. 2021 Sep; 13(18):.
doi: 10.3390/cancers13184543.

NSCLC Biomarkers to Predict Response to Immunotherapy with Checkpoint Inhibitors (ICI): From the Cells to In Vivo Images

Virginia Liberini 1 Annapaola Mariniello 2 Luisella Righi 3 Martina Capozza 4 Marco Donatello Delcuratolo 2 Enzo Terreno 4 Mohsen Farsad 5 Marco Volante 3 Silvia Novello 2 Désirée Deandreis 1 
  • PMID: 34572771
  •     192 References
  •     2 citations


Lung cancer remains the leading cause of cancer-related death, and it is usually diagnosed in advanced stages (stage III or IV). Recently, the availability of targeted strategies and of immunotherapy with checkpoint inhibitors (ICI) has favorably changed patient prognosis. Treatment outcome is closely related to tumor biology and interaction with the tumor immune microenvironment (TME). While the response in molecular targeted therapies relies on the presence of specific genetic alterations in tumor cells, accurate ICI biomarkers of response are lacking, and clinical outcome likely depends on multiple factors that are both host and tumor-related. This paper is an overview of the ongoing research on predictive factors both from in vitro/ex vivo analysis (ranging from conventional pathology to molecular biology) and in vivo analysis, where molecular imaging is showing an exponential growth and use due to technological advancements and to the new bioinformatics approaches applied to image analyses that allow the recovery of specific features in specific tumor subclones.

Keywords: PD-1; PD-L1; PET/CT; immune PET; immune checkpoint inhibitors; immunotherapy; non-small cell lung carcinoma; radiomics.

PET imaging of immune checkpoint proteins in oncology.
Alizée Bouleau, Vincent Lebon, Charles Truillet.
Pharmacol Ther, 2020 Dec 12; 222. PMID: 33307142
Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
Dai Fukumura, Jonas Kloepper, +2 authors, Rakesh K Jain.
Nat Rev Clin Oncol, 2018 Mar 07; 15(5). PMID: 29508855    Free PMC article.
Highly Cited. Review.
Will FAPI PET/CT Replace FDG PET/CT in the Next Decade? Counterpoint-No, Not So Fast!
Farshad Moradi, Andrei Iagaru.
AJR Am J Roentgenol, 2020 Aug 07; 216(2). PMID: 32755204
Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC.
Mark A Socinski, Robert M Jotte, +18 authors, IMpower150 Study Group.
N Engl J Med, 2018 Jun 05; 378(24). PMID: 29863955
Highly Cited.
Epigenetic alterations are associated with tumor mutation burden in non-small cell lung cancer.
Liangliang Cai, Hua Bai, +13 authors, Jie Wang.
J Immunother Cancer, 2019 Jul 28; 7(1). PMID: 31349879    Free PMC article.
Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma.
Zhong-Yi Dong, Wen-Zhao Zhong, +16 authors, Yi-Long Wu.
Clin Cancer Res, 2017 Jan 01; 23(12). PMID: 28039262
Highly Cited.
Value of 18F-FDG-PET to predict PD-L1 expression and outcomes of PD-1 inhibition therapy in human cancers.
Kyoichi Kaira, Ichiei Kuji, Hiroshi Kagamu.
Cancer Imaging, 2021 Jan 15; 21(1). PMID: 33441183    Free PMC article.
Angiopoietin-2 as a Biomarker and Target for Immune Checkpoint Therapy.
Xinqi Wu, Anita Giobbie-Hurder, +15 authors, F Stephen Hodi.
Cancer Immunol Res, 2016 Dec 23; 5(1). PMID: 28003187    Free PMC article.
Topography of cancer-associated immune cells in human solid tumors.
Jakob Nikolas Kather, Meggy Suarez-Carmona, +17 authors, Niels Halama.
Elife, 2018 Sep 05; 7. PMID: 30179157    Free PMC article.
Highly Cited.
Safety of Fibroblast Activation Protein-Targeted Radionuclide Therapy by a Low-Dose Dosimetric Approach Using 177Lu-FAPI04.
Serkan Kuyumcu, Bilal Kovan, +6 authors, Cuneyt Turkmen.
Clin Nucl Med, 2021 Apr 23; 46(8). PMID: 33883494
CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions.
Masao Hashimoto, Alice O Kamphorst, +5 authors, Rafi Ahmed.
Annu Rev Med, 2018 Feb 08; 69. PMID: 29414259
Highly Cited. Review.
Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registry.
J Mazieres, A Drilon, +35 authors, O Gautschi.
Ann Oncol, 2019 May 28; 30(8). PMID: 31125062    Free PMC article.
Highly Cited.
Association between immunotherapy biomarkers and glucose metabolism from F-18 FDG PET.
B S Kim, J Kang, +5 authors, Y H Kim.
Eur Rev Med Pharmacol Sci, 2020 Sep 08; 24(16). PMID: 32894535
Restoring function in exhausted CD8 T cells during chronic viral infection.
Daniel L Barber, E John Wherry, +5 authors, Rafi Ahmed.
Nature, 2005 Dec 31; 439(7077). PMID: 16382236
Highly Cited.
The First-week Proliferative Response of Peripheral Blood PD-1+CD8+ T Cells Predicts the Response to Anti-PD-1 Therapy in Solid Tumors.
Kyung Hwan Kim, Jinhyun Cho, +10 authors, Eui-Cheol Shin.
Clin Cancer Res, 2019 Jan 17; 25(7). PMID: 30647082
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.
Yuhui Huang, Jianping Yuan, +14 authors, Mark C Poznansky.
Proc Natl Acad Sci U S A, 2012 Oct 10; 109(43). PMID: 23045683    Free PMC article.
Highly Cited.
Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab.
Nadeem Riaz, Jonathan J Havel, +22 authors, Timothy A Chan.
Cell, 2017 Oct 17; 171(4). PMID: 29033130    Free PMC article.
Highly Cited.
Artificial Intelligence in PET/CT Is about to Make Whole-Body Tumor Burden Measurements a Clinical Reality.
Jerry W Froelich, Ali Salavati.
Radiology, 2019 Dec 12; 294(2). PMID: 31825291
STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma.
Ferdinandos Skoulidis, Michael E Goldberg, +66 authors, John V Heymach.
Cancer Discov, 2018 May 19; 8(7). PMID: 29773717    Free PMC article.
Highly Cited.
EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non-Small Cell Lung Cancer: A Retrospective Analysis.
Justin F Gainor, Alice T Shaw, +18 authors, Mari Mino-Kenudson.
Clin Cancer Res, 2016 May 27; 22(18). PMID: 27225694    Free PMC article.
Highly Cited.
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.
Naiyer A Rizvi, Matthew D Hellmann, +21 authors, Timothy A Chan.
Science, 2015 Mar 15; 348(6230). PMID: 25765070    Free PMC article.
Highly Cited.
Association of the Lung Immune Prognostic Index With Immune Checkpoint Inhibitor Outcomes in Patients With Advanced Non-Small Cell Lung Cancer.
Laura Mezquita, Edouard Auclin, +19 authors, Benjamin Besse.
JAMA Oncol, 2018 Jan 13; 4(3). PMID: 29327044    Free PMC article.
Highly Cited.
STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.
Shohei Koyama, Esra A Akbay, +30 authors, Kwok-Kin Wong.
Cancer Res, 2016 Feb 03; 76(5). PMID: 26833127    Free PMC article.
Highly Cited.
Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.
Frank A Schildberg, Sarah R Klein, Gordon J Freeman, Arlene H Sharpe.
Immunity, 2016 May 19; 44(5). PMID: 27192563    Free PMC article.
Highly Cited. Review.
Immune-Modified Response Evaluation Criteria In Solid Tumors (imRECIST): Refining Guidelines to Assess the Clinical Benefit of Cancer Immunotherapy.
F Stephen Hodi, Marcus Ballinger, +13 authors, Jedd D Wolchok.
J Clin Oncol, 2018 Jan 18; 36(9). PMID: 29341833
Highly Cited.
18FDG PET/CT in the early assessment of non-small cell lung cancer response to immunotherapy: frequency and clinical significance of atypical evolutive patterns.
O Humbert, N Cadour, +13 authors, J Otto.
Eur J Nucl Med Mol Imaging, 2019 Nov 25; 47(5). PMID: 31760467
Multiomics Prediction of Response Rates to Therapies to Inhibit Programmed Cell Death 1 and Programmed Cell Death 1 Ligand 1.
Joo Sang Lee, Eytan Ruppin.
JAMA Oncol, 2019 Aug 23; 5(11). PMID: 31436822    Free PMC article.
Highly Cited.
Ways to enhance lymphocyte trafficking into tumors and fitness of tumor infiltrating lymphocytes.
Matteo Bellone, Arianna Calcinotto.
Front Oncol, 2013 Sep 26; 3. PMID: 24062984    Free PMC article.
Clinicopathological and genomic correlates of programmed cell death ligand 1 (PD-L1) expression in nonsquamous non-small-cell lung cancer.
G Lamberti, L F Spurr, +8 authors, M M Awad.
Ann Oncol, 2020 Mar 17; 31(6). PMID: 32171752
A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts.
Anastasia Loktev, Thomas Lindner, +8 authors, Uwe Haberkorn.
J Nucl Med, 2018 Apr 08; 59(9). PMID: 29626120    Free PMC article.
New PET technologies - embracing progress and pushing the limits.
Nicolas Aide, Charline Lasnon, +8 authors, Daniel R McGowan.
Eur J Nucl Med Mol Imaging, 2021 Jun 04; 48(9). PMID: 34081153    Free PMC article.
Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells.
Mark J Selby, John J Engelhardt, +4 authors, Alan J Korman.
Cancer Immunol Res, 2014 Apr 30; 1(1). PMID: 24777248
Highly Cited.
State-of-the-art of FAPI-PET imaging: a systematic review and meta-analysis.
Martina Sollini, Margarita Kirienko, +3 authors, Arturo Chiti.
Eur J Nucl Med Mol Imaging, 2021 Jun 27; 48(13). PMID: 34173007
Systematic Review.
Roles of the immune system in cancer: from tumor initiation to metastatic progression.
Hugo Gonzalez, Catharina Hagerling, Zena Werb.
Genes Dev, 2018 Oct 03; 32(19-20). PMID: 30275043    Free PMC article.
Highly Cited. Review.
Myeloid-derived suppressor cells predict survival of patients with advanced melanoma: comparison with regulatory T cells and NY-ESO-1- or melan-A-specific T cells.
Benjamin Weide, Alexander Martens, +10 authors, Graham Pawelec.
Clin Cancer Res, 2013 Dec 11; 20(6). PMID: 24323899
Highly Cited.
Good clinical practice recommendations for the use of PET/CT in oncology.
Pierre-Yves Salaün, Ronan Abgral, +23 authors, Florent Cachin.
Eur J Nucl Med Mol Imaging, 2019 Oct 23; 47(1). PMID: 31637482
Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F] FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer.
Haojun Chen, Yizhen Pang, +12 authors, Hua Wu.
Eur J Nucl Med Mol Imaging, 2020 Mar 31; 47(8). PMID: 32222810
Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition.
Kevin Litchfield, James L Reading, +25 authors, Charles Swanton.
Cell, 2021 Jan 29; 184(3). PMID: 33508232    Free PMC article.
Mechanisms and clinical implications of tumor heterogeneity and convergence on recurrent phenotypes.
Jasmine A McQuerry, Jeffrey T Chang, +2 authors, Andrea H Bild.
J Mol Med (Berl), 2017 Sep 06; 95(11). PMID: 28871446    Free PMC article.
Positron Emission Tomography-Based Response to Target and Immunotherapies in Oncology.
Maria Isabella Donegani, Giulia Ferrarazzo, +4 authors, Silvia Morbelli.
Medicina (Kaunas), 2020 Jul 30; 56(8). PMID: 32722205    Free PMC article.
Neoadjuvant PD-1 Blockade in Resectable Lung Cancer.
Patrick M Forde, Jamie E Chaft, +32 authors, Drew M Pardoll.
N Engl J Med, 2018 Apr 17; 378(21). PMID: 29658848    Free PMC article.
Highly Cited.
[18F]FDG PET immunotherapy radiomics signature (iRADIOMICS) predicts response of non-small-cell lung cancer patients treated with pembrolizumab.
Damijan Valentinuzzi, Martina Vrankar, +9 authors, Robert Jeraj.
Radiol Oncol, 2020 Jul 30; 54(3). PMID: 32726293    Free PMC article.
Integrating radiomics into holomics for personalised oncology: from algorithms to bedside.
Roberto Gatta, Adrien Depeursinge, +2 authors, Antoine Leimgruber.
Eur Radiol Exp, 2020 Feb 09; 4(1). PMID: 32034573    Free PMC article.
Metabolic tumor burden predicts for disease progression and death in lung cancer.
Percy Lee, Dilani K Weerasuriya, +8 authors, Billy W Loo.
Int J Radiat Oncol Biol Phys, 2007 Sep 18; 69(2). PMID: 17869659
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy.
Janis M Taube, Alison Klein, +7 authors, Robert A Anders.
Clin Cancer Res, 2014 Apr 10; 20(19). PMID: 24714771    Free PMC article.
Highly Cited.
18F-FDG Pet Parameters and Radiomics Features Analysis in Advanced Nsclc Treated with Immunotherapy as Predictors of Therapy Response and Survival.
Giulia Polverari, Francesco Ceci, +11 authors, Désirée Deandreis.
Cancers (Basel), 2020 May 10; 12(5). PMID: 32380754    Free PMC article.
Targeted agents and immunotherapies: optimizing outcomes in melanoma.
Jason J Luke, Keith T Flaherty, Antoni Ribas, Georgina V Long.
Nat Rev Clin Oncol, 2017 Apr 05; 14(8). PMID: 28374786
Highly Cited. Review.
The Warburg Effect: How Does it Benefit Cancer Cells?
Maria V Liberti, Jason W Locasale.
Trends Biochem Sci, 2016 Jan 19; 41(3). PMID: 26778478    Free PMC article.
Highly Cited. Review.
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Frederick Arce Vargas, Andrew J S Furness, +32 authors, Sergio A Quezada.
Cancer Cell, 2018 Mar 27; 33(4). PMID: 29576375    Free PMC article.
Highly Cited.
Targeting the PD-1/PD-L1 Immune Checkpoint in EGFR-Mutated or ALK-Translocated Non-Small-Cell Lung Cancer.
Olivier Bylicki, Nicolas Paleiron, +6 authors, Christos Chouaid.
Target Oncol, 2017 Jun 19; 12(5). PMID: 28624922
Modern radiopharmaceuticals for lung cancer imaging with positron emission tomography/computed tomography scan: A systematic review.
Athanasios S Theodoropoulos, Ioannis Gkiozos, +4 authors, Maria Tolia.
SAGE Open Med, 2020 Oct 17; 8. PMID: 33062275    Free PMC article.
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L Topalian, F Stephen Hodi, +27 authors, Mario Sznol.
N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658127    Free PMC article.
Highly Cited.
Prognostic and diagnostic value of [18F]FDG-PET/CT in restaging patients with small cell lung carcinoma: an Italian multicenter study.
Natale Quartuccio, Laura Evangelista, +28 authors, Young AIMN Working Group.
Nucl Med Commun, 2019 May 29; 40(8). PMID: 31136534
Value of pre-therapy 18F-FDG PET/CT radiomics in predicting EGFR mutation status in patients with non-small cell lung cancer.
Jianyuan Zhang, Xinming Zhao, +6 authors, Jingya Han.
Eur J Nucl Med Mol Imaging, 2019 Nov 16; 47(5). PMID: 31728587
The immune response-related mutational signatures and driver genes in non-small-cell lung cancer.
Hao Chen, Wei Chong, +3 authors, Xue Li.
Cancer Sci, 2019 Jun 22; 110(8). PMID: 31222843    Free PMC article.
Regulation and Function of the PD-L1 Checkpoint.
Chong Sun, Riccardo Mezzadra, Ton N Schumacher.
Immunity, 2018 Mar 22; 48(3). PMID: 29562194    Free PMC article.
Highly Cited. Review.
Theranostics Targeting Fibroblast Activation Protein in the Tumor Stroma: 64Cu- and 225Ac-Labeled FAPI-04 in Pancreatic Cancer Xenograft Mouse Models.
Tadashi Watabe, Yuwei Liu, +11 authors, Jun Hatazawa.
J Nucl Med, 2019 Oct 06; 61(4). PMID: 31586001    Free PMC article.
Clinical and molecular correlates of PD-L1 expression in patients with lung adenocarcinomas.
A J Schoenfeld, H Rizvi, +15 authors, M D Hellmann.
Ann Oncol, 2020 Mar 18; 31(5). PMID: 32178965    Free PMC article.
Metabolic tumor volume is an independent prognostic factor in patients treated definitively for non-small-cell lung cancer.
Percy Lee, Jose G Bazan, +6 authors, Billy W Loo.
Clin Lung Cancer, 2011 Jun 28; 13(1). PMID: 21703935    Free PMC article.
18F-FDG PET/CT for Monitoring of Ipilimumab Therapy in Patients with Metastatic Melanoma.
Kimiteru Ito, Rebecca Teng, +7 authors, Wolfgang A Weber.
J Nucl Med, 2018 Nov 11; 60(3). PMID: 30413661    Free PMC article.
FDG PET/CT for assessing tumour response to immunotherapy : Report on the EANM symposium on immune modulation and recent review of the literature.
Nicolas Aide, Rodney J Hicks, +3 authors, Egesta Lopci.
Eur J Nucl Med Mol Imaging, 2018 Oct 07; 46(1). PMID: 30291373    Free PMC article.
Highly Cited. Review.
Definition, Incidence, and Challenges for Assessment of Hyperprogressive Disease During Cancer Treatment With Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis.
Hyo Jung Park, Kyung Won Kim, +4 authors, Nikhil H Ramaiya.
JAMA Netw Open, 2021 Mar 25; 4(3). PMID: 33760090    Free PMC article.
Systematic Review.
Predicting EGFR mutation subtypes in lung adenocarcinoma using 18F-FDG PET/CT radiomic features.
Qiufang Liu, Dazhen Sun, +5 authors, Shaoli Song.
Transl Lung Cancer Res, 2020 Jul 18; 9(3). PMID: 32676319    Free PMC article.
High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy.
Carsten Krieg, Malgorzata Nowicka, +7 authors, Burkhard Becher.
Nat Med, 2018 Jan 09; 24(2). PMID: 29309059
Highly Cited.
Role of FDG PET/CT in the Eighth Edition of TNM Staging of Non-Small Cell Lung Cancer.
Asha Kandathil, Fernando U Kay, +2 authors, Rathan M Subramaniam.
Radiographics, 2018 Nov 14; 38(7). PMID: 30422775
Patterns of responses in metastatic NSCLC during PD-1 or PDL-1 inhibitor therapy: Comparison of RECIST 1.1, irRECIST and iRECIST criteria.
M Tazdait, L Mezquita, +10 authors, C Caramella.
Eur J Cancer, 2017 Nov 29; 88. PMID: 29182990
Highly Cited.
T cell receptor repertoire features associated with survival in immunotherapy-treated pancreatic ductal adenocarcinoma.
Alexander C Hopkins, Mark Yarchoan, +7 authors, Elizabeth M Jaffee.
JCI Insight, 2018 Jul 13; 3(13). PMID: 29997287    Free PMC article.
Highly Cited.
Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer.
A N Niemeijer, D Leung, +20 authors, A J de Langen.
Nat Commun, 2018 Nov 09; 9(1). PMID: 30405135    Free PMC article.
Highly Cited.
Fibroblasts Influence the Efficacy, Resistance, and Future Use of Vaccines and Immunotherapy in Cancer Treatment.
Bailee H Sliker, Paul M Campbell.
Vaccines (Basel), 2021 Jul 03; 9(6). PMID: 34200702    Free PMC article.
Pilot study of (89)Zr-bevacizumab positron emission tomography in patients with advanced non-small cell lung cancer.
Idris Bahce, Marc C Huisman, +6 authors, Egbert F Smit.
EJNMMI Res, 2015 Jun 10; 4(1). PMID: 26055936    Free PMC article.
The biology and management of non-small cell lung cancer.
Roy S Herbst, Daniel Morgensztern, Chris Boshoff.
Nature, 2018 Jan 25; 553(7689). PMID: 29364287
Highly Cited. Review.
Correlation of metabolic information on FDG-PET with tissue expression of immune markers in patients with non-small cell lung cancer (NSCLC) who are candidates for upfront surgery.
Egesta Lopci, Luca Toschi, +13 authors, Arturo Chiti.
Eur J Nucl Med Mol Imaging, 2016 Jun 03; 43(11). PMID: 27251642
The immune contexture in cancer prognosis and treatment.
Wolf H Fridman, Laurence Zitvogel, Catherine Sautès-Fridman, Guido Kroemer.
Nat Rev Clin Oncol, 2017 Jul 26; 14(12). PMID: 28741618
Highly Cited. Review.
Management of non-small-cell lung cancer: recent developments.
Martin Reck, David F Heigener, +2 authors, Klaus F Rabe.
Lancet, 2013 Aug 27; 382(9893). PMID: 23972814
Highly Cited. Review.
Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab.
N Chaput, P Lepage, +15 authors, F Carbonnel.
Ann Oncol, 2017 Apr 04; 28(6). PMID: 28368458
Highly Cited.
PD-1 blockade induces responses by inhibiting adaptive immune resistance.
Paul C Tumeh, Christina L Harview, +23 authors, Antoni Ribas.
Nature, 2014 Nov 28; 515(7528). PMID: 25428505    Free PMC article.
Highly Cited.
From RECIST to PERCIST: Evolving Considerations for PET response criteria in solid tumors.
Richard L Wahl, Heather Jacene, Yvette Kasamon, Martin A Lodge.
J Nucl Med, 2009 Jun 24; 50 Suppl 1. PMID: 19403881    Free PMC article.
Highly Cited. Review.
Integrating Imaging, Histologic, and Genetic Features to Predict Tumor Mutation Burden of Non-Small-Cell Lung Cancer.
Nasha Zhang, Jia Wu, +3 authors, Ruijiang Li.
Clin Lung Cancer, 2019 Nov 18; 21(3). PMID: 31734072
Metabolic Parameters as Biomarkers of Response to Immunotherapy and Prognosis in Non-Small Cell Lung Cancer (NSCLC): A Real World Experience.
Lavinia Monaco, Maria Gemelli, +10 authors, Luca Guerra.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33915801    Free PMC article.
Favorable outcome of patients with lung adenocarcinoma harboring POLE mutations and expressing high PD-L1.
Liang Liu, Jimmy Ruiz, +7 authors, Wei Zhang.
Mol Cancer, 2018 Apr 14; 17(1). PMID: 29650000    Free PMC article.
Baseline Plasma Tumor Mutation Burden Predicts Response to Pembrolizumab-based Therapy in Patients with Metastatic Non-Small Cell Lung Cancer.
Charu Aggarwal, Jeffrey C Thompson, +18 authors, Erica L Carpenter.
Clin Cancer Res, 2020 Feb 28; 26(10). PMID: 32102950    Free PMC article.
Changes in serum interleukin-8 (IL-8) levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small-cell lung cancer patients.
M F Sanmamed, J L Perez-Gracia, +17 authors, I Melero.
Ann Oncol, 2017 Jun 09; 28(8). PMID: 28595336    Free PMC article.
Highly Cited.
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.
Roy S Herbst, Jean-Charles Soria, +19 authors, F Stephen Hodi.
Nature, 2014 Nov 28; 515(7528). PMID: 25428504    Free PMC article.
Highly Cited.
Antiangiogenic therapy and immune checkpoint blockade go hand in hand.
Luis Felipe Campesato, Taha Merghoub.
Ann Transl Med, 2018 Jan 05; 5(24). PMID: 29299458    Free PMC article.
Reassessing Patterns of Response to Immunotherapy with PET: From Morphology to Metabolism.
Larissa B Costa, Marcelo A Queiroz, +7 authors, Carlos A Buchpiguel.
Radiographics, 2020 Dec 05; 41(1). PMID: 33275541
Population biology of antigen presentation by MHC class I molecules.
P Parham, T Ohta.
Science, 1996 Apr 05; 272(5258). PMID: 8600539
Highly Cited. Review.
A Systematic Review of PET Textural Analysis and Radiomics in Cancer.
Manuel Piñeiro-Fiel, Alexis Moscoso, +3 authors, Pablo Aguiar.
Diagnostics (Basel), 2021 Mar 07; 11(2). PMID: 33672285    Free PMC article.
Fully-automated synthesis of 177Lu labelled FAPI derivatives on the module modular lab-Eazy.
Kurtulus Eryilmaz, Benan Kilbas.
EJNMMI Radiopharm Chem, 2021 Apr 18; 6(1). PMID: 33864154    Free PMC article.
The Role of the Immune Metabolic Prognostic Index in Patients with Non-Small Cell Lung Cancer (NSCLC) in Radiological Progression during Treatment with Nivolumab.
Matteo Bauckneht, Carlo Genova, +16 authors, Silvia Morbelli.
Cancers (Basel), 2021 Jul 03; 13(13). PMID: 34206545    Free PMC article.
Comparison Between 18F-FDG PET-Based and CT-Based Criteria in Non-Small Cell Lung Cancer Patients Treated with Nivolumab.
Giovanni Rossi, Matteo Bauckneht, +12 authors, Francesco Grossi.
J Nucl Med, 2019 Dec 07; 61(7). PMID: 31806768
K-ras mutations in non-small-cell lung carcinoma: a review.
Sarit Aviel-Ronen, Fiona H Blackhall, Frances A Shepherd, Ming-Sound Tsao.
Clin Lung Cancer, 2006 Jul 28; 8(1). PMID: 16870043
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.
Cheryl L Day, Daniel E Kaufmann, +19 authors, Bruce D Walker.
Nature, 2006 Aug 22; 443(7109). PMID: 16921384
Highly Cited.
The Future of Cancer Diagnosis, Treatment and Surveillance: A Systemic Review on Immunotherapy and Immuno-PET Radiotracers.
Virginia Liberini, Riccardo Laudicella, +5 authors, Désirée Deandreis.
Molecules, 2021 May 01; 26(8). PMID: 33920423    Free PMC article.
Systematic Review.
Novel Radiotracer for ImmunoPET Imaging of PD-1 Checkpoint Expression on Tumor Infiltrating Lymphocytes.
Arutselvan Natarajan, Aaron T Mayer, +3 authors, Sanjiv S Gambhir.
Bioconjug Chem, 2015 Aug 27; 26(10). PMID: 26307602
Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer.
Hossein Borghaei, Luis Paz-Ares, +25 authors, Julie R Brahmer.
N Engl J Med, 2015 Sep 29; 373(17). PMID: 26412456    Free PMC article.
Highly Cited.
Understanding fibroblast activation protein (FAP): substrates, activities, expression and targeting for cancer therapy.
Elizabeth J Hamson, Fiona M Keane, +2 authors, Mark D Gorrell.
Proteomics Clin Appl, 2014 Jan 29; 8(5-6). PMID: 24470260
Peripheral natural killer cells and myeloid-derived suppressor cells correlate with anti-PD-1 responses in non-small cell lung cancer.
Je-In Youn, Su-Myeong Park, +20 authors, Hye Ryun Kim.
Sci Rep, 2020 Jun 05; 10(1). PMID: 32493990    Free PMC article.
Evaluating response to immunotherapy with 18F-FDG PET/CT: where do we stand?
Nicolas Aide, Michel De Pontdeville, Egesta Lopci.
Eur J Nucl Med Mol Imaging, 2020 Jan 31; 47(5). PMID: 31996974
Decoding Tumor Phenotypes for ALK, ROS1, and RET Fusions in Lung Adenocarcinoma Using a Radiomics Approach.
Hyun Jung Yoon, Insuk Sohn, +7 authors, Jhingook Kim.
Medicine (Baltimore), 2015 Oct 16; 94(41). PMID: 26469915    Free PMC article.
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications.
Yuanyuan Zhang, Zemin Zhang.
Cell Mol Immunol, 2020 Jul 03; 17(8). PMID: 32612154    Free PMC article.
Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057-1061.
Shohei Hori, Takashi Nomura, Shimon Sakaguchi.
J Immunol, 2017 Jan 25; 198(3). PMID: 28115586
Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab.
David R Gandara, Sarah M Paul, +19 authors, David S Shames.
Nat Med, 2018 Aug 08; 24(9). PMID: 30082870
Highly Cited.
Absolute number of new lesions on 18F-FDG PET/CT is more predictive of clinical response than SUV changes in metastatic melanoma patients receiving ipilimumab.
Hoda Anwar, Christos Sachpekidis, +4 authors, Antonia Dimitrakopoulou-Strauss.
Eur J Nucl Med Mol Imaging, 2017 Nov 11; 45(3). PMID: 29124281
Assessing EGFR gene mutation status in non-small cell lung cancer with imaging features from PET/CT.
Mengmeng Jiang, Yiqian Zhang, +7 authors, Mengsu Zeng.
Nucl Med Commun, 2019 Jul 11; 40(8). PMID: 31290849
Therapy for Stage IV Non-Small-Cell Lung Cancer Without Driver Alterations: ASCO and OH (CCO) Joint Guideline Update.
Nasser H Hanna, Bryan J Schneider, +20 authors, Gregory Masters.
J Clin Oncol, 2020 Jan 29; 38(14). PMID: 31990617
Assessing PD-L1 Expression Level by Radiomic Features From PET/CT in Nonsmall Cell Lung Cancer Patients: An Initial Result.
Mengmeng Jiang, Dazhen Sun, +4 authors, Xiuzhong Yao.
Acad Radiol, 2019 May 31; 27(2). PMID: 31147234
Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden.
Matthew D Hellmann, Tudor-Eliade Ciuleanu, +21 authors, Luis Paz-Ares.
N Engl J Med, 2018 Apr 17; 378(22). PMID: 29658845    Free PMC article.
Highly Cited.
The Role of VEGF Receptors as Molecular Target in Nuclear Medicine for Cancer Diagnosis and Combination Therapy.
Katarzyna Masłowska, Paweł Krzysztof Halik, +2 authors, Ewa Gniazdowska.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33802353    Free PMC article.
Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy.
Filippo Galli, Jesus Vera Aguilera, +3 authors, Alberto Signore.
J Exp Clin Cancer Res, 2020 May 20; 39(1). PMID: 32423420    Free PMC article.
Comparison of RECIST, iRECIST, and PERCIST for the Evaluation of Response to PD-1/PD-L1 Blockade Therapy in Patients With Non-Small Cell Lung Cancer.
Lucian Beer, Maximilian Hochmair, +10 authors, Helmut Prosch.
Clin Nucl Med, 2019 Apr 26; 44(7). PMID: 31021918
ARID1A alterations function as a biomarker for longer progression-free survival after anti-PD-1/PD-L1 immunotherapy.
Ryosuke Okamura, Shumei Kato, +3 authors, Razelle Kurzrock.
J Immunother Cancer, 2020 Mar 01; 8(1). PMID: 32111729    Free PMC article.
Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis.
Alexandra Snyder, Tavi Nathanson, +18 authors, Dean F Bajorin.
PLoS Med, 2017 May 30; 14(5). PMID: 28552987    Free PMC article.
Highly Cited.
Introduction to Radiomics.
Marius E Mayerhoefer, Andrzej Materka, +4 authors, Gary Cook.
J Nucl Med, 2020 Feb 16; 61(4). PMID: 32060219
The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients.
Vyara Matson, Jessica Fessler, +5 authors, Thomas F Gajewski.
Science, 2018 Jan 06; 359(6371). PMID: 29302014    Free PMC article.
Highly Cited.
Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
D Planchard, S Popat, +9 authors, ESMO Guidelines Committee.
Ann Oncol, 2018 Oct 05; 29(Suppl 4). PMID: 30285222
Highly Cited.
Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria.
Jedd D Wolchok, Axel Hoos, +9 authors, F Stephen Hodi.
Clin Cancer Res, 2009 Nov 26; 15(23). PMID: 19934295
Highly Cited.
Blood Immune Cell Biomarkers in Patient With Lung Cancer Undergoing Treatment With Checkpoint Blockade.
Miriam Möller, Steffi Turzer, +2 authors, Dagmar Riemann.
J Immunother, 2019 Oct 09; 43(2). PMID: 31592989    Free PMC article.
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.
Alessandro Liberati, Douglas G Altman, +7 authors, David Moher.
J Clin Epidemiol, 2009 Jul 28; 62(10). PMID: 19631507
Highly Cited. Systematic Review.
Artificial Neural Networks in Cardiovascular Diseases and its Potential for Clinical Application in Molecular Imaging.
Riccardo Laudicella, Albert Comelli, +9 authors, Pierpaolo Alongi.
Curr Radiopharm, 2020 Jun 23; 14(3). PMID: 32564769
Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1.
Stéphane Champiat, Laurent Dercle, +8 authors, Charles Ferté.
Clin Cancer Res, 2016 Nov 09; 23(8). PMID: 27827313
Highly Cited.
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Ayelet Sivan, Leticia Corrales, +9 authors, Thomas F Gajewski.
Science, 2015 Nov 07; 350(6264). PMID: 26541606    Free PMC article.
Highly Cited.
Chimeric antigen receptor T cells are vulnerable to immunosuppressive mechanisms present within the tumor microenvironment.
Gregory L Beatty, Edmund K Moon.
Oncoimmunology, 2015 May 06; 3(11). PMID: 25941599    Free PMC article.
Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha.
Matthew Kraman, Paul J Bambrough, +6 authors, Douglas T Fearon.
Science, 2010 Nov 06; 330(6005). PMID: 21051638
Highly Cited.
Myeloid-Derived Suppressor Cells Hinder the Anti-Cancer Activity of Immune Checkpoint Inhibitors.
Rebekka Weber, Viktor Fleming, +5 authors, Viktor Umansky.
Front Immunol, 2018 Jun 27; 9. PMID: 29942309    Free PMC article.
Highly Cited. Review.
Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo.
D Gabrilovich, T Ishida, +4 authors, D P Carbone.
Blood, 1998 Dec 03; 92(11). PMID: 9834220
Highly Cited.
Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer.
Matthew D Hellmann, Tavi Nathanson, +29 authors, Jedd D Wolchok.
Cancer Cell, 2018 Apr 17; 33(5). PMID: 29657128    Free PMC article.
Highly Cited.
Personalizing NSCLC therapy by characterizing tumors using TKI-PET and immuno-PET.
I Bahce, M Yaqub, +3 authors, N H Hendrikse.
Lung Cancer, 2016 Jun 21; 107. PMID: 27319335
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.
Yuliya Pylayeva-Gupta, Kyoung Eun Lee, +2 authors, Dafna Bar-Sagi.
Cancer Cell, 2012 Jun 16; 21(6). PMID: 22698407    Free PMC article.
Highly Cited.
Discordance of immunotherapy response predictive biomarkers between primary lesions and paired metastases in tumours: A systematic review and meta-analysis.
Yutian Zou, Xiaoqian Hu, +5 authors, Xiaoming Xie.
EBioMedicine, 2020 Dec 15; 63. PMID: 33310681    Free PMC article.
Systematic Review.
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade.
Daniela S Thommen, Viktor H Koelzer, +16 authors, Alfred Zippelius.
Nat Med, 2018 Jun 13; 24(7). PMID: 29892065    Free PMC article.
Highly Cited.
Comparison of iRECIST versus RECIST V.1.1 in patients treated with an anti-PD-1 or PD-L1 antibody: pooled FDA analysis.
Flora Mulkey, Marc R Theoret, +2 authors, Rajeshwari Sridhara.
J Immunother Cancer, 2020 Feb 29; 8(1). PMID: 32107275    Free PMC article.
PD-L1 Immunohistochemistry Comparability Study in Real-Life Clinical Samples: Results of Blueprint Phase 2 Project.
Ming Sound Tsao, Keith M Kerr, +25 authors, Fred R Hirsch.
J Thorac Oncol, 2018 May 26; 13(9). PMID: 29800747    Free PMC article.
Highly Cited.
Mechanisms regulating T-cell infiltration and activity in solid tumors.
E Lanitis, D Dangaj, M Irving, G Coukos.
Ann Oncol, 2017 Oct 19; 28(suppl_12). PMID: 29045511
Highly Cited.
A guide to cancer immunotherapy: from T cell basic science to clinical practice.
Alex D Waldman, Jill M Fritz, Michael J Lenardo.
Nat Rev Immunol, 2020 May 21; 20(11). PMID: 32433532    Free PMC article.
Prognostic and predictive value of tumor-infiltrating lymphocytes for clinical therapeutic research in patients with non-small cell lung cancer.
Dong-Qiang Zeng, Yun-Fang Yu, +4 authors, Qiu-Gen Hu.
Oncotarget, 2016 Feb 13; 7(12). PMID: 26871598    Free PMC article.
Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer.
Matthew D Hellmann, Luis Paz-Ares, +23 authors, Suresh S Ramalingam.
N Engl J Med, 2019 Sep 29; 381(21). PMID: 31562796
Highly Cited.
Will FAPI PET/CT Replace FDG PET/CT in the Next Decade? Point-An Important Diagnostic, Phenotypic, and Biomarker Role.
Jeremie Calais, Christine E Mona.
AJR Am J Roentgenol, 2020 Aug 07; 216(2). PMID: 32755205
Neoantigens in cancer immunotherapy.
Ton N Schumacher, Robert D Schreiber.
Science, 2015 Apr 04; 348(6230). PMID: 25838375
Highly Cited. Review.
The Importance of Biopsy in the Era of Molecular Medicine.
Etay Ziv, Jeremy C Durack, Stephen B Solomon.
Cancer J, 2016 Nov 22; 22(6). PMID: 27870685    Free PMC article.
The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment.
Vinit Kumar, Sima Patel, Evgenii Tcyganov, Dmitry I Gabrilovich.
Trends Immunol, 2016 Feb 10; 37(3). PMID: 26858199    Free PMC article.
Highly Cited. Review.
Predictive Power of a Radiomic Signature Based on 18F-FDG PET/CT Images for EGFR Mutational Status in NSCLC.
Xiaofeng Li, Guotao Yin, +6 authors, Wengui Xu.
Front Oncol, 2019 Nov 05; 9. PMID: 31681597    Free PMC article.
Review of Indications of FDA-Approved Immune Checkpoint Inhibitors per NCCN Guidelines with the Level of Evidence.
Raju K Vaddepally, Prakash Kharel, +2 authors, Abhinav B Chandra.
Cancers (Basel), 2020 Apr 05; 12(3). PMID: 32245016    Free PMC article.
18F-fluorodeoxyglucose positron emission tomography/computed tomography-based radiomic features for prediction of epidermal growth factor receptor mutation status and prognosis in patients with lung adenocarcinoma.
Bin Yang, Heng-Shan Ji, +8 authors, Guang-Ming Lu.
Transl Lung Cancer Res, 2020 Jul 18; 9(3). PMID: 32676320    Free PMC article.
89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer.
Frederike Bensch, Elly L van der Veen, +18 authors, Elisabeth G E de Vries.
Nat Med, 2018 Nov 28; 24(12). PMID: 30478423
Highly Cited.
Circulating T-cell Immunosenescence in Patients with Advanced Non-small Cell Lung Cancer Treated with Single-agent PD-1/PD-L1 Inhibitors or Platinum-based Chemotherapy.
Roberto Ferrara, Marie Naigeon, +21 authors, Nathalie Chaput.
Clin Cancer Res, 2020 Sep 06; 27(2). PMID: 32887723
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
Bertrand Routy, Emmanuelle Le Chatelier, +45 authors, Laurence Zitvogel.
Science, 2017 Nov 04; 359(6371). PMID: 29097494
Highly Cited.
Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy.
Richard Lee Barrett, Ellen Puré.
Elife, 2020 Dec 29; 9. PMID: 33370234    Free PMC article.
New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada.
P Therasse, S G Arbuck, +8 authors, S G Gwyther.
J Natl Cancer Inst, 2000 Feb 03; 92(3). PMID: 10655437
Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance.
Whijae Roh, Pei-Ling Chen, +37 authors, P Andrew Futreal.
Sci Transl Med, 2017 Mar 03; 9(379). PMID: 28251903    Free PMC article.
Highly Cited.
Hypoxia and the phenomenon of immune exclusion.
Violena Pietrobon, Francesco M Marincola.
J Transl Med, 2021 Jan 08; 19(1). PMID: 33407613    Free PMC article.
FDG PET/CT for Assessment of Immune Therapy: Opportunities and Understanding Pitfalls.
Steve Y Cho, Daniel T Huff, Robert Jeraj, Mark R Albertini.
Semin Nucl Med, 2020 Oct 17; 50(6). PMID: 33059821    Free PMC article.
The Intersection between Tumor Angiogenesis and Immune Suppression.
Osama E Rahma, F Stephen Hodi.
Clin Cancer Res, 2019 Apr 05; 25(18). PMID: 30944124
68Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer.
Clemens Kratochwil, Paul Flechsig, +15 authors, Frederik L Giesel.
J Nucl Med, 2019 Apr 08; 60(6). PMID: 30954939    Free PMC article.
Elements of cancer immunity and the cancer-immune set point.
Daniel S Chen, Ira Mellman.
Nature, 2017 Jan 20; 541(7637). PMID: 28102259
Highly Cited. Review.
Usefulness of gradient tree boosting for predicting histological subtype and EGFR mutation status of non-small cell lung cancer on 18F FDG-PET/CT.
Sho Koyasu, Mizuho Nishio, +2 authors, Kaori Togashi.
Ann Nucl Med, 2019 Oct 30; 34(1). PMID: 31659591
Signatures of mutational processes in human cancer.
Ludmil B Alexandrov, Serena Nik-Zainal, +72 authors, Michael R Stratton.
Nature, 2013 Aug 16; 500(7463). PMID: 23945592    Free PMC article.
Highly Cited.
First-in-Humans Imaging with 89Zr-Df-IAB22M2C Anti-CD8 Minibody in Patients with Solid Malignancies: Preliminary Pharmacokinetics, Biodistribution, and Lesion Targeting.
Neeta Pandit-Taskar, Michael A Postow, +18 authors, Jedd D Wolchok.
J Nucl Med, 2019 Oct 06; 61(4). PMID: 31586002    Free PMC article.
Allele Frequency-Adjusted Blood-Based Tumor Mutational Burden as a Predictor of Overall Survival for Patients With NSCLC Treated With PD-(L)1 Inhibitors.
Zhijie Wang, Jianchun Duan, +30 authors, Jie Wang.
J Thorac Oncol, 2019 Dec 18; 15(4). PMID: 31843683
Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors.
Kurt A Schalper, Michael Carleton, +18 authors, Ignacio Melero.
Nat Med, 2020 May 15; 26(5). PMID: 32405062    Free PMC article.
Hyperprogressive Disease in Patients with Non-Small Cell Lung Cancer Treated with Checkpoint Inhibitors: The Role of 18F-FDG PET/CT.
Angelo Castello, Sabrina Rossi, +2 authors, Egesta Lopci.
J Nucl Med, 2019 Dec 22; 61(6). PMID: 31862803
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer.
Julie Brahmer, Karen L Reckamp, +22 authors, David R Spigel.
N Engl J Med, 2015 Jun 02; 373(2). PMID: 26028407    Free PMC article.
Highly Cited.
Incidence of Pseudoprogression during Immune Checkpoint Inhibitor Therapy for Solid Tumors: A Systematic Review and Meta-Analysis.
Hyo Jung Park, Kyung Won Kim, +4 authors, Mizuki Nishino.
Radiology, 2020 Aug 05; 297(1). PMID: 32749204    Free PMC article.
Systematic Review.
Hypoxia dynamics on FMISO-PET in combination with PD-1/PD-L1 expression has an impact on the clinical outcome of patients with Head-and-neck Squamous Cell Carcinoma undergoing Chemoradiation.
Alexander Rühle, Anca-L Grosu, +8 authors, Nils H Nicolay.
Theranostics, 2020 Aug 18; 10(20). PMID: 32802199    Free PMC article.
Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing.
Hira Rizvi, Francisco Sanchez-Vega, +29 authors, Matthew D Hellmann.
J Clin Oncol, 2018 Jan 18; 36(7). PMID: 29337640    Free PMC article.
Highly Cited.
Is it time to change our vision of tumor metabolism prior to immunotherapy?
Fabio Grizzi, Angelo Castello, Egesta Lopci.
Eur J Nucl Med Mol Imaging, 2018 Mar 14; 45(6). PMID: 29532102
18F-FDG PET/CT Can Predict Development of Thyroiditis Due to Immunotherapy for Lung Cancer.
Naghmehossadat Eshghi, Linda L Garland, +3 authors, Phillip H Kuo.
J Nucl Med Technol, 2018 Mar 31; 46(3). PMID: 29599403
Checkpoint blockade in cancer immunotherapy.
Alan J Korman, Karl S Peggs, James P Allison.
Adv Immunol, 2006 May 30; 90. PMID: 16730267    Free PMC article.
Highly Cited. Review.
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Freddie Bray, Jacques Ferlay, +3 authors, Ahmedin Jemal.
CA Cancer J Clin, 2018 Sep 13; 68(6). PMID: 30207593
Highly Cited.
Imaging the Cancer Immune Environment and Its Response to Pharmacologic Intervention, Part 1: The Role of 18F-FDG PET/CT.
Amir Iravani, Rodney J Hicks.
J Nucl Med, 2020 May 24; 61(7). PMID: 32444375
PET in the management of locally advanced and metastatic NSCLC.
Willem Grootjans, Lioe-Fee de Geus-Oei, +3 authors, Johan Bussink.
Nat Rev Clin Oncol, 2015 Apr 29; 12(7). PMID: 25917254
Retraction notice: Padhani A. PET imaging of tumour hypoxia, Cancer Imaging 2006; 6: s117-s121.
Cancer Imaging, 2007 Jan 20; 7. PMID: 17234576    Free PMC article.
Innate and adaptive immune cells in the tumor microenvironment.
Thomas F Gajewski, Hans Schreiber, Yang-Xin Fu.
Nat Immunol, 2013 Sep 21; 14(10). PMID: 24048123    Free PMC article.
Highly Cited. Review.
Immune Marker Profiling and Programmed Death Ligand 1 Expression Across NSCLC Mutations.
Maria I Toki, Nikita Mani, +7 authors, David L Rimm.
J Thorac Oncol, 2018 Sep 30; 13(12). PMID: 30267840    Free PMC article.
18F-FDG uptake in PET/CT is a potential predictive biomarker of response to anti-PD-1 antibody therapy in non-small cell lung cancer.
Kazuki Takada, Gouji Toyokawa, +10 authors, Masaki Mori.
Sci Rep, 2019 Sep 19; 9(1). PMID: 31527660    Free PMC article.
Baseline metabolic tumor burden on FDG PET/CT scans predicts outcome in advanced NSCLC patients treated with immune checkpoint inhibitors.
Romain-David Seban, Laura Mezquita, +11 authors, Benjamin Besse.
Eur J Nucl Med Mol Imaging, 2019 Nov 23; 47(5). PMID: 31754795
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy.
Jonathan J Havel, Diego Chowell, Timothy A Chan.
Nat Rev Cancer, 2019 Feb 14; 19(3). PMID: 30755690    Free PMC article.
Highly Cited. Review.
VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors.
Thibault Voron, Orianne Colussi, +15 authors, Magali Terme.
J Exp Med, 2015 Jan 21; 212(2). PMID: 25601652    Free PMC article.
Highly Cited.
Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab.
Christiane Meyer, Laurène Cagnon, +6 authors, Daniel E Speiser.
Cancer Immunol Immunother, 2013 Dec 21; 63(3). PMID: 24357148
Highly Cited.
Predicting Response to Immunotherapy by Evaluating Tumors, Lymphoid Cell-Rich Organs, and Immune-Related Adverse Events Using FDG-PET/CT.
Tomomi Nobashi, Lucia Baratto, +5 authors, Erik Mittra.
Clin Nucl Med, 2019 Jan 29; 44(4). PMID: 30688730
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy.
Diego Chowell, Luc G T Morris, +17 authors, Timothy A Chan.
Science, 2017 Dec 09; 359(6375). PMID: 29217585    Free PMC article.
Highly Cited.
Early Detection of Checkpoint Inhibitor-Associated Myocarditis Using 68Ga-FAPI PET/CT.
Daniel Finke, Markus B Heckmann, +4 authors, Lorenz H Lehmann.
Front Cardiovasc Med, 2021 Mar 16; 8. PMID: 33718446    Free PMC article.
18F-Fludeoxyglucose PET/Computed Tomography for Assessing Tumor Response to Immunotherapy and Detecting Immune-Related Side Effects: A Checklist for the PET Reader.
Kevin Prigent, Nicolas Aide.
PET Clin, 2019 Nov 19; 15(1). PMID: 31735296
Associations Between Somatic Mutations and Metabolic Imaging Phenotypes in Non-Small Cell Lung Cancer.
Stephen S F Yip, John Kim, +5 authors, Hugo J W L Aerts.
J Nucl Med, 2016 Oct 01; 58(4). PMID: 27688480    Free PMC article.
Highly Cited.
Prognostic Effect of Tumor Lymphocytic Infiltration in Resectable Non-Small-Cell Lung Cancer.
Elisabeth Brambilla, Gwénaël Le Teuff, +14 authors, Ming Sound Tsao.
J Clin Oncol, 2016 Feb 03; 34(11). PMID: 26834066    Free PMC article.
Highly Cited.
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.
Noriho Iida, Amiran Dzutsev, +18 authors, Romina S Goldszmid.
Science, 2013 Nov 23; 342(6161). PMID: 24264989    Free PMC article.
Highly Cited.
FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0.
Ronald Boellaard, Roberto Delgado-Bolton, +26 authors, European Association of Nuclear Medicine (EANM).
Eur J Nucl Med Mol Imaging, 2014 Dec 03; 42(2). PMID: 25452219    Free PMC article.
Highly Cited.
Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors.
Violena Pietrobon, Alessandra Cesano, Francesco Marincola, Jakob Nikolas Kather.
Front Immunol, 2021 Feb 16; 11. PMID: 33584676    Free PMC article.
Tracking tumor biology with radiomics: A systematic review utilizing a radiomics quality score.
Sebastian Sanduleanu, Henry C Woodruff, +4 authors, Philippe Lambin.
Radiother Oncol, 2018 May 22; 127(3). PMID: 29779918
Highly Cited. Systematic Review.
Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients.
Alice O Kamphorst, Rathi N Pillai, +16 authors, Suresh S Ramalingam.
Proc Natl Acad Sci U S A, 2017 Apr 28; 114(19). PMID: 28446615    Free PMC article.
Highly Cited.
Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma.
Jeffrey J Wallin, Johanna C Bendell, +19 authors, David F McDermott.
Nat Commun, 2016 Aug 31; 7. PMID: 27571927    Free PMC article.
Highly Cited.
PET/CT imaging for evaluation of multimodal treatment efficacy and toxicity in advanced NSCLC-current state and future directions.
Chukwuka Eze, Nina-Sophie Schmidt-Hegemann, +11 authors, Marcus Unterrainer.
Eur J Nucl Med Mol Imaging, 2021 Mar 25; 48(12). PMID: 33760957    Free PMC article.
Additional Value of PET Radiomic Features for the Initial Staging of Prostate Cancer: A Systematic Review from the Literature.
Priscilla Guglielmo, Francesca Marturano, +3 authors, Laura Evangelista.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885135    Free PMC article.
Non-conventional and Investigational PET Radiotracers for Breast Cancer: A Systematic Review.
Michele Balma, Virginia Liberini, +15 authors, Désirée Deandreis.
Front Med (Lausanne), 2022 May 03; 9. PMID: 35492341    Free PMC article.
Systematic Review.