Journal Article
. 1994 Feb; 76(3):519-29.
doi: 10.1016/0092-8674(94)90115-5.

FcR gamma chain deletion results in pleiotrophic effector cell defects

T Takai 1 M Li  D Sylvestre  R Clynes  J V Ravetch  
Affiliations
  • PMID: 8313472
  •     340 citations

Abstract

The gamma subunit of immunoglobulin Fc receptors is an essential component of the high-affinity receptor for IgG (Fc gamma RIII) and is associated with the high-affinity receptor for IgG (Fc gamma RI) and the T cell receptor-CD3 complex. It is required for both receptor assembly and signal transduction. Targeted disruption of this subunit results in immunocompromised mice. Activated macrophages from gamma chain-deficient mice unexpectedly lack the ability to phagocytose antibody-coated particles, despite normal binding. Defects in NK cell-mediated antibody-dependent cytotoxicity and mast cell-mediated allergic responses are evident in these animals, establishing the indispensable role of FcRs in these responses. However, loss of gamma chain does not appear to perturb T cell development, since both thymic and peripheral T cell populations appear normal. These mice thus represent an important tool for evaluating the role of these receptors in humoral and cellular immune responses.

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Fc gamma receptors play a dominant role in protective tumor immunity against a virus-encoded tumor-specific antigen in a murine model of experimental pulmonary metastases.
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J Virol, 2006 Nov 17; 81(3). PMID: 17108042    Free PMC article.
Immunoglobulin G signaling activates lysosome/phagosome docking.
Vishal Trivedi, Shao C Zhang, +5 authors, Axel Nohturfft.
Proc Natl Acad Sci U S A, 2006 Nov 18; 103(48). PMID: 17110435    Free PMC article.
GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.
Sascha C Hughan, Craig E Hughes, +5 authors, Steve P Watson.
Arterioscler Thromb Vasc Biol, 2006 Nov 18; 27(2). PMID: 17110603    Free PMC article.
Activating and inhibitory FcgammaRs in autoimmune disorders.
Falk Nimmerjahn.
Springer Semin Immunopathol, 2006 Nov 23; 28(4). PMID: 17115158
Review.
Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1.
Peter A Nigrovic, Bryce A Binstadt, +6 authors, David M Lee.
Proc Natl Acad Sci U S A, 2007 Feb 06; 104(7). PMID: 17277081    Free PMC article.
Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation.
Ai Masuda, Akira Nakamura, +2 authors, Toshiyuki Takai.
J Exp Med, 2007 Apr 11; 204(4). PMID: 17420263    Free PMC article.
Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance.
Stephanie O Harbers, Andrea Crocker, +4 authors, Raphael Clynes.
J Clin Invest, 2007 Apr 21; 117(5). PMID: 17446931    Free PMC article.
Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells.
Kyung Min Chung, Bruce S Thompson, Daved H Fremont, Michael S Diamond.
J Virol, 2007 Jun 22; 81(17). PMID: 17582005    Free PMC article.
Extravasations and emigration of neutrophils to the inflammatory site depend on the interaction of immune-complex with Fcgamma receptors and can be effectively blocked by decoy Fcgamma receptors.
Rangaiah Shashidharamurthy, Randolph A Hennigar, +3 authors, Periasamy Selvaraj.
Blood, 2007 Oct 27; 111(2). PMID: 17962513    Free PMC article.
Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent.
Dongqi Xing, Fadi G Hage, +6 authors, Alexander J Szalai.
Am J Pathol, 2007 Dec 08; 172(1). PMID: 18063701    Free PMC article.
Perceiving the avidity of T cell activation can be translated into peripheral T cell regulation.
Weiling Chen, Linging Zhang, +4 authors, Hong Jiang.
Proc Natl Acad Sci U S A, 2007 Dec 14; 104(51). PMID: 18077361    Free PMC article.
Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma.
Ching-Liang Chu, Yen-Ling Yu, +3 authors, Jessica A Hamerman.
Eur J Immunol, 2007 Dec 18; 38(1). PMID: 18081038    Free PMC article.
Critical but overlapping role of FcgammaRIII and FcgammaRIV in activation of murine neutrophils by immobilized immune complexes.
Zoltán Jakus, Tamás Németh, J Sjef Verbeek, Attila Mócsai.
J Immunol, 2007 Dec 22; 180(1). PMID: 18097064    Free PMC article.
Neutrophils play an essential role in cooperation with antibody in both protection against and recovery from pulmonary infection with influenza virus in mice.
Haruo Fujisawa.
J Virol, 2008 Jan 11; 82(6). PMID: 18184718    Free PMC article.
Fcgamma receptor regulation of Citrobacter rodentium infection.
Atsuhiro Masuda, Masaru Yoshida, +15 authors, Takeshi Azuma.
Infect Immun, 2008 Jan 30; 76(4). PMID: 18227164    Free PMC article.
A role for NKG2D in NK cell-mediated resistance to poxvirus disease.
Min Fang, Lewis L Lanier, Luis J Sigal.
PLoS Pathog, 2008 Feb 13; 4(2). PMID: 18266471    Free PMC article.
The tec family tyrosine kinase Btk Regulates RANKL-induced osteoclast maturation.
Seoung Hoon Lee, Taesoo Kim, +2 authors, Yongwon Choi.
J Biol Chem, 2008 Feb 19; 283(17). PMID: 18281276    Free PMC article.
Macrophages express multiple ligands for gammadelta TCRs.
M Kemal Aydintug, Christina L Roark, +2 authors, Rebecca L O'Brien.
Mol Immunol, 2008 May 06; 45(11). PMID: 18455236    Free PMC article.
Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg.
David D Kim, Takashi Miwa, +3 authors, Wen-Chao Song.
Blood, 2008 Jun 06; 112(4). PMID: 18524992    Free PMC article.
Differential dephosphorylation of the FcRgamma immunoreceptor tyrosine-based activation motif tyrosines with dissimilar potential for activating Syk.
Toshiyuki Yamashita, Ryo Suzuki, +3 authors, Juan Rivera.
J Biol Chem, 2008 Aug 22; 283(42). PMID: 18715866    Free PMC article.
PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.
Alexander Zarbock, Clare L Abram, +3 authors, Klaus Ley.
J Exp Med, 2008 Sep 17; 205(10). PMID: 18794338    Free PMC article.
Increased IL-12 inhibits B cells' differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts.
Sun Jung Kim, Michele Caton, +4 authors, Betty Diamond.
J Exp Med, 2008 Sep 24; 205(10). PMID: 18809711    Free PMC article.
Identification of a receptor required for the anti-inflammatory activity of IVIG.
Robert M Anthony, Fredrik Wermeling, Mikael C I Karlsson, Jeffrey V Ravetch.
Proc Natl Acad Sci U S A, 2008 Nov 28; 105(50). PMID: 19036920    Free PMC article.
Highly Cited.
Improved tumor immunity using anti-tyrosinase related protein-1 monoclonal antibody combined with DNA vaccines in murine melanoma.
Yvonne M Saenger, Yanyun Li, +6 authors, Jedd D Wolchok.
Cancer Res, 2008 Dec 03; 68(23). PMID: 19047169    Free PMC article.
Peanuts can contribute to anaphylactic shock by activating complement.
Marat Khodoun, Richard Strait, +5 authors, Fred D Finkelman.
J Allergy Clin Immunol, 2009 Jan 06; 123(2). PMID: 19121857    Free PMC article.
Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation.
Kerstin Werninghaus, Anna Babiak, +15 authors, Roland Lang.
J Exp Med, 2009 Jan 14; 206(1). PMID: 19139169    Free PMC article.
Highly Cited.
Efficacy of opsonic and nonopsonic serotype 3 pneumococcal capsular polysaccharide-specific monoclonal antibodies against intranasal challenge with Streptococcus pneumoniae in mice.
Haijun Tian, Sarah Weber, +2 authors, Liise-Anne Pirofski.
Infect Immun, 2009 Jan 27; 77(4). PMID: 19168739    Free PMC article.
Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis.
Zoltán Jakus, Edina Simon, +2 authors, Attila Mócsai.
J Exp Med, 2009 Mar 11; 206(3). PMID: 19273622    Free PMC article.
Role of Fc Receptors as a therapeutic target.
Atsuhiro Masuda, Masaru Yoshida, +8 authors, Takeshi Azuma.
Inflamm Allergy Drug Targets, 2009 Mar 12; 8(1). PMID: 19275696    Free PMC article.
Review.
Effect of preexisting immunity on an adenovirus vaccine vector: in vitro neutralization assays fail to predict inhibition by antiviral antibody in vivo.
Susan L Pichla-Gollon, Shih-Wen Lin, +8 authors, Jeffrey M Bergelson.
J Virol, 2009 Mar 13; 83(11). PMID: 19279092    Free PMC article.
Impaired antibody response causes persistence of prototypic T cell-contained virus.
Andreas Bergthaler, Lukas Flatz, +14 authors, Daniel D Pinschewer.
PLoS Biol, 2009 Apr 10; 7(4). PMID: 19355789    Free PMC article.
Natural antibody contributes to host defense against an attenuated Brucella abortus virB mutant.
Hortensia G Rolán, Mariana N Xavier, Renato L Santos, Renée M Tsolis.
Infect Immun, 2009 Apr 15; 77(7). PMID: 19364836    Free PMC article.
Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells.
Melanie Rauch, Roxane Tussiwand, Nabil Bosco, Antonius G Rolink.
PLoS One, 2009 May 08; 4(5). PMID: 19421318    Free PMC article.
Antibody-mediated immunity to the obligate intracellular bacterial pathogen Coxiella burnetii is Fc receptor- and complement-independent.
Jeffrey G Shannon, Diane C Cockrell, +2 authors, Robert A Heinzen.
BMC Immunol, 2009 May 12; 10. PMID: 19426498    Free PMC article.
Cross-talk between TLR4 and FcgammaReceptorIII (CD16) pathways.
Daniel Rittirsch, Michael A Flierl, +8 authors, Peter A Ward.
PLoS Pathog, 2009 Jun 09; 5(6). PMID: 19503602    Free PMC article.
Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10.
John A Kelly, Mary E Griffin, +7 authors, Peter M Morganelli.
Cardiovasc Res, 2009 Sep 02; 85(1). PMID: 19720605    Free PMC article.
Small, mobile FcepsilonRI receptor aggregates are signaling competent.
Nicholas L Andrews, Janet R Pfeiffer, +6 authors, Diane S Lidke.
Immunity, 2009 Sep 15; 31(3). PMID: 19747859    Free PMC article.
Generation of CD8+ T cell-mediated immunity against idiotype-negative lymphoma escapees.
Bindu Varghese, Adam Widman, +5 authors, Ronald Levy.
Blood, 2009 Sep 19; 114(20). PMID: 19762487    Free PMC article.
The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms.
Bryce A Binstadt, Jennifer L Hebert, +3 authors, Diane Mathis.
Proc Natl Acad Sci U S A, 2009 Oct 07; 106(39). PMID: 19805369    Free PMC article.
A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicity.
Rich-Henry Schabowsky, Kutlu G Elpek, +7 authors, Haval Shirwan.
Vaccine, 2009 Oct 20; 28(2). PMID: 19836479    Free PMC article.
FcRgamma activation regulates inflammation-associated squamous carcinogenesis.
Pauline Andreu, Magnus Johansson, +11 authors, Lisa M Coussens.
Cancer Cell, 2010 Feb 09; 17(2). PMID: 20138013    Free PMC article.
Highly Cited.
In vivo veritas: the surprising roles of Fc receptors in immunity.
Jeffrey Ravetch.
Nat Immunol, 2010 Feb 17; 11(3). PMID: 20157296
Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate.
Hanne Schoenen, Barbara Bodendorfer, +10 authors, Roland Lang.
J Immunol, 2010 Feb 19; 184(6). PMID: 20164423    Free PMC article.
Highly Cited.
Enhancement of humoral and cellular immunity with an anti-glucocorticoid-induced tumour necrosis factor receptor monoclonal antibody.
Jose F Ponte, Paul Ponath, +7 authors, Michael Rosenzweig.
Immunology, 2010 Mar 06; 130(2). PMID: 20201988    Free PMC article.
Decreased NK Cell FcRgamma in HIV-1 infected individuals receiving combination antiretroviral therapy: a cross sectional study.
Edwin Leeansyah, Jingling Zhou, +3 authors, Anthony Jaworowski.
PLoS One, 2010 Mar 13; 5(3). PMID: 20224795    Free PMC article.
Fcgamma receptors modulate pulmonary inflammation by activating innate immune cells in murine hypersensitivity pneumonitis.
Hyo Jin Park, Hye Sung Kim, Doo Hyun Chung.
Immune Netw, 2010 Mar 17; 10(1). PMID: 20228933    Free PMC article.
Immune requirements of post-exposure immunization with modified vaccinia Ankara of lethally infected mice.
Henning Lauterbach, Ronny Kassub, +6 authors, Hubertus Hochrein.
PLoS One, 2010 Mar 20; 5(3). PMID: 20300179    Free PMC article.
Reciprocal regulation of activating and inhibitory Fc{gamma} receptors by TLR7/8 activation: implications for tumor immunotherapy.
Jonathan P Butchar, Payal Mehta, +12 authors, Susheela Tridandapani.
Clin Cancer Res, 2010 Mar 25; 16(7). PMID: 20332325    Free PMC article.
IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production.
Kenichiro Maeda, Harshini Mehta, Douglas A Drevets, K Mark Coggeshall.
Blood, 2010 Mar 31; 115(23). PMID: 20351305    Free PMC article.
Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo.
Ana P Castaño, Shuei-Liong Lin, +7 authors, Jeremy S Duffield.
Sci Transl Med, 2010 Apr 07; 1(5). PMID: 20368175    Free PMC article.
A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis.
Eric Boilard, Ying Lai, +14 authors, David M Lee.
EMBO Mol Med, 2010 May 01; 2(5). PMID: 20432503    Free PMC article.
Advances in the understanding of the Fc gamma receptors-mediated autoantibodies uptake.
Sabrina Lisi, Margherita Sisto, +2 authors, Massimo D'Amore.
Clin Exp Med, 2010 May 11; 11(1). PMID: 20454994
Review.
Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway.
Sapna Devi, Michael P Kuligowski, +4 authors, Michael J Hickey.
Am J Pathol, 2010 Jul 24; 177(3). PMID: 20651232    Free PMC article.
Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks.
Takeshi Wada, Kenji Ishiwata, +12 authors, Hajime Karasuyama.
J Clin Invest, 2010 Jul 29; 120(8). PMID: 20664169    Free PMC article.
Highly Cited.
Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis.
Richard C Chou, Nancy D Kim, +6 authors, Andrew D Luster.
Immunity, 2010 Aug 24; 33(2). PMID: 20727790    Free PMC article.
Highly Cited.
Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma.
Mark P Chao, Ash A Alizadeh, +17 authors, Ravindra Majeti.
Cell, 2010 Sep 04; 142(5). PMID: 20813259    Free PMC article.
Highly Cited.
Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5.
Yutaka Enomoto, Yoshinori Yamanishi, +9 authors, Jiro Kitaura.
J Biol Chem, 2010 Sep 08; 285(46). PMID: 20817736    Free PMC article.
A requirement for FcγR in antibody-mediated bacterial toxin neutralization.
Nareen Abboud, Siu-Kei Chow, +4 authors, Arturo Casadevall.
J Exp Med, 2010 Oct 06; 207(11). PMID: 20921285    Free PMC article.
Leukotriene B4 augments and restores Fc gammaRs-dependent phagocytosis in macrophages.
Fuyuki Okamoto, Kazuko Saeki, +2 authors, Takehiko Yokomizo.
J Biol Chem, 2010 Oct 21; 285(52). PMID: 20959460    Free PMC article.
FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo.
Falk Nimmerjahn, Anja Lux, +5 authors, Jeffrey V Ravetch.
Proc Natl Acad Sci U S A, 2010 Oct 27; 107(45). PMID: 20974962    Free PMC article.
Deficiency of activating Fcγ-receptors reduces hepatic clearance and deposition of IC and increases CIC levels in mercury-induced autoimmunity.
Klara Martinsson, Thomas Skogh, +3 authors, Per Hultman.
PLoS One, 2010 Oct 27; 5(10). PMID: 20976163    Free PMC article.
Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease.
Shuwen Cao, Shaji Theodore, David G Standaert.
Mol Neurodegener, 2010 Oct 28; 5. PMID: 20977765    Free PMC article.
Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting.
Nicole Joller, Stefan S Weber, +5 authors, Annette Oxenius.
Proc Natl Acad Sci U S A, 2010 Nov 05; 107(47). PMID: 21048081    Free PMC article.
Platelets participate in synovitis via Cox-1-dependent synthesis of prostacyclin independently of microparticle generation.
Eric Boilard, Katherine Larabee, +4 authors, David M Lee.
J Immunol, 2011 Mar 02; 186(7). PMID: 21357261    Free PMC article.
Insights into the regulatory mechanism controlling the inhibition of vaccine-induced seroconversion by maternal antibodies.
Dhohyung Kim, Devra Huey, Michael Oglesbee, Stefan Niewiesk.
Blood, 2011 Mar 02; 117(23). PMID: 21357766    Free PMC article.
Lentivector expressing HBsAg and immunoglobulin Fc fusion antigen induces potent immune responses and results in seroconversion in HBsAg transgenic mice.
Yuan Hong, Yibing Peng, +4 authors, Yukai He.
Vaccine, 2011 Mar 23; 29(22). PMID: 21421003    Free PMC article.
Phagocytic receptors dictate phagosomal escape and intracellular proliferation of Francisella tularensis.
Henriette Geier, Jean Celli.
Infect Immun, 2011 Mar 23; 79(6). PMID: 21422184    Free PMC article.
Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation.
Daigo Hashimoto, Andrew Chow, +13 authors, Miriam Merad.
J Exp Med, 2011 May 04; 208(5). PMID: 21536742    Free PMC article.
Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin.
Maria da Glória Sousa, Delyth M Reid, +7 authors, Gordon D Brown.
Cell Host Microbe, 2011 May 18; 9(5). PMID: 21575914    Free PMC article.
IgE immune complexes stimulate an increase in lung mast cell progenitors in a mouse model of allergic airway inflammation.
Joakim S Dahlin, Martin A Ivarsson, Birgitta Heyman, Jenny Hallgren.
PLoS One, 2011 Jun 01; 6(5). PMID: 21625525    Free PMC article.
Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism.
Derek W Cain, Pilar B Snowden, Gregory D Sempowski, Garnett Kelsoe.
PLoS One, 2011 Jun 10; 6(5). PMID: 21655273    Free PMC article.
Involvement of the Fc gamma receptor in a chronic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of dopaminergic loss.
Arman Lira, Jerzy Kulczycki, +2 authors, David S Park.
J Biol Chem, 2011 Jun 23; 286(33). PMID: 21693708    Free PMC article.
Administration of chinpi, a component of the herbal medicine ninjin-youei-to, reverses age-induced demyelination.
Nanako Sato, Chika Seiwa, +11 authors, Hiroaki Asou.
Evid Based Complement Alternat Med, 2011 Jul 30; 2011. PMID: 21799684    Free PMC article.
Inhibitory Fcγ receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies.
Fubin Li, Jeffrey V Ravetch.
Science, 2011 Aug 20; 333(6045). PMID: 21852502    Free PMC article.
Highly Cited.
MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice.
Richard T Strait, Wyenona Hicks, +8 authors, Fred D Finkelman.
J Exp Med, 2011 Oct 26; 208(12). PMID: 22025304    Free PMC article.
Attenuated atherosclerotic lesions in apoE-Fcγ-chain-deficient hyperlipidemic mouse model is associated with inhibition of Th17 cells and promotion of regulatory T cells.
Hang Pong Ng, Ramona L Burris, Shanmugam Nagarajan.
J Immunol, 2011 Nov 02; 187(11). PMID: 22043015    Free PMC article.
Scavenger receptor expressions in the kidneys of mice with lipoprotein glomerulopathy.
Yoshiro Miyahara, Shinsuke Nishimura, +3 authors, Takao Saito.
Clin Exp Nephrol, 2011 Nov 11; 16(1). PMID: 22072188
Hydrodynamic delivery of plasmid DNA encoding human FcγR-Ig dimers blocks immune-complex mediated inflammation in mice.
R Shashidharamurthy, D Machiah, +5 authors, P Selvaraj.
Gene Ther, 2011 Nov 25; 19(9). PMID: 22113315    Free PMC article.
Role of novel rat-specific Fc receptor in macrophage activation associated with crescentic glomerulonephritis.
Theresa H Page, Zelpha D'Souza, +5 authors, Jacques Behmoaras.
J Biol Chem, 2011 Dec 21; 287(8). PMID: 22184119    Free PMC article.
Increased survival and reduced renal injury in MRL/lpr mice treated with a human Fcγ receptor II (CD32) peptide.
Jun Xi, Gai P Zhang, +10 authors, Rui G Deng.
Immunology, 2012 Jan 13; 136(1). PMID: 22236212    Free PMC article.
Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond.
P Mark Hogarth, Geoffrey A Pietersz.
Nat Rev Drug Discov, 2012 Mar 31; 11(4). PMID: 22460124
Highly Cited. Review.
Perforin- and granzyme-mediated cytotoxic effector functions are essential for protection against Francisella tularensis following vaccination by the defined F. tularensis subsp. novicida ΔfopC vaccine strain.
Shilpa Sanapala, Jieh-Juen Yu, +5 authors, Bernard P Arulanandam.
Infect Immun, 2012 Apr 12; 80(6). PMID: 22493083    Free PMC article.
Mast cells and company.
Friederike Jönsson, Marc Daëron.
Front Immunol, 2012 May 09; 3. PMID: 22566901    Free PMC article.
Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction.
Jessica L Teeling, Roxana O Carare, Martin J Glennie, V Hugh Perry.
Acta Neuropathol, 2012 May 24; 124(4). PMID: 22618994    Free PMC article.
Fcγ receptor deficiency attenuates diabetic nephropathy.
Virginia Lopez-Parra, Beñat Mallavia, +7 authors, Carmen Gomez-Guerrero.
J Am Soc Nephrol, 2012 Aug 04; 23(9). PMID: 22859852    Free PMC article.
Trichinella spiralis secreted enzymes regulate nucleotide-induced mast cell activation and release of mouse mast cell protease 1.
Holly C Afferson, Emily Eleftheriou, Murray E Selkirk, Kleoniki Gounaris.
Infect Immun, 2012 Aug 15; 80(11). PMID: 22890994    Free PMC article.
Inhibition of TGF-β enhances the in vivo antitumor efficacy of EGF receptor-targeted therapy.
Atul Bedi, Xiaofei Chang, +9 authors, Rajani Ravi.
Mol Cancer Ther, 2012 Aug 29; 11(11). PMID: 22927667    Free PMC article.
Antibodies and IL-3 support helminth-induced basophil expansion.
Tina Herbst, Julia Esser, +12 authors, Nicola L Harris.
Proc Natl Acad Sci U S A, 2012 Aug 30; 109(37). PMID: 22930820    Free PMC article.
Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency.
Florencia Rosetti, Naotake Tsuboi, +12 authors, Tanya N Mayadas.
J Immunol, 2012 Aug 31; 189(7). PMID: 22933624    Free PMC article.
Regulation of allograft survival by inhibitory FcγRIIb signaling.
Chris J Callaghan, Thet Su Win, +9 authors, Gavin J Pettigrew.
J Immunol, 2012 Nov 15; 189(12). PMID: 23150718    Free PMC article.
The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia.
Shuwen Cao, David G Standaert, Ashley S Harms.
J Neuroinflammation, 2012 Nov 29; 9. PMID: 23186369    Free PMC article.
Mechanisms of action of CD20 antibodies.
Peter Boross, Jeanette H W Leusen.
Am J Cancer Res, 2012 Dec 12; 2(6). PMID: 23226614    Free PMC article.
Autoantibody-mediated arthritis in the absence of C3 and activating Fcγ receptors: C5 is activated by the coagulation cascade.
Jennifer L Auger, Stefanie Haasken, Bryce A Binstadt.
Arthritis Res Ther, 2012 Dec 15; 14(6). PMID: 23237573    Free PMC article.
Differential role of lipocalin 2 during immune complex-mediated acute and chronic inflammation in mice.
Rangaiah Shashidharamurthy, Deepa Machiah, +6 authors, Matam Vijay-Kumar.
Arthritis Rheum, 2013 Jan 03; 65(4). PMID: 23280250    Free PMC article.
Cutting edge: antibody-dependent memory-like NK cells distinguished by FcRγ deficiency.
Tianxiang Zhang, Jeannine M Scott, Ilwoong Hwang, Sungjin Kim.
J Immunol, 2013 Jan 25; 190(4). PMID: 23345329    Free PMC article.
Highly Cited.
The orchestrated functions of innate leukocytes and T cell subsets contribute to humoral immunity, virus control, and recovery from secondary poxvirus challenge.
Vikas Tahiliani, Geeta Chaudhri, Preethi Eldi, Gunasegaran Karupiah.
J Virol, 2013 Jan 25; 87(7). PMID: 23345522    Free PMC article.
Application of knockout mouse models to investigate the influence of FcγR on the pharmacokinetics and anti-platelet effects of MWReg30, a monoclonal anti-GPIIb antibody.
Lubna Abuqayyas, Xiaoyan Zhang, Joseph P Balthasar.
Int J Pharm, 2013 Feb 02; 444(1-2). PMID: 23370434    Free PMC article.
Human CD300C delivers an Fc receptor-γ-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition.
Mariko Takahashi, Kumi Izawa, +14 authors, Jiro Kitaura.
J Biol Chem, 2013 Feb 02; 288(11). PMID: 23372157    Free PMC article.
Intravenous immunoglobulin therapy: how does IgG modulate the immune system?
Inessa Schwab, Falk Nimmerjahn.
Nat Rev Immunol, 2013 Feb 16; 13(3). PMID: 23411799
Highly Cited. Review.
B cells and their mediators as targets for therapy in solid tumors.
Andrew J Gunderson, Lisa M Coussens.
Exp Cell Res, 2013 Mar 19; 319(11). PMID: 23499742    Free PMC article.
Review.
The mature virion of ectromelia virus, a pathogenic poxvirus, is capable of intrahepatic spread and can serve as a target for delayed therapy.
Xueying Ma, Ren-Huan Xu, +4 authors, Luis J Sigal.
J Virol, 2013 Apr 19; 87(12). PMID: 23596297    Free PMC article.
Disease-enhancing antibodies improve the efficacy of bacterial toxin-neutralizing antibodies.
Siu-Kei Chow, Cameron Smith, +3 authors, Arturo Casadevall.
Cell Host Microbe, 2013 Apr 23; 13(4). PMID: 23601104    Free PMC article.
IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R.
Christopher E Martin, Ester M M van Leeuwen, +3 authors, Charles D Surh.
Blood, 2013 Apr 24; 121(22). PMID: 23610371    Free PMC article.
IgG and IgE collaboratively accelerate expulsion of Strongyloides venezuelensis in a primary infection.
Makoto Matsumoto, Yuki Sasaki, +4 authors, Kenji Nakanishi.
Infect Immun, 2013 May 01; 81(7). PMID: 23630966    Free PMC article.
Intranasal administration of antibody-bound respiratory syncytial virus particles efficiently primes virus-specific immune responses in mice.
Debby Kruijsen, Helga K Einarsdottir, +4 authors, Grada M van Bleek.
J Virol, 2013 May 03; 87(13). PMID: 23637394    Free PMC article.
FcγRI is required for TGFβ2-treated macrophage-induced tolerance.
Z Gu, A Y Chhabra, +2 authors, M M Kosiewicz.
Immunobiology, 2013 May 07; 218(9). PMID: 23643295    Free PMC article.
Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines.
D Hannani, C Locher, +9 authors, L Zitvogel.
Cell Death Differ, 2013 Jun 08; 21(1). PMID: 23744294    Free PMC article.
FcRγ controls the fas-dependent regulatory function of lymphoproliferative double negative T cells.
Stephen C Juvet, Christopher W Thomson, +2 authors, Li Zhang.
PLoS One, 2013 Jun 14; 8(6). PMID: 23762329    Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice.
Irene Kyrmizi, Marianna Ioannou, +3 authors, Ioannis Tassiulas.
J Leukoc Biol, 2013 Jul 31; 94(4). PMID: 23898046    Free PMC article.
Absence of FcγRIII results in increased proinflammatory response in FcγRIII-KO cardiac recipients.
Melek M Erdinc Sunay, Karen Fox-Talbot, +2 authors, Barbara A Wasowska.
Transplantation, 2013 Aug 02; 96(7). PMID: 23903009    Free PMC article.
Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome.
David Llewellyn, Simone C de Cassan, +6 authors, Simon J Draper.
J Leukoc Biol, 2013 Oct 29; 95(2). PMID: 24163420    Free PMC article.
The skin is an important bulwark of acquired immunity against intestinal helminths.
Kazushige Obata-Ninomiya, Kenji Ishiwata, +8 authors, Hajime Karasuyama.
J Exp Med, 2013 Oct 30; 210(12). PMID: 24166714    Free PMC article.
Antibodies trap tissue migrating helminth larvae and prevent tissue damage by driving IL-4Rα-independent alternative differentiation of macrophages.
Julia Esser-von Bieren, Ilaria Mosconi, +7 authors, Nicola L Harris.
PLoS Pathog, 2013 Nov 19; 9(11). PMID: 24244174    Free PMC article.
Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo.
David J DiLillo, Gene S Tan, Peter Palese, Jeffrey V Ravetch.
Nat Med, 2014 Jan 15; 20(2). PMID: 24412922    Free PMC article.
Highly Cited.
Type II phosphatidylinositol 4-kinases interact with FcεRIγ subunit in RBL-2H3 cells.
Naveen Bojjireddy, Ranjeet Kumar Sinha, Gosukonda Subrahmanyam.
Mol Cell Biochem, 2014 Feb 01; 390(1-2). PMID: 24481753
Fcγ receptor-mediated inflammation inhibits axon regeneration.
Gang Zhang, Nataliia Bogdanova, +4 authors, Kazim A Sheikh.
PLoS One, 2014 Feb 14; 9(2). PMID: 24523933    Free PMC article.
Role of FcγRIIIA (CD16) in IVIg-mediated anti-inflammatory function.
Sanae Ben Mkaddem, Meryem Aloulou, Marc Benhamou, Renato C Monteiro.
J Clin Immunol, 2014 Apr 15; 34 Suppl 1. PMID: 24728843
Review.
Fcγ receptor III and Fcγ receptor IV on macrophages drive autoimmune valvular carditis in mice.
Patricia M Hobday, Jennifer L Auger, +3 authors, Bryce A Binstadt.
Arthritis Rheumatol, 2014 Apr 24; 66(4). PMID: 24757138    Free PMC article.
DAP12 deficiency in liver allografts results in enhanced donor DC migration, augmented effector T cell responses and abrogation of transplant tolerance.
O Yoshida, S Kimura, +5 authors, A W Thomson.
Am J Transplant, 2014 Jun 18; 14(8). PMID: 24935196    Free PMC article.
Dual role for Fcγ receptors in host defense and disease in Borrelia burgdorferi-infected mice.
Alexia A Belperron, Nengyin Liu, Carmen J Booth, Linda K Bockenstedt.
Front Cell Infect Microbiol, 2014 Jun 27; 4. PMID: 24967215    Free PMC article.
Prolonged antigen presentation by immune complex-binding dendritic cells programs the proliferative capacity of memory CD8 T cells.
Beatriz León, André Ballesteros-Tato, Troy D Randall, Frances E Lund.
J Exp Med, 2014 Jul 09; 211(8). PMID: 25002751    Free PMC article.
Scavenger receptor function of mouse Fcγ receptor III contributes to progression of atherosclerosis in apolipoprotein E hyperlipidemic mice.
Xinmei Zhu, Hang Pong Ng, +4 authors, Shanmugam Nagarajan.
J Immunol, 2014 Jul 20; 193(5). PMID: 25038257    Free PMC article.
Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus.
Tony N Marion, Arnold E Postlethwaite.
Semin Immunopathol, 2014 Aug 12; 36(5). PMID: 25102991
Review.
Systemic CD8+ T cell-mediated tumoricidal effects by intratumoral treatment of oncolytic herpes simplex virus with the agonistic monoclonal antibody for murine glucocorticoid-induced tumor necrosis factor receptor.
Mikiya Ishihara, Naohiro Seo, +5 authors, Hiroshi Shiku.
PLoS One, 2014 Aug 12; 9(8). PMID: 25105508    Free PMC article.
Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration.
Naoya Totsuka, Yun-Gi Kim, +9 authors, Akira Shibuya.
Nat Commun, 2014 Aug 20; 5. PMID: 25134989    Free PMC article.
New roles for Fc receptors in neurodegeneration-the impact on Immunotherapy for Alzheimer's Disease.
James P Fuller, Jeffrey B Stavenhagen, Jessica L Teeling.
Front Neurosci, 2014 Sep 06; 8. PMID: 25191216    Free PMC article.
Review.
The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
Miklós Kovács, Tamás Németh, +7 authors, Attila Mócsai.
J Exp Med, 2014 Sep 17; 211(10). PMID: 25225462    Free PMC article.
Immune complexes inhibit IL-1 secretion and inflammasome activation.
John R Janczy, Ceren Ciraci, +4 authors, Fayyaz S Sutterwala.
J Immunol, 2014 Oct 17; 193(10). PMID: 25320279    Free PMC article.
Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion.
Christian Schwartz, Adriana Turqueti-Neves, +3 authors, David Voehringer.
Proc Natl Acad Sci U S A, 2014 Nov 19; 111(48). PMID: 25404305    Free PMC article.
α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosis.
Robin J Marjoram, Zhengzhi Li, +5 authors, Mary M Zutter.
PLoS One, 2014 Nov 22; 9(11). PMID: 25415203    Free PMC article.
The non-receptor tyrosine kinase Tec controls assembly and activity of the noncanonical caspase-8 inflammasome.
Florian Zwolanek, Michael Riedelberger, +5 authors, Karl Kuchler.
PLoS Pathog, 2014 Dec 05; 10(12). PMID: 25474208    Free PMC article.
Absence of Dap12 and the αvβ3 integrin causes severe osteopetrosis.
Wei Zou, Steven L Teitelbaum.
J Cell Biol, 2014 Dec 31; 208(1). PMID: 25547154    Free PMC article.
Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response.
Kalani Halemano, Bradley S Barrett, +2 authors, Mario L Santiago.
J Virol, 2015 Jan 16; 89(7). PMID: 25589647    Free PMC article.
Requirement for innate immunity and CD90⁺ NK1.1⁻ lymphocytes to treat established melanoma with chemo-immunotherapy.
Marina Moskalenko, Michael Pan, +11 authors, Yvonne Saenger.
Cancer Immunol Res, 2015 Jan 21; 3(3). PMID: 25600438    Free PMC article.
The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.
Anne Rabes, Stephanie Zimmermann, +6 authors, Bastian Opitz.
PLoS One, 2015 Feb 07; 10(2). PMID: 25658823    Free PMC article.
Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity.
Saranya Elavazhagan, Kavin Fatehchand, +14 authors, Susheela Tridandapani.
J Immunol, 2015 Feb 11; 194(6). PMID: 25667415    Free PMC article.
Rickettsia rickettsii outer membrane protein YbgF induces protective immunity in C3H/HeN mice.
Wenping Gong, Yong Qi, +3 authors, Bohai Wen.
Hum Vaccin Immunother, 2015 Feb 26; 11(3). PMID: 25714655    Free PMC article.
Reduced Atherosclerosis in apoE-inhibitory FcγRIIb-Deficient Mice Is Associated With Increased Anti-Inflammatory Responses by T Cells and Macrophages.
Hang Pong Ng, Xinmei Zhu, +2 authors, Shanmugam Nagarajan.
Arterioscler Thromb Vasc Biol, 2015 Mar 21; 35(5). PMID: 25792447    Free PMC article.
Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization.
Viola Lorenz, David Stegner, +7 authors, Bernhard Nieswandt.
Blood, 2015 Mar 22; 125(26). PMID: 25795918    Free PMC article.
Immune complexes regulate bone metabolism through FcRγ signalling.
Takako Negishi-Koga, Hans-Jürgen Gober, +8 authors, Hiroshi Takayanagi.
Nat Commun, 2015 Apr 01; 6. PMID: 25824719
Platelets convert peripheral blood circulating monocytes to regulatory cells via immunoglobulin G and activating-type Fcγ receptors.
Masanori Inui, Kino Tazawa, Yoshiro Kishi, Toshiyuki Takai.
BMC Immunol, 2015 Apr 22; 16. PMID: 25896516    Free PMC article.
Chloroform-Methanol Residue of Coxiella burnetii Markedly Potentiated the Specific Immunoprotection Elicited by a Recombinant Protein Fragment rOmpB-4 Derived from Outer Membrane Protein B of Rickettsia rickettsii in C3H/HeN Mice.
Wenping Gong, Pengcheng Wang, +3 authors, Bohai Wen.
PLoS One, 2015 Apr 25; 10(4). PMID: 25909586    Free PMC article.
Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect.
David J DiLillo, Jeffrey V Ravetch.
Cell, 2015 May 16; 161(5). PMID: 25976835    Free PMC article.
Highly Cited.
Impaired Fracture Healing Caused by Deficiency of the Immunoreceptor Adaptor Protein DAP12.
Masayuki Kamimura, Yu Mori, +2 authors, Eiji Itoi.
PLoS One, 2015 Jun 02; 10(6). PMID: 26030755    Free PMC article.
Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake.
Kristen E Funk, Hilda Mirbaha, +2 authors, Marc I Diamond.
J Biol Chem, 2015 Jul 02; 290(35). PMID: 26126828    Free PMC article.
Retention of duplicated ITAM-containing transmembrane signaling subunits in the tetraploid amphibian species Xenopus laevis.
S V Guselnikov, L Grayfer, +3 authors, A V Taranin.
Dev Comp Immunol, 2015 Jul 15; 53(1). PMID: 26170006    Free PMC article.
Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity.
Isaak Quast, Christian W Keller, +7 authors, Jan D Lünemann.
J Clin Invest, 2015 Oct 06; 125(11). PMID: 26436649    Free PMC article.
Highly Cited.
Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.
Tangsheng Yi, Jianhua Li, +6 authors, Jason G Cyster.
Immunity, 2015 Oct 11; 43(4). PMID: 26453377    Free PMC article.
IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors.
Joakim J E Bergström, Birgitta Heyman.
PLoS One, 2015 Dec 01; 10(11). PMID: 26619292    Free PMC article.
Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination.
Kavin Fatehchand, Li Ren, +7 authors, Jonathan P Butchar.
J Biol Chem, 2015 Dec 24; 291(8). PMID: 26694610    Free PMC article.
Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer.
Andrew J Gunderson, Megan M Kaneda, +15 authors, Lisa M Coussens.
Cancer Discov, 2015 Dec 31; 6(3). PMID: 26715645    Free PMC article.
Highly Cited.
Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection.
David J DiLillo, Peter Palese, Patrick C Wilson, Jeffrey V Ravetch.
J Clin Invest, 2016 Jan 06; 126(2). PMID: 26731473    Free PMC article.
Highly Cited.
NK Cell-Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines.
Alena C Jaime-Ramirez, Elizabeth McMichael, +26 authors, William E Carson.
Cancer Immunol Res, 2016 Feb 13; 4(4). PMID: 26865456    Free PMC article.
Protection from experimental autoimmune encephalomyelitis by polyclonal IgG requires adjuvant-induced inflammation.
Isaak Quast, Christian W Keller, +3 authors, Jan D Lünemann.
J Neuroinflammation, 2016 Feb 20; 13. PMID: 26893156    Free PMC article.
Biochemical and Functional Insights into the Integrated Regulation of Innate Immune Cell Responses by Teleost Leukocyte Immune-Type Receptors.
Chenjie Fei, Joshua G Pemberton, +2 authors, James L Stafford.
Biology (Basel), 2016 Mar 24; 5(1). PMID: 27005670    Free PMC article.
Review.
Anti-CD25 monoclonal antibody Fc variants differentially impact regulatory T cells and immune homeostasis.
David J Huss, Alex F Pellerin, +5 authors, Jason D Fontenot.
Immunology, 2016 Mar 26; 148(3). PMID: 27012310    Free PMC article.
Folate-conjugated immunoglobulin targets melanoma tumor cells for NK cell effector functions.
Cassandra C Skinner, Elizabeth L McMichael, +3 authors, William E Carson.
Melanoma Res, 2016 Apr 02; 26(4). PMID: 27035691    Free PMC article.
Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus.
SunAh Kang, Jennifer L Rogers, +8 authors, Barbara J Vilen.
J Immunol, 2016 Apr 10; 196(10). PMID: 27059595    Free PMC article.
FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.
Madeleen Bosma, Marco Gerling, +10 authors, Pontus Almer Boström.
Nat Commun, 2016 Apr 14; 7. PMID: 27066907    Free PMC article.
TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin.
Toshiki Yabe-Wada, Shintaro Matsuba, +7 authors, Akira Nakamura.
Sci Rep, 2016 May 26; 6. PMID: 27220277    Free PMC article.
Anti-CD137 enhances anti-CD20 therapy of systemic B-cell lymphoma with altered immune homeostasis but negligible toxicity.
Fernando Souza-Fonseca-Guimaraes, Stephen J Blake, +3 authors, Mark J Smyth.
Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622048    Free PMC article.
Regulation of FcRγ function by site-specific serine phosphorylation.
Spandan Shah, Andrew W Gibson, +5 authors, Robert P Kimberly.
J Leukoc Biol, 2016 Sep 16; 101(2). PMID: 27630214    Free PMC article.
Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection.
Salvador Iborra, María Martínez-López, +13 authors, David Sancho.
Immunity, 2016 Oct 21; 45(4). PMID: 27742545    Free PMC article.
Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines.
Masayuki Hayashi, Taiki Aoshi, +13 authors, Ken J Ishii.
EBioMedicine, 2016 Dec 07; 15. PMID: 27919753    Free PMC article.
FcRγ-dependent immune activation initiates astrogliosis during the asymptomatic phase of Sandhoff disease model mice.
Yasuhiro Ogawa, Takafumi Sano, +11 authors, Kazuhiko Oishi.
Sci Rep, 2017 Jan 14; 7. PMID: 28084424    Free PMC article.
The Role and Function of Fcγ Receptors on Myeloid Cells.
Stylianos Bournazos, Taia T Wang, Jeffrey V Ravetch.
Microbiol Spectr, 2017 Jan 15; 4(6). PMID: 28087938    Free PMC article.
Review.
Targeted Fcγ Receptor (FcγR)-mediated Clearance by a Biparatopic Bispecific Antibody.
Srinath Kasturirangan, G Jonah Rainey, +10 authors, Changshou Gao.
J Biol Chem, 2017 Jan 20; 292(10). PMID: 28100773    Free PMC article.
Modulation of Microglial Cell Fcγ Receptor Expression Following Viral Brain Infection.
Priyanka Chauhan, Shuxian Hu, +2 authors, James R Lokensgard.
Sci Rep, 2017 Feb 07; 7. PMID: 28165503    Free PMC article.
Therapeutic antibody targeting of indoleamine-2,3-dioxygenase (IDO2) inhibits autoimmune arthritis.
Lauren M F Merlo, Samantha Grabler, +5 authors, Laura Mandik-Nayak.
Clin Immunol, 2017 Feb 23; 179. PMID: 28223071    Free PMC article.
Differences in the Importance of Mast Cells, Basophils, IgE, and IgG versus That of CD4+ T Cells and ILC2 Cells in Primary and Secondary Immunity to Strongyloides venezuelensis.
Kaori Mukai, Hajime Karasuyama, +2 authors, Stephen J Galli.
Infect Immun, 2017 Mar 08; 85(5). PMID: 28264908    Free PMC article.
Epitope-Specific Suppression of IgG Responses by Passively Administered Specific IgG: Evidence of Epitope Masking.
Joakim J E Bergström, Hui Xu, Birgitta Heyman.
Front Immunol, 2017 Mar 23; 8. PMID: 28321225    Free PMC article.
DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.
Christian H K Lehmann, Anna Baranska, +15 authors, Diana Dudziak.
J Exp Med, 2017 Apr 09; 214(5). PMID: 28389502    Free PMC article.
SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin.
Jun Chen, Ming-Chao Zhong, +14 authors, André Veillette.
Nature, 2017 Apr 21; 544(7651). PMID: 28424516    Free PMC article.
Highly Cited.
Signaling by Antibodies: Recent Progress.
Stylianos Bournazos, Taia T Wang, +2 authors, Jeffrey V Ravetch.
Annu Rev Immunol, 2017 Apr 28; 35. PMID: 28446061    Free PMC article.
Highly Cited. Review.
Autoantibody-induced internalization of CNS AQP4 water channel and EAAT2 glutamate transporter requires astrocytic Fc receptor.
Shannon R Hinson, Ian C Clift, +2 authors, Vanda A Lennon.
Proc Natl Acad Sci U S A, 2017 May 04; 114(21). PMID: 28461494    Free PMC article.
Diversification of IgG effector functions.
Stylianos Bournazos, Jeffrey V Ravetch.
Int Immunol, 2017 May 05; 29(7). PMID: 28472280    Free PMC article.
Review.
Toll-Like Receptor 2 and Mincle Cooperatively Sense Corynebacterial Cell Wall Glycolipids.
Judith Schick, Philipp Etschel, +6 authors, Roland Lang.
Infect Immun, 2017 May 10; 85(7). PMID: 28483856    Free PMC article.
B Cell-Extrinsic Myd88 and Fcer1g Negatively Regulate Autoreactive and Normal B Cell Immune Responses.
Rebecca A Sweet, Kevin M Nickerson, +2 authors, Mark J Shlomchik.
J Immunol, 2017 Jul 01; 199(3). PMID: 28659358    Free PMC article.
Fcγ Receptor Function and the Design of Vaccination Strategies.
Stylianos Bournazos, Jeffrey V Ravetch.
Immunity, 2017 Aug 17; 47(2). PMID: 28813656    Free PMC article.
Highly Cited. Review.
Therapeutic Potential of Intravenous Immunoglobulin in Acute Brain Injury.
Vivien Thom, Thiruma V Arumugam, Tim Magnus, Mathias Gelderblom.
Front Immunol, 2017 Aug 22; 8. PMID: 28824617    Free PMC article.
Review.
Syk-dependent tyrosine phosphorylation of 3BP2 is required for optimal FcRγ-mediated phagocytosis and chemokine expression in U937 cells.
Kazuyasu Chihara, Yuji Kato, +3 authors, Kiyonao Sada.
Sci Rep, 2017 Sep 15; 7(1). PMID: 28904407    Free PMC article.
In Vitro Neutralization Is Not Predictive of Prophylactic Efficacy of Broadly Neutralizing Monoclonal Antibodies CR6261 and CR9114 against Lethal H2 Influenza Virus Challenge in Mice.
Troy C Sutton, Elaine W Lamirande, +6 authors, Kanta Subbarao.
J Virol, 2017 Oct 20; 91(24). PMID: 29046448    Free PMC article.
Therapeutic Antibodies: What Have We Learnt from Targeting CD20 and Where Are We Going?
Michael J E Marshall, Richard J Stopforth, Mark S Cragg.
Front Immunol, 2017 Oct 20; 8. PMID: 29046676    Free PMC article.
Review.
Skin CD4+ Memory T Cells Play an Essential Role in Acquired Anti-Tick Immunity through Interleukin-3-Mediated Basophil Recruitment to Tick-Feeding Sites.
Takuya Ohta, Soichiro Yoshikawa, +12 authors, Hajime Karasuyama.
Front Immunol, 2017 Nov 01; 8. PMID: 29085376    Free PMC article.
STAT4 and T-bet control follicular helper T cell development in viral infections.
Jason S Weinstein, Brian J Laidlaw, +7 authors, Joe Craft.
J Exp Med, 2017 Dec 08; 215(1). PMID: 29212666    Free PMC article.
The CD300e molecule in mice is an immune-activating receptor.
Masamichi Isobe, Kumi Izawa, +19 authors, Jiro Kitaura.
J Biol Chem, 2018 Jan 24; 293(10). PMID: 29358324    Free PMC article.
A Restricted Role for FcγR in the Regulation of Adaptive Immunity.
Marieke F Fransen, Hreinn Benonisson, +25 authors, J Sjef Verbeek.
J Immunol, 2018 Mar 11; 200(8). PMID: 29523656    Free PMC article.
CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity.
Amelia Roman Aguilera, Viviana P Lutzky, +7 authors, Mark J Smyth.
Oncoimmunology, 2018 May 04; 7(5). PMID: 29721390    Free PMC article.
Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells.
Ayako Kaitani, Kumi Izawa, +19 authors, Jiro Kitaura.
Sci Rep, 2018 May 31; 8(1). PMID: 29844322    Free PMC article.
Murine macrophage TLR2-FcγR synergy via FcγR licensing of IL-6 cytokine mRNA ribosome binding and translation.
Danielle Hunt, Lisa A Drake, James R Drake.
PLoS One, 2018 Jul 20; 13(7). PMID: 30024985    Free PMC article.
Non-neutralizing antibodies elicited by recombinant Lassa-Rabies vaccine are critical for protection against Lassa fever.
Tiago Abreu-Mota, Katie R Hagen, +5 authors, Matthias J Schnell.
Nat Commun, 2018 Oct 13; 9(1). PMID: 30310067    Free PMC article.
Vaccine synergy with virus-like particle and immune complex platforms for delivery of human papillomavirus L2 antigen.
Andrew G Diamos, Dalia Larios, +5 authors, Hugh S Mason.
Vaccine, 2018 Nov 22; 37(1). PMID: 30459071    Free PMC article.
Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment.
Gurpanna Saggu, Koshu Okubo, +12 authors, Tanya N Mayadas.
Nat Commun, 2018 Dec 01; 9(1). PMID: 30498196    Free PMC article.
Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model.
Sachiko Ono, Gyohei Egawa, +11 authors, Kenji Kabashima.
Nat Commun, 2019 Oct 02; 10(1). PMID: 31570755    Free PMC article.
C-Reactive Protein Promotes the Expansion of Myeloid Derived Cells With Suppressor Functions.
Rachel V Jimenez, Valeriya Kuznetsova, +2 authors, Alexander J Szalai.
Front Immunol, 2019 Oct 18; 10. PMID: 31620123    Free PMC article.
The Complex Association of FcγRIIb With Autoimmune Susceptibility.
J Sjef Verbeek, Sachiko Hirose, Hiroyuki Nishimura.
Front Immunol, 2019 Nov 05; 10. PMID: 31681256    Free PMC article.
Review.
Targeted inhibition of CD47-SIRPα requires Fc-FcγR interactions to maximize activity in T-cell lymphomas.
Salvia Jain, Alexandria Van Scoyk, +10 authors, David M Weinstock.
Blood, 2019 Aug 07; 134(17). PMID: 31383641    Free PMC article.
Impact of Itga2-Gp6-double collagen receptor deficient mice for bone marrow megakaryocytes and platelets.
Daniela Semeniak, Kristina Faber, +2 authors, Harald Schulze.
PLoS One, 2019 Aug 10; 14(8). PMID: 31398205    Free PMC article.
There Is (Scientific) Strength in Numbers: A Comprehensive Quantitation of Fc Gamma Receptor Numbers on Human and Murine Peripheral Blood Leukocytes.
Christina Kerntke, Falk Nimmerjahn, Markus Biburger.
Front Immunol, 2020 Mar 03; 11. PMID: 32117269    Free PMC article.
Passive immunization with influenza haemagglutinin specific monoclonal antibodies.
Rajeev Rudraraju, Kanta Subbarao.
Hum Vaccin Immunother, 2018 Jul 10; 14(11). PMID: 29985756    Free PMC article.
A Recombinant Rabies Virus Expressing the Marburg Virus Glycoprotein Is Dependent upon Antibody-Mediated Cellular Cytotoxicity for Protection against Marburg Virus Disease in a Murine Model.
Rohan Keshwara, Katie R Hagen, +5 authors, Matthias J Schnell.
J Virol, 2018 Dec 21; 93(6). PMID: 30567978    Free PMC article.
Age-Related Differential Stimulation of Immune Response by Babesia microti and Borrelia burgdorferi During Acute Phase of Infection Affects Disease Severity.
Vitomir Djokic, Shekerah Primus, +2 authors, Nikhat Parveen.
Front Immunol, 2019 Jan 09; 9. PMID: 30619263    Free PMC article.
Leukemic B Cell CTLA-4 Suppresses Costimulation of T Cells.
Priscilla Do, Kyle A Beckwith, +9 authors, John C Byrd.
J Immunol, 2019 Mar 27; 202(9). PMID: 30910862    Free PMC article.
NK cell-intrinsic FcεRIγ limits CD8+ T-cell expansion and thereby turns an acute into a chronic viral infection.
Vikas Duhan, Thamer A Hamdan, +10 authors, Karl S Lang.
PLoS Pathog, 2019 Jun 21; 15(6). PMID: 31220194    Free PMC article.
Immunization with DNA prime-subunit protein boost strategy based on influenza H9N2 virus conserved matrix protein M1 and its epitope screening.
Fen Liu, Xueliang Wang, +5 authors, Ze Chen.
Sci Rep, 2020 Mar 07; 10(1). PMID: 32139720    Free PMC article.
Fc receptors as adaptive immunoreceptors.
Marc Daëron.
Curr Top Microbiol Immunol, 2014 Aug 15; 382. PMID: 25116099    Free PMC article.
Review.
Importance of Fc Receptor γ-Chain ITAM Tyrosines in Neutrophil Activation and in vivo Autoimmune Arthritis.
Tamás Németh, Krisztina Futosi, +4 authors, Zoltán Jakus.
Front Immunol, 2019 Mar 13; 10. PMID: 30858848    Free PMC article.
Combination Therapy for Treating Advanced Drug-Resistant Acute Lymphoblastic Leukemia.
Yorleny Vicioso, Hermann Gram, +5 authors, Reshmi Parameswaran.
Cancer Immunol Res, 2019 May 30; 7(7). PMID: 31138521    Free PMC article.
The Diverse Functions of the Ubiquitous Fcγ Receptors and Their Unique Constituent, FcRγ Subunit.
Thamer A Hamdan, Philipp A Lang, Karl S Lang.
Pathogens, 2020 Feb 26; 9(2). PMID: 32093173    Free PMC article.
Review.
Herpesviral Fcgamma receptors: culprits attenuating antiviral IgG?
Matthias Budt, Henrike Reinhard, Arndt Bigl, Hartmut Hengel.
Int Immunopharmacol, 2004 Jul 15; 4(9). PMID: 15251110    Free PMC article.
Evolutionary Story of the Low/Medium-Affinity IgG Fc Receptor Gene Cluster.
Julien Lejeune, Guillaume Brachet, Hervé Watier.
Front Immunol, 2019 Jun 28; 10. PMID: 31244843    Free PMC article.
Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons.
Alex Bersellini Farinotti, Gustaf Wigerblad, +28 authors, Camilla I Svensson.
J Exp Med, 2019 Jun 15; 216(8). PMID: 31196979    Free PMC article.
FcγRII (CD32) modulates antibody clearance in NOD SCID mice leading to impaired antibody-mediated tumor cell deletion.
Robert J Oldham, C Ian Mockridge, +6 authors, Mark S Cragg.
J Immunother Cancer, 2020 Jun 20; 8(1). PMID: 32554613    Free PMC article.
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