. 2021 Feb; 48(8):2338-2350.
doi: 10.1007/s00259-021-05234-1.

Transpathology: molecular imaging-based pathology

Mei Tian 1 Xuexin He 2 Chentao Jin 3 Xiao He 3 Shuang Wu 3 Rui Zhou 3 Xiaohui Zhang 3 Kai Zhang 4 Weizhong Gu 5 Jing Wang 3 Hong Zhang 6 
  • PMID: 33585964
  •     115 References
  •     2 citations


Pathology is the medical specialty concerned with the study of the disease nature and causes, playing a key role in bridging basic researches and clinical medicine. In the course of development, pathology has significantly expanded our understanding of disease, and exerted enormous impact on the management of patients. However, challenges facing pathology, the inherent invasiveness of pathological practice and the persistent concerns on the sample representativeness, constitute its limitations. Molecular imaging is a noninvasive technique to visualize, characterize, and measure biological processes at the molecular level in living subjects. With the continuous development of equipment and probes, molecular imaging has enabled an increasingly precise evaluation of pathophysiological changes. A new pathophysiology visualization system based on molecular imaging is forming and shows the great potential to reform the pathological practice. Several improvements in "trans-," including trans-scale, transparency, and translation, would be driven by this new kind of pathological practice. Pathological changes could be evaluated in a trans-scale imaging mode; tissues could be transparentized to better present the underlying pathophysiological information; and the translational processes of basic research to the clinical practice would be better facilitated. Thus, transpathology would greatly facilitate in deciphering the pathophysiological events in a multiscale perspective, and supporting the precision medicine in the future.

Keywords: Digital pathology; Molecular imaging; Pathology; Transpathology.

Chemistry for Positron Emission Tomography: Recent Advances in 11 C-, 18 F-, 13 N-, and 15 O-Labeling Reactions.
Xiaoyun Deng, Jian Rong, +4 authors, Steven H Liang.
Angew Chem Int Ed Engl, 2018 Jul 29; 58(9). PMID: 30054961    Free PMC article.
Highly Cited. Review.
Artificial intelligence in cancer imaging: Clinical challenges and applications.
Wenya Linda Bi, Ahmed Hosny, +16 authors, Hugo J W L Aerts.
CA Cancer J Clin, 2019 Feb 06; 69(2). PMID: 30720861    Free PMC article.
Highly Cited. Review.
The Potential of Radiomic-Based Phenotyping in Precision Medicine: A Review.
Hugo J W L Aerts.
JAMA Oncol, 2016 Aug 20; 2(12). PMID: 27541161
Highly Cited. Review.
A nationwide survey of observer variation in the diagnosis of thin cutaneous malignant melanoma including the MIN terminology. CRC Melanoma Pathology Panel.
J Clin Pathol, 1997 Mar 01; 50(3). PMID: 9155669    Free PMC article.
Molecular imaging in patients with mood disorders: a review of PET findings.
Qiaozhen Chen, Weibo Liu, +2 authors, Mei Tian.
Eur J Nucl Med Mol Imaging, 2011 Apr 13; 38(7). PMID: 21484378
Molecular imaging of cancer with positron emission tomography.
Sanjiv Sam Gambhir.
Nat Rev Cancer, 2002 Sep 05; 2(9). PMID: 12209157
Highly Cited. Review.
The world's strongest MRI machines are pushing human imaging to new limits.
Anna Nowogrodzki.
Nature, 2018 Nov 02; 563(7729). PMID: 30382222
Evaluation of NGS and RT-PCR Methods for ALK Rearrangement in European NSCLC Patients: Results from the European Thoracic Oncology Platform Lungscape Project.
Igor Letovanec, Stephen Finn, +37 authors, European Thoracic Oncology Platform Lungscape Consortium.
J Thorac Oncol, 2017 Dec 02; 13(3). PMID: 29191776
Combined Injection of (18)F-Fluorodeoxyglucose and 3'-Deoxy-3'-[(18)F]fluorothymidine PET Achieves More Complete Identification of Viable Lung Cancer Cells in Mice and Patients than Individual Radiopharmaceutical: A Proof-of-Concept Study.
Xiao-Feng Li, Tao Huang, +6 authors, A Cahid Civelek.
Transl Oncol, 2014 Jan 28; 6(6). PMID: 24466381    Free PMC article.
The reliability of long-term storage of direct immunofluorescent staining slides at room temperature.
Emel Dikicioglu, Ibrahim Meteoglu, +2 authors, Furuzan Kacar.
J Cutan Pathol, 2003 Jul 16; 30(7). PMID: 12859740
Manganese-enhanced MRI of the myocardium.
Nick B Spath, Gerard Thompson, +3 authors, Scott I K Semple.
Heart, 2019 Jul 25; 105(22). PMID: 31337670    Free PMC article.
Spectroscopy imaging in intraoperative MR suite: tissue characterization and optimization of tumor resection.
Constantin Roder, Marco Skardelly, +6 authors, Sotirios Bisdas.
Int J Comput Assist Radiol Surg, 2013 Oct 22; 9(4). PMID: 24142628
Strategies of pain reduction during the bone marrow biopsy.
Nikolaj Hjortholm, Emil Jaddini, Kazimierz Hałaburda, Emilian Snarski.
Ann Hematol, 2012 Dec 12; 92(2). PMID: 23224244    Free PMC article.
Platform for quantitative multiscale imaging of tissue composition.
Michael A Pinkert, Zachary J Simmons, +6 authors, Kevin W Eliceiri.
Biomed Opt Express, 2020 Apr 29; 11(4). PMID: 32341858    Free PMC article.
Molecular pathology in real time.
Aleš Ryška.
Cancer Metastasis Rev, 2016 Mar 05; 35(1). PMID: 26931654
Development and in vivo imaging of a PET/MRI nanoprobe with enhanced NIR fluorescence by dye encapsulation.
Jun Sung Kim, Young-Hwa Kim, +11 authors, Dong Soo Lee.
Nanomedicine (Lond), 2011 Dec 20; 7(2). PMID: 22175235
Fibroblast Activation Protein (FAP) specific PET for advanced target volume delineation in glioblastoma.
Paul Windisch, Manuel Röhrich, +9 authors, Sebastian Adeberg.
Radiother Oncol, 2020 Jul 01; 150. PMID: 32598977
PET and MRI in cardiac imaging: from validation studies to integrated applications.
Stephan G Nekolla, Axel Martinez-Moeller, Antti Saraste.
Eur J Nucl Med Mol Imaging, 2008 Dec 24; 36 Suppl 1. PMID: 19104798
Twenty Years of Digital Pathology: An Overview of the Road Travelled, What is on the Horizon, and the Emergence of Vendor-Neutral Archives.
Liron Pantanowitz, Ashish Sharma, +3 authors, Joel Saltz.
J Pathol Inform, 2019 Jan 05; 9. PMID: 30607307    Free PMC article.
Needle tract pulmonary metastases.
G-L Chen, C-F Chian.
QJM, 2015 Apr 15; 108(10). PMID: 25870310
Tumor detection by nuclear magnetic resonance.
R Damadian.
Science, 1971 Mar 19; 171(3976). PMID: 5544870
Highly Cited.
Integrating pathology and radiology disciplines: an emerging opportunity?
James Sorace, Denise R Aberle, +3 authors, W Dean Wallace.
BMC Med, 2012 Sep 07; 10. PMID: 22950414    Free PMC article.
Imaging biomarker roadmap for cancer studies.
James P B O'Connor, Eric O Aboagye, +74 authors, John C Waterton.
Nat Rev Clin Oncol, 2016 Nov 03; 14(3). PMID: 27725679    Free PMC article.
Highly Cited. Review.
Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy.
Minbiao Ji, Daniel A Orringer, +14 authors, X Sunney Xie.
Sci Transl Med, 2013 Sep 06; 5(201). PMID: 24005159    Free PMC article.
Highly Cited.
Design, synthesis, and characterization of a dual modality positron emission tomography and fluorescence imaging agent for monoclonal antibody tumor-targeted imaging.
Heng Xu, Kwamena Baidoo, +4 authors, Martin W Brechbiel.
J Med Chem, 2007 Aug 30; 50(19). PMID: 17725340    Free PMC article.
Applications and challenges of digital pathology and whole slide imaging.
C Higgins.
Biotech Histochem, 2015 May 16; 90(5). PMID: 25978139
Glucose Metabolic Profile by Visual Assessment Combined with Statistical Parametric Mapping Analysis in Pediatric Patients with Epilepsy.
Yuankai Zhu, Jianhua Feng, +10 authors, Mei Tian.
J Nucl Med, 2017 Jan 21; 58(8). PMID: 28104740
Telepathology consultation for frozen section diagnosis in China.
Yingxin Huang, Yan Lei, +11 authors, Yongjian Deng.
Diagn Pathol, 2018 May 16; 13(1). PMID: 29759085    Free PMC article.
Digital pathology and artificial intelligence.
Muhammad Khalid Khan Niazi, Anil V Parwani, Metin N Gurcan.
Lancet Oncol, 2019 May 03; 20(5). PMID: 31044723
Highly Cited. Review.
Image Guided Focal Therapy for Magnetic Resonance Imaging Visible Prostate Cancer: Defining a 3-Dimensional Treatment Margin Based on Magnetic Resonance Imaging Histology Co-Registration Analysis.
Julien Le Nobin, Andrew B Rosenkrantz, +6 authors, Samir S Taneja.
J Urol, 2015 Feb 26; 194(2). PMID: 25711199    Free PMC article.
Targeting of microbubbles: contrast agents for ultrasound molecular imaging.
Shiying Wang, John A Hossack, Alexander L Klibanov.
J Drug Target, 2017 Dec 21; 26(5-6). PMID: 29258335    Free PMC article.
Optical molecular imaging for tumor detection and image-guided surgery.
Chensu Wang, Zhaohui Wang, +4 authors, Jinming Gao.
Biomaterials, 2017 Dec 16; 157. PMID: 29245052    Free PMC article.
Next-Generation Sequencing and Fluorescence in Situ Hybridization Have Comparable Performance Characteristics in the Analysis of Pancreaticobiliary Brushings for Malignancy.
Jonathan C Dudley, Zongli Zheng, +11 authors, A John Iafrate.
J Mol Diagn, 2015 Nov 26; 18(1). PMID: 26596524
Statistical analysis of spatial expression patterns for spatially resolved transcriptomic studies.
Shiquan Sun, Jiaqiang Zhu, Xiang Zhou.
Nat Methods, 2020 Jan 29; 17(2). PMID: 31988518    Free PMC article.
PET/SPECT imaging agents for neurodegenerative diseases.
Lin Zhu, Karl Ploessl, Hank F Kung.
Chem Soc Rev, 2014 Mar 29; 43(19). PMID: 24676152    Free PMC article.
Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma.
Markus W Löffler, Christopher Mohr, +29 authors, Hans-Georg Rammensee.
Genome Med, 2019 May 02; 11(1). PMID: 31039795    Free PMC article.
Highly Cited.
Small animal, positron emission tomography-magnetic resonance imaging system based on a clinical magnetic resonance imaging scanner: evaluation of basic imaging performance.
Raymond R Raylman, Patrick Ledden, +3 authors, Peter F Martone.
J Med Imaging (Bellingham), 2019 Mar 07; 5(3). PMID: 30840723    Free PMC article.
Integrative omics for health and disease.
Konrad J Karczewski, Michael P Snyder.
Nat Rev Genet, 2018 Feb 27; 19(5). PMID: 29479082    Free PMC article.
Highly Cited. Review.
Magnetic resonance spectroscopy to assess neuroinflammation and neuropathic pain.
Linda Chang, Sody M Munsaka, Stephanie Kraft-Terry, Thomas Ernst.
J Neuroimmune Pharmacol, 2013 May 15; 8(3). PMID: 23666436    Free PMC article.
Highly Cited. Review.
Clarifying Tissue Clearing.
Douglas S Richardson, Jeff W Lichtman.
Cell, 2015 Jul 18; 162(2). PMID: 26186186    Free PMC article.
Highly Cited. Review.
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Bruce D Cheson, Richard I Fisher, +19 authors, United Kingdom National Cancer Research Institute.
J Clin Oncol, 2014 Aug 13; 32(27). PMID: 25113753    Free PMC article.
Highly Cited.
Positron emission tomography reporter gene strategy for use in the central nervous system.
Tom Haywood, Corinne Beinat, +4 authors, Sanjiv Sam Gambhir.
Proc Natl Acad Sci U S A, 2019 May 28; 116(23). PMID: 31123153    Free PMC article.
μ-opioid receptor system mediates reward processing in humans.
Lauri Nummenmaa, Tiina Saanijoki, +4 authors, Kari Kalliokoski.
Nat Commun, 2018 Apr 18; 9(1). PMID: 29662095    Free PMC article.
The impact of standardized care pathway on reporting time for invasive melanoma - results from one pathology department in Sweden.
Margrét Agnarsdóttir, Helen Päären, Ismini Vassilaki.
Ups J Med Sci, 2019 Oct 30; 124(4). PMID: 31661366    Free PMC article.
Prostate cancer: local staging with endorectal surface coil MR imaging.
M D Schnall, Y Imai, +3 authors, H Y Kressel.
Radiology, 1991 Mar 01; 178(3). PMID: 1994421
PET: the merging of biology and imaging into molecular imaging.
M E Phelps.
J Nucl Med, 2000 Apr 18; 41(4). PMID: 10768568
X-ray-computed tomography contrast agents.
Hrvoje Lusic, Mark W Grinstaff.
Chem Rev, 2012 Dec 06; 113(3). PMID: 23210836    Free PMC article.
Highly Cited. Review.
Use of new imaging techniques to predict tumour response to therapy.
Vanessa N Harry, Scott I Semple, David E Parkin, Fiona J Gilbert.
Lancet Oncol, 2010 Feb 05; 11(1). PMID: 20129132
Computer-based System for the Virtual-Endoscopic Guidance of Bronchoscopy.
J P Helferty, A J Sherbondy, A P Kiraly, W E Higgins.
Comput Vis Image Underst, 2008 Nov 04; 108(1-2). PMID: 18978928    Free PMC article.
Potential of contrast agents to enhance in vivo confocal microscopy and optical coherence tomography in dermatology: A review.
Hans C Ring, Niels M Israelsen, +2 authors, Mette Mogensen.
J Biophotonics, 2019 Mar 10; 12(6). PMID: 30851078
Synthesis and preliminary evaluation of 18F-icotinib for EGFR-targeted PET imaging of lung cancer.
Xinmiao Lu, Cheng Wang, +3 authors, Lan Zhang.
Bioorg Med Chem, 2019 Jan 07; 27(3). PMID: 30611635
Digital pathology: Review of current opportunities and challenges for oral pathologists.
Yingci Liu, Liron Pantanowitz.
J Oral Pathol Med, 2019 Jan 09; 48(4). PMID: 30618114
Synthesis of 64Cu(II)-bis(dithiocarbamatebisphosphonate) and its conjugation with superparamagnetic iron oxide nanoparticles: in vivo evaluation as dual-modality PET-MRI agent.
Rafael Torres Martin de Rosales, Richard Tavaré, +6 authors, Philip J Blower.
Angew Chem Int Ed Engl, 2011 May 06; 50(24). PMID: 21544908    Free PMC article.
18F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy.
Yao Ding, Yuankai Zhu, +11 authors, Mei Tian.
Eur J Nucl Med Mol Imaging, 2018 Apr 20; 45(9). PMID: 29671038
Imaging of atherosclerosis, targeting LFA-1 on inflammatory cells with 111In-DANBIRT.
E J Meester, B J Krenning, +4 authors, K Van der Heiden.
J Nucl Cardiol, 2018 Mar 15; 26(5). PMID: 29536351    Free PMC article.
An entirely automated method to score DSS-induced colitis in mice by digital image analysis of pathology slides.
Cleopatra Kozlowski, Surinder Jeet, +5 authors, Lauri Diehl.
Dis Model Mech, 2013 Apr 13; 6(3). PMID: 23580198    Free PMC article.
Alteration of Monoamine Receptor Activity and Glucose Metabolism in Pediatric Patients with Anticonvulsant-Induced Cognitive Impairment.
Yuankai Zhu, Jianhua Feng, +11 authors, Mei Tian.
J Nucl Med, 2017 Mar 18; 58(9). PMID: 28302757
Artificial intelligence in digital pathology - new tools for diagnosis and precision oncology.
Kaustav Bera, Kurt A Schalper, +2 authors, Anant Madabhushi.
Nat Rev Clin Oncol, 2019 Aug 11; 16(11). PMID: 31399699    Free PMC article.
Highly Cited. Review.
Automated acquisition of explainable knowledge from unannotated histopathology images.
Yoichiro Yamamoto, Toyonori Tsuzuki, +16 authors, Go Kimura.
Nat Commun, 2019 Dec 20; 10(1). PMID: 31852890    Free PMC article.
Patient-specific model of brain deformation: application to medical image registration.
Adam Wittek, Karol Miller, Ron Kikinis, Simon K Warfield.
J Biomech, 2006 May 09; 40(4). PMID: 16678834
Suspicious liver nodule in chronic liver disease: Usefulness of a second biopsy.
V Cartier, A Crouan, +8 authors, CHIC group.
Diagn Interv Imaging, 2018 Mar 05; 99(7-8). PMID: 29501461
Multimodality imaging of naturally active melanin nanoparticles targeting somatostatin receptor subtype 2 in human small-cell lung cancer.
Lei Xia, Xiaoyi Guo, +6 authors, Zhi Yang.
Nanoscale, 2019 Jul 25; 11(30). PMID: 31334537
A comparative study of radiolabeled bombesin analogs for the PET imaging of prostate cancer.
Yang Liu, Xiang Hu, +7 authors, Zhen Cheng.
J Nucl Med, 2013 Nov 08; 54(12). PMID: 24198391    Free PMC article.
Biodistribution, cellular uptake and DNA-incorporation of the 2'-fluoro stabilized 5-iodo-2'-deoxyuridine analog 5-iodo-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil (FIAU).
A Morgenroth, S Deisenhofer, +4 authors, S N Reske.
Q J Nucl Med Mol Imaging, 2008 Apr 25; 52(3). PMID: 18432182
Intra-tumor genetic heterogeneity in Wilms tumor samples.
Bruna M de Sá Pereira, Rafaela Montalvão de Azevedo, +5 authors, Mariana Maschietto.
Rev Assoc Med Bras (1992), 2020 Jan 30; 65(12). PMID: 31994632
Feasibility and acceptance of simultaneous amyloid PET/MRI.
Lisa Schütz, Donald Lobsien, +16 authors, Henryk Barthel.
Eur J Nucl Med Mol Imaging, 2016 Jul 21; 43(12). PMID: 27435367
Going deeper than microscopy: the optical imaging frontier in biology.
Vasilis Ntziachristos.
Nat Methods, 2010 Aug 03; 7(8). PMID: 20676081
Highly Cited. Review.
Tissue clearing and its applications in neuroscience.
Hiroki R Ueda, Ali Ertürk, +4 authors, Philipp J Keller.
Nat Rev Neurosci, 2020 Jan 04; 21(2). PMID: 31896771    Free PMC article.
The increasing power of immunohistochemistry and immunocytochemistry.
P Brandtzaeg.
J Immunol Methods, 1998 Oct 06; 216(1-2). PMID: 9760215
PET/NIRF/MRI triple functional iron oxide nanoparticles.
Jin Xie, Kai Chen, +5 authors, Xiaoyuan Chen.
Biomaterials, 2010 Jan 23; 31(11). PMID: 20092887    Free PMC article.
Highly Cited.
Benchmarking deep learning models on large healthcare datasets.
Sanjay Purushotham, Chuizheng Meng, Zhengping Che, Yan Liu.
J Biomed Inform, 2018 Jun 08; 83. PMID: 29879470
A Coclinical Radiogenomic Validation Study: Conserved Magnetic Resonance Radiomic Appearance of Periostin-Expressing Glioblastoma in Patients and Xenograft Models.
Pascal O Zinn, Sanjay K Singh, +17 authors, Rivka R Colen.
Clin Cancer Res, 2018 Jul 29; 24(24). PMID: 30054278    Free PMC article.
Molecular imaging: exploring the next frontier.
R Weissleder.
Radiology, 1999 Sep 09; 212(3). PMID: 10478223
Inert coupling of IRDye800CW and zirconium-89 to monoclonal antibodies for single- or dual-mode fluorescence and PET imaging.
Ruth Cohen, Danielle J Vugts, +2 authors, Guus A M S van Dongen.
Nat Protoc, 2013 Apr 27; 8(5). PMID: 23619892
Revitalising an academic pathology department: lessons learnt.
Zu-Hua Gao, Edith Zorychta, +7 authors, Alan Spatz.
J Clin Pathol, 2018 Nov 24; 72(3). PMID: 30467243
Advantages and Limitations of Current Biomarker Research: From Experimental Research to Clinical Application.
Seung-Hyun Kim, Christel Weiß, +3 authors, Michael Behnes.
Curr Pharm Biotechnol, 2017 Jun 03; 18(6). PMID: 28571562
The use of virtual microscopy and a wiki in pathology education: Tracking student use, involvement, and response.
Zev Leifer.
J Pathol Inform, 2015 Jun 26; 6. PMID: 26110097    Free PMC article.
3D Digital Pathology for a Chemical-Functional Analysis of Glomeruli in Health and Pathology.
Hsiang-Hsin Chen, Tsung-Tse Lee, +2 authors, Cyril Petibois.
Anal Chem, 2018 Mar 06; 90(6). PMID: 29504770
Long-term utility and complication profile of open craniotomy for biopsy in patients with idiopathic encephalitis.
Kalil G Abdullah, Yin Li, +4 authors, Timothy H Lucas.
J Clin Neurosci, 2016 Dec 17; 37. PMID: 27979652
Is there still a role for SPECT-CT in oncology in the PET-CT era?
Rodney J Hicks, Michael S Hofman.
Nat Rev Clin Oncol, 2012 Nov 15; 9(12). PMID: 23149896
Brain ischemia: CT and MRI techniques in acute ischemic stroke.
Pedro Vilela, Howard A Rowley.
Eur J Radiol, 2017 Oct 22; 96. PMID: 29054448
An integrated diagnosis and therapeutic system using intra-operative 5-aminolevulinic-acid-induced fluorescence guided robotic laser ablation for precision neurosurgery.
Hongen Liao, Masafumi Noguchi, +4 authors, Ichiro Sakuma.
Med Image Anal, 2010 Dec 25; 16(3). PMID: 21183395
A phantom design for assessment of detectability in PET imaging.
Scott D Wollenweber, Adam M Alessio, Paul E Kinahan.
Med Phys, 2016 Sep 03; 43(9). PMID: 27587035
PET imaging reveals brain functional changes in internet gaming disorder.
Mei Tian, Qiaozhen Chen, +4 authors, Hong Zhang.
Eur J Nucl Med Mol Imaging, 2014 Apr 17; 41(7). PMID: 24737115
Single-scan dual-tracer FLT+FDG PET tumor characterization.
Dan J Kadrmas, Thomas C Rust, John M Hoffman.
Phys Med Biol, 2013 Jan 09; 58(3). PMID: 23296314    Free PMC article.
Trends in oncologic hybrid imaging.
Andreas G Wibmer, Hedvig Hricak, Gary A Ulaner, Wolfgang Weber.
Eur J Hybrid Imaging, 2018 May 22; 2(1). PMID: 29782605    Free PMC article.
Bimodal magnetic-fluorescent probes for bioimaging.
Dominik Jańczewski, Yan Zhang, +5 authors, Subramanian Tamil Selvan.
Microsc Res Tech, 2010 Aug 25; 74(7). PMID: 20734412
Instrumentation in molecular imaging.
R Glenn Wells.
J Nucl Cardiol, 2016 Apr 14; 23(6). PMID: 27072005
Hierarchical microimaging for multiscale analysis of large vascular networks.
Stefan Heinzer, Thomas Krucker, +5 authors, Ralph Müller.
Neuroimage, 2006 May 16; 32(2). PMID: 16697665
Total-Body PET: Maximizing Sensitivity to Create New Opportunities for Clinical Research and Patient Care.
Simon R Cherry, Terry Jones, +3 authors, Ramsey D Badawi.
J Nucl Med, 2017 Sep 25; 59(1). PMID: 28935835    Free PMC article.
Highly Cited. Review.
Rapid voxel classification methodology for interactive 3D medical image visualization.
Qi Zhang, Roy Eagleson, Terry M Peters.
Med Image Comput Comput Assist Interv, 2007 Nov 30; 10(Pt 2). PMID: 18044556
Complication rates of CT-guided transthoracic lung biopsy: meta-analysis.
W J Heerink, G H de Bock, +3 authors, M Oudkerk.
Eur Radiol, 2016 Apr 25; 27(1). PMID: 27108299    Free PMC article.
Highly Cited. Review.
Cardiac magnetic resonance imaging: the future is bright.
Karthik Seetharam, Stamatios Lerakis.
F1000Res, 2019 Sep 24; 8. PMID: 31543951    Free PMC article.
Image-guided interventions: technology review and clinical applications.
Kevin Cleary, Terry M Peters.
Annu Rev Biomed Eng, 2010 Apr 27; 12. PMID: 20415592
Deep optical imaging of tissue using the second and third near-infrared spectral windows.
Laura A Sordillo, Yang Pu, +2 authors, Robert R Alfano.
J Biomed Opt, 2014 May 09; 19(5). PMID: 24805808
(18)F-misonidazole PET imaging of hypoxia in micrometastases and macroscopic xenografts of human non-small cell lung cancer: a correlation with autoradiography and histological findings.
Tao Huang, A Cahid Civelek, +6 authors, Xiao-Feng Li.
Am J Nucl Med Mol Imaging, 2013 Mar 26; 3(2). PMID: 23526377    Free PMC article.
In Vivo Dynamic Metabolic Changes After Transplantation of Induced Pluripotent Stem Cells for Ischemic Injury.
Shuang Wu, Yuankai Zhu, +15 authors, Mei Tian.
J Nucl Med, 2016 Aug 27; 57(12). PMID: 27561881
Multiscale and multi-modality visualization of angiogenesis in a human breast cancer model.
Jana Cebulla, Eugene Kim, +2 authors, Arvind P Pathak.
Angiogenesis, 2014 Apr 11; 17(3). PMID: 24719185    Free PMC article.
A brief history of pathology: Preface to a forthcoming series that highlights milestones in the evolution of pathology as a discipline.
Jan G van den Tweel, Clive R Taylor.
Virchows Arch, 2010 May 26; 457(1). PMID: 20499087    Free PMC article.
Systematic imaging in medicine: a comprehensive review.
Kai Zhang, Yujie Sun, +11 authors, Hong Zhang.
Eur J Nucl Med Mol Imaging, 2020 Nov 20; 48(6). PMID: 33210241
Fast image mapping of endoscopic image mosaics with three-dimensional ultrasound image for intrauterine fetal surgery.
Hongen Liao, Masayoshi Tsuzuki, +3 authors, Ichiro Sakuma.
Minim Invasive Ther Allied Technol, 2009 Nov 26; 18(6). PMID: 19929295
A Bridge Not Too Far: Linking Disciplines Through Molecular Imaging Probes.
John F Valliant.
J Nucl Med Technol, 2016 Sep 08; 44(3). PMID: 27601414
Optical coherence tomography angiography.
Richard F Spaide, James G Fujimoto, +2 authors, Giovanni Staurenghi.
Prog Retin Eye Res, 2017 Dec 13; 64. PMID: 29229445    Free PMC article.
Highly Cited. Review.
Neural correlates of the popular music phenomenon: evidence from functional MRI and PET imaging.
Qiaozhen Chen, Ying Zhang, +8 authors, Mei Tian.
Eur J Nucl Med Mol Imaging, 2017 Jan 14; 44(6). PMID: 28083689
Autoradiography techniques and quantification of drug distribution.
Eric G Solon.
Cell Tissue Res, 2015 Jan 22; 360(1). PMID: 25604842
Intravascular catheter navigation using path planning and virtual visual feedback for oral cancer treatment.
Junchen Wang, Takashi Ohya, +4 authors, Toshinori Iwai.
Int J Med Robot, 2011 May 04; 7(2). PMID: 21538770
Update on time-of-flight PET imaging.
Suleman Surti.
J Nucl Med, 2014 Dec 20; 56(1). PMID: 25525181    Free PMC article.
68Ga-PSMA PET/CT in the evaluation of bone metastases in prostate cancer.
Christos Sachpekidis, P Bäumer, +5 authors, A Dimitrakopoulou-Strauss.
Eur J Nucl Med Mol Imaging, 2018 Jan 25; 45(6). PMID: 29362859
The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology.
John K C Chan.
Int J Surg Pathol, 2014 Jan 11; 22(1). PMID: 24406626
(18)F-fluorodeoxyglucose uptake and tumor hypoxia: revisit (18)f-fluorodeoxyglucose in oncology application.
Xiao-Feng Li, Yang Du, +2 authors, A Cahid Civelek.
Transl Oncol, 2014 Apr 05; 7(2). PMID: 24699008    Free PMC article.
Molecular imaging biomarkers for immune checkpoint inhibitor therapy.
Pim P van de Donk, Laura Kist de Ruijter, +6 authors, Elisabeth Ge de Vries.
Theranostics, 2020 Feb 12; 10(4). PMID: 32042331    Free PMC article.
Spatial Concordance of Tumor Proliferation and Accelerated Repopulation from Pathologic Images to 3'-[18F]Fluoro-3'-Deoxythymidine PET Images: a Basic Study Guided for PET-Based Radiotherapy Dose Painting.
Chengming Li, Xiaoli Zhang, +5 authors, Xue Meng.
Mol Imaging Biol, 2018 Nov 09; 21(4). PMID: 30406513
PET-based molecular imaging in neuroscience.
A H Jacobs, H Li, +16 authors, W D Heiss.
Eur J Nucl Med Mol Imaging, 2003 May 24; 30(7). PMID: 12764552
Intrinsically radioactive [64Cu]CuInS/ZnS quantum dots for PET and optical imaging: improved radiochemical stability and controllable Cerenkov luminescence.
Weisheng Guo, Xiaolian Sun, +7 authors, Xiaoyuan Chen.
ACS Nano, 2014 Dec 31; 9(1). PMID: 25549258    Free PMC article.
Overview of Telepathology.
Navid Farahani, Liron Pantanowitz.
Surg Pathol Clin, 2015 Jun 13; 8(2). PMID: 26065796
Positron emission tomography in the COVID-19 pandemic era.
Chentao Jin, Xiaoyun Luo, +7 authors, Mei Tian.
Eur J Nucl Med Mol Imaging, 2021 May 21;. PMID: 34013405    Free PMC article.
Structural, Functional, and Molecular Imaging of Autism Spectrum Disorder.
Xiaoyi Li, Kai Zhang, +6 authors, Hong Zhang.
Neurosci Bull, 2021 Mar 30; 37(7). PMID: 33779890    Free PMC article.