Review
. 2021 Jul; 22(13):.
doi: 10.3390/ijms22136741.

MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It

Elena Shklovskaya 1 Helen Rizos 1 
Affiliations
  • PMID: 34201655
  •     347 References
  •     2 citations

Abstract

It is now well accepted that the immune system can control cancer growth. However, tumors escape immune-mediated control through multiple mechanisms and the downregulation or loss of major histocompatibility class (MHC)-I molecules is a common immune escape mechanism in many cancers. MHC-I molecules present antigenic peptides to cytotoxic T cells, and MHC-I loss can render tumor cells invisible to the immune system. In this review, we examine the dysregulation of MHC-I expression in cancer, explore the nature of MHC-I-bound antigenic peptides recognized by immune cells, and discuss therapeutic strategies that can be used to overcome MHC-I deficiency in solid tumors, with a focus on the role of natural killer (NK) cells and CD4 T cells.

Keywords: MHC-I; NK cells; T-cell subsets; immune checkpoint blockade; immunotherapy; major histocompatibility complex (MHC); tumor antigen presentation; tumor antigens.

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Nature, 2020 Jan 17; 577(7791). PMID: 31942077
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The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy.
Daniel Zingg, Natalia Arenas-Ramirez, +5 authors, Onur Boyman.
Cell Rep, 2017 Jul 27; 20(4). PMID: 28746871
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Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses.
Katrina Soderquest, Thierry Walzer, +5 authors, Alfonso Martín-Fontecha.
J Immunol, 2011 Feb 11; 186(6). PMID: 21307295
The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.
Daniel Zingg, Julien Debbache, +15 authors, Lukas Sommer.
Nat Commun, 2015 Jan 23; 6. PMID: 25609585
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Serum Immunoregulatory Proteins as Predictors of Overall Survival of Metastatic Melanoma Patients Treated with Ipilimumab.
Yoshinobu Koguchi, Helena M Hoen, +8 authors, Keith S Bahjat.
Cancer Res, 2015 Dec 03; 75(23). PMID: 26627641
High-Throughput Stability Screening of Neoantigen/HLA Complexes Improves Immunogenicity Predictions.
Dylan T Blaha, Scott D Anderson, +4 authors, David M Kranz.
Cancer Immunol Res, 2018 Nov 15; 7(1). PMID: 30425106    Free PMC article.
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.
Dung T Le, Jennifer N Uram, +32 authors, Luis A Diaz.
N Engl J Med, 2015 Jun 02; 372(26). PMID: 26028255    Free PMC article.
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Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma.
Akash M Mehta, Ekaterina S Jordanova, +2 authors, Gert-Jan Fleuren.
Cancer Immunol Immunother, 2007 Jul 12; 57(2). PMID: 17622526    Free PMC article.
Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma.
David Liu, Bastian Schilling, +33 authors, Dirk Schadendorf.
Nat Med, 2019 Dec 04; 25(12). PMID: 31792460    Free PMC article.
Highly Cited.
CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation.
Harry Z Qui, Adam T Hagymasi, +8 authors, Adam J Adler.
J Immunol, 2011 Sep 02; 187(7). PMID: 21880986    Free PMC article.
TNF-α-induced Tim-3 expression marks the dysfunction of infiltrating natural killer cells in human esophageal cancer.
Yujia Zheng, Yu Li, +6 authors, Lan Huang.
J Transl Med, 2019 May 22; 17(1). PMID: 31109341    Free PMC article.
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Victor Appay, John J Zaunders, +10 authors, Anthony D Kelleher.
J Immunol, 2002 May 23; 168(11). PMID: 12023402
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Epigenetic modulation in cancer immunotherapy.
Stuart J Gallagher, Elena Shklovskaya, Peter Hersey.
Curr Opin Pharmacol, 2017 Jun 14; 35. PMID: 28609681
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Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation.
K V Woan, M Lienlaf, +20 authors, A Villagra.
Mol Oncol, 2015 May 11; 9(7). PMID: 25957812    Free PMC article.
Molecular and genetic properties of tumors associated with local immune cytolytic activity.
Michael S Rooney, Sachet A Shukla, +2 authors, Nir Hacohen.
Cell, 2015 Jan 17; 160(1-2). PMID: 25594174    Free PMC article.
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The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker.
Denis L Jardim, Aaron Goodman, Debora de Melo Gagliato, Razelle Kurzrock.
Cancer Cell, 2020 Oct 31; 39(2). PMID: 33125859    Free PMC article.
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Characteristics and clinical impacts of the immune environments in colorectal and renal cell carcinoma lung metastases: influence of tumor origin.
Romain Remark, Marco Alifano, +17 authors, Diane Damotte.
Clin Cancer Res, 2013 Jun 21; 19(15). PMID: 23785047
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Familial occurrence of breast cancer is associated with reduced natural killer cytotoxicity.
D R Strayer, W A Carter, I Brodsky.
Breast Cancer Res Treat, 1986 Jan 01; 7(3). PMID: 3779116
Prostaglandin E2 Secreted by Thyroid Cancer Cells Contributes to Immune Escape Through the Suppression of Natural Killer (NK) Cell Cytotoxicity and NK Cell Differentiation.
Arum Park, Yunhee Lee, +7 authors, Suk Ran Yoon.
Front Immunol, 2018 Aug 25; 9. PMID: 30140269    Free PMC article.
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies.
Shogo Kumagai, Yosuke Togashi, +28 authors, Hiroyoshi Nishikawa.
Nat Immunol, 2020 Sep 02; 21(11). PMID: 32868929
Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy.
Tuba N Gide, Camelia Quek, +22 authors, James S Wilmott.
Cancer Cell, 2019 Feb 13; 35(2). PMID: 30753825
Highly Cited.
The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation.
Florencia Cano, Helen Bye, +4 authors, Paul J Lehner.
EMBO J, 2012 Aug 07; 31(17). PMID: 22863774    Free PMC article.
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Sarah Djebali, Carrie A Davis, +82 authors, Thomas R Gingeras.
Nature, 2012 Sep 08; 489(7414). PMID: 22955620    Free PMC article.
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HLA expression in cancer: implications for T cell-based immunotherapy.
A Sette, R Chesnut, J Fikes.
Immunogenetics, 2001 Aug 09; 53(4). PMID: 11491528
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Low natural-killer-cell activity in familial melanoma patients and their relatives.
P Hersey, A Edwards, M Honeyman, W H McCarthy.
Br J Cancer, 1979 Jul 01; 40(1). PMID: 314301    Free PMC article.
Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status.
J Símová, V Polláková, +5 authors, M Reiniš.
Br J Cancer, 2011 Oct 22; 105(10). PMID: 22015556    Free PMC article.
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H F Pross, E Lotzová.
Nat Immun, 1993 Jul 01; 12(4-5). PMID: 8257832
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Uncovering the Tumor Antigen Landscape: What to Know about the Discovery Process.
Sara Feola, Jacopo Chiaro, Beatriz Martins, Vincenzo Cerullo.
Cancers (Basel), 2020 Jun 27; 12(6). PMID: 32585818    Free PMC article.
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M L Wei, P Cresswell.
Nature, 1992 Apr 02; 356(6368). PMID: 1557127
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Prognostic impact of B-cell density in cutaneous melanoma.
Andrea Ladányi, Judit Kiss, +7 authors, József Tímár.
Cancer Immunol Immunother, 2011 Jul 23; 60(12). PMID: 21779876
Identification of essential genes for cancer immunotherapy.
Shashank J Patel, Neville E Sanjana, +21 authors, Nicholas P Restifo.
Nature, 2017 Aug 08; 548(7669). PMID: 28783722    Free PMC article.
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Genetic Mechanisms of Immune Evasion in Colorectal Cancer.
Catherine S Grasso, Marios Giannakis, +49 authors, Ulrike Peters.
Cancer Discov, 2018 Mar 08; 8(6). PMID: 29510987    Free PMC article.
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First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia.
Sarah Cooley, Fiona He, +11 authors, Jeffrey S Miller.
Blood Adv, 2019 Jul 04; 3(13). PMID: 31266741    Free PMC article.
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Most non-canonical proteins uniquely populate the proteome or immunopeptidome.
Maria Virginia Ruiz Cuevas, Marie-Pierre Hardy, +10 authors, Jonathan W Yewdell.
Cell Rep, 2021 Mar 11; 34(10). PMID: 33691108    Free PMC article.
Licensing of natural killer cells by host major histocompatibility complex class I molecules.
Sungjin Kim, Jennifer Poursine-Laurent, +8 authors, Wayne M Yokoyama.
Nature, 2005 Aug 05; 436(7051). PMID: 16079848
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Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer.
Ugur Sahin, Evelyna Derhovanessian, +47 authors, Özlem Türeci.
Nature, 2017 Jul 06; 547(7662). PMID: 28678784
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Role of natural killer cells in tumor growth and metastasis: C57BL/6 normal and beige mice.
J E Talmadge, K M Meyers, D J Prieur, J R Starkey.
J Natl Cancer Inst, 1980 Nov 01; 65(5). PMID: 6933263
Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma.
Willy Hugo, Jesse M Zaretsky, +15 authors, Roger S Lo.
Cell, 2016 Mar 22; 165(1). PMID: 26997480    Free PMC article.
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Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes.
Sachet A Shukla, Michael S Rooney, +14 authors, Gad Getz.
Nat Biotechnol, 2015 Sep 16; 33(11). PMID: 26372948    Free PMC article.
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Classification and characterization of human endogenous retroviruses; mosaic forms are common.
Laura Vargiu, Patricia Rodriguez-Tomé, +5 authors, Jonas Blomberg.
Retrovirology, 2016 Jan 24; 13. PMID: 26800882    Free PMC article.
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Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden.
Zachary R Chalmers, Caitlin F Connelly, +21 authors, Garrett M Frampton.
Genome Med, 2017 Apr 20; 9(1). PMID: 28420421    Free PMC article.
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Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma.
Lizzia Raffaghello, Ignazia Prigione, +7 authors, Vito Pistoia.
Neoplasia, 2004 Nov 19; 6(5). PMID: 15548365    Free PMC article.
Variations in MHC class I antigen presentation and immunopeptidome selection pathways.
Anita J Zaitoua, Amanpreet Kaur, Malini Raghavan.
F1000Res, 2020 Oct 06; 9. PMID: 33014341    Free PMC article.
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Programmed cell death 1-expressing CD56-negative natural killer (NK) cell expansion is a hallmark of chronic NK cell activation during dasatinib treatment.
Ken-Ichi Ishiyama, Toshio Kitawaki, +2 authors, Norimitsu Kadowaki.
Cancer Sci, 2020 Oct 17; 112(2). PMID: 33064914    Free PMC article.
Systemic Interferon-γ Increases MHC Class I Expression and T-cell Infiltration in Cold Tumors: Results of a Phase 0 Clinical Trial.
Shihong Zhang, Karan Kohli, +11 authors, Seth M Pollack.
Cancer Immunol Res, 2019 Jun 07; 7(8). PMID: 31171504    Free PMC article.
Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing.
Samantha L Smith, Philippa R Kennedy, +17 authors, Daniel M Davis.
Blood Adv, 2020 Apr 10; 4(7). PMID: 32271902    Free PMC article.
Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma.
Joshua R Veatch, Sylvia M Lee, +10 authors, Stanley R Riddell.
J Clin Invest, 2018 Jan 24; 128(4). PMID: 29360643    Free PMC article.
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Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells.
Roberta Castriconi, Claudia Cantoni, +7 authors, Alessandro Moretta.
Proc Natl Acad Sci U S A, 2003 Mar 21; 100(7). PMID: 12646700    Free PMC article.
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Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer.
Martin Reck, Delvys Rodríguez-Abreu, +16 authors, KEYNOTE-024 Investigators.
N Engl J Med, 2016 Oct 11; 375(19). PMID: 27718847
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Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade.
Pei-Ling Chen, Whijae Roh, +41 authors, Jennifer A Wargo.
Cancer Discov, 2016 Jun 16; 6(8). PMID: 27301722    Free PMC article.
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NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells.
Francesco Staehli, Kristina Ludigs, +12 authors, Jürg Tschopp.
J Immunol, 2012 Mar 14; 188(8). PMID: 22412192
MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma.
Masahisa Jinushi, Matthew Vanneman, +7 authors, Glenn Dranoff.
Proc Natl Acad Sci U S A, 2008 Jan 19; 105(4). PMID: 18202175    Free PMC article.
NLRC5 promotes cell proliferation via regulating the AKT/VEGF-A signaling pathway in hepatocellular carcinoma.
Ying-Hua He, Ming-Fang Li, +3 authors, Jun Li.
Toxicology, 2016 Jun 25; 359-360. PMID: 27338800
Tumor Killing by CD4+ T Cells Is Mediated via Induction of Inducible Nitric Oxide Synthase-Dependent Macrophage Cytotoxicity.
Marte Fauskanger, Ole Audun Werner Haabeth, +2 authors, Anders Aune Tveita.
Front Immunol, 2018 Aug 08; 9. PMID: 30083157    Free PMC article.
PD-1 blockade induces responses by inhibiting adaptive immune resistance.
Paul C Tumeh, Christina L Harview, +23 authors, Antoni Ribas.
Nature, 2014 Nov 28; 515(7528). PMID: 25428505    Free PMC article.
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Restoration of Natural Killer Cell Antimetastatic Activity by IL12 and Checkpoint Blockade.
Isabel Ohs, Laura Ducimetière, +3 authors, Sonia Tugues.
Cancer Res, 2017 Oct 19; 77(24). PMID: 29042417
HLA class I antigen downregulation in human cancers: T-cell immunotherapy revives an old story.
D J Hicklin, F M Marincola, S Ferrone.
Mol Med Today, 1999 May 18; 5(4). PMID: 10203751
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The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression.
Lu Huang, Shruti Malu, +23 authors, Patrick Hwu.
Clin Cancer Res, 2018 Mar 03; 24(14). PMID: 29496759
TGF-β and EGF induced HLA-I downregulation is associated with epithelial-mesenchymal transition (EMT) through upregulation of snail in prostate cancer cells.
Xiao-Hui Chen, Zong-Cai Liu, +8 authors, Jun Du.
Mol Immunol, 2015 Jan 27; 65(1). PMID: 25618241
CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment.
Shi Yong Neo, Ying Yang, +19 authors, Andreas Lundqvist.
J Clin Invest, 2019 Nov 27; 130(3). PMID: 31770109    Free PMC article.
LincRNA-immunity landscape analysis identifies EPIC1 as a regulator of tumor immune evasion and immunotherapy resistance.
Weiwei Guo, Yue Wang, +15 authors, Da Yang.
Sci Adv, 2021 Feb 12; 7(7). PMID: 33568470    Free PMC article.
Ocular and systemic autoimmunity after successful tumor-infiltrating lymphocyte immunotherapy for recurrent, metastatic melanoma.
Steven Yeh, Neel K Karne, +12 authors, Robert B Nussenblatt.
Ophthalmology, 2009 May 05; 116(5). PMID: 19410956    Free PMC article.
Role of NK cells in the control of metastatic spread and growth of tumor cells in mice.
E Gorelik, R H Wiltrout, +2 authors, R B Herberman.
Int J Cancer, 1982 Jul 15; 30(1). PMID: 7118294
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Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes.
Monica Bernal, Francisco Ruiz-Cabello, +2 authors, Federico Garrido.
Cancer Immunol Immunother, 2012 Jul 27; 61(9). PMID: 22833104
Review.
Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy.
Xiaohong Wang, Jonathan E Schoenhals, +18 authors, James W Welsh.
Cancer Res, 2016 Nov 09; 77(4). PMID: 27821490    Free PMC article.
Highly Cited.
Nuclear processing of nascent transcripts determines synthesis of full-length proteins and antigenic peptides.
Rodrigo Prado Martins, Laurence Malbert-Colas, +6 authors, Robin Fåhraeus.
Nucleic Acids Res, 2019 Jan 10; 47(6). PMID: 30624716    Free PMC article.
Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants.
Loredana Ruggeri, Marusca Capanni, +9 authors, Andrea Velardi.
Science, 2002 Mar 16; 295(5562). PMID: 11896281
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The Microbiome in Immuno-oncology.
Joseph Toker, Reetakshi Arora, Jennifer A Wargo.
Adv Exp Med Biol, 2020 Apr 18; 1244. PMID: 32301026
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Adoptive transfer of vaccine-induced peripheral blood mononuclear cells to patients with metastatic melanoma following lymphodepletion.
Daniel J Powell, Mark E Dudley, +2 authors, Steven A Rosenberg.
J Immunol, 2006 Oct 24; 177(9). PMID: 17056585    Free PMC article.
Accounting for proximal variants improves neoantigen prediction.
Jasreet Hundal, Susanna Kiwala, +8 authors, Malachi Griffith.
Nat Genet, 2018 Dec 05; 51(1). PMID: 30510237    Free PMC article.
Association between natural killer cells and regression in melanocytic lesions.
Kristopher McKay, Page C Moore, Bruce R Smoller, Kim M Hiatt.
Hum Pathol, 2011 Jun 17; 42(12). PMID: 21676435
Determinants for Neoantigen Identification.
Andrea Garcia-Garijo, Carlos Alberto Fajardo, Alena Gros.
Front Immunol, 2019 Jul 12; 10. PMID: 31293573    Free PMC article.
Review.
Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy.
Rami Yossef, Eric Tran, +8 authors, Steven A Rosenberg.
JCI Insight, 2018 Oct 05; 3(19). PMID: 30282837    Free PMC article.
Highly Cited.
CD4 T Cell-Dependent Rejection of Beta-2 Microglobulin Null Mismatch Repair-Deficient Tumors.
Giovanni Germano, Steve Lu, +13 authors, Alberto Bardelli.
Cancer Discov, 2021 Mar 04; 11(7). PMID: 33653693
T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer.
Eric Tran, Paul F Robbins, +9 authors, Steven A Rosenberg.
N Engl J Med, 2016 Dec 14; 375(23). PMID: 27959684    Free PMC article.
Highly Cited.
Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy.
Douglas B Johnson, Monica V Estrada, +18 authors, Justin M Balko.
Nat Commun, 2016 Jan 30; 7. PMID: 26822383    Free PMC article.
Highly Cited.
NLRC5/MHC class I transactivator is a target for immune evasion in cancer.
Sayuri Yoshihama, Jason Roszik, +7 authors, Koichi S Kobayashi.
Proc Natl Acad Sci U S A, 2016 May 11; 113(21). PMID: 27162338    Free PMC article.
Highly Cited.
NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives.
Remy Thomas, Ghaneya Al-Khadairi, +4 authors, Julie Decock.
Front Immunol, 2018 May 18; 9. PMID: 29770138    Free PMC article.
Highly Cited. Review.
The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes.
L L Lanier, A M Le, +2 authors, J H Phillips.
J Immunol, 1986 Jun 15; 136(12). PMID: 3086432
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Immune selection of hot-spot beta 2-microglobulin gene mutations, HLA-A2 allospecificity loss, and antigen-processing machinery component down-regulation in melanoma cells derived from recurrent metastases following immunotherapy.
Chien-Chung Chang, Michael Campoli, +2 authors, Soldano Ferrone.
J Immunol, 2005 Jan 22; 174(3). PMID: 15661905    Free PMC article.
Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines.
B Fisk, T L Blevins, J T Wharton, C G Ioannides.
J Exp Med, 1995 Jun 01; 181(6). PMID: 7539040    Free PMC article.
Highly Cited.
Interferon Signaling Is Frequently Downregulated in Melanoma.
Sara Alavi, Ashleigh Jacqueline Stewart, +3 authors, Helen Rizos.
Front Immunol, 2018 Jul 07; 9. PMID: 29977240    Free PMC article.
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.
Robert T Manguso, Hans W Pope, +16 authors, W Nicholas Haining.
Nature, 2017 Jul 21; 547(7664). PMID: 28723893    Free PMC article.
Highly Cited.
Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.
Pia Kvistborg, Daisy Philips, +13 authors, Ton N Schumacher.
Sci Transl Med, 2014 Sep 19; 6(254). PMID: 25232180
Highly Cited.
Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer.
Eric Tran, Simon Turcotte, +10 authors, Steven A Rosenberg.
Science, 2014 May 09; 344(6184). PMID: 24812403    Free PMC article.
Highly Cited.
CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma.
D Mumberg, P A Monach, +4 authors, H Schreiber.
Proc Natl Acad Sci U S A, 1999 Jul 21; 96(15). PMID: 10411927    Free PMC article.
Highly Cited.
Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy.
Diego Chowell, Chirag Krishna, +7 authors, Timothy A Chan.
Nat Med, 2019 Nov 09; 25(11). PMID: 31700181    Free PMC article.
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Daniel Sanghoon Shin, Jesse M Zaretsky, +24 authors, Antoni Ribas.
Cancer Discov, 2016 Dec 03; 7(2). PMID: 27903500    Free PMC article.
Highly Cited.
Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer.
Hossein Borghaei, Luis Paz-Ares, +25 authors, Julie R Brahmer.
N Engl J Med, 2015 Sep 29; 373(17). PMID: 26412456    Free PMC article.
Highly Cited.
Decitabine facilitates immune recognition of sarcoma cells by upregulating CT antigens, MHC molecules, and ICAM-1.
Deepa Kolaseri Krishnadas, Lei Bao, +2 authors, Kenneth Lucas.
Tumour Biol, 2014 Mar 04; 35(6). PMID: 24584817
Pro- and anti-tumour effects of B cells and antibodies in cancer: a comparison of clinical studies and preclinical models.
Thomas V Guy, Alexandra M Terry, +3 authors, Barbara Fazekas de St. Groth.
Cancer Immunol Immunother, 2016 May 26; 65(8). PMID: 27222052
Review.
Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer.
Charu Aggarwal, Roger B Cohen, +21 authors, Mark L Bagarazzi.
Clin Cancer Res, 2018 Sep 23; 25(1). PMID: 30242022    Free PMC article.
Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma.
Cathrin Ritter, Kaiji Fan, +6 authors, Jürgen C Becker.
Sci Rep, 2017 May 26; 7(1). PMID: 28536458    Free PMC article.
Generation of CD8+ T cells specific for transporter associated with antigen processing deficient cells.
E Z Wolpert, M Petersson, +4 authors, K Kärre.
Proc Natl Acad Sci U S A, 1997 Oct 23; 94(21). PMID: 9326638    Free PMC article.
TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors.
Elien M Doorduijn, Marjolein Sluijter, +5 authors, Thorbald van Hall.
J Clin Invest, 2016 Jan 20; 126(2). PMID: 26784543    Free PMC article.
Endogenous retrovirus expression is required for murine melanoma tumor growth in vivo.
Marianne Mangeney, Julien Pothlichet, +2 authors, Thierry Heidmann.
Cancer Res, 2005 Apr 05; 65(7). PMID: 15805254
Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.
S Bauer, V Groh, +4 authors, T Spies.
Science, 1999 Jul 31; 285(5428). PMID: 10426993
Highly Cited.
Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.
Ying Xie, Akgül Akpinarli, +6 authors, Paul Andrew Antony.
J Exp Med, 2010 Feb 17; 207(3). PMID: 20156973    Free PMC article.
Highly Cited.
Neoantigen prediction and computational perspectives towards clinical benefit: recommendations from the ESMO Precision Medicine Working Group.
L De Mattos-Arruda, M Vazquez, +12 authors, M Griffith.
Ann Oncol, 2020 Jul 02; 31(8). PMID: 32610166    Free PMC article.
Systematic Review.
Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors.
Vid Leko, Steven A Rosenberg.
Cancer Cell, 2020 Aug 22; 38(4). PMID: 32822573    Free PMC article.
Review.
NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module.
Kristina Ludigs, Queralt Seguín-Estévez, +7 authors, Greta Guarda.
PLoS Genet, 2015 Mar 27; 11(3). PMID: 25811463    Free PMC article.
Helping the CD8(+) T-cell response.
Michael J Bevan.
Nat Rev Immunol, 2004 Aug 03; 4(8). PMID: 15286726
Highly Cited. Review.
Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells.
Paul F Robbins, Yong-Chen Lu, +9 authors, Steven A Rosenberg.
Nat Med, 2013 May 07; 19(6). PMID: 23644516    Free PMC article.
Highly Cited.
NLR family member NLRC5 is a transcriptional regulator of MHC class I genes.
Torsten B Meissner, Amy Li, +6 authors, Koichi S Kobayashi.
Proc Natl Acad Sci U S A, 2010 Jul 20; 107(31). PMID: 20639463    Free PMC article.
Highly Cited.
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.
Nicholas McGranahan, Andrew J S Furness, +33 authors, Charles Swanton.
Science, 2016 Mar 05; 351(6280). PMID: 26940869    Free PMC article.
Highly Cited.
PD-1+ natural killer cells in human non-small cell lung cancer can be activated by PD-1/PD-L1 blockade.
Marcel P Trefny, Monika Kaiser, +7 authors, Alfred Zippelius.
Cancer Immunol Immunother, 2020 Apr 17; 69(8). PMID: 32296919
Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma.
Anusha Kalbasi, Mito Tariveranmoshabad, +15 authors, Antoni Ribas.
Sci Transl Med, 2020 Oct 16; 12(565). PMID: 33055240    Free PMC article.
Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma.
James Larkin, Vanna Chiarion-Sileni, +28 authors, Jedd D Wolchok.
N Engl J Med, 2019 Sep 29; 381(16). PMID: 31562797
Highly Cited.
Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding.
Helmut R Salih, Hans-Georg Rammensee, Alexander Steinle.
J Immunol, 2002 Oct 09; 169(8). PMID: 12370336
Highly Cited.
Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy.
Razvan Cristescu, Robin Mogg, +21 authors, David Kaufman.
Science, 2018 Oct 13; 362(6411). PMID: 30309915    Free PMC article.
Highly Cited.
The Immune Landscape of Cancer.
Vésteinn Thorsson, David L Gibbs, +55 authors, Ilya Shmulevich.
Immunity, 2018 Apr 10; 48(4). PMID: 29628290    Free PMC article.
Highly Cited.
Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein.
Philippe Boutet, Sonia Agüera-González, +5 authors, Mar Valés-Gómez.
J Immunol, 2008 Dec 26; 182(1). PMID: 19109134
Phase I Trial of Expanded, Activated Autologous NK-cell Infusions with Trastuzumab in Patients with HER2-positive Cancers.
Soo-Chin Lee, Noriko Shimasaki, +20 authors, Dario Campana.
Clin Cancer Res, 2020 Jun 12; 26(17). PMID: 32522887
A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma.
P van der Bruggen, C Traversari, +5 authors, T Boon.
Science, 1991 Dec 13; 254(5038). PMID: 1840703
Highly Cited.
Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion.
Andrew J Freeman, Stephin J Vervoort, +6 authors, Jane Oliaro.
Cell Rep, 2019 Sep 12; 28(11). PMID: 31509742
Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.
Samra Turajlic, Kevin Litchfield, +17 authors, Charles Swanton.
Lancet Oncol, 2017 Jul 12; 18(8). PMID: 28694034
Highly Cited.
TEIPP antigens for T-cell based immunotherapy of immune-edited HLA class Ilow cancers.
Koen A Marijt, Elien M Doorduijn, Thorbald van Hall.
Mol Immunol, 2018 Apr 09; 113. PMID: 29627136
Review.
Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17.
Guranda Chitadze, Marcus Lettau, +8 authors, Dieter Kabelitz.
Int J Cancer, 2013 Mar 26; 133(7). PMID: 23526433
The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients.
Vyara Matson, Jessica Fessler, +5 authors, Thomas F Gajewski.
Science, 2018 Jan 06; 359(6371). PMID: 29302014    Free PMC article.
Highly Cited.
Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues.
Jean-David Larouche, Assya Trofimov, +11 authors, Claude Perreault.
Genome Med, 2020 Apr 30; 12(1). PMID: 32345368    Free PMC article.
TGF-β-inducible microRNA-183 silences tumor-associated natural killer cells.
Sarah S Donatelli, Jun-Min Zhou, +8 authors, Julie Y Djeu.
Proc Natl Acad Sci U S A, 2014 Mar 04; 111(11). PMID: 24586048    Free PMC article.
Highly Cited.
Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade.
Joseph L Benci, Bihui Xu, +16 authors, Andy J Minn.
Cell, 2016 Dec 03; 167(6). PMID: 27912061    Free PMC article.
Highly Cited.
MHC class I dysfunction of glioma stem cells escapes from CTL-mediated immune response via activation of Wnt/β-catenin signaling pathway.
Wei Yang, Yanyan Li, +2 authors, Ting Sun.
Oncogene, 2019 Oct 09; 39(5). PMID: 31591480
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients.
V Gopalakrishnan, C N Spencer, +67 authors, J A Wargo.
Science, 2017 Nov 04; 359(6371). PMID: 29097493    Free PMC article.
Highly Cited.
To TAP or not to TAP: alternative peptides for immunotherapy of cancer.
Koen A Marijt, Thorbald van Hall.
Curr Opin Immunol, 2020 Jan 18; 64. PMID: 31952027
Review.
Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA.
K G Paulson, V Voillet, +20 authors, A G Chapuis.
Nat Commun, 2018 Sep 27; 9(1). PMID: 30250229    Free PMC article.
Highly Cited.
Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress.
Jennifer Tsoi, Lidia Robert, +12 authors, Thomas G Graeber.
Cancer Cell, 2018 Apr 17; 33(5). PMID: 29657129    Free PMC article.
Highly Cited.
Impact of tumor heterogeneity and microenvironment in identifying neoantigens in a patient with ovarian cancer.
Tao Dao, Martin G Klatt, +8 authors, David A Scheinberg.
Cancer Immunol Immunother, 2020 Oct 31; 70(5). PMID: 33123756    Free PMC article.
Cutting edge: impaired MHC class I expression in mice deficient for Nlrc5/class I transactivator.
Amlan Biswas, Torsten B Meissner, Taro Kawai, Koichi S Kobayashi.
J Immunol, 2012 Jun 20; 189(2). PMID: 22711889    Free PMC article.
Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen.
Elena Shklovskaya, Alexandra M Terry, +5 authors, Barbara Fazekas de St. Groth.
Immunol Cell Biol, 2016 Feb 04; 94(6). PMID: 26837456
Tertiary lymphoid structures improve immunotherapy and survival in melanoma.
Rita Cabrita, Martin Lauss, +22 authors, Göran Jönsson.
Nature, 2020 Jan 17; 577(7791). PMID: 31942071
Highly Cited.
Tumor Mutational Burden and Response Rate to PD-1 Inhibition.
Mark Yarchoan, Alexander Hopkins, Elizabeth M Jaffee.
N Engl J Med, 2017 Dec 21; 377(25). PMID: 29262275    Free PMC article.
Highly Cited.
STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity.
Rana Falahat, Patricio Perez-Villarroel, +4 authors, James J Mulé.
Cancer Immunol Res, 2019 Aug 30; 7(11). PMID: 31462408    Free PMC article.
Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma.
Nienke van Rooij, Marit M van Buuren, +14 authors, Ton N Schumacher.
J Clin Oncol, 2013 Sep 18; 31(32). PMID: 24043743    Free PMC article.
Highly Cited.
Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma.
Jedd D Wolchok, Vanna Chiarion-Sileni, +30 authors, James Larkin.
N Engl J Med, 2017 Sep 12; 377(14). PMID: 28889792    Free PMC article.
Highly Cited.
Neoantigen-reactive T cells exhibit effective anti-tumor activity against colorectal cancer.
Yaojun Yu, Jing Zhang, +11 authors, Zhenzhai Cai.
Hum Vaccin Immunother, 2021 Mar 11; 18(1). PMID: 33689574    Free PMC article.
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade.
Michael A Postow, Robert Sidlow, Matthew D Hellmann.
N Engl J Med, 2018 Jan 11; 378(2). PMID: 29320654
Highly Cited. Review.
CD16+NKG2Ahigh Natural Killer Cells Infiltrate Breast Cancer-Draining Lymph Nodes.
Alexandra Frazao, Meriem Messaoudene, +7 authors, Anne Caignard.
Cancer Immunol Res, 2018 Dec 06; 7(2). PMID: 30514793
Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions.
Antje Sucker, Fang Zhao, +20 authors, Annette Paschen.
Nat Commun, 2017 Jun 01; 8. PMID: 28561041    Free PMC article.
Highly Cited.
Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma.
Shelly Kalaora, Yochai Wolf, +30 authors, Yardena Samuels.
Cancer Discov, 2018 Sep 14; 8(11). PMID: 30209080    Free PMC article.
MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma.
Scott J Rodig, Daniel Gusenleitner, +13 authors, F Stephen Hodi.
Sci Transl Med, 2018 Jul 20; 10(450). PMID: 30021886
Highly Cited.
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.
Christina Twyman-Saint Victor, Andrew J Rech, +22 authors, Andy J Minn.
Nature, 2015 Mar 11; 520(7547). PMID: 25754329    Free PMC article.
Highly Cited.
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.
James Larkin, Vanna Chiarion-Sileni, +28 authors, Jedd D Wolchok.
N Engl J Med, 2015 Jun 02; 373(1). PMID: 26027431    Free PMC article.
Highly Cited.
MHC-II neoantigens shape tumour immunity and response to immunotherapy.
Elise Alspach, Danielle M Lussier, +20 authors, Robert D Schreiber.
Nature, 2019 Oct 28; 574(7780). PMID: 31645760    Free PMC article.
Highly Cited.
Mechanisms of loss of HLA class I expression on colorectal tumor cells.
M Browning, F Petronzelli, +6 authors, W Bodmer.
Tissue Antigens, 1996 May 01; 47(5). PMID: 8795136
NY-BR-1 protein expression in breast carcinoma: a mammary gland differentiation antigen as target for cancer immunotherapy.
Jean-Philippe Theurillat, Ursina Zürrer-Härdi, +12 authors, Holger Moch.
Cancer Immunol Immunother, 2007 Apr 06; 56(11). PMID: 17410359
Alternative tumour-specific antigens.
Christof C Smith, Sara R Selitsky, +3 authors, Jonathan S Serody.
Nat Rev Cancer, 2019 Jul 07; 19(8). PMID: 31278396    Free PMC article.
Highly Cited. Review.
Persistence of memory CD8 T cells in MHC class I-deficient mice.
K Murali-Krishna, L L Lau, +3 authors, R Ahmed.
Science, 1999 Nov 13; 286(5443). PMID: 10558996
Highly Cited.
A potential role for immunotherapy in thyroid cancer by enhancing NY-ESO-1 cancer antigen expression.
Viswanath Gunda, Dennie T Frederick, +2 authors, Sareh Parangi.
Thyroid, 2014 May 09; 24(8). PMID: 24811699    Free PMC article.
Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity.
Greta Garrido, Brett Schrand, +10 authors, Eli Gilboa.
Nat Commun, 2019 Aug 23; 10(1). PMID: 31434881    Free PMC article.
Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts.
Sergio A Quezada, Tyler R Simpson, +9 authors, James P Allison.
J Exp Med, 2010 Feb 17; 207(3). PMID: 20156971    Free PMC article.
Highly Cited.
Bystander killing of cancer requires the cooperation of CD4(+) and CD8(+) T cells during the effector phase.
Andrea Schietinger, Mary Philip, +2 authors, Hans Schreiber.
J Exp Med, 2010 Oct 06; 207(11). PMID: 20921286    Free PMC article.
Mapping the MHC Class I-Spliced Immunopeptidome of Cancer Cells.
Juliane Liepe, John Sidney, +2 authors, Michele Mishto.
Cancer Immunol Res, 2018 Nov 15; 7(1). PMID: 30425108
Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells.
Alessandra Zingoni, Francesca Cecere, +12 authors, Angela Santoni.
J Immunol, 2015 Jun 14; 195(2). PMID: 26071561
Neoantigen landscape dynamics during human melanoma-T cell interactions.
Els M E Verdegaal, Noel F C C de Miranda, +11 authors, Sjoerd H van der Burg.
Nature, 2016 Jun 29; 536(7614). PMID: 27350335
Highly Cited.
Licensed and Unlicensed NK Cells: Differential Roles in Cancer and Viral Control.
Megan M Tu, Ahmad Bakur Mahmoud, Andrew P Makrigiannis.
Front Immunol, 2016 May 21; 7. PMID: 27199990    Free PMC article.
Review.
NetMHCpan-4.0: Improved Peptide-MHC Class I Interaction Predictions Integrating Eluted Ligand and Peptide Binding Affinity Data.
Vanessa Jurtz, Sinu Paul, +3 authors, Morten Nielsen.
J Immunol, 2017 Oct 06; 199(9). PMID: 28978689    Free PMC article.
Highly Cited.
Neoantigens in cancer immunotherapy.
Ton N Schumacher, Robert D Schreiber.
Science, 2015 Apr 04; 348(6230). PMID: 25838375
Highly Cited. Review.
Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma.
Alexandre Reuben, Christine N Spencer, +51 authors, Jennifer A Wargo.
NPJ Genom Med, 2017 Aug 19; 2. PMID: 28819565    Free PMC article.
Highly Cited.
Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers.
Anu Sharma, Sumit K Subudhi, +6 authors, Padmanee Sharma.
Clin Cancer Res, 2018 Jul 29; 25(4). PMID: 30054281    Free PMC article.
Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
A Review of Viral-Related Malignancies and the Associated Imaging Findings.
Nikita Consul, Christine O Menias, +4 authors, Khaled M Elsayes.
AJR Am J Roentgenol, 2019 Oct 09; 214(1). PMID: 31593515
Review.
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
Bertrand Routy, Emmanuelle Le Chatelier, +45 authors, Laurence Zitvogel.
Science, 2017 Nov 04; 359(6371). PMID: 29097494
Highly Cited.
CD4+ T cells indirectly kill tumor cells via induction of cytotoxic macrophages in mouse models.
Bjarne Bogen, Marte Fauskanger, Ole Audun Haabeth, Anders Tveita.
Cancer Immunol Immunother, 2019 Aug 27; 68(11). PMID: 31448380
Review.
Mutant MHC class II epitopes drive therapeutic immune responses to cancer.
Sebastian Kreiter, Mathias Vormehr, +12 authors, Ugur Sahin.
Nature, 2015 Apr 23; 520(7549). PMID: 25901682    Free PMC article.
Highly Cited.
Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade.
Joseph L Benci, Lexus R Johnson, +14 authors, Andy J Minn.
Cell, 2019 Aug 10; 178(4). PMID: 31398344    Free PMC article.
Highly Cited.
Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia.
Rizwan Romee, Maximillian Rosario, +15 authors, Todd A Fehniger.
Sci Transl Med, 2016 Sep 23; 8(357). PMID: 27655849    Free PMC article.
Highly Cited.
Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells.
Maria R Parkhurst, Jayne Joo, +4 authors, Steven A Rosenberg.
Clin Cancer Res, 2009 Jan 02; 15(1). PMID: 19118044    Free PMC article.
Association of antigen-processing machinery and HLA antigen phenotype of melanoma cells with survival in American Joint Committee on Cancer stage III and IV melanoma patients.
Andrea Anichini, Roberta Mortarini, +5 authors, Soldano Ferrone.
Cancer Res, 2006 Jun 17; 66(12). PMID: 16778219
Cancer immune escape: MHC expression in primary tumours versus metastases.
Federico Garrido, Natalia Aptsiauri.
Immunology, 2019 Sep 12; 158(4). PMID: 31509607    Free PMC article.
Review.
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.
Michal Bassani-Sternberg, Eva Bräunlein, +16 authors, Angela M Krackhardt.
Nat Commun, 2016 Nov 22; 7. PMID: 27869121    Free PMC article.
Highly Cited.
Signatures of mutational processes in human cancer.
Ludmil B Alexandrov, Serena Nik-Zainal, +72 authors, Michael R Stratton.
Nature, 2013 Aug 16; 500(7463). PMID: 23945592    Free PMC article.
Highly Cited.
Integrated molecular and immunophenotypic analysis of NK cells in anti-PD-1 treated metastatic melanoma patients.
Hansol Lee, Camelia Quek, +19 authors, James S Wilmott.
Oncoimmunology, 2019 Feb 05; 8(2). PMID: 30713793    Free PMC article.
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.
Angel Garcia-Diaz, Daniel Sanghoon Shin, +16 authors, Antoni Ribas.
Cell Rep, 2017 May 13; 19(6). PMID: 28494868    Free PMC article.
Highly Cited.
Noncoding regions are the main source of targetable tumor-specific antigens.
Céline M Laumont, Krystel Vincent, +16 authors, Claude Perreault.
Sci Transl Med, 2018 Dec 07; 10(470). PMID: 30518613
Highly Cited.
Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance.
Whijae Roh, Pei-Ling Chen, +37 authors, P Andrew Futreal.
Sci Transl Med, 2017 Mar 03; 9(379). PMID: 28251903    Free PMC article.
Highly Cited.
Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non-Small Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab.
Brandon W Higgs, Christopher A Morehouse, +4 authors, Koustubh Ranade.
Clin Cancer Res, 2018 May 03; 24(16). PMID: 29716923
Tumor immune microenvironment and nivolumab efficacy in EGFR mutation-positive non-small-cell lung cancer based on T790M status after disease progression during EGFR-TKI treatment.
K Haratani, H Hayashi, +19 authors, K Nakagawa.
Ann Oncol, 2017 Apr 14; 28(7). PMID: 28407039
Highly Cited.
High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma.
Carsten Linnemann, Marit M van Buuren, +13 authors, Ton N M Schumacher.
Nat Med, 2014 Dec 23; 21(1). PMID: 25531942
Highly Cited.
Genome-Wide CRISPR Screen Reveals Cancer Cell Resistance to NK Cells Induced by NK-Derived IFN-γ.
Xiaoxuan Zhuang, Daniel P Veltri, Eric O Long.
Front Immunol, 2020 Jan 11; 10. PMID: 31921143    Free PMC article.
HLA-E: a novel player for histocompatibility.
Thomas Kraemer, Rainer Blasczyk, Christina Bade-Doeding.
J Immunol Res, 2014 Nov 18; 2014. PMID: 25401109    Free PMC article.
Review.
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer.
Thomas Powles, Joseph Paul Eder, +12 authors, Nicholas J Vogelzang.
Nature, 2014 Nov 28; 515(7528). PMID: 25428503
Highly Cited.
NLRC5 regulates cell proliferation, migration and invasion in hepatocellular carcinoma by targeting the Wnt/β-catenin signaling pathway.
Yun-Yun Peng, Ying-Hua He, +6 authors, Jun Li.
Cancer Lett, 2016 Mar 16; 376(1). PMID: 26975630
Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response.
Mariëtte I E van Poelgeest, Marij J P Welters, +24 authors, Sjoerd H van der Burg.
Clin Cancer Res, 2016 Jan 28; 22(10). PMID: 26813357
Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity.
Emilie Mamessier, Aude Sylvain, +12 authors, Daniel Olive.
J Clin Invest, 2011 Aug 16; 121(9). PMID: 21841316    Free PMC article.
Highly Cited.
Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance.
Jiajie Wei, Rigel J Kishton, +18 authors, Jonathan W Yewdell.
Mol Cell, 2019 Feb 05; 73(6). PMID: 30712990    Free PMC article.
Cancer regression in patients after transfer of genetically engineered lymphocytes.
Richard A Morgan, Mark E Dudley, +13 authors, Steven A Rosenberg.
Science, 2006 Sep 02; 314(5796). PMID: 16946036    Free PMC article.
Highly Cited.
A subset of patients with MSS/MSI-low-colorectal cancer showed increased CD8(+) TILs together with up-regulated IFN-γ.
Tomohiro Kikuchi, Kosaku Mimura, +12 authors, Koji Kono.
Oncol Lett, 2019 Dec 04; 18(6). PMID: 31788072    Free PMC article.
A Phase 1 Trial of CNDO-109-Activated Natural Killer Cells in Patients with High-Risk Acute Myeloid Leukemia.
Todd A Fehniger, Jeffrey S Miller, +11 authors, Eric Rowinsky.
Biol Blood Marrow Transplant, 2018 Mar 30; 24(8). PMID: 29597002    Free PMC article.
Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence.
Michal Harel, Rona Ortenberg, +23 authors, Tamar Geiger.
Cell, 2019 Sep 10; 179(1). PMID: 31495571    Free PMC article.
LYRA, a webserver for lymphocyte receptor structural modeling.
Michael Schantz Klausen, Mads Valdemar Anderson, +2 authors, Paolo Marcatili.
Nucleic Acids Res, 2015 May 27; 43(W1). PMID: 26007650    Free PMC article.
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer.
Julie Brahmer, Karen L Reckamp, +22 authors, David R Spigel.
N Engl J Med, 2015 Jun 02; 373(2). PMID: 26028407    Free PMC article.
Highly Cited.
Cancer Associated Endogenous Retroviruses: Ideal Immune Targets for Adenovirus-Based Immunotherapy.
Amaia Vergara Bermejo, Emeline Ragonnaud, Joana Daradoumis, Peter Holst.
Int J Mol Sci, 2020 Jul 12; 21(14). PMID: 32650622    Free PMC article.
Review.
NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells.
Ximena L Raffo Iraolagoitia, Raul G Spallanzani, +9 authors, Mercedes B Fuertes.
J Immunol, 2016 Jun 28; 197(3). PMID: 27342842
NK cells negatively regulate antigen presentation and tumor-specific CTLs in a syngeneic lymphoma model.
Melissa A Barber, Tong Zhang, Bethany A Gagne, Charles L Sentman.
J Immunol, 2007 May 04; 178(10). PMID: 17475840
Phase 1 clinical trial using mbIL21 ex vivo-expanded donor-derived NK cells after haploidentical transplantation.
Stefan O Ciurea, Jolie R Schafer, +13 authors, Richard E Champlin.
Blood, 2017 Aug 25; 130(16). PMID: 28835441    Free PMC article.
Highly Cited.
Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inhibitor Response.
Meagan Montesion, Karthikeyan Murugesan, +18 authors, Lee A Albacker.
Cancer Discov, 2020 Nov 01; 11(2). PMID: 33127846
Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands.
Brett K Kaiser, Daesong Yim, +6 authors, Thomas Spies.
Nature, 2007 May 15; 447(7143). PMID: 17495932
Highly Cited.
Immunoproteasomes: structure, function, and antigen presentation.
Deborah A Ferrington, Dale S Gregerson.
Prog Mol Biol Transl Sci, 2012 Jun 26; 109. PMID: 22727420    Free PMC article.
Highly Cited. Review.
pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens.
Jasreet Hundal, Beatriz M Carreno, +4 authors, Malachi Griffith.
Genome Med, 2016 Jan 31; 8(1). PMID: 26825632    Free PMC article.
Highly Cited.
Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells.
A Nazmul H Khan, Christopher J Gregorie, Thomas B Tomasi.
Cancer Immunol Immunother, 2007 Nov 30; 57(5). PMID: 18046553    Free PMC article.
DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer.
Na Luo, Mellissa J Nixon, +10 authors, Justin M Balko.
Nat Commun, 2018 Jan 18; 9(1). PMID: 29339738    Free PMC article.
Highly Cited.
Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer.
David Y Oh, Serena S Kwek, +17 authors, Lawrence Fong.
Cell, 2020 Jun 05; 181(7). PMID: 32497499    Free PMC article.
Idiotype-specific CD4(+) T cells eradicate disseminated myeloma.
O A Haabeth, A Tveita, +3 authors, B Bogen.
Leukemia, 2015 Oct 10; 30(5). PMID: 26449664
Allele-Independent Turnover of Human Leukocyte Antigen (HLA) Class Ia Molecules.
Claudia Prevosto, M Farooq Usmani, +6 authors, Robert Busch.
PLoS One, 2016 Aug 17; 11(8). PMID: 27529174    Free PMC article.
Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade.
Ines Pires da Silva, Anne Gallois, +5 authors, Nina Bhardwaj.
Cancer Immunol Res, 2014 May 06; 2(5). PMID: 24795354    Free PMC article.
Highly Cited.
Characterization of the major histocompatibility complex class I deficiencies in B16 melanoma cells.
B Seliger, U Wollscheid, +2 authors, C Huber.
Cancer Res, 2001 Feb 28; 61(3). PMID: 11221838
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype.
Daniel Hirschhorn-Cymerman, Sadna Budhu, +10 authors, Jedd D Wolchok.
J Exp Med, 2012 Sep 26; 209(11). PMID: 23008334    Free PMC article.
An integrative approach to CTL epitope prediction: a combined algorithm integrating MHC class I binding, TAP transport efficiency, and proteasomal cleavage predictions.
Mette Voldby Larsen, Claus Lundegaard, +4 authors, Morten Nielsen.
Eur J Immunol, 2005 Jul 06; 35(8). PMID: 15997466
Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial.
Frank Stephen Hodi, Vanna Chiarion-Sileni, +16 authors, Jedd D Wolchok.
Lancet Oncol, 2018 Oct 27; 19(11). PMID: 30361170
Highly Cited.
Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours.
Aurélie Durgeau, Yasemin Virk, +16 authors, Fathia Mami-Chouaib.
Nat Commun, 2018 Dec 07; 9(1). PMID: 30504837    Free PMC article.
First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer.
David P Carbone, Martin Reck, +27 authors, CheckMate 026 Investigators.
N Engl J Med, 2017 Jun 22; 376(25). PMID: 28636851    Free PMC article.
Highly Cited.
The Origin and Immune Recognition of Tumor-Specific Antigens.
Anca Apavaloaei, Marie-Pierre Hardy, Pierre Thibault, Claude Perreault.
Cancers (Basel), 2020 Sep 17; 12(9). PMID: 32932620    Free PMC article.
Review.
Frequent loss of heterozygosity in the β2-microglobulin region of chromosome 15 in primary human tumors.
Isabel Maleno, Natalia Aptsiauri, +4 authors, Federico Garrido.
Immunogenetics, 2010 Nov 19; 63(2). PMID: 21086121
NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens.
Yikun Yao, Yalong Wang, +6 authors, Youcun Qian.
Cell Res, 2012 Apr 12; 22(5). PMID: 22491475    Free PMC article.
Intratumoral nanoplexed poly I:C BO-112 in combination with systemic anti-PD-1 for patients with anti-PD-1-refractory tumors.
Iván Márquez-Rodas, Federico Longo, +24 authors, Ignacio Melero.
Sci Transl Med, 2020 Oct 16; 12(565). PMID: 33055241
CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism.
P Shrikant, A Khoruts, M F Mescher.
Immunity, 1999 Nov 05; 11(4). PMID: 10549630
HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance.
M Campoli, S Ferrone.
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Highly Cited. Review.
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