Clonal replacement of tumor-specific T cells following PD-1 blockade. Kathryn E Yost, Ansuman T Satpathy, +13 authors, Daniel K Wells, Yanyan Qi, Chunlin Wang, Robin Kageyama, Katherine L McNamara, Jeffrey M Granja, Kavita Y Sarin, Ryanne A Brown, Rohit K Gupta, Christina Curtis, Samantha L Bucktrout, Mark M Davis, Anne Lynn S Chang, Howard Y Chang. less Nat Med, 2019 Jul 31; 25(8). PMID: 31359002 Free PMC article. Highly Cited.
|
Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Renier J Brentjens, Isabelle Rivière, +24 authors, Jae H Park, Marco L Davila, Xiuyan Wang, Jolanta Stefanski, Clare Taylor, Raymond Yeh, Shirley Bartido, Oriana Borquez-Ojeda, Malgorzata Olszewska, Yvette Bernal, Hollie Pegram, Mark Przybylowski, Daniel Hollyman, Yelena Usachenko, Domenick Pirraglia, James Hosey, Elmer Santos, Elizabeth Halton, Peter Maslak, David Scheinberg, Joseph Jurcic, Mark Heaney, Glenn Heller, Mark Frattini, Michel Sadelain. less Blood, 2011 Aug 19; 118(18). PMID: 21849486 Free PMC article. Highly Cited.
|
Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy. David B Page, Jianda Yuan, +22 authors, David Redmond, Y Hanna Wen, Jeremy C Durack, Ryan Emerson, Stephen Solomon, Zhiwan Dong, Phillip Wong, Christopher Comstock, Adi Diab, Janice Sung, Majid Maybody, Elizabeth Morris, Edi Brogi, Monica Morrow, Virgilio Sacchini, Olivier Elemento, Harlan Robins, Sujata Patil, James P Allison, Jedd D Wolchok, Clifford Hudis, Larry Norton, Heather L McArthur. less Cancer Immunol Res, 2016 Sep 03; 4(10). PMID: 27587469 Free PMC article.
|
Targeting immune checkpoints in unresectable metastatic cutaneous melanoma: a systematic review and meta-analysis of anti-CTLA-4 and anti-PD-1 agents trials. Seongseok Yun, Nicole D Vincelette, +2 authors, Myke R Green, Andrea E Wahner Hendrickson, Ivo Abraham. less Cancer Med, 2016 May 12; 5(7). PMID: 27167347 Free PMC article. Systematic Review.
|
Preexisting Levels of CD4 T Cells Expressing PD-1 Are Related to Overall Survival in Prostate Cancer Patients Treated with Ipilimumab. Serena S Kwek, Jera Lewis, +7 authors, Li Zhang, Vivian Weinberg, Samantha K Greaney, Andrea L Harzstark, Amy M Lin, Charles J Ryan, Eric J Small, Lawrence Fong. less Cancer Immunol Res, 2015 May 15; 3(9). PMID: 25968455 Free PMC article.
|
Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC. Mark A Socinski, Robert M Jotte, +18 authors, Federico Cappuzzo, Francisco Orlandi, Daniil Stroyakovskiy, Naoyuki Nogami, Delvys Rodríguez-Abreu, Denis Moro-Sibilot, Christian A Thomas, Fabrice Barlesi, Gene Finley, Claudia Kelsch, Anthony Lee, Shelley Coleman, Yu Deng, Yijing Shen, Marcin Kowanetz, Ariel Lopez-Chavez, Alan Sandler, Martin Reck, IMpower150 Study Group. less N Engl J Med, 2018 Jun 05; 378(24). PMID: 29863955 Highly Cited.
|
Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks. D Anderson, J B Bishop, +2 authors, R C Garner, P Ostrosky-Wegman, P B Selby. less Mutat Res, 1995 Aug 01; 330(1-2). PMID: 7623863 Review.
|
Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells. R J North. J Exp Med, 1982 Apr 01; 155(4). PMID: 6460831 Free PMC article. Highly Cited.
|
KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Dietmar Herndler-Brandstetter, Harumichi Ishigame, +13 authors, Ryo Shinnakasu, Valerie Plajer, Carmen Stecher, Jun Zhao, Melanie Lietzenmayer, Lina Kroehling, Akiko Takumi, Kohei Kometani, Takeshi Inoue, Yuval Kluger, Susan M Kaech, Tomohiro Kurosaki, Takaharu Okada, Richard A Flavell. less Immunity, 2018 Apr 08; 48(4). PMID: 29625895 Free PMC article. Highly Cited.
|
Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer. Peter Schmid, Sylvia Adams, +16 authors, Hope S Rugo, Andreas Schneeweiss, Carlos H Barrios, Hiroji Iwata, Véronique Diéras, Roberto Hegg, Seock-Ah Im, Gail Shaw Wright, Volkmar Henschel, Luciana Molinero, Stephen Y Chui, Roel Funke, Amreen Husain, Eric P Winer, Sherene Loi, Leisha A Emens, IMpassion130 Trial Investigators. less N Engl J Med, 2018 Oct 23; 379(22). PMID: 30345906 Highly Cited.
|
A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. Haina Shin, Shawn D Blackburn, +4 authors, Andrew M Intlekofer, Charlly Kao, Jill M Angelosanto, Steven L Reiner, E John Wherry. less Immunity, 2009 Aug 12; 31(2). PMID: 19664943 Free PMC article. Highly Cited.
|
Community detection algorithms: a comparative analysis. Andrea Lancichinetti, Santo Fortunato. Phys Rev E Stat Nonlin Soft Matter Phys, 2010 Apr 07; 80(5 Pt 2). PMID: 20365053 Highly Cited.
|
Regulatory T-cell modulation using cyclophosphamide in vaccine approaches: a current perspective. Dung T Le, Elizabeth M Jaffee. Cancer Res, 2012 Jul 05; 72(14). PMID: 22761338 Free PMC article. Highly Cited. Review.
|
Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma. Hiroyuki Inoue, Jae-Hyun Park, +16 authors, Kazuma Kiyotani, Makda Zewde, Azusa Miyashita, Masatoshi Jinnin, Yukiko Kiniwa, Ryuhei Okuyama, Ryota Tanaka, Yasuhiro Fujisawa, Hiroshi Kato, Akimichi Morita, Jun Asai, Norito Katoh, Kenji Yokota, Masashi Akiyama, Hironobu Ihn, Satoshi Fukushima, Yusuke Nakamura. less Oncoimmunology, 2016 Oct 21; 5(9). PMID: 27757299 Free PMC article.
|
High Levels of Eomes Promote Exhaustion of Anti-tumor CD8+ T Cells. Jing Li, Yi He, +2 authors, Jing Hao, Ling Ni, Chen Dong. less Front Immunol, 2019 Jan 09; 9. PMID: 30619337 Free PMC article.
|
Combination Controversies: Checkpoint Inhibition Alone or in Combination for the Treatment of Melanoma? Allison Betof Warner, Michael A Postow. Oncology (Williston Park), 2018 May 31; 32(5). PMID: 29847853 Review.
|
Medium dose intermittent cyclophosphamide induces immunogenic cell death and cancer cell autonomous type I interferon production in glioma models. Bin Du, David J Waxman. Cancer Lett, 2019 Nov 26; 470. PMID: 31765733 Free PMC article.
|
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. Fernando Cruz-Guilloty, Matthew E Pipkin, +5 authors, Ivana M Djuretic, Ditsa Levanon, Joseph Lotem, Mathias G Lichtenheld, Yoram Groner, Anjana Rao. less J Exp Med, 2009 Jan 14; 206(1). PMID: 19139168 Free PMC article. Highly Cited.
|
Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. J Adam Best, David A Blair, +6 authors, Jamie Knell, Edward Yang, Viveka Mayya, Andrew Doedens, Michael L Dustin, Ananda W Goldrath, Immunological Genome Project Consortium. less Nat Immunol, 2013 Feb 12; 14(4). PMID: 23396170 Free PMC article. Highly Cited.
|
Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. Kuibeom Ko, Sayuri Yamazaki, +7 authors, Kyoko Nakamura, Tomohisa Nishioka, Keiji Hirota, Tomoyuki Yamaguchi, Jun Shimizu, Takashi Nomura, Tsutomu Chiba, Shimon Sakaguchi. less J Exp Med, 2005 Sep 28; 202(7). PMID: 16186187 Free PMC article. Highly Cited.
|
Homeostatic T cell proliferation: how far can T cells be activated to self-ligands? C D Surh, J Sprent. J Exp Med, 2000 Aug 22; 192(4). PMID: 10952731 Free PMC article. Review.
|
Cyclophosphamide induces type I interferon and augments the number of CD44(hi) T lymphocytes in mice: implications for strategies of chemoimmunotherapy of cancer. G Schiavoni, F Mattei, +4 authors, T Di Pucchio, S M Santini, L Bracci, F Belardelli, E Proietti. less Blood, 2000 Mar 09; 95(6). PMID: 10706870
|
CTLA4 blockade broadens the peripheral T-cell receptor repertoire. Lidia Robert, Jennifer Tsoi, +11 authors, Xiaoyan Wang, Ryan Emerson, Blanca Homet, Thinle Chodon, Stephen Mok, Rong Rong Huang, Alistair J Cochran, Begoña Comin-Anduix, Richard C Koya, Thomas G Graeber, Harlan Robins, Antoni Ribas. less Clin Cancer Res, 2014 Mar 04; 20(9). PMID: 24583799 Free PMC article. Highly Cited.
|
Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer. Luis Paz-Ares, Alexander Luft, +20 authors, David Vicente, Ali Tafreshi, Mahmut Gümüş, Julien Mazières, Barbara Hermes, Filiz Çay Şenler, Tibor Csőszi, Andrea Fülöp, Jerónimo Rodríguez-Cid, Jonathan Wilson, Shunichi Sugawara, Terufumi Kato, Ki Hyeong Lee, Ying Cheng, Silvia Novello, Balazs Halmos, Xiaodong Li, Gregory M Lubiniecki, Bilal Piperdi, Dariusz M Kowalski, KEYNOTE-407 Investigators. less N Engl J Med, 2018 Oct 04; 379(21). PMID: 30280635 Highly Cited.
|
Role of GITR in activation response of T lymphocytes. Simona Ronchetti, Giuseppe Nocentini, Carlo Riccardi, Pier Paolo Pandolfi. Blood, 2002 Jun 19; 100(1). PMID: 12070049
|
Regulatory T cells in cancer immunotherapy. Atsushi Tanaka, Shimon Sakaguchi. Cell Res, 2016 Dec 21; 27(1). PMID: 27995907 Free PMC article. Highly Cited. Review.
|
Are Regulatory T Cells Defective in Type 1 Diabetes and Can We Fix Them? Anabelle Visperas, Dario A A Vignali. J Immunol, 2016 Nov 07; 197(10). PMID: 27815439 Free PMC article. Review.
|
Glucocorticoid-induced tumour necrosis factor receptor-related protein: a key marker of functional regulatory T cells. Simona Ronchetti, Erika Ricci, +4 authors, Maria Grazia Petrillo, Luigi Cari, Graziella Migliorati, Giuseppe Nocentini, Carlo Riccardi. less J Immunol Res, 2015 May 12; 2015. PMID: 25961057 Free PMC article. Review.
|
Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Eiji Suzuki, Veena Kapoor, +2 authors, Arminder Singh Jassar, Larry R Kaiser, Steven M Albelda. less Clin Cancer Res, 2005 Sep 17; 11(18). PMID: 16166452 Highly Cited.
|
Validation of hysterectomy indications and the quality assurance process. J C Gambone, J B Lench, +2 authors, M J Slesinski, R C Reiter, J G Moore. less Obstet Gynecol, 1989 Jun 01; 73(6). PMID: 2726108
|
Clinical Application of Anti-CCR4 Monoclonal Antibody. Ryuzo Ueda. Oncology, 2015 Nov 10; 89 Suppl 1. PMID: 26550987 Review.
|
Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients. Edward Cha, Mark Klinger, +4 authors, Yafei Hou, Craig Cummings, Antoni Ribas, Malek Faham, Lawrence Fong. less Sci Transl Med, 2014 May 30; 6(238). PMID: 24871131 Free PMC article. Highly Cited.
|
Unravelling the heterogeneity and dynamic relationships of tumor-infiltrating T cells by single-cell RNA sequencing analysis. Xin Yu, Lei Zhang, +2 authors, Ashutosh Chaudhry, Aaron S Rapaport, Wenjun Ouyang. less J Leukoc Biol, 2020 Apr 10; 107(6). PMID: 32272497 Free PMC article. Review.
|
Rational design of anti-GITR-based combination immunotherapy. Roberta Zappasodi, Cynthia Sirard, +16 authors, Yanyun Li, Sadna Budhu, Mohsen Abu-Akeel, Cailian Liu, Xia Yang, Hong Zhong, Walter Newman, Jingjing Qi, Phillip Wong, David Schaer, Henry Koon, Vamsidhar Velcheti, Matthew D Hellmann, Michael A Postow, Margaret K Callahan, Jedd D Wolchok, Taha Merghoub. less Nat Med, 2019 May 01; 25(5). PMID: 31036879 Free PMC article. Highly Cited.
|
PD-1 blockade induces responses by inhibiting adaptive immune resistance. Paul C Tumeh, Christina L Harview, +23 authors, Jennifer H Yearley, I Peter Shintaku, Emma J M Taylor, Lidia Robert, Bartosz Chmielowski, Marko Spasic, Gina Henry, Voicu Ciobanu, Alisha N West, Manuel Carmona, Christine Kivork, Elizabeth Seja, Grace Cherry, Antonio J Gutierrez, Tristan R Grogan, Christine Mateus, Gorana Tomasic, John A Glaspy, Ryan O Emerson, Harlan Robins, Robert H Pierce, David A Elashoff, Caroline Robert, Antoni Ribas. less Nature, 2014 Nov 28; 515(7528). PMID: 25428505 Free PMC article. Highly Cited.
|
Cyclophosphamide decreases the number, percentage and the function of CD25+ CD4+ regulatory T cells, which suppress induction of contact hypersensitivity. Yuko Ikezawa, Masatoshi Nakazawa, +3 authors, Chizuru Tamura, Kazuo Takahashi, Mutsuhiko Minami, Zenro Ikezawa. less J Dermatol Sci, 2005 May 19; 39(2). PMID: 15899580
|
Comparative transcriptome analysis reveals distinct genetic modules associated with Helios expression in intratumoral regulatory T cells. Kathleen Yates, Kevin Bi, +2 authors, W Nicholas Haining, Harvey Cantor, Hye-Jung Kim. less Proc Natl Acad Sci U S A, 2018 Feb 15; 115(9). PMID: 29440380 Free PMC article.
|
Inhibiting the CD8+ T cell infiltration in the tumor microenvironment after radiotherapy is an important mechanism of radioresistance. Hai-Yan Chen, Lei Xu, +3 authors, Lin-Feng Li, Xiao-Xing Liu, Jian-Xin Gao, Yong-Rui Bai. less Sci Rep, 2018 Aug 11; 8(1). PMID: 30093664 Free PMC article.
|
Immune-potentiating effects of the chemotherapeutic drug cyclophosphamide. Sven Brode, Anne Cooke. Crit Rev Immunol, 2008 Jun 11; 28(2). PMID: 18540827 Review.
|
Clinical evaluation of compounds targeting PD-1/PD-L1 pathway for cancer immunotherapy. Jing Lu, Linda Lee-Gabel, +2 authors, Michelle C Nadeau, Thomas M Ferencz, Scott A Soefje. less J Oncol Pharm Pract, 2014 Jun 12; 21(6). PMID: 24917416 Review.
|
Regulatory T cells in cancer immunosuppression - implications for anticancer therapy. Yosuke Togashi, Kohei Shitara, Hiroyoshi Nishikawa. Nat Rev Clin Oncol, 2019 Feb 02; 16(6). PMID: 30705439 Highly Cited. Review.
|
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Nicholas McGranahan, Andrew J S Furness, +33 authors, Rachel Rosenthal, Sofie Ramskov, Rikke Lyngaa, Sunil Kumar Saini, Mariam Jamal-Hanjani, Gareth A Wilson, Nicolai J Birkbak, Crispin T Hiley, Thomas B K Watkins, Seema Shafi, Nirupa Murugaesu, Richard Mitter, Ayse U Akarca, Joseph Linares, Teresa Marafioti, Jake Y Henry, Eliezer M Van Allen, Diana Miao, Bastian Schilling, Dirk Schadendorf, Levi A Garraway, Vladimir Makarov, Naiyer A Rizvi, Alexandra Snyder, Matthew D Hellmann, Taha Merghoub, Jedd D Wolchok, Sachet A Shukla, Catherine J Wu, Karl S Peggs, Timothy A Chan, Sine R Hadrup, Sergio A Quezada, Charles Swanton. less Science, 2016 Mar 05; 351(6280). PMID: 26940869 Free PMC article. Highly Cited.
|
Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis. Alexandra Snyder, Tavi Nathanson, +18 authors, Samuel A Funt, Arun Ahuja, Jacqueline Buros Novik, Matthew D Hellmann, Eliza Chang, Bulent Arman Aksoy, Hikmat Al-Ahmadie, Erik Yusko, Marissa Vignali, Sharon Benzeno, Mariel Boyd, Meredith Moran, Gopa Iyer, Harlan S Robins, Elaine R Mardis, Taha Merghoub, Jeff Hammerbacher, Jonathan E Rosenberg, Dean F Bajorin. less PLoS Med, 2017 May 30; 14(5). PMID: 28552987 Free PMC article. Highly Cited.
|
Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted. Young H Kim, Su M Shin, +7 authors, Beom K Choi, Ho S Oh, Chang H Kim, Seung J Lee, Kwang H Kim, Don G Lee, Sang H Park, Byoung S Kwon. less J Immunol, 2015 Oct 02; 195(10). PMID: 26423152
|
Molecular Profile of Tumor-Specific CD8+ T Cell Hypofunction in a Transplantable Murine Cancer Model. Katherine A Waugh, Sonia M Leach, +3 authors, Brandon L Moore, Tullia C Bruno, Jonathan D Buhrman, Jill E Slansky. less J Immunol, 2016 Jul 03; 197(4). PMID: 27371726 Free PMC article.
|
Ushering in Integrated T Cell Repertoire Profiling in Cancer. Ning Jiang, Alexandra A Schonnesen, Ke-Yue Ma. Trends Cancer, 2019 Feb 14; 5(2). PMID: 30755308 Free PMC article. Review.
|
BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes. Zachary A Cooper, Dennie T Frederick, +7 authors, Vikram R Juneja, Ryan J Sullivan, Donald P Lawrence, Adriano Piris, Arlene H Sharpe, David E Fisher, Keith T Flaherty, Jennifer A Wargo. less Oncoimmunology, 2013 Nov 20; 2(10). PMID: 24251082 Free PMC article.
|
OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis. Daniel Hirschhorn-Cymerman, Gabrielle A Rizzuto, +6 authors, Taha Merghoub, Adam D Cohen, Francesca Avogadri, Alexander M Lesokhin, Andrew D Weinberg, Jedd D Wolchok, Alan N Houghton. less J Exp Med, 2009 May 06; 206(5). PMID: 19414558 Free PMC article.
|
Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy. Ilenia Aversa, Donatella Malanga, Giuseppe Fiume, Camillo Palmieri. Int J Mol Sci, 2020 Apr 03; 21(7). PMID: 32235561 Free PMC article. Review.
|
Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity. Teresa Ramirez-Montagut, Andrew Chow, +7 authors, Daniel Hirschhorn-Cymerman, Theis H Terwey, Adam A Kochman, Sydney Lu, Randy C Miles, Shimon Sakaguchi, Alan N Houghton, Marcel R M van den Brink. less J Immunol, 2006 May 20; 176(11). PMID: 16709800
|
Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Rachel L Rutishauser, Gislâine A Martins, +6 authors, Sergey Kalachikov, Anmol Chandele, Ian A Parish, Eric Meffre, Joshy Jacob, Kathryn Calame, Susan M Kaech. less Immunity, 2009 Aug 12; 31(2). PMID: 19664941 Free PMC article. Highly Cited.
|
The sensitivity of lymphocytes to ionising radiation. O A TROWELL. J Pathol Bacteriol, 1952 Oct 01; 64(4). PMID: 13000583 Highly Cited.
|
GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability. David A Schaer, Sadna Budhu, +8 authors, Cailian Liu, Campbell Bryson, Nicole Malandro, Adam Cohen, Hong Zhong, Xia Yang, Alan N Houghton, Taha Merghoub, Jedd D Wolchok. less Cancer Immunol Res, 2014 Jan 15; 1(5). PMID: 24416730 Free PMC article. Highly Cited.
|
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Qizhi Tang, Jason Y Adams, +6 authors, Cristina Penaranda, Kristin Melli, Eliane Piaggio, Evridiki Sgouroudis, Ciriaco A Piccirillo, Benoit L Salomon, Jeffrey A Bluestone. less Immunity, 2008 May 13; 28(5). PMID: 18468463 Free PMC article. Highly Cited.
|
The immune contexture in human tumours: impact on clinical outcome. Wolf Herman Fridman, Franck Pagès, Catherine Sautès-Fridman, Jérôme Galon. Nat Rev Cancer, 2012 Mar 16; 12(4). PMID: 22419253 Highly Cited. Review.
|
CD8+ T cell states in human cancer: insights from single-cell analysis. Anne M van der Leun, Daniela S Thommen, Ton N Schumacher. Nat Rev Cancer, 2020 Feb 07; 20(4). PMID: 32024970 Free PMC article. Review.
|
Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing. Xinyi Guo, Yuanyuan Zhang, +16 authors, Liangtao Zheng, Chunhong Zheng, Jintao Song, Qiming Zhang, Boxi Kang, Zhouzerui Liu, Liang Jin, Rui Xing, Ranran Gao, Lei Zhang, Minghui Dong, Xueda Hu, Xianwen Ren, Dennis Kirchhoff, Helge Gottfried Roider, Tiansheng Yan, Zemin Zhang. less Nat Med, 2018 Jun 27; 24(7). PMID: 29942094 Highly Cited.
|
GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo. Ronald W van Olffen, Nathalie Koning, +6 authors, Klaas P J M van Gisbergen, Felix M Wensveen, Robert M Hoek, Louis Boon, Jörg Hamann, Rene A W van Lier, Martijn A Nolte. less J Immunol, 2009 Jun 06; 182(12). PMID: 19494272
|
Immune repertoire: A potential biomarker and therapeutic for hepatocellular carcinoma. Yingxin Han, Hongmei Li, Yanfang Guan, Jian Huang. Cancer Lett, 2015 Jul 19; 379(2). PMID: 26188280 Review.
|
Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells. Willem W Overwijk, Marc R Theoret, +15 authors, Steven E Finkelstein, Deborah R Surman, Laurina A de Jong, Florry A Vyth-Dreese, Trees A Dellemijn, Paul A Antony, Paul J Spiess, Douglas C Palmer, David M Heimann, Christopher A Klebanoff, Zhiya Yu, Leroy N Hwang, Lionel Feigenbaum, Ada M Kruisbeek, Steven A Rosenberg, Nicholas P Restifo. less J Exp Med, 2003 Aug 20; 198(4). PMID: 12925674 Free PMC article. Highly Cited.
|
IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus. Saskia Hemmers, Michail Schizas, +5 authors, Elham Azizi, Stanislav Dikiy, Yi Zhong, Yongqiang Feng, Grégoire Altan-Bonnet, Alexander Y Rudensky. less J Exp Med, 2019 Aug 23; 216(11). PMID: 31434685 Free PMC article.
|
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Jun Shimizu, Sayuri Yamazaki, +2 authors, Takeshi Takahashi, Yasumasa Ishida, Shimon Sakaguchi. less Nat Immunol, 2002 Jan 29; 3(2). PMID: 11812990 Highly Cited.
|
Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1. Thomas A Werfel, David L Elion, +9 authors, Bushra Rahman, Donna J Hicks, Violeta Sanchez, Paula I Gonzales-Ericsson, Mellissa J Nixon, Jamaal L James, Justin M Balko, Peggy A Scherle, Holly K Koblish, Rebecca S Cook. less Cancer Res, 2018 Nov 11; 79(1). PMID: 30413412
|
Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer. Leena Gandhi, Delvys Rodríguez-Abreu, +27 authors, Shirish Gadgeel, Emilio Esteban, Enriqueta Felip, Flávia De Angelis, Manuel Domine, Philip Clingan, Maximilian J Hochmair, Steven F Powell, Susanna Y-S Cheng, Helge G Bischoff, Nir Peled, Francesco Grossi, Ross R Jennens, Martin Reck, Rina Hui, Edward B Garon, Michael Boyer, Belén Rubio-Viqueira, Silvia Novello, Takayasu Kurata, Jhanelle E Gray, John Vida, Ziwen Wei, Jing Yang, Harry Raftopoulos, M Catherine Pietanza, Marina C Garassino, KEYNOTE-189 Investigators. less N Engl J Med, 2018 Apr 17; 378(22). PMID: 29658856 Highly Cited.
|
Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis. Bin Shang, Yao Liu, Shu-juan Jiang, Yi Liu. Sci Rep, 2015 Oct 16; 5. PMID: 26462617 Free PMC article. Highly Cited. Systematic Review.
|
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. Sergio A Quezada, Karl S Peggs, Michael A Curran, James P Allison. J Clin Invest, 2006 Jun 17; 116(7). PMID: 16778987 Free PMC article. Highly Cited.
|
A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Chris Hunter, Raffaella Smith, +52 authors, Daniel P Cahill, Philip Stephens, Claire Stevens, Jon Teague, Chris Greenman, Sarah Edkins, Graham Bignell, Helen Davies, Sarah O'Meara, Adrian Parker, Tim Avis, Syd Barthorpe, Lisa Brackenbury, Gemma Buck, Adam Butler, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Matthew Gorton, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathon Hinton, Andy Jenkinson, David Jones, Vivienne Kosmidou, Ross Laman, Richard Lugg, Andrew Menzies, Janet Perry, Robert Petty, Keiran Raine, David Richardson, Rebecca Shepherd, Alexandra Small, Helen Solomon, Calli Tofts, Jennifer Varian, Sofie West, Sara Widaa, Andy Yates, Douglas F Easton, Gregory Riggins, Jennifer E Roy, Kymberly K Levine, Wolf Mueller, Tracy T Batchelor, David N Louis, Michael R Stratton, P Andrew Futreal, Richard Wooster. less Cancer Res, 2006 Apr 19; 66(8). PMID: 16618716 Free PMC article. Highly Cited.
|
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. Tyler R Simpson, Fubin Li, +11 authors, Welby Montalvo-Ortiz, Manuel A Sepulveda, Katharina Bergerhoff, Frederick Arce, Claire Roddie, Jake Y Henry, Hideo Yagita, Jedd D Wolchok, Karl S Peggs, Jeffrey V Ravetch, James P Allison, Sergio A Quezada. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981 Free PMC article. Highly Cited.
|
Cell Hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics. Marlon Stoeckius, Shiwei Zheng, +5 authors, Brian Houck-Loomis, Stephanie Hao, Bertrand Z Yeung, William M Mauck, Peter Smibert, Rahul Satija. less Genome Biol, 2018 Dec 21; 19(1). PMID: 30567574 Free PMC article. Highly Cited.
|
Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance. Whijae Roh, Pei-Ling Chen, +37 authors, Alexandre Reuben, Christine N Spencer, Peter A Prieto, John P Miller, Vancheswaran Gopalakrishnan, Feng Wang, Zachary A Cooper, Sangeetha M Reddy, Curtis Gumbs, Latasha Little, Qing Chang, Wei-Shen Chen, Khalida Wani, Mariana Petaccia De Macedo, Eveline Chen, Jacob L Austin-Breneman, Hong Jiang, Jason Roszik, Michael T Tetzlaff, Michael A Davies, Jeffrey E Gershenwald, Hussein Tawbi, Alexander J Lazar, Patrick Hwu, Wen-Jen Hwu, Adi Diab, Isabella C Glitza, Sapna P Patel, Scott E Woodman, Rodabe N Amaria, Victor G Prieto, Jianhua Hu, Padmanee Sharma, James P Allison, Lynda Chin, Jianhua Zhang, Jennifer A Wargo, P Andrew Futreal. less Sci Transl Med, 2017 Mar 03; 9(379). PMID: 28251903 Free PMC article. Highly Cited.
|
Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients. François Ghiringhelli, Cedric Menard, +7 authors, Pierre Emmanuel Puig, Sylvain Ladoire, Stephan Roux, François Martin, Eric Solary, Axel Le Cesne, Laurence Zitvogel, Bruno Chauffert. less Cancer Immunol Immunother, 2006 Sep 09; 56(5). PMID: 16960692 Highly Cited.
|
Cyclophosphamide enhances the antitumor efficacy of adoptively transferred immune cells through the induction of cytokine expression, B-cell and T-cell homeostatic proliferation, and specific tumor infiltration. Laura Bracci, Federica Moschella, +8 authors, Paola Sestili, Valentina La Sorsa, Mara Valentini, Irene Canini, Sara Baccarini, Sonia Maccari, Carlo Ramoni, Filippo Belardelli, Enrico Proietti. less Clin Cancer Res, 2007 Jan 27; 13(2 Pt 1). PMID: 17255288
|
CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative. François Ghiringhelli, Nicolas Larmonier, +7 authors, Elise Schmitt, Arnaud Parcellier, Dominique Cathelin, Carmen Garrido, Bruno Chauffert, Eric Solary, Bernard Bonnotte, François Martin. less Eur J Immunol, 2004 Feb 10; 34(2). PMID: 14768038 Highly Cited.
|
Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation. Adam D Cohen, David A Schaer, +10 authors, Cailian Liu, Yanyun Li, Daniel Hirschhorn-Cymmerman, Soo Chong Kim, Adi Diab, Gabrielle Rizzuto, Fei Duan, Miguel A Perales, Taha Merghoub, Alan N Houghton, Jedd D Wolchok. less PLoS One, 2010 May 11; 5(5). PMID: 20454651 Free PMC article. Highly Cited.
|
T-Regulatory Cells In Tumor Progression And Therapy. Amit Verma, Rohit Mathur, +3 authors, Abdullah Farooque, Vandana Kaul, Seema Gupta, Bilikere S Dwarakanath. less Cancer Manag Res, 2020 Jan 11; 11. PMID: 31920383 Free PMC article. Review.
|
Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy. Jae-Hyun Park, Miran Jang, +10 authors, Yunus Emre Tarhan, Toyomasa Katagiri, Mitsunori Sasa, Yasuo Miyoshi, Krishna R Kalari, Vera J Suman, Richard Weinshilboum, Liewei Wang, Judy C Boughey, Matthew P Goetz, Yusuke Nakamura. less Int J Oncol, 2016 Jun 10; 49(2). PMID: 27278091 Free PMC article.
|
High-throughput sequencing of the T-cell receptor repertoire: pitfalls and opportunities. James M Heather, Mazlina Ismail, Theres Oakes, Benny Chain. Brief Bioinform, 2017 Jan 13; 19(4). PMID: 28077404 Free PMC article.
|
Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy. David A Schaer, Daniel Hirschhorn-Cymerman, Jedd D Wolchok. J Immunother Cancer, 2014 May 24; 2. PMID: 24855562 Free PMC article. Review.
|
Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment. Daniel P Cahill, Kymberly K Levine, +9 authors, Rebecca A Betensky, Patrick J Codd, Candice A Romany, Linsey B Reavie, Tracy T Batchelor, P Andrew Futreal, Michael R Stratton, William T Curry, A John Iafrate, David N Louis. less Clin Cancer Res, 2007 Apr 04; 13(7). PMID: 17404084 Free PMC article. Highly Cited.
|
T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection. Marcus Buggert, Johanna Tauriainen, +10 authors, Takuya Yamamoto, Juliet Frederiksen, Martin A Ivarsson, Jakob Michaëlsson, Ole Lund, Bo Hejdeman, Marianne Jansson, Anders Sönnerborg, Richard A Koup, Michael R Betts, Annika C Karlsson. less PLoS Pathog, 2014 Jul 18; 10(7). PMID: 25032686 Free PMC article. Highly Cited.
|
The Diagnostic, Prognostic, and Therapeutic Potential of Adaptive Immune Receptor Repertoire Profiling in Cancer. Lindsay G Cowell. Cancer Res, 2020 Jan 01; 80(4). PMID: 31888887 Review.
|
Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cells. Anna K Nowak, Richard A Lake, +5 authors, Amanda L Marzo, Bernadette Scott, William R Heath, Edward J Collins, Jeffrey A Frelinger, Bruce W S Robinson. less J Immunol, 2003 May 08; 170(10). PMID: 12734333 Highly Cited.
|
A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells. Meromit Singer, Chao Wang, +16 authors, Le Cong, Nemanja D Marjanovic, Monika S Kowalczyk, Huiyuan Zhang, Jackson Nyman, Kaori Sakuishi, Sema Kurtulus, David Gennert, Junrong Xia, John Y H Kwon, James Nevin, Rebecca H Herbst, Itai Yanai, Orit Rozenblatt-Rosen, Vijay K Kuchroo, Aviv Regev, Ana C Anderson. less Cell, 2016 Sep 10; 166(6). PMID: 27610572 Free PMC article. Highly Cited.
|
T cell receptor richness in peripheral blood increases after cetuximab therapy and correlates with therapeutic response. Benjamin A Kansy, Gulidanna Shayan, +8 authors, Hyun-Bae Jie, Sandra P Gibson, Yu L Lei, Sven Brandau, Stephan Lang, Nicole C Schmitt, Fei Ding, Yan Lin, Robert L Ferris. less Oncoimmunology, 2018 Nov 01; 7(11). PMID: 30377562 Free PMC article.
|
Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. Mary Jo Turk, José A Guevara-Patiño, +3 authors, Gabrielle A Rizzuto, Manuel E Engelhorn, Shimon Sakaguchi, Alan N Houghton. less J Exp Med, 2004 Sep 24; 200(6). PMID: 15381730 Free PMC article. Highly Cited.
|
Characterization of the T cell repertoire by deep T cell receptor sequencing in tissues and blood from patients with advanced colorectal cancer. Kenji Tamura, Shoichi Hazama, +8 authors, Rui Yamaguchi, Seiya Imoto, Hiroko Takenouchi, Yuka Inoue, Shinsuke Kanekiyo, Yoshitaro Shindo, Satoru Miyano, Yusuke Nakamura, Kazuma Kiyotani. less Oncol Lett, 2016 Jun 11; 11(6). PMID: 27284367 Free PMC article.
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