Journal Article
. 1994 Jun; 343(8910):1405-10.
doi: 10.1016/s0140-6736(94)92529-1.

Factors influencing the natural history of colorectal liver metastases

R Stangl 1 A Altendorf-Hofmann  R M Charnley  J Scheele  
  • PMID: 7515134
  •     181 citations


Palliative treatment of unresectable colorectal liver metastases is common and often justified with reference to historical data on the natural history of the disease. However, in view of the improved diagnostic accuracy of modern imaging techniques, these previously published series do not provide sufficient guidance to judge the prognostic efficacy of palliative treatment. In the late 1970s we started prospectively to collect data on consecutive patients with colorectal liver metastases according to a standard protocol. We now present data derived from this series on factors that may affect outcome in untreated patients. Between January, 1980, and December, 1990, 1099 consecutive patients were recorded, of whom 566 (51.5%) received no treatment for their hepatic tumour. Excluding 34 early deaths and 48 patients with a second malignant tumour, 484 patients provided the basis for analysis. All patients were followed up to July 1, 1993, or death. At the closing date of the study only 1 untreated patient was still alive. The impact of various factors on survival was analysed by univariate and multivariate analyses. Six independent determinants of survival were identified in the following order: percentage liver volume replaced by tumour (LVRT), grade of malignancy of the primary tumour, presence of extrahepatic disease, mesenteric lymph-node involvement, serum carcino-embryonic antigen, and age. The subsequent combination of the independently significant factors, separately for patients with up to or more than 25% LVRT, yielded a prognostic tree that displayed median survival times of various subgroups of 3.8 to 21.3 months. These findings provide a framework to estimate the survival expectancy of untreated patients, thereby allowing improved assessment of the prognostic significance of palliative therapeutic approaches.

Colorectal liver metastases.
D Burke, T G Allen-Mersh.
Postgrad Med J, 1996 Aug 01; 72(850). PMID: 8796208    Free PMC article.
Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy.
H Bismuth, R Adam, +5 authors, L Engerran.
Ann Surg, 1996 Oct 01; 224(4). PMID: 8857855    Free PMC article.
Highly Cited.
Primary resection and synchronous regional hepatic chemotherapy or cryotherapy for colorectal cancer with liver metastases.
V Dasappa, W B Ross, +3 authors, D L Morris.
Int J Colorectal Dis, 1996 Jan 01; 11(1). PMID: 8919340
Place of cryosurgery in the treatment of malignant liver tumors.
R Adam, E Akpinar, +3 authors, H Bismuth.
Ann Surg, 1997 Jan 01; 225(1). PMID: 8998119    Free PMC article.
Isolated hepatic perfusion in the pig with TNF-alpha with and without melphalan.
I H Borel Rinkes, M R de Vries, +5 authors, A M Eggermont.
Br J Cancer, 1997 Jan 01; 75(10). PMID: 9166936    Free PMC article.
Influence of metastatic site as an additional predictor for response and outcome in advanced colorectal carcinoma.
L Assersohn, A Norman, +3 authors, J Oates.
Br J Cancer, 1999 Apr 17; 79(11-12). PMID: 10206296    Free PMC article.
Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer: long-term results.
M Minagawa, M Makuuchi, +5 authors, H Imamura.
Ann Surg, 2000 Apr 05; 231(4). PMID: 10749608    Free PMC article.
Highly Cited.
Oxaliplatin. A review of its pharmacological properties and clinical efficacy in metastatic colorectal cancer and its potential in other malignancies.
C R Culy, D Clemett, L R Wiseman.
Drugs, 2000 Nov 21; 60(4). PMID: 11085200
Hepatic resection for colorectal liver metastases: A cost-effectiveness analysis.
S M Beard, M Holmes, C Price, A W Majeed.
Ann Surg, 2000 Nov 23; 232(6). PMID: 11088071    Free PMC article.
Selective internal radiation therapy with 90yttrium microspheres for extensive colorectal liver metastases.
R S Stubbs, R J Cannan, A W Mitchell.
J Gastrointest Surg, 2001 May 22; 5(3). PMID: 11360053
Treatment of colorectal metastases: surgery, cryotherapy, or radiofrequency ablation.
J N Primrose.
Gut, 2002 Jan 05; 50(1). PMID: 11772955    Free PMC article.
CT-guided intratumoural administration of cisplatin/epinephrine gel for treatment of malignant liver tumours.
T J Vogl, K Engelmann, +5 authors, E Orenberg.
Br J Cancer, 2002 Mar 01; 86(4). PMID: 11870531    Free PMC article.
Clinical short-term results of radiofrequency ablation in liver cancers.
Hong-Chi Jiang, Lian-Xin Liu, +6 authors, Lin-Feng Wu.
World J Gastroenterol, 2002 Aug 14; 8(4). PMID: 12174368    Free PMC article.
Cost-effectiveness of hepatic metastasectomy in patients with metastatic colorectal carcinoma: a state-transition Monte Carlo decision analysis.
G Scott Gazelle, M G Myriam Hunink, +6 authors, Milton C Weinstein.
Ann Surg, 2003 Apr 05; 237(4). PMID: 12677152    Free PMC article.
The histological features of microwave coagulation therapy: an assessment of a new applicator design.
Benjamin Swift, Andrew Strickland, +3 authors, David Lloyd.
Int J Exp Pathol, 2003 Apr 16; 84(1). PMID: 12694484    Free PMC article.
Treatment of advanced rectal cancer in a patient after combined pancreas-kidney transplantation.
T T Zittel, C F R Mehl, +2 authors, E C Jehle.
Langenbecks Arch Surg, 2003 Oct 24; 389(1). PMID: 14574576
Liver resection for colorectal metastases: the third hepatectomy.
René Adam, Gérard Pascal, +3 authors, Henri Bismuth.
Ann Surg, 2003 Nov 25; 238(6). PMID: 14631224    Free PMC article.
The role of lymphadenectomy for liver tumors: further considerations on the appropriateness of treatment strategy.
Giorgio Ercolani, Gian Luca Grazi, +5 authors, Antonino Cavallari.
Ann Surg, 2004 Jan 28; 239(2). PMID: 14745328    Free PMC article.
[Radiofrequency ablation of liver metastases].
P L Pereira, S Clasen, +6 authors, C D Claussen.
Radiologe, 2004 Mar 26; 44(4). PMID: 15042292
p53 and HLA class-I expression are not down-regulated in colorectal cancer liver metastases.
Anand G Menon, Rob A E M Tollenaar, +5 authors, Peter J K Kuppen.
Clin Exp Metastasis, 2004 Apr 07; 21(1). PMID: 15065606
Hepatic resection in stage IV colorectal cancer: prognostic predictors of outcome.
Adriano Tocchi, Gianluca Mazzoni, +3 authors, Elia Bettelli.
Int J Colorectal Dis, 2004 Apr 23; 19(6). PMID: 15103491
[Transarterial chemoembolization of liver metastases of colorectal carcinoma using degradable starch microspheres (Spherex): personal investigations and review of the literature].
K Wasser, F Giebel, +2 authors, P Landwehr.
Radiologe, 2004 Aug 19; 45(7). PMID: 15316615
Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival.
René Adam, Valérie Delvart, +9 authors, Henri Bismuth.
Ann Surg, 2004 Sep 24; 240(4). PMID: 15383792    Free PMC article.
Highly Cited.
First and repeat resection of colorectal liver metastases in elderly patients.
Thomas Zacharias, Daniel Jaeck, +2 authors, Jean-Christophe Weber.
Ann Surg, 2004 Oct 20; 240(5). PMID: 15492569    Free PMC article.
Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases?
René Adam, Gerard Pascal, +5 authors, Henri Bismuth.
Ann Surg, 2004 Dec 01; 240(6). PMID: 15570210    Free PMC article.
Highly Cited.
Fas/CD95 signaling rather than angiogenesis or proliferative activity is a useful prognostic factor in patients with resected liver metastases from colorectal cancer.
Hisashi Onodera, Akira Mori, +4 authors, Tatsuaki Tsuruyama.
Int J Colorectal Dis, 2005 Apr 23; 20(6). PMID: 15846499
Short- and-long term results of intraoperative radiofrequency ablation of liver metastases.
G Navarra, A Ayav, +5 authors, L R Jiao.
Int J Colorectal Dis, 2005 May 03; 20(6). PMID: 15864606
Liver resection after irinotecan, 5-fluorouracil, and folinic acid for patients with unresectable colorectal liver metastases: a multicenter phase II study by the Cancer Therapeutic Research Group.
Wing M Ho, B Ma, +8 authors, A T C Chan.
Med Oncol, 2005 Aug 20; 22(3). PMID: 16110141
Liver metastases of colorectal cancer: US, CT or MR?
Wolfgang Schima, Christiane Kulinna, Herbert Langenberger, Ahmed Ba-Ssalamah.
Cancer Imaging, 2005 Dec 20; 5 Spec No A. PMID: 16361131    Free PMC article.
Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies.
P C Simmonds, J N Primrose, +3 authors, M Rees.
Br J Cancer, 2006 Mar 16; 94(7). PMID: 16538219    Free PMC article.
Highly Cited. Systematic Review.
Guidelines for resection of colorectal cancer liver metastases.
O J Garden, M Rees, +5 authors, R W Parks.
Gut, 2006 Jul 13; 55 Suppl 3. PMID: 16835351    Free PMC article.
Highly Cited.
Radiofrequency ablation in patients with primary and secondary hepatic malignancies.
V E de Meijer, C Verhoef, +3 authors, J N M Ijzermans.
J Gastrointest Surg, 2006 Jul 18; 10(7). PMID: 16843866
Hepatic resection for noncolorectal nonendocrine liver metastases: analysis of 1,452 patients and development of a prognostic model.
René Adam, Laurence Chiche, +10 authors, Association Française de Chirurgie.
Ann Surg, 2006 Sep 26; 244(4). PMID: 16998361    Free PMC article.
Highly Cited.
Natural history of liver metastases from colorectal carcinoma.
J Norstein, W Silen.
J Gastrointest Surg, 2006 Oct 25; 1(5). PMID: 17061331
FDG-PET in colorectal cancer.
Lioe-Fee de Geus-Oei, Theo J M Ruers, +3 authors, Wim J G Oyen.
Cancer Imaging, 2006 Nov 23; 6. PMID: 17114081    Free PMC article.
Safe liver resection following chemotherapy for colorectal metastases is a matter of timing.
F K S Welsh, H S Tilney, +2 authors, M Rees.
Br J Cancer, 2007 Mar 14; 96(7). PMID: 17353923    Free PMC article.
Actual role of radiofrequency ablation of liver metastases.
Philippe L Pereira.
Eur Radiol, 2007 Apr 13; 17(8). PMID: 17429644
When professional opinion is not enough.
Tom Treasure, Martin Utley, Ian Hunt.
BMJ, 2007 Apr 21; 334(7598). PMID: 17446615    Free PMC article.
Concepts and preliminary data toward the realization of image-guided liver surgery.
David M Cash, Michael I Miga, +5 authors, William C Chapman.
J Gastrointest Surg, 2007 Apr 27; 11(7). PMID: 17458587    Free PMC article.
Liver resection for primarily unresectable colorectal metastases downsized by chemotherapy.
Gennaro Nuzzo, Felice Giuliante, +5 authors, Carlo Barone.
J Gastrointest Surg, 2007 Apr 27; 11(3). PMID: 17458605
Chemotherapy-induced normalization of FDG uptake by colorectal liver metastases does not usually indicate complete pathologic response.
Marcus C B Tan, David C Linehan, +2 authors, Steven M Strasberg.
J Gastrointest Surg, 2007 Jul 12; 11(9). PMID: 17623263
Histological, CT, and intraoperative ultrasound appearance of hepatic tumors previously treated by laparoscopic radiofrequency ablation.
T Mason, E Berber, J C Graybill, A Siperstein.
J Gastrointest Surg, 2007 Jul 27; 11(10). PMID: 17653812
Pulmonary metastasectomy: a common practice based on weak evidence.
Tom Treasure.
Ann R Coll Surg Engl, 2007 Nov 15; 89(8). PMID: 17999813    Free PMC article.
Predictors of survival after hepatic resection among patients with colorectal liver metastasis.
X Wang, D L Hershman, +4 authors, A I Neugut.
Br J Cancer, 2007 Dec 12; 97(12). PMID: 18071347    Free PMC article.
A cost-utility analysis of treatments for malignant liver tumours: a pilot project.
Andrew McKay, Trish Kutnikoff, Mark Taylor.
HPB (Oxford), 2008 Mar 12; 9(1). PMID: 18333112    Free PMC article.
Gastroduodenal ulceration following hepatic arterial chemotherapy: the role of methylene blue endoscopy in the investigation of pain.
M L Talbot, J R Clark, P C Clingan, D L Morris.
HPB (Oxford), 2008 Mar 12; 4(1). PMID: 18333149    Free PMC article.
Lung metastases after liver resection or cryotherapy for hepatic metastasis from colorectal cancer--there is a difference!
T D Yan, G Chiang, +2 authors, D L Morris.
HPB (Oxford), 2008 Mar 12; 8(2). PMID: 18333260    Free PMC article.
The case for neo-adjuvant chemotherapy. For.
Hassan Z Malik.
Ann R Coll Surg Engl, 2008 Sep 09; 90(6). PMID: 18777621    Free PMC article.
Critical questions in the imaging of colorectal hepatic metastases.
Dow-Mu Koh, Jonathan Berry.
Cancer Imaging, 2008 Oct 15; 8 Spec No A. PMID: 18852083    Free PMC article.
Alteration of Drug Sensitivity in Human Colon Cancer Cells after Exposure to Heat: Implications for Liver Metastasis Therapy using RFA and Chemotherapy.
Ryouji Makizumi, Weng-Lang Yang, +2 authors, T S Ravikumar.
Int J Clin Exp Med, 2008 Dec 17; 1(2). PMID: 19079666    Free PMC article.
Local treatment for recurrent colorectal hepatic metastases after partial hepatectomy.
Anne E M van der Pool, Z S Lalmahomed, +3 authors, Cornelis Verhoef.
J Gastrointest Surg, 2009 Jan 10; 13(5). PMID: 19132450
Immunotherapy for liver tumors: present status and future prospects.
Pablo Matar, Laura Alaniz, +7 authors, Guillermo Mazzolini.
J Biomed Sci, 2009 Mar 11; 16. PMID: 19272130    Free PMC article.
Accomplishments in 2007 in the management of curable metastatic colorectal cancer.
Amit Shah, Steven Alberts, René Adam.
Gastrointest Cancer Res, 2009 Apr 09; 2(3 Suppl). PMID: 19352462    Free PMC article.
Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy--a case report.
Valeria Milani, Stefan Stangl, +7 authors, Gabriele Multhoff.
J Transl Med, 2009 Jun 25; 7. PMID: 19549307    Free PMC article.
The prognostic significance of the preoperative full blood count after resection of colorectal liver metastases.
K Dajani, D A O'Reilly, +3 authors, A Wu.
HPB Surg, 2009 Sep 15; 2009. PMID: 19750237    Free PMC article.
Accomplishments in 2008 in the management of curable metastatic colorectal cancer.
René Adam, Emir Hoti, Gunnar Folprecht, Al B Benson.
Gastrointest Cancer Res, 2009 Dec 17; 3(5 Supplement 2). PMID: 20011559    Free PMC article.
Assessment of liver metastases from colorectal adenocarcinoma following chemotherapy: SPIO-MRI versus FDG-PET/CT.
L Bacigalupo, S Aufort, +3 authors, B Gallix.
Radiol Med, 2010 Jun 25; 115(7). PMID: 20574703
Adjuvant oxaliplatin- or irinotecan-containing chemotherapy improves overall survival following resection of metachronous colorectal liver metastases.
Jin-Hwang Liu, Yao-Yu Hsieh, +7 authors, Jen-Kou Lin.
Int J Colorectal Dis, 2010 Jun 25; 25(10). PMID: 20574727    Free PMC article.
Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases.
Eleanor I Ager, Way W Chong, Shu-Wen Wen, Christopher Christophi.
Cancer Cell Int, 2010 Jun 30; 10. PMID: 20584290    Free PMC article.
Open liver resection for colorectal metastases: better short- and long-term outcomes in patients potentially suitable for laparoscopic liver resection.
Fenella K S Welsh, Paris P Tekkis, Timothy G John, Myrddin Rees.
HPB (Oxford), 2010 Jul 02; 12(3). PMID: 20590886    Free PMC article.
Simultaneous liver and colorectal resections are safe for synchronous colorectal liver metastases.
Yanxin Luo, Lei Wang, +8 authors, Jianping Wang.
J Gastrointest Surg, 2010 Aug 03; 14(12). PMID: 20676791
The role of adjuvant pelvic radiotherapy in rectal cancer with synchronous liver metastasis: a retrospective study.
Jun Won Kim, Yong Bae Kim, +6 authors, Ki Chang Keum.
Radiat Oncol, 2010 Sep 02; 5. PMID: 20804559    Free PMC article.
Neoadjuvant chemotherapy affects staging of colorectal liver metastasis--a comparison of PET, CT and intraoperative ultrasound.
Johann Spatz, G Holl, +3 authors, B Märkl.
Int J Colorectal Dis, 2010 Oct 21; 26(2). PMID: 20960208
Advances in therapeutics for liver metastasis from colorectal cancer.
Akira Kobayashi, Shinichi Miyagawa.
World J Gastrointest Oncol, 2010 Dec 17; 2(10). PMID: 21160889    Free PMC article.
Anatomical versus nonanatomical resection of colorectal liver metastases: is there a difference in surgical and oncological outcome?
Zarina S Lalmahomed, Ninos Ayez, +3 authors, Cornelis Verhoef.
World J Surg, 2010 Dec 17; 35(3). PMID: 21161655    Free PMC article.
Expression of osteopontin coregulators in primary colorectal cancer and associated liver metastases.
D J Mole, C O'Neill, +6 authors, F C Campbell.
Br J Cancer, 2011 Feb 24; 104(6). PMID: 21343932    Free PMC article.
Clinical reports of pulmonary metastasectomy for colorectal cancer: a citation network analysis.
F Fiorentino, C Vasilakis, T Treasure.
Br J Cancer, 2011 Mar 10; 104(7). PMID: 21386844    Free PMC article.
Factors that influence survival in unresectable metastatic or locally advanced colorectal cancer.
Chao-Wen Hsu, Tai-Ming King, Hsin-Tai Wang, Jui-Ho Wang.
Int J Colorectal Dis, 2011 May 17; 26(12). PMID: 21573902
The added value of contrast-enhanced ultrasound in patients with colorectal cancer undergoing preoperative evaluation with extensive gadobenate dimeglumine liver MRI.
Nikolaos Kartalis, Torkel B Brismar, +2 authors, Nils Albiin.
Eur Radiol, 2011 May 28; 21(10). PMID: 21617893
Determinants of short- and long-term outcome in patients undergoing simultaneous resection of colorectal cancer and synchronous colorectal liver metastases.
C S D Roxburgh, C H Richards, +3 authors, P G Horgan.
Int J Colorectal Dis, 2011 Nov 17; 27(3). PMID: 22086199
Safety of hepatic resection for colorectal metastases in the era of neo-adjuvant chemotherapy.
Alessandro Cucchetti, Giorgio Ercolani, +5 authors, Antonio Daniele Pinna.
Langenbecks Arch Surg, 2011 Dec 27; 397(3). PMID: 22198370
Pyogenic liver abscess as initial presentation in locally advanced right colon cancer invading the liver, gallbladder, and duodenum.
Kai Qu, Chang Liu, +4 authors, Yi Lv.
Front Med, 2011 Dec 27; 5(4). PMID: 22198755
An update on chemotherapy of colorectal liver metastases.
Chen-Chen Wang, Jin Li.
World J Gastroenterol, 2012 Jan 10; 18(1). PMID: 22228967    Free PMC article.
Resection of colorectal liver metastases following neoadjuvant chemotherapy.
A Chiappa, E Bertani, +10 authors, B Andreoni.
Ecancermedicalscience, 2007 Jan 01; 1. PMID: 22275956    Free PMC article.
Diagnostic performance of MDCT, PET/CT and gadoxetic acid (Primovist(®))-enhanced MRI in patients with colorectal liver metastases being considered for hepatic resection: initial experience in a single centre.
V O Chan, J P Das, +5 authors, D E Malone.
Ir J Med Sci, 2012 Mar 20; 181(4). PMID: 22426901
Long-term outcome of radiofrequency thermal ablation (RFA) of liver metastases from colorectal cancer (CRC): size as the leading prognostic factor for survival.
A Veltri, T Guarnieri, +4 authors, P Racca.
Radiol Med, 2012 Mar 21; 117(7). PMID: 22430677
Resectability of colorectal liver metastases: an evolving definition.
Flavio G Rocha, W Scott Helton.
HPB (Oxford), 2012 Apr 11; 14(5). PMID: 22487064    Free PMC article.
Detailed liver-specific imaging prior to pre-operative chemotherapy for colorectal liver metastases reduces intra-hepatic recurrence and the need for a repeat hepatectomy.
Brett Knowles, Fenella K S Welsh, +2 authors, Myrddin Rees.
HPB (Oxford), 2012 Apr 11; 14(5). PMID: 22487067    Free PMC article.
Radiofrequency ablation for colorectal liver metastases: prognostic factors in non-surgical candidates.
Ayumi Hamada, Koichiro Yamakado, +7 authors, Kan Takeda.
Jpn J Radiol, 2012 Jun 06; 30(7). PMID: 22664831
Colorectal liver metastases; the current scenario.
Samir Pathak, Graeme J Poston.
Indian J Surg Oncol, 2010 Dec 01; 1(4). PMID: 22693391    Free PMC article.
Impact of simultaneous diaphragm resection during hepatectomy for treatment of metastatic colorectal cancer.
George Z Li, Ryan S Turley, +3 authors, Bryan M Clary.
J Gastrointest Surg, 2012 Jun 29; 16(8). PMID: 22739844
Chemotherapy-associated liver injury in patients with colorectal liver metastases: a systematic review and meta-analysis.
Stuart M Robinson, Colin H Wilson, +2 authors, Steven A White.
Ann Surg Oncol, 2012 Jul 07; 19(13). PMID: 22766981    Free PMC article.
Systematic Review.
First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI).
K Eichler, S Zangos, +4 authors, T J Vogl.
Int J Oncol, 2012 Jul 31; 41(4). PMID: 22842404    Free PMC article.
Hepatic resection combined with radiofrequency ablation for initially unresectable colorectal liver metastases after effective chemotherapy is a safe procedure with a low incidence of local recurrence.
Kosuke Mima, Toru Beppu, +9 authors, Hideo Baba.
Int J Clin Oncol, 2012 Sep 04; 18(5). PMID: 22940848
Repeated Liver Resection for Colorectal Liver Metastases: A Comparison with Primary Liver Resections concerning Perioperative and Long-Term Outcome.
Kristoffer Jönsson, Gerd Gröndahl, +2 authors, Roland Andersson.
Gastroenterol Res Pract, 2012 Sep 14; 2012. PMID: 22973305    Free PMC article.
Colorectal liver metastases.
Ching-Wei D Tzeng, Thomas A Aloia.
J Gastrointest Surg, 2012 Oct 12; 17(1). PMID: 23054896
Successful combination therapy of radical liver resection with 5-fluorouracil/leucovorin, oxaliplatin, plus bevacizumab for ascending colon cancer with pulmonary and 43 liver metastases: report of a case.
Takanori Ochiai, Taiki Masuda, +12 authors, Shigeru Yamazaki.
Int Surg, 2012 Oct 30; 97(1). PMID: 23101994    Free PMC article.
Feasibility and potential benefit of preoperative chemotherapy for colorectal liver metastasis (CLM): a single-centered retrospective study.
Kozo Kataoka, Akiyoshi Kanazawa, +3 authors, Yukihiro Kohno.
Surg Today, 2012 Nov 10; 43(10). PMID: 23139049
Preoperative treatment with bevacizumab in combination with chemotherapy in patients with unresectable metastatic colorectal carcinoma.
J Figueras, S Lopez-Ben, +6 authors, B Queralt.
Clin Transl Oncol, 2012 Nov 13; 15(6). PMID: 23143951
Survival after liver resection in metastatic colorectal cancer: review and meta-analysis of prognostic factors.
Gena P Kanas, Aliki Taylor, +6 authors, Graeme Poston.
Clin Epidemiol, 2012 Nov 16; 4. PMID: 23152705    Free PMC article.
Highly Cited.
Clinical and prognostic usefulness of serum proteomic profile in hepatic colorectal metastases: a pilot prospective study.
J Martí, J Fuster, +7 authors, J C García-Valdecasas.
Clin Transl Oncol, 2013 Jan 31; 15(9). PMID: 23361307
Prognostic value of serum neutrophil gelatinase-associated lipocalin in metastatic and nonmetastatic colorectal cancer.
Josep Martí, Josep Fuster, +7 authors, Juan Carlos García-Valdecasas.
World J Surg, 2013 Feb 08; 37(5). PMID: 23389669
Repeat liver resection for recurrent colorectal metastases: a single-centre, 13-year experience.
Narendra Battula, Dimitrios Tsapralis, +6 authors, Ravi Marudanayagam.
HPB (Oxford), 2013 Mar 28; 16(2). PMID: 23530978    Free PMC article.
Hepatic histopathology and postoperative outcome after preoperative chemotherapy for Chinese patients with colorectal liver metastases.
Qi-Ying Lu, Ai-Lian Zhao, +2 authors, Lin Shen.
World J Gastrointest Surg, 2013 Apr 05; 5(3). PMID: 23556058    Free PMC article.
Modern prospection for hepatic arterial infusion chemotherapy in malignancies with liver metastases.
Yi-Hsin Liang, Yu-Yun Shao, +3 authors, Zhong-Zhe Lin.
Int J Hepatol, 2013 May 22; 2013. PMID: 23691329    Free PMC article.
Management of potentially resectable colorectal cancer liver metastases.
Fausto Meriggi, Paola Bertocchi, Alberto Zaniboni.
World J Gastrointest Surg, 2013 May 28; 5(5). PMID: 23710291    Free PMC article.
Liver resection for colorectal cancer metastases.
S Gallinger, J J Biagi, +3 authors, R S McLeod.
Curr Oncol, 2013 Jun 06; 20(3). PMID: 23737695    Free PMC article.
Microwave ablation of liver metastases to overcome the limitations of radiofrequency ablation.
Anna Maria Ierardi, Chiara Floridi, +7 authors, Gianpaolo Carrafiello.
Radiol Med, 2013 Jul 31; 118(6). PMID: 23892957
In vivo assessment of intratumoral aspirin injection to treat hepatic tumors.
Rogério Saad-Hossne, Fábio Vieira Teixeira, Rafael Denadai.
World J Hepatol, 2013 Jul 31; 5(7). PMID: 23898370    Free PMC article.
Collagen peptides in urine: a new promising biomarker for the detection of colorectal liver metastases.
Mirelle E E Bröker, Zarina S Lalmahomed, +6 authors, Theo M Luider.
PLoS One, 2013 Aug 27; 8(8). PMID: 23976965    Free PMC article.
The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome.
S M Robinson, D A Mann, +3 authors, S A White.
Br J Cancer, 2013 Oct 12; 109(9). PMID: 24113143    Free PMC article.
Does "conversion chemotherapy" really improve survival in metastatic colorectal cancer patients with liver-limited disease?
K Kataoka, A Kanazawa, +3 authors, A Arimoto.
World J Surg, 2013 Oct 30; 38(4). PMID: 24166026
Selective Interarterial Radiation Therapy (SIRT) in Colorectal Liver Metastases: How Do We Monitor Response?
D Hipps, F Ausania, +2 authors, J J French.
HPB Surg, 2013 Nov 29; 2013. PMID: 24285916    Free PMC article.
[Neoadjuvant chemotherapy or primary surgery for colorectal liver metastases. Pro primary surgery].
S Heinrich, H Lang.
Chirurg, 2013 Dec 18; 85(1). PMID: 24337153
Selection criteria for combined resection of synchronous colorectal cancer hepatic metastases: a cautionary note.
Shaun P McKenzie, H David Vargas, B Mark Evers, Daniel L Davenport.
Int J Colorectal Dis, 2014 Jan 15; 29(6). PMID: 24414017
Tissue-based biomarkers predicting outcomes in metastatic colorectal cancer: a review.
L Ung, A K-Y Lam, D L Morris, T C Chua.
Clin Transl Oncol, 2014 Jan 25; 16(5). PMID: 24458880
Safety of redo hepatectomy for colorectal liver metastases after selective interarterial radiation therapy: a case report.
Kyriakos Neofytou, Harpreet Wasan, Satvinder Mudan.
Case Rep Surg, 2014 Apr 10; 2014. PMID: 24716079    Free PMC article.
MicroRNA-224 suppresses colorectal cancer cell migration by targeting Cdc42.
Tao-Wei Ke, Han-Lin Hsu, +3 authors, Chao-Wen Cheng.
Dis Markers, 2014 May 13; 2014. PMID: 24817781    Free PMC article.
Effect of M1a and M1b category in metastatic colorectal cancer.
Hagen Kennecke, Jason Yu, +4 authors, Ryan Woods.
Oncologist, 2014 Jun 06; 19(7). PMID: 24899642    Free PMC article.
Relationships between KRAS mutation status and baseline radiographic distribution of disease in patients with stage IV colorectal cancer.
Michael H Rosenthal, Kyung Won Kim, +2 authors, Nikhil H Ramaiya.
Abdom Imaging, 2014 Jun 08; 39(6). PMID: 24906690    Free PMC article.
Cryoablation plus chemotherapy in colorectal cancer patients with liver metastases.
Zhiwei Li, Yujiao Fu, +4 authors, Yanqiao Zhang.
Tumour Biol, 2014 Aug 02; 35(11). PMID: 25081377
Surgical management of colorectal cancer metastases to the liver: multimodality approach and a single institutional experience.
Aaron U Blackham, Katrina Swett, Edward A Levine, Perry Shen.
Colorectal Cancer, 2013 Feb 01; 2(1). PMID: 25110522    Free PMC article.
Pulmonary Metastasectomy for Colorectal Cancer: Recent Reports Prompt a Review of the Available Evidence.
Tom Treasure.
Curr Colorectal Cancer Rep, 2014 Sep 06; 10(3). PMID: 25191154    Free PMC article.
CT predictors of overall survival at initial diagnosis in patients with stage IV colorectal cancer.
Michael H Rosenthal, Kyung Won Kim, +2 authors, Nikhil H Ramaiya.
Abdom Imaging, 2014 Oct 19; 40(5). PMID: 25326260    Free PMC article.
History and present status of pulmonary metastasectomy in colorectal cancer.
Tom Treasure, Mišel Milošević, Francesca Fiorentino, Joachim Pfannschmidt.
World J Gastroenterol, 2014 Oct 31; 20(40). PMID: 25356017    Free PMC article.
"Vanishing liver metastases"-A real challenge for liver surgeons.
Alex Zendel, Eylon Lahat, +3 authors, Arie Ariche.
Hepatobiliary Surg Nutr, 2014 Nov 14; 3(5). PMID: 25392841    Free PMC article.
Strategies for Management of Synchronous Colorectal Metastases.
Jason A Castellanos, Nipun B Merchant.
Curr Surg Rep, 2014 Nov 29; 2. PMID: 25431745    Free PMC article.
Novel methods for clinical risk stratification in patients with colorectal liver metastases.
Ki-Yeol Kim, Nam Kyu Kim, +10 authors, Sang Joon Shin.
Cancer Res Treat, 2014 Dec 09; 47(2). PMID: 25483744    Free PMC article.
Selective Internal Radiation Therapy (SIRT) with yttrium-90 resin microspheres plus standard systemic chemotherapy regimen of FOLFOX versus FOLFOX alone as first-line treatment of non-resectable liver metastases from colorectal cancer: the SIRFLOX study.
Peter Gibbs, Val Gebski, +4 authors, SIRFLOX Study Group.
BMC Cancer, 2014 Dec 10; 14. PMID: 25487708    Free PMC article.
Weichang'an and 5-fluorouracil suppresses colorectal cancer in a mouse model.
Li Tao, Jin-Kun Yang, +4 authors, Ying-Jie Zhu.
World J Gastroenterol, 2015 Jan 30; 21(4). PMID: 25632185    Free PMC article.
Tumour growth of colorectal rat liver metastases is inhibited by hepatic arterial infusion of the mTOR-inhibitor temsirolimus after portal branch ligation.
Jens Sperling, Christian Ziemann, +3 authors, Otto Kollmar.
Clin Exp Metastasis, 2015 Feb 20; 32(4). PMID: 25693517
Nomogram including pretherapeutic parameters for prediction of survival after SIRT of hepatic metastases from colorectal cancer.
Wolfgang Peter Fendler, Harun Ilhan, +7 authors, Alexander R Haug.
Eur Radiol, 2015 Feb 28; 25(9). PMID: 25721320
Laparoscopic Simultaneous Resection of Colorectal Primary Tumor and Liver Metastases: Results of a Multicenter International Study.
Stefano Ferretti, Hadrien Tranchart, +13 authors, Ibrahim Dagher.
World J Surg, 2015 Mar 31; 39(8). PMID: 25813824
Cancer Treatment: The Cost Factor.
S Smith.
West Indian Med J, 2015 Apr 14; 63(7). PMID: 25867563    Free PMC article.
Proposal for novel histological findings of colorectal liver metastases with preoperative chemotherapy.
Kazuyuki Ishida, Noriyuki Uesugi, +7 authors, Tamotsu Sugai.
Pathol Int, 2015 May 06; 65(7). PMID: 25940915    Free PMC article.
Management of liver metastases from colorectal cancer.
Yu Katayose, Michiaki Unno.
Clin J Gastroenterol, 2010 Jun 01; 3(3). PMID: 26190118
Synchronous Resectable Metastatic Colorectal Cancer: Lymph Node Involvement Predicts Poor Outcome.
Jianfei Fu, Mengjie Jiang, +5 authors, Ying Yuan.
Medicine (Baltimore), 2015 Jul 30; 94(30). PMID: 26222850    Free PMC article.
Feasibility of the liver-first approach for patients with initially unresectable and not optimally resectable synchronous colorectal liver metastases.
Masayuki Okuno, Etsuro Hatano, +12 authors, Shinji Uemoto.
Surg Today, 2015 Sep 01; 46(6). PMID: 26315324
Factors affecting recurrence and prognosis after R0 resection for colorectal cancer with peritoneal metastasis.
Harunobu Sato, Koutaro Maeda, +2 authors, Hiroshi Takahashi.
J Gastroenterol, 2015 Sep 18; 51(5). PMID: 26377391
Intraoperative Contrast-Enhanced Ultrasound in Colorectal Liver Metastasis Surgery Improves the Identification and Characterization of Nodules.
Julien Hoareau, Aurélien Venara, +4 authors, Christophe Aube.
World J Surg, 2015 Oct 17; 40(1). PMID: 26470698
Colorectal cancer: Metastases to a single organ.
Sina Vatandoust, Timothy J Price, Christos S Karapetis.
World J Gastroenterol, 2015 Nov 12; 21(41). PMID: 26557001    Free PMC article.
Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis.
Chuan-Kai Chou, Chi-Chen Fan, +6 authors, Wei-Chao Chang.
Oncotarget, 2016 Mar 26; 7(18). PMID: 27013588    Free PMC article.
Time-to-Surgery and Survival Outcomes in Resectable Colorectal Liver Metastases: A Multi-Institutional Evaluation.
Julie N Leal, Alexsander K Bressan, +12 authors, William R Jarnagin.
J Am Coll Surg, 2016 Apr 27; 222(5). PMID: 27113514    Free PMC article.
Conversion Chemotherapy for Technically Unresectable Colorectal Liver Metastases: A Retrospective, STROBE-Compliant, Single-Center Study Comparing Chemotherapy Alone and Combination Chemotherapy With Cetuximab or Bevacizumab.
Michele Basso, Vincenzo Dadduzio, +9 authors, Carlo Barone.
Medicine (Baltimore), 2016 May 20; 95(20). PMID: 27196492    Free PMC article.
Radiofrequency ablation vs. hepatic resection for resectable colorectal liver metastases.
Nan He, Qian-Na Jin, +4 authors, Kai-Xiong Tao.
J Huazhong Univ Sci Technolog Med Sci, 2016 Jul 29; 36(4). PMID: 27465325
Multisciplinary management of patients with liver metastasis from colorectal cancer.
Kathleen De Greef, Christian Rolfo, +6 authors, Marc Peeters.
World J Gastroenterol, 2016 Sep 14; 22(32). PMID: 27621569    Free PMC article.
Aggressive surgical resection for concomitant liver and lung metastasis in colorectal cancer.
Sung Hwan Lee, Sung Hyun Kim, +6 authors, Kyung Sik Kim.
Korean J Hepatobiliary Pancreat Surg, 2016 Sep 14; 20(3). PMID: 27621747    Free PMC article.
Mortality-related risk factors and long-term survival after 4460 liver resections in Sweden-a population-based study.
Stefan Gilg, Ernesto Sparrelid, +3 authors, Cecilia Strömberg.
Langenbecks Arch Surg, 2016 Oct 04; 402(1). PMID: 27695941    Free PMC article.
Clinical outcome of node-negative oligometastatic non-small cell lung cancer.
Kiyohiro Sakai, Masayuki Takeda, +7 authors, Kazuhiko Nakagawa.
Thorac Cancer, 2016 Nov 04; 7(6). PMID: 27755813    Free PMC article.
Simultaneous hepatic resection benefits patients with synchronous colorectal cancer liver metastases.
Yuan Li, Xinyu Bi, +6 authors, Jianqiang Cai.
Chin J Cancer Res, 2016 Nov 24; 28(5). PMID: 27877012    Free PMC article.
Yttrium-90 radioembolization for colorectal cancer liver metastases in KRAS wild-type and mutant patients: Clinical and ccfDNA studies.
E Janowski, O Timofeeva, +6 authors, K Unger.
Oncol Rep, 2016 Dec 23; 37(1). PMID: 28004119    Free PMC article.
Stereotactic Body Radiotherapy for Inoperable Liver Tumors: Results of a Single Institutional Experience.
Hussam Hijazi, Marie-Pierre Campeau, +8 authors, Guila Delouya.
Cureus, 2017 Jan 27; 8(12). PMID: 28123916    Free PMC article.
Enhanced colorectal cancer metastases in the alcohol-injured liver.
Ashley M Mohr, John J Gould, +5 authors, Benita L McVicker.
Clin Exp Metastasis, 2017 Feb 09; 34(2). PMID: 28168393
Pre-therapeutic factors for predicting survival after radioembolization: a single-center experience in 389 patients.
K J Paprottka, F Schoeppe, +7 authors, P M Paprottka.
Eur J Nucl Med Mol Imaging, 2017 Feb 16; 44(7). PMID: 28197686
Post-pulmonary metastasectomy prognosis after curative resection for colorectal cancer.
Jee Yeon Kim, In Ja Park, +8 authors, Jin Cheon Kim.
Oncotarget, 2017 Apr 13; 8(22). PMID: 28402263    Free PMC article.
Morphological response contributes to patient selection for rescue liver resection in chemotherapy patients with initially un-resectable colorectal liver metastasis.
Koichi Suzuki, Yuta Muto, +17 authors, Toshiki Rikiyama.
Oncol Lett, 2017 Aug 10; 14(2). PMID: 28789370    Free PMC article.
The role of vitamin D in hepatic metastases from colorectal cancer.
E Shaw, N Massaro, N T Brockton.
Clin Transl Oncol, 2017 Aug 13; 20(3). PMID: 28801869
Trans-arterial chemoperfusion for the treatment of liver metastases of breast cancer and colorectal cancer: Clinical results in palliative care patients.
Tatjana Gruber-Rouh, Marcel Langenbach, +4 authors, Martin Beeres.
World J Clin Oncol, 2017 Aug 30; 8(4). PMID: 28848701    Free PMC article.
Prognostic factors after pulmonary metastasectomy of colorectal cancers: a single-center experience.
Ludovic Fournel, Stefania Maria, +7 authors, Marco Alifano.
J Thorac Dis, 2017 Nov 10; 9(Suppl 12). PMID: 29119012    Free PMC article.
An Overview of the Current Management of Bilobar Colorectal Liver Metastases.
Rebecca K L Griggs, Samir Pathak, Graeme Poston.
Indian J Surg Oncol, 2017 Dec 06; 8(4). PMID: 29203994    Free PMC article.
Stereotactic body radiotherapy for primary and metastatic liver tumors - the Mayo Clinic experience.
Kenneth W Merrell, Jedediah E Johnson, +6 authors, Kenneth R Olivier.
J Radiosurg SBRT, 2016 Jan 01; 4(2). PMID: 29296438    Free PMC article.
Interleukin-1 receptor antagonist inhibits angiogenesis in gastric cancer.
Zhenqiang Gong, Jiachi Ma, +6 authors, Jianbo Du.
Int J Clin Oncol, 2018 Jan 19; 23(4). PMID: 29344744    Free PMC article.
The emerging role of stereotactic radiotherapy in gastrointestinal malignancies: a review of the literature and analysis from the Irish perspective.
Siobhra O'Sullivan, Daniel N Cagney.
Ir J Med Sci, 2018 Feb 10; 187(4). PMID: 29423821
Late gadolinium enhancement of colorectal liver metastases post-chemotherapy is associated with tumour fibrosis and overall survival post-hepatectomy.
Helen M C Cheung, Paul J Karanicolas, +7 authors, Laurent Milot.
Eur Radiol, 2018 Feb 25; 28(8). PMID: 29476216    Free PMC article.
Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after therapy: the NIKOLO trial.
Susen Burock, Severin Daum, +3 authors, Ulrike Stein.
BMC Cancer, 2018 Mar 17; 18(1). PMID: 29544454    Free PMC article.
MicroRNA hsa-let-7e-5p as a potential prognosis marker for rectal carcinoma with liver metastases.
Wenfeng Chen, Guosheng Lin, +10 authors, Yongjian Zhou.
Oncol Lett, 2018 May 08; 15(5). PMID: 29731866    Free PMC article.
Gadofosveset-enhanced magnetic resonance imaging as a problem-solving tool for diagnosing colorectal liver metastases: a case report.
Helen Cheung, Paul Karanicolas, +2 authors, Laurent Milot.
Quant Imaging Med Surg, 2018 May 19; 8(3). PMID: 29774188    Free PMC article.
Surgical outcome of extended liver resections for colorectal liver metastasis compared with standard liver resections.
Go Shinke, Takehiro Noda, +12 authors, Masaki Mori.
Mol Clin Oncol, 2018 Jul 07; 9(1). PMID: 29977546    Free PMC article.
Current role of transarterial chemoembolization and radioembolization in the treatment of metastatic colorectal cancer.
Lourens Bester, Baerbel Meteling, +2 authors, David L Morris.
Hepat Oncol, 2014 Apr 01; 1(2). PMID: 30190956    Free PMC article.
Addition of bevacizumab to preoperative chemotherapy for colorectal liver metastases does not increase perioperative morbidity and mortality.
Alexandros Giakoustidis, Kyriakos Neofytou, Aamir Khan, Satvinder Mudan.
Hepat Oncol, 2014 Oct 01; 1(4). PMID: 30190972    Free PMC article.
Factors Affecting Oncologic Outcomes of 90Y Radioembolization of Heavily Pre-Treated Patients With Colon Cancer Liver Metastases.
Ieva Kurilova, Regina G H Beets-Tan, +10 authors, Constantinos T Sofocleous.
Clin Colorectal Cancer, 2018 Oct 10; 18(1). PMID: 30297264    Free PMC article.
Chemotherapy-induced liver injury in metastatic colorectal cancer: about 48 cases.
Faten Limaiem, Saadia Bouraoui.
Pan Afr Med J, 2018 Nov 21; 30. PMID: 30455827    Free PMC article.
Hepatic resection for primary and secondary liver malignancies.
Stefan Heinrich, Hauke Lang.
Innov Surg Sci, 2017 Mar 24; 2(1). PMID: 31579727    Free PMC article.
Development of novel predictive miRNA/target gene pathways for colorectal cancer distance metastasis to the liver using a bioinformatic approach.
Precious Takondwa Makondi, Po-Li Wei, Chien-Yu Huang, Yu-Jia Chang.
PLoS One, 2019 Feb 27; 14(2). PMID: 30807603    Free PMC article.
Combined resection and radiofrequency ablation for advanced hepatic malignancies: results in 172 patients.
Timothy M Pawlik, Francesco Izzo, +2 authors, Steven A Curley.
Ann Surg Oncol, 2003 Nov 05; 10(9). PMID: 14597445    Free PMC article.
Plasma Exosomal miRNA-139-3p is a Novel Biomarker of Colorectal Cancer.
Wanchao Liu, Dianyu Yang, +6 authors, Dong Li.
J Cancer, 2020 Jul 07; 11(16). PMID: 32626537    Free PMC article.
Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases: Multidisciplinary Consensus Document from the COLLISION Trial Group.
Sanne Nieuwenhuizen, Robbert S Puijk, +49 authors, Martijn R Meijerink.
Cancers (Basel), 2020 Jul 09; 12(7). PMID: 32635230    Free PMC article.
Tumor enhancement of colorectal liver metastases on preoperative gadobutrol-enhanced MRI at 5 minutes post-contrast injection is associated with overall survival post-hepatectomy.
Helen M C Cheung, Paul J Karanicolas, +2 authors, Laurent Milot.
Quant Imaging Med Surg, 2019 Apr 13; 9(2). PMID: 30976555    Free PMC article.
Clinical Outcomes and Predictors in Patients With Unresectable Colorectal Cancer Liver Metastases Following Salvage Percutaneous Radiofrequency Ablation: A Single Center Preliminary Experience.
Ying Wang, Guang-Yuan Zhang, +6 authors, Wen-Tao Li.
Technol Cancer Res Treat, 2020 Oct 10; 19. PMID: 33034276    Free PMC article.
Impact of multidisciplinary tumour boards (MTB) on the clinicopathological characteristics and outcomes of resected colorectal liver metastases across time.
Lionel Chen, Nicholas L Syn, +8 authors, Jin Yao Teo.
World J Surg Oncol, 2020 Sep 05; 18(1). PMID: 32883292    Free PMC article.
Non-alcoholic fatty liver disease and colorectal cancer survival.
Kana Wu, Mike Z Zhai, +4 authors, Bette J Caan.
Cancer Causes Control, 2018 Nov 18; 30(2). PMID: 30443695    Free PMC article.
Cytoreduction for colorectal metastases: liver, lung, peritoneum, lymph nodes, bone, brain. When does it palliate, prolong survival, and potentially cure?
Camille L Stewart, Susanne Warner, +5 authors, Yuman Fong.
Curr Probl Surg, 2018 Dec 12; 55(9). PMID: 30526930    Free PMC article.
A Precision Medicine Drug Discovery Pipeline Identifies Combined CDK2 and 9 Inhibition as a Novel Therapeutic Strategy in Colorectal Cancer.
Jason A Somarelli, Roham Salman Roghani, +10 authors, David S Hsu.
Mol Cancer Ther, 2020 Nov 08; 19(12). PMID: 33158998    Free PMC article.
The Role of Neoadjuvant Chemotherapy in Repeat Local Treatment of Recurrent Colorectal Liver Metastases: A Systematic Review and Meta-Analysis.
Madelon Dijkstra, Sanne Nieuwenhuizen, +9 authors, M Petrousjka van den Tol.
Cancers (Basel), 2021 Feb 10; 13(3). PMID: 33561088    Free PMC article.
Extrahepatic recurrence rates in patients receiving adjuvant hepatic artery infusion and systemic chemotherapy after complete resection of colorectal liver metastases.
Rami M Srouji, Raja R Narayan, +10 authors, Michael I D'Angelica.
J Surg Oncol, 2020 Sep 26; 122(8). PMID: 32976666    Free PMC article.
Patterns and resectability of colorectal cancer recurrences: outcome study within the COLOFOL trial.
P Hansdotter, P Scherman, +5 authors, I Syk.
BJS Open, 2021 Jul 27; 5(4). PMID: 34308474    Free PMC article.
Analysis of factors associated with outcome in patients undergoing isolated hepatic perfusion for unresectable liver metastases from colorectal center.
H Richard Alexander, David L Bartlett, +6 authors, Tatiana H Beresneva.
Ann Surg Oncol, 2009 May 13; 16(7). PMID: 19434456    Free PMC article.
Pulmonary Metastasectomy in Colorectal Cancer: updated analysis of 93 randomized patients - control survival is much better than previously assumed.
M Milosevic, J Edwards, +12 authors, T Treasure.
Colorectal Dis, 2020 May 11; 22(10). PMID: 32388895    Free PMC article.
Primary Tumor Sidedness, RAS and BRAF Mutations and MSI Status as Prognostic Factors in Patients with Colorectal Liver Metastases Treated with Surgery and Thermal Ablation: Results from the Amsterdam Colorectal Liver Met Registry (AmCORE).
Madelon Dijkstra, Sanne Nieuwenhuizen, +10 authors, Martijn R Meijerink.
Biomedicines, 2021 Aug 28; 9(8). PMID: 34440165    Free PMC article.
Repeat Local Treatment of Recurrent Colorectal Liver Metastases, the Role of Neoadjuvant Chemotherapy: An Amsterdam Colorectal Liver Met Registry (AmCORE) Based Study.
Madelon Dijkstra, Sanne Nieuwenhuizen, +10 authors, Monique Petrousjka van den Tol.
Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638481    Free PMC article.
Prognostic factors after ultrasound-guided percutaneous ablation of colorectal liver metastases: A systematic review.
Jeanett Klubien, Andreas P Kohl, +2 authors, Hans-Christian Pommergaard.
Australas J Ultrasound Med, 2018 Apr 02; 21(2). PMID: 34760508    Free PMC article.