Journal Article
. 2021 Aug; 11(8):.
doi: 10.3390/life11080835.

Identification of Autophagy- and Ferroptosis-Related lncRNAs Functioned through Immune-Related Pathways in Head and Neck Squamous Carcinoma

Qi Guo 1 Xuehan Zhang 1 Tao Shen 1 Xiangting Wang 1 
Affiliations
  • PMID: 34440579
  •     104 References
  •     2 citations

Abstract

The interplay between autophagy and ferroptosis has been highlighted as an important event to decide cancer cell fate. However, the underlying mechanisms remain largely unclear. In this study, we systematically explored the expression, prognostic value and functional roles of lncRNA in autophagy and ferroptosis. By a set of bioinformatics analyses, we identified 363 autophagy- and ferroptosis-related lncRNAs (AF-lncRNAs) and found 17 of them are dramatically related to the prognosis of head and neck squamous cell carcinoma (HNSC) patients, named as prognosis-related AF-lncRNAs (PAF-lncRNAs). Based on six key PAF-lncRNAs, a risk score model was developed and used to categorize the TCGA-retrieved HNSC patients into two groups (high-risk vs. low-risk). Functional analysis showed the differentially expressed genes (DEGs) between the two groups were mainly enriched in immune-related pathways and regulated by a PAF-lncRNA-directed ceRNA (competitive endogenous RNA) network. Combined with a variety of immune infiltration analyses, we also found a decreased landscape of immune cell infiltration in high-risk groups. Together, by revealing PAF-lncRNAs with tumor prognostic features functioned through immune-related pathways, our work would contribute to show the pathogenesis of a lncRNA-directed interplay among autophagy, ferroptosis and tumor immunity in HNSC and to develop potential prognostic biomarkers and targets for tumor immunotherapy.

Keywords: autophagy; ferroptosis; head and neck squamous carcinoma; immune cell infiltration; long non-coding RNA; risk model.

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases.
Xiaohua Song, Dingxin Long.
Front Neurosci, 2020 May 07; 14. PMID: 32372896    Free PMC article.
Review.
Landscape of associations between long non-coding RNAs and infiltrating immune cells in liver hepatocellular carcinoma.
Li Li, Xiaowei Song, +3 authors, Dayong Huang.
J Cell Mol Med, 2020 Sep 11; 24(19). PMID: 32910548    Free PMC article.
Development of a Machine Learning-Based Autophagy-Related lncRNA Signature to Improve Prognosis Prediction in Osteosarcoma Patients.
Guang-Zhi Zhang, Zuo-Long Wu, +4 authors, Qi-Qi Xie.
Front Mol Biosci, 2021 Jun 08; 8. PMID: 34095215    Free PMC article.
LncRNA MIR4435-2HG mediates cisplatin resistance in HCT116 cells by regulating Nrf2 and HO-1.
Ping Luo, Shugui Wu, +6 authors, Xiaoming Zhong.
PLoS One, 2020 Nov 25; 15(11). PMID: 33232319    Free PMC article.
lncRNA MIR4435-2HG promoted clear cell renal cell carcinoma malignant progression via miR-513a-5p/KLF6 axis.
Kai Zhu, Chenkui Miao, +7 authors, Zengjun Wang.
J Cell Mol Med, 2021 Jan 19; 24(17). PMID: 33460239    Free PMC article.
Characterization of the Immune Cell Infiltration Landscape in Head and Neck Squamous Cell Carcinoma to Aid Immunotherapy.
Xinhai Zhang, Mengqi Shi, Tielou Chen, Boxin Zhang.
Mol Ther Nucleic Acids, 2020 Nov 25; 22. PMID: 33230435    Free PMC article.
LncRNA MIR4435-2HG triggers ovarian cancer progression by regulating miR-128-3p/CKD14 axis.
Lijuan Zhu, Aihua Wang, +2 authors, Zehua Li.
Cancer Cell Int, 2020 May 08; 20. PMID: 32377170    Free PMC article.
Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway.
Mao-Ling Huang, Cheng-Lin Qi, +6 authors, Shi-Ming Chen.
J Cell Mol Med, 2020 May 30; 24(14). PMID: 32468683    Free PMC article.
7SK Acts as an Anti-tumor Factor in Tongue Squamous Cell Carcinoma.
Bowen Zhang, Sainan Min, +6 authors, Xiangting Wang.
Front Genet, 2021 Apr 20; 12. PMID: 33868377    Free PMC article.
RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts.
Sarah Geisler, Jeff Coller.
Nat Rev Mol Cell Biol, 2013 Oct 10; 14(11). PMID: 24105322    Free PMC article.
Highly Cited. Review.
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
Daiha Shin, Eun Hye Kim, Jaewang Lee, Jong-Lyel Roh.
Free Radic Biol Med, 2018 Oct 20; 129. PMID: 30339884
LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells.
H Xiong, Z Ni, +13 authors, F He.
Oncogene, 2017 Feb 07; 36(25). PMID: 28166203
Highly Cited.
LncRNA PCED1B-AS1 activates the proliferation and restricts the apoptosis of glioma through cooperating with miR-194-5p/PCED1B axis.
Jinghui Yang, Duo Yu, +2 authors, Shan Yu.
J Cell Biochem, 2019 Nov 05; 121(2). PMID: 31680313
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
Vladimir Kirkin, Trond Lamark, +15 authors, Terje Johansen.
Mol Cell, 2009 Mar 03; 33(4). PMID: 19250911
Highly Cited.
FGF5 as an oncogenic factor in human glioblastoma multiforme: autocrine and paracrine activities.
S Allerstorfer, G Sonvilla, +16 authors, W Berger.
Oncogene, 2008 Mar 26; 27(30). PMID: 18362893    Free PMC article.
Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy.
Sacha Gnjatic, Vincenzo Bronte, +13 authors, Lisa H Butterfield.
J Immunother Cancer, 2017 May 19; 5. PMID: 28515944    Free PMC article.
Highly Cited. Review.
ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy.
Hui-Yong Chen, Ze-Zhou Xiao, +3 authors, Shao-Yi Zheng.
Mol Med, 2021 Feb 12; 27(1). PMID: 33568052    Free PMC article.
Long non-coding RNA MIR4435-2HG recruits miR-802 from FLOT2 to promote melanoma progression.
D-M Ma, D Sun, +3 authors, Y-E Han.
Eur Rev Med Pharmacol Sci, 2020 Mar 21; 24(5). PMID: 32196611
Sox11 promotes head and neck cancer progression via the regulation of SDCCAG8.
Junwei Huang, Eoon Hye Ji, +6 authors, Shen Hu.
J Exp Clin Cancer Res, 2019 Mar 30; 38(1). PMID: 30922366    Free PMC article.
The Reversal of Immune Exclusion Mediated by Tadalafil and an Anti-tumor Vaccine Also Induces PDL1 Upregulation in Recurrent Head and Neck Squamous Cell Carcinoma: Interim Analysis of a Phase I Clinical Trial.
Donald T Weed, Serena Zilio, +6 authors, Paolo Serafini.
Front Immunol, 2019 Jun 20; 10. PMID: 31214178    Free PMC article.
Ferroptosis is an autophagic cell death process.
Minghui Gao, Prashant Monian, +3 authors, Xuejun Jiang.
Cell Res, 2016 Aug 16; 26(9). PMID: 27514700    Free PMC article.
Highly Cited.
Tumor-infiltrating dendritic cells in cancer pathogenesis.
Jo Marie Tran Janco, Purushottam Lamichhane, Lavakumar Karyampudi, Keith L Knutson.
J Immunol, 2015 Mar 22; 194(7). PMID: 25795789    Free PMC article.
Highly Cited. Review.
Immune Checkpoint Inhibition in Head and Neck Cancer.
Martin David Forster, Michael-John Devlin.
Front Oncol, 2018 Sep 14; 8. PMID: 30211111    Free PMC article.
Review.
Reassessing the Potential of Myb-targeted Anti-cancer Therapy.
Xiaofeng Liu, Yunxiao Xu, Liping Han, Yan Yi.
J Cancer, 2018 Apr 21; 9(7). PMID: 29675107    Free PMC article.
Review.
Robust enumeration of cell subsets from tissue expression profiles.
Aaron M Newman, Chih Long Liu, +6 authors, Ash A Alizadeh.
Nat Methods, 2015 Mar 31; 12(5). PMID: 25822800    Free PMC article.
Highly Cited.
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.
Cefan Zhou, Changhua Yi, +11 authors, Jingfeng Tang.
Mol Cancer, 2020 Jul 31; 19(1). PMID: 32727463    Free PMC article.
Time-varying covariates and coefficients in Cox regression models.
Zhongheng Zhang, Jaakko Reinikainen, +2 authors, Catharina G M Groothuis-Oudshoorn.
Ann Transl Med, 2018 Jun 30; 6(7). PMID: 29955581    Free PMC article.
Highly Cited.
Mechanism of long noncoding RNAs as transcriptional regulators in cancer.
Yan Huang, Qi Guo, Xi-Ping Ding, Xiangting Wang.
RNA Biol, 2020 Jan 01; 17(11). PMID: 31888402    Free PMC article.
Review.
Development and validation of a fourteen- innate immunity-related gene pairs signature for predicting prognosis head and neck squamous cell carcinoma.
Fujun Zhang, Yu Liu, Yixin Yang, Kai Yang.
BMC Cancer, 2020 Oct 22; 20(1). PMID: 33081731    Free PMC article.
APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.
G Yu, T Boone, +14 authors, L E Theill.
Nat Immunol, 2001 Mar 23; 1(3). PMID: 10973284
LncRNA MIR4435-2HG targets desmoplakin and promotes growth and metastasis of gastric cancer by activating Wnt/β-catenin signaling.
Haiyong Wang, Mengjie Wu, +5 authors, Lisong Teng.
Aging (Albany NY), 2019 Sep 05; 11(17). PMID: 31484163    Free PMC article.
FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations.
Nan Zhou, Jinku Bao.
Database (Oxford), 2020 Mar 29; 2020. PMID: 32219413    Free PMC article.
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Ezra E W Cohen, R Bryan Bell, +16 authors, Robert L Ferris.
J Immunother Cancer, 2019 Jul 17; 7(1). PMID: 31307547    Free PMC article.
Highly Cited.
Visualizing and interpreting cancer genomics data via the Xena platform.
Mary J Goldman, Brian Craft, +9 authors, David Haussler.
Nat Biotechnol, 2020 May 24; 38(6). PMID: 32444850    Free PMC article.
FAM3B promotes progression of oesophageal carcinoma via regulating the AKT-MDM2-p53 signalling axis and the epithelial-mesenchymal transition.
Song-Lin He, Wen-Ping Wang, +3 authors, Long-Qi Chen.
J Cell Mol Med, 2018 Dec 20; 23(2). PMID: 30565387    Free PMC article.
Epidemiologic trends in head and neck cancer and aids in diagnosis.
Nadarajah Vigneswaran, Michelle D Williams.
Oral Maxillofac Surg Clin North Am, 2014 May 06; 26(2). PMID: 24794262    Free PMC article.
Highly Cited. Review.
A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis.
Zuli Wang, Xiaowen Chen, +8 authors, Yongguang Tao.
Mol Ther, 2020 Oct 02; 29(1). PMID: 33002417    Free PMC article.
Long non-coding RNA PTCSC3 inhibits human oral cancer cell proliferation by inducing apoptosis and autophagy.
Hongmei Zhang, Jiang Wang, +3 authors, Xiaoxia Wang.
Arch Med Sci, 2021 Mar 23; 17(2). PMID: 33747284    Free PMC article.
FANCD2 protects against bone marrow injury from ferroptosis.
Xinxin Song, Yangchun Xie, +5 authors, Daolin Tang.
Biochem Biophys Res Commun, 2016 Oct 25; 480(3). PMID: 27773819    Free PMC article.
Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance.
K A Whelan, P M Chandramouleeswaran, +12 authors, H Nakagawa.
Oncogene, 2017 Apr 18; 36(34). PMID: 28414310    Free PMC article.
Identification and validation of potential long non-coding RNA biomarkers in predicting survival of patients with head and neck squamous cell carcinoma.
Junyu Li, Yuehua Li, Xiaoping Wu, Ying Li.
Oncol Lett, 2019 Jun 13; 17(6). PMID: 31186787    Free PMC article.
Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer Therapy.
Ying-Ying Li, Lynn G Feun, +6 authors, Niramol Savaraj.
Int J Mol Sci, 2017 Jun 21; 18(6). PMID: 28629173    Free PMC article.
Review.
Viral CD229 (Ly9) homologs as new manipulators of host immunity.
Ana Angulo, Marta Cuenca, Pablo Martínez-Vicente, Pablo Engel.
J Leukoc Biol, 2019 Feb 23; 105(5). PMID: 30791129
Review.
starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data.
Jun-Hao Li, Shun Liu, +2 authors, Jian-Hua Yang.
Nucleic Acids Res, 2013 Dec 04; 42(Database issue). PMID: 24297251    Free PMC article.
Highly Cited.
The lncRNA MIR4435-2HG is upregulated in hepatocellular carcinoma and promotes cancer cell proliferation by upregulating miRNA-487a.
Qinglei Kong, Caiqian Liang, +4 authors, Jing Zhou.
Cell Mol Biol Lett, 2019 Apr 17; 24. PMID: 30988676    Free PMC article.
Long Non-coding RNA MIR4435-2HG Promotes Colorectal Cancer Proliferation and Metastasis Through miR-206/YAP1 Axis.
Xinhua Dong, Zhen Yang, +2 authors, Xinguang Qiu.
Front Oncol, 2020 Mar 11; 10. PMID: 32154166    Free PMC article.
Lys05 - A Promising Autophagy Inhibitor in the Radiosensitization Battle: Phosphoproteomic Perspective.
Martin Ondrej, Lucie Cechakova, +2 authors, Ales Tichy.
Cancer Genomics Proteomics, 2020 Jun 25; 17(4). PMID: 32576582    Free PMC article.
Methods in mammalian autophagy research.
Noboru Mizushima, Tamotsu Yoshimori, Beth Levine.
Cell, 2010 Feb 11; 140(3). PMID: 20144757    Free PMC article.
Highly Cited.
The Autophagy Database: an all-inclusive information resource on autophagy that provides nourishment for research.
Keiichi Homma, Koji Suzuki, Hideaki Sugawara.
Nucleic Acids Res, 2010 Oct 26; 39(Database issue). PMID: 20972215    Free PMC article.
FKBP8 recruits LC3A to mediate Parkin-independent mitophagy.
Zambarlal Bhujabal, Åsa B Birgisdottir, +6 authors, Terje Johansen.
EMBO Rep, 2017 Apr 07; 18(6). PMID: 28381481    Free PMC article.
Highly Cited.
Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti-tumor immunity.
Lei Shi, Yingqi Liu, Menghuan Li, Zhong Luo.
FEBS J, 2021 May 28;. PMID: 34042258
Review.
Mast cells in breast cancer angiogenesis.
Anca Maria Cimpean, Roberto Tamma, +3 authors, Domenico Ribatti.
Crit Rev Oncol Hematol, 2017 Jun 13; 115. PMID: 28602166
Review.
A role for the immune system in advanced laryngeal cancer.
Marta Tagliabue, Fausto Maffini, +18 authors, Mohssen Ansarin.
Sci Rep, 2020 Oct 29; 10(1). PMID: 33110100    Free PMC article.
Comprehensive analysis of ceRNA networks reveals prognostic lncRNAs related to immune infiltration in colorectal cancer.
Jingyi Chen, Yuxuan Song, +7 authors, Weidong Yu.
BMC Cancer, 2021 Mar 23; 21(1). PMID: 33750326    Free PMC article.
Tumor heterogeneity in autophagy-dependent ferroptosis.
Jingbo Li, Jiao Liu, +8 authors, Daolin Tang.
Autophagy, 2021 Jan 07; 17(11). PMID: 33404288    Free PMC article.
American Cancer Society Head and Neck Cancer Survivorship Care Guideline.
Ezra E W Cohen, Samuel J LaMonte, +9 authors, Mandi L Pratt-Chapman.
CA Cancer J Clin, 2016 Mar 24; 66(3). PMID: 27002678
Highly Cited. Systematic Review.
Ferroptosis: process and function.
Y Xie, W Hou, +5 authors, D Tang.
Cell Death Differ, 2016 Jan 23; 23(3). PMID: 26794443    Free PMC article.
Highly Cited. Review.
miRNAs and lncRNAs as Novel Therapeutic Targets to Improve Cancer Immunotherapy.
Maria Teresa Di Martino, Caterina Riillo, +6 authors, Pierfrancesco Tassone.
Cancers (Basel), 2021 Apr 04; 13(7). PMID: 33808190    Free PMC article.
Review.
Self-eating and self-killing: crosstalk between autophagy and apoptosis.
M Chiara Maiuri, Einat Zalckvar, Adi Kimchi, Guido Kroemer.
Nat Rev Mol Cell Biol, 2007 Aug 25; 8(9). PMID: 17717517
Highly Cited. Review.
The novel KLF4/PLAC8 signaling pathway regulates lung cancer growth.
Yunlu Jia, Xiaogang Ying, +6 authors, Linbo Wang.
Cell Death Dis, 2018 May 24; 9(6). PMID: 29789534    Free PMC article.
Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer.
Jong-Lyel Roh, Eun Hye Kim, +2 authors, Daiha Shin.
Cancer Lett, 2016 Aug 02; 381(1). PMID: 27477897
Modulation of T cell cytokine production by interferon regulatory factor-4.
Chuan-Min Hu, So Young Jang, Jessica C Fanzo, Alessandra B Pernis.
J Biol Chem, 2002 Oct 11; 277(51). PMID: 12374808
Insulin-like growth factor 1 receptor-mediated cell survival in hypoxia depends on the promotion of autophagy via suppression of the PI3K/Akt/mTOR signaling pathway.
Qi Liu, Jing-Zhi Guan, +4 authors, Yong Liu.
Mol Med Rep, 2017 Mar 06; 15(4). PMID: 28260056    Free PMC article.
ImmuCellAI: A Unique Method for Comprehensive T-Cell Subsets Abundance Prediction and its Application in Cancer Immunotherapy.
Ya-Ru Miao, Qiong Zhang, +4 authors, An-Yuan Guo.
Adv Sci (Weinh), 2020 Apr 11; 7(7). PMID: 32274301    Free PMC article.
The therapeutic promise of disrupting the PD-1/PD-L1 immune checkpoint in cancer: unleashing the CD8 T cell mediated anti-tumor activity results in significant, unprecedented clinical efficacy in various solid tumors.
Emanuela Romano, Pedro Romero.
J Immunother Cancer, 2015 Apr 23; 3. PMID: 25901287    Free PMC article.
The crosstalk between autophagy and ferroptosis: what can we learn to target drug resistance in cancer?
Yulu Zhou, Yong Shen, +4 authors, Jichun Zhou.
Cancer Biol Med, 2020 Jan 08; 16(4). PMID: 31908884    Free PMC article.
RNAct: Protein-RNA interaction predictions for model organisms with supporting experimental data.
Benjamin Lang, Alexandros Armaos, Gian G Tartaglia.
Nucleic Acids Res, 2018 Nov 18; 47(D1). PMID: 30445601    Free PMC article.
Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export.
Caitlin W Brown, John J Amante, +6 authors, Arthur M Mercurio.
Dev Cell, 2019 Nov 19; 51(5). PMID: 31735663    Free PMC article.
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells.
Taichi Hara, Akito Takamura, +4 authors, Noboru Mizushima.
J Cell Biol, 2008 Apr 30; 181(3). PMID: 18443221    Free PMC article.
Highly Cited.
Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity.
Bassam Janji, Guy Berchem, Salem Chouaib.
Front Immunol, 2018 Jun 21; 9. PMID: 29922284    Free PMC article.
Review.
Long non‑coding RNA PCED1B‑AS1 promotes pancreatic ductal adenocarcinoma progression by regulating the miR‑411‑3p/HIF‑1α axis.
Yi Zhang, Huan Ma, Chang Chen.
Oncol Rep, 2021 May 27; 46(1). PMID: 34036383    Free PMC article.
Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma.
Daniel Peña-Oyarzún, Montserrat Reyes, +6 authors, Alfredo Criollo.
Front Oncol, 2020 Dec 29; 10. PMID: 33363032    Free PMC article.
Review.
Inhibition of Glutaredoxin 5 predisposes Cisplatin-resistant Head and Neck Cancer Cells to Ferroptosis.
Jaewang Lee, Ji Hyeon You, Daiha Shin, Jong-Lyel Roh.
Theranostics, 2020 Jul 21; 10(17). PMID: 32685019    Free PMC article.
Identification of CD112R as a novel checkpoint for human T cells.
Yuwen Zhu, Alessandro Paniccia, +6 authors, Barish H Edil.
J Exp Med, 2016 Jan 13; 213(2). PMID: 26755705    Free PMC article.
The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11.
Tong Liu, Le Jiang, Omid Tavana, Wei Gu.
Cancer Res, 2019 Feb 03; 79(8). PMID: 30709928    Free PMC article.
Highly Cited.
Mast cells: A double-edged sword in cancer.
Afshin Derakhshani, Fatemeh Vahidian, +3 authors, Behzad Baradaran.
Immunol Lett, 2019 Mar 25; 209. PMID: 30905824
Review.
Targeting Ferroptosis to Iron Out Cancer.
Behrouz Hassannia, Peter Vandenabeele, Tom Vanden Berghe.
Cancer Cell, 2019 May 21; 35(6). PMID: 31105042
Highly Cited. Review.
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.
Vasanthi S Viswanathan, Matthew J Ryan, +37 authors, Stuart L Schreiber.
Nature, 2017 Jul 06; 547(7664). PMID: 28678785    Free PMC article.
Highly Cited.
HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer.
Mark Kalisz, Edgar Bernardo, +16 authors, Jorge Ferrer.
EMBO J, 2020 Mar 11; 39(9). PMID: 32154941    Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Induction of Plac8 promotes pro-survival function of autophagy in cadmium-induced prostate carcinogenesis.
Venkatesh Kolluru, Deeksha Pal, +3 authors, Chendil Damodaran.
Cancer Lett, 2017 Aug 29; 408. PMID: 28844710    Free PMC article.
Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation.
Madhumouli Chatterjee, Thomas Rauen, +4 authors, George C Tsokos.
J Immunol, 2011 Dec 21; 188(3). PMID: 22184727    Free PMC article.
A travel guide to Cytoscape plugins.
Rintaro Saito, Michael E Smoot, +6 authors, Trey Ideker.
Nat Methods, 2012 Nov 08; 9(11). PMID: 23132118    Free PMC article.
Highly Cited.
LncRNA MIR4435-2HG potentiates the proliferation and invasion of glioblastoma cells via modulating miR-1224-5p/TGFBR2 axis.
Hongchao Xu, Beilin Zhang, +5 authors, Jie Mao.
J Cell Mol Med, 2020 Apr 23; 24(11). PMID: 32319715    Free PMC article.
Correlation Coefficients: Appropriate Use and Interpretation.
Patrick Schober, Christa Boer, Lothar A Schwarte.
Anesth Analg, 2018 Feb 27; 126(5). PMID: 29481436
Highly Cited. Review.
Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein.
Enyong Dai, Leng Han, +7 authors, Daolin Tang.
Autophagy, 2020 Jan 11; 16(11). PMID: 31920150    Free PMC article.
Alterations of oncogenes expression in NK cells in patients with cancer.
Gulnur K Zakiryanova, Elena Kustova, +4 authors, Michael R Shurin.
Immun Inflamm Dis, 2017 Jul 12; 5(4). PMID: 28695716    Free PMC article.
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Freddie Bray, Jacques Ferlay, +3 authors, Ahmedin Jemal.
CA Cancer J Clin, 2018 Sep 13; 68(6). PMID: 30207593
Highly Cited.
Autophagy-Dependent Ferroptosis: Machinery and Regulation.
Jiao Liu, Feimei Kuang, +3 authors, Daolin Tang.
Cell Chem Biol, 2020 Mar 12; 27(4). PMID: 32160513    Free PMC article.
Review.
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Lorenzo Galluzzi, Ilio Vitale, +166 authors, Guido Kroemer.
Cell Death Differ, 2018 Jan 25; 25(3). PMID: 29362479    Free PMC article.
Highly Cited. Review.
Placenta Specific 8 Suppresses IL-18 Production through Regulation of Autophagy and Is Associated with Adult Still Disease.
Seiji Segawa, Yuya Kondo, +8 authors, Takayuki Sumida.
J Immunol, 2018 Nov 09; 201(12). PMID: 30404814
Prognostic significance of an autophagy-related long non-coding RNA signature in patients with oral and oropharyngeal squamous cell carcinoma.
Qingkun Jiang, Danfeng Xue, Fanzhe Shi, Jiaxuan Qiu.
Oncol Lett, 2020 Nov 27; 21(1). PMID: 33240435    Free PMC article.
Ferroptosis: past, present and future.
Jie Li, Feng Cao, +5 authors, Gang Wang.
Cell Death Dis, 2020 Feb 06; 11(2). PMID: 32015325    Free PMC article.
Review.
Inferring tumour purity and stromal and immune cell admixture from expression data.
Kosuke Yoshihara, Maria Shahmoradgoli, +12 authors, Roel G W Verhaak.
Nat Commun, 2013 Oct 12; 4. PMID: 24113773    Free PMC article.
Highly Cited.
The relationship between autophagy and the immune system and its applications for tumor immunotherapy.
Guan-Min Jiang, Yuan Tan, +7 authors, Hong Shan.
Mol Cancer, 2019 Jan 27; 18(1). PMID: 30678689    Free PMC article.
Highly Cited. Review.
TBX21 predicts prognosis of patients and drives cancer stem cell maintenance via the TBX21-IL-4 pathway in lung adenocarcinoma.
Shuangtao Zhao, Wenzhi Shen, Jiangyong Yu, Luhua Wang.
Stem Cell Res Ther, 2018 Apr 05; 9(1). PMID: 29615105    Free PMC article.
Metabolic Regulation of Macrophage Polarization in Cancer.
Kamiya Mehla, Pankaj K Singh.
Trends Cancer, 2019 Dec 10; 5(12). PMID: 31813459    Free PMC article.
Review.
STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy.
Jin-Fei Chen, Peng Wu, +6 authors, Fen Yang.
Mol Cancer, 2018 Jan 14; 17(1). PMID: 29329543    Free PMC article.
Highly Cited.
Autophagy promotes ferroptosis by degradation of ferritin.
Wen Hou, Yangchun Xie, +5 authors, Daolin Tang.
Autophagy, 2016 Jun 02; 12(8). PMID: 27245739    Free PMC article.
Highly Cited.
HAMdb: a database of human autophagy modulators with specific pathway and disease information.
Ning-Ning Wang, Jie Dong, +5 authors, Dong-Sheng Cao.
J Cheminform, 2018 Aug 02; 10(1). PMID: 30066211    Free PMC article.
Ferroptosis: an iron-dependent form of nonapoptotic cell death.
Scott J Dixon, Kathryn M Lemberg, +9 authors, Brent R Stockwell.
Cell, 2012 May 29; 149(5). PMID: 22632970    Free PMC article.
Highly Cited.
Current Approaches to Engineering of NK Cells for Cancer Immunotherapy.
M A Streltsova, E V Barsov, +2 authors, E I Kovalenko.
Curr Pharm Des, 2018 Aug 30; 24(24). PMID: 30156154
Review.
Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients.
Alice O Kamphorst, Rathi N Pillai, +16 authors, Suresh S Ramalingam.
Proc Natl Acad Sci U S A, 2017 Apr 28; 114(19). PMID: 28446615    Free PMC article.
Highly Cited.
Molecular mechanisms of ferroptosis and its role in cancer therapy.
Tao Xu, Wei Ding, +4 authors, Jianxun Wang.
J Cell Mol Med, 2019 Jun 25; 23(8). PMID: 31232522    Free PMC article.
Review.
Ferroptosis-Related Long Non-Coding RNA Signature Contributes to the Prediction of Prognosis Outcomes in Head and Neck Squamous Cell Carcinomas.
Wenru Jiang, Yingtao Song, +2 authors, Xiaofei Meng.
Front Genet, 2022 Jan 04; 12. PMID: 34976018    Free PMC article.
Regulation of Ferroptosis by Non-Coding RNAs in Head and Neck Cancers.
Pei-Ling Hsieh, Shih-Chi Chao, Pei-Ming Chu, Cheng-Chia Yu.
Int J Mol Sci, 2022 Mar 26; 23(6). PMID: 35328568    Free PMC article.
Review.