Review
. 2021 Feb; 11:604967.
doi: 10.3389/fimmu.2020.604967.

Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors

Violena Pietrobon 1 Alessandra Cesano 2 Francesco Marincola 1 Jakob Nikolas Kather 3 
Affiliations
  • PMID: 33584676
  •     387 References
  •     3 citations

Abstract

In recent years, cancer immunotherapy experienced remarkable developments and it is nowadays considered a promising therapeutic frontier against many types of cancer, especially hematological malignancies. However, in most types of solid tumors, immunotherapy efficacy is modest, partly because of the limited accessibility of lymphocytes to the tumor core. This immune exclusion is mediated by a variety of physical, functional and dynamic barriers, which play a role in shaping the immune infiltrate in the tumor microenvironment. At present there is no unified and integrated understanding about the role played by different postulated models of immune exclusion in human solid tumors. Systematically mapping immune landscapes or "topographies" in cancers of different histology is of pivotal importance to characterize spatial and temporal distribution of lymphocytes in the tumor microenvironment, providing insights into mechanisms of immune exclusion. Spatially mapping immune cells also provides quantitative information, which could be informative in clinical settings, for example for the discovery of new biomarkers that could guide the design of patient-specific immunotherapies. In this review, we aim to summarize current standard and next generation approaches to define Cancer Immune Topographies based on published studies and propose future perspectives.

Keywords: deep learning; imaging techniques; immune exclusion; immune topography; single-cell analysis; solid tumors.

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Quantifying tumor-infiltrating immune cells from transcriptomics data.
Francesca Finotello, Zlatko Trajanoski.
Cancer Immunol Immunother, 2018 Mar 16; 67(7). PMID: 29541787    Free PMC article.
Highly Cited. Review.
Noninvasive PET Imaging of T cells.
Weijun Wei, Dawei Jiang, +2 authors, Weibo Cai.
Trends Cancer, 2018 May 02; 4(5). PMID: 29709260    Free PMC article.
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Preclinical PET imaging of bispecific antibody ERY974 targeting CD3 and glypican 3 reveals that tumor uptake correlates to T cell infiltrate.
Stijn Jh Waaijer, Danique Giesen, +5 authors, Marjolijn N Lub-de Hooge.
J Immunother Cancer, 2020 Mar 29; 8(1). PMID: 32217763    Free PMC article.
TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors.
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Am J Transplant, 2004 Sep 16; 4(10). PMID: 15367216
Highly Cited.
Imaging activated T cells predicts response to cancer vaccines.
Israt S Alam, Aaron T Mayer, +7 authors, Sanjiv S Gambhir.
J Clin Invest, 2018 Mar 30; 128(6). PMID: 29596062    Free PMC article.
Highly Cited.
Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging.
Yury Goltsev, Nikolay Samusik, +5 authors, Garry P Nolan.
Cell, 2018 Aug 07; 174(4). PMID: 30078711    Free PMC article.
Highly Cited.
Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy.
Tina Cascone, Jodi A McKenzie, +34 authors, Weiyi Peng.
Cell Metab, 2018 Apr 10; 27(5). PMID: 29628419    Free PMC article.
Highly Cited.
Immunological mechanisms of the antitumor effects of supplemental oxygenation.
Stephen M Hatfield, Jorgen Kjaergaard, +15 authors, Michail V Sitkovsky.
Sci Transl Med, 2015 Mar 06; 7(277). PMID: 25739764    Free PMC article.
Highly Cited.
Targeting VEGF/VEGFR to Modulate Antitumor Immunity.
Ju Yang, Jing Yan, Baorui Liu.
Front Immunol, 2018 May 19; 9. PMID: 29774034    Free PMC article.
Highly Cited. Review.
Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives.
Paulo C Rodríguez, Augusto C Ochoa.
Immunol Rev, 2008 Mar 28; 222. PMID: 18364002    Free PMC article.
Highly Cited. Review.
Immune oncology, immune responsiveness and the theory of everything.
Tolga Turan, Deepti Kannan, +14 authors, Josue Samayoa.
J Immunother Cancer, 2018 Jun 07; 6(1). PMID: 29871670    Free PMC article.
Immunoregulatory activity of adenosine and its role in human cancer progression.
Sylvia Muller-Haegele, Laurent Muller, Theresa L Whiteside.
Expert Rev Clin Immunol, 2014 May 30; 10(7). PMID: 24871693
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Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade.
Mohammad Rashidian, Martin W LaFleur, +13 authors, Hidde L Ploegh.
Proc Natl Acad Sci U S A, 2019 Aug 04; 116(34). PMID: 31375632    Free PMC article.
High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes.
Mandeep Singh, Ghamdan Al-Eryani, +11 authors, Alexander Swarbrick.
Nat Commun, 2019 Jul 18; 10(1). PMID: 31311926    Free PMC article.
Adoptive immunotherapy of experimental autoimmune encephalomyelitis via T cell delivery of the IL-12 p40 subunit.
G L Costa, M R Sandora, +6 authors, J M Benson.
J Immunol, 2001 Aug 08; 167(4). PMID: 11490028
18F-FDG PET/CT for Monitoring of Ipilimumab Therapy in Patients with Metastatic Melanoma.
Kimiteru Ito, Rebecca Teng, +7 authors, Wolfgang A Weber.
J Nucl Med, 2018 Nov 11; 60(3). PMID: 30413661    Free PMC article.
Immunomodulatory Activity of VEGF in Cancer.
A Lapeyre-Prost, M Terme, +4 authors, J Taieb.
Int Rev Cell Mol Biol, 2017 Feb 22; 330. PMID: 28215534
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Single-Cell Genomic Characterization Reveals the Cellular Reprogramming of the Gastric Tumor Microenvironment.
Anuja Sathe, Susan M Grimes, +5 authors, Hanlee P Ji.
Clin Cancer Res, 2020 Feb 16; 26(11). PMID: 32060101    Free PMC article.
TCR Repertoire as a Novel Indicator for Immune Monitoring and Prognosis Assessment of Patients With Cervical Cancer.
Jin-Huan Cui, Kai-Rong Lin, +8 authors, Wei Luo.
Front Immunol, 2018 Dec 14; 9. PMID: 30524447    Free PMC article.
Targeting of the Cancer-Associated Fibroblast-T-Cell Axis in Solid Malignancies.
Tom J Harryvan, Els M E Verdegaal, +2 authors, Sjoerd H van der Burg.
J Clin Med, 2019 Nov 17; 8(11). PMID: 31731701    Free PMC article.
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Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq.
Jun Chen, Shengbao Suo, +3 authors, Naihe Jing.
Nat Protoc, 2017 Feb 17; 12(3). PMID: 28207000
FDG PET/CT for assessing tumour response to immunotherapy : Report on the EANM symposium on immune modulation and recent review of the literature.
Nicolas Aide, Rodney J Hicks, +3 authors, Egesta Lopci.
Eur J Nucl Med Mol Imaging, 2018 Oct 07; 46(1). PMID: 30291373    Free PMC article.
Highly Cited. Review.
Immunogenic cell death in cancer and infectious disease.
Lorenzo Galluzzi, Aitziber Buqué, +2 authors, Guido Kroemer.
Nat Rev Immunol, 2016 Nov 01; 17(2). PMID: 27748397
Highly Cited. Review.
Early identification of antigen-specific immune responses in vivo by [18F]-labeled 3'-fluoro-3'-deoxy-thymidine ([18F]FLT) PET imaging.
Erik H J G Aarntzen, Mangala Srinivas, +13 authors, I Jolanda M de Vries.
Proc Natl Acad Sci U S A, 2011 Oct 26; 108(45). PMID: 22025695    Free PMC article.
Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies.
Marianna Sabatino, Jinhui Hu, +12 authors, Luca Gattinoni.
Blood, 2016 May 27; 128(4). PMID: 27226436    Free PMC article.
Highly Cited.
Immunotype and immunohistologic characteristics of tumor-infiltrating immune cells are associated with clinical outcome in metastatic melanoma.
Gulsun Erdag, Jochen T Schaefer, +5 authors, Craig L Slingluff.
Cancer Res, 2012 Jan 24; 72(5). PMID: 22266112    Free PMC article.
Highly Cited.
Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes.
Amanda M Ackermann, Zhiping Wang, +2 authors, Klaus H Kaestner.
Mol Metab, 2016 Mar 16; 5(3). PMID: 26977395    Free PMC article.
Highly Cited.
SINCERITIES: inferring gene regulatory networks from time-stamped single cell transcriptional expression profiles.
Nan Papili Gao, S M Minhaz Ud-Dean, Olivier Gandrillon, Rudiyanto Gunawan.
Bioinformatics, 2017 Oct 03; 34(2). PMID: 28968704    Free PMC article.
Three-dimensional intact-tissue sequencing of single-cell transcriptional states.
Xiao Wang, William E Allen, +10 authors, Karl Deisseroth.
Science, 2018 Jun 23; 361(6400). PMID: 29930089    Free PMC article.
Highly Cited.
Sequencing the peripheral blood B and T cell repertoire - Quantifying robustness and limitations.
Joel S Simon, Sergio Botero, Sanford M Simon.
J Immunol Methods, 2018 Oct 13; 463. PMID: 30312601    Free PMC article.
Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis.
Silas Maniatis, Tarmo Äijö, +12 authors, Hemali Phatnani.
Science, 2019 Apr 06; 364(6435). PMID: 30948552
Highly Cited.
Top 10 Challenges in Cancer Immunotherapy.
Priti S Hegde, Daniel S Chen.
Immunity, 2020 Jan 16; 52(1). PMID: 31940268
Review.
Immuno-positron emission tomography in cancer models.
Smitha Reddy, Matthew K Robinson.
Semin Nucl Med, 2010 Mar 31; 40(3). PMID: 20350627    Free PMC article.
Review.
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Almut Brand, Katrin Singer, +36 authors, Marina Kreutz.
Cell Metab, 2016 Sep 20; 24(5). PMID: 27641098
Highly Cited.
Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer.
A N Niemeijer, D Leung, +20 authors, A J de Langen.
Nat Commun, 2018 Nov 09; 9(1). PMID: 30405135    Free PMC article.
Highly Cited.
Two-photon laser scanning fluorescence microscopy.
W Denk, J H Strickler, W W Webb.
Science, 1990 Apr 06; 248(4951). PMID: 2321027
Highly Cited.
The 2018 Nobel Prize in medicine goes to cancer immunotherapy (editorial for BMC cancer).
Zong Sheng Guo.
BMC Cancer, 2018 Nov 13; 18(1). PMID: 30415640    Free PMC article.
Immuno-PET Imaging of Engineered Human T Cells in Tumors.
Sabine Mall, Nahid Yusufi, +13 authors, Angela M Krackhardt.
Cancer Res, 2016 Jun 30; 76(14). PMID: 27354381
CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients.
Cameron J Turtle, Laïla-Aïcha Hanafi, +20 authors, David G Maloney.
J Clin Invest, 2016 Apr 26; 126(6). PMID: 27111235    Free PMC article.
Highly Cited.
Nanobodies derived from Camelids represent versatile biomolecules for biomedical applications.
Xinyu Yu, Qilan Xu, +6 authors, Jin Chen.
Biomater Sci, 2020 Jun 04; 8(13). PMID: 32490444
Review.
Mapping the physical network of cellular interactions.
Jean-Charles Boisset, Judith Vivié, +3 authors, Alexander van Oudenaarden.
Nat Methods, 2018 May 23; 15(7). PMID: 29786092
Intravital microscopy: visualizing immunity in context.
Cenk Sumen, Thorsten R Mempel, Irina B Mazo, Ulrich H von Andrian.
Immunity, 2004 Sep 11; 21(3). PMID: 15357943
Highly Cited. Review.
Granzyme B PET imaging of immune-mediated tumor killing as a tool for understanding immunotherapy response.
Thomas LaSalle, Emily E Austin, +4 authors, Umar Mahmood.
J Immunother Cancer, 2020 May 29; 8(1). PMID: 32461343    Free PMC article.
Hypoxia Studies with Pimonidazole in vivo.
Kristina Y Aguilera, Rolf A Brekken.
Bio Protoc, 2014 Oct 05; 4(19). PMID: 27453908    Free PMC article.
MIBI-TOF: A multiplexed imaging platform relates cellular phenotypes and tissue structure.
Leeat Keren, Marc Bosse, +16 authors, Michael Angelo.
Sci Adv, 2019 Oct 22; 5(10). PMID: 31633026    Free PMC article.
Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy.
Zhongping Yin, Ling Bai, +3 authors, Jiuwei Cui.
J Exp Clin Cancer Res, 2019 Sep 15; 38(1). PMID: 31519198    Free PMC article.
Review.
An Immune Atlas of Clear Cell Renal Cell Carcinoma.
Stéphane Chevrier, Jacob Harrison Levine, +14 authors, Bernd Bodenmiller.
Cell, 2017 May 06; 169(4). PMID: 28475899    Free PMC article.
Highly Cited.
Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC).
Young Kwang Chae, Sangmin Chang, +6 authors, Marcelo Cruz.
Sci Rep, 2018 Feb 15; 8(1). PMID: 29440769    Free PMC article.
Highly Cited.
Multiplexed ion beam imaging of human breast tumors.
Michael Angelo, Sean C Bendall, +9 authors, Garry P Nolan.
Nat Med, 2014 Mar 04; 20(4). PMID: 24584119    Free PMC article.
Highly Cited.
Correlation between 18F-1-amino-3-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) uptake and expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter 1 (LAT1) in primary prostate cancer.
Irena Saarinen, Ivan Jambor, +9 authors, Heikki Minn.
EJNMMI Res, 2019 Jun 04; 9(1). PMID: 31152256    Free PMC article.
Aberrant type I and type III collagen gene expression in human breast cancer in vivo.
S Kauppila, F Stenbäck, +2 authors, L Risteli.
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The double edge sword of fibrosis in cancer.
Chelsea Chandler, Tianshi Liu, Ronald Buckanovich, Lan G Coffman.
Transl Res, 2019 Mar 16; 209. PMID: 30871956    Free PMC article.
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Comparison of trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid (anti-[18F]FACBC) accumulation in lymph node prostate cancer metastasis and lymphadenitis in rats.
Masaru Kanagawa, Yoshihiro Doi, +4 authors, Yoshifumi Shirakami.
Nucl Med Biol, 2014 May 13; 41(7). PMID: 24816330
Noninvasive monitoring of cancer therapy induced activated T cells using [18F]FB-IL-2 PET imaging.
S V Hartimath, O Draghiciu, +5 authors, E F J de Vries.
Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197364    Free PMC article.
SCENIC: single-cell regulatory network inference and clustering.
Sara Aibar, Carmen Bravo González-Blas, +11 authors, Stein Aerts.
Nat Methods, 2017 Oct 11; 14(11). PMID: 28991892    Free PMC article.
Highly Cited.
Immunogenic and tolerogenic cell death.
Douglas R Green, Thomas Ferguson, Laurence Zitvogel, Guido Kroemer.
Nat Rev Immunol, 2009 Apr 15; 9(5). PMID: 19365408    Free PMC article.
Highly Cited. Review.
Recording the wild lives of immune cells.
Mikael J Pittet, Christopher S Garris, Sean P Arlauckas, Ralph Weissleder.
Sci Immunol, 2018 Sep 09; 3(27). PMID: 30194240    Free PMC article.
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Spatial detection of fetal marker genes expressed at low level in adult human heart tissue.
Michaela Asp, Fredrik Salmén, +11 authors, Joakim Lundeberg.
Sci Rep, 2017 Oct 13; 7(1). PMID: 29021611    Free PMC article.
Understanding tumor ecosystems by single-cell sequencing: promises and limitations.
Xianwen Ren, Boxi Kang, Zemin Zhang.
Genome Biol, 2018 Dec 05; 19(1). PMID: 30509292    Free PMC article.
Review.
Dendritic-cell-based therapeutic cancer vaccines.
Karolina Palucka, Jacques Banchereau.
Immunity, 2013 Jul 31; 39(1). PMID: 23890062    Free PMC article.
Highly Cited. Review.
Trial Watch: Adoptively transferred cells for anticancer immunotherapy.
Carole Fournier, François Martin, +3 authors, Lionel Apetoh.
Oncoimmunology, 2017 Nov 18; 6(11). PMID: 29147628    Free PMC article.
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Recent Advances in 19Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions.
Anne H Schmieder, Shelton D Caruthers, +2 authors, Gregory M Lanza.
Engineering (Beijing), 2016 Apr 26; 1(4). PMID: 27110430    Free PMC article.
Intermittent blood flow in a murine tumor: radiobiological effects.
D J Chaplin, P L Olive, R E Durand.
Cancer Res, 1987 Jan 15; 47(2). PMID: 3791244
Highly Cited.
WNT/β-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers.
Jason J Luke, Riyue Bao, +2 authors, Thomas F Gajewski.
Clin Cancer Res, 2019 Jan 13; 25(10). PMID: 30635339    Free PMC article.
Highly Cited.
QuPath: Open source software for digital pathology image analysis.
Peter Bankhead, Maurice B Loughrey, +10 authors, Peter W Hamilton.
Sci Rep, 2017 Dec 06; 7(1). PMID: 29203879    Free PMC article.
Highly Cited.
A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling.
Junbin Qian, Siel Olbrecht, +21 authors, Diether Lambrechts.
Cell Res, 2020 Jun 21; 30(9). PMID: 32561858    Free PMC article.
The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer.
Pascal Häfliger, Roch-Philippe Charles.
Int J Mol Sci, 2019 May 19; 20(10). PMID: 31100853    Free PMC article.
Highly Cited. Review.
PI3Kγ is a molecular switch that controls immune suppression.
Megan M Kaneda, Karen S Messer, +20 authors, Judith A Varner.
Nature, 2016 Nov 01; 539(7629). PMID: 27642729    Free PMC article.
Highly Cited.
Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma.
M A Varia, D P Calkins-Adams, +4 authors, J A Raleigh.
Gynecol Oncol, 1998 Nov 25; 71(2). PMID: 9826471
Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer.
Kaichao Feng, Yelei Guo, +4 authors, Weidong Han.
Sci China Life Sci, 2016 Mar 13; 59(5). PMID: 26968708
Highly Cited.
Single-cell RNA-Seq unveils tumor microenvironment.
Hae-Ock Lee, Woong-Yang Park.
BMB Rep, 2017 May 26; 50(6). PMID: 28539161    Free PMC article.
Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk.
Elise P Salerno, Davide Bedognetti, +9 authors, Craig L Slingluff.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123876    Free PMC article.
Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma.
Khun Visith Keu, Timothy H Witney, +14 authors, Sanjiv S Gambhir.
Sci Transl Med, 2017 Jan 20; 9(373). PMID: 28100832    Free PMC article.
Highly Cited.
A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion.
Ivo J Huijbers, Marjan Iravani, +4 authors, Clare M Isacke.
PLoS One, 2010 Mar 27; 5(3). PMID: 20339555    Free PMC article.
Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy.
Anna E Vilgelm, Ann Richmond.
Front Immunol, 2019 Mar 16; 10. PMID: 30873179    Free PMC article.
Highly Cited. Review.
ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide.
Jason D Buenrostro, Beijing Wu, Howard Y Chang, William J Greenleaf.
Curr Protoc Mol Biol, 2015 Jan 07; 109. PMID: 25559105    Free PMC article.
Highly Cited.
Cell tracking using multimodal imaging.
Mangala Srinivas, Ignacio Melero, +2 authors, I Jolanda M de Vries.
Contrast Media Mol Imaging, 2014 Jan 01; 8(6). PMID: 24375899
Review.
The tumor inflammation signature (TIS) is associated with anti-PD-1 treatment benefit in the CERTIM pan-cancer cohort.
Diane Damotte, Sarah Warren, +21 authors, Karen Leroy.
J Transl Med, 2019 Nov 07; 17(1). PMID: 31684954    Free PMC article.
Spatially Resolved Transcriptomics Enables Dissection of Genetic Heterogeneity in Stage III Cutaneous Malignant Melanoma.
Kim Thrane, Hanna Eriksson, +2 authors, Joakim Lundeberg.
Cancer Res, 2018 Aug 30; 78(20). PMID: 30154148
Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors.
Hélène Salmon, Katarzyna Franciszkiewicz, +5 authors, Emmanuel Donnadieu.
J Clin Invest, 2012 Feb 02; 122(3). PMID: 22293174    Free PMC article.
Highly Cited.
LCM-Seq: A Method for Spatial Transcriptomic Profiling Using Laser Capture Microdissection Coupled with PolyA-Based RNA Sequencing.
Susanne Nichterwitz, Julio Aguila Benitez, +2 authors, Eva Hedlund.
Methods Mol Biol, 2017 Nov 14; 1649. PMID: 29130192
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Linda Koch.
Nat Rev Genet, 2018 Aug 08; 19(10). PMID: 30082855
Rapid, low-input, low-bias construction of shotgun fragment libraries by high-density in vitro transposition.
Andrew Adey, Hilary G Morrison, +8 authors, Jay Shendure.
Genome Biol, 2010 Dec 15; 11(12). PMID: 21143862    Free PMC article.
Highly Cited.
In Vivo PET Imaging of the Activated Immune Environment in a Small Animal Model of Inflammatory Arthritis.
Benjamin L Franc, Sam Goth, +6 authors, Henry VanBrocklin.
Mol Imaging, 2017 Jun 20; 16. PMID: 28625080    Free PMC article.
Basic Principles and Clinical Applications of Magnetic Resonance Spectroscopy in Neuroradiology.
Stephan Ulmer, Martin Backens, Frank J Ahlhelm.
J Comput Assist Tomogr, 2015 Oct 21; 40(1). PMID: 26484954
Review.
The Warburg Effect and the Hallmarks of Cancer.
Laurent Schwartz, Claudiu T Supuran, Khalid O Alfarouk.
Anticancer Agents Med Chem, 2016 Nov 03; 17(2). PMID: 27804847
Review.
Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion.
Michael Platten, Wolfgang Wick, Benoît J Van den Eynde.
Cancer Res, 2012 Oct 24; 72(21). PMID: 23090118
Highly Cited. Review.
Role of nelarabine in the treatment of T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma.
Todd M Cooper.
Ther Clin Risk Manag, 2008 Jun 03; 3(6). PMID: 18516261    Free PMC article.
Comparative measurements of hypoxia in human brain tumors using needle electrodes and EF5 binding.
Sydney M Evans, Kevin D Judy, +11 authors, Cameron J Koch.
Cancer Res, 2004 Mar 05; 64(5). PMID: 14996753
Multiplexed Immunohistochemistry for Molecular and Immune Profiling in Lung Cancer-Just About Ready for Prime-Time?
Paul Hofman, Cécile Badoual, +8 authors, Marius Ilié.
Cancers (Basel), 2019 Mar 02; 11(3). PMID: 30818873    Free PMC article.
Review.
Novel Radiotracer for ImmunoPET Imaging of PD-1 Checkpoint Expression on Tumor Infiltrating Lymphocytes.
Arutselvan Natarajan, Aaron T Mayer, +3 authors, Sanjiv S Gambhir.
Bioconjug Chem, 2015 Aug 27; 26(10). PMID: 26307602
Hypoxia-inducible factors in physiology and medicine.
Gregg L Semenza.
Cell, 2012 Feb 07; 148(3). PMID: 22304911    Free PMC article.
Highly Cited. Review.
IFNγ PET Imaging as a Predictive Tool for Monitoring Response to Tumor Immunotherapy.
Heather M Gibson, Brooke N McKnight, +6 authors, Nerissa T Viola-Villegas.
Cancer Res, 2018 Aug 18; 78(19). PMID: 30115693    Free PMC article.
A genetic inference on cancer immune responsiveness.
Ena Wang, Lorenzo Uccellini, Francesco M Marincola.
Oncoimmunology, 2012 Jul 04; 1(4). PMID: 22754772    Free PMC article.
Single-cell spatial reconstruction reveals global division of labour in the mammalian liver.
Keren Bahar Halpern, Rom Shenhav, +13 authors, Shalev Itzkovitz.
Nature, 2017 Feb 07; 542(7641). PMID: 28166538    Free PMC article.
Highly Cited.
Cytoplasmically retargeted HSV1-tk/GFP reporter gene mutants for optimization of noninvasive molecular-genetic imaging.
Vladimir Ponomarev, Michael Doubrovin, +7 authors, Juri Gelovani Tjuvajev.
Neoplasia, 2003 Jul 19; 5(3). PMID: 12869307    Free PMC article.
Decreased reticuloendothelial system clearance and increased blood half-life and immune cell labeling for nano- and micron-sized superparamagnetic iron-oxide particles upon pre-treatment with Intralipid.
Li Liu, T Kevin Hitchens, +8 authors, Chien Ho.
Biochim Biophys Acta, 2013 Feb 12; 1830(6). PMID: 23396002    Free PMC article.
64Cu-DOTA-anti-CTLA-4 mAb enabled PET visualization of CTLA-4 on the T-cell infiltrating tumor tissues.
Kei Higashikawa, Katsuharu Yagi, +4 authors, Shuichi Enomoto.
PLoS One, 2014 Nov 05; 9(11). PMID: 25365349    Free PMC article.
Molecular imaging in tracking tumor-specific cytotoxic T lymphocytes (CTLs).
Zhiyi Liu, Zheng Li.
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Review.
In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer.
Michalina Janiszewska, Lin Liu, +12 authors, Kornelia Polyak.
Nat Genet, 2015 Aug 25; 47(10). PMID: 26301495    Free PMC article.
Highly Cited.
Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma.
Julien Calderaro, Florent Petitprez, +10 authors, Catherine Sautès-Fridman.
J Hepatol, 2018 Sep 15; 70(1). PMID: 30213589
The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment.
Lea Monteran, Neta Erez.
Front Immunol, 2019 Aug 21; 10. PMID: 31428105    Free PMC article.
Highly Cited. Review.
Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.
Bernhard Mlecnik, Gabriela Bindea, +29 authors, Jérôme Galon.
Immunity, 2016 Mar 18; 44(3). PMID: 26982367
Highly Cited.
PET with 18F-FDG-labeled T lymphocytes for diagnosis of acute rat renal allograft rejection.
Alexander Grabner, Dominik Kentrup, +7 authors, Stefan Reuter.
J Nucl Med, 2013 May 15; 54(7). PMID: 23670903
Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells.
Beatris Mastelic-Gavillet, Blanca Navarro Rodrigo, +23 authors, Selena Vigano.
J Immunother Cancer, 2019 Oct 12; 7(1). PMID: 31601268    Free PMC article.
Real-time imaging of HIF-1alpha stabilization and degradation.
Ekaterina Moroz, Sean Carlin, +4 authors, Inna Serganova.
PLoS One, 2009 Apr 07; 4(4). PMID: 19347037    Free PMC article.
Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position.
Jason D Buenrostro, Paul G Giresi, +2 authors, William J Greenleaf.
Nat Methods, 2013 Oct 08; 10(12). PMID: 24097267    Free PMC article.
Highly Cited.
Advances in PET Detection of the Antitumor T Cell Response.
M N McCracken, R Tavaré, O N Witte, A M Wu.
Adv Immunol, 2016 May 29; 131. PMID: 27235684    Free PMC article.
Review.
Single Cell T Cell Receptor Sequencing: Techniques and Future Challenges.
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Front Immunol, 2018 Aug 04; 9. PMID: 30072991    Free PMC article.
Review.
Two-photon imaging of the immune system.
Ivan L Dzhagalov, Heather J Melichar, +2 authors, Ellen A Robey.
Curr Protoc Cytom, 2012 Apr 04; Chapter 12. PMID: 22470153    Free PMC article.
Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma.
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Blood, 2011 Oct 11; 118(23). PMID: 21984804    Free PMC article.
Highly Cited.
Recent advances in superparamagnetic iron oxide nanoparticles for cellular imaging and targeted therapy research.
Yi-Xiang J Wang, Shouhu Xuan, Marc Port, Jean-Marc Idee.
Curr Pharm Des, 2013 Apr 30; 19(37). PMID: 23621536    Free PMC article.
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Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications.
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Int J Mol Sci, 2017 Oct 25; 18(10). PMID: 29064420    Free PMC article.
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Multiplexed detection of RNA using MERFISH and branched DNA amplification.
Chenglong Xia, Hazen P Babcock, Jeffrey R Moffitt, Xiaowei Zhuang.
Sci Rep, 2019 May 24; 9(1). PMID: 31118500    Free PMC article.
TGF-β and mesenchymal stromal cells in regenerative medicine, autoimmunity and cancer.
Virgínea de Araújo Farias, Ana Belén Carrillo-Gálvez, Francisco Martín, Per Anderson.
Cytokine Growth Factor Rev, 2018 Jun 30; 43. PMID: 29954665
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Hydrophilic fluorinated molecules for spectral 19F MRI.
Eric A Tanifum, Chandreshkumar Patel, +2 authors, Ananth V Annapragada.
Sci Rep, 2018 Feb 15; 8(1). PMID: 29440665    Free PMC article.
Massively parallel single-nucleus RNA-seq with DroNc-seq.
Naomi Habib, Inbal Avraham-Davidi, +11 authors, Aviv Regev.
Nat Methods, 2017 Aug 29; 14(10). PMID: 28846088    Free PMC article.
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Immunoscore encompassing CD3+ and CD8+ T cell densities in distant metastasis is a robust prognostic marker for advanced colorectal cancer.
Yoonjin Kwak, Jiwon Koh, +3 authors, Hye Seung Lee.
Oncotarget, 2016 Nov 12; 7(49). PMID: 27835889    Free PMC article.
Revisiting Immunotherapy: A Focus on Prostate Cancer.
Ha-Ram Cha, Joo Hyoung Lee, Selvarangan Ponnazhagan.
Cancer Res, 2020 Feb 19; 80(8). PMID: 32066566    Free PMC article.
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Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy.
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Development of AI-based pathology biomarkers in gastrointestinal and liver cancer.
Jakob N Kather, Julien Calderaro.
Nat Rev Gastroenterol Hepatol, 2020 Jul 06; 17(10). PMID: 32620817
Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort.
Laura Q M Chow, Robert Haddad, +19 authors, Tanguy Y Seiwert.
J Clin Oncol, 2016 Sep 21; 34(32). PMID: 27646946    Free PMC article.
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Multiplexed imaging of high-density libraries of RNAs with MERFISH and expansion microscopy.
Guiping Wang, Jeffrey R Moffitt, Xiaowei Zhuang.
Sci Rep, 2018 Mar 21; 8(1). PMID: 29555914    Free PMC article.
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Prognostic and predictive immune gene signatures in breast cancer.
Davide Bedognetti, Wouter Hendrickx, Francesco M Marincola, Lance D Miller.
Curr Opin Oncol, 2015 Sep 30; 27(6). PMID: 26418235
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Overexpression of vascular endothelial growth factor by MCF-7 breast cancer cells promotes estrogen-independent tumor growth in vivo.
Ping Guo, Quan Fang, +5 authors, Shi-Yuan Cheng.
Cancer Res, 2003 Aug 09; 63(15). PMID: 12907650
In Vivo Imaging Sheds Light on Immune Cell Migration and Function in Cancer.
Tommaso Torcellan, Jessica Stolp, Tatyana Chtanova.
Front Immunol, 2017 Apr 07; 8. PMID: 28382036    Free PMC article.
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The Biodistribution of a CD3 and EpCAM Bispecific T-Cell Engager Is Driven by the CD3 Arm.
Frans V Suurs, Grit Lorenczewski, +4 authors, Marjolijn N Lub-de Hooge.
J Nucl Med, 2020 Apr 15; 61(11). PMID: 32284393
Characterization of cancer omics and drug perturbations in panels of lung cancer cells.
Ayako Suzuki, Keiichi Onodera, +7 authors, Katsuya Tsuchihara.
Sci Rep, 2019 Dec 22; 9(1). PMID: 31863083    Free PMC article.
Mer receptor tyrosine kinase negatively regulates lipoteichoic acid-induced inflammatory response via PI3K/Akt and SOCS3.
Bing Zhang, Lei Fang, +3 authors, Rong-Yu Liu.
Mol Immunol, 2016 Jul 16; 76. PMID: 27419619
Quartz-Seq2: a high-throughput single-cell RNA-sequencing method that effectively uses limited sequence reads.
Yohei Sasagawa, Hiroki Danno, +5 authors, Itoshi Nikaido.
Genome Biol, 2018 Mar 11; 19(1). PMID: 29523163    Free PMC article.
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Feifei Wang, Hao Wan, +14 authors, Hongjie Dai.
Nat Methods, 2019 May 16; 16(6). PMID: 31086342    Free PMC article.
Prognostic significance of CXCL12 expression in patients with colorectal carcinoma.
Yuri Akishima-Fukasawa, Yukihiro Nakanishi, +3 authors, Setsuo Hirohashi.
Am J Clin Pathol, 2009 Jul 17; 132(2). PMID: 19605814
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection.
Stephen M Hatfield, Jorgen Kjaergaard, +15 authors, Michail Sitkovsky.
J Mol Med (Berl), 2014 Aug 15; 92(12). PMID: 25120128    Free PMC article.
[18F]FLT-PET in oncology: current status and opportunities.
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Eur J Nucl Med Mol Imaging, 2004 Nov 27; 31(12). PMID: 15565331
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James Russell, Sean Carlin, +3 authors, C Clifton Ling.
Int J Radiat Oncol Biol Phys, 2009 Mar 03; 73(4). PMID: 19251089    Free PMC article.
Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.
Rodabe N Amaria, Sangeetha M Reddy, +42 authors, Jennifer A Wargo.
Nat Med, 2018 Oct 10; 24(11). PMID: 30297909    Free PMC article.
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Therapeutic Targeting of Fibrotic Epithelial-Mesenchymal Transition-An Outstanding Challenge.
Attila Fintha, Ákos Gasparics, László Rosivall, Attila Sebe.
Front Pharmacol, 2019 May 07; 10. PMID: 31057405    Free PMC article.
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Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy.
Ronald J Buckanovich, Andrea Facciabene, +7 authors, George Coukos.
Nat Med, 2007 Dec 25; 14(1). PMID: 18157142
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Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy.
Philippe Bousso, Nirav R Bhakta, Richard S Lewis, Ellen Robey.
Science, 2002 Jun 08; 296(5574). PMID: 12052962
The immune contexture in human tumours: impact on clinical outcome.
Wolf Herman Fridman, Franck Pagès, Catherine Sautès-Fridman, Jérôme Galon.
Nat Rev Cancer, 2012 Mar 16; 12(4). PMID: 22419253
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Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas.
Reuben Moncada, Dalia Barkley, +6 authors, Itai Yanai.
Nat Biotechnol, 2020 Jan 15; 38(3). PMID: 31932730
Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance.
Hideki Iwamoto, Mitsuhiko Abe, +15 authors, Yihai Cao.
Cell Metab, 2018 Jun 05; 28(1). PMID: 29861385
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Immunohistochemical study of type I collagen and type I pN-collagen in benign and malignant ovarian neoplasms.
G G Zhu, L Risteli, +3 authors, F Stenbäck.
Cancer, 1995 Feb 15; 75(4). PMID: 7842402
We need to talk about the Warburg effect.
Ralph J DeBerardinis, Navdeep S Chandel.
Nat Metab, 2020 Jul 23; 2(2). PMID: 32694689
Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing.
Xinyi Guo, Yuanyuan Zhang, +16 authors, Zemin Zhang.
Nat Med, 2018 Jun 27; 24(7). PMID: 29942094
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The Sodium/Iodide Symporter (NIS): Molecular Physiology and Preclinical and Clinical Applications.
Silvia Ravera, Andrea Reyna-Neyra, +2 authors, Nancy Carrasco.
Annu Rev Physiol, 2017 Feb 14; 79. PMID: 28192058    Free PMC article.
Highly Cited. Review.
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity.
Emelie Berglund, Jonas Maaskola, +15 authors, Joakim Lundeberg.
Nat Commun, 2018 Jun 22; 9(1). PMID: 29925878    Free PMC article.
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Adenosine Blockage in Tumor Microenvironment and Improvement of Cancer Immunotherapy.
Samaneh Arab, Jamshid Hadjati.
Immune Netw, 2019 Sep 11; 19(4). PMID: 31501711    Free PMC article.
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Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.
Keiyo Takubo, Go Nagamatsu, +10 authors, Toshio Suda.
Cell Stem Cell, 2013 Jan 08; 12(1). PMID: 23290136    Free PMC article.
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Transcriptional output, cell-type densities, and normalization in spatial transcriptomics.
Manuel Saiselet, Joël Rodrigues-Vitória, +7 authors, Vincent Detours.
J Mol Cell Biol, 2020 Jun 24; 12(11). PMID: 32573704    Free PMC article.
Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor.
Li Yang, Noboru Yamagata, +8 authors, Richard M Breyer.
J Clin Invest, 2003 Mar 06; 111(5). PMID: 12618527    Free PMC article.
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma.
Junya Peng, Bao-Fa Sun, +20 authors, Wenming Wu.
Cell Res, 2019 Jul 06; 29(9). PMID: 31273297    Free PMC article.
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CD8+ T cell states in human cancer: insights from single-cell analysis.
Anne M van der Leun, Daniela S Thommen, Ton N Schumacher.
Nat Rev Cancer, 2020 Feb 07; 20(4). PMID: 32024970    Free PMC article.
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Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types.
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Science, 2014 Feb 18; 343(6172). PMID: 24531970    Free PMC article.
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Cytokine mediated tissue fibrosis.
Lee A Borthwick, Thomas A Wynn, Andrew J Fisher.
Biochim Biophys Acta, 2012 Oct 11; 1832(7). PMID: 23046809    Free PMC article.
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Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma.
Sangeeta Goswami, Thomas Walle, +17 authors, Padmanee Sharma.
Nat Med, 2019 Dec 25; 26(1). PMID: 31873309    Free PMC article.
The potential role of intrinsic hypoxia markers as prognostic variables in cancer.
Eui Jung Moon, David M Brizel, Jen-Tsan Ashley Chi, Mark W Dewhirst.
Antioxid Redox Signal, 2007 Jun 19; 9(8). PMID: 17571959
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Optical imaging of cellular immunotherapy against prostate cancer.
Sidhartha Tavri, Priyanka Jha, +10 authors, Heike E Daldrup-Link.
Mol Imaging, 2009 Apr 07; 8(1). PMID: 19344572
Cerenkov luminescence imaging: physics principles and potential applications in biomedical sciences.
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EJNMMI Phys, 2017 Mar 12; 4(1). PMID: 28283990    Free PMC article.
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Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop.
Davide Bedognetti, Michele Ceccarelli, +53 authors, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups.
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PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs.
Austin K Mattox, Jina Lee, +16 authors, Sara I Pai.
Cancer Res, 2017 Sep 28; 77(22). PMID: 28947422    Free PMC article.
Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes.
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Cancer Res, 2009 Feb 10; 69(4). PMID: 19201693    Free PMC article.
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Metabolic landscape of the tumor microenvironment at single cell resolution.
Zhengtao Xiao, Ziwei Dai, Jason W Locasale.
Nat Commun, 2019 Aug 23; 10(1). PMID: 31434891    Free PMC article.
A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity.
Dmitri Lodygin, Francesca Odoardi, +7 authors, Alexander Flügel.
Nat Med, 2013 Apr 30; 19(6). PMID: 23624600
Impaired immune responses and antigen-specific memory CD4+ T cells in hemodialysis patients.
Nicolle Helena Renier Litjens, Martin Huisman, Marinus van den Dorpel, Michiel Gerardus Henricus Betjes.
J Am Soc Nephrol, 2008 May 16; 19(8). PMID: 18480314    Free PMC article.
Integrated genome and transcriptome sequencing of the same cell.
Siddharth S Dey, Lennart Kester, +2 authors, Alexander van Oudenaarden.
Nat Biotechnol, 2015 Jan 20; 33(3). PMID: 25599178    Free PMC article.
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Genomics and emerging biomarkers for immunotherapy of colorectal cancer.
Jakob Nikolas Kather, Niels Halama, Dirk Jaeger.
Semin Cancer Biol, 2018 Mar 05; 52(Pt 2). PMID: 29501787
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Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function.
Selena Vigano, Dimitrios Alatzoglou, +4 authors, George Coukos.
Front Immunol, 2019 Jun 28; 10. PMID: 31244820    Free PMC article.
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The immune regulation in cancer by the amino acid metabolizing enzymes ARG and IDO.
Giada Mondanelli, Stefano Ugel, Ursula Grohmann, Vincenzo Bronte.
Curr Opin Pharmacol, 2017 May 30; 35. PMID: 28554057
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ImmunoPET Imaging of Murine CD4+ T Cells Using Anti-CD4 Cys-Diabody: Effects of Protein Dose on T Cell Function and Imaging.
Amanda C Freise, Kirstin A Zettlitz, +3 authors, Anna M Wu.
Mol Imaging Biol, 2016 Dec 15; 19(4). PMID: 27966069    Free PMC article.
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Methods Mol Biol, 2019 Apr 28; 1979. PMID: 31028636
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.
Sidharth V Puram, Itay Tirosh, +16 authors, Bradley E Bernstein.
Cell, 2017 Dec 05; 171(7). PMID: 29198524    Free PMC article.
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Resolving medulloblastoma cellular architecture by single-cell genomics.
Volker Hovestadt, Kyle S Smith, +48 authors, Paul A Northcott.
Nature, 2019 Jul 26; 572(7767). PMID: 31341285    Free PMC article.
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Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications.
J Löfblom, J Feldwisch, +3 authors, F Y Frejd.
FEBS Lett, 2010 Apr 15; 584(12). PMID: 20388508
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Single-cell RNA sequencing of immune cells in gastric cancer patients.
Kai Fu, Bingqing Hui, +10 authors, Ziyi Chen.
Aging (Albany NY), 2020 Feb 11; 12(3). PMID: 32039830    Free PMC article.
Laser Capture Microdissection and RNA-Seq Analysis: High Sensitivity Approaches to Explain Histopathological Heterogeneity in Human Glioblastoma FFPE Archived Tissues.
Prospero Civita, Sara Franceschi, +6 authors, Chiara Maria Mazzanti.
Front Oncol, 2019 Jun 25; 9. PMID: 31231613    Free PMC article.
A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer.
Johanna Wagner, Maria Anna Rapsomaniki, +15 authors, Bernd Bodenmiller.
Cell, 2019 Apr 16; 177(5). PMID: 30982598    Free PMC article.
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First-in-Humans Imaging with 89Zr-Df-IAB22M2C Anti-CD8 Minibody in Patients with Solid Malignancies: Preliminary Pharmacokinetics, Biodistribution, and Lesion Targeting.
Neeta Pandit-Taskar, Michael A Postow, +18 authors, Jedd D Wolchok.
J Nucl Med, 2019 Oct 06; 61(4). PMID: 31586002    Free PMC article.
CD8+ T-Cell Density Imaging with 64Cu-Labeled Cys-Diabody Informs Immunotherapy Protocols.
Jai Woong Seo, Richard Tavaré, +7 authors, Katherine W Ferrara.
Clin Cancer Res, 2018 Jul 04; 24(20). PMID: 29967252    Free PMC article.
The Human Sodium Iodide Symporter as a Reporter Gene for Studying Middle East Respiratory Syndrome Coronavirus Pathogenesis.
Svetlana Chefer, Jurgen Seidel, +21 authors, Reed F Johnson.
mSphere, 2018 Dec 14; 3(6). PMID: 30541777    Free PMC article.
Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection.
Jelena M Janjic, Mangala Srinivas, Deepak K K Kadayakkara, Eric T Ahrens.
J Am Chem Soc, 2008 Feb 13; 130(9). PMID: 18266363
Detection of immune responses after immunotherapy in glioblastoma using PET and MRI.
Joseph P Antonios, Horacio Soto, +11 authors, Robert M Prins.
Proc Natl Acad Sci U S A, 2017 Sep 07; 114(38). PMID: 28874539    Free PMC article.
Bioactivity and Safety of IL13Rα2-Redirected Chimeric Antigen Receptor CD8+ T Cells in Patients with Recurrent Glioblastoma.
Christine E Brown, Behnam Badie, +14 authors, Michael C Jensen.
Clin Cancer Res, 2015 Jun 11; 21(18). PMID: 26059190    Free PMC article.
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Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma.
Nabil Ahmed, Vita S Brawley, +23 authors, Stephen Gottschalk.
J Clin Oncol, 2015 Mar 25; 33(15). PMID: 25800760    Free PMC article.
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Imaging of T-cells and their responses during anti-cancer immunotherapy.
Massis Krekorian, Gilbert O Fruhwirth, +4 authors, Erik H J G Aarntzen.
Theranostics, 2019 Oct 28; 9(25). PMID: 31656546    Free PMC article.
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Nature, 2014 Nov 28; 515(7528). PMID: 25428503
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The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.
Ryuhjin Ahn, Valérie Sabourin, +12 authors, Josie Ursini-Siegel.
Nat Commun, 2017 Mar 10; 8. PMID: 28276425    Free PMC article.
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.
Itay Tirosh, Benjamin Izar, +34 authors, Levi A Garraway.
Science, 2016 Apr 29; 352(6282). PMID: 27124452    Free PMC article.
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Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer.
Brian A Rabinovich, Yang Ye, +6 authors, Patrick Hwu.
Proc Natl Acad Sci U S A, 2008 Sep 17; 105(38). PMID: 18794521    Free PMC article.
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Nat Med, 2018 Jul 11; 24(8). PMID: 29988129
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Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion-A New Role for the AXL Receptor Tyrosine Kinase.
Todd A Aguilera, Amato J Giaccia.
Clin Cancer Res, 2017 Mar 16; 23(12). PMID: 28289089    Free PMC article.
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The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer.
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Front Immunol, 2019 Mar 23; 10. PMID: 30899263    Free PMC article.
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Optimizing hypoxia detection and treatment strategies.
Cameron J Koch, Sydney M Evans.
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Jelena M Janjic, Eric T Ahrens.
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Low-dose eribulin mesylate exerts antitumor effects in gastric cancer by inhibiting fibrosis via the suppression of epithelial-mesenchymal transition and acts synergistically with 5-fluorouracil.
Toru Kurata, Sachio Fushida, +7 authors, Tetsuo Ohta.
Cancer Manag Res, 2018 Aug 28; 10. PMID: 30147370    Free PMC article.
Using MRI cell tracking to monitor immune cell recruitment in response to a peptide-based cancer vaccine.
Marie-Laurence Tremblay, Christa Davis, +6 authors, Kimberly D Brewer.
Magn Reson Med, 2017 Dec 02; 80(1). PMID: 29193231
Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations.
D J Pinato, R Ramachandran, +10 authors, T M Tan.
Br J Cancer, 2012 Dec 22; 108(2). PMID: 23257898    Free PMC article.
The changes of angiogenesis and immune cell infiltration in the intra- and peri-tumoral melanoma microenvironment.
Vladimir Zidlik, Svetlana Brychtova, +2 authors, Jana Dvorackova.
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The immunologic constant of rejection classification refines the prognostic value of conventional prognostic signatures in breast cancer.
François Bertucci, Pascal Finetti, +8 authors, Davide Bedognetti.
Br J Cancer, 2018 Oct 26; 119(11). PMID: 30353048    Free PMC article.
64Cu antibody-targeting of the T-cell receptor and subsequent internalization enables in vivo tracking of lymphocytes by PET.
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Proc Natl Acad Sci U S A, 2015 Jan 15; 112(4). PMID: 25587131    Free PMC article.
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J Biophotonics, 2018 May 18; 11(10). PMID: 29770603
Biodistribution and radiation dosimetry of the synthetic nonmetabolized amino acid analogue anti-18F-FACBC in humans.
Jonathon A Nye, David M Schuster, +3 authors, John R Votaw.
J Nucl Med, 2007 May 17; 48(6). PMID: 17504867
Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo.
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Proc Natl Acad Sci U S A, 2014 Jan 07; 111(3). PMID: 24390540    Free PMC article.
Molecular Imaging with Reporter Genes: Has Its Promise Been Delivered?
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The Paradox of Cancer Immune Exclusion: Immune Oncology Next Frontier.
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Cancer Treat Res, 2020 Mar 28; 180. PMID: 32215870    Free PMC article.
Eleven grand challenges in single-cell data science.
David Lähnemann, Johannes Köster, +48 authors, Alexander Schönhuth.
Genome Biol, 2020 Feb 09; 21(1). PMID: 32033589    Free PMC article.
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Therapeutic targeting of naturally presented myeloperoxidase-derived HLA peptide ligands on myeloid leukemia cells by TCR-transgenic T cells.
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Leukemia, 2014 Apr 17; 28(12). PMID: 24736212
Endothelin B receptor, a new target in cancer immune therapy.
Lana E Kandalaft, Andrea Facciabene, Ron J Buckanovich, George Coukos.
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Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing.
Chunhong Zheng, Liangtao Zheng, +13 authors, Zemin Zhang.
Cell, 2017 Jun 18; 169(7). PMID: 28622514
Highly Cited.
Imaging Granzyme B Activity Assesses Immune-Mediated Myocarditis.
Masanori Konishi, S Sibel Erdem, +3 authors, Peter Libby.
Circ Res, 2015 Jul 23; 117(6). PMID: 26199323    Free PMC article.
TGF-β signaling and epithelial-mesenchymal transition in cancer progression.
Yoko Katsuno, Samy Lamouille, Rik Derynck.
Curr Opin Oncol, 2012 Dec 01; 25(1). PMID: 23197193
Highly Cited. Review.
Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images.
Joel Saltz, Rajarsi Gupta, +14 authors, Vésteinn Thorsson.
Cell Rep, 2018 Apr 05; 23(1). PMID: 29617659    Free PMC article.
Highly Cited.
A human liver cell atlas reveals heterogeneity and epithelial progenitors.
Nadim Aizarani, Antonio Saviano, +6 authors, Dominic Grün.
Nature, 2019 Jul 12; 572(7768). PMID: 31292543    Free PMC article.
Highly Cited.
Multiplexed ion beam imaging (MIBI) for characterization of the tumor microenvironment across tumor types.
Jason Ptacek, Darren Locke, +8 authors, Jessica Finn.
Lab Invest, 2020 Mar 24; 100(8). PMID: 32203152
Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion.
Flávia Castro, Ana Patrícia Cardoso, +2 authors, Maria José Oliveira.
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Highly Cited. Review.
Cancer immunotherapy targeting the CD47/SIRPα axis.
Kipp Weiskopf.
Eur J Cancer, 2017 Mar 14; 76. PMID: 28286286
Highly Cited. Review.
Cancer: Imaging with antibodies.
Rosie Mestel.
Nature, 2017 Mar 31; 543(7647). PMID: 28358075
Metabolic activity by 18F-FDG-PET/CT is predictive of early response after nivolumab in previously treated NSCLC.
Kyoichi Kaira, Tetsuya Higuchi, +15 authors, Takayuki Asao.
Eur J Nucl Med Mol Imaging, 2017 Aug 23; 45(1). PMID: 28828507
Camelid Single-Domain Antibodies: Historical Perspective and Future Outlook.
Mehdi Arbabi-Ghahroudi.
Front Immunol, 2017 Dec 07; 8. PMID: 29209322    Free PMC article.
Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy.
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Highly Cited. Review.
CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq.
Tamar Hashimshony, Naftalie Senderovich, +10 authors, Itai Yanai.
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Highly Cited.
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Lorenzo Galluzzi, Ilio Vitale, +166 authors, Guido Kroemer.
Cell Death Differ, 2018 Jan 25; 25(3). PMID: 29362479    Free PMC article.
Highly Cited. Review.
Intravital imaging of immune cells and their interactions with other cell types in the spinal cord: Experiments with multicolored moving cells.
Teresa A Evans, Deborah S Barkauskas, Jerry Silver.
Exp Neurol, 2019 Jun 25; 320. PMID: 31234058
Review.
Dynamic imaging of T cell-dendritic cell interactions in lymph nodes.
Sabine Stoll, Jérôme Delon, Tilmann M Brotz, Ronald N Germain.
Science, 2002 Jun 08; 296(5574). PMID: 12052961
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Massively parallel digital transcriptional profiling of single cells.
Grace X Y Zheng, Jessica M Terry, +30 authors, Jason H Bielas.
Nat Commun, 2017 Jan 17; 8. PMID: 28091601    Free PMC article.
Highly Cited.
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.
G L Semenza.
Oncogene, 2009 Dec 01; 29(5). PMID: 19946328    Free PMC article.
Highly Cited. Review.
Magnetic resonance imaging.
Abi Berger.
BMJ, 2002 Jan 05; 324(7328). PMID: 11777806    Free PMC article.
Review.
Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells.
D I Gabrilovich, H L Chen, +5 authors, D P Carbone.
Nat Med, 1996 Oct 01; 2(10). PMID: 8837607
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Detection of immune-related adverse events by medical imaging in patients treated with anti-programmed cell death 1.
Ahmed Mekki, Laurent Dercle, +8 authors, Samy Ammari.
Eur J Cancer, 2018 Apr 27; 96. PMID: 29698933
CDSeq: A novel complete deconvolution method for dissecting heterogeneous samples using gene expression data.
Kai Kang, Qian Meng, +5 authors, Leping Li.
PLoS Comput Biol, 2019 Dec 04; 15(12). PMID: 31790389    Free PMC article.
18F-FAC PET Selectively Images Liver-Infiltrating CD4 and CD8 T Cells in a Mouse Model of Autoimmune Hepatitis.
Jessica R Salas, Bao Ying Chen, +4 authors, Peter M Clark.
J Nucl Med, 2018 Apr 28; 59(10). PMID: 29700125    Free PMC article.
Resistance to Checkpoint Inhibition in Cancer Immunotherapy.
Luisa Barrueto, Francheska Caminero, +3 authors, Rahul R Deshmukh.
Transl Oncol, 2020 Mar 03; 13(3). PMID: 32114384    Free PMC article.
Review.
Characteristics of tertiary lymphoid structures in primary cancers.
Jérémy Goc, Wolf-Herman Fridman, Catherine Sautès-Fridman, Marie-Caroline Dieu-Nosjean.
Oncoimmunology, 2014 Feb 06; 2(12). PMID: 24498556    Free PMC article.
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T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions.
Zeynep Sener, Fritjof H Cederkvist, +2 authors, Bjørn S Skålhegg.
PLoS One, 2016 Jul 29; 11(7). PMID: 27467144    Free PMC article.
Monitoring of technical variation in quantitative high-throughput datasets.
Martin Lauss, Ilhami Visne, +3 authors, Mattias Höglund.
Cancer Inform, 2013 Oct 05; 12. PMID: 24092958    Free PMC article.
In-depth Characterization of a TCR-specific Tracer for Sensitive Detection of Tumor-directed Transgenic T Cells by Immuno-PET.
Nahid Yusufi, Sabine Mall, +10 authors, Calogero D'Alessandria.
Theranostics, 2017 Jul 27; 7(9). PMID: 28744323    Free PMC article.
Interleukin-2: evaluation of routes of administration and current delivery systems in cancer therapy.
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J Pharm Sci, 2008 Nov 15; 98(7). PMID: 19009549
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Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.
G L Wang, G L Semenza.
J Biol Chem, 1993 Oct 15; 268(29). PMID: 8408001
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Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis.
Takahiro Tsujikawa, Sushil Kumar, +19 authors, Lisa M Coussens.
Cell Rep, 2017 Apr 06; 19(1). PMID: 28380359    Free PMC article.
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The Effectiveness of Checkpoint Inhibitor Combinations and Administration Timing Can Be Measured by Granzyme B PET Imaging.
Benjamin M Larimer, Emily Bloch, +4 authors, Umar Mahmood.
Clin Cancer Res, 2018 Oct 18; 25(4). PMID: 30327313    Free PMC article.
Imaging of CTLA4 blockade-induced cell replication with (18)F-FLT PET in patients with advanced melanoma treated with tremelimumab.
Antoni Ribas, Matthias R Benz, +7 authors, Johannes Czernin.
J Nucl Med, 2010 Feb 13; 51(3). PMID: 20150263
Hypoxia, glucose metabolism and the Warburg's effect.
Ramon Bartrons, Jaime Caro.
J Bioenerg Biomembr, 2007 Jul 31; 39(3). PMID: 17661163
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Quantitative CD3 PET Imaging Predicts Tumor Growth Response to Anti-CTLA-4 Therapy.
Benjamin M Larimer, Eric Wehrenberg-Klee, Alexander Caraballo, Umar Mahmood.
J Nucl Med, 2016 May 28; 57(10). PMID: 27230929    Free PMC article.
Epithelial-mesenchymal transition and plasticity in the developmental basis of cancer and fibrosis.
Raymond B Runyan, Pierre Savagner.
Dev Dyn, 2018 Feb 16; 247(3). PMID: 29446197
Engineering human tumor-specific cytotoxic T cells to function in a hypoxic environment.
Hongsung Kim, Guangyong Peng, +4 authors, Patricia Yotnda.
Mol Ther, 2008 Jan 30; 16(3). PMID: 18227840
CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes.
Mirjana Efremova, Miquel Vento-Tormo, Sarah A Teichmann, Roser Vento-Tormo.
Nat Protoc, 2020 Feb 28; 15(4). PMID: 32103204
Hypoxia-induced angiogenesis: good and evil.
Bryan L Krock, Nicolas Skuli, M Celeste Simon.
Genes Cancer, 2012 Aug 07; 2(12). PMID: 22866203    Free PMC article.
Highly Cited.
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity.
Stefani Spranger, Riyue Bao, Thomas F Gajewski.
Nature, 2015 May 15; 523(7559). PMID: 25970248
Highly Cited.
Spatial transcriptome profiling by MERFISH reveals subcellular RNA compartmentalization and cell cycle-dependent gene expression.
Chenglong Xia, Jean Fan, +2 authors, Xiaowei Zhuang.
Proc Natl Acad Sci U S A, 2019 Sep 11; 116(39). PMID: 31501331    Free PMC article.
Highly Cited.
Integrating Physical and Molecular Insights on Immune Cell Migration.
Hélène D Moreau, Matthieu Piel, Raphaël Voituriez, Ana-Maria Lennon-Duménil.
Trends Immunol, 2018 May 22; 39(8). PMID: 29779848
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Quartz-Seq: a highly reproducible and sensitive single-cell RNA sequencing method, reveals non-genetic gene-expression heterogeneity.
Yohei Sasagawa, Itoshi Nikaido, +4 authors, Hiroki R Ueda.
Genome Biol, 2013 Apr 19; 14(4). PMID: 23594475    Free PMC article.
Highly Cited.
Highly multiplexed immunofluorescence images and single-cell data of immune markers in tonsil and lung cancer.
Rumana Rashid, Giorgio Gaglia, +9 authors, Sandro Santagata.
Sci Data, 2019 Dec 19; 6(1). PMID: 31848351    Free PMC article.
Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal carcinoma.
Jin Zhao, Can Guo, +13 authors, Zhaoyang Zeng.
Cancer Lett, 2020 Feb 18; 477. PMID: 32061950
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells.
Luana Schito, Sergio Rey, +5 authors, Gregg L Semenza.
Proc Natl Acad Sci U S A, 2012 Sep 27; 109(40). PMID: 23012449    Free PMC article.
Granzyme B Is an Essential Mediator in CD8+ T Cell Killing of Theileria parva-Infected Cells.
Jie Yang, Alan Pemberton, W Ivan Morrison, Tim Connelley.
Infect Immun, 2018 Oct 17; 87(1). PMID: 30323022    Free PMC article.
Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma.
Sofia Lyford-Pike, Shiwen Peng, +12 authors, Sara I Pai.
Cancer Res, 2013 Jan 05; 73(6). PMID: 23288508    Free PMC article.
Highly Cited.
Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma.
Christian U Blank, Elisa A Rozeman, +21 authors, Ton N Schumacher.
Nat Med, 2018 Oct 10; 24(11). PMID: 30297911
Highly Cited.
Immune checkpoint blockade for unresectable or metastatic uveal melanoma: A systematic review.
Markus V Heppt, Theresa Steeb, +5 authors, Carola Berking.
Cancer Treat Rev, 2017 Sep 08; 60. PMID: 28881222
Systematic Review.
Targeting TNF-α to neoangiogenic vessels enhances lymphocyte infiltration in tumors and increases the therapeutic potential of immunotherapy.
Arianna Calcinotto, Matteo Grioni, +5 authors, Matteo Bellone.
J Immunol, 2012 Feb 11; 188(6). PMID: 22323546
Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput.
Todd M Gierahn, Marc H Wadsworth, +6 authors, Alex K Shalek.
Nat Methods, 2017 Feb 14; 14(4). PMID: 28192419    Free PMC article.
Highly Cited.
Immune checkpoint inhibitors in gastrointestinal malignancies: what can we learn from experience with other tumors?
Anand B Shah, Katelyn R Sommerer, Khaldoun Almhanna.
Transl Gastroenterol Hepatol, 2019 Nov 16; 4. PMID: 31728430    Free PMC article.
Review.
Multi-Omics Factor Analysis-a framework for unsupervised integration of multi-omics data sets.
Ricard Argelaguet, Britta Velten, +6 authors, Oliver Stegle.
Mol Syst Biol, 2018 Jun 22; 14(6). PMID: 29925568    Free PMC article.
Highly Cited.
Fluorine-19 MRI for detection and quantification of immune cell therapy for cancer.
Fanny Chapelin, Christian M Capitini, Eric T Ahrens.
J Immunother Cancer, 2018 Oct 12; 6(1). PMID: 30305175    Free PMC article.
Review.
Fibrotic focus in invasive ductal carcinoma of the breast: a histopathological prognostic parameter for tumor recurrence and tumor death within three years after the initial operation.
T Hasebe, H Tsuda, +2 authors, K Mukai.
Jpn J Cancer Res, 1997 Jun 01; 88(6). PMID: 9263537    Free PMC article.
Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice.
Matthias Mulazzani, Simon P Fräßle, +14 authors, Louisa von Baumgarten.
Proc Natl Acad Sci U S A, 2019 Nov 13; 116(48). PMID: 31712432    Free PMC article.
Defining the role of the tumor vasculature in antitumor immunity and immunotherapy.
Marco B Schaaf, Abhishek D Garg, Patrizia Agostinis.
Cell Death Dis, 2018 Jan 27; 9(2). PMID: 29371595    Free PMC article.
Highly Cited. Review.
TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer.
Laia Caja, Francesco Dituri, +4 authors, Isabel Fabregat.
Int J Mol Sci, 2018 Apr 28; 19(5). PMID: 29701666    Free PMC article.
Highly Cited. Review.
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.
Santiago Zelenay, Annemarthe G van der Veen, +9 authors, Caetano Reis e Sousa.
Cell, 2015 Sep 08; 162(6). PMID: 26343581    Free PMC article.
Highly Cited.
SingleCellSignalR: inference of intercellular networks from single-cell transcriptomics.
Simon Cabello-Aguilar, Mélissa Alame, +3 authors, Jacques Colinge.
Nucleic Acids Res, 2020 Mar 21; 48(10). PMID: 32196115    Free PMC article.
Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.
Christopher S Garris, Sean P Arlauckas, +20 authors, Mikael J Pittet.
Immunity, 2018 Dec 16; 49(6). PMID: 30552023    Free PMC article.
Highly Cited.
G&T-seq: parallel sequencing of single-cell genomes and transcriptomes.
Iain C Macaulay, Wilfried Haerty, +17 authors, Thierry Voet.
Nat Methods, 2015 Apr 29; 12(6). PMID: 25915121
Highly Cited.
A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer.
Stephen M Hatfield, Michail Sitkovsky.
Curr Opin Pharmacol, 2016 Jul 19; 29. PMID: 27429212    Free PMC article.
Review.
Signaling mechanisms of the epithelial-mesenchymal transition.
David M Gonzalez, Damian Medici.
Sci Signal, 2014 Sep 25; 7(344). PMID: 25249658    Free PMC article.
Highly Cited. Review.
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma.
Stephen M Ansell, Alexander M Lesokhin, +16 authors, Philippe Armand.
N Engl J Med, 2014 Dec 09; 372(4). PMID: 25482239    Free PMC article.
Highly Cited.
Nutrient and Metabolic Sensing in T Cell Responses.
Jun Wei, Jana Raynor, Thanh-Long M Nguyen, Hongbo Chi.
Front Immunol, 2017 Mar 25; 8. PMID: 28337199    Free PMC article.
Review.
Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.
Jeff Charles Kremer, Bethany Cheree Prudner, +16 authors, Brian Andrew Van Tine.
Cell Rep, 2017 Jan 26; 18(4). PMID: 28122247    Free PMC article.
Highly Cited.
In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors.
Moritz F Kircher, Jennifer R Allport, +4 authors, Ralph Weissleder.
Cancer Res, 2003 Oct 30; 63(20). PMID: 14583481
Spatial reconstruction of single-cell gene expression data.
Rahul Satija, Jeffrey A Farrell, +2 authors, Aviv Regev.
Nat Biotechnol, 2015 Apr 14; 33(5). PMID: 25867923    Free PMC article.
Highly Cited.
A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant.
John A Ronald, Byung-Su Kim, +23 authors, Sanjiv Sam Gambhir.
Cancer Res, 2017 Jun 03; 77(11). PMID: 28572504    Free PMC article.
The immunologic constant of rejection.
Ena Wang, Andrea Worschech, Francesco M Marincola.
Trends Immunol, 2008 May 07; 29(6). PMID: 18457994
Review.
Dive into Single, Seek Out Multiple: Probing Cancer Metastases via Single-Cell Sequencing and Imaging Techniques.
Shang Su, Xiaohong Li.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33802312    Free PMC article.
Review.
The Future of Cancer Diagnosis, Treatment and Surveillance: A Systemic Review on Immunotherapy and Immuno-PET Radiotracers.
Virginia Liberini, Riccardo Laudicella, +5 authors, Désirée Deandreis.
Molecules, 2021 May 01; 26(8). PMID: 33920423    Free PMC article.
Systematic Review.
NSCLC Biomarkers to Predict Response to Immunotherapy with Checkpoint Inhibitors (ICI): From the Cells to In Vivo Images.
Virginia Liberini, Annapaola Mariniello, +7 authors, Désirée Deandreis.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572771    Free PMC article.
Review.