Journal Article
. 2021 May; 19(5):541-565.
doi: 10.6004/jnccn.2021.0022.

Hepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology

Al B Benson 1 Michael I D'Angelica 2 Daniel E Abbott 3 Daniel A Anaya 4 Robert Anders 5 Chandrakanth Are 6 Melinda Bachini 7 Mitesh Borad 8 Daniel Brown 9 Adam Burgoyne 10 Prabhleen Chahal 11 Daniel T Chang 12 Jordan Cloyd 13 Anne M Covey 2 Evan S Glazer 14 Lipika Goyal 15 William G Hawkins 16 Renuka Iyer 17 Rojymon Jacob 18 R Kate Kelley 19 Robin Kim 20 Matthew Levine 21 Manisha Palta 22 James O Park 23 Steven Raman 24 Sanjay Reddy 25 Vaibhav Sahai 26 Tracey Schefter 27 Gagandeep Singh 28 Stacey Stein 29 Jean-Nicolas Vauthey 30 Alan P Venook 19 Adam Yopp 31 Nicole R McMillian 32 Cindy Hochstetler 32 Susan D Darlow 32 
  • PMID: 34030131
  •     36 citations


The NCCN Guidelines for Hepatobiliary Cancers focus on the screening, diagnosis, staging, treatment, and management of hepatocellular carcinoma (HCC), gallbladder cancer, and cancer of the bile ducts (intrahepatic and extrahepatic cholangiocarcinoma). Due to the multiple modalities that can be used to treat the disease and the complications that can arise from comorbid liver dysfunction, a multidisciplinary evaluation is essential for determining an optimal treatment strategy. A multidisciplinary team should include hepatologists, diagnostic radiologists, interventional radiologists, surgeons, medical oncologists, and pathologists with hepatobiliary cancer expertise. In addition to surgery, transplant, and intra-arterial therapies, there have been great advances in the systemic treatment of HCC. Until recently, sorafenib was the only systemic therapy option for patients with advanced HCC. In 2020, the combination of atezolizumab and bevacizumab became the first regimen to show superior survival to sorafenib, gaining it FDA approval as a new frontline standard regimen for unresectable or metastatic HCC. This article discusses the NCCN Guidelines recommendations for HCC.

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