Review
. 2021 Oct; 13(19):.
doi: 10.3390/cancers13194904.

Remodeling the Tumor Myeloid Landscape to Enhance Antitumor Antibody Immunotherapies

Khiyam Hussain 1 Mark S Cragg 1 Stephen A Beers 1 
Affiliations
  • PMID: 34638388
  •     249 References
  •     2 citations

Abstract

Among the diverse tumor resident immune cell types, tumor-associated macrophages (TAMs) are often the most abundant, possess an anti-inflammatory phenotype, orchestrate tumor immune evasion and are frequently associated with poor prognosis. However, TAMs can also be harnessed to destroy antibody-opsonized tumor cells through the process of antibody-dependent cellular phagocytosis (ADCP). Clinically important tumor-targeting monoclonal antibodies (mAb) such as Rituximab, Herceptin and Cetuximab, function, at least in part, by inducing macrophages to eliminate tumor cells via ADCP. For IgG mAb, this is mediated by antibody-binding activating Fc gamma receptors (FcγR), with resultant phagocytic activity impacted by the level of co-engagement with the single inhibitory FcγRIIb. Approaches to enhance ADCP in the tumor microenvironment include the repolarization of TAMs to proinflammatory phenotypes or the direct augmentation of ADCP by targeting so-called 'phagocytosis checkpoints'. Here we review the most promising new strategies targeting the cell surface molecules present on TAMs, which include the inhibition of 'don't eat me signals' or targeting immunostimulatory pathways with agonistic mAb and small molecules to augment tumor-targeting mAb immunotherapies and overcome therapeutic resistance.

Keywords: antibody immunotherapy; antibody-dependent cellular phagocytosis; phagocytosis checkpoints; resistance; tumor-associated macrophages.

The cellular and molecular origin of tumor-associated macrophages.
Ruth A Franklin, Will Liao, +5 authors, Ming O Li.
Science, 2014 May 09; 344(6186). PMID: 24812208    Free PMC article.
Highly Cited.
Protumoral TSP50 Regulates Macrophage Activities and Polarization via Production of TNF-α and IL-1β, and Activation of the NF-κB Signaling Pathway.
Cheng Yang, Dong-Mei Zhang, +5 authors, Yu-Xin Li.
PLoS One, 2015 Dec 20; 10(12). PMID: 26684869    Free PMC article.
The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis.
Alessia Cotena, Siamon Gordon, Nick Platt.
J Immunol, 2004 Nov 06; 173(10). PMID: 15528383
A review of rituximab, the first anti-CD20 monoclonal antibody used in the treatment of B non-Hodgkin's lymphomas.
Pierre Feugier.
Future Oncol, 2015 May 09; 11(9). PMID: 25952779
Review.
Tissue-Resident Macrophage Ontogeny and Homeostasis.
Florent Ginhoux, Martin Guilliams.
Immunity, 2016 Mar 18; 44(3). PMID: 26982352
Highly Cited. Review.
HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding.
Des C Jones, Vasilis Kosmoliaptsis, +8 authors, Rachel L Allen.
J Immunol, 2011 Jan 29; 186(5). PMID: 21270408
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.
Kipp Weiskopf, Aaron M Ring, +8 authors, K Christopher Garcia.
Science, 2013 Jun 01; 341(6141). PMID: 23722425    Free PMC article.
Highly Cited.
The yin-yang of the interaction between myelomonocytic cells and NK cells.
Martina Molgora, Domenico Supino, +4 authors, Cecilia Garlanda.
Scand J Immunol, 2018 Jul 27; 88(3). PMID: 30048003    Free PMC article.
Review.
Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity.
Hui-Ming Chen, William van der Touw, +16 authors, Shu-Hsia Chen.
J Clin Invest, 2018 Oct 24; 128(12). PMID: 30352428    Free PMC article.
Nivolumab Versus Docetaxel in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer: Two-Year Outcomes From Two Randomized, Open-Label, Phase III Trials (CheckMate 017 and CheckMate 057).
Leora Horn, David R Spigel, +26 authors, Wilfried E E Eberhardt.
J Clin Oncol, 2017 Oct 13; 35(35). PMID: 29023213    Free PMC article.
Highly Cited.
Targeting Macrophage-Recruiting Chemokines as a Novel Therapeutic Strategy to Prevent the Progression of Solid Tumors.
David Argyle, Takanori Kitamura.
Front Immunol, 2018 Nov 30; 9. PMID: 30483271    Free PMC article.
Review.
Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.
Michele De Palma, Mary Anna Venneri, +4 authors, Luigi Naldini.
Cancer Cell, 2005 Sep 20; 8(3). PMID: 16169466
Highly Cited.
Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor.
Benjamin E Willcox, Leonard M Thomas, Pamela J Bjorkman.
Nat Immunol, 2003 Aug 05; 4(9). PMID: 12897781
Clinical Trials of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma.
Anne Dyhl-Polk, Marta Kramer Mikkelsen, Morten Ladekarl, Dorte Lisbet Nielsen.
J Clin Med, 2021 Jul 03; 10(12). PMID: 34208788    Free PMC article.
Review.
The other side of scavenger receptors: pattern recognition for host defense.
M Krieger.
Curr Opin Lipidol, 1997 Oct 23; 8(5). PMID: 9335951
Review.
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets.
R A Clynes, T L Towers, L G Presta, J V Ravetch.
Nat Med, 2000 Mar 31; 6(4). PMID: 10742152
Highly Cited.
TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding.
Penka S Petrova, Natasja Nielsen Viller, +25 authors, Robert A Uger.
Clin Cancer Res, 2016 Nov 20; 23(4). PMID: 27856600
Misonidazole in the preoperative and radical radiotherapy of bladder cancer.
H K Awwad, M M El Merzabani, +7 authors, M V Burgers.
Cancer Clin Trials, 1980 Jan 01; 3(3). PMID: 7438324
Pancreatic tumors show high levels of hypoxia.
A C Koong, V K Mehta, +5 authors, M Vierra.
Int J Radiat Oncol Biol Phys, 2000 Nov 10; 48(4). PMID: 11072146
Highly Cited.
PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection.
Cheng J Ma, Lei Ni, +6 authors, Zhi Q Yao.
Immunology, 2010 Nov 26; 132(3). PMID: 21091911    Free PMC article.
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans.
Gregory L Beatty, Elena G Chiorean, +10 authors, Robert H Vonderheide.
Science, 2011 Mar 26; 331(6024). PMID: 21436454    Free PMC article.
Highly Cited.
Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies.
Capucine L Grandjean, Fabricio Montalvao, +7 authors, Philippe Bousso.
Sci Rep, 2016 Oct 05; 6. PMID: 27698437    Free PMC article.
Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression.
Hiroshi Fujimoto, Takafumi Sangai, +4 authors, Atsushi Ochiai.
Int J Cancer, 2009 May 30; 125(6). PMID: 19479998
Highly Cited.
Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV.
Veronique Minard-Colin, Yan Xiu, +5 authors, Thomas F Tedder.
Blood, 2008 May 23; 112(4). PMID: 18495955    Free PMC article.
Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits.
Bryna Erblich, Liyin Zhu, +2 authors, Jeffrey W Pollard.
PLoS One, 2011 Nov 03; 6(10). PMID: 22046273    Free PMC article.
Highly Cited.
Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer.
Jorge Blando, Anu Sharma, +20 authors, Padmanee Sharma.
Proc Natl Acad Sci U S A, 2019 Jan 13; 116(5). PMID: 30635425    Free PMC article.
Highly Cited.
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.
Sydney R Gordon, Roy L Maute, +10 authors, Irving L Weissman.
Nature, 2017 May 18; 545(7655). PMID: 28514441    Free PMC article.
Highly Cited.
Enhancing antibody-dependent cellular phagocytosis by Re-education of tumor-associated macrophages with resiquimod-encapsulated liposomes.
Hao Li, Masaharu Somiya, Shun'ichi Kuroda.
Biomaterials, 2020 Dec 19; 268. PMID: 33338932
Phagocytosis and clearance of apoptotic cells is mediated by MER.
R S Scott, E J McMahon, +5 authors, G K Matsushima.
Nature, 2001 May 11; 411(6834). PMID: 11346799
Highly Cited.
Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis.
Héloïse Beutier, Béatrice Hechler, +13 authors, Friederike Jönsson.
Sci Immunol, 2018 Apr 15; 3(22). PMID: 29654057
CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma.
Ranjana Advani, Ian Flinn, +18 authors, Sonali M Smith.
N Engl J Med, 2018 Nov 01; 379(18). PMID: 30380386    Free PMC article.
Highly Cited.
Multiple roles of chemokine (C-C motif) ligand 2 in promoting prostate cancer growth.
Jian Zhang, Yi Lu, Kenneth J Pienta.
J Natl Cancer Inst, 2010 Mar 18; 102(8). PMID: 20233997    Free PMC article.
Highly Cited. Review.
The Role of Complement in the Mechanism of Action of Therapeutic Anti-Cancer mAbs.
Josée Golay, Ronald P Taylor.
Antibodies (Basel), 2020 Nov 01; 9(4). PMID: 33126570    Free PMC article.
Review.
Macrophage diversity enhances tumor progression and metastasis.
Bin-Zhi Qian, Jeffrey W Pollard.
Cell, 2010 Apr 08; 141(1). PMID: 20371344    Free PMC article.
Highly Cited. Review.
Anti-PD-1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases.
Pooja Dhupkar, Nancy Gordon, John Stewart, Eugenie S Kleinerman.
Cancer Med, 2018 May 08; 7(6). PMID: 29733528    Free PMC article.
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.
Noelia A-Gonzalez, Steven J Bensinger, +15 authors, Antonio Castrillo.
Immunity, 2009 Aug 04; 31(2). PMID: 19646905    Free PMC article.
Highly Cited.
Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy.
Yasuhito Hamaguchi, Yan Xiu, +2 authors, Thomas F Tedder.
J Exp Med, 2006 Mar 08; 203(3). PMID: 16520392    Free PMC article.
Non-professional phagocytosis: a general feature of normal tissue cells.
Jacob C Seeberg, Monika Loibl, +13 authors, Luitpold V Distel.
Sci Rep, 2019 Aug 17; 9(1). PMID: 31417141    Free PMC article.
Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages.
Stefano Ugel, Francesco De Sanctis, Susanna Mandruzzato, Vincenzo Bronte.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325033    Free PMC article.
Highly Cited. Review.
The impact of hypoxia on tumor-associated macrophages.
Anne-Theres Henze, Massimiliano Mazzone.
J Clin Invest, 2016 Aug 03; 126(10). PMID: 27482883    Free PMC article.
Highly Cited. Review.
Nod2 is required for antigen-specific humoral responses against antigens orally delivered using a recombinant Lactobacillus vaccine platform.
Sara A Bumgardner, Lin Zhang, +5 authors, Gregg A Dean.
PLoS One, 2018 May 08; 13(5). PMID: 29734365    Free PMC article.
Macrophage plasticity and polarization in tissue repair and remodelling.
Alberto Mantovani, Subhra K Biswas, +2 authors, Massimo Locati.
J Pathol, 2012 Oct 26; 229(2). PMID: 23096265
Highly Cited. Review.
Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy.
Amira A Barkal, Kipp Weiskopf, +15 authors, Roy L Maute.
Nat Immunol, 2017 Nov 29; 19(1). PMID: 29180808    Free PMC article.
Highly Cited.
PD-1 signaling in primary T cells.
James L Riley.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426218    Free PMC article.
Highly Cited. Review.
Tumor hypoxia and malignant progression.
Peter Vaupel, Arnulf Mayer, Michael Höckel.
Methods Enzymol, 2004 Apr 06; 381. PMID: 15063685
Highly Cited.
A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation.
Esther N Arwert, Allison S Harney, +4 authors, John S Condeelis.
Cell Rep, 2018 May 03; 23(5). PMID: 29719241    Free PMC article.
Highly Cited.
Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors.
R Rampling, G Cruickshank, +2 authors, P Workman.
Int J Radiat Oncol Biol Phys, 1994 Jun 15; 29(3). PMID: 8005794
Murine Th1 and Th2 cell clones differentially regulate macrophage nitric oxide production.
D D Taub, G W Cox.
J Leukoc Biol, 1995 Jul 01; 58(1). PMID: 7616109
Improved survival with ipilimumab in patients with metastatic melanoma.
F Stephen Hodi, Steven J O'Day, +26 authors, Walter J Urba.
N Engl J Med, 2010 Jun 08; 363(8). PMID: 20525992    Free PMC article.
Highly Cited.
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.
H Zhong, A M De Marzo, +7 authors, J W Simons.
Cancer Res, 1999 Dec 03; 59(22). PMID: 10582706
Highly Cited.
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
P C Maisonpierre, C Suri, +11 authors, G D Yancopoulos.
Science, 1997 Jul 04; 277(5322). PMID: 9204896
Highly Cited.
GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.
David H Munn, Madhav D Sharma, +4 authors, Andrew L Mellor.
Immunity, 2005 May 17; 22(5). PMID: 15894280
Highly Cited.
Origin and functions of tissue macrophages.
Slava Epelman, Kory J Lavine, Gwendalyn J Randolph.
Immunity, 2014 Jul 19; 41(1). PMID: 25035951    Free PMC article.
Highly Cited. Review.
Interaction between HLA-G and monocyte/macrophages in human pregnancy.
Ayesha Shakhawat, Valerie Shaikly, +3 authors, Nelson Fernández.
J Reprod Immunol, 2010 Apr 02; 85(1). PMID: 20356631
Review.
Oxygenation of squamous cell carcinoma of the head and neck: comparison of primary tumors, neck node metastases, and normal tissue.
A Becker, G Hänsgen, +3 authors, J Dunst.
Int J Radiat Oncol Biol Phys, 1998 Sep 25; 42(1). PMID: 9747817
ILT receptors at the interface between lymphoid and myeloid cells.
M Cella, H Nakajima, +2 authors, M Colonna.
Curr Top Microbiol Immunol, 2000 Oct 19; 251. PMID: 11036771
Macrophages define the invasive microenvironment in breast cancer.
Jeffrey W Pollard.
J Leukoc Biol, 2008 May 10; 84(3). PMID: 18467655    Free PMC article.
Highly Cited. Review.
Matrix metalloproteinases: regulators of the tumor microenvironment.
Kai Kessenbrock, Vicki Plaks, Zena Werb.
Cell, 2010 Apr 08; 141(1). PMID: 20371345    Free PMC article.
Highly Cited. Review.
Expression of the class A macrophage scavenger receptor on specific subpopulations of murine dendritic cells limits their endotoxin response.
Mike Becker, Alessia Cotena, Siamon Gordon, Nick Platt.
Eur J Immunol, 2006 Mar 23; 36(4). PMID: 16552714
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade.
Spencer C Wei, Jacob H Levine, +8 authors, James P Allison.
Cell, 2017 Aug 15; 170(6). PMID: 28803728    Free PMC article.
Highly Cited.
Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules.
M Colonna, J Samaridis, +7 authors, A Rolink.
J Immunol, 1998 Apr 08; 160(7). PMID: 9531263
Highly Cited.
Alternative activation of tumor-associated macrophages by IL-4: priming for protumoral functions.
Hao-Wei Wang, Johanna A Joyce.
Cell Cycle, 2010 Dec 15; 9(24). PMID: 21150330    Free PMC article.
Review.
Nonclinical evaluation of GMA161--an antihuman CD16 (FcγRIII) monoclonal antibody for treatment of autoimmune disorders in CD16 transgenic mice.
Meghan M Flaherty, Timothy K MacLachlan, +7 authors, Laura Andrews.
Toxicol Sci, 2011 Oct 26; 125(1). PMID: 22025730
Targeting macrophages: therapeutic approaches in cancer.
Luca Cassetta, Jeffrey W Pollard.
Nat Rev Drug Discov, 2018 Oct 27; 17(12). PMID: 30361552
Highly Cited. Review.
Fcgamma receptors as regulators of immune responses.
Falk Nimmerjahn, Jeffrey V Ravetch.
Nat Rev Immunol, 2007 Dec 08; 8(1). PMID: 18064051
Highly Cited. Review.
Metabolic Reprogramming of Immune Cells in Cancer Progression.
Subhra K Biswas.
Immunity, 2015 Sep 18; 43(3). PMID: 26377897
Highly Cited. Review.
TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity.
Xiaojie Yu, Sonya James, +14 authors, Mark S Cragg.
Commun Biol, 2021 Jun 25; 4(1). PMID: 34162985    Free PMC article.
Protection from lethal gram-positive infection by macrophage scavenger receptor-dependent phagocytosis.
C A Thomas, Y Li, +3 authors, J El Khoury.
J Exp Med, 2000 Jan 06; 191(1). PMID: 10620613    Free PMC article.
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
Oscar R Colegio, Ngoc-Quynh Chu, +10 authors, Ruslan Medzhitov.
Nature, 2014 Jul 22; 513(7519). PMID: 25043024    Free PMC article.
Highly Cited.
A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signaling.
Xiaoli Li, Jianming Wu, +4 authors, Robert P Kimberly.
Arthritis Rheum, 2003 Nov 13; 48(11). PMID: 14613290
Macrophage activation: priming activity from a T-cell hybridoma is attributable to interferon-gamma.
J L Pace, S W Russell, +2 authors, D H Katz.
Proc Natl Acad Sci U S A, 1983 Jun 01; 80(12). PMID: 6407020    Free PMC article.
Tumour-associated macrophages as treatment targets in oncology.
Alberto Mantovani, Federica Marchesi, +2 authors, Paola Allavena.
Nat Rev Clin Oncol, 2017 Jan 25; 14(7). PMID: 28117416    Free PMC article.
Highly Cited. Review.
HER2 therapy--an abundance of riches.
William J Gradishar.
N Engl J Med, 2011 Dec 14; 366(2). PMID: 22149874
A lineage of myeloid cells independent of Myb and hematopoietic stem cells.
Christian Schulz, Elisa Gomez Perdiguero, +10 authors, Frederic Geissmann.
Science, 2012 Mar 24; 336(6077). PMID: 22442384
Highly Cited.
Cetuximab for the treatment of colorectal cancer.
Derek J Jonker, Chris J O'Callaghan, +12 authors, Malcolm J Moore.
N Engl J Med, 2007 Nov 16; 357(20). PMID: 18003960
Highly Cited.
Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells.
Silke Eisinger, Dhifaf Sarhan, +17 authors, Mikael C I Karlsson.
Proc Natl Acad Sci U S A, 2020 Nov 25; 117(50). PMID: 33229588    Free PMC article.
Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.
Meike E W Logtenberg, J H Marco Jansen, +18 authors, Ton N Schumacher.
Nat Med, 2019 Mar 06; 25(4). PMID: 30833751    Free PMC article.
Highly Cited.
Role of macrophage scavenger receptors in response to Listeria monocytogenes infection in mice.
T Ishiguro, M Naito, +5 authors, T Kodama.
Am J Pathol, 2001 Jan 06; 158(1). PMID: 11141491    Free PMC article.
Alterations in the protein composition of maturing phagosomes.
A Pitt, L S Mayorga, P D Stahl, A L Schwartz.
J Clin Invest, 1992 Nov 01; 90(5). PMID: 1430221    Free PMC article.
Clinical experience with CD64-directed immunotherapy. An overview.
R T Curnow.
Cancer Immunol Immunother, 1998 Jan 22; 45(3-4). PMID: 9435876
Review.
Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model.
Sai Ping Lau, Nadine van Montfoort, +18 authors, Casper H J van Eijck.
J Immunother Cancer, 2020 Jul 22; 8(2). PMID: 32690771    Free PMC article.
A review of emerging and non-US FDA-approved topical agents for the treatment of basal cell carcinoma.
Natalie Kash, Sirunya Silapunt.
Future Oncol, 2021 Jun 23; 17(23). PMID: 34156307
Review.
Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells.
Annett Müller, Susan Brandenburg, +2 authors, Peter Vajkoczy.
Int J Cancer, 2014 Dec 06; 137(2). PMID: 25477239
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action.
F Michael Yakes, Wichai Chinratanalab, +3 authors, Carlos L Arteaga.
Cancer Res, 2002 Jul 19; 62(14). PMID: 12124352
Highly Cited.
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Frederick Arce Vargas, Andrew J S Furness, +32 authors, Sergio A Quezada.
Cancer Cell, 2018 Mar 27; 33(4). PMID: 29576375    Free PMC article.
Highly Cited.
Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies.
Elie Dheilly, Valéry Moine, +12 authors, Krzysztof Masternak.
Mol Ther, 2017 Feb 06; 25(2). PMID: 28153099    Free PMC article.
The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis.
Irene Mattiola, Federica Tomay, +21 authors, Massimo Locati.
Nat Immunol, 2019 Jul 03; 20(8). PMID: 31263276    Free PMC article.
Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions.
Seth B Coffelt, Andrea O Tal, +8 authors, Claire E Lewis.
Cancer Res, 2010 Jun 10; 70(13). PMID: 20530679
Highly Cited.
Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity.
Kelsey E Sivick, Anthony L Desbien, +22 authors, Sarah M McWhirter.
Cell Rep, 2018 Dec 13; 25(11). PMID: 30540940
Highly Cited.
Immunotherapy targeting inhibitory Fcγ receptor IIB (CD32b) in the mouse is limited by monoclonal antibody consumption and receptor internalization.
Emily L Williams, Alison L Tutt, +10 authors, Martin J Glennie.
J Immunol, 2013 Sep 13; 191(8). PMID: 24026082
Phagocytosis: receptors, signal integration, and the cytoskeleton.
Spencer A Freeman, Sergio Grinstein.
Immunol Rev, 2014 Oct 17; 262(1). PMID: 25319336
Highly Cited. Review.
Lactate-induced M2 polarization of tumor-associated macrophages promotes the invasion of pituitary adenoma by secreting CCL17.
Anke Zhang, Yuanzhi Xu, +11 authors, Meiqing Lou.
Theranostics, 2021 Mar 06; 11(8). PMID: 33664865    Free PMC article.
Macrophage polarization comes of age.
Alberto Mantovani, Antonio Sica, Massimo Locati.
Immunity, 2005 Oct 18; 23(4). PMID: 16226499
Highly Cited. Review.
Role of crosslinking for agonistic CD40 monoclonal antibodies as immune therapy of cancer.
Lee P Richman, Robert H Vonderheide.
Cancer Immunol Res, 2014 Jan 15; 2(1). PMID: 24416732    Free PMC article.
Epidermal Growth Factor Receptor Expression and Resistance Patterns to Targeted Therapy in Non-Small Cell Lung Cancer: A Review.
Emma-Anne Karlsen, Sam Kahler, +2 authors, Fiona Simpson.
Cells, 2021 Jun 03; 10(5). PMID: 34069119    Free PMC article.
Review.
Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis.
Anna-Maria Georgoudaki, Kajsa E Prokopec, +14 authors, Mikael C I Karlsson.
Cell Rep, 2016 May 24; 15(9). PMID: 27210762
Highly Cited.
Suppression, subversion and escape: the role of regulatory T cells in cancer progression.
K Oleinika, R J Nibbs, G J Graham, A R Fraser.
Clin Exp Immunol, 2012 Dec 04; 171(1). PMID: 23199321    Free PMC article.
Review.
SIRPα-CD47 Immune Checkpoint Blockade in Anticancer Therapy.
André Veillette, Jun Chen.
Trends Immunol, 2018 Jan 18; 39(3). PMID: 29336991
Highly Cited. Review.
VISTA is an immune checkpoint molecule for human T cells.
J Louise Lines, Eirini Pantazi, +8 authors, Randolph Noelle.
Cancer Res, 2014 Apr 03; 74(7). PMID: 24691993    Free PMC article.
Highly Cited.
Cytochemical study of esterase activity of human neoplasms and stromal macrophages.
B MONIS, T WEINBERG.
Cancer, 1961 Mar 01; 14. PMID: 13772036
Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.
Yu Zhu, John M Herndon, +12 authors, David G DeNardo.
Immunity, 2017 Aug 17; 47(2). PMID: 28813661    Free PMC article.
Highly Cited.
CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.
Amira A Barkal, Rachel E Brewer, +8 authors, Irving L Weissman.
Nature, 2019 Aug 02; 572(7769). PMID: 31367043    Free PMC article.
Highly Cited.
Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells.
Gloria Hoi Wan Tso, Helen Ka Wai Law, +2 authors, Yu Lung Lau.
Stem Cells, 2010 Mar 12; 28(5). PMID: 20222014
Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.
Tracie A Seimon, Amrom Obstfeld, +2 authors, Ira Tabas.
Proc Natl Acad Sci U S A, 2006 Dec 15; 103(52). PMID: 17167049    Free PMC article.
Alternative activation of macrophages: an immunologic functional perspective.
Fernando O Martinez, Laura Helming, Siamon Gordon.
Annu Rev Immunol, 2008 Dec 25; 27. PMID: 19105661
Highly Cited. Review.
CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization.
Hernan Roca, Zachary S Varsos, +3 authors, Kenneth J Pienta.
J Biol Chem, 2009 Oct 17; 284(49). PMID: 19833726    Free PMC article.
Highly Cited.
Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies.
Ann L White, H T Claude Chan, +15 authors, Martin J Glennie.
Cancer Cell, 2014 Dec 17; 27(1). PMID: 25500122    Free PMC article.
Macrophages: obligate partners for tumor cell migration, invasion, and metastasis.
John Condeelis, Jeffrey W Pollard.
Cell, 2006 Jan 28; 124(2). PMID: 16439202
Highly Cited. Review.
Hypoxia-inducible factors: crosstalk between inflammation and metabolism.
Jessica E S Shay, M Celeste Simon.
Semin Cell Dev Biol, 2012 Apr 25; 23(4). PMID: 22525300
Review.
Targeting the Antibody Checkpoints to Enhance Cancer Immunotherapy-Focus on FcγRIIB.
Ingrid Teige, Linda Mårtensson, Björn L Frendéus.
Front Immunol, 2019 Apr 02; 10. PMID: 30930905    Free PMC article.
Review.
Fcγ receptor dependency of agonistic CD40 antibody in lymphoma therapy can be overcome through antibody multimerization.
Ann L White, Lang Dou, +14 authors, Stephen A Beers.
J Immunol, 2014 Jul 16; 193(4). PMID: 25024386
Evidence for a gamma-interferon receptor that regulates macrophage tumoricidal activity.
A Celada, P W Gray, E Rinderknecht, R D Schreiber.
J Exp Med, 1984 Jul 01; 160(1). PMID: 6330272    Free PMC article.
Highly Cited.
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
Li Wang, Rotem Rubinstein, +10 authors, Randolph J Noelle.
J Exp Med, 2011 Mar 09; 208(3). PMID: 21383057    Free PMC article.
Highly Cited.
Phase I study of emactuzumab single agent or in combination with paclitaxel in patients with advanced/metastatic solid tumors reveals depletion of immunosuppressive M2-like macrophages.
C A Gomez-Roca, A Italiano, +21 authors, J-Y Blay.
Ann Oncol, 2019 May 23; 30(8). PMID: 31114846    Free PMC article.
CD32a antibodies induce thrombocytopenia and type II hypersensitivity reactions in FCGR2A mice.
Todd Meyer, Liza Robles-Carrillo, +5 authors, Ali Amirkhosravi.
Blood, 2015 Sep 24; 126(19). PMID: 26396093    Free PMC article.
Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment.
Kayla V Myers, Sarah R Amend, Kenneth J Pienta.
Mol Cancer, 2019 May 16; 18(1). PMID: 31088471    Free PMC article.
Highly Cited. Review.
The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies.
L Bingle, N J Brown, Claire E Lewis.
J Pathol, 2002 Feb 22; 196(3). PMID: 11857487
Highly Cited. Review.
Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.
R D Leek, C E Lewis, +3 authors, A L Harris.
Cancer Res, 1996 Oct 15; 56(20). PMID: 8840975
Highly Cited.
Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity.
Andrea Casazza, Damya Laoui, +7 authors, Massimiliano Mazzone.
Cancer Cell, 2013 Dec 18; 24(6). PMID: 24332039
Highly Cited.
CSF-1R inhibition alters macrophage polarization and blocks glioma progression.
Stephanie M Pyonteck, Leila Akkari, +17 authors, Johanna A Joyce.
Nat Med, 2013 Sep 24; 19(10). PMID: 24056773    Free PMC article.
Highly Cited.
Translating basic mechanisms of IgG effector activity into next generation cancer therapies.
Falk Nimmerjahn, Jeffrey V Ravetch.
Cancer Immun, 2012 Aug 17; 12. PMID: 22896758    Free PMC article.
Review.
Biologic response to anti-CD16 monoclonal antibody therapy in a human immunodeficiency virus-related immune thrombocytopenic purpura patient.
C Soubrane, J M Tourani, +7 authors, D Khayat.
Blood, 1993 Jan 01; 81(1). PMID: 8093346
Mechanism and Treatment of Rituximab Resistance in Diffuse Large Bcell Lymphoma.
Linqing Zou, Guoqi Song, +4 authors, William C Cho.
Curr Cancer Drug Targets, 2019 May 31; 19(9). PMID: 31142246
Review.
CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells.
Debbie C Strachan, Brian Ruffell, +4 authors, Dylan Daniel.
Oncoimmunology, 2014 Feb 06; 2(12). PMID: 24498562    Free PMC article.
Highly Cited.
CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3.
Jingqi Chen, Yandan Yao, +14 authors, Erwei Song.
Cancer Cell, 2011 Apr 13; 19(4). PMID: 21481794    Free PMC article.
Highly Cited.
The immunosuppressive and pro-tumor functions of CCL18 at the tumor microenvironment.
Ana Patrícia Cardoso, Marta Laranjeiro Pinto, +6 authors, Maria José Oliveira.
Cytokine Growth Factor Rev, 2021 Apr 18; 60. PMID: 33863622
Review.
Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection.
Stephen A Beers, Ruth R French, +13 authors, Mark S Cragg.
Blood, 2010 Mar 13; 115(25). PMID: 20223920
Highly Cited.
Differential macrophage programming in the tumor microenvironment.
Brian Ruffell, Nesrine I Affara, Lisa M Coussens.
Trends Immunol, 2012 Jan 27; 33(3). PMID: 22277903    Free PMC article.
Highly Cited. Review.
Turning enemies into allies-reprogramming tumor-associated macrophages for cancer therapy.
Martina Molgora, Marco Colonna.
Med (N Y), 2021 Jul 01; 2(6). PMID: 34189494    Free PMC article.
Review.
The cell biology of phagocytosis.
Ronald S Flannagan, Valentin Jaumouillé, Sergio Grinstein.
Annu Rev Pathol, 2011 Sep 14; 7. PMID: 21910624
Highly Cited. Review.
STING Activation Reverses Lymphoma-Mediated Resistance to Antibody Immunotherapy.
Lekh N Dahal, Lang Dou, +13 authors, Stephen A Beers.
Cancer Res, 2017 May 18; 77(13). PMID: 28512240    Free PMC article.
Agonistic CD40 Antibodies in Cancer Treatment.
Dijana Djureinovic, Meina Wang, Harriet M Kluger.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33804039    Free PMC article.
Review.
Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver.
G E Arteel, R G Thurman, J M Yates, J A Raleigh.
Br J Cancer, 1995 Oct 01; 72(4). PMID: 7547236    Free PMC article.
Highly Cited.
Studies on the mechanism of phagocytosis. I. Requirements for circumferential attachment of particle-bound ligands to specific receptors on the macrophage plasma membrane.
F M Griffin, J A Griffin, J E Leider, S C Silverstein.
J Exp Med, 1975 Nov 11; 142(5). PMID: 1194852    Free PMC article.
Highly Cited.
Clinical significance of macrophage heterogeneity in human malignant tumors.
Yoshihiro Komohara, Masahisa Jinushi, Motohiro Takeya.
Cancer Sci, 2013 Oct 31; 105(1). PMID: 24168081    Free PMC article.
Highly Cited. Review.
Macrophage infiltration of breast tumours: a prospective study.
I Lauder, W Aherne, J Stewart, R Sainsbury.
J Clin Pathol, 1977 Jun 01; 30(6). PMID: 874114    Free PMC article.
Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system.
Hideki Okazawa, Sei-ichiro Motegi, +6 authors, Takashi Matozaki.
J Immunol, 2005 Feb 09; 174(4). PMID: 15699129
Pembrolizumab in patients with advanced non-small-cell lung cancer (KEYNOTE-001): 3-year results from an open-label, phase 1 study.
Natasha B Leighl, Matthew D Hellmann, +14 authors, Edward B Garon.
Lancet Respir Med, 2019 Mar 17; 7(4). PMID: 30876831
Highly Cited.
The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway.
Aleksandra Deczkowska, Assaf Weiner, Ido Amit.
Cell, 2020 Jun 13; 181(6). PMID: 32531244
Review.
Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study.
Irene Brana, Antonio Calles, +7 authors, Emiliano Calvo.
Target Oncol, 2014 Jun 15; 10(1). PMID: 24928772
Monocyte-macrophage polarization and recruitment pathways in the tumour microenvironment of B-cell acute lymphoblastic leukaemia.
Erica Dander, Alessandra Fallati, +20 authors, Giovanna D'Amico.
Br J Haematol, 2021 Mar 14; 193(6). PMID: 33713428
Diversification of TAM receptor tyrosine kinase function.
Anna Zagórska, Paqui G Través, +2 authors, Greg Lemke.
Nat Immunol, 2014 Sep 10; 15(10). PMID: 25194421    Free PMC article.
Highly Cited.
Asymmetric and symmetric stem-cell divisions in development and cancer.
Sean J Morrison, Judith Kimble.
Nature, 2006 Jul 01; 441(7097). PMID: 16810241
Highly Cited. Review.
VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer.
Jianjun Gao, John F Ward, +16 authors, Padmanee Sharma.
Nat Med, 2017 Mar 28; 23(5). PMID: 28346412    Free PMC article.
Highly Cited.
Distinct role of macrophages in different tumor microenvironments.
Claire E Lewis, Jeffrey W Pollard.
Cancer Res, 2006 Jan 21; 66(2). PMID: 16423985
Highly Cited. Review.
Macrophages are critical effectors of antibody therapies for cancer.
Kipp Weiskopf, Irving L Weissman.
MAbs, 2015 Feb 11; 7(2). PMID: 25667985    Free PMC article.
Highly Cited. Review.
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
Alberto Mantovani, Silvano Sozzani, +2 authors, Antonio Sica.
Trends Immunol, 2002 Oct 29; 23(11). PMID: 12401408
Highly Cited. Review.
TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis.
Jonathan H M van der Meer, Tom van der Poll, Cornelis van 't Veer.
Blood, 2014 Mar 07; 123(16). PMID: 24596417
Review.
Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.
Gaetano Zizzo, Brendan A Hilliard, Marc Monestier, Philip L Cohen.
J Immunol, 2012 Sep 04; 189(7). PMID: 22942426    Free PMC article.
Highly Cited.
Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation.
Jason C Lenzo, Amanda L Turner, +4 authors, John A Hamilton.
Immunol Cell Biol, 2011 Jul 06; 90(4). PMID: 21727904
Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma.
Takehiko Shibata, David M Habiel, +3 authors, Cory M Hogaboam.
J Immunol, 2014 Mar 25; 192(8). PMID: 24659691    Free PMC article.
Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis.
Long-Yun Ye, Wei Chen, +8 authors, Ting-Bo Liang.
Cancer Res, 2016 Feb 04; 76(4). PMID: 26837767
Highly Cited.
Cancer-related inflammation.
Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill.
Nature, 2008 Jul 25; 454(7203). PMID: 18650914
Highly Cited. Review.
Macrophages regulate the angiogenic switch in a mouse model of breast cancer.
Elaine Y Lin, Jiu-Feng Li, +6 authors, Jeffrey W Pollard.
Cancer Res, 2006 Nov 23; 66(23). PMID: 17114237
Highly Cited.
Emerging Evasion Mechanisms of Macrophage Defenses by Pathogenic Bacteria.
Clarisse Leseigneur, Pierre Lê-Bury, Javier Pizarro-Cerdá, Olivier Dussurget.
Front Cell Infect Microbiol, 2020 Oct 27; 10. PMID: 33102257    Free PMC article.
Review.
Tumor-derived chemokine MCP-1/CCL2 is sufficient for mediating tumor tropism of adoptively transferred T cells.
Christine E Brown, Reena P Vishwanath, +4 authors, Michael C Jensen.
J Immunol, 2007 Aug 22; 179(5). PMID: 17709550
L-arginine availability regulates T-lymphocyte cell-cycle progression.
Paulo C Rodriguez, David G Quiceno, Augusto C Ochoa.
Blood, 2006 Oct 07; 109(4). PMID: 17023580    Free PMC article.
Highly Cited.
Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer.
Yonatan Katzenelenbogen, Fadi Sheban, +13 authors, Ido Amit.
Cell, 2020 Aug 14; 182(4). PMID: 32783915
Quantitative analysis of membrane remodeling at the phagocytic cup.
Warren L Lee, David Mason, Alan D Schreiber, Sergio Grinstein.
Mol Biol Cell, 2007 May 18; 18(8). PMID: 17507658    Free PMC article.
Interferons: signaling, antiviral and viral evasion.
Cláudio A Bonjardim, Paulo C P Ferreira, Erna G Kroon.
Immunol Lett, 2008 Dec 09; 122(1). PMID: 19059436    Free PMC article.
Review.
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.
Jia Xue, Susanne V Schmidt, +18 authors, Joachim L Schultze.
Immunity, 2014 Feb 18; 40(2). PMID: 24530056    Free PMC article.
Highly Cited.
Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo.
Michael Zhang, Gregor Hutter, +13 authors, Samuel H Cheshier.
PLoS One, 2016 Apr 20; 11(4). PMID: 27092773    Free PMC article.
Highly Cited.
The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock.
R Haworth, N Platt, +6 authors, S Gordon.
J Exp Med, 1997 Nov 14; 186(9). PMID: 9348300    Free PMC article.
Trial watch: STING agonists in cancer therapy.
Julie Le Naour, Laurence Zitvogel, +2 authors, Guido Kroemer.
Oncoimmunology, 2020 Sep 17; 9(1). PMID: 32934881    Free PMC article.
Review.
Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages.
Rob J W Arts, Theo S Plantinga, +10 authors, Romana T Netea-Maier.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123869    Free PMC article.
Inhibitory Fcγ receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies.
Fubin Li, Jeffrey V Ravetch.
Science, 2011 Aug 20; 333(6045). PMID: 21852502    Free PMC article.
Highly Cited.
Macrophage activation and polarization: nomenclature and experimental guidelines.
Peter J Murray, Judith E Allen, +22 authors, Thomas A Wynn.
Immunity, 2014 Jul 19; 41(1). PMID: 25035950    Free PMC article.
Highly Cited.
Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature.
Qiong-wen Zhang, Lei Liu, +5 authors, Yu-quan Wei.
PLoS One, 2013 Jan 04; 7(12). PMID: 23284651    Free PMC article.
Highly Cited.
The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy.
Junji Uchida, Yasuhito Hamaguchi, +4 authors, Thomas F Tedder.
J Exp Med, 2004 Jun 24; 199(12). PMID: 15210744    Free PMC article.
Highly Cited.
The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures.
Jérôme Galon, Helen K Angell, Davide Bedognetti, Francesco M Marincola.
Immunity, 2013 Jul 31; 39(1). PMID: 23890060
Highly Cited. Review.
The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression.
Wen Pan, Shu Zhu, +17 authors, Jun Lu.
Immunity, 2017 Aug 17; 47(2). PMID: 28813659    Free PMC article.
Hypoxia in breast cancer: pathogenesis, characterization and biological/therapeutic implications.
P Vaupel, Susanne Briest, M Höckel.
Wien Med Wochenschr, 2002 Aug 10; 152(13-14). PMID: 12168517
Review.
Is the scavenger receptor MARCO a new immune checkpoint?
Mohamed S Arredouani.
Oncoimmunology, 2015 May 06; 3(10). PMID: 25941575    Free PMC article.
Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients.
Emanuela Romano, Monika Kusio-Kobialka, +7 authors, Daniel E Speiser.
Proc Natl Acad Sci U S A, 2015 Apr 29; 112(19). PMID: 25918390    Free PMC article.
Highly Cited.
CD32B, the human inhibitory Fc-gamma receptor IIB, as a target for monoclonal antibody therapy of B-cell lymphoma.
Christopher T Rankin, Maria-Concetta Veri, +10 authors, Ezio Bonvini.
Blood, 2006 Jun 08; 108(7). PMID: 16757681
Treatment of refractory immune thrombocytopenic purpura with an anti-Fc gamma-receptor antibody.
S B Clarkson, J B Bussel, +3 authors, J C Unkeless.
N Engl J Med, 1986 May 08; 314(19). PMID: 2939345
Highly Cited.
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.
James Larkin, Vanna Chiarion-Sileni, +28 authors, Jedd D Wolchok.
N Engl J Med, 2015 Jun 02; 373(1). PMID: 26027431    Free PMC article.
Highly Cited.
Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.
Gabriela Bindea, Bernhard Mlecnik, +14 authors, Jérôme Galon.
Immunity, 2013 Oct 22; 39(4). PMID: 24138885
Highly Cited.
Monoclonal antibody therapy for B-cell non-Hodgkin's lymphoma.
Bruce D Cheson, John P Leonard.
N Engl J Med, 2008 Aug 09; 359(6). PMID: 18687642
Highly Cited. Review.
M-1/M-2 macrophages and the Th1/Th2 paradigm.
C D Mills, K Kincaid, +2 authors, A M Hill.
J Immunol, 2000 Jun 08; 164(12). PMID: 10843666
Highly Cited.
Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.
Sharareh Gholamin, Siddhartha S Mitra, +31 authors, Samuel H Cheshier.
Sci Transl Med, 2017 Mar 17; 9(381). PMID: 28298418
Highly Cited.
Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction.
Guo-Yun Chen, Xi Chen, +17 authors, Yang Liu.
Nat Biotechnol, 2011 Apr 12; 29(5). PMID: 21478876    Free PMC article.
Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function.
Linnéa La Fleur, Johan Botling, +9 authors, Dhifaf Sarhan.
Cancer Res, 2020 Dec 10; 81(4). PMID: 33293426
Effect of CC chemokine receptor 2 CCR2 blockade on serum C-reactive protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte chemoattractant protein-1 promoter region.
Jim Gilbert, Julie Lekstrom-Himes, +6 authors, MLN1202 Study Group.
Am J Cardiol, 2011 Jan 21; 107(6). PMID: 21247529
Prognostic value of mitotic counts and Ki-67 immunoreactivity in adult-type granulosa cell tumour of the ovary.
E M Leuverink, B A Brennan, +4 authors, C J R Stewart.
J Clin Pathol, 2008 Apr 24; 61(8). PMID: 18430757
Review.
Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release.
J Monks, D Rosner, +4 authors, V A Fadok.
Cell Death Differ, 2005 Jan 14; 12(2). PMID: 15647754
Trial Watch: Toll-like receptor agonists in cancer immunotherapy.
Melody Smith, Elena García-Martínez, +5 authors, Lorenzo Galluzzi.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524908    Free PMC article.
Review.
CXCR4 signaling regulates metastatic onset by controlling neutrophil motility and response to malignant cells.
C Tulotta, C Stefanescu, +3 authors, B E Snaar-Jagalska.
Sci Rep, 2019 Feb 23; 9(1). PMID: 30787324    Free PMC article.
Identification and manipulation of tumor associated macrophages in human cancers.
Moniek Heusinkveld, Sjoerd H van der Burg.
J Transl Med, 2011 Dec 20; 9. PMID: 22176642    Free PMC article.
Highly Cited. Review.
Transformation of the tumour microenvironment by a CD40 agonist antibody correlates with improved responses to PD-L1 blockade in a mouse orthotopic pancreatic tumour model.
Nadia M Luheshi, Jane Coates-Ulrichsen, +8 authors, Robert W Wilkinson.
Oncotarget, 2016 Feb 27; 7(14). PMID: 26918344    Free PMC article.
Pediatric Tumors-Mediated Inhibitory Effect on NK Cells: The Case of Neuroblastoma and Wilms' Tumors.
Andrea Pelosi, Piera Filomena Fiore, +7 authors, Bruno Azzarone.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34069127    Free PMC article.
Review.
Sensitizing protective tumor microenvironments to antibody-mediated therapy.
Christian P Pallasch, Ilya Leskov, +15 authors, Michael T Hemann.
Cell, 2014 Feb 04; 156(3). PMID: 24485462    Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Radiotherapy and CD40 Activation Separately Augment Immunity to Checkpoint Blockade in Cancer.
Andrew J Rech, Hannah Dada, +4 authors, Robert H Vonderheide.
Cancer Res, 2018 May 31; 78(15). PMID: 29844122    Free PMC article.
The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging.
Fabricio Montalvao, Zacarias Garcia, +4 authors, Philippe Bousso.
J Clin Invest, 2013 Nov 02; 123(12). PMID: 24177426    Free PMC article.
IFN-alpha and IFN-gamma have different regulatory effects on IL-4-induced membrane expression of Fc epsilon RIIb and release of soluble Fc epsilon RIIb by human monocytes.
A A te Velde, F Rousset, +2 authors, C G Figdor.
J Immunol, 1990 Apr 15; 144(8). PMID: 2139077
IgG4 drives M2a macrophages to a regulatory M2b-like phenotype: potential implication in immune tolerance.
Rodolfo Bianchini, Franziska Roth-Walter, +5 authors, Erika Jensen-Jarolim.
Allergy, 2018 Oct 20; 74(3). PMID: 30338531    Free PMC article.
Macrophage plasticity and polarization: in vivo veritas.
Antonio Sica, Alberto Mantovani.
J Clin Invest, 2012 Mar 02; 122(3). PMID: 22378047    Free PMC article.
Highly Cited. Review.
Mechanisms of Resistance to Monoclonal Antibodies (mAbs) in Lymphoid Malignancies.
Pallawi Torka, Mathew Barth, Robert Ferdman, Francisco J Hernandez-Ilizaliturri.
Curr Hematol Malig Rep, 2019 Sep 29; 14(5). PMID: 31559580
Review.
Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells.
Masahisa Jinushi, Shigeki Chiba, +6 authors, Hideaki Tahara.
Proc Natl Acad Sci U S A, 2011 Jul 13; 108(30). PMID: 21746895    Free PMC article.
Highly Cited.
The human B cell-associated antigen CD24 is a single chain sialoglycoprotein.
S J Pirruccello, T W LeBien.
J Immunol, 1986 May 15; 136(10). PMID: 2939133
Mononuclear phagocyte heterogeneity in cancer: different subsets and activation states reaching out at the tumor site.
Damya Laoui, Eva Van Overmeire, +7 authors, Jo A Van Ginderachter.
Immunobiology, 2011 Aug 02; 216(11). PMID: 21803441
Review.
Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.
Mitsunori Shiroishi, Kouhei Tsumoto, +11 authors, Katsumi Maenaka.
Proc Natl Acad Sci U S A, 2003 Jul 11; 100(15). PMID: 12853576    Free PMC article.
Highly Cited.
The role of microglia and macrophages in glioma maintenance and progression.
Dolores Hambardzumyan, David H Gutmann, Helmut Kettenmann.
Nat Neurosci, 2015 Dec 30; 19(1). PMID: 26713745    Free PMC article.
Highly Cited. Review.
Tumor-Associated Macrophages in Human Breast, Colorectal, Lung, Ovarian and Prostate Cancers.
Irina Larionova, Gulnara Tuguzbaeva, +5 authors, Julia Kzhyshkowska.
Front Oncol, 2020 Nov 17; 10. PMID: 33194645    Free PMC article.
Review.
Humanised effector-null FcγRIIA antibody inhibits immune complex-mediated proinflammatory responses.
Bo Chen, Katherine A Vousden, +28 authors, Gary P Sims.
Ann Rheum Dis, 2018 Nov 22; 78(2). PMID: 30459279    Free PMC article.
M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer.
Eva M Garrido-Martin, Toby W P Mellows, +13 authors, Tilman Sanchez-Elsner.
J Immunother Cancer, 2020 Jul 24; 8(2). PMID: 32699181    Free PMC article.
VISTA Re-programs Macrophage Biology Through the Combined Regulation of Tolerance and Anti-inflammatory Pathways.
Mohamed A ElTanbouly, Evelien Schaafsma, +6 authors, Rodwell Mabaera.
Front Immunol, 2020 Nov 13; 11. PMID: 33178206    Free PMC article.
Tumour-educated macrophages promote tumour progression and metastasis.
Jeffrey W Pollard.
Nat Rev Cancer, 2004 Jan 07; 4(1). PMID: 14708027
Highly Cited. Review.
TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy.
Martina Molgora, Ekaterina Esaulova, +18 authors, Marco Colonna.
Cell, 2020 Aug 14; 182(4). PMID: 32783918    Free PMC article.
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy.
Alba Rodriguez-Garcia, Rachel C Lynn, +8 authors, Daniel J Powell.
Nat Commun, 2021 Feb 11; 12(1). PMID: 33563975    Free PMC article.
Expression of the inhibitory B7 family molecule VISTA in human colorectal carcinoma tumors.
Shan Xie, Jia Huang, +6 authors, Ling Ni.
Cancer Immunol Immunother, 2018 Aug 22; 67(11). PMID: 30128738
Macrophage biology in development, homeostasis and disease.
Thomas A Wynn, Ajay Chawla, Jeffrey W Pollard.
Nature, 2013 Apr 27; 496(7446). PMID: 23619691    Free PMC article.
Highly Cited. Review.
Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies.
Robert L Bowman, Florian Klemm, +11 authors, Johanna A Joyce.
Cell Rep, 2016 Nov 15; 17(9). PMID: 27840052    Free PMC article.
Highly Cited.
Blocking siglec-10hi tumor-associated macrophages improves anti-tumor immunity and enhances immunotherapy for hepatocellular carcinoma.
Nan Xiao, Xiaodong Zhu, +6 authors, Hui-Chuan Sun.
Exp Hematol Oncol, 2021 Jun 12; 10(1). PMID: 34112250    Free PMC article.
The lymphoreticular infiltrate in human tumours studied by electron microscopy and tissue culture.
J C Underwood, I Carr.
J Pathol, 1972 Jul 01; 107(3). PMID: 5084946
Scavenger receptor-A negatively regulates antitumor immunity.
Xiang-Yang Wang, John Facciponte, +2 authors, Elizabeth A Repasky.
Cancer Res, 2007 May 19; 67(10). PMID: 17510431
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Stephen B Willingham, Jens-Peter Volkmer, +41 authors, Irving L Weissman.
Proc Natl Acad Sci U S A, 2012 Mar 28; 109(17). PMID: 22451913    Free PMC article.
Highly Cited.
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection.
H Suzuki, Y Kurihara, +22 authors, T Kodama.
Nature, 1997 Mar 20; 386(6622). PMID: 9069289
Highly Cited.
Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity.
Shumei Kato, Ryosuke Okamura, +11 authors, Razelle Kurzrock.
Oncoimmunology, 2020 Mar 03; 9(1). PMID: 32117584    Free PMC article.
Functional activity of CD40 antibodies correlates to the position of binding relative to CD154.
T A Barr, A W Heath.
Immunology, 2001 Feb 13; 102(1). PMID: 11168635    Free PMC article.
Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis.
Romeo Ricci, Grzegorz Sumara, +15 authors, Thomas F Lüscher.
Science, 2004 Nov 30; 306(5701). PMID: 15567863
Anticancer effects of anti-CD47 immunotherapy in vivo.
Kristina Iribarren, Aitziber Buque, +6 authors, Guido Kroemer.
Oncoimmunology, 2019 Feb 07; 8(3). PMID: 30723582    Free PMC article.
Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo.
Markus Biburger, Susanne Aschermann, +6 authors, Falk Nimmerjahn.
Immunity, 2011 Dec 16; 35(6). PMID: 22169040
Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation.
Weilin Chen, Chaofeng Han, +9 authors, Xuetao Cao.
Cell, 2013 Feb 05; 152(3). PMID: 23374343
Highly Cited.
Macrophages eliminate circulating tumor cells after monoclonal antibody therapy.
Nuray Gül, Liane Babes, +7 authors, Marjolein van Egmond.
J Clin Invest, 2014 Jan 17; 124(2). PMID: 24430180    Free PMC article.
Highly Cited.
PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis.
Xin Huang, Fabienne Venet, +8 authors, Alfred Ayala.
Proc Natl Acad Sci U S A, 2009 Apr 01; 106(15). PMID: 19332785    Free PMC article.
Highly Cited.
The role of myeloid cells in the promotion of tumour angiogenesis.
Craig Murdoch, Munitta Muthana, Seth B Coffelt, Claire E Lewis.
Nat Rev Cancer, 2008 Jul 18; 8(8). PMID: 18633355
Highly Cited. Review.
Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy.
Carola H Ries, Michael A Cannarile, +24 authors, Dominik Rüttinger.
Cancer Cell, 2014 Jun 06; 25(6). PMID: 24898549
Highly Cited.
The histological structure of some human lung cancers and the possible implications for radiotherapy.
R H THOMLINSON, L H GRAY.
Br J Cancer, 1955 Dec 01; 9(4). PMID: 13304213    Free PMC article.
Highly Cited.
Macrophage migration and gene expression in response to tumor hypoxia.
Craig Murdoch, Claire E Lewis.
Int J Cancer, 2005 Aug 18; 117(5). PMID: 16106399
Review.
Vaccine adjuvant uses of poly-IC and derivatives.
Karen A O Martins, Sina Bavari, Andres M Salazar.
Expert Rev Vaccines, 2014 Oct 14; 14(3). PMID: 25308798
Review.
Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy.
Qian Gong, Qinglin Ou, +17 authors, Andrew C Chan.
J Immunol, 2005 Jan 07; 174(2). PMID: 15634903
Highly Cited.
IL-4 decreases Fc gamma R membrane expression and Fc gamma R-mediated cytotoxic activity of human monocytes.
A A te Velde, R J Huijbens, J E de Vries, C G Figdor.
J Immunol, 1990 Apr 15; 144(8). PMID: 2139076
Lysyl-tRNA synthetase-expressing colon spheroids induce M2 macrophage polarization to promote metastasis.
Seo Hee Nam, Doyeun Kim, +9 authors, Jung Weon Lee.
J Clin Invest, 2018 Sep 07; 128(11). PMID: 30188867    Free PMC article.
T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions.
S P Schoenberger, R E Toes, +2 authors, C J Melief.
Nature, 1998 Jun 12; 393(6684). PMID: 9624005
Highly Cited.
Extensive Ethnic Variation and Linkage Disequilibrium at the FCGR2/3 Locus: Different Genetic Associations Revealed in Kawasaki Disease.
Sietse Q Nagelkerke, Carline E Tacke, +23 authors, International Kawasaki Disease Genetics Consortium.
Front Immunol, 2019 Apr 06; 10. PMID: 30949161    Free PMC article.
Current Prospects of Molecular Therapeutics in Head and Neck Squamous Cell Carcinoma.
K Devaraja.
Pharmaceut Med, 2020 Jan 15; 33(4). PMID: 31933185
Review.
Siglecs and their roles in the immune system.
Paul R Crocker, James C Paulson, Ajit Varki.
Nat Rev Immunol, 2007 Mar 24; 7(4). PMID: 17380156
Highly Cited. Review.
Increased infiltration of CCR4-positive regulatory T cells in prostate cancer tissue is associated with a poor prognosis.
Masahito Watanabe, Kent Kanao, +12 authors, Makoto Sumitomo.
Prostate, 2019 Aug 08; 79(14). PMID: 31390096
NF-κB regulates PD-1 expression in macrophages.
Alexander P R Bally, Peiyuan Lu, +4 authors, Jeremy M Boss.
J Immunol, 2015 Mar 27; 194(9). PMID: 25810391    Free PMC article.
CD40 agonist-induced IL-12p40 potentiates hepatotoxicity.
Caroline Bonnans, Graham Thomas, +10 authors, Yan Qu.
J Immunother Cancer, 2020 Jun 01; 8(1). PMID: 32474414    Free PMC article.
Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms.
Subhra K Biswas, Antonio Sica, Claire E Lewis.
J Immunol, 2008 Feb 06; 180(4). PMID: 18250403
Highly Cited. Review.
Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages.
Yoshihiro Komohara, Kenichi Takemura, +5 authors, Motohiro Takeya.
Cancer Sci, 2009 Aug 22; 100(11). PMID: 19694752
Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis.
Sabina Sangaletti, Emma Di Carlo, +7 authors, Mario P Colombo.
Cancer Res, 2008 Nov 01; 68(21). PMID: 18974151
Tumor location determines tissue-specific recruitment of tumor-associated macrophages and antibody-dependent immunotherapy response.
Birgit Lehmann, Markus Biburger, +10 authors, Falk Nimmerjahn.
Sci Immunol, 2017 Aug 08; 2(7). PMID: 28783667
Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer.
Katelyn T Byrne, Courtney B Betts, +26 authors, Robert H Vonderheide.
Clin Cancer Res, 2021 Jun 12; 27(16). PMID: 34112709    Free PMC article.
Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development.
Junke Zheng, Masato Umikawa, +14 authors, Cheng Cheng Zhang.
Nature, 2012 Jun 05; 485(7400). PMID: 22660330    Free PMC article.
Highly Cited.
Antagonistic human FcγRIIB (CD32B) antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo.
Ali Roghanian, Ingrid Teige, +29 authors, Mark S Cragg.
Cancer Cell, 2015 Apr 16; 27(4). PMID: 25873171
Tumor microenvironment-related multigene prognostic prediction model for breast cancer.
Kai Hong, Yingjue Zhang, +3 authors, Yu Guo.
Aging (Albany NY), 2022 Jan 22; 14(2). PMID: 35060926    Free PMC article.
Lysine Acetylation/Deacetylation Modification of Immune-Related Molecules in Cancer Immunotherapy.
Peng Ding, Zhiqiang Ma, +10 authors, Xiaolong Yan.
Front Immunol, 2022 May 20; 13. PMID: 35585975    Free PMC article.
Review.