O Fruhwirth, +4 authors, Erik H J G Aarntzen.
Theranostics, 2019 Oct 28; 9(25). PMID: 31656546    Free PMC article.
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Nature, 2014 Nov 28; 515(7528). PMID: 25428503
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The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.
Ryuhjin Ahn, Valérie Sabourin, +12 authors, Josie Ursini-Siegel.
Nat Commun, 2017 Mar 10; 8. PMID: 28276425    Free PMC article.
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.
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Brian A Rabinovich, Yang Ye, +6 authors, Patrick Hwu.
Proc Natl Acad Sci U S A, 2008 Sep 17; 105(38). PMID: 18794521    Free PMC article.
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Nat Med, 2018 Jul 11; 24(8). PMID: 29988129
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Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion-A New Role for the AXL Receptor Tyrosine Kinase.
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The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer.
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Front Immunol, 2019 Mar 23; 10. PMID: 30899263    Free PMC article.
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The immunologic constant of rejection classification refines the prognostic value of conventional prognostic signatures in breast cancer.
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Therapeutic targeting of naturally presented myeloperoxidase-derived HLA peptide ligands on myeloid leukemia cells by TCR-transgenic T cells.
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Imaging Granzyme B Activity Assesses Immune-Mediated Myocarditis.
Masanori Konishi, S Sibel Erdem, +3 authors, Peter Libby.
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Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images.
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A human liver cell atlas reveals heterogeneity and epithelial progenitors.
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Multiplexed ion beam imaging (MIBI) for characterization of the tumor microenvironment across tumor types.
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CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq.
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Intravital imaging of immune cells and their interactions with other cell types in the spinal cord: Experiments with multicolored moving cells.
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Massively parallel digital transcriptional profiling of single cells.
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