Journal Article
. 1995 Nov; 3(5):541-7.
doi: 10.1016/1074-7613(95)90125-6.

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

E A Tivol 1 F Borriello  A N Schweitzer  W P Lynch  J A Bluestone  A H Sharpe  
  • PMID: 7584144
  •     911 citations


The B7-CD28/CTLA-4 costimulatory pathway can provide a signal pivotal for T cell activation. Signaling through this pathway is complex due to the presence of two B7 family members, B7-1 and B7-2, and two counterreceptors, CD28 and CTLA-4. Studies with anti-CTLA-4 monoclonal antibodies have suggested both positive and negative roles for CTLA-4 in T cell activation. To elucidate the in vivo function of CTLA-4, we generated CTLA-4-deficient mice. These mice rapidly develop lymphoproliferative disease with multiorgan lymphocytic infiltration and tissue destruction, with particularly severe myocarditis and pancreatitis, and die by 3-4 weeks of age. The phenotype of the CTLA-4-deficient mouse strain is supported by studies that have suggested a negative role for CTLA-4 in T cell activation. The severe phenotype of mice lacking CTLA-4 implies a critical role for CTLA-4 in down-regulating T cell activation and maintaining immunologic homeostasis. In the absence of CTLA-4, peripheral T cells are activated, can spontaneously proliferate, and may mediate lethal tissue injury.

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Scand J Immunol, 2003 Nov 25; 58(5). PMID: 14629620    Free PMC article.
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.
WanJun Chen, Wenwen Jin, +5 authors, Sharon M Wahl.
J Exp Med, 2003 Dec 17; 198(12). PMID: 14676299    Free PMC article.
Highly Cited.
T lymphocyte dependence of the antibody response to 'T lymphocyte independent type 2' antigens.
A Jeurissen, J L Ceuppens, X Bossuyt.
Immunology, 2003 Dec 18; 111(1). PMID: 14678191    Free PMC article.
TGF-beta: how tolerant can it be?
Sharon M Wahl, Wanjun Chen.
Immunol Res, 2004 Jan 10; 28(3). PMID: 14713712
CTLA-4 and tolerance: the biochemical point of view.
Shunsuke Chikuma, Jeffrey A Bluestone.
Immunol Res, 2004 Jan 10; 28(3). PMID: 14713717
TGF-beta, T-cell tolerance and anti-CD3 therapy.
Ramireddy Bommireddy, Thomas Doetschman.
Trends Mol Med, 2004 Jan 15; 10(1). PMID: 14720578    Free PMC article.
A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses.
Zoltán Fehérvári, Shimon Sakaguchi.
Arthritis Res Ther, 2004 Feb 26; 6(1). PMID: 14979928    Free PMC article.
The role of ICOS and other costimulatory molecules in allergy and asthma.
Anthony J Coyle, Jose-Carlos Gutierrez-Ramos.
Springer Semin Immunopathol, 2004 Mar 05; 25(3-4). PMID: 14999428
The cell surface receptor SLAM controls T cell and macrophage functions.
Ninghai Wang, Abhay Satoskar, +8 authors, Cox Terhorst.
J Exp Med, 2004 May 05; 199(9). PMID: 15123745    Free PMC article.
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes.
Qizhi Tang, Kammi J Henriksen, +7 authors, Jeffrey A Bluestone.
J Exp Med, 2004 Jun 09; 199(11). PMID: 15184499    Free PMC article.
Highly Cited.
Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.
Chloe L Thio, Timothy L Mosbruger, +6 authors, David L Thomas.
J Virol, 2004 Sep 29; 78(20). PMID: 15452244    Free PMC article.
A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity.
Maureen A McGargill, Ben G Wen, Craig M Walsh, Stephen M Hedrick.
Immunity, 2004 Dec 14; 21(6). PMID: 15589167    Free PMC article.
Dendritic cell-mediated T cell polarization.
Esther C de Jong, Hermelijn H Smits, Martien L Kapsenberg.
Springer Semin Immunopathol, 2004 Dec 21; 26(3). PMID: 15609003
Fc receptors and their role in immune regulation and autoimmunity.
Toshiyuki Takai.
J Clin Immunol, 2005 Mar 03; 25(1). PMID: 15742153
Modulating co-stimulation: a rational strategy in the treatment of rheumatoid arthritis?
Vivianne Malmström, Christina Trollmo, Lars Klareskog.
Arthritis Res Ther, 2005 Apr 19; 7 Suppl 2. PMID: 15833144    Free PMC article.
Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease.
Yoshihisa Yamano, Norihiro Takenouchi, +5 authors, Steven Jacobson.
J Clin Invest, 2005 May 03; 115(5). PMID: 15864353    Free PMC article.
Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4.
Tara J Dillon, Kendall D Carey, +2 authors, Philip J S Stork.
Mol Cell Biol, 2005 May 05; 25(10). PMID: 15870282    Free PMC article.
The role of mucosal T lymphocytes in regulating intestinal inflammation.
Holm H Uhlig, Fiona Powrie.
Springer Semin Immunopathol, 2005 Jun 17; 27(2). PMID: 15959782
The B7 family of immune-regulatory ligands.
Mary Collins, Vincent Ling, Beatriz M Carreno.
Genome Biol, 2005 Jun 18; 6(6). PMID: 15960813    Free PMC article.
A peripheral circulating compartment of natural naive CD4 Tregs.
Danila Valmori, Andrea Merlo, +2 authors, Maha Ayyoub.
J Clin Invest, 2005 Jul 12; 115(7). PMID: 16007258    Free PMC article.
Highly Cited.
Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice.
K Inagaki-Ohara, A Sasaki, +7 authors, A Yoshimura.
Gut, 2005 Aug 27; 55(2). PMID: 16120757    Free PMC article.
CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function.
Helga Schneider, Elke Valk, +2 authors, Christopher E Rudd.
Proc Natl Acad Sci U S A, 2005 Aug 30; 102(36). PMID: 16126897    Free PMC article.
Different cell surface oligomeric states of B7-1 and B7-2: implications for signaling.
Sumeena Bhatia, Michael Edidin, Steven C Almo, Stanley G Nathenson.
Proc Natl Acad Sci U S A, 2005 Oct 14; 102(43). PMID: 16221763    Free PMC article.
Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer.
Joseph A Blansfield, Kimberly E Beck, +9 authors, Richard M Sherry.
J Immunother, 2005 Oct 15; 28(6). PMID: 16224277    Free PMC article.
Altered phenotype and function of dendritic cells in children with type 1 diabetes.
F Angelini, E Del Duca, +3 authors, M L Manca Bitti.
Clin Exp Immunol, 2005 Oct 20; 142(2). PMID: 16232222    Free PMC article.
The many sounds of T lymphocyte silence.
Ignacio Melero, Ainhoa Arina, Lieping Chen.
Immunol Res, 2005 Oct 20; 33(2). PMID: 16234580
Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes.
Sharad Purohit, Robert Podolsky, +6 authors, Jin-Xiong She.
J Autoimmune Dis, 2005 Nov 02; 2. PMID: 16259622    Free PMC article.
Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade.
Ajay V Maker, Peter Attia, Steven A Rosenberg.
J Immunol, 2005 Nov 23; 175(11). PMID: 16301685    Free PMC article.
Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation.
Laura T Donlin, Nichole M Danzl, Celestine Wanjalla, Konstantina Alexandropoulos.
Mol Cell Biol, 2005 Nov 30; 25(24). PMID: 16314525    Free PMC article.
CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse.
Su-Yi Tseng, Mengling Liu, Michael L Dustin.
J Immunol, 2005 Dec 13; 175(12). PMID: 16339518    Free PMC article.
Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.
Dirk Homann, Wolfgang Dummer, +4 authors, Matthias G von Herrath.
J Virol, 2005 Dec 15; 80(1). PMID: 16352552    Free PMC article.
Cytotoxic T-lymphocyte antigen-4 inhibits GATA-3 but not T-bet mRNA expression during T helper cell differentiation.
Francesca Nasta, Vanessa Ubaldi, +2 authors, Claudio Pioli.
Immunology, 2006 Feb 16; 117(3). PMID: 16476055    Free PMC article.
Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4.
Kimberly E Beck, Joseph A Blansfield, +12 authors, James C Yang.
J Clin Oncol, 2006 May 20; 24(15). PMID: 16710025    Free PMC article.
Highly Cited.
Checkpoint blockade in cancer immunotherapy.
Alan J Korman, Karl S Peggs, James P Allison.
Adv Immunol, 2006 May 30; 90. PMID: 16730267    Free PMC article.
Highly Cited. Review.
Modification of accessory molecule signaling.
Mary K Crow.
Springer Semin Immunopathol, 2006 Jun 02; 27(4). PMID: 16738953
Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression.
Cecilia Oderup, Lukas Cederbom, +2 authors, Fredrik Ivars.
Immunology, 2006 Jun 15; 118(2). PMID: 16771859    Free PMC article.
Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma.
Ajay V Maker, James C Yang, +11 authors, Steven A Rosenberg.
J Immunother, 2006 Jun 27; 29(4). PMID: 16799341    Free PMC article.
CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.
Luca Gattinoni, Anju Ranganathan, +6 authors, Nicholas P Restifo.
Blood, 2006 Aug 03; 108(12). PMID: 16882704    Free PMC article.
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
Brian T Fife, Matthew D Griffin, +2 authors, Jeffrey A Bluestone.
J Clin Invest, 2006 Aug 04; 116(8). PMID: 16886063    Free PMC article.
Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) immunotherapy for the treatment of prostate cancer.
R Houston Thompson, James P Allison, Eugene D Kwon.
Urol Oncol, 2006 Sep 12; 24(5). PMID: 16962497    Free PMC article.
Genetics of SLE in mice.
Dwight H Kono, Argyrios N Theofilopoulos.
Springer Semin Immunopathol, 2006 Sep 15; 28(2). PMID: 16972052
Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications.
Lequn Li, Vassiliki A Boussiotis.
J Mol Med (Berl), 2006 Sep 15; 84(11). PMID: 16972086
Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.
Simon Read, Rebecca Greenwald, +5 authors, Fiona Powrie.
J Immunol, 2006 Sep 20; 177(7). PMID: 16982872    Free PMC article.
Highly Cited.
CD127+CCR5+CD38+++ CD4+ Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2+ memory CD4+ T cells.
John J Zaunders, Wayne B Dyer, +9 authors, Anthony D Kelleher.
J Virol, 2006 Sep 29; 80(20). PMID: 17005692    Free PMC article.
Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.
John J Zaunders, Susanna Ip, +15 authors, Anthony D Kelleher.
J Virol, 2006 Sep 29; 80(20). PMID: 17005693    Free PMC article.
Modeling CTLA4-linked autoimmunity with RNA interference in mice.
Zhibin Chen, John Stockton, Diane Mathis, Christophe Benoist.
Proc Natl Acad Sci U S A, 2006 Oct 25; 103(44). PMID: 17060611    Free PMC article.
Activating and inhibitory FcgammaRs in autoimmune disorders.
Falk Nimmerjahn.
Springer Semin Immunopathol, 2006 Nov 23; 28(4). PMID: 17115158
Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes.
Dimitrios Tzachanis, Lequn Li, +3 authors, Vassiliki A Boussiotis.
Blood, 2006 Dec 14; 109(7). PMID: 17164348    Free PMC article.
DC-HIL is a negative regulator of T lymphocyte activation.
Jin-Sung Chung, Kota Sato, +2 authors, Kiyoshi Ariizumi.
Blood, 2007 Feb 08; 109(10). PMID: 17284525    Free PMC article.
The CD40, CTLA-4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: back to the future.
Eric M Jacobson, Yaron Tomer.
J Autoimmun, 2007 Mar 21; 28(2-3). PMID: 17369021    Free PMC article.
Immunotherapeutic strategies for high-risk bladder cancer.
Padmanee Sharma, Lloyd J Old, James P Allison.
Semin Oncol, 2007 Mar 27; 34(2). PMID: 17382800    Free PMC article.
Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells.
Monica V Goldberg, Charles H Maris, +12 authors, Charles G Drake.
Blood, 2007 Mar 30; 110(1). PMID: 17392506    Free PMC article.
Differential roles of costimulatory signaling pathways in type 1 diabetes mellitus.
Bernhard O Boehm, Jeffrey A Bluestone.
Rev Diabet Stud, 2007 May 12; 1(4). PMID: 17491700    Free PMC article.
The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling.
Yelina Alvarez, Xiaobin Tang, John E Coligan, Francisco Borrego.
Mol Immunol, 2007 Jun 26; 45(1). PMID: 17588661    Free PMC article.
CTLA-4: From conflict to clinic.
Hema Bashyam.
J Exp Med, 2007 Jul 17; 204(6). PMID: 17632849    Free PMC article.
Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.
Xuguang Tai, Francois Van Laethem, Arlene H Sharpe, Alfred Singer.
Proc Natl Acad Sci U S A, 2007 Aug 19; 104(34). PMID: 17702861    Free PMC article.
Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia.
Frank J Ward, Andrew M Hall, +4 authors, Robert N Barker.
Blood, 2007 Sep 01; 111(2). PMID: 17761830    Free PMC article.
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems.
Joseph F Grosso, Cristin C Kelleher, +10 authors, Charles G Drake.
J Clin Invest, 2007 Oct 13; 117(11). PMID: 17932562    Free PMC article.
Highly Cited.
TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice.
Jos Downey, Andrew Smith, +2 authors, Christopher E Rudd.
Immunol Lett, 2007 Oct 30; 115(1). PMID: 17964663    Free PMC article.
TGFbeta1 and Treg cells: alliance for tolerance.
Ramireddy Bommireddy, Thomas Doetschman.
Trends Mol Med, 2007 Nov 06; 13(11). PMID: 17977791    Free PMC article.
CD200 is induced by ERK and is a potential therapeutic target in melanoma.
Kimberly B Petermann, Gabriela I Rozenberg, +10 authors, Norman E Sharpless.
J Clin Invest, 2007 Nov 17; 117(12). PMID: 18008004    Free PMC article.
Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis.
James C Yang, Marybeth Hughes, +10 authors, Steven A Rosenberg.
J Immunother, 2007 Dec 01; 30(8). PMID: 18049334    Free PMC article.
Highly Cited.
CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization.
Helga Schneider, Xin Smith, +2 authors, Christopher E Rudd.
Eur J Immunol, 2007 Dec 21; 38(1). PMID: 18095376    Free PMC article.
T cell costimulatory molecules in anti-viral immunity: Potential role in immunotherapeutic vaccines.
Tania H Watts, Edward M Bertram, Jacob Bukczynski, Tao Wen.
Can J Infect Dis, 2007 Dec 27; 14(4). PMID: 18159461    Free PMC article.
The heterogeneity of the kinetics of response to ipilimumab in metastatic melanoma: patient cases.
Yvonne M Saenger, Jedd D Wolchok.
Cancer Immun, 2008 Jan 18; 8. PMID: 18198818    Free PMC article.
Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells.
Zhe Shi, Muhaimin Rifa'i, +3 authors, Haruhiko Suzuki.
Immunology, 2008 Jan 22; 124(1). PMID: 18205792    Free PMC article.
CD4 T cells: Balancing the coming and going of autoimmune-mediated inflammation in the CNS.
Bonnie N Dittel.
Brain Behav Immun, 2008 Jan 22; 22(4). PMID: 18207698    Free PMC article.
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients.
F Stephen Hodi, Marcus Butler, +17 authors, Glenn Dranoff.
Proc Natl Acad Sci U S A, 2008 Feb 22; 105(8). PMID: 18287062    Free PMC article.
Highly Cited.
Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation.
Nicolas Perez, Subha Karumuthil-Melethil, +3 authors, Chenthamarakshan Vasu.
J Immunol, 2008 May 06; 180(10). PMID: 18453575    Free PMC article.
CTLA-4 trafficking and surface expression.
Elke Valk, Christopher E Rudd, Helga Schneider.
Trends Immunol, 2008 May 13; 29(6). PMID: 18468488    Free PMC article.
Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunity.
William Stohl, Noam Jacob, +6 authors, Michael N Koss.
J Immunol, 2008 Jun 21; 181(1). PMID: 18566449    Free PMC article.
Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.
Yasushi Onishi, Zoltan Fehervari, Tomoyuki Yamaguchi, Shimon Sakaguchi.
Proc Natl Acad Sci U S A, 2008 Jul 19; 105(29). PMID: 18635688    Free PMC article.
Highly Cited.
Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3.
Yong Zheng, Claire N Manzotti, +4 authors, David M Sansom.
J Immunol, 2008 Jul 22; 181(3). PMID: 18641304    Free PMC article.
Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator.
Yoshihiro Oya, Norihiko Watanabe, +10 authors, Yasushi Saito.
Arthritis Rheum, 2008 Aug 01; 58(8). PMID: 18668554    Free PMC article.
Intracellular concentrations of Ca(2+) modulate the strength of signal and alter the outcomes of cytotoxic T-lymphocyte antigen-4 (CD152)-CD80/CD86 interactions in CD4(+) T lymphocytes.
Asma Ahmed, Sambuddho Mukherjee, Dipankar Nandi.
Immunology, 2008 Aug 20; 126(3). PMID: 18710402    Free PMC article.
Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms.
Amanda Huber, Francesca Menconi, +2 authors, Yaron Tomer.
Endocr Rev, 2008 Sep 09; 29(6). PMID: 18776148    Free PMC article.
Primary biliary cirrhosis is associated with a genetic variant in the 3' flanking region of the CTLA4 gene.
Brian D Juran, Elizabeth J Atkinson, +2 authors, Konstantinos N Lazaridis.
Gastroenterology, 2008 Sep 10; 135(4). PMID: 18778710    Free PMC article.
Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation.
Gisen Kim, Olga Turovskaya, +4 authors, Mitchell Kronenberg.
J Immunol, 2008 Oct 04; 181(8). PMID: 18832683    Free PMC article.
Fas-mediated apoptosis regulates the composition of peripheral alphabeta T cell repertoire by constitutively purging out double negative T cells.
Abdiaziz S Mohamood, Dylan Bargatze, +7 authors, Abdel Rahim A Hamad.
PLoS One, 2008 Oct 23; 3(10). PMID: 18941614    Free PMC article.
CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation.
Asad Bashey, Bridget Medina, +11 authors, Edward D Ball.
Blood, 2008 Nov 01; 113(7). PMID: 18974373    Free PMC article.
Highly Cited.
Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms.
Andrew Berry, Matt Tector, Martin K Oaks.
J Negat Results Biomed, 2008 Nov 19; 7. PMID: 19014504    Free PMC article.
Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease.
Maureen A McGargill, Carmen Choy, Ben G Wen, Stephen M Hedrick.
J Immunol, 2008 Nov 20; 181(11). PMID: 19017948    Free PMC article.
Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.
Keiko Nagahara, Tomohiro Arikawa, +12 authors, Mitsuomi Hirashima.
J Immunol, 2008 Nov 20; 181(11). PMID: 19017954    Free PMC article.
CTLA-4 activation of phosphatidylinositol 3-kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death.
Helga Schneider, Elke Valk, Rufina Leung, Christopher E Rudd.
PLoS One, 2008 Dec 05; 3(12). PMID: 19052636    Free PMC article.
CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.
Josef Kurtz, Forum Raval, +2 authors, Megan Sykes.
Blood, 2009 Jan 31; 113(15). PMID: 19179471    Free PMC article.
B-cell and T-cell epitopes in anti-factor VIII immune responses.
Kathleen P Pratt, Arthur R Thompson.
Clin Rev Allergy Immunol, 2009 Feb 03; 37(2). PMID: 19184559
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.
Randall H Friedline, David S Brown, +7 authors, Cynthia A Chambers.
J Exp Med, 2009 Feb 04; 206(2). PMID: 19188497    Free PMC article.
Highly Cited.
Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.
Johan Verhagen, Leona Gabrysová, +4 authors, David C Wraith.
Proc Natl Acad Sci U S A, 2009 Feb 17; 106(9). PMID: 19218450    Free PMC article.
Innate and adaptive immunity for the pathobiology of Parkinson's disease.
David K Stone, Ashley D Reynolds, R Lee Mosley, Howard E Gendelman.
Antioxid Redox Signal, 2009 Feb 27; 11(9). PMID: 19243239    Free PMC article.
Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade.
Nobuhiro Nakamoto, Hyosun Cho, +8 authors, Kyong-Mi Chang.
PLoS Pathog, 2009 Feb 28; 5(2). PMID: 19247441    Free PMC article.
Highly Cited.
[A novel treatment option in rheumatoid arthritis: abatacept, a selective modulator of T-cell co-stimulation].
Christian Dejaco, Christina Duftner, Edith Wipfler, Michael Schirmer.
Wien Med Wochenschr, 2009 Feb 28; 159(3-4). PMID: 19247593
From tango to quadrilla: current views of the immunological synapse.
Cristina Mazzon, Antonella Viola.
Cell Adh Migr, 2007 Jan 01; 1(1). PMID: 19262090    Free PMC article.
Regulatory T cells overturned: the effectors fight back.
Lucy S K Walker.
Immunology, 2009 Mar 13; 126(4). PMID: 19278420    Free PMC article.
Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?
Leigh R Guerin, Jelmer R Prins, Sarah A Robertson.
Hum Reprod Update, 2009 Mar 13; 15(5). PMID: 19279047    Free PMC article.
Systematic Review.
CTLA-4 co-receptor impacts on the function of Treg and CD8+ T-cell subsets.
Christopher E Rudd.
Eur J Immunol, 2009 Mar 14; 39(3). PMID: 19283722    Free PMC article.
Tumor vaccines for breast cancer.
Karen S Anderson.
Cancer Invest, 2009 Apr 10; 27(4). PMID: 19358018    Free PMC article.
Naturally-existing CD4(+)CD25(+)Foxp3(+) regulatory T cells are required for tolerance to experimental autoimmune thyroiditis induced by either exogenous or endogenous autoantigen.
Gerald P Morris, Nicholas K Brown, Yi-chi M Kong.
J Autoimmun, 2009 Apr 21; 33(1). PMID: 19375891    Free PMC article.
Innate immunity and asthma.
Patricia W Finn, Timothy D Bigby.
Proc Am Thorac Soc, 2009 Apr 24; 6(3). PMID: 19387027    Free PMC article.
Structure-Function analysis of the CTLA-4 interaction with PP2A.
Wendy A Teft, Thu A Chau, Joaquín Madrenas.
BMC Immunol, 2009 May 02; 10. PMID: 19405949    Free PMC article.
CD28 and CTLA-4 coreceptor expression and signal transduction.
Christopher E Rudd, Alison Taylor, Helga Schneider.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426212    Free PMC article.
Highly Cited. Review.
Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells.
Hélène Bour-Jordan, Jeffrey A Bluestone.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426214    Free PMC article.
Costimulatory and coinhibitory receptors in anti-tumor immunity.
Gregory Driessens, Justin Kline, Thomas F Gajewski.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426219    Free PMC article.
OX40 costimulation can abrogate Foxp3+ regulatory T cell-mediated suppression of antitumor immunity.
Naomi Kitamura, Satoshi Murata, +4 authors, Tohru Tani.
Int J Cancer, 2009 May 21; 125(3). PMID: 19455675    Free PMC article.
CTLA4 blockade increases Th17 cells in patients with metastatic melanoma.
Erika von Euw, Thinle Chodon, +4 authors, Antoni Ribas.
J Transl Med, 2009 May 22; 7. PMID: 19457253    Free PMC article.
CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation.
Dorothy K Sojka, Angela Hughson, Deborah J Fowell.
Eur J Immunol, 2009 May 23; 39(6). PMID: 19462377    Free PMC article.
Molecular orchestration of differentiation and function of regulatory T cells.
Li-Fan Lu, Alexander Rudensky.
Genes Dev, 2009 Jun 03; 23(11). PMID: 19487568    Free PMC article.
Molecular and cellular mechanisms of CLL: novel therapeutic approaches.
Lisa Pleyer, Alexander Egle, Tanja Nicole Hartmann, Richard Greil.
Nat Rev Clin Oncol, 2009 Jun 03; 6(7). PMID: 19488076
Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis.
C Coquerelle, G Oldenhove, +6 authors, M Moser.
Gut, 2009 Jun 10; 58(10). PMID: 19505881    Free PMC article.
Anti-CTLA4 Antibody Clinical Trials in Melanoma.
Antoni Ribas.
Update Cancer Ther, 2007 Sep 01; 2(3). PMID: 19543441    Free PMC article.
Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: serious immune related adverse events across a spectrum of cancer subtypes.
Troy Dillard, Chris G Yedinak, Joshi Alumkal, Maria Fleseriu.
Pituitary, 2009 Jul 30; 13(1). PMID: 19639414
Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists.
K S Peggs, S A Quezada, J P Allison.
Clin Exp Immunol, 2009 Aug 08; 157(1). PMID: 19659765    Free PMC article.
The CTLA-4 gene polymorphisms are associated with CTLA-4 protein expression levels in multiple sclerosis patients and with susceptibility to disease.
Lidia Karabon, Agata Kosmaczewska, +8 authors, Irena Frydecka.
Immunology, 2009 Sep 25; 128(1 Suppl). PMID: 19740340    Free PMC article.
How do regulatory T cells work?
A Corthay.
Scand J Immunol, 2009 Sep 16; 70(4). PMID: 19751267    Free PMC article.
Highly Cited. Review.
Biochemical analysis of CTLA-4 immunoreactive material from human blood.
Matt Tector, Bhupendra O Khatri, +2 authors, Martin K Oaks.
BMC Immunol, 2009 Sep 24; 10. PMID: 19772653    Free PMC article.
Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.
Manabu Araki, Denise Chung, +11 authors, Linda S Wicker.
J Immunol, 2009 Sep 29; 183(8). PMID: 19783679    Free PMC article.
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.
Brian T Fife, Kristen E Pauken, +6 authors, Jeffrey A Bluestone.
Nat Immunol, 2009 Sep 29; 10(11). PMID: 19783989    Free PMC article.
Highly Cited.
The role of costimulatory molecules in allergic disease and asthma.
Vincent Lombardi, Abinav K Singh, Omid Akbari.
Int Arch Allergy Immunol, 2009 Sep 30; 151(3). PMID: 19786798    Free PMC article.
CTLA-4 +49A>G polymorphism is associated with the risk but not with the progression of colorectal cancer in Chinese.
Peng Qi, Can-ping Ruan, +6 authors, Chun-fang Gao.
Int J Colorectal Dis, 2009 Sep 30; 25(1). PMID: 19787358
Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis.
Edward J Carr, Heather A Niederer, +4 authors, Kenneth G C Smith.
BMC Med Genet, 2009 Dec 03; 10. PMID: 19951419    Free PMC article.
Mechanisms maintaining peripheral tolerance.
Daniel L Mueller.
Nat Immunol, 2009 Dec 18; 11(1). PMID: 20016506
Highly Cited. Review.
CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.
Wataru Ise, Masako Kohyama, +5 authors, Kenneth M Murphy.
Nat Immunol, 2009 Dec 29; 11(2). PMID: 20037585    Free PMC article.
Gatekeepers of intestinal inflammation.
Heather A Arnett, Joanne L Viney.
Inflamm Res, 2010 Jan 13; 59(1). PMID: 20066780
Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity.
Nitya Jain, Hai Nguyen, Cynthia Chambers, Joonsoo Kang.
Proc Natl Acad Sci U S A, 2010 Jan 19; 107(4). PMID: 20080649    Free PMC article.
Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells.
Alison M Paterson, Arlene H Sharpe.
Nat Immunol, 2010 Jan 20; 11(2). PMID: 20084066    Free PMC article.
Costimulation of Th17 cells: Adding fuel or putting out the fire in the inflamed gut?
Zili Zhang, James T Rosenbaum, +2 authors, David J Hinrichs.
Semin Immunopathol, 2010 Feb 02; 32(1). PMID: 20119686
Evidence for CTLA4 as a susceptibility gene for dilated cardiomyopathy.
Volker Ruppert, Thomas Meyer, +8 authors, German Heart Failure Network.
Eur J Hum Genet, 2010 Feb 11; 18(6). PMID: 20145677    Free PMC article.
Opportunistic autoimmune disorders: from immunotherapy to immune dysregulation.
Yi-chi M Kong, Wei-Zen Wei, Yaron Tomer.
Ann N Y Acad Sci, 2010 Feb 12; 1183. PMID: 20146718    Free PMC article.
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors.
Michael A Curran, Welby Montalvo, Hideo Yagita, James P Allison.
Proc Natl Acad Sci U S A, 2010 Feb 18; 107(9). PMID: 20160101    Free PMC article.
Highly Cited.
Depleting syndecan-4+ T lymphocytes using toxin-bearing dendritic cell-associated heparan sulfate proteoglycan-dependent integrin ligand: a new opportunity for treating activated T cell-driven disease.
Hideo Akiyoshi, Jin-Sung Chung, +2 authors, Kiyoshi Ariizumi.
J Immunol, 2010 Feb 24; 184(7). PMID: 20176742    Free PMC article.
T-cell signaling and immunopathologies.
Christopher E Rudd.
Semin Immunopathol, 2010 Mar 20; 32(2). PMID: 20238116
Small RNA regulators of T cell-mediated autoimmunity.
Lukas T Jeker, Jeffrey A Bluestone.
J Clin Immunol, 2010 Apr 16; 30(3). PMID: 20393792
Genetics of SLE: evidence from mouse models.
Laurence Morel.
Nat Rev Rheumatol, 2010 May 05; 6(6). PMID: 20440287
Inhibitors of B7-CD28 costimulation in urologic malignancies.
R Houston Thompson, Eugene D Kwon, James P Allison.
Immunotherapy, 2009 Jan 01; 1(1). PMID: 20445772    Free PMC article.
In CD28-costimulated human naïve CD4+ T cells, I-κB kinase controls the expression of cell cycle regulatory proteins via interleukin-2-independent mechanisms.
Elisa Lupino, Barbara Buccinnà, +6 authors, Marco Piccinini.
Immunology, 2010 May 15; 131(2). PMID: 20465575    Free PMC article.
The biologic importance of tumor-infiltrating lymphocytes.
F Stephen Hodi, Glenn Dranoff.
J Cutan Pathol, 2010 May 28; 37 Suppl 1. PMID: 20482675    Free PMC article.
Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1 diabetes.
Subha Karumuthil-Melethil, Nicolas Perez, +3 authors, Chenthamarakshan Vasu.
J Immunol, 2010 May 21; 184(12). PMID: 20483724    Free PMC article.
Modulation of CTLA-4 and GITR for cancer immunotherapy.
Francesca Avogadri, Jianda Yuan, +2 authors, Jedd D Wolchok.
Curr Top Microbiol Immunol, 2010 Jun 22; 344. PMID: 20563707    Free PMC article.
Carriage of a tumor necrosis factor polymorphism amplifies the cytotoxic T-lymphocyte antigen 4 attributed risk of primary biliary cirrhosis: evidence for a gene-gene interaction.
Brian D Juran, Elizabeth J Atkinson, +6 authors, Konstantinos N Lazaridis.
Hepatology, 2010 Jun 26; 52(1). PMID: 20578265    Free PMC article.
Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.
Haiyan Ying, Lifen Yang, +5 authors, Jian Zhang.
J Immunol, 2010 Jul 06; 185(3). PMID: 20601598    Free PMC article.
CTLA-4 blockade: therapeutic potential in cancer treatments.
Ahmad A Tarhini, Fatima Iqbal.
Onco Targets Ther, 2010 Jul 10; 3. PMID: 20616954    Free PMC article.
RNA vaccines in cancer treatment.
Anita Bringmann, Stefanie Andrea Erika Held, Annkristin Heine, Peter Brossart.
J Biomed Biotechnol, 2010 Jul 14; 2010. PMID: 20625504    Free PMC article.
Non-hematopoietic expression of IDO is integrally required for inflammatory tumor promotion.
Alexander J Muller, James B DuHadaway, +7 authors, George C Prendergast.
Cancer Immunol Immunother, 2010 Jul 20; 59(11). PMID: 20640572    Free PMC article.
Prostate cancer as a model for tumour immunotherapy.
Charles G Drake.
Nat Rev Immunol, 2010 Jul 24; 10(8). PMID: 20651745    Free PMC article.
Highly Cited. Review.
T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency.
Charis E Teh, Stephen R Daley, Anselm Enders, Christopher C Goodnow.
Proc Natl Acad Sci U S A, 2010 Jul 30; 107(33). PMID: 20668237    Free PMC article.
Immune regulatory antibodies: are they the next advance?
Jedd D Wolchok, Arvin S Yang, Jeffrey S Weber.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693841    Free PMC article.
Modulation of cell signaling networks after CTLA4 blockade in patients with metastatic melanoma.
Begoña Comin-Anduix, Hooman Sazegar, +9 authors, Antoni Ribas.
PLoS One, 2010 Sep 22; 5(9). PMID: 20856802    Free PMC article.
Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy.
Margaret K Callahan, Jedd D Wolchok, James P Allison.
Semin Oncol, 2010 Nov 16; 37(5). PMID: 21074063    Free PMC article.
Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma.
David Berman, Susan M Parker, +5 authors, Hanlin L Wang.
Cancer Immun, 2010 Nov 26; 10. PMID: 21090563    Free PMC article.
Decreased CD4+CD152+ T cell subset and its correlation with the level of antithyroid antibodies in children with chronic autoimmune thyroiditis.
Anna M Kucharska, E Gorska, M Wasik, B Pyrzak.
Eur J Med Res, 2010 Dec 22; 15 Suppl 2. PMID: 21147625    Free PMC article.
Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance.
Virginia A Pedicord, Welby Montalvo, Ingrid M Leiner, James P Allison.
Proc Natl Acad Sci U S A, 2010 Dec 22; 108(1). PMID: 21173239    Free PMC article.
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions.
Nicole Joller, Jason P Hafler, +5 authors, Vijay K Kuchroo.
J Immunol, 2011 Jan 05; 186(3). PMID: 21199897    Free PMC article.
Highly Cited.
Hyponatremia associated with Ipilimumab-induced hypophysitis.
Zachary R Barnard, Brian P Walcott, +2 authors, Jean Valery Coumans.
Med Oncol, 2011 Jan 26; 29(1). PMID: 21264545
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.
Taku Okazaki, Il-mi Okazaki, +9 authors, Tasuku Honjo.
J Exp Med, 2011 Feb 09; 208(2). PMID: 21300912    Free PMC article.
Genetic susceptibility to autoimmune liver disease.
Jochen Mattner.
World J Hepatol, 2011 Feb 11; 3(1). PMID: 21307981    Free PMC article.
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
Li Wang, Rotem Rubinstein, +10 authors, Randolph J Noelle.
J Exp Med, 2011 Mar 09; 208(3). PMID: 21383057    Free PMC article.
Highly Cited.
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Omar S Qureshi, Yong Zheng, +12 authors, David M Sansom.
Science, 2011 Apr 09; 332(6029). PMID: 21474713    Free PMC article.
Highly Cited.
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.
Sergio A Quezada, Karl S Peggs, Tyler R Simpson, James P Allison.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488893    Free PMC article.
Highly Cited. Review.
Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family.
Hélène Bour-Jordan, Jonathan H Esensten, +3 authors, Jeffrey A Bluestone.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488898    Free PMC article.
Highly Cited. Review.
CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans.
Rong Rong Huang, Jason Jalil, +10 authors, Antoni Ribas.
Clin Cancer Res, 2011 May 12; 17(12). PMID: 21558401    Free PMC article.
The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function.
Kay D Gerold, Peilin Zheng, +3 authors, Stephan Kissler.
Diabetes, 2011 May 24; 60(7). PMID: 21602513    Free PMC article.
cDNA sequence and Fab crystal structure of HL4E10, a hamster IgG lambda light chain antibody stimulatory for γδ T cells.
Petra Verdino, Deborah A Witherden, +3 authors, Ian A Wilson.
PLoS One, 2011 Jun 02; 6(5). PMID: 21629689    Free PMC article.
Prostate cancer immunotherapy.
Kenneth F May, James L Gulley, +2 authors, Philip W Kantoff.
Clin Cancer Res, 2011 Jun 28; 17(16). PMID: 21700764    Free PMC article.
Roles of the immune system in skin cancer.
S Rangwala, K Y Tsai.
Br J Dermatol, 2011 Jul 07; 165(5). PMID: 21729024    Free PMC article.
Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens.
Jared H Rowe, James M Ertelt, +2 authors, Sing Sing Way.
Cell Host Microbe, 2011 Jul 20; 10(1). PMID: 21767812    Free PMC article.
Novel immunotherapeutic agents and small molecule antagonists of signalling kinases for the treatment of metastatic melanoma.
Nagendra Natarajan, Sucheta Telang, Donald Miller, Jason Chesney.
Drugs, 2011 Jul 21; 71(10). PMID: 21770473
The past, present, and future of genetic associations in type 1 diabetes.
Peter R Baker, Andrea K Steck.
Curr Diab Rep, 2011 Jul 28; 11(5). PMID: 21792535
T cell costimulation and coinhibition: genetics and disease.
Lisa Scandiuzzi, Kaya Ghosh, Xingxing Zang.
Discov Med, 2011 Sep 01; 12(63). PMID: 21878189    Free PMC article.
Regulatory T cell: a protection for tumour cells.
Yi Wang, Yushui Ma, +4 authors, Xizhong Shen.
J Cell Mol Med, 2011 Sep 08; 16(3). PMID: 21895966    Free PMC article.
Ipilimumab: an anti-CTLA-4 antibody for metastatic melanoma.
Evan J Lipson, Charles G Drake.
Clin Cancer Res, 2011 Sep 09; 17(22). PMID: 21900389    Free PMC article.
Highly Cited. Review.
Association of HLA-B*5801 allele and allopurinol-induced Stevens Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis.
Ratchadaporn Somkrua, Elizabeth E Eickman, +2 authors, Nathorn Chaiyakunapruk.
BMC Med Genet, 2011 Sep 13; 12. PMID: 21906289    Free PMC article.
Systematic Review.
Role of immunotherapy for renal cell cancer in 2011.
Saby George, Roberto Pili, Michael A Carducci, Jenny J Kim.
J Natl Compr Canc Netw, 2011 Sep 16; 9(9). PMID: 21917625    Free PMC article.
Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are associated with lower fractions of memory CD4+ T cells in infants.
Hardis Rabe, Anna-Carin Lundell, +3 authors, Anna Rudin.
J Leukoc Biol, 2011 Sep 22; 90(6). PMID: 21934066    Free PMC article.
CTLA-4: not all costimulation is stimulatory.
Hugh Auchincloss, Laurence A Turka.
J Immunol, 2011 Sep 22; 187(7). PMID: 21934096    Free PMC article.
Beyond cancer vaccines: a reason for future optimism with immunomodulatory therapy.
Michael Postow, Margaret K Callahan, Jedd D Wolchok.
Cancer J, 2011 Sep 29; 17(5). PMID: 21952288    Free PMC article.
Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes.
Xiaojie Wang, Jianqiang Hao, +9 authors, Garth L Warnock.
Diabetes, 2011 Oct 11; 60(12). PMID: 21984581    Free PMC article.
CD4+ T helper 2 cells--microbial triggers, differentiation requirements and effector functions.
Isobel S Okoye, Mark S Wilson.
Immunology, 2011 Nov 03; 134(4). PMID: 22043920    Free PMC article.
Blockade of cytotoxic T-lymphocyte antigen-4 as a new therapeutic approach for advanced melanoma.
Xiang-Yang Wang, Daming Zuo, Devanand Sarkar, Paul B Fisher.
Expert Opin Pharmacother, 2011 Nov 15; 12(17). PMID: 22077831    Free PMC article.
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.
Lucy S K Walker, David M Sansom.
Nat Rev Immunol, 2011 Nov 26; 11(12). PMID: 22116087
Highly Cited.
Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity.
Sue M Liu, Andrew P R Sutherland, +7 authors, Vijay K Kuchroo.
J Immunol, 2011 Nov 30; 188(1). PMID: 22124121    Free PMC article.
Ipilimumab and cancer immunotherapy: a new hope for advanced stage melanoma.
Matthew Mansh.
Yale J Biol Med, 2011 Dec 20; 84(4). PMID: 22180676    Free PMC article.
Safety and efficacy of combination immunotherapy with interferon alfa-2b and tremelimumab in patients with stage IV melanoma.
Ahmad A Tarhini, John Cherian, +5 authors, John M Kirkwood.
J Clin Oncol, 2011 Dec 21; 30(3). PMID: 22184371    Free PMC article.
Cancer immunotherapy comes of age.
Ira Mellman, George Coukos, Glenn Dranoff.
Nature, 2011 Dec 24; 480(7378). PMID: 22193102    Free PMC article.
Highly Cited. Review.
A Study on the Level of T(3), T(4), TSH and the Association of A/G Polymorphism with CTLA-4 Gene in Graves' Hyperthyroidism among South Indian Population.
P Veeramuthumari, W Isabel, K Kannan.
Indian J Clin Biochem, 2012 Jan 03; 26(1). PMID: 22211017    Free PMC article.
Effects of Astragalus polysaccharide on immune responses of porcine PBMC stimulated with PRRSV or CSFV.
Zeng-Yu Zhuge, Yao-Hong Zhu, +5 authors, Jiu-Feng Wang.
PLoS One, 2012 Jan 19; 7(1). PMID: 22253710    Free PMC article.
Constitutive clathrin-mediated endocytosis of CTLA-4 persists during T cell activation.
Omar S Qureshi, Satdip Kaur, +8 authors, David M Sansom.
J Biol Chem, 2012 Jan 21; 287(12). PMID: 22262842    Free PMC article.
Profile of ipilimumab and its role in the treatment of metastatic melanoma.
Sapna P Patel, Scott E Woodman.
Drug Des Devel Ther, 2012 Jan 24; 5. PMID: 22267918    Free PMC article.
The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology.
Julius Clemence R Hafalla, Carla Claser, +4 authors, Eleanor M Riley.
PLoS Pathog, 2012 Feb 10; 8(2). PMID: 22319445    Free PMC article.
Immunotherapy earns its spot in the ranks of cancer therapy.
Drew Pardoll, Charles Drake.
J Exp Med, 2012 Feb 15; 209(2). PMID: 22330682    Free PMC article.
Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cells.
Jozsef Karman, Ji-Lei Jiang, +7 authors, Yunxiang Zhu.
J Biol Chem, 2012 Feb 18; 287(14). PMID: 22337882    Free PMC article.
T cell costimulatory and coinhibitory pathways in vascular inflammatory diseases.
Andrew H Lichtman.
Front Physiol, 2012 Feb 23; 3. PMID: 22355289    Free PMC article.
Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.
Xuguang Tai, François Van Laethem, +9 authors, Alfred Singer.
Blood, 2012 Mar 10; 119(22). PMID: 22403258    Free PMC article.
Highly Cited.
The blockade of immune checkpoints in cancer immunotherapy.
Drew M Pardoll.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437870    Free PMC article.
Highly Cited. Review.
Targeting immune checkpoints: releasing the restraints on anti-tumor immunity for patients with melanoma.
Michael A Postow, James Harding, Jedd D Wolchok.
Cancer J, 2012 Mar 29; 18(2). PMID: 22453017    Free PMC article.
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape.
Janis M Taube, Robert A Anders, +8 authors, Lieping Chen.
Sci Transl Med, 2012 Mar 31; 4(127). PMID: 22461641    Free PMC article.
Highly Cited.
Suppression of antigen-specific T cell responses by the Kaposi's sarcoma-associated herpesvirus viral OX2 protein and its cellular orthologue, CD200.
Karen Misstear, Simon A Chanas, +7 authors, David J Blackbourn.
J Virol, 2012 Apr 12; 86(11). PMID: 22491458    Free PMC article.
Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.
Stefano Caserta, Norman Nausch, +5 authors, Rose Zamoyska.
PLoS One, 2012 Apr 13; 7(4). PMID: 22496920    Free PMC article.
Therapeutic antibodies against cancer.
Mark J Adler, Dimiter S Dimitrov.
Hematol Oncol Clin North Am, 2012 Apr 24; 26(3). PMID: 22520975    Free PMC article.
Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection.
Lucile Garidou, Sara Heydari, Selamawit Gossa, Dorian B McGavern.
J Virol, 2012 May 04; 86(13). PMID: 22553324    Free PMC article.
The role of coinhibitory signaling pathways in transplantation and tolerance.
Martina M McGrath, Nader Najafian.
Front Immunol, 2012 May 09; 3. PMID: 22566929    Free PMC article.
Melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities.
Florencia Paula Madorsky-Rowdo, María Laura Lacreu, José Mordoh.
Front Immunol, 2012 May 09; 3. PMID: 22566975    Free PMC article.
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
Tadashi Yokosuka, Masako Takamatsu, +3 authors, Takashi Saito.
J Exp Med, 2012 May 30; 209(6). PMID: 22641383    Free PMC article.
Highly Cited.
Immunogenetic mechanisms leading to thyroid autoimmunity: recent advances in identifying susceptibility genes and regions.
Oliver J Brand, Stephen C L Gough.
Curr Genomics, 2012 Jun 02; 12(8). PMID: 22654554    Free PMC article.
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.
Julie R Brahmer, Scott S Tykodi, +23 authors, Jon M Wigginton.
N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658128    Free PMC article.
Highly Cited.
T-cell tolerance: central and peripheral.
Yan Xing, Kristin A Hogquist.
Cold Spring Harb Perspect Biol, 2012 Jun 05; 4(6). PMID: 22661634    Free PMC article.
Highly Cited.
CTLA-4 exon 1 +49A/G polymorphism is associated with renal involvement in pediatric Henoch-Schönlein purpura.
Jian-Jun Wang, Yan-Ping Shi, +2 authors, Li-Ping Zou.
Pediatr Nephrol, 2012 Jun 16; 27(11). PMID: 22700162
Targeting regulatory T cells in the treatment of type 1 diabetes mellitus.
S M Cabrera, M R Rigby, R G Mirmira.
Curr Mol Med, 2012 Jun 20; 12(10). PMID: 22709273    Free PMC article.
CD28 family and chronic rejection: "to belatacept...And beyond!".
Marcos V Silva, Juliana R Machado, +3 authors, Rosana R M Corrêa.
J Transplant, 2012 Jun 22; 2012. PMID: 22720132    Free PMC article.
Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell.
James E D Thaventhiran, Anja Hoffmann, +4 authors, Douglas T Fearon.
Proc Natl Acad Sci U S A, 2012 Jun 30; 109(33). PMID: 22745171    Free PMC article.
Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.
Chun Jing Wang, Rupert Kenefeck, +6 authors, Lucy S K Walker.
J Immunol, 2012 Jul 04; 189(3). PMID: 22753931    Free PMC article.
Synthesized OVA323-339MAP octamers mitigate OVA-induced airway inflammation by regulating Foxp3 T regulatory cells.
Wen Su, Wenwei Zhong, Yanjie Zhang, Zhenwei Xia.
BMC Immunol, 2012 Jul 10; 13. PMID: 22769043    Free PMC article.
Novel anti-melanoma immunotherapies: disarming tumor escape mechanisms.
Sivan Sapoznik, Ohad Hammer, +4 authors, Gal Markel.
Clin Dev Immunol, 2012 Jul 11; 2012. PMID: 22778766    Free PMC article.
Modeling and predicting clinical efficacy for drugs targeting the tumor milieu.
Mallika Singh, Napoleone Ferrara.
Nat Biotechnol, 2012 Jul 12; 30(7). PMID: 22781694
Metabolic regulation of organelle homeostasis in lupus T cells.
Tiffany N Caza, Gergely Talaber, Andras Perl.
Clin Immunol, 2012 Jul 28; 144(3). PMID: 22836085    Free PMC article.
Autologous regulatory T cells for the treatment of type 1 diabetes.
James A Thompson, Daniel Perry, Todd M Brusko.
Curr Diab Rep, 2012 Jul 31; 12(5). PMID: 22843491
Immunotherapy for prostate cancer enters its golden age.
Sosipatros A Boikos, Emmanuel S Antonarakis.
Clin Med Insights Oncol, 2012 Jul 31; 6. PMID: 22844202    Free PMC article.
Role of the PD-1 pathway in the immune response.
L V Riella, A M Paterson, A H Sharpe, A Chandraker.
Am J Transplant, 2012 Aug 21; 12(10). PMID: 22900886    Free PMC article.
Highly Cited. Review.
Influence of human immune cells on cancer: studies at the University of Colorado.
Tullia C Bruno, Jena D French, +7 authors, Jill E Slansky.
Immunol Res, 2012 Sep 04; 55(1-3). PMID: 22941561    Free PMC article.
Impaired proteasome function activates GATA3 in T cells and upregulates CTLA-4: relevance for Sézary syndrome.
Heather M Gibson, Anjali Mishra, +3 authors, Henry K Wong.
J Invest Dermatol, 2012 Sep 07; 133(1). PMID: 22951729    Free PMC article.
Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis.
Amy Dhirapong, Guo-Xiang Yang, +9 authors, M Eric Gershwin.
Hepatology, 2012 Sep 22; 57(2). PMID: 22996325    Free PMC article.
Coinhibitory molecules in autoimmune diseases.
Norihiko Watanabe, Hiroshi Nakajima.
Clin Dev Immunol, 2012 Sep 22; 2012. PMID: 22997525    Free PMC article.
T-cell inhibitors: a bench-to-bedside review.
Shinjita Das, Kiyoshi Ariizumi, Ponciano D Cruz.
Dermatitis, 2012 Sep 27; 23(5). PMID: 23010825    Free PMC article.
Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal.
Yuning Lu, Helga Schneider, Christopher E Rudd.
Blood, 2012 Oct 11; 120(23). PMID: 23047820    Free PMC article.
Strategies for enhancing vaccine-induced CTL antitumor immune responses.
Xin Yong, Yü-Feng Xiao, +5 authors, Shi-Ming Yang.
J Biomed Biotechnol, 2012 Oct 25; 2012. PMID: 23093850    Free PMC article.
Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.
Herbert G Kasler, Hyung W Lim, +3 authors, Eric Verdin.
EMBO J, 2012 Oct 30; 31(23). PMID: 23103766    Free PMC article.
CTLA-4-Tg/CD-28-KO Mice Exhibit Reduced T Cell Proliferation in vivo Compared to CD-28-KO Mice in a Graft-versus-host Disease Model.
Jong-Sun Yoo, Yun-Jung Lee, +2 authors, Kwang Woo Hwang.
Korean J Physiol Pharmacol, 2012 Nov 03; 16(5). PMID: 23118560    Free PMC article.
Immunology beats cancer: a blueprint for successful translation.
Drew M Pardoll.
Nat Immunol, 2012 Nov 20; 13(12). PMID: 23160205    Free PMC article.
Polymorphisms in genes encoding nonsarcomeric proteins and their role in the pathogenesis of dilated cardiomyopathy.
J Staab, V Ruppert, S Pankuweit, T Meyer.
Herz, 2012 Nov 29; 37(8). PMID: 23188159
Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice.
Kunihiro Ichinose, Zheng Zhang, +6 authors, George C Tsokos.
Arthritis Rheum, 2012 Dec 04; 65(3). PMID: 23203389    Free PMC article.
The role of B7 family molecules in hematologic malignancy.
Paul Greaves, John G Gribben.
Blood, 2012 Dec 12; 121(5). PMID: 23223433    Free PMC article.
Association of the CTLA-4 +49A/G polymorphism with rheumatoid arthritis in Chinese Han population.
Ming-Jie Tang, Zu-Bin Zhou.
Mol Biol Rep, 2012 Dec 25; 40(3). PMID: 23264071
CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.
Johan Verhagen, Raphaël Genolet, +5 authors, David C Wraith.
Proc Natl Acad Sci U S A, 2012 Dec 26; 110(3). PMID: 23267099    Free PMC article.
Experimental advances in understanding allergic airway inflammation.
Christine M Deppong, Jonathan M Green.
Front Biosci (Schol Ed), 2013 Jan 02; 5(1). PMID: 23277043    Free PMC article.
The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes.
Melanie Stumpf, Xuyu Zhou, Jeffrey A Bluestone.
J Immunol, 2013 Jan 08; 190(3). PMID: 23293354    Free PMC article.
Advances in targeting cell surface signalling molecules for immune modulation.
Sheng Yao, Yuwen Zhu, Lieping Chen.
Nat Rev Drug Discov, 2013 Feb 02; 12(2). PMID: 23370250    Free PMC article.
Highly Cited. Review.
Recipient cytotoxic T lymphocyte antigen 4 +49 single-nucleotide polymorphism is not associated with acute rejection after liver transplantation in Chinese population.
Zhijun Jiang, Ying Chen, +3 authors, Shusen Zheng.
Int J Med Sci, 2013 Feb 02; 10(3). PMID: 23372431    Free PMC article.
CTLA-4 blockade in tumor models: an overview of preclinical and translational research.
Joseph F Grosso, Maria N Jure-Kunkel.
Cancer Immun, 2013 Feb 08; 13. PMID: 23390376    Free PMC article.
Highly Cited. Review.
Rationale for targeting the immune system through checkpoint molecule blockade in the treatment of non-small-cell lung cancer.
C Zielinski, S Knapp, C Mascaux, F Hirsch.
Ann Oncol, 2013 Feb 09; 24(5). PMID: 23393121    Free PMC article.
Impact of microbes on autoimmune diseases.
Claudia Danzer, Jochen Mattner.
Arch Immunol Ther Exp (Warsz), 2013 Feb 19; 61(3). PMID: 23417246    Free PMC article.
Immunomodulatory therapy for melanoma: ipilimumab and beyond.
Margaret K Callahan, Michael A Postow, Jedd D Wolchok.
Clin Dermatol, 2013 Feb 27; 31(2). PMID: 23438382    Free PMC article.
The nature of activatory and tolerogenic dendritic cell-derived signal II.
Ghaith Bakdash, Simone P Sittig, +2 authors, I Jolanda M de Vries.
Front Immunol, 2013 Mar 02; 4. PMID: 23450201    Free PMC article.
Type 1 diabetes: translating mechanistic observations into effective clinical outcomes.
Kevan C Herold, Dario A A Vignali, Anne Cooke, Jeffrey A Bluestone.
Nat Rev Immunol, 2013 Mar 26; 13(4). PMID: 23524461    Free PMC article.
Highly Cited. Review.
Potential regulatory role of in vitro-expanded Vδ1 T cells from human peripheral blood.
Fang Hua, Ning Kang, +3 authors, Wei He.
Immunol Res, 2013 Mar 28; 56(1). PMID: 23532670
Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer.
Satoshi Wada, Christopher M Jackson, +10 authors, Charles G Drake.
J Transl Med, 2013 Apr 06; 11. PMID: 23557194    Free PMC article.
The role of vitamin d in primary biliary cirrhosis: possible genetic and cell signaling mechanisms.
Khanh Vinh Quốc L Ng, Lan Thi Hoàng Nguyễn.
Gastroenterol Res Pract, 2013 Apr 17; 2013. PMID: 23589715    Free PMC article.
At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy.
Andrew M Intlekofer, Craig B Thompson.
J Leukoc Biol, 2013 Apr 30; 94(1). PMID: 23625198    Free PMC article.
Highly Cited. Review.
Optimal management of metastatic melanoma: current strategies and future directions.
Marta Batus, Salman Waheed, +3 authors, Howard L Kaufman.
Am J Clin Dermatol, 2013 May 17; 14(3). PMID: 23677693    Free PMC article.
Novel antibodies targeting immune regulatory checkpoints for cancer therapy.
Chern Siang Lee, Mark Cragg, Martin Glennie, Peter Johnson.
Br J Clin Pharmacol, 2013 May 25; 76(2). PMID: 23701301    Free PMC article.
A bispecific protein capable of engaging CTLA-4 and MHCII protects non-obese diabetic mice from autoimmune diabetes.
Hongmei Zhao, Jozsef Karman, +8 authors, Yunxiang Zhu.
PLoS One, 2013 May 25; 8(5). PMID: 23704916    Free PMC article.
Regulatory cells and transplantation tolerance.
Stephen P Cobbold, Herman Waldmann.
Cold Spring Harb Perspect Med, 2013 Jun 05; 3(6). PMID: 23732858    Free PMC article.
B7-1/B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3+ regulatory T cells.
James M Ertelt, Esra Z Buyukbasaran, +3 authors, Sing Sing Way.
J Leukoc Biol, 2013 Jun 08; 94(2). PMID: 23744647    Free PMC article.
Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma.
Jedd D Wolchok, F Stephen Hodi, +9 authors, Alan J Korman.
Ann N Y Acad Sci, 2013 Jun 19; 1291. PMID: 23772560    Free PMC article.
Highly Cited. Review.
Molecular insights for optimizing T cell receptor specificity against cancer.
Michael Hebeisen, Susanne G Oberle, +3 authors, Nathalie Rufer.
Front Immunol, 2013 Jun 27; 4. PMID: 23801991    Free PMC article.
The heart of the matter: protection of the myocardium from T cells.
Andrew H Lichtman.
J Autoimmun, 2013 Jul 03; 45. PMID: 23810579    Free PMC article.
Treg and CTLA-4: two intertwining pathways to immune tolerance.
Lucy S K Walker.
J Autoimmun, 2013 Jul 16; 45. PMID: 23849743    Free PMC article.
Highly Cited. Review.
Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.
Christopher J Nirschl, Charles G Drake.
Clin Cancer Res, 2013 Jul 23; 19(18). PMID: 23868869    Free PMC article.
Highly Cited. Review.
Synergy between chemotherapeutic agents and CTLA-4 blockade in preclinical tumor models.
Maria Jure-Kunkel, Gregg Masters, +4 authors, Rachel Humphrey.
Cancer Immunol Immunother, 2013 Jul 23; 62(9). PMID: 23873089    Free PMC article.
Home sweet home: the tumor microenvironment as a haven for regulatory T cells.
Beatrice Ondondo, Emma Jones, Andrew Godkin, Awen Gallimore.
Front Immunol, 2013 Jul 23; 4. PMID: 23874342    Free PMC article.
Role of CTLA4 in the proliferation and survival of chronic lymphocytic leukemia.
Amit K Mittal, Nagendra K Chaturvedi, +5 authors, Shantaram S Joshi.
PLoS One, 2013 Aug 13; 8(8). PMID: 23936412    Free PMC article.
The great balancing act: regulation and fate of antiviral T-cell interactions.
E Ashley Moseman, Dorian B McGavern.
Immunol Rev, 2013 Aug 21; 255(1). PMID: 23947351    Free PMC article.
Fcγ receptors enable anticancer action of proapoptotic and immune-modulatory antibodies.
Jeong M Kim, Avi Ashkenazi.
J Exp Med, 2013 Aug 28; 210(9). PMID: 23980122    Free PMC article.
Analysis of cytotoxic T-lymphocyte-associated antigen-4 and MMP-9 genes' methylation and their expression profiles with risk of non-alcoholic fatty liver disease.
Dor Mohammad Kordi Tamandani, Mohammad Hashemi, Sara Shafiepour.
Indian J Hum Genet, 2013 Sep 11; 19(2). PMID: 24019613    Free PMC article.
Differential CTLA-4 expression in human CD4+ versus CD8+ T cells is associated with increased NFAT1 and inhibition of CD4+ proliferation.
D V Chan, H M Gibson, +4 authors, H K Wong.
Genes Immun, 2013 Nov 01; 15(1). PMID: 24173147    Free PMC article.
B cells are critical for autoimmune pathology in Scurfy mice.
Susanne Aschermann, Christian H K Lehmann, +3 authors, Falk Nimmerjahn.
Proc Natl Acad Sci U S A, 2013 Nov 07; 110(47). PMID: 24194550    Free PMC article.
Recent advances in immunotherapy for non-small-cell lung cancer.
Hiroyuki Suzuki, Yuki Owada, +13 authors, Mitsukazu Gotoh.
Hum Vaccin Immunother, 2013 Nov 08; 10(2). PMID: 24196313    Free PMC article.
Anti-cytotoxic T lymphocyte antigen-4 antibodies in melanoma.
Giulio Tosti, Emilia Cocorocchio, Elisabetta Pennacchioli.
Clin Cosmet Investig Dermatol, 2013 Nov 10; 6. PMID: 24204168    Free PMC article.
Re-adapting T cells for cancer therapy: from mouse models to clinical trials.
Ingunn M Stromnes, Thomas M Schmitt, +2 authors, Philip D Greenberg.
Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329795    Free PMC article.
PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses.
Victor D Fedorov, Maria Themeli, Michel Sadelain.
Sci Transl Med, 2013 Dec 18; 5(215). PMID: 24337479    Free PMC article.
Highly Cited.
Clinical Implications of Co-Inhibitory Molecule Expression in the Tumor Microenvironment for DC Vaccination: A Game of Stop and Go.
Angela Vasaturo, Stefania Di Blasio, +4 authors, Stanleyson V Hato.
Front Immunol, 2013 Dec 19; 4. PMID: 24348481    Free PMC article.
[Progress in immunotherapy for non-small cell lung cancer].
Yan Xu, Mengzhao Wang.
Zhongguo Fei Ai Za Zhi, 2014 Jan 09; 17(1). PMID: 24398312    Free PMC article.
PD-1 as a potential target in cancer therapy.
David F McDermott, Michael B Atkins.
Cancer Med, 2014 Jan 10; 2(5). PMID: 24403232    Free PMC article.
Highly Cited. Review.
IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells.
Kesley Attridge, Rupert Kenefeck, +5 authors, Lucy S K Walker.
J Immunol, 2014 Jan 29; 192(5). PMID: 24470500    Free PMC article.
Neoadjuvant treatment of melanoma: case reports and review.
Shachar Laks, Kevin A Brueske, Eddy C Hsueh.
Exp Hematol Oncol, 2014 Feb 07; 2(1). PMID: 24499550    Free PMC article.
Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression.
Matthew C Banton, Kerry L Inder, +2 authors, Helga Schneider.
Mol Cell Biol, 2014 Feb 12; 34(8). PMID: 24515439    Free PMC article.
Immune checkpoint blockade: the hope for immunotherapy as a treatment of lung cancer?
Julie R Brahmer.
Semin Oncol, 2014 Feb 26; 41(1). PMID: 24565586    Free PMC article.
Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an "innocent bystander".
Lucia Gelao, Carmen Criscitiello, +2 authors, Giuseppe Curigliano.
Toxins (Basel), 2014 Mar 07; 6(3). PMID: 24594636    Free PMC article.
Armed therapeutic viruses - a disruptive therapy on the horizon of cancer immunotherapy.
Maxine Bauzon, Terry Hermiston.
Front Immunol, 2014 Mar 08; 5. PMID: 24605114    Free PMC article.
The soluble form of CTLA-4 from serum of patients with autoimmune diseases regulates T-cell responses.
Rita Simone, Giampaola Pesce, +4 authors, Daniele Saverino.
Biomed Res Int, 2014 Mar 08; 2014. PMID: 24605322    Free PMC article.
Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function.
Melanie Stumpf, Xuyu Zhou, Shunsuke Chikuma, Jeffrey A Bluestone.
Eur J Immunol, 2014 Mar 22; 44(6). PMID: 24648182    Free PMC article.
Protein kinase C-η controls CTLA-4-mediated regulatory T cell function.
Kok-Fai Kong, Guo Fu, +10 authors, Amnon Altman.
Nat Immunol, 2014 Apr 08; 15(5). PMID: 24705298    Free PMC article.
Highly Cited.
Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs.
Kesley Attridge, Lucy S K Walker.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712457    Free PMC article.
FOXP3 and scurfy: how it all began.
Fred Ramsdell, Steven F Ziegler.
Nat Rev Immunol, 2014 Apr 12; 14(5). PMID: 24722479
Highly Cited. Review.
Immunotherapy: it takes a village.
Drew Pardoll.
Science, 2014 Apr 12; 344(6180). PMID: 24723594    Free PMC article.
BRAF and beyond: Tailoring strategies for the individual melanoma patient.
Anthony Jarkowski, Nikhil I Khushalani.
J Carcinog, 2014 Apr 17; 13. PMID: 24737949    Free PMC article.
Unmet needs in squamous cell carcinoma of the lung: potential role for immunotherapy.
Thomas E Stinchcombe.
Med Oncol, 2014 Apr 22; 31(5). PMID: 24748366    Free PMC article.
Evolving strategies for cancer and autoimmunity: back to the future.
Peter J L Lane, Fiona M McConnell, +3 authors, David R Withers.
Front Immunol, 2014 May 02; 5. PMID: 24782861    Free PMC article.
Paradigm Shift in Dendritic Cell-Based Immunotherapy: From in vitro Generated Monocyte-Derived DCs to Naturally Circulating DC Subsets.
Florian Wimmers, Gerty Schreibelt, +2 authors, I Jolanda M De Vries.
Front Immunol, 2014 May 02; 5. PMID: 24782868    Free PMC article.
A novel pancreatic β-cell targeting bispecific-antibody (BsAb) can prevent the development of type 1 diabetes in NOD mice.
Palash Bhattacharya, Jilao Fan, +5 authors, Bellur S Prabhakar.
Clin Immunol, 2014 May 06; 153(1). PMID: 24792135    Free PMC article.
Primer on tumor immunology and cancer immunotherapy.
Timothy J Harris, Charles G Drake.
J Immunother Cancer, 2013 Jan 01; 1. PMID: 24829749    Free PMC article.
Tumor immunology and cancer immunotherapy: summary of the 2013 SITC primer.
Raju R Raval, Andrew B Sharabi, +2 authors, Padmanee Sharma.
J Immunother Cancer, 2014 Jun 03; 2. PMID: 24883190    Free PMC article.
CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells.
Andreas Herrmann, Saul J Priceman, +10 authors, Hua Yu.
J Clin Invest, 2014 Jun 04; 124(7). PMID: 24892807    Free PMC article.
Opportunistic Autoimmune Disorders Potentiated by Immune-Checkpoint Inhibitors Anti-CTLA-4 and Anti-PD-1.
Yi-Chi M Kong, Jeffrey C Flynn.
Front Immunol, 2014 Jun 07; 5. PMID: 24904570    Free PMC article.
Clinical Benefit from Ipilimumab Therapy in Melanoma Patients may be Associated with Serum CTLA4 Levels.
Anna M Leung, Agnes Fermin Lee, +8 authors, Delphine J Lee.
Front Oncol, 2014 Jun 07; 4. PMID: 24904825    Free PMC article.
Genetically modified T-cell therapy for osteosarcoma.
Christopher DeRenzo, Stephen Gottschalk.
Adv Exp Med Biol, 2014 Jun 14; 804. PMID: 24924183    Free PMC article.
Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles.
Laura Esposito, Kara M D Hunter, +12 authors, Linda S Wicker.
J Immunol, 2014 Jun 15; 193(2). PMID: 24928993    Free PMC article.
DC-HIL+ CD14+ HLA-DR no/low cells are a potential blood marker and therapeutic target for melanoma.
Jake Turrentine, Jin-Sung Chung, +7 authors, Ponciano D Cruz.
J Invest Dermatol, 2014 Jun 17; 134(11). PMID: 24933321    Free PMC article.
Humanized mice as a model for aberrant responses in human T cell immunotherapy.
Nalini K Vudattu, Frank Waldron-Lynch, +6 authors, Kevan C Herold.
J Immunol, 2014 Jun 20; 193(2). PMID: 24943216    Free PMC article.
TREG-cell therapies for autoimmune rheumatic diseases.
Makoto Miyara, Yoshinaga Ito, Shimon Sakaguchi.
Nat Rev Rheumatol, 2014 Jul 02; 10(9). PMID: 24980140
Highly Cited. Review.
PD-1 as an emerging therapeutic target in renal cell carcinoma: current evidence.
Scott S Tykodi.
Onco Targets Ther, 2014 Aug 13; 7. PMID: 25114573    Free PMC article.
Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.
Monica W Buckley, Sanja Arandjelovic, +3 authors, Kodi S Ravichandran.
PLoS One, 2014 Aug 26; 9(8). PMID: 25153088    Free PMC article.
CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy.
Christine E Engeland, Christian Grossardt, +10 authors, Guy Ungerechts.
Mol Ther, 2014 Aug 27; 22(11). PMID: 25156126    Free PMC article.
Highly Cited.
CD160 isoforms and regulation of CD4 and CD8 T-cell responses.
Mohamed El-Far, Charles Pellerin, +8 authors, George Kukolj.
J Transl Med, 2014 Sep 03; 12. PMID: 25179432    Free PMC article.
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.
Hye Sun Kuehn, Weiming Ouyang, +33 authors, Gulbu Uzel.
Science, 2014 Sep 13; 345(6204). PMID: 25213377    Free PMC article.
Highly Cited.
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Li Wang, Isabelle Le Mercier, +7 authors, Randolph J Noelle.
Proc Natl Acad Sci U S A, 2014 Oct 01; 111(41). PMID: 25267631    Free PMC article.
T cell-macrophage interactions and granuloma formation in vasculitis.
Marc Hilhorst, Tsuyoshi Shirai, +2 authors, Cornelia M Weyand.
Front Immunol, 2014 Oct 14; 5. PMID: 25309534    Free PMC article.
Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.
Desirée Schubert, Claudia Bode, +37 authors, Bodo Grimbacher.
Nat Med, 2014 Oct 21; 20(12). PMID: 25329329    Free PMC article.
Highly Cited.
Neuropilin-1 expression is induced on tolerant self-reactive CD8+ T cells but is dispensable for the tolerant phenotype.
Stephanie R Jackson, Melissa Berrien-Elliott, +2 authors, Ryan M Teague.
PLoS One, 2014 Oct 25; 9(10). PMID: 25343644    Free PMC article.
Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4.
Sebastian Zeissig, Britt-Sabina Petersen, +11 authors, Richard S Blumberg.
Gut, 2014 Nov 05; 64(12). PMID: 25367873    Free PMC article.
Antigen-induced regulation of T-cell motility, interaction with antigen-presenting cells and activation through endogenous thrombospondin-1 and its receptors.
Sten-Erik Bergström, Mehmet Uzunel, +2 authors, Karl-Gösta Sundqvist.
Immunology, 2014 Nov 14; 144(4). PMID: 25393517    Free PMC article.
Double negative (DN) αβ T cells: misperception and overdue recognition.
Maria N Martina, Sanjeev Noel, +2 authors, Abdel Rahim A Hamad.
Immunol Cell Biol, 2014 Nov 26; 93(3). PMID: 25420721    Free PMC article.
To affinity and beyond: harnessing the T cell receptor for cancer immunotherapy.
Jessica E Thaxton, Zihai Li.
Hum Vaccin Immunother, 2014 Dec 09; 10(11). PMID: 25483644    Free PMC article.
Novel immunotherapies for hematologic malignancies.
Michelle H Nelson, Chrystal M Paulos.
Immunol Rev, 2014 Dec 17; 263(1). PMID: 25510273    Free PMC article.
Checkpoint blockade immunotherapy relies on T-bet but not Eomes to induce effector function in tumor-infiltrating CD8+ T cells.
Melissa M Berrien-Elliott, Jinyun Yuan, +4 authors, Ryan M Teague.
Cancer Immunol Res, 2014 Dec 18; 3(2). PMID: 25516478    Free PMC article.
Balance and imbalance in the immune system: life on the edge.
Suzanne L Topalian, Arlene H Sharpe.
Immunity, 2014 Dec 18; 41(5). PMID: 25517610    Free PMC article.
The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.
Peter T Sage, Alison M Paterson, Scott B Lovitch, Arlene H Sharpe.
Immunity, 2014 Dec 20; 41(6). PMID: 25526313    Free PMC article.
Highly Cited.
Clinical blockade of PD1 and LAG3--potential mechanisms of action.
Linh T Nguyen, Pamela S Ohashi.
Nat Rev Immunol, 2014 Dec 24; 15(1). PMID: 25534622
Highly Cited. Review.
Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.
Helga Schneider, Christopher E Rudd.
Front Immunol, 2014 Dec 30; 5. PMID: 25538704    Free PMC article.
Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivo.
Rituparna Das, Rakesh Verma, +8 authors, Kavita M Dhodapkar.
J Immunol, 2014 Dec 30; 194(3). PMID: 25539810    Free PMC article.
Highly Cited.
CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement.
Chun Jing Wang, Frank Heuts, +7 authors, Lucy S K Walker.
Proc Natl Acad Sci U S A, 2014 Dec 31; 112(2). PMID: 25548162    Free PMC article.
Highly Cited.
Confusing signals: recent progress in CTLA-4 biology.
Lucy S K Walker, David M Sansom.
Trends Immunol, 2015 Jan 15; 36(2). PMID: 25582039    Free PMC article.
Highly Cited. Review.
Immune Checkpoint Blockade in Cancer Therapy.
Michael A Postow, Margaret K Callahan, Jedd D Wolchok.
J Clin Oncol, 2015 Jan 22; 33(17). PMID: 25605845    Free PMC article.
Highly Cited. Review.
A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.
Tie Zheng Hou, Omar S Qureshi, +4 authors, David M Sansom.
J Immunol, 2015 Jan 30; 194(5). PMID: 25632005    Free PMC article.
Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming.
Melanie P Matheu, Shivashankar Othy, +7 authors, Michael D Cahalan.
Nat Commun, 2015 Feb 06; 6. PMID: 25653051    Free PMC article.
Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma.
Rafael Winograd, Katelyn T Byrne, +8 authors, Robert H Vonderheide.
Cancer Immunol Res, 2015 Feb 14; 3(4). PMID: 25678581    Free PMC article.
Highly Cited.
Targeting the tumor microenvironment to enhance antitumor immune responses.
Kevin Van der Jeught, Lukasz Bialkowski, +7 authors, Karine Breckpot.
Oncotarget, 2015 Feb 16; 6(3). PMID: 25682197    Free PMC article.
Apical ballooning and cardiomyopathy in a melanoma patient treated with ipilimumab: a case of takotsubo-like syndrome.
Benjamin P Geisler, Roy A Raad, +2 authors, David R Schwartz.
J Immunother Cancer, 2015 Feb 24; 3. PMID: 25705383    Free PMC article.
Immunotherapy for lung cancer: for whom the bell tolls?
Pedro Madureira, Ramon Andrade de Mello, Alessandro de Vasconcelos, Yan Zhang.
Tumour Biol, 2015 Mar 05; 36(3). PMID: 25736929
OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal.
Stefanie N Linch, Michael J McNamara, William L Redmond.
Front Oncol, 2015 Mar 13; 5. PMID: 25763356    Free PMC article.
Highly Cited. Review.
The Role of Anti-PD-1/PD-L1 Agents in Melanoma: Progress to Date.
Katy K Tsai, Adil I Daud.
Drugs, 2015 Mar 25; 75(6). PMID: 25802230
Programmed cell death 1 and Helios distinguish TCR-αβ+ double-negative (CD4-CD8-) T cells that derive from self-reactive CD8 T cells.
Noé Rodríguez-Rodríguez, Sokratis A Apostolidis, +4 authors, José C Crispín.
J Immunol, 2015 Apr 01; 194(9). PMID: 25825451    Free PMC article.
Immune checkpoint blockade: a common denominator approach to cancer therapy.
Suzanne L Topalian, Charles G Drake, Drew M Pardoll.
Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858804    Free PMC article.
Highly Cited. Review.
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential.
Padmanee Sharma, James P Allison.
Cell, 2015 Apr 11; 161(2). PMID: 25860605    Free PMC article.
Highly Cited. Review.
Checkpoint modulation--A new way to direct the immune system against renal cell carcinoma.
Jens Bedke, Stephan Kruck, +2 authors, Peter J Goebell.
Hum Vaccin Immunother, 2015 Apr 29; 11(5). PMID: 25912622    Free PMC article.
A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy.
Robert D Leone, Ying-Chun Lo, Jonathan D Powell.
Comput Struct Biotechnol J, 2015 May 06; 13. PMID: 25941561    Free PMC article.
Highly Cited. Review.
Novel immune checkpoint blocker approved for the treatment of advanced melanoma.
Lorenzo Galluzzi, Guido Kroemer, Alexander Eggermont.
Oncoimmunology, 2015 May 06; 3(11). PMID: 25941597    Free PMC article.
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Jun Liu, Ying Yuan, +8 authors, Li Wang.
Proc Natl Acad Sci U S A, 2015 May 13; 112(21). PMID: 25964334    Free PMC article.
Highly Cited.
Immune checkpoint blockade and interferon-α in melanoma.
Imran Rafique, John M Kirkwood, Ahmad A Tarhini.
Semin Oncol, 2015 May 13; 42(3). PMID: 25965362    Free PMC article.
Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy.
Keishi Adachi, Koji Tamada.
Cancer Sci, 2015 May 20; 106(8). PMID: 25981182    Free PMC article.
Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia.
Hanna A Knaus, Christopher G Kanakry, Leo Luznik, Ivana Gojo.
Curr Drug Targets, 2015 May 20; 18(3). PMID: 25981611    Free PMC article.
Beyond adjuvants: immunomodulation strategies to enhance T cell immunity.
Alice O Kamphorst, Koichi Araki, Rafi Ahmed.
Vaccine, 2015 May 30; 33 Suppl 2. PMID: 26022562    Free PMC article.
Programmed death-1 checkpoint blockade in acute myeloid leukemia.
Alison Sehgal, Theresa L Whiteside, Michael Boyiadzis.
Expert Opin Biol Ther, 2015 Jun 04; 15(8). PMID: 26036819    Free PMC article.
IL-1R1 is expressed on both Helios(+) and Helios(-) FoxP3(+) CD4(+) T cells in the rheumatic joint.
M Müller, J Herrath, V Malmström.
Clin Exp Immunol, 2015 Jun 17; 182(1). PMID: 26076982    Free PMC article.
Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function.
Louisa E Jeffery, Omar S Qureshi, +6 authors, David M Sansom.
PLoS One, 2015 Jul 03; 10(7). PMID: 26134669    Free PMC article.
Inhibitory Receptors Beyond T Cell Exhaustion.
Silvia A Fuertes Marraco, Natalie J Neubert, Grégory Verdeil, Daniel E Speiser.
Front Immunol, 2015 Jul 15; 6. PMID: 26167163    Free PMC article.
Highly Cited. Review.
Associations between CTLA-4 +49 A/G (rs231775) polymorphism and cancer risk: a meta-analysis based on 52 case-control studies.
Lu Wang, Zhiwei Jiang, +3 authors, Lixin Wang.
Int J Clin Exp Med, 2015 Jul 30; 8(5). PMID: 26221222    Free PMC article.
Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion.
Greg M Delgoffe, Jonathan D Powell.
Mol Immunol, 2015 Aug 11; 68(2 Pt C). PMID: 26256793    Free PMC article.
1,25(OH)2D3 Promotes the Efficacy of CD28 Costimulation Blockade by Abatacept.
David H Gardner, Louisa E Jeffery, +4 authors, David M Sansom.
J Immunol, 2015 Aug 16; 195(6). PMID: 26276872    Free PMC article.
Cancer and the Immune System: Basic Concepts and Targets for Intervention.
Drew Pardoll.
Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320058    Free PMC article.
Highly Cited. Review.
Cancer immunotherapy: harnessing the immune system to battle cancer.
Yiping Yang.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325031    Free PMC article.
Highly Cited. Review.
Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future.
Lieping Chen, Xue Han.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325035    Free PMC article.
Highly Cited. Review.
Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis.
Anne Bertrand, Marie Kostine, +2 authors, Thierry Schaeverbeke.
BMC Med, 2015 Sep 05; 13. PMID: 26337719    Free PMC article.
Highly Cited. Systematic Review.
Cancer immunotherapy innovator James Allison receives the 2015 Lasker~DeBakey Clinical Medical Research Award.
Jillian H Hurst.
J Clin Invest, 2015 Sep 09; 125(10). PMID: 26345422    Free PMC article.
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.
Alison M Paterson, Scott B Lovitch, +9 authors, Arlene H Sharpe.
J Exp Med, 2015 Sep 16; 212(10). PMID: 26371185    Free PMC article.
Highly Cited.
Analysis of DLA-DQB1 and polymorphisms in CTLA4 in Cocker spaniels affected with immune-mediated haemolytic anaemia.
Anna J Threlfall, Alisdair M Boag, +3 authors, Brian Catchpole.
Canine Genet Epidemiol, 2015 Sep 25; 2. PMID: 26401336    Free PMC article.
Identifying genetic determinants of autoimmunity and immune dysregulation.
Carrie L Lucas, Michael J Lenardo.
Curr Opin Immunol, 2015 Oct 05; 37. PMID: 26433354    Free PMC article.
Advances in immunotherapy for treatment of lung cancer.
Jean G Bustamante Alvarez, María González-Cao, +4 authors, Rafael Rosell.
Cancer Biol Med, 2015 Oct 22; 12(3). PMID: 26487966    Free PMC article.
Novel immunotherapies in lymphoid malignancies.
Connie Lee Batlevi, Eri Matsuki, Renier J Brentjens, Anas Younes.
Nat Rev Clin Oncol, 2015 Nov 04; 13(1). PMID: 26525683    Free PMC article.
Highly Cited. Review.
Immune-checkpoint blockade: the springboard for immuno-combination therapy.
A M Ibrahim, Y Wang, N R Lemoine.
Gene Ther, 2015 Nov 06; 22(11). PMID: 26537748
Immune dysfunction in acute alcoholic hepatitis.
Ashwin D Dhanda, Peter L Collins.
World J Gastroenterol, 2015 Nov 18; 21(42). PMID: 26576079    Free PMC article.
Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy.
Anna Śledzińska, Laurie Menger, +2 authors, Sergio A Quezada.
Mol Oncol, 2015 Nov 19; 9(10). PMID: 26578451    Free PMC article.
Harnessing the Power of Onco-Immunotherapy with Checkpoint Inhibitors.
Karishma R Rajani, Richard G Vile.
Viruses, 2015 Nov 19; 7(11). PMID: 26580645    Free PMC article.
Glutamate Receptor Interacting Protein 1 Regulates CD4(+) CTLA-4 Expression and Transplant Rejection.
K L Modjeski, S C Levy, +5 authors, C N Morrell.
Am J Transplant, 2015 Nov 26; 16(5). PMID: 26601915    Free PMC article.
Melanoma: oncogenic drivers and the immune system.
Niki Karachaliou, Sara Pilotto, +10 authors, Rafael Rosell.
Ann Transl Med, 2015 Nov 26; 3(18). PMID: 26605311    Free PMC article.
Polymorphisms of co-inhibitory molecules (CTLA-4/PD-1/PD-L1) and the risk of non-small cell lung cancer in a Chinese population.
Yuan Ma, Xiuchun Liu, +6 authors, Liu Jie.
Int J Clin Exp Med, 2015 Dec 03; 8(9). PMID: 26629188    Free PMC article.
Genomics of Immune Diseases and New Therapies.
Michael Lenardo, Bernice Lo, Carrie L Lucas.
Annu Rev Immunol, 2016 Jan 07; 34. PMID: 26735698    Free PMC article.
γδ T Cells Protect the Liver and Lungs of Mice from Autoimmunity Induced by Scurfy Lymphocytes.
Hideyuki Ujiie, Ethan M Shevach.
J Immunol, 2016 Jan 17; 196(4). PMID: 26773142    Free PMC article.
Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes.
Kerstin Sarter, Elisa Leimgruber, +16 authors, Walter Reith.
J Exp Med, 2016 Jan 27; 213(2). PMID: 26809444    Free PMC article.
Viro-immune therapy: A new strategy for treatment of pancreatic cancer.
Andrea Marie Ibrahim, Yao-He Wang.
World J Gastroenterol, 2016 Jan 27; 22(2). PMID: 26811622    Free PMC article.
Disrupted regulatory T cell homeostasis in inflammatory bowel diseases.
Christophe Pedros, Fanny Duguet, Abdelhadi Saoudi, Marianne Chabod.
World J Gastroenterol, 2016 Jan 27; 22(3). PMID: 26811641    Free PMC article.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too?
Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella.
Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028    Free PMC article.
Basics of PD-1 in self-tolerance, infection, and cancer immunity.
Shunsuke Chikuma.
Int J Clin Oncol, 2016 Feb 13; 21(3). PMID: 26864303
Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand Recognition.
Joanna Brzostek, Nicholas R J Gascoigne, Vasily Rybakin.
Front Immunol, 2016 Feb 13; 7. PMID: 26870040    Free PMC article.
Tumor CTLA-4 overexpression predicts poor survival in patients with nasopharyngeal carcinoma.
Pei-Yu Huang, Shan-Shan Guo, +7 authors, Hai-Qiang Mai.
Oncotarget, 2016 Feb 27; 7(11). PMID: 26918337    Free PMC article.
Blocking immune checkpoints in prostate, kidney, and urothelial cancer: An overview.
Angela K B Alme, Beerinder S Karir, Bishoy M Faltas, Charles G Drake.
Urol Oncol, 2016 Mar 01; 34(4). PMID: 26923782    Free PMC article.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.
Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok.
Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780    Free PMC article.
Highly Cited. Review.
Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7.
Matthew M Halpert, Vanaja Konduri, +5 authors, William K Decker.
Stem Cells Dev, 2016 Mar 17; 25(10). PMID: 26979751    Free PMC article.
Combining Epigenetic and Immunotherapy to Combat Cancer.
Katherine B Chiappinelli, Cynthia A Zahnow, Nita Ahuja, Stephen B Baylin.
Cancer Res, 2016 Mar 19; 76(7). PMID: 26988985    Free PMC article.
Highly Cited. Review.
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood.
Katrin Klocke, Shimon Sakaguchi, Rikard Holmdahl, Kajsa Wing.
Proc Natl Acad Sci U S A, 2016 Apr 14; 113(17). PMID: 27071130    Free PMC article.
Highly Cited.
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy.
Suzanne L Topalian, Janis M Taube, Robert A Anders, Drew M Pardoll.
Nat Rev Cancer, 2016 Apr 16; 16(5). PMID: 27079802    Free PMC article.
Highly Cited. Review.
Effect of CTLA-4 gene polymorphisms on long-term kidney allograft function in Han Chinese recipients.
Yifeng Guo, Junwei Gao, +2 authors, Fang Guo.
Oncotarget, 2016 Apr 16; 7(17). PMID: 27081086    Free PMC article.
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.
Jianxun Wang, Masayuki Mizui, +7 authors, Maria I Kontaridis.
J Clin Invest, 2016 May 18; 126(6). PMID: 27183387    Free PMC article.
Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.
Frank A Schildberg, Sarah R Klein, Gordon J Freeman, Arlene H Sharpe.
Immunity, 2016 May 19; 44(5). PMID: 27192563    Free PMC article.
Highly Cited. Review.
CD28 Costimulation: From Mechanism to Therapy.
Jonathan H Esensten, Ynes A Helou, +2 authors, Jeffrey A Bluestone.
Immunity, 2016 May 19; 44(5). PMID: 27192564    Free PMC article.
Highly Cited. Review.
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.
Ana C Anderson, Nicole Joller, Vijay K Kuchroo.
Immunity, 2016 May 19; 44(5). PMID: 27192565    Free PMC article.
Highly Cited. Review.
Progress and challenges for treating Type 1 diabetes.
Justin W Garyu, Eric Meffre, Chris Cotsapas, Kevan C Herold.
J Autoimmun, 2016 May 24; 71. PMID: 27210268    Free PMC article.
Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells.
Ewa Kozela, Ana Juknat, +3 authors, Zvi Vogel.
J Neuroinflammation, 2016 Jun 04; 13(1). PMID: 27256343    Free PMC article.
Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis.
Jessica Harakal, Claudia Rival, Hui Qiao, Kenneth S Tung.
J Immunol, 2016 Jun 05; 197(1). PMID: 27259856    Free PMC article.
Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma.
Naoka Murakami, Thiago J Borges, Michifumi Yamashita, Leonardo V Riella.
Clin Kidney J, 2016 Jun 09; 9(3). PMID: 27274826    Free PMC article.
What does the future hold for immunotherapy in cancer?
Jarushka Naidoo, Bob T Li, Katja Schindler, David B Page.
Ann Transl Med, 2016 Jun 09; 4(9). PMID: 27275490    Free PMC article.
Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors.
Frank B Cortazar, Kristen A Marrone, +15 authors, David E Leaf.
Kidney Int, 2016 Jun 11; 90(3). PMID: 27282937    Free PMC article.
Highly Cited.
Unintended Immunological Consequences of Biologic Therapy.
Sarah E Henrickson, Melanie A Ruffner, Mildred Kwan.
Curr Allergy Asthma Rep, 2016 Jun 22; 16(6). PMID: 27324478    Free PMC article.
Insights into the development and regulation of T follicular helper cells.
Shradha Wali, Anupama Sahoo, +2 authors, Roza Nurieva.
Cytokine, 2016 Jun 25; 87. PMID: 27339151    Free PMC article.
The immune microenvironment in Hodgkin lymphoma: T cells, B cells, and immune checkpoints.
Santosha Vardhana, Anas Younes.
Haematologica, 2016 Jul 02; 101(7). PMID: 27365459    Free PMC article.
CHAI and LATAIE: new genetic diseases of CTLA-4 checkpoint insufficiency.
Bernice Lo, Jill M Fritz, +3 authors, Michael J Lenardo.
Blood, 2016 Jul 16; 128(8). PMID: 27418640    Free PMC article.
Metastatic melanoma and immunotherapy.
Benjamin Herzberg, David E Fisher.
Clin Immunol, 2016 Jul 20; 172. PMID: 27430520    Free PMC article.
Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer.
Robert Gibson, Jess Delaune, Anita Szady, Merry Markham.
BMJ Case Rep, 2016 Jul 22; 2016. PMID: 27440853    Free PMC article.
Empowering Regulatory T Cells in Autoimmunity.
Isaac R Kasper, Sokratis A Apostolidis, Amir Sharabi, George C Tsokos.
Trends Mol Med, 2016 Jul 28; 22(9). PMID: 27461103    Free PMC article.
CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma.
Guang-Tao Yu, Lin-Lin Bu, +5 authors, Zhi-Jun Sun.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471622    Free PMC article.
Immunotherapy in genitourinary malignancies.
Max M Wattenberg, Lawrence Fong, Ravi A Madan, James L Gulley.
Curr Opin Urol, 2016 Jul 30; 26(6). PMID: 27471994    Free PMC article.
Emerging options for the treatment of melanoma - focus on ipilimumab.
Claire Roddie, Karl S Peggs.
Immunotargets Ther, 2014 Jan 01; 3. PMID: 27482517    Free PMC article.
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.
Lewis Zhichang Shi, Tihui Fu, +7 authors, Padmanee Sharma.
Nat Commun, 2016 Aug 09; 7. PMID: 27498556    Free PMC article.
MiRNA in atopic dermatitis.
Michał Rożalski, Lidia Rudnicka, Zbigniew Samochocki.
Postepy Dermatol Alergol, 2016 Aug 12; 33(3). PMID: 27512348    Free PMC article.
Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy.
Lucie Heinzerling, Patrick A Ott, +7 authors, Jason J Luke.
J Immunother Cancer, 2016 Aug 18; 4. PMID: 27532025    Free PMC article.
Highly Cited.
Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer.
Benjamin Herzberg, Meghan J Campo, Justin F Gainor.
Oncologist, 2016 Aug 19; 22(1). PMID: 27534574    Free PMC article.
Rare phenotypes in the understanding of autoimmunity.
Yvonne Zeissig, Britt-Sabina Petersen, +2 authors, Sebastian Zeissig.
Immunol Cell Biol, 2016 Aug 27; 94(10). PMID: 27562064    Free PMC article.
Melanoma immunotherapy dominates the field.
Panagiotis Diamantopoulos, Helen Gogas.
Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563656    Free PMC article.
Ipilimumab-Induced Neutropenia in Melanoma.
Makiko Ban-Hoefen, Richard Burack, Lynn Sievert, Deepak Sahasrabudhe.
J Investig Med High Impact Case Rep, 2016 Aug 30; 4(3). PMID: 27570779    Free PMC article.
Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway.
Andrew B Adams, Mandy L Ford, Christian P Larsen.
J Immunol, 2016 Sep 04; 197(6). PMID: 27591335    Free PMC article.
Specific CD8(+) T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis.
Elia Moreno-Cubero, Juan-Ramón Larrubia.
World J Gastroenterol, 2016 Sep 09; 22(28). PMID: 27605882    Free PMC article.
Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling.
Melanie R Hassler, Walter Pulverer, +11 authors, Gerda Egger.
Cell Rep, 2016 Oct 06; 17(2). PMID: 27705804    Free PMC article.
Association of CD247 (CD3ζ) gene polymorphisms with T1D and AITD in the population of northern Sweden.
Dan Holmberg, Karin Ruikka, +2 authors, Sofia Mayans.
BMC Med Genet, 2016 Oct 08; 17(1). PMID: 27716086    Free PMC article.
Unbalanced Immune System: Immunodeficiencies and Autoimmunity.
Giuliana Giardino, Vera Gallo, +10 authors, Claudio Pignata.
Front Pediatr, 2016 Oct 22; 4. PMID: 27766253    Free PMC article.
miR-155: A Novel Target in Allergic Asthma.
Hong Zhou, Junyao Li, +2 authors, Jie Zhang.
Int J Mol Sci, 2016 Oct 27; 17(10). PMID: 27783037    Free PMC article.
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway.
Vassiliki A Boussiotis.
N Engl J Med, 2016 Nov 03; 375(18). PMID: 27806234    Free PMC article.
Highly Cited. Review.
Are Regulatory T Cells Defective in Type 1 Diabetes and Can We Fix Them?
Anabelle Visperas, Dario A A Vignali.
J Immunol, 2016 Nov 07; 197(10). PMID: 27815439    Free PMC article.
Ipilimumab: from preclinical development to future clinical perspectives in melanoma.
Paul Letendre, Varun Monga, Mohammed Milhem, Yousef Zakharia.
Future Oncol, 2016 Nov 25; 13(7). PMID: 27882779    Free PMC article.
Advances in Cancer Immunotherapy in Solid Tumors.
Smitha Menon, Sarah Shin, Grace Dy.
Cancers (Basel), 2016 Nov 26; 8(12). PMID: 27886124    Free PMC article.
Highly Cited. Review.
Promising Novel Agents for Aggressive B-Cell Lymphoma.
Anas Younes.
Hematol Oncol Clin North Am, 2016 Nov 28; 30(6). PMID: 27888877    Free PMC article.
Checkpoint inhibition in myeloma.
Don M Benson.
Hematology Am Soc Hematol Educ Program, 2016 Dec 04; 2016(1). PMID: 27913525    Free PMC article.
Osteosarcoma Overview.
Brock A Lindsey, Justin E Markel, Eugenie S Kleinerman.
Rheumatol Ther, 2016 Dec 10; 4(1). PMID: 27933467    Free PMC article.
Highly Cited. Review.
The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation.
Kankana Bardhan, Theodora Anagnostou, Vassiliki A Boussiotis.
Front Immunol, 2016 Dec 27; 7. PMID: 28018338    Free PMC article.
Highly Cited. Review.
Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire.
David Y Oh, Jason Cham, +5 authors, Lawrence Fong.
Cancer Res, 2016 Dec 30; 77(6). PMID: 28031229    Free PMC article.
A phase IB study of ipilimumab with peginterferon alfa-2b in patients with unresectable melanoma.
Andrew S Brohl, Nikhil I Khushalani, +5 authors, Jeffrey S Weber.
J Immunother Cancer, 2016 Dec 30; 4. PMID: 28031816    Free PMC article.
A New VISTA on combination therapy for negative checkpoint regulator blockade.
Jie Deng, Isabelle Le Mercier, Anna Kuta, Randolph J Noelle.
J Immunother Cancer, 2016 Dec 30; 4. PMID: 28031817    Free PMC article.
TCR Signaling and CD28/CTLA-4 Signaling Cooperatively Modulate T Regulatory Cell Homeostasis.
Michael P Holt, George A Punkosdy, Deborah D Glass, Ethan M Shevach.
J Immunol, 2017 Jan 06; 198(4). PMID: 28053234    Free PMC article.
T cell exhaustion: from pathophysiological basics to tumor immunotherapy.
Kemal Catakovic, Eckhard Klieser, Daniel Neureiter, Roland Geisberger.
Cell Commun Signal, 2017 Jan 12; 15(1). PMID: 28073373    Free PMC article.
Highly Cited. Review.
PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective.
Jun Wang, Ruirong Yuan, +3 authors, Zihai Li.
J Hematol Oncol, 2017 Jan 27; 10(1). PMID: 28122590    Free PMC article.
Highly Cited. Review.
Gastrointestinal and Hepatic Complications of Immune Checkpoint Inhibitors.
Peyton Cramer, Robert S Bresalier.
Curr Gastroenterol Rep, 2017 Jan 27; 19(1). PMID: 28124291
Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.
Tie Zheng Hou, Nisha Verma, +17 authors, David M Sansom.
Blood, 2017 Feb 06; 129(11). PMID: 28159733    Free PMC article.
Renal complications of immune checkpoint blockade.
Naoka Murakami, Shveta Motwani, Leonardo V Riella.
Curr Probl Cancer, 2017 Feb 13; 41(2). PMID: 28189263    Free PMC article.
Emerging role of checkpoint blockade therapy in lymphoma.
Natalie Galanina, Justin Kline, Michael R Bishop.
Ther Adv Hematol, 2017 Feb 17; 8(2). PMID: 28203344    Free PMC article.
Targeting PD-1/PD-L1 in lung cancer: current perspectives.
María González-Cao, Niki Karachaliou, +6 authors, Rafael Rosell.
Lung Cancer (Auckl), 2015 Jul 31; 6. PMID: 28210151    Free PMC article.
Cardiovascular Toxicities Associated with Cancer Immunotherapies.
Daniel Y Wang, Gosife Donald Okoye, +2 authors, Javid J Moslehi.
Curr Cardiol Rep, 2017 Feb 22; 19(3). PMID: 28220466
Highly Cited. Review.
Introduction to checkpoint inhibitors and cancer immunotherapy.
Arlene H Sharpe.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258698    Free PMC article.
Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma.
Liliana E Lucca, David A Hafler.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258696    Free PMC article.
Tim-3 and its role in regulating anti-tumor immunity.
Madhumita Das, Chen Zhu, Vijay K Kuchroo.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258697    Free PMC article.
Highly Cited. Review.
Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy.
Leslie S Kean, Laurence A Turka, Bruce R Blazar.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258702    Free PMC article.
Immune checkpoint inhibition and its relationship with hypermutation phenoytype as a potential treatment for Glioblastoma.
Manohan Sinnadurai, Kerrie L McDonald.
J Neurooncol, 2017 Mar 16; 132(3). PMID: 28293764
Multiscale Modeling of Complex Formation and CD80 Depletion during Immune Synapse Development.
István P Sugár, Jayajit Das, Ciriyam Jayaprakash, Stuart C Sealfon.
Biophys J, 2017 Mar 16; 112(5). PMID: 28297658    Free PMC article.
Mechanistic and pharmacologic insights on immune checkpoint inhibitors.
Randy F Sweis, Jason J Luke.
Pharmacol Res, 2017 Mar 23; 120. PMID: 28323141    Free PMC article.
Biological mechanisms of immune escape and implications for immunotherapy in head and neck squamous cell carcinoma.
Jennifer D Moy, Jessica M Moskovitz, Robert L Ferris.
Eur J Cancer, 2017 Mar 23; 76. PMID: 28324750    Free PMC article.
ATVB Distinguished Scientist Award: How Costimulatory and Coinhibitory Pathways Shape Atherosclerosis.
Klaus Ley, Norbert Gerdes, Holger Winkels.
Arterioscler Thromb Vasc Biol, 2017 Apr 01; 37(5). PMID: 28360089    Free PMC article.
Research and therapeutics-traditional and emerging therapies in systemic lupus erythematosus.
Laurie S Davis, Andreas M Reimold.
Rheumatology (Oxford), 2017 Apr 05; 56(suppl_1). PMID: 28375452    Free PMC article.
CD8 T-cell regulation by T regulatory cells and the programmed cell death protein 1 pathway.
Pablo Penaloza-MacMaster.
Immunology, 2017 Apr 05; 151(2). PMID: 28375543    Free PMC article.
Cutting Edge: Increased Autoimmunity Risk in Glycogen Storage Disease Type 1b Is Associated with a Reduced Engagement of Glycolysis in T Cells and an Impaired Regulatory T Cell Function.
Daniela Melis, Fortunata Carbone, +7 authors, Giuseppe Matarese.
J Immunol, 2017 Apr 09; 198(10). PMID: 28389590    Free PMC article.
Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses.
Nikolaos Patsoukis, Jessica D Weaver, +3 authors, Vassiliki A Boussiotis.
Front Immunol, 2017 Apr 27; 8. PMID: 28443090    Free PMC article.
Checkpoint inhibitors in hematological malignancies.
Chi Young Ok, Ken H Young.
J Hematol Oncol, 2017 May 10; 10(1). PMID: 28482851    Free PMC article.
Highly Cited. Review.
CTLA-4 expressed by FOXP3+ regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis.
Katrin Klocke, Rikard Holmdahl, Kajsa Wing.
Immunology, 2017 May 13; 152(1). PMID: 28497863    Free PMC article.
Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice.
Takuma Suzuki, Shohei Murakami, +4 authors, Hozumi Motohashi.
Mol Cell Biol, 2017 May 17; 37(15). PMID: 28507037    Free PMC article.
Challenges and opportunities in targeting the CD28/CTLA-4 pathway in transplantation and autoimmunity.
Rebecca L Crepeau, Mandy L Ford.
Expert Opin Biol Ther, 2017 May 21; 17(8). PMID: 28525959    Free PMC article.
Mini-review of conventional and hypofractionated radiation therapy combined with immunotherapy for non-small cell lung cancer.
Allison M Campbell, Roy H Decker.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529904    Free PMC article.
Immune deficiency and autoimmunity in patients with CTLA-4 (CD152) mutations.
N Verma, S O Burns, L S K Walker, D M Sansom.
Clin Exp Immunol, 2017 Jun 11; 190(1). PMID: 28600865    Free PMC article.
Pembrolizumab in cervical cancer: latest evidence and clinical usefulness.
Edith Borcoman, Christophe Le Tourneau.
Ther Adv Med Oncol, 2017 Jun 14; 9(6). PMID: 28607581    Free PMC article.
Pembrolizumab-Induced Thyroiditis: Comprehensive Clinical Review and Insights Into Underlying Involved Mechanisms.
Danae A Delivanis, Michael P Gustafson, +5 authors, Mabel Ryder.
J Clin Endocrinol Metab, 2017 Jun 15; 102(8). PMID: 28609832    Free PMC article.
Highly Cited.
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.
Sebastian Peer, Gottfried Baier, Thomas Gruber.
Oncotarget, 2017 Jun 15; 8(26). PMID: 28611299    Free PMC article.
Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation.
Deborah L Burnett, Ian A Parish, +2 authors, Christopher C Goodnow.
Immunol Cell Biol, 2017 Jun 15; 95(9). PMID: 28611475    Free PMC article.
Selective CD28 Blockade Results in Superior Inhibition of Donor-Specific T Follicular Helper Cell and Antibody Responses Relative to CTLA4-Ig.
I R Badell, G M La Muraglia, +3 authors, M L Ford.
Am J Transplant, 2017 Jun 22; 18(1). PMID: 28637095    Free PMC article.
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors.
Andrew Gibson, Lee Faulkner, +8 authors, Dean J Naisbitt.
J Immunol, 2017 Jul 09; 199(4). PMID: 28687658    Free PMC article.
Programmed Cell Death 1 (PD-1) and Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) in Viral Hepatitis.
Hyosun Cho, Hyojeung Kang, Hwan Hee Lee, Chang Wook Kim.
Int J Mol Sci, 2017 Jul 14; 18(7). PMID: 28703774    Free PMC article.
Current Advances in Checkpoint Inhibitors: Lessons from Non-Central Nervous System Cancers and Potential for Glioblastoma.
Natasha Lakin, Robert Rulach, Stefan Nowicki, Kathreena M Kurian.
Front Oncol, 2017 Jul 22; 7. PMID: 28730140    Free PMC article.
The promise of immunotherapy in head and neck squamous cell carcinoma: combinatorial immunotherapy approaches.
Panagiota Economopoulou, Ioannis Kotsantis, Amanda Psyrri.
ESMO Open, 2017 Aug 30; 1(6). PMID: 28848660    Free PMC article.
Immune checkpoint inhibitors in cancer therapy.
Eika S Webb, Peng Liu, +3 authors, Yao-He Wang.
J Biomed Res, 2017 Sep 04; 32(5). PMID: 28866656    Free PMC article.
Tim-3, Lag-3, and TIGIT.
Nicole Joller, Vijay K Kuchroo.
Curr Top Microbiol Immunol, 2017 Sep 14; 410. PMID: 28900677    Free PMC article.
Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity.
Pearl Bakhru, Meng-Lei Zhu, +14 authors, Maureen A Su.
JCI Insight, 2017 Sep 22; 2(18). PMID: 28931755    Free PMC article.
The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part I: Treg properties and functions.
Bogusław Nedoszytko, Magdalena Lange, +10 authors, Roman Nowicki.
Postepy Dermatol Alergol, 2017 Sep 28; 34(4). PMID: 28951701    Free PMC article.
PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients.
Mohammad S Hossain, Ghada M Kunter, +5 authors, Edmund K Waller.
PLoS One, 2017 Sep 28; 12(9). PMID: 28953925    Free PMC article.
Checkpoint Inhibitors: Applications for Autoimmunity.
Anna S Tocheva, Adam Mor.
Curr Allergy Asthma Rep, 2017 Sep 29; 17(10). PMID: 28956259    Free PMC article.
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Romualdo Barroso-Sousa, William T Barry, +4 authors, Sara M Tolaney.
JAMA Oncol, 2017 Oct 04; 4(2). PMID: 28973656    Free PMC article.
Highly Cited. Systematic Review.
Control of NK Cell Activation by Immune Checkpoint Molecules.
Asma Beldi-Ferchiou, Sophie Caillat-Zucman.
Int J Mol Sci, 2017 Oct 13; 18(10). PMID: 29023417    Free PMC article.
Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer.
Isobel S Okoye, Michael Houghton, +2 authors, Shokrollah Elahi.
Front Immunol, 2017 Oct 17; 8. PMID: 29033936    Free PMC article.
Clinical features, predictive correlates, and pathophysiology of immune-related adverse events in immune checkpoint inhibitor treatments in cancer: a short review.
Jennifer M Yoest.
Immunotargets Ther, 2017 Oct 27; 6. PMID: 29067284    Free PMC article.
Immune checkpoint inhibitors in renal cell carcinoma.
Kirsty Ross, Rob J Jones.
Clin Sci (Lond), 2017 Oct 29; 131(21). PMID: 29079639    Free PMC article.
Cardiotoxicity of immune checkpoint inhibitors.
Gilda Varricchi, Maria Rosaria Galdiero, +5 authors, Carlo Gabriele Tocchetti.
ESMO Open, 2017 Nov 07; 2(4). PMID: 29104763    Free PMC article.
Highly Cited. Review.
T Cell-Mediated Chronic Inflammatory Diseases Are Candidates for Therapeutic Tolerance Induction with Heat Shock Proteins.
Ariana Barbera Betancourt, Qingkang Lyu, +3 authors, Willem van Eden.
Front Immunol, 2017 Nov 11; 8. PMID: 29123529    Free PMC article.
Immune checkpoint inhibitors: new strategies to checkmate cancer.
R A M Wilson, T R J Evans, A R Fraser, R J B Nibbs.
Clin Exp Immunol, 2017 Nov 16; 191(2). PMID: 29139554    Free PMC article.
Checkpoint blockade in solid tumors and B-cell malignancies, with special consideration of the role of CD200.
Reginald M Gorczynski, Fang Zhu.
Cancer Manag Res, 2017 Nov 29; 9. PMID: 29180896    Free PMC article.
Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4.
Bi Shi, Jianlin Geng, +9 authors, Hui Hu.
J Immunol, 2017 Dec 08; 200(2). PMID: 29212910    Free PMC article.
Checkpoint Blockade Toxicity and Immune Homeostasis in the Gastrointestinal Tract.
Michael Dougan.
Front Immunol, 2017 Dec 13; 8. PMID: 29230210    Free PMC article.
Highly Cited. Review.
Advances in T-cell checkpoint immunotherapy for head and neck squamous cell carcinoma.
Xinmeng Qi, Bo Jia, Xue Zhao, Dan Yu.
Onco Targets Ther, 2017 Dec 15; 10. PMID: 29238207    Free PMC article.
PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?
Zijun Y Xu-Monette, Mingzhi Zhang, Jianyong Li, Ken H Young.
Front Immunol, 2017 Dec 20; 8. PMID: 29255458    Free PMC article.
Highly Cited. Review.
Novel immunotherapy approaches for metastatic urothelial and renal cell carcinoma.
Zhiying Shao, Andrew Z Wang, Daniel J George, Tian Zhang.
Asian J Urol, 2016 Oct 01; 3(4). PMID: 29264195    Free PMC article.
Recent Successes and Future Directions in Immunotherapy of Cutaneous Melanoma.
Hassan Sadozai, Thomas Gruber, Robert Emil Hunger, Mirjam Schenk.
Front Immunol, 2017 Dec 26; 8. PMID: 29276510    Free PMC article.
Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model.
Cameron S Field, Martin K Hunn, +3 authors, Ian F Hermans.
Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296535    Free PMC article.
Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade.
Jie Bai, Zhitao Gao, +3 authors, Jing Nie.
Oncotarget, 2018 Jan 05; 8(66). PMID: 29299180    Free PMC article.
CTLA-4 polymorphisms: influence on transplant-related mortality and survival in children undergoing allogeneic hematopoietic stem cell transplantation.
Judith Hammrich, Susan Wittig, Thomas Ernst, Bernd Gruhn.
J Cancer Res Clin Oncol, 2018 Jan 18; 144(3). PMID: 29335768
Regulatory T Cell Metabolism in the Hepatic Microenvironment.
Rebecca Ellen Wawman, Helen Bartlett, Ye Htun Oo.
Front Immunol, 2018 Jan 24; 8. PMID: 29358934    Free PMC article.
Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokines.
Jason Miska, Jen Bon Lui, +7 authors, Zhibin Chen.
J Exp Med, 2018 Jan 28; 215(3). PMID: 29374027    Free PMC article.
The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation.
Wenwen Xu, TạMinh Hiếu, Subramaniam Malarkannan, Li Wang.
Cell Mol Immunol, 2018 Jan 30; 15(5). PMID: 29375120    Free PMC article.
A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis.
Eleanor A Fallon, Bethany M Biron-Girard, +4 authors, Alfred Ayala.
J Leukoc Biol, 2018 Feb 03;. PMID: 29393983    Free PMC article.
Cancer Immunotherapy: Factors Important for the Evaluation of Safety in Nonclinical Studies.
Danuta J Herzyk, Helen G Haggerty.
AAPS J, 2018 Feb 09; 20(2). PMID: 29417397
Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice.
Xuexiang Du, Mingyue Liu, +8 authors, Pan Zheng.
Cell Res, 2018 Feb 22; 28(4). PMID: 29463898    Free PMC article.
Highly Cited.
A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy.
Xuexiang Du, Fei Tang, +14 authors, Yang Liu.
Cell Res, 2018 Feb 24; 28(4). PMID: 29472691    Free PMC article.
Highly Cited.
Human FOXP3+ T regulatory cell heterogeneity.
Audrey Mohr, Rajneesh Malhotra, +2 authors, Makoto Miyara.
Clin Transl Immunology, 2018 Feb 28; 7(1). PMID: 29484183    Free PMC article.
Highly Cited. Review.
Importance of immune monitoring approaches and the use of immune checkpoints for the treatment of diffuse intrinsic pontine glioma: From bench to clinic and vice versa (Review).
Jorge Augusto Borin Scutti.
Int J Oncol, 2018 Feb 28; 52(4). PMID: 29484440    Free PMC article.
Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients.
Priyanka B Subrahmanyam, Zhiwan Dong, +7 authors, F Stephen Hodi.
J Immunother Cancer, 2018 Mar 08; 6(1). PMID: 29510697    Free PMC article.
Highly Cited.
Gastrointestinal toxicity of immune checkpoint inhibitors: from mechanisms to management.
Mark A Samaan, Polychronis Pavlidis, +2 authors, Peter M Irving.
Nat Rev Gastroenterol Hepatol, 2018 Mar 08; 15(4). PMID: 29512649
Donor-Derived Regulatory Dendritic Cell Infusion Maintains Donor-Reactive CD4+CTLA4hi T Cells in Non-Human Primate Renal Allograft Recipients Treated with CD28 Co-Stimulation Blockade.
Mohamed B Ezzelarab, Lien Lu, +2 authors, Angus W Thomson.
Front Immunol, 2018 Mar 10; 9. PMID: 29520267    Free PMC article.
Mechanisms of Immune Evasion and Immune Modulation by Lymphoma Cells.
Thomas Menter, Alexandar Tzankov.
Front Oncol, 2018 Mar 23; 8. PMID: 29564225    Free PMC article.
Anti-CTLA-4 therapy requires an Fc domain for efficacy.
Jessica R Ingram, Olga S Blomberg, +15 authors, Michael Dougan.
Proc Natl Acad Sci U S A, 2018 Mar 28; 115(15). PMID: 29581255    Free PMC article.
Highly Cited.
Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody.
Randi B Gombos, Ana Gonzalez, +24 authors, Nicholas S Wilson.
PLoS One, 2018 Apr 05; 13(4). PMID: 29617360    Free PMC article.
Sex and interleukin-6 are prognostic factors for autoimmune toxicity following treatment with anti-CTLA4 blockade.
Sara Valpione, Sandro Pasquali, +4 authors, Vanna Chiarion-Sileni.
J Transl Med, 2018 Apr 13; 16(1). PMID: 29642948    Free PMC article.
Expression of immune checkpoint regulators, cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed death-ligand 1 (PD-L1), in female breast carcinomas.
Ari Kassardjian, Peter I Shintaku, Neda A Moatamed.
PLoS One, 2018 Apr 20; 13(4). PMID: 29672601    Free PMC article.
Regulatory T Cells As Potential Targets for HIV Cure Research.
Adam J Kleinman, Ranjit Sivanandham, +2 authors, Cristian Apetrei.
Front Immunol, 2018 May 01; 9. PMID: 29706961    Free PMC article.
T Follicular Regulatory Cells and Antibody Responses in Transplantation.
Elizabeth F Wallin.
Transplantation, 2018 May 15; 102(10). PMID: 29757907    Free PMC article.
CTLA‑4 interferes with the HBV‑specific T cell immune response (Review).
Hui Cao, Ruiwen Zhang, Wei Zhang.
Int J Mol Med, 2018 May 23; 42(2). PMID: 29786112    Free PMC article.
Treatment of Intracerebral Lesions with Abatacept in a CTLA4-Haploinsufficient Patient.
Ester M van Leeuwen, Eloy Cuadrado, +2 authors, Godelieve J de Bree.
J Clin Immunol, 2018 May 26; 38(4). PMID: 29796761
Therapeutic Antibodies for Myeloid Neoplasms-Current Developments and Future Directions.
Christian M Schürch.
Front Oncol, 2018 Jun 06; 8. PMID: 29868474    Free PMC article.
Emerging Functions of Regulatory T Cells in Tissue Homeostasis.
Amit Sharma, Dipayan Rudra.
Front Immunol, 2018 Jun 12; 9. PMID: 29887862    Free PMC article.
Highly Cited. Review.
Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis.
Heidi Harjunpää, Stephen J Blake, +12 authors, Michele W L Teng.
Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900061    Free PMC article.
Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors.
Angeliki M Stamatouli, Zoe Quandt, +11 authors, Kevan C Herold.
Diabetes, 2018 Jun 26; 67(8). PMID: 29937434    Free PMC article.
Highly Cited. Review.
The Treatment of Inflammatory Bowel Disease in Patients with Selected Primary Immunodeficiencies.
Dror S Shouval, Matthew Kowalik, Scott B Snapper.
J Clin Immunol, 2018 Jun 30; 38(5). PMID: 29956079
Bacille Calmette-Guerin Complications in Newly Described Primary Immunodeficiency Diseases: 2010-2017.
Cristiane de Jesus Nunes-Santos, Sergio D Rosenzweig.
Front Immunol, 2018 Jul 11; 9. PMID: 29988375    Free PMC article.
Regulatory T cells control epitope spreading in autoimmune arthritis independent of cytotoxic T-lymphocyte antigen-4.
Min Yang, Katrin Klocke, +4 authors, Rikard Holmdahl.
Immunology, 2018 Jul 12; 155(4). PMID: 29992549    Free PMC article.
Autoantigen-Harboring Apoptotic Cells Hijack the Coinhibitory Pathway of T Cell Activation.
Abraam M Yakoub, Ralph Schulz, Martina Seiffert, Mark Sadek.
Sci Rep, 2018 Jul 14; 8(1). PMID: 30002409    Free PMC article.
Management of Brain Metastases in the New Era of Checkpoint Inhibition.
Adam Lauko, Bicky Thapa, Vyshak Alva Venur, Manmeet S Ahluwalia.
Curr Neurol Neurosci Rep, 2018 Aug 20; 18(10). PMID: 30121715
Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options.
Derya Kabacaoglu, Katrin J Ciecielski, Dietrich A Ruess, Hana Algül.
Front Immunol, 2018 Aug 31; 9. PMID: 30158932    Free PMC article.
Insights Into the Molecular Mechanisms of T Follicular Helper-Mediated Immunity and Pathology.
Lei Qin, Tayab C Waseem, +4 authors, Roza Nurieva.
Front Immunol, 2018 Aug 31; 9. PMID: 30158933    Free PMC article.
A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity.
Prabhakaran Kumar, Palash Bhattacharya, Bellur S Prabhakar.
J Autoimmun, 2018 Sep 04; 95. PMID: 30174217    Free PMC article.
Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.
Lee-Shing Chang, Romualdo Barroso-Sousa, +3 authors, Le Min.
Endocr Rev, 2018 Sep 06; 40(1). PMID: 30184160    Free PMC article.
Serum sCTLA-4 levels and clinical manifestations in ankylosing spondylitis patients.
Sultan Pınar Çetintepe, Taşkın Şentürk, Gökhan Sargın, Neriman Aydın.
Eur J Rheumatol, 2018 Sep 07; 5(2). PMID: 30185360    Free PMC article.
Immune-Related Adverse Events in Cancer Patients Treated With Immune Checkpoint Inhibitors.
Sabina Sandigursky, Adam Mor.
Curr Rheumatol Rep, 2018 Sep 08; 20(10). PMID: 30191417    Free PMC article.
New developments in immunotherapy for lymphoma.
Benjamin Heyman, Yiping Yang.
Cancer Biol Med, 2018 Sep 11; 15(3). PMID: 30197788    Free PMC article.
Importance of Feedback and Feedforward Loops to Adaptive Immune Response Modeling.
Anisur Rahman, Abhinav Tiwari, Jatin Narula, Timothy Hickling.
CPT Pharmacometrics Syst Pharmacol, 2018 Sep 11; 7(10). PMID: 30198637    Free PMC article.
PD-1 has a unique capacity to inhibit allergen-specific human CD4+ T cell responses.
Sandra Rosskopf, Beatrice Jahn-Schmid, +2 authors, Peter Steinberger.
Sci Rep, 2018 Sep 12; 8(1). PMID: 30201974    Free PMC article.
Nivolumab induced encephalopathy in a man with metastatic renal cell cancer: a case report.
Jindřich Kopecký, Ondřej Kubeček, +4 authors, Peter Priester.
J Med Case Rep, 2018 Sep 16; 12(1). PMID: 30217214    Free PMC article.
Characterization of CTLA4 Trafficking and Implications for Its Function.
Sahamoddin Khailaie, Behzad Rowshanravan, +6 authors, Michael Meyer-Hermann.
Biophys J, 2018 Sep 17; 115(7). PMID: 30219287    Free PMC article.
Not All Immune Checkpoints Are Created Equal.
Annika De Sousa Linhares, Judith Leitner, Katharina Grabmeier-Pfistershammer, Peter Steinberger.
Front Immunol, 2018 Sep 21; 9. PMID: 30233564    Free PMC article.
Highly Cited. Review.
On the Road to Immunotherapy-Prospects for Treating Head and Neck Cancers With Checkpoint Inhibitor Antibodies.
Frank J Ward, Lekh N Dahal, Rasha Abu-Eid.
Front Immunol, 2018 Oct 16; 9. PMID: 30319637    Free PMC article.
Immune Checkpoints as Therapeutic Targets in Autoimmunity.
Christopher Paluch, Ana Mafalda Santos, +2 authors, Simon J Davis.
Front Immunol, 2018 Oct 24; 9. PMID: 30349540    Free PMC article.
Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again.
Samantha L Bucktrout, Jeffrey A Bluestone, Fred Ramsdell.
Genome Med, 2018 Nov 01; 10(1). PMID: 30376867    Free PMC article.
Cardiac morbidity in HIV infection is associated with checkpoint inhibitor LAG-3 on CD4 T cells.
Suresh Pallikkuth, Rajendra Pahwa, +9 authors, Savita Pahwa.
PLoS One, 2018 Nov 01; 13(10). PMID: 30379878    Free PMC article.
2018 Nobel Prize in physiology or medicine.
Mark J Smyth, Michele Wl Teng.
Clin Transl Immunology, 2018 Nov 06; 7(10). PMID: 30386598    Free PMC article.
Genomics of response to immune checkpoint therapies for cancer: implications for precision medicine.
Jake R Conway, Eric Kofman, +2 authors, Eliezer Van Allen.
Genome Med, 2018 Dec 01; 10(1). PMID: 30497521    Free PMC article.
The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy.
Arabella Young, Zoe Quandt, Jeffrey A Bluestone.
Cancer Immunol Res, 2018 Dec 05; 6(12). PMID: 30510057    Free PMC article.
CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy.
Monika C Brunner-Weinzierl, Christopher E Rudd.
Front Immunol, 2018 Dec 14; 9. PMID: 30542345    Free PMC article.
pH-sensitive anti-CTLA4 antibodies: yes to efficacy, no to toxicity.
Amnon Altman, Kok-Fai Kong.
Cell Res, 2019 Jul 14; 29(8). PMID: 31300731    Free PMC article.
Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis.
Nina K Serwas, Birgit Hoeger, +39 authors, Kaan Boztug.
Nat Commun, 2019 Jul 17; 10(1). PMID: 31308374    Free PMC article.
Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease.
Dominic P Del Re, Dulguun Amgalan, +2 authors, Richard N Kitsis.
Physiol Rev, 2019 Aug 01; 99(4). PMID: 31364924    Free PMC article.
Sex Differences in Cancer Immunotherapy Efficacy, Biomarkers, and Therapeutic Strategy.
Shixiang Wang, Li An Cowley, Xue-Song Liu.
Molecules, 2019 Sep 07; 24(18). PMID: 31487832    Free PMC article.
Highly Cited. Review.
β cell responses to inflammation.
Sahar Usmani-Brown, Ana Luisa Perdigoto, +5 authors, Kevan C Herold.
Mol Metab, 2019 Sep 11; 27S. PMID: 31500821    Free PMC article.
Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases.
Blagoje Soskic, Eddie Cano-Gamez, +9 authors, Gosia Trynka.
Nat Genet, 2019 Sep 25; 51(10). PMID: 31548716    Free PMC article.
Monoclonal Antibodies in Dermatooncology-State of the Art and Future Perspectives.
Malgorzata Bobrowicz, Radoslaw Zagozdzon, +3 authors, Magdalena Winiarska.
Cancers (Basel), 2019 Sep 27; 11(10). PMID: 31554169    Free PMC article.
The impact of CTLA-4 blockade and interferon-α on clonality of T-cell repertoire in the tumor microenvironment and peripheral blood of metastatic melanoma patients.
Arjun Khunger, Julie A Rytlewski, +2 authors, Ahmad A Tarhini.
Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646098    Free PMC article.
Immune and Inflammatory Cells of the Tumor Microenvironment Represent Novel Therapeutic Targets in Classical Hodgkin Lymphoma.
Eleonora Calabretta, Francesco d'Amore, Carmelo Carlo-Stella.
Int J Mol Sci, 2019 Nov 07; 20(21). PMID: 31694167    Free PMC article.
Immune Checkpoint Inhibition in Hodgkin Lymphoma.
Ryan H Moy, Anas Younes.
Hemasphere, 2018 Feb 16; 2(1). PMID: 31723749    Free PMC article.
Analysis of key clinical features for achieving complete remission in stage III and IV non-small cell lung cancer patients.
Takuya Aoki, Takeshi Akiba, +21 authors, Koichiro Asano.
Respir Res, 2019 Nov 23; 20(1). PMID: 31752884    Free PMC article.
Blocking TGF-β Signaling To Enhance The Efficacy Of Immune Checkpoint Inhibitor.
Xianguang Bai, Ming Yi, +2 authors, Kongming Wu.
Onco Targets Ther, 2019 Dec 07; 12. PMID: 31807028    Free PMC article.
Mechanisms of immune-related adverse events during the treatment of cancer with immune checkpoint inhibitors.
Sophia C Weinmann, David S Pisetsky.
Rheumatology (Oxford), 2019 Dec 10; 58(Suppl 7). PMID: 31816080    Free PMC article.
Harnessing NK Cells for Cancer Treatment.
Paola Minetto, Fabio Guolo, +7 authors, Emanuela Marcenaro.
Front Immunol, 2019 Dec 24; 10. PMID: 31867006    Free PMC article.
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways.
Yunlong Zhao, Calvin K Lee, +8 authors, Enfu Hui.
Immunity, 2019 Nov 24; 51(6). PMID: 31757674    Free PMC article.
Neurological Immune Related Adverse Events Associated with Nivolumab, Ipilimumab, and Pembrolizumab Therapy-Review of the Literature and Future Outlook.
Nora Möhn, Gernot Beutel, +3 authors, Thomas Skripuletz.
J Clin Med, 2019 Oct 28; 8(11). PMID: 31653079    Free PMC article.
Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy.
Yan Zhang, Xuexiang Du, +9 authors, Yang Liu.
Cell Res, 2019 Jul 04; 29(8). PMID: 31267017    Free PMC article.
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.
Florian Wiede, Kun-Hui Lu, +16 authors, Tony Tiganis.
EMBO J, 2019 Dec 06; 39(2). PMID: 31803974    Free PMC article.
Odds ratio of programmed cell death-1 or ligand 1 inhibitor-related endocrine dysfunction in patients with lung cancer: A systematic review and meta-analysis.
Jian Xie, Zewen Zhang, +4 authors, Yuan Tian.
Medicine (Baltimore), 2019 Dec 20; 98(50). PMID: 31852114    Free PMC article.
Systematic Review.
Autoimmunity, checkpoint inhibitor therapy and immune-related adverse events: A review.
Shaheen Khan, David E Gerber.
Semin Cancer Biol, 2019 Jul 23; 64. PMID: 31330185    Free PMC article.
Fast and fierce versus slow and smooth: Heterogeneity in immune responses to Plasmodium in the controlled human malaria infection model.
Xi Zen Yap, Matthew B B McCall, Robert W Sauerwein.
Immunol Rev, 2019 Oct 13; 293(1). PMID: 31605396    Free PMC article.
Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance.
Tijana Martinov, Brian T Fife.
Ann N Y Acad Sci, 2019 Apr 27; 1461(1). PMID: 31025378    Free PMC article.
Recalling the Biological Significance of Immune Checkpoints on NK Cells: A Chance to Overcome LAG3, PD1, and CTLA4 Inhibitory Pathways by Adoptive NK Cell Transfer?
Pilar M Lanuza, Cecilia Pesini, +3 authors, Julian Pardo.
Front Immunol, 2020 Jan 31; 10. PMID: 31998304    Free PMC article.
The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer.
Isabel Alvarado-Cruz, Rithy Meas, +3 authors, Joann Balazs Sweasy.
Mutagenesis, 2019 Dec 28; 35(1). PMID: 31880305    Free PMC article.
Structure and Optimization of Checkpoint Inhibitors.
Sarah L Picardo, Jeffrey Doi, Aaron R Hansen.
Cancers (Basel), 2019 Dec 28; 12(1). PMID: 31877721    Free PMC article.
Immune checkpoint inhibitor-induced inflammatory arthritis as a model of autoimmune arthritis.
Laura C Cappelli, Mekha A Thomas, +2 authors, Erika Darrah.
Immunol Rev, 2020 Jan 14; 294(1). PMID: 31930524    Free PMC article.
Immune checkpoint modulation enhances HIV-1 antibody induction.
Todd Bradley, Masayuki Kuraoka, +27 authors, Barton F Haynes.
Nat Commun, 2020 Feb 23; 11(1). PMID: 32075963    Free PMC article.
Insights Into Lung Cancer Immune-Based Biology, Prevention, and Treatment.
Sara Saab, Hussein Zalzale, +3 authors, Humam Kadara.
Front Immunol, 2020 Mar 03; 11. PMID: 32117295    Free PMC article.
NK Cell-Based Immune Checkpoint Inhibition.
Muhammad Khan, Sumbal Arooj, Hua Wang.
Front Immunol, 2020 Mar 03; 11. PMID: 32117298    Free PMC article.
Impact of selective CD28 blockade on virus-specific immunity to a murine Epstein-Barr virus homolog.
Rebecca L Crepeau, Joseph A Elengickal, Glenn M La Muraglia, Mandy L Ford.
Am J Transplant, 2019 Feb 26; 19(8). PMID: 30801917    Free PMC article.
RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4.
Takashi Sekiya, Satoshi Takaki.
Sci Rep, 2019 May 08; 9(1). PMID: 31061392    Free PMC article.
Engineered Dendritic Cell-Directed Concurrent Activation of Multiple T cell Inhibitory Pathways Induces Robust Immune Tolerance.
Radhika R Gudi, Subha Karumuthil-Melethil, +2 authors, Chenthamarakshan Vasu.
Sci Rep, 2019 Aug 21; 9(1). PMID: 31427630    Free PMC article.
CTLA-4: a moving target in immunotherapy.
Behzad Rowshanravan, Neil Halliday, David M Sansom.
Blood, 2017 Nov 10; 131(1). PMID: 29118008    Free PMC article.
Highly Cited. Review.
The challenges of checkpoint inhibition in the treatment of multiple myeloma.
Barry Paul, Shuqi Kang, Zhihong Zheng, Yubin Kang.
Cell Immunol, 2018 Oct 22; 334. PMID: 30342750    Free PMC article.
Myocardial Inflammation, Measured Using 18-Fluorodeoxyglucose Positron Emission Tomography With Computed Tomography, Is Associated With Disease Activity in Rheumatoid Arthritis.
Isabelle Amigues, Aylin Tugcu, +7 authors, Joan M Bathon.
Arthritis Rheumatol, 2018 Nov 09; 71(4). PMID: 30407745    Free PMC article.
Immune Checkpoint Inhibitors and the Risk of Allograft Rejection: A Comprehensive Analysis on an Emerging Issue.
Luis E Aguirre, Maria E Guzman, Gilberto Lopes, Judith Hurley.
Oncologist, 2018 Nov 11; 24(3). PMID: 30413665    Free PMC article.
Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity.
Chien-Chun Steven Pai, Donald M Simons, +22 authors, Lawrence Fong.
J Clin Invest, 2018 Dec 12; 129(1). PMID: 30530991    Free PMC article.
Recent updates in cancer immunotherapy: a comprehensive review and perspective of the 2018 China Cancer Immunotherapy Workshop in Beijing.
Zihai Li, Wenru Song, Mark Rubinstein, Delong Liu.
J Hematol Oncol, 2018 Dec 24; 11(1). PMID: 30577797    Free PMC article.
Highly Cited. Review.
Targeting Costimulatory Pathways in Systemic Sclerosis.
Gonçalo Boleto, Yannick Allanore, Jérôme Avouac.
Front Immunol, 2019 Jan 09; 9. PMID: 30619351    Free PMC article.
Reprogramming responsiveness to checkpoint blockade in dysfunctional CD8 T cells.
Christine E Nelson, Lauren J Mills, +6 authors, Vaiva Vezys.
Proc Natl Acad Sci U S A, 2019 Jan 27; 116(7). PMID: 30679280    Free PMC article.
Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance.
Simon Glatigny, Barbara Höllbacher, +13 authors, Estelle Bettelli.
J Immunol, 2019 Jan 27; 202(5). PMID: 30683697    Free PMC article.
Cardiovascular toxicities associated with immune checkpoint inhibitors.
Jiun-Ruey Hu, Roberta Florido, +7 authors, Javid Moslehi.
Cardiovasc Res, 2019 Feb 05; 115(5). PMID: 30715219    Free PMC article.
Highly Cited. Review.
Association and gene-gene interaction analyses for polymorphic variants in CTLA-4 and FOXP3 genes: role in susceptibility to autoimmune thyroid disease.
Nusrath Fathima, Parimala Narne, Mohammed Ishaq.
Endocrine, 2019 Feb 17; 64(3). PMID: 30771152
Repurposing Drugs for Cancer Radiotherapy: Early Successes and Emerging Opportunities.
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Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity.
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Trends Mol Med, 2019 Mar 23; 25(5). PMID: 30898473    Free PMC article.
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PLoS One, 2019 May 22; 14(5). PMID: 31112568    Free PMC article.
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Germline Features Associated with Immune Infiltration in Solid Tumors.
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Arthritis Res Ther, 2020 Apr 02; 22(1). PMID: 32228715    Free PMC article.
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MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner.
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Immunotherapy of Cancer: Developments and Reference Points, an Unorthodox Approach.
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A Phase I Study of the Combination of Rituximab and Ipilimumab in Patients with Relapsed/Refractory B-Cell Lymphoma.
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Immune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer Therapy.
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Dan You, Stephen Hillerman, +27 authors, Jinqi Liu.
J Immunother Cancer, 2021 Jan 08; 9(1). PMID: 33408094    Free PMC article.
CTLA-4 expression by B-1a B cells is essential for immune tolerance.
Yang Yang, Xiao Li, +19 authors, Leonore A Herzenberg.
Nat Commun, 2021 Jan 24; 12(1). PMID: 33483505    Free PMC article.
Immunotherapy-Associated Cardiotoxicity of Immune Checkpoint Inhibitors and Chimeric Antigen Receptor T Cell Therapy: Diagnostic and Management Challenges and Strategies.
Ashley F Stein-Merlob, Michael V Rothberg, Patrick Holman, Eric H Yang.
Curr Cardiol Rep, 2021 Jan 24; 23(3). PMID: 33483873    Free PMC article.
CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis.
Blagoje Soskic, Louisa E Jeffery, +8 authors, David M Sansom.
Front Immunol, 2021 Jan 26; 11. PMID: 33488578    Free PMC article.
Rethinking immune checkpoint blockade: 'Beyond the T cell'.
Xiuting Liu, Graham D Hogg, David G DeNardo.
J Immunother Cancer, 2021 Jan 21; 9(1). PMID: 33468555    Free PMC article.
Understanding and Targeting Human Cancer Regulatory T Cells to Improve Therapy.
H Ryan Kolb, Nicholas Borcherding, Weizhou Zhang.
Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523451
Lysophosphatidic Acid Is an Inflammatory Lipid Exploited by Cancers for Immune Evasion via Mechanisms Similar and Distinct From CTLA-4 and PD-1.
Divij Mathew, Raul M Torres.
Front Immunol, 2021 Feb 16; 11. PMID: 33584637    Free PMC article.
Decoding Melanoma Development and Progression: Identification of Therapeutic Vulnerabilities.
Kevinn Eddy, Raj Shah, Suzie Chen.
Front Oncol, 2021 Feb 23; 10. PMID: 33614507    Free PMC article.
PD-L1 and B7-1 Cis-Interaction: New Mechanisms in Immune Checkpoints and Immunotherapies.
Christopher D Nishimura, Marc C Pulanco, +2 authors, Xingxing Zang.
Trends Mol Med, 2020 Nov 18; 27(3). PMID: 33199209    Free PMC article.
Immune checkpoint inhibitor-associated myocarditis: manifestations and mechanisms.
Javid Moslehi, Andrew H Lichtman, +2 authors, Richard N Kitsis.
J Clin Invest, 2021 Mar 02; 131(5). PMID: 33645548    Free PMC article.
Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis.
James A Hutchinson, Katharina Kronenberg, +21 authors, Sebastian Haferkamp.
Nat Commun, 2021 Mar 06; 12(1). PMID: 33664251    Free PMC article.
The Efficacy and Safety of Immune Checkpoint Inhibitors in Patients With Cancer and Preexisting Autoimmune Disease.
Hui Tang, Jianfeng Zhou, Chunmei Bai.
Front Oncol, 2021 Mar 12; 11. PMID: 33692958    Free PMC article.
Renal toxicity of targeted therapies for renal cell carcinoma in patients with normal and impaired kidney function.
Łukasz Mielczarek, Anna Brodziak, +3 authors, Anna M Czarnecka.
Cancer Chemother Pharmacol, 2021 Mar 27; 87(6). PMID: 33768301    Free PMC article.
Unraveling the Role of Immune Checkpoints in Leishmaniasis.
Rafael de Freitas E Silva, Esther von Stebut.
Front Immunol, 2021 Mar 30; 12. PMID: 33776999    Free PMC article.
The Multifaceted Role of Th1, Th9, and Th17 Cells in Immune Checkpoint Inhibition Therapy.
Jongdae Lee, Beatriz Lozano-Ruiz, +3 authors, Jose M González-Navajas.
Front Immunol, 2021 Mar 30; 12. PMID: 33777008    Free PMC article.
Novel human immunomodulatory T cell receptors and their double-edged potential in autoimmunity, cardiovascular disease and cancer.
Pilar Martín, Rafael Blanco-Domínguez, Raquel Sánchez-Díaz.
Cell Mol Immunol, 2020 Nov 26; 18(4). PMID: 33235388    Free PMC article.
Cellular and molecular mechanisms breaking immune tolerance in inborn errors of immunity.
Georgios Sogkas, Faranaz Atschekzei, +3 authors, Reinhold Ernst Schmidt.
Cell Mol Immunol, 2021 Apr 03; 18(5). PMID: 33795850    Free PMC article.
Advanced Nanotechnology for Enhancing Immune Checkpoint Blockade Therapy.
Chiara Cremolini, Emanuela Vitale, Raffaella Rastaldo, Claudia Giachino.
Nanomaterials (Basel), 2021 Apr 04; 11(3). PMID: 33800368    Free PMC article.
CTLA-4 in Regulatory T Cells for Cancer Immunotherapy.
Navid Sobhani, Dana Rae Tardiel-Cyril, +3 authors, Yong Li.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33809974    Free PMC article.
A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Spencer C Wei, Wouter C Meijers, +24 authors, James P Allison.
Cancer Discov, 2020 Dec 02; 11(3). PMID: 33257470    Free PMC article.
A snapshot of the PD-1/PD-L1 pathway.
Chinmoy Ghosh, Gary Luong, Yue Sun.
J Cancer, 2021 Apr 16; 12(9). PMID: 33854633    Free PMC article.
Metabolic barriers to cancer immunotherapy.
Kristin DePeaux, Greg M Delgoffe.
Nat Rev Immunol, 2021 May 01; 21(12). PMID: 33927375    Free PMC article.
Immunotherapy for Prostate Cancer.
Nicholas J Venturini, Charles G Drake.
Cold Spring Harb Perspect Med, 2018 Sep 12; 9(5). PMID: 30201787    Free PMC article.
Checkpoint Inhibitor-Induced Colitis-A Clinical Overview of Incidence, Prognostic Implications and Extension of Current Treatment Options.
Carmen Portenkirchner, Peter Kienle, Karoline Horisberger.
Pharmaceuticals (Basel), 2021 May 01; 14(4). PMID: 33923423    Free PMC article.
Immune Checkpoint Inhibitors: New Weapons Against Medullary Thyroid Cancer?
Sergio Di Molfetta, Andrea Dotto, +4 authors, Antongiulio Faggiano.
Front Endocrinol (Lausanne), 2021 May 04; 12. PMID: 33935977    Free PMC article.
Mesencephalic astrocyte-derived neurotrophic factor is secreted from interferon-γ-activated tumor cells through ER calcium depletion.
Michael Peled, Tali H Bar-Lev, +7 authors, Amir Onn.
PLoS One, 2021 Apr 24; 16(4). PMID: 33891607    Free PMC article.
Soluble immune checkpoint molecules: Serum markers for cancer diagnosis and prognosis.
Rituparna Chakrabarti, Bhavya Kapse, Gayatri Mukherjee.
Cancer Rep (Hoboken), 2020 Jul 29; 2(4). PMID: 32721130    Free PMC article.
Immune Checkpoints, a Novel Class of Therapeutic Targets for Autoimmune Diseases.
Yujia Zhai, Reza Moosavi, Mingnan Chen.
Front Immunol, 2021 May 11; 12. PMID: 33968036    Free PMC article.
Regulation of mRNA stability by RBPs and noncoding RNAs contributing to the pathogenicity of Th17 cells.
Yiwei Zhang, Zhiyuan Wei, +6 authors, Yi Tian.
RNA Biol, 2020 Dec 12; 18(5). PMID: 33302787    Free PMC article.
Development of a mechanism of action-reflective, dual target cell-based reporter bioassay for a bispecific monoclonal antibody targeting human CTLA-4 and PD-1.
Weimin Chen, Madhu Pandey, +7 authors, Shihua Lin.
MAbs, 2021 Apr 20; 13(1). PMID: 33870864    Free PMC article.
Mechanisms and Management of Immune Checkpoint Inhibitor-Related Cardiac Adverse Events.
Hiroshi Kadowaki, Hiroshi Akazawa, Junichi Ishida, Issei Komuro.
JMA J, 2021 May 18; 4(2). PMID: 33997442    Free PMC article.
Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells.
Nadia Bannoud, Tomás Dalotto-Moreno, +5 authors, Diego O Croci.
Front Immunol, 2021 May 25; 12. PMID: 34025660    Free PMC article.
Mechanisms of Cardiovascular Toxicities Associated With Immunotherapies.
Alan H Baik, Olalekan O Oluwole, +4 authors, Javid J Moslehi.
Circ Res, 2021 May 04; 128(11). PMID: 33934609    Free PMC article.
Stay on Target: Reengaging Cancer Vaccines in Combination Immunotherapy.
Benjamin Wolfson, S Elizabeth Franks, James W Hodge.
Vaccines (Basel), 2021 Jun 03; 9(5). PMID: 34063388    Free PMC article.
Spontaneous and Immune Checkpoint Inhibitor-Induced Autoimmune Diseases: Analysis of Temporal Information by Using the Japanese Adverse Drug Event Report Database.
Keiko Ogawa, Yoshihiro Kozuka, +3 authors, Rumiko Hosoki.
Clin Drug Investig, 2021 Jun 11; 41(7). PMID: 34110613
Rheumatic Immune-Related Adverse Events-A Consequence of Immune Checkpoint Inhibitor Therapy.
Anca Bobircă, Florin Bobircă, +6 authors, Anca Emanuela Mușetescu.
Biology (Basel), 2021 Jul 03; 10(6). PMID: 34203101    Free PMC article.
Cardiac Toxicities Associated with Immune Checkpoints Inhibitors: Mechanisms, Manifestations and Management.
Abdulrazzak Zarifa, Jin Wan Kim, +3 authors, Peter Y Kim.
Korean Circ J, 2021 Jul 07; 51(7). PMID: 34227272    Free PMC article.
Myocarditis Induced by Immune Checkpoint Inhibitors: Mechanisms and Therapeutic Prospects.
Wenlu Zou, Jie Lu, Yan Hao.
J Inflamm Res, 2021 Jul 17; 14. PMID: 34267536    Free PMC article.
The Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy.
Bonnie L Russell, Selisha A Sooklal, +2 authors, Monde Ntwasa.
Front Oncol, 2021 Jul 17; 11. PMID: 34268109    Free PMC article.
Pulsed focused ultrasound can improve the anti-cancer effects of immune checkpoint inhibitors in murine pancreatic cancer.
Petros X E Mouratidis, Marcia Costa, +2 authors, Gail Ter Haar.
J R Soc Interface, 2021 Jul 08; 18(180). PMID: 34229458    Free PMC article.
DCision-making in tumors governs T cell anti-tumor immunity.
Francesca Alfei, Ping-Chih Ho, Wan-Lin Lo.
Oncogene, 2021 Jul 23; 40(34). PMID: 34290401    Free PMC article.
Current cancer therapies and their influence on glucose control.
Carly Yim, Kerry Mansell, Nassrein Hussein, Terra Arnason.
World J Diabetes, 2021 Jul 31; 12(7). PMID: 34326951    Free PMC article.
Molecular Mechanisms of Resistance to Immune Checkpoint Inhibitors in Melanoma Treatment: An Update.
Sonja Vukadin, Farah Khaznadar, +2 authors, Martina Smolic.
Biomedicines, 2021 Aug 07; 9(7). PMID: 34356899    Free PMC article.
Regulation of CTLA-4 recycling by LRBA and Rab11.
Daniel Janman, Claudia Hinze, +8 authors, David M Sansom.
Immunology, 2021 May 08; 164(1). PMID: 33960403    Free PMC article.
Immune Checkpoint Inhibitor Therapy Aggravates T Cell-Driven Plaque Inflammation in Atherosclerosis.
Kikkie Poels, Mandy M T van Leent, +17 authors, Esther Lutgens.
JACC CardioOncol, 2021 Aug 17; 2(4). PMID: 34396271    Free PMC article.
Cryptic association of B7-2 molecules and its implication for clustering.
Swetha Lankipalli, Mahadeva Swamy H S, +3 authors, Udupi A Ramagopal.
Protein Sci, 2021 Jul 01; 30(9). PMID: 34191384    Free PMC article.
Immune Checkpoint Inhibitors Mediated Lymphocytic and Giant Cell Myocarditis: Uncovering Etiological Mechanisms.
Rishi Rikhi, Jaret Karnuta, +5 authors, Rohit Moudgil.
Front Cardiovasc Med, 2021 Aug 27; 8. PMID: 34434981    Free PMC article.
The role of immunogenic cell death in gastrointestinal cancer immunotherapy (Review).
Worawat Songjang, Chatchai Nensat, Sutatip Pongcharoen, Arunya Jiraviriyakul.
Biomed Rep, 2021 Sep 14; 15(4). PMID: 34512974    Free PMC article.
Effect of Cellular-Based Artificial Antigen Presenting Cells Expressing ICOSL, in T-cell Subtypes Differentiation and Activation.
Mehdi Talebi, Hojjatollah Nozad Charoudeh, +2 authors, Tohid Kazemi.
Adv Pharm Bull, 2021 Sep 14; 11(3). PMID: 34513629    Free PMC article.
A CTLA-4 blocking strategy based on Nanoboby in dendritic cell-stimulated cytokine-induced killer cells enhances their anti-tumor effects.
Wu Wang, Xi Wang, +7 authors, Xiaoling Lu.
BMC Cancer, 2021 Sep 17; 21(1). PMID: 34525966    Free PMC article.
Development of preclinical and clinical models for immune-related adverse events following checkpoint immunotherapy: a perspective from SITC and AACR.
Nicholas L Bayless, Jeffrey A Bluestone, +8 authors, Theresa L Walunas.
J Immunother Cancer, 2021 Sep 05; 9(9). PMID: 34479924    Free PMC article.
The Status of Adjuvant and Neoadjuvant Melanoma Therapy, New Developments and Upcoming Challenges.
Henner Stege, Maximilian Haist, +5 authors, Stephan Grabbe.
Target Oncol, 2021 Sep 24; 16(5). PMID: 34554353    Free PMC article.
Development of poly(ADP-ribose) polymerase inhibitor and immunotherapy combinations: progress, pitfalls, and promises.
Melissa M Pham, Natalie Y L Ngoi, +2 authors, Timothy A Yap.
Trends Cancer, 2021 Jun 24; 7(10). PMID: 34158277    Free PMC article.
Epitranscriptomic Approach: To Improve the Efficacy of ICB Therapy by Co-Targeting Intracellular Checkpoint CISH.
Sunil Kumar, Parth Sarthi, +4 authors, Yong-Soo Bae.
Cells, 2021 Sep 29; 10(9). PMID: 34571899    Free PMC article.
Targeting TIGIT for Immunotherapy of Cancer: Update on Clinical Development.
Anand Rotte, Srikumar Sahasranaman, Nageshwar Budha.
Biomedicines, 2021 Sep 29; 9(9). PMID: 34572463    Free PMC article.
Inhibiting the Unconventionals: Importance of Immune Checkpoint Receptors in γδ T, MAIT, and NKT Cells.
Elisa Catafal-Tardos, Maria Virginia Baglioni, Vasileios Bekiaris.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572874    Free PMC article.
Targeting the spectrum of immune checkpoints in prostate cancer.
Laura A Sena, Samuel R Denmeade, Emmanuel S Antonarakis.
Expert Rev Clin Pharmacol, 2021 Jul 16; 14(10). PMID: 34263692    Free PMC article.
Immune checkpoints and immunotherapy in non-small cell lung cancer: Novel study progression, challenges and solutions.
Lin-Rui Ma, Jia-Xin Li, +5 authors, Pei-Yu Yan.
Oncol Lett, 2021 Oct 02; 22(5). PMID: 34594428    Free PMC article.
Leveraging the Treg-intrinsic CTLA4-PKCη signaling pathway for cancer immunotherapy.
Hsin-Yu Liu, Christophe Pedros, +3 authors, Amnon Altman.
J Immunother Cancer, 2021 Oct 01; 9(9). PMID: 34588224    Free PMC article.
Immune checkpoint deficiencies and autoimmune lymphoproliferative syndromes.
Laura Gámez-Díaz, Bodo Grimbacher.
Biomed J, 2021 Aug 14; 44(4). PMID: 34384744    Free PMC article.
Clinical Characteristics and Outcomes in Immune Checkpoint Inhibitor Therapy-Associated Myocarditis.
Ravi A Thakker, Marissa A Lee, +9 authors, Khaled F Chatila.
Cardiol Res, 2021 Oct 26; 12(5). PMID: 34691324    Free PMC article.
Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation.
Imtiaz Iftakhar-E-Khuda, Alberto Pessia, +11 authors, Sirpa Jalkanen.
Cell Mol Life Sci, 2021 Nov 02; 78(23). PMID: 34719737    Free PMC article.
Cytotoxic T lymphocyte antigen-4 regulates development of xenogenic graft versus host disease in mice via modulation of host immune responses induced by changes in human T cell engraftment and gene expression.
Chunxu Gao, Debra Gardner, +7 authors, Ravi Malaviya.
Clin Exp Immunol, 2021 Sep 07; 206(3). PMID: 34487545    Free PMC article.
Checkpoint Inhibitors in Melanoma Patients with Underlying Autoimmune Disease.
Hilary Dietz, Sophia C Weinmann, April K Salama.
Cancer Manag Res, 2021 Nov 11; 13. PMID: 34754240    Free PMC article.
Expression of immune checkpoint regulators, cytotoxic T lymphocyte antigen 4 (CTLA-4), and CD137 in cervical carcinoma.
Ari Kassardjian, Neda A Moatamed.
Int J Clin Exp Pathol, 2021 Nov 12; 14(10). PMID: 34760040    Free PMC article.
New insights into exosome mediated tumor-immune escape: Clinical perspectives and therapeutic strategies.
Anup S Pathania, Philip Prathipati, Kishore B Challagundla.
Biochim Biophys Acta Rev Cancer, 2021 Sep 07; 1876(2). PMID: 34487817    Free PMC article.
The immunotherapeutic role of indoleamine 2,3-dioxygenase in head and neck squamous cell carcinoma: A systematic review.
Daniel J Lin, James C K Ng, +4 authors, Andrew L Mellor.
Clin Otolaryngol, 2021 May 31; 46(5). PMID: 34053179    Free PMC article.
Systematic Review.
Immune Checkpoints and Innate Lymphoid Cells-New Avenues for Cancer Immunotherapy.
Nicolas Jacquelot, Maryam Ghaedi, +3 authors, Pamela S Ohashi.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885076    Free PMC article.
Neoantigen-Reactive T Cells: The Driving Force behind Successful Melanoma Immunotherapy.
Lindy Davis, Ashley Tarduno, Yong-Chen Lu.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885172    Free PMC article.
The foundations of immune checkpoint blockade and the ipilimumab approval decennial.
Alan J Korman, Sarah C Garrett-Thomson, Nils Lonberg.
Nat Rev Drug Discov, 2021 Dec 24;. PMID: 34937915
Pathogenesis of Autoimmune Hepatitis-Cellular and Molecular Mechanisms.
Claudia Sirbe, Gelu Simu, +2 authors, Tudor Lucian Pop.
Int J Mol Sci, 2021 Dec 25; 22(24). PMID: 34948375    Free PMC article.
Immune Checkpoint Inhibitor (ICI)-Related Cardiotoxicity.
Abdulrazzak Zarifa, Juan Lopez-Mattei, +3 authors, Peter Y Kim.
Adv Exp Med Biol, 2022 Jan 02; 1342. PMID: 34972975
Pulmonary Toxicities of Immunotherapy.
Mehmet Altan, Linda Zhong, Vickie R Shannon, Ajay Sheshadri.
Adv Exp Med Biol, 2022 Jan 02; 1342. PMID: 34972974
Renal Toxicity.
Maen Abdelrahim, Ala Abudayyeh.
Adv Exp Med Biol, 2022 Jan 02; 1342. PMID: 34972976
Immunotherapy Resistance in Glioblastoma.
Elaina J Wang, Jia-Shu Chen, +5 authors, Manish K Aghi.
Front Genet, 2022 Jan 04; 12. PMID: 34976006    Free PMC article.
Immune Checkpoint Inhibitor-Associated Colitis: From Mechanism to Management.
Liansha Tang, Jialing Wang, +4 authors, Xuelei Ma.
Front Immunol, 2022 Jan 08; 12. PMID: 34992611    Free PMC article.
Mice transgenic for human CTLA4-CD28 fusion gene show proliferation and transformation of ATLL-like and AITL-like T cells.
Gyu Jin Lee, Yukyung Jun, +3 authors, Jaesang Kim.
Oncoimmunology, 2022 Jan 11; 11(1). PMID: 35003894    Free PMC article.
Real-world cardiovascular toxicity of immune checkpoint inhibitors in cancer patients: a retrospective controlled cohort study.
Chuan Zhang, Zhulu Chen, +4 authors, Zhong Zuo.
Am J Cancer Res, 2022 Jan 13; 11(12). PMID: 35018243    Free PMC article.
A Promising Treatment Strategy for Lung Cancer: A Combination of Radiotherapy and Immunotherapy.
Yuhei Miyasaka, Hiro Sato, +3 authors, Tatsuya Ohno.
Cancers (Basel), 2022 Jan 12; 14(1). PMID: 35008367    Free PMC article.
Mechanisms of immune checkpoint inhibitor-mediated liver injury.
Layla Shojaie, Myra Ali, Andrea Iorga, Lily Dara.
Acta Pharm Sin B, 2022 Jan 14; 11(12). PMID: 35024302    Free PMC article.
Heart Failure With Targeted Cancer Therapies: Mechanisms and Cardioprotection.
Virginia S Hahn, Kathleen W Zhang, +3 authors, Bonnie Ky.
Circ Res, 2021 May 14; 128(10). PMID: 33983833    Free PMC article.
T-cell-receptor cross-recognition and strategies to select safe T-cell receptors for clinical translation.
Amalie Kai Bentzen, Sine Reker Hadrup.
Immunooncol Technol, 2019 Sep 01; 2. PMID: 35036898    Free PMC article.
Hallmarks of response, resistance, and toxicity to immune checkpoint blockade.
Golnaz Morad, Beth A Helmink, Padmanee Sharma, Jennifer A Wargo.
Cell, 2021 Oct 09; 184(21). PMID: 34624224    Free PMC article.
Immune-checkpoint inhibitors: long-term implications of toxicity.
Douglas B Johnson, Caroline A Nebhan, Javid J Moslehi, Justin M Balko.
Nat Rev Clin Oncol, 2022 Jan 28; 19(4). PMID: 35082367    Free PMC article.
Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject 'cold' tumors.
Monika Semmrich, Jean-Baptiste Marchand, +15 authors, Björn Frendéus.
J Immunother Cancer, 2022 Jan 22; 10(1). PMID: 35058324    Free PMC article.
Monoclonal Antibodies to CTLA-4 with Focus on Ipilimumab.
Grazia Graziani, Lucia Lisi, Lucio Tentori, Pierluigi Navarra.
Exp Suppl, 2022 Feb 16; 113. PMID: 35165868
Inborn Errors of Immunity and Their Phenocopies: CTLA4 and PD-1.
Yuwei Hao, Matthew C Cook.
Front Immunol, 2022 Feb 15; 12. PMID: 35154081    Free PMC article.
Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?
Tsvetana Petrova, Kyle Bennett, +4 authors, Philip Cohen.
PLoS One, 2022 Feb 15; 17(2). PMID: 35157702    Free PMC article.
Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling.
Sayaka Ishihara, Tsuyoshi Sato, +5 authors, Koko Katagiri.
Commun Biol, 2022 Mar 06; 5(1). PMID: 35246619    Free PMC article.
RAS pathway regulation in melanoma.
Amira Al Mahi, Julien Ablain.
Dis Model Mech, 2022 Mar 03; 15(2). PMID: 35234863    Free PMC article.
A radiologist's guide to novel anticancer therapies in the era of precision medicine.
Ali Khader, Rozan Bokhari, +4 authors, Richard Thomas.
Eur J Radiol Open, 2022 Mar 11; 9. PMID: 35265736    Free PMC article.
Seven mysteries of LAG-3: a multi-faceted immune receptor of increasing complexity.
Stephanie E A Burnell, Lorenzo Capitani, +3 authors, Andrew Godkin.
Immunother Adv, 2022 Mar 11; 2(1). PMID: 35265944    Free PMC article.
The link between circulating follicular helper T cells and autoimmunity.
Lucy S K Walker.
Nat Rev Immunol, 2022 Mar 13;. PMID: 35277664    Free PMC article.
Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors.
Alan H Baik, Katy K Tsai, David Y Oh, Mandar A Aras.
Clin Sci (Lond), 2021 Mar 10; 135(5). PMID: 33686402    Free PMC article.
Improvement of the anticancer efficacy of PD-1/PD-L1 blockade via combination therapy and PD-L1 regulation.
Mengling Wu, Qianrui Huang, +4 authors, Yong Xia.
J Hematol Oncol, 2022 Mar 14; 15(1). PMID: 35279217    Free PMC article.
The Immunogenetics of Alopecia areata.
Fateme Rajabi, Fahimeh Abdollahimajd, +2 authors, Alireza Firooz.
Adv Exp Med Biol, 2022 Mar 15; 1367. PMID: 35286691
Immunogenetics of Lupus Erythematosus.
Begüm Ünlü, Ümit Türsen, +2 authors, Fateme Rajabi.
Adv Exp Med Biol, 2022 Mar 15; 1367. PMID: 35286698
Immune Checkpoint Inhibitors in 10 Years: Contribution of Basic Research and Clinical Application in Cancer Immunotherapy.
Jii Bum Lee, Hye Ryun Kim, Sang-Jun Ha.
Immune Netw, 2022 Mar 17; 22(1). PMID: 35291660    Free PMC article.
Checkpoint Inhibitors and Induction of Celiac Disease-like Condition.
Aaron Lerner, Carina Benzvi.
Biomedicines, 2022 Mar 26; 10(3). PMID: 35327411    Free PMC article.
The Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers.
Alison Felipe Bordini Biggi, Deilson Elgui de Oliveira.
Biomolecules, 2022 Mar 26; 12(3). PMID: 35327589    Free PMC article.
T Cell Homeostatic Proliferation Promotes a Redox State That Drives Metabolic and Epigenetic Upregulation of Inflammatory Pathways in Lupus.
Ralph C Budd, Christopher D Scharer, +2 authors, Karen A Fortner.
Antioxid Redox Signal, 2021 Jul 31; 36(7-9). PMID: 34328790    Free PMC article.
Immunomodulatory Properties of Immune Checkpoint Inhibitors-More than Boosting T-Cell Responses?
Michael Kuske, Maximilian Haist, +2 authors, Matthias Bros.
Cancers (Basel), 2022 Apr 13; 14(7). PMID: 35406483    Free PMC article.
Tipping the balance: inhibitory checkpoints in intestinal homeostasis.
Maria E Joosse, Iris Nederlof, Lucy S K Walker, Janneke N Samsom.
Mucosal Immunol, 2018 Dec 01; 12(1). PMID: 30498201
The cure from within? a review of the microbiome and diet in melanoma.
Priyanka Kumar, Danielle Brazel, +5 authors, Justin T Moyers.
Cancer Metastasis Rev, 2022 Apr 28;. PMID: 35474500    Free PMC article.
Immune checkpoint inhibitors for the treatment of melanoma.
Francesco Sabbatino, Luigi Liguori, Stefano Pepe, Soldano Ferrone.
Expert Opin Biol Ther, 2022 Feb 09; 22(5). PMID: 35130816    Free PMC article.
Exploring the Mechanisms Underlying the Cardiotoxic Effects of Immune Checkpoint Inhibitor Therapies.
Daniel Ronen, Aseel Bsoul, +4 authors, Rabea Asleh.
Vaccines (Basel), 2022 Apr 24; 10(4). PMID: 35455289    Free PMC article.
A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors.
Justin B Hackett, James E Glassbrook, +7 authors, Heather M Gibson.
Oncoimmunology, 2022 Apr 29; 11(1). PMID: 35481286    Free PMC article.
Holistic Approach to Immune Checkpoint Inhibitor-Related Adverse Events.
Remo Poto, Teresa Troiani, +4 authors, Gilda Varricchi.
Front Immunol, 2022 Apr 19; 13. PMID: 35432346    Free PMC article.
Overcome tumor relapse in CAR T cell therapy.
Cheng-Dong Huo, Jie Yang, +3 authors, Yu-Min Li.
Clin Transl Oncol, 2022 Jun 10;. PMID: 35678948
Challenging Dermatologic Considerations Associated with Immune Checkpoint Inhibitors.
Benjamin C Park, Seungyeon Jung, +2 authors, Douglas B Johnson.
Am J Clin Dermatol, 2022 Jun 17;. PMID: 35708849