Journal Article
. 1996 Mar; 271(5256):1734-6.
doi: 10.1126/science.271.5256.1734.

Enhancement of antitumor immunity by CTLA-4 blockade

D R Leach 1 M F Krummel  J P Allison  
  • PMID: 8596936
  •     1204 citations


One reason for the poor immunogenicity of many tumors may be that they cannot provide signals for CD28-mediated costimulation necessary to fully activate T cells. It has recently become apparent that CTLA-4, a second counterreceptor for the B7 family of costimulatory molecules, is a negative regulator of T cell activation. Here, in vivo administration of antibodies to CTLA-4 resulted in the rejection of tumors, including preestablished tumors. Furthermore, this rejection resulted in immunity to a secondary exposure to tumor cells. These results suggest that blockade of the inhibitory effects of CTLA-4 can allow for, and potentiate, effective immune responses against tumor cells.

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Clin Cancer Res, 2009 May 07; 15(10). PMID: 19417016    Free PMC article.
PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model.
Long Zhang, Thomas F Gajewski, Justin Kline.
Blood, 2009 May 07; 114(8). PMID: 19417208    Free PMC article.
Highly Cited.
Costimulatory and coinhibitory receptors in anti-tumor immunity.
Gregory Driessens, Justin Kline, Thomas F Gajewski.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426219    Free PMC article.
CTLA4 blockade increases Th17 cells in patients with metastatic melanoma.
Erika von Euw, Thinle Chodon, +4 authors, Antoni Ribas.
J Transl Med, 2009 May 22; 7. PMID: 19457253    Free PMC article.
Progress and challenges in the vaccine-based treatment of head and neck cancers.
Aldo Venuti.
J Exp Clin Cancer Res, 2009 May 29; 28. PMID: 19473517    Free PMC article.
Modulating the expression of IFN regulatory factor 8 alters the protumorigenic behavior of CD11b+Gr-1+ myeloid cells.
Trina J Stewart, David J Liewehr, +2 authors, Scott I Abrams.
J Immunol, 2009 Jun 23; 183(1). PMID: 19542426    Free PMC article.
Anti-CTLA4 Antibody Clinical Trials in Melanoma.
Antoni Ribas.
Update Cancer Ther, 2007 Sep 01; 2(3). PMID: 19543441    Free PMC article.
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies.
Karl S Peggs, Sergio A Quezada, +2 authors, James P Allison.
J Exp Med, 2009 Jul 08; 206(8). PMID: 19581407    Free PMC article.
Highly Cited.
Anti-CD40 agonist antibodies: preclinical and clinical experience.
Magi Khalil, Robert H Vonderheide.
Update Cancer Ther, 2007 Jun 01; 2(2). PMID: 19587842    Free PMC article.
Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: serious immune related adverse events across a spectrum of cancer subtypes.
Troy Dillard, Chris G Yedinak, Joshi Alumkal, Maria Fleseriu.
Pituitary, 2009 Jul 30; 13(1). PMID: 19639414
Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion.
Roch Houot, Matthew J Goldstein, +8 authors, Ronald Levy.
Blood, 2009 Jul 31; 114(16). PMID: 19641184    Free PMC article.
Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists.
K S Peggs, S A Quezada, J P Allison.
Clin Exp Immunol, 2009 Aug 08; 157(1). PMID: 19659765    Free PMC article.
Tumor vaccines expressing flt3 ligand synergize with ctla-4 blockade to reject preimplanted tumors.
Michael A Curran, James P Allison.
Cancer Res, 2009 Sep 10; 69(19). PMID: 19738077    Free PMC article.
Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response.
Saba Alzabin, Saiju Pyarajan, +4 authors, Sansana Sawasdikosol.
Cancer Immunol Immunother, 2009 Sep 30; 59(3). PMID: 19787351    Free PMC article.
CTLA-4 +49A>G polymorphism is associated with the risk but not with the progression of colorectal cancer in Chinese.
Peng Qi, Can-ping Ruan, +6 authors, Chun-fang Gao.
Int J Colorectal Dis, 2009 Sep 30; 25(1). PMID: 19787358
Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma.
Antoni Ribas, Begoña Comin-Anduix, +15 authors, Jesus Gomez-Navarro.
Clin Cancer Res, 2009 Oct 01; 15(19). PMID: 19789309    Free PMC article.
Phase I study of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with relapsed and refractory B-cell non-Hodgkin lymphoma.
Stephen M Ansell, Sara A Hurvitz, +10 authors, John M Timmerman.
Clin Cancer Res, 2009 Oct 08; 15(20). PMID: 19808874    Free PMC article.
Highly Cited.
The role of tregs in glioma-mediated immunosuppression: potential target for intervention.
William Humphries, Jun Wei, John H Sampson, Amy B Heimberger.
Neurosurg Clin N Am, 2009 Dec 01; 21(1). PMID: 19944972    Free PMC article.
Inhibitory RNA molecules in immunotherapy for cancer.
Chih-Ping Mao, T-C Wu.
Methods Mol Biol, 2010 Mar 11; 623. PMID: 20217561    Free PMC article.
Monoclonal antibodies: versatile platforms for cancer immunotherapy.
Louis M Weiner, Rishi Surana, Shangzi Wang.
Nat Rev Immunol, 2010 Apr 24; 10(5). PMID: 20414205    Free PMC article.
Highly Cited. Review.
Local release of highly loaded antibodies from functionalized nanoporous support for cancer immunotherapy.
Chenghong Lei, Pu Liu, +7 authors, Karl Erik Hellstrom.
J Am Chem Soc, 2010 May 04; 132(20). PMID: 20433206    Free PMC article.
Inhibitors of B7-CD28 costimulation in urologic malignancies.
R Houston Thompson, Eugene D Kwon, James P Allison.
Immunotherapy, 2009 Jan 01; 1(1). PMID: 20445772    Free PMC article.
Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial.
Bradley C Carthon, Jedd D Wolchok, +8 authors, Padmanee Sharma.
Clin Cancer Res, 2010 May 13; 16(10). PMID: 20460488    Free PMC article.
Highly Cited.
Antigen quality determines the efficiency of antitumor immune responses generated in the absence of regulatory T cells.
A-S Bergot, A Durgeau, +3 authors, D Klatzmann.
Cancer Gene Ther, 2010 May 15; 17(9). PMID: 20467452    Free PMC article.
The biologic importance of tumor-infiltrating lymphocytes.
F Stephen Hodi, Glenn Dranoff.
J Cutan Pathol, 2010 May 28; 37 Suppl 1. PMID: 20482675    Free PMC article.
Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory.
Rong Hu, Constance Lay-Lay Saw, Rong Yu, Ah-Ng Tony Kong.
Antioxid Redox Signal, 2010 May 22; 13(11). PMID: 20486765    Free PMC article.
Modulation of CTLA-4 and GITR for cancer immunotherapy.
Francesca Avogadri, Jianda Yuan, +2 authors, Jedd D Wolchok.
Curr Top Microbiol Immunol, 2010 Jun 22; 344. PMID: 20563707    Free PMC article.
CTLA-4 blockade: therapeutic potential in cancer treatments.
Ahmad A Tarhini, Fatima Iqbal.
Onco Targets Ther, 2010 Jul 10; 3. PMID: 20616954    Free PMC article.
Immune regulatory antibodies: are they the next advance?
Jedd D Wolchok, Arvin S Yang, Jeffrey S Weber.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693841    Free PMC article.
Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy.
Margaret K Callahan, Jedd D Wolchok, James P Allison.
Semin Oncol, 2010 Nov 16; 37(5). PMID: 21074063    Free PMC article.
Extended dose ipilimumab with a peptide vaccine: immune correlates associated with clinical benefit in patients with resected high-risk stage IIIc/IV melanoma.
Amod A Sarnaik, Bin Yu, +9 authors, Jeffrey S Weber.
Clin Cancer Res, 2010 Nov 26; 17(4). PMID: 21106722    Free PMC article.
CTLA-4 exon 1 +49 polymorphism alone and in a haplotype with -318 promoter polymorphism may confer susceptibility to chronic HBV infection in Chinese Han patients.
Shaoqiong Duan, Guoyu Zhang, +11 authors, Fanfan Xing.
Mol Biol Rep, 2010 Dec 17; 38(8). PMID: 21161390
Treatment of cutaneous melanoma: current approaches and future prospects.
Alain P Algazi, Christopher W Soon, Adil I Daud.
Cancer Manag Res, 2010 Dec 29; 2. PMID: 21188111    Free PMC article.
Targeting NKT cells and PD-L1 pathway results in augmented anti-tumor responses in a melanoma model.
Kevin Durgan, Mohamed Ali, Paul Warner, Yvette E Latchman.
Cancer Immunol Immunother, 2011 Jan 18; 60(4). PMID: 21240487    Free PMC article.
Dose-dependent effect of anti-CTLA-4 on survival in sepsis.
Shigeaki Inoue, Lulong Bo, +3 authors, Richard S Hotchkiss.
Shock, 2011 Mar 04; 36(1). PMID: 21368717    Free PMC article.
Expansion of regulatory T cells in aged mice following influenza infection.
Yolanda Williams-Bey, Jiu Jiang, Donna M Murasko.
Mech Ageing Dev, 2011 Mar 19; 132(4). PMID: 21414341    Free PMC article.
Co-inhibitory molecules: Controlling the effectors or controlling the controllers?
Govindarajan Thangavelu, Christa Smolarchuk, Colin C Anderson.
Self Nonself, 2011 Apr 14; 1(2). PMID: 21487510    Free PMC article.
Immunosuppressive tumor microenvironment in cervical cancer patients.
Sytse J Piersma.
Cancer Microenviron, 2011 Jun 01; 4(3). PMID: 21626415    Free PMC article.
Vernon K Sondak, Keiran S M Smalley, +2 authors, Peter Kirkpatrick.
Nat Rev Drug Discov, 2011 Jun 02; 10(6). PMID: 21629286
Immuno-therapy with anti-CTLA4 antibodies in tolerized and non-tolerized mouse tumor models.
Jonas Persson, Ines Beyer, +4 authors, André Lieber.
PLoS One, 2011 Jul 23; 6(7). PMID: 21779410    Free PMC article.
Regulatory T cell: a protection for tumour cells.
Yi Wang, Yushui Ma, +4 authors, Xizhong Shen.
J Cell Mol Med, 2011 Sep 08; 16(3). PMID: 21895966    Free PMC article.
Ipilimumab: an anti-CTLA-4 antibody for metastatic melanoma.
Evan J Lipson, Charles G Drake.
Clin Cancer Res, 2011 Sep 09; 17(22). PMID: 21900389    Free PMC article.
Highly Cited. Review.
Cell-specific aptamers as emerging therapeutics.
Cindy Meyer, Ulrich Hahn, Andrea Rentmeister.
J Nucleic Acids, 2011 Sep 10; 2011. PMID: 21904667    Free PMC article.
Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma.
Adam J Bograd, Kei Suzuki, +4 authors, Prasad S Adusumilli.
Cancer Immunol Immunother, 2011 Sep 14; 60(11). PMID: 21913025    Free PMC article.
Temporal transcriptome changes induced by MDV in Marek's disease-resistant and -susceptible inbred chickens.
Ying Yu, Juan Luo, +6 authors, Jiuzhou Song.
BMC Genomics, 2011 Oct 14; 12. PMID: 21992110    Free PMC article.
Science gone translational: the OX40 agonist story.
Andrew D Weinberg, Nicholas P Morris, +2 authors, Brendan D Curti.
Immunol Rev, 2011 Oct 25; 244(1). PMID: 22017441    Free PMC article.
Novel cancer immunotherapy agents with survival benefit: recent successes and next steps.
Padmanee Sharma, Klaus Wagner, Jedd D Wolchok, James P Allison.
Nat Rev Cancer, 2011 Oct 25; 11(11). PMID: 22020206    Free PMC article.
Highly Cited. Review.
Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells.
Scott K Pruitt, David Boczkowski, +5 authors, Smita Nair.
Eur J Immunol, 2011 Oct 27; 41(12). PMID: 22028176    Free PMC article.
Cancer immunotherapy comes of age.
Suzanne L Topalian, George J Weiner, Drew M Pardoll.
J Clin Oncol, 2011 Nov 02; 29(36). PMID: 22042955    Free PMC article.
Highly Cited. Review.
Blockade of cytotoxic T-lymphocyte antigen-4 as a new therapeutic approach for advanced melanoma.
Xiang-Yang Wang, Daming Zuo, Devanand Sarkar, Paul B Fisher.
Expert Opin Pharmacother, 2011 Nov 15; 12(17). PMID: 22077831    Free PMC article.
Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy.
Rebecca Waitz, Stephen B Solomon, +4 authors, James P Allison.
Cancer Res, 2011 Nov 24; 72(2). PMID: 22108823    Free PMC article.
Trypanosoma cruzi as an effective cancer antigen delivery vector.
Caroline Junqueira, Luara I Santos, +9 authors, Ricardo T Gazzinelli.
Proc Natl Acad Sci U S A, 2011 Nov 25; 108(49). PMID: 22114198    Free PMC article.
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.
Lucy S K Walker, David M Sansom.
Nat Rev Immunol, 2011 Nov 26; 11(12). PMID: 22116087
Highly Cited.
Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity.
Sue M Liu, Andrew P R Sutherland, +7 authors, Vijay K Kuchroo.
J Immunol, 2011 Nov 30; 188(1). PMID: 22124121    Free PMC article.
Immune microenvironment in colorectal cancer: a new hallmark to change old paradigms.
Luis de la Cruz-Merino, Fernando Henao Carrasco, +4 authors, Enrique Grande Pulido.
Clin Dev Immunol, 2011 Dec 14; 2011. PMID: 22162710    Free PMC article.
Ipilimumab and cancer immunotherapy: a new hope for advanced stage melanoma.
Matthew Mansh.
Yale J Biol Med, 2011 Dec 20; 84(4). PMID: 22180676    Free PMC article.
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
Seng-Ryong Woo, Meghan E Turnis, +18 authors, Dario A A Vignali.
Cancer Res, 2011 Dec 22; 72(4). PMID: 22186141    Free PMC article.
Highly Cited.
Tumor evasion from T cell surveillance.
Katrin Töpfer, Stefanie Kempe, +5 authors, Achim Temme.
J Biomed Biotechnol, 2011 Dec 23; 2011. PMID: 22190859    Free PMC article.
Cancer immunotherapy comes of age.
Ira Mellman, George Coukos, Glenn Dranoff.
Nature, 2011 Dec 24; 480(7378). PMID: 22193102    Free PMC article.
Highly Cited. Review.
Use of anti-cancer drugs, mitocans, to enhance the immune responses against tumors.
T Hahn, M J Polanczyk, +3 authors, S J Ralph.
Curr Pharm Biotechnol, 2011 Dec 29; 14(3). PMID: 22201597    Free PMC article.
Phase I trial of tremelimumab in combination with short-term androgen deprivation in patients with PSA-recurrent prostate cancer.
Douglas G McNeel, Heath A Smith, +4 authors, Glenn Liu.
Cancer Immunol Immunother, 2012 Jan 03; 61(7). PMID: 22210552    Free PMC article.
Cancer immunotherapy.
Thomas F Gajewski.
Mol Oncol, 2012 Jan 18; 6(2). PMID: 22248437    Free PMC article.
Novel treatments for metastatic cutaneous melanoma and the management of emergent toxicities.
Charlotte Lemech, Hendrik-Tobias Arkenau.
Clin Med Insights Oncol, 2012 Jan 19; 6. PMID: 22253555    Free PMC article.
Immunotherapy earns its spot in the ranks of cancer therapy.
Drew Pardoll, Charles Drake.
J Exp Med, 2012 Feb 15; 209(2). PMID: 22330682    Free PMC article.
The monoclonal antibody to cytotoxic T lymphocyte antigen 4, ipilimumab, in the treatment of melanoma.
Claire Verschraegen.
Cancer Manag Res, 2012 Feb 22; 4. PMID: 22346364    Free PMC article.
Unmasking the immune recognition of prostate cancer with CTLA4 blockade.
Serena S Kwek, Edward Cha, Lawrence Fong.
Nat Rev Cancer, 2012 Mar 02; 12(4). PMID: 22378189    Free PMC article.
Translatability scoring in drug development: eight case studies.
Alexandra Wendler, Martin Wehling.
J Transl Med, 2012 Mar 09; 10. PMID: 22397594    Free PMC article.
Ipilimumab: its potential in non-small cell lung cancer.
Pascale Tomasini, Nataliya Khobta, Laurent Greillier, Fabrice Barlesi.
Ther Adv Med Oncol, 2012 Mar 17; 4(2). PMID: 22423263    Free PMC article.
The blockade of immune checkpoints in cancer immunotherapy.
Drew M Pardoll.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437870    Free PMC article.
Highly Cited. Review.
Antibody therapy of cancer.
Andrew M Scott, Jedd D Wolchok, Lloyd J Old.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437872
Highly Cited. Review.
Targeting immune checkpoints: releasing the restraints on anti-tumor immunity for patients with melanoma.
Michael A Postow, James Harding, Jedd D Wolchok.
Cancer J, 2012 Mar 29; 18(2). PMID: 22453017    Free PMC article.
From genes to drugs: targeted strategies for melanoma.
Keith T Flaherty, F Stephen Hodi, David E Fisher.
Nat Rev Cancer, 2012 Apr 06; 12(5). PMID: 22475929
Highly Cited. Review.
Regulatory T cells in human ovarian cancer.
Dong-Jun Peng, Rebecca Liu, Weiping Zou.
J Oncol, 2012 Apr 07; 2012. PMID: 22481922    Free PMC article.
Therapeutic antibodies against cancer.
Mark J Adler, Dimiter S Dimitrov.
Hematol Oncol Clin North Am, 2012 Apr 24; 26(3). PMID: 22520975    Free PMC article.
T-regulatory cells: key players in tumor immune escape and angiogenesis.
Andrea Facciabene, Gregory T Motz, George Coukos.
Cancer Res, 2012 May 03; 72(9). PMID: 22549946    Free PMC article.
Highly Cited. Review.
Prostate cancer: combination of vaccine plus ipilimumab--safety and toxicity.
Padmanee Sharma, Christopher Logothetis.
Nat Rev Urol, 2012 May 09; 9(6). PMID: 22565371
State of the science: an update on renal cell carcinoma.
Eric Jonasch, P Andrew Futreal, +13 authors, W Kimryn Rathmell.
Mol Cancer Res, 2012 May 29; 10(7). PMID: 22638109    Free PMC article.
Cutting edge in medical management of cutaneous oncology.
Kim Chong, Adil Daud, +2 authors, UCSF High Risk Skin Cancer Program.
Semin Cutan Med Surg, 2012 May 30; 31(2). PMID: 22640435    Free PMC article.
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L Topalian, F Stephen Hodi, +27 authors, Mario Sznol.
N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658127    Free PMC article.
Highly Cited.
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.
Julie R Brahmer, Scott S Tykodi, +23 authors, Jon M Wigginton.
N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658128    Free PMC article.
Highly Cited.
CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection.
Rebecca Waitz, Marcella Fassò, James P Allison.
Oncoimmunology, 2012 Jul 04; 1(4). PMID: 22754781    Free PMC article.
Novel anti-melanoma immunotherapies: disarming tumor escape mechanisms.
Sivan Sapoznik, Ohad Hammer, +4 authors, Gal Markel.
Clin Dev Immunol, 2012 Jul 11; 2012. PMID: 22778766    Free PMC article.
Modeling and predicting clinical efficacy for drugs targeting the tumor milieu.
Mallika Singh, Napoleone Ferrara.
Nat Biotechnol, 2012 Jul 12; 30(7). PMID: 22781694
Biomarkers on melanoma patient T cells associated with ipilimumab treatment.
Wenshi Wang, Daohai Yu, +6 authors, Jeffrey S Weber.
J Transl Med, 2012 Jul 14; 10. PMID: 22788688    Free PMC article.
NFAT1 supports tumor-induced anergy of CD4(+) T cells.
Brian T Abe, Daniel S Shin, Enric Mocholi, Fernando Macian.
Cancer Res, 2012 Aug 07; 72(18). PMID: 22865456    Free PMC article.
Introduction to monoclonal antibodies.
Jean-Pierre Mach.
Cancer Immun, 2012 Aug 17; 12. PMID: 22896756    Free PMC article.
Monoclonal antibodies in cancer therapy.
Andrew M Scott, James P Allison, Jedd D Wolchok.
Cancer Immun, 2012 Aug 17; 12. PMID: 22896759    Free PMC article.
Highly Cited. Review.
Lung cancer: a classic example of tumor escape and progression while providing opportunities for immunological intervention.
Martin R Jadus, Josephine Natividad, +6 authors, Maria G Dacosta-Iyer.
Clin Dev Immunol, 2012 Aug 18; 2012. PMID: 22899945    Free PMC article.
Ipilimumab pharmacotherapy in patients with metastatic melanoma.
Joanne M Jeter, Lee D Cranmer, Evan M Hersh.
Clin Med Insights Oncol, 2012 Aug 21; 6. PMID: 22904648    Free PMC article.
Regulatory T cells in radiotherapeutic responses.
Dörthe Schaue, Michael W Xie, Josephine A Ratikan, William H McBride.
Front Oncol, 2012 Aug 23; 2. PMID: 22912933    Free PMC article.
Therese Liechtenstein, Ines Dufait, +2 authors, David Escors.
Immunol Endocr Metab Agents Med Chem, 2012 Sep 05; 12(3). PMID: 22945252    Free PMC article.
Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects.
Maria Grazia Ruocco, Karsten A Pilones, +7 authors, Sandra Demaria.
J Clin Invest, 2012 Sep 05; 122(10). PMID: 22945631    Free PMC article.
Highly Cited.
Diversity of antigen-specific responses induced in vivo with CTLA-4 blockade in prostate cancer patients.
Serena S Kwek, Vinh Dao, +5 authors, Lawrence Fong.
J Immunol, 2012 Sep 08; 189(7). PMID: 22956585    Free PMC article.
Advances in the development of cancer immunotherapies.
Jianjun Gao, Chantale Bernatchez, +2 authors, Patrick Hwu.
Trends Immunol, 2012 Oct 04; 34(2). PMID: 23031830    Free PMC article.
T cell coinhibition and immunotherapy in human breast cancer.
Murali Janakiram, Yael M Abadi, Joseph A Sparano, Xingxing Zang.
Discov Med, 2012 Nov 02; 14(77). PMID: 23114578    Free PMC article.
CTLA-4-Tg/CD-28-KO Mice Exhibit Reduced T Cell Proliferation in vivo Compared to CD-28-KO Mice in a Graft-versus-host Disease Model.
Jong-Sun Yoo, Yun-Jung Lee, +2 authors, Kwang Woo Hwang.
Korean J Physiol Pharmacol, 2012 Nov 03; 16(5). PMID: 23118560    Free PMC article.
Immunology beats cancer: a blueprint for successful translation.
Drew M Pardoll.
Nat Immunol, 2012 Nov 20; 13(12). PMID: 23160205    Free PMC article.
Durable adoptive immunotherapy for leukemia produced by manipulation of multiple regulatory pathways of CD8+ T-cell tolerance.
Melissa M Berrien-Elliott, Stephanie R Jackson, +6 authors, Ryan M Teague.
Cancer Res, 2012 Nov 29; 73(2). PMID: 23188506    Free PMC article.
Immunotherapies: the blockade of inhibitory signals.
Yan-Ling Wu, Jing Liang, +2 authors, Hiroshi Sugiyama.
Int J Biol Sci, 2012 Dec 01; 8(10). PMID: 23197939    Free PMC article.
Suppression, subversion and escape: the role of regulatory T cells in cancer progression.
K Oleinika, R J Nibbs, G J Graham, A R Fraser.
Clin Exp Immunol, 2012 Dec 04; 171(1). PMID: 23199321    Free PMC article.
Comparative antitumor effect of preventive versus therapeutic vaccines employing B16 melanoma cells genetically modified to express GM-CSF and B7.2 in a murine model.
Antonio Miguel, María José Herrero, +4 authors, Salvador F Aliño.
Toxins (Basel), 2012 Dec 04; 4(11). PMID: 23202306    Free PMC article.
Immunosuppressive effect of regulatory T lymphocytes in lung cancer, with special reference to their effects on the induction of autologous tumor-specific cytotoxic T lymphocytes.
Yoshiki Shigematsu, Takeshi Hanagiri, +8 authors, Fumihiro Tanaka.
Oncol Lett, 2012 Dec 04; 4(4). PMID: 23205074    Free PMC article.
Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer.
Harald von Boehmer, Carolin Daniel.
Nat Rev Drug Discov, 2013 Jan 01; 12(1). PMID: 23274471
Highly Cited. Review.
Molecular control of steady-state dendritic cell maturation and immune homeostasis.
Gianna Elena Hammer, Averil Ma.
Annu Rev Immunol, 2013 Jan 22; 31. PMID: 23330953    Free PMC article.
Advances in targeting cell surface signalling molecules for immune modulation.
Sheng Yao, Yuwen Zhu, Lieping Chen.
Nat Rev Drug Discov, 2013 Feb 02; 12(2). PMID: 23370250    Free PMC article.
Highly Cited. Review.
CTLA-4 blockade in tumor models: an overview of preclinical and translational research.
Joseph F Grosso, Maria N Jure-Kunkel.
Cancer Immun, 2013 Feb 08; 13. PMID: 23390376    Free PMC article.
Highly Cited. Review.
Immunomodulatory therapy for melanoma: ipilimumab and beyond.
Margaret K Callahan, Michael A Postow, Jedd D Wolchok.
Clin Dermatol, 2013 Feb 27; 31(2). PMID: 23438382    Free PMC article.
The nature of activatory and tolerogenic dendritic cell-derived signal II.
Ghaith Bakdash, Simone P Sittig, +2 authors, I Jolanda M de Vries.
Front Immunol, 2013 Mar 02; 4. PMID: 23450201    Free PMC article.
Agonist antibodies to TNFR molecules that costimulate T and NK cells.
Ignacio Melero, Daniel Hirschhorn-Cymerman, +2 authors, Jedd D Wolchok.
Clin Cancer Res, 2013 Mar 06; 19(5). PMID: 23460535    Free PMC article.
Highly Cited.
Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer.
S A Quezada, K S Peggs.
Br J Cancer, 2013 Mar 21; 108(8). PMID: 23511566    Free PMC article.
Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study.
S F Slovin, C S Higano, +8 authors, T M Beer.
Ann Oncol, 2013 Mar 29; 24(7). PMID: 23535954    Free PMC article.
Highly Cited.
Long-lasting complete regression of established mouse tumors by counteracting Th2 inflammation.
Min Dai, Huafeng Wei, +5 authors, Karl Erik Hellstrom.
J Immunother, 2013 Apr 23; 36(4). PMID: 23603859    Free PMC article.
At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy.
Andrew M Intlekofer, Craig B Thompson.
J Leukoc Biol, 2013 Apr 30; 94(1). PMID: 23625198    Free PMC article.
Highly Cited. Review.
The engagement of CTLA-4 on primary melanoma cell lines induces antibody-dependent cellular cytotoxicity and TNF-α production.
Stefania Laurent, Paola Queirolo, +15 authors, Maria Pia Pistillo.
J Transl Med, 2013 May 03; 11. PMID: 23634660    Free PMC article.
T-cell tolerance in cancer.
Roza Nurieva, Junmei Wang, Anupama Sahoo.
Immunotherapy, 2013 May 04; 5(5). PMID: 23638746    Free PMC article.
Immunomodulatory monoclonal antibodies combined with peptide vaccination provide potent immunotherapy in an aggressive murine neuroblastoma model.
Emily L Williams, Stuart N Dunn, +4 authors, Juliet C Gray.
Clin Cancer Res, 2013 May 08; 19(13). PMID: 23649004    Free PMC article.
At the bedside: CTLA-4- and PD-1-blocking antibodies in cancer immunotherapy.
Margaret K Callahan, Jedd D Wolchok.
J Leukoc Biol, 2013 May 15; 94(1). PMID: 23667165    Free PMC article.
Highly Cited. Review.
Ipilimumab, vemurafenib, dabrafenib, and trametinib: synergistic competitors in the clinical management of BRAF mutant malignant melanoma.
Jason J Luke, F Stephen Hodi.
Oncologist, 2013 May 28; 18(6). PMID: 23709751    Free PMC article.
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.
Kipp Weiskopf, Aaron M Ring, +8 authors, K Christopher Garcia.
Science, 2013 Jun 01; 341(6141). PMID: 23722425    Free PMC article.
Highly Cited.
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma.
Omid Hamid, Caroline Robert, +23 authors, Antoni Ribas.
N Engl J Med, 2013 Jun 04; 369(2). PMID: 23724846    Free PMC article.
Highly Cited.
Depleting tumor-specific Tregs at a single site eradicates disseminated tumors.
Aurélien Marabelle, Holbrook Kohrt, +13 authors, Ronald Levy.
J Clin Invest, 2013 Jun 04; 123(6). PMID: 23728179    Free PMC article.
Highly Cited.
Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4.
Rikke B Holmgaard, Dmitriy Zamarin, +2 authors, James P Allison.
J Exp Med, 2013 Jun 12; 210(7). PMID: 23752227    Free PMC article.
Highly Cited.
Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma.
Jedd D Wolchok, F Stephen Hodi, +9 authors, Alan J Korman.
Ann N Y Acad Sci, 2013 Jun 19; 1291. PMID: 23772560    Free PMC article.
Highly Cited. Review.
An enhanced heterologous virus-like particle for human papillomavirus type 16 tumour immunotherapy.
Khairunadwa Jemon, Vivienne Young, +5 authors, Merilyn Hibma.
PLoS One, 2013 Jun 27; 8(6). PMID: 23799135    Free PMC article.
Immunosuppressive microenvironment in neuroblastoma.
Vito Pistoia, Fabio Morandi, +3 authors, Lizzia Raffaghello.
Front Oncol, 2013 Jun 28; 3. PMID: 23805414    Free PMC article.
Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.
Christopher J Nirschl, Charles G Drake.
Clin Cancer Res, 2013 Jul 23; 19(18). PMID: 23868869    Free PMC article.
Highly Cited. Review.
Therapeutic cancer vaccines: past, present, and future.
Chunqing Guo, Masoud H Manjili, +3 authors, Xiang-Yang Wang.
Adv Cancer Res, 2013 Jul 23; 119. PMID: 23870514    Free PMC article.
Highly Cited. Review.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies.
Yannick Bulliard, Rose Jolicoeur, +6 authors, Jennifer L Brogdon.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897982    Free PMC article.
Highly Cited.
Correlation between B7-H3 expression and matrix metalloproteinases 2 expression in pancreatic cancer.
Lihua Xu, Xiangmin Ding, Huo Tan, Jianjun Qian.
Cancer Cell Int, 2013 Aug 21; 13(1). PMID: 23947693    Free PMC article.
Use of ipilimumab in the treatment of melanoma.
Utkarsh H Acharya, Joanne M Jeter.
Clin Pharmacol, 2013 Oct 12; 5(Suppl 1). PMID: 24113540    Free PMC article.
Differential CTLA-4 expression in human CD4+ versus CD8+ T cells is associated with increased NFAT1 and inhibition of CD4+ proliferation.
D V Chan, H M Gibson, +4 authors, H K Wong.
Genes Immun, 2013 Nov 01; 15(1). PMID: 24173147    Free PMC article.
Anti-cytotoxic T lymphocyte antigen-4 antibodies in melanoma.
Giulio Tosti, Emilia Cocorocchio, Elisabetta Pennacchioli.
Clin Cosmet Investig Dermatol, 2013 Nov 10; 6. PMID: 24204168    Free PMC article.
Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer.
Charles G Drake, Evan J Lipson, Julie R Brahmer.
Nat Rev Clin Oncol, 2013 Nov 20; 11(1). PMID: 24247168    Free PMC article.
Highly Cited. Review.
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer.
Christine Feig, James O Jones, +12 authors, Douglas T Fearon.
Proc Natl Acad Sci U S A, 2013 Nov 28; 110(50). PMID: 24277834    Free PMC article.
Highly Cited.
Recent developments in the treatment of renal cell carcinoma.
Janice P Dutcher.
Ther Adv Urol, 2013 Dec 03; 5(6). PMID: 24294292    Free PMC article.
Association between cytotoxic T lymphocyte antigen-4 +49A/G, -1722T/C, and -1661A/G polymorphisms and cancer risk: a meta-analysis.
Rui Geng, Fanglong Song, +5 authors, Weimin Fan.
Tumour Biol, 2013 Dec 07; 35(4). PMID: 24307627
Cancer immunotherapy: are we there yet?
Zihai Li, Lieping Chen, Mark P Rubinstein.
Exp Hematol Oncol, 2013 Dec 12; 2(1). PMID: 24326015    Free PMC article.
Clinical Implications of Co-Inhibitory Molecule Expression in the Tumor Microenvironment for DC Vaccination: A Game of Stop and Go.
Angela Vasaturo, Stefania Di Blasio, +4 authors, Stanleyson V Hato.
Front Immunol, 2013 Dec 19; 4. PMID: 24348481    Free PMC article.
Association between CTLA-4 60G/A and -1661A/G polymorphisms and the risk of cancers: a meta-analysis.
Qing Yan, Pin Chen, +2 authors, Aihua Gu.
PLoS One, 2014 Jan 01; 8(12). PMID: 24376736    Free PMC article.
BRAF and MEK gene rearrangements in melanoma: implications for targeted therapy.
Pedro Madureira, Ramon Andrade de Mello.
Mol Diagn Ther, 2014 Jan 10; 18(3). PMID: 24403169
Paradoxical activation of T cells via augmented ERK signaling mediated by a RAF inhibitor.
Margaret K Callahan, Gregg Masters, +13 authors, Jedd D Wolchok.
Cancer Immunol Res, 2014 Jan 15; 2(1). PMID: 24416731    Free PMC article.
Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer.
David C Binder, Boris Engels, +11 authors, Hans Schreiber.
Cancer Immunol Res, 2014 Jan 24; 1(2). PMID: 24455752    Free PMC article.
Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression.
Shannon K Oda, Pamela Strauch, +5 authors, Raul M Torres.
Cancer Immunol Res, 2014 Jan 24; 1(4). PMID: 24455753    Free PMC article.
In vivo discovery of immunotherapy targets in the tumour microenvironment.
Penghui Zhou, Donald R Shaffer, +17 authors, Kai W Wucherpfennig.
Nature, 2014 Jan 31; 506(7486). PMID: 24476824    Free PMC article.
Highly Cited.
PD-L1 Expression in Clear Cell Renal Cell Carcinoma: An Analysis of Nephrectomy and Sites of Metastases.
L B Jilaveanu, B Shuch, +5 authors, H M Kluger.
J Cancer, 2014 Feb 25; 5(3). PMID: 24563671    Free PMC article.
Immune checkpoint blockade: the hope for immunotherapy as a treatment of lung cancer?
Julie R Brahmer.
Semin Oncol, 2014 Feb 26; 41(1). PMID: 24565586    Free PMC article.
Local hyperthermia treatment of tumors induces CD8(+) T cell-mediated resistance against distal and secondary tumors.
Seiko Toraya-Brown, Mee Rie Sheen, +7 authors, Steven Fiering.
Nanomedicine, 2014 Feb 26; 10(6). PMID: 24566274    Free PMC article.
Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an "innocent bystander".
Lucia Gelao, Carmen Criscitiello, +2 authors, Giuseppe Curigliano.
Toxins (Basel), 2014 Mar 07; 6(3). PMID: 24594636    Free PMC article.
Efficacy and safety of ipilimumab therapy in patients with metastatic melanoma: a retrospective multicenter analysis.
Katarzyna Wiater, Tomasz Switaj, +7 authors, Piotr Rutkowski.
Contemp Oncol (Pozn), 2013 Jan 01; 17(3). PMID: 24596511    Free PMC article.
Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy.
Dmitriy Zamarin, Rikke B Holmgaard, +6 authors, James P Allison.
Sci Transl Med, 2014 Mar 07; 6(226). PMID: 24598590    Free PMC article.
Highly Cited.
Armed therapeutic viruses - a disruptive therapy on the horizon of cancer immunotherapy.
Maxine Bauzon, Terry Hermiston.
Front Immunol, 2014 Mar 08; 5. PMID: 24605114    Free PMC article.
Host immune response to infection and cancer: unexpected commonalities.
Romina S Goldszmid, Amiran Dzutsev, Giorgio Trinchieri.
Cell Host Microbe, 2014 Mar 19; 15(3). PMID: 24629336    Free PMC article.
Tumour immunogenicity, antigen presentation and immunological barriers in cancer immunotherapy.
David Escors.
New J Sci, 2014 Mar 19; 2014. PMID: 24634791    Free PMC article.
Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model.
Raffaella Iannone, Lucio Miele, +2 authors, Silvana Morello.
Am J Cancer Res, 2014 Mar 25; 4(2). PMID: 24660106    Free PMC article.
Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy.
Xiaozhou Fan, Sergio A Quezada, +2 authors, James P Allison.
J Exp Med, 2014 Apr 02; 211(4). PMID: 24687957    Free PMC article.
Highly Cited.
Unmet needs in squamous cell carcinoma of the lung: potential role for immunotherapy.
Thomas E Stinchcombe.
Med Oncol, 2014 Apr 22; 31(5). PMID: 24748366    Free PMC article.
Apoptosis-regulated low-avidity cancer-specific CD8(+) T cells can be rescued to eliminate HER2/neu-expressing tumors by costimulatory agonists in tolerized mice.
Chelsea M Black, Todd D Armstrong, Elizabeth M Jaffee.
Cancer Immunol Res, 2014 Apr 26; 2(4). PMID: 24764578    Free PMC article.
Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti-CTLA-4 therapy.
Derek Ng Tang, Yu Shen, +5 authors, Padmanee Sharma.
Cancer Immunol Res, 2014 Apr 30; 1(4). PMID: 24777852    Free PMC article.
Highly Cited.
CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy.
Hong Chen, Tihui Fu, +7 authors, Padmanee Sharma.
Cancer Immunol Res, 2014 Apr 30; 2(2). PMID: 24778280    Free PMC article.
Paradigm Shift in Dendritic Cell-Based Immunotherapy: From in vitro Generated Monocyte-Derived DCs to Naturally Circulating DC Subsets.
Florian Wimmers, Gerty Schreibelt, +2 authors, I Jolanda M De Vries.
Front Immunol, 2014 May 02; 5. PMID: 24782868    Free PMC article.
A novel pancreatic β-cell targeting bispecific-antibody (BsAb) can prevent the development of type 1 diabetes in NOD mice.
Palash Bhattacharya, Jilao Fan, +5 authors, Bellur S Prabhakar.
Clin Immunol, 2014 May 06; 153(1). PMID: 24792135    Free PMC article.
Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients.
Edward Cha, Mark Klinger, +4 authors, Lawrence Fong.
Sci Transl Med, 2014 May 30; 6(238). PMID: 24871131    Free PMC article.
Highly Cited.
Blocking immunosuppressive checkpoints for glioma therapy: the more the Merrier!
Maria G Castro, Gregory J Baker, Pedro R Lowenstein.
Clin Cancer Res, 2014 Jun 01; 20(20). PMID: 24879798    Free PMC article.
CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells.
Andreas Herrmann, Saul J Priceman, +10 authors, Hua Yu.
J Clin Invest, 2014 Jun 04; 124(7). PMID: 24892807    Free PMC article.
Opportunistic Autoimmune Disorders Potentiated by Immune-Checkpoint Inhibitors Anti-CTLA-4 and Anti-PD-1.
Yi-Chi M Kong, Jeffrey C Flynn.
Front Immunol, 2014 Jun 07; 5. PMID: 24904570    Free PMC article.
Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment.
Mary B Mockler, Melissa J Conroy, Joanne Lysaght.
Front Oncol, 2014 Jun 07; 4. PMID: 24904823    Free PMC article.
Current trends in glioblastoma multiforme treatment: radiation therapy and immune checkpoint inhibitors.
Sarah Nicholas, Dimitris Mathios, +3 authors, Michael Lim.
Brain Tumor Res Treat, 2013 Apr 01; 1(1). PMID: 24904882    Free PMC article.
Induced regulatory T cells in inhibitory microenvironments created by cancer.
Theresa L Whiteside.
Expert Opin Biol Ther, 2014 Jun 18; 14(10). PMID: 24934899    Free PMC article.
Vemurafenib: an evidence-based review of its clinical utility in the treatment of metastatic melanoma.
Abhisek Swaika, Jennifer A Crozier, Richard W Joseph.
Drug Des Devel Ther, 2014 Jun 27; 8. PMID: 24966667    Free PMC article.
Tackling the cancer stem cells - what challenges do they pose?
Diwakar R Pattabiraman, Robert A Weinberg.
Nat Rev Drug Discov, 2014 Jul 02; 13(7). PMID: 24981363    Free PMC article.
Highly Cited. Review.
Ipilimumab augments antitumor activity of bispecific antibody-armed T cells.
Hiroshi Yano, Archana Thakur, +3 authors, Lawrence G Lum.
J Transl Med, 2014 Jul 11; 12. PMID: 25008236    Free PMC article.
Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model.
Zineb Belcaid, Jillian A Phallen, +17 authors, Michael Lim.
PLoS One, 2014 Jul 12; 9(7). PMID: 25013914    Free PMC article.
Highly Cited.
Tumor-specific oncolytic adenoviruses expressing granulocyte macrophage colony-stimulating factor or anti-CTLA4 antibody for the treatment of cancers.
T Du, G Shi, +5 authors, D C Yu.
Cancer Gene Ther, 2014 Jul 19; 21(8). PMID: 25034886
PD-1 as an emerging therapeutic target in renal cell carcinoma: current evidence.
Scott S Tykodi.
Onco Targets Ther, 2014 Aug 13; 7. PMID: 25114573    Free PMC article.
Curing mice with large tumors by locally delivering combinations of immunomodulatory antibodies.
Min Dai, Yuen Yee Yip, Ingegerd Hellstrom, Karl Erik Hellstrom.
Clin Cancer Res, 2014 Aug 22; 21(5). PMID: 25142145    Free PMC article.
No longer an untreatable disease: how targeted and immunotherapies have changed the management of melanoma patients.
Maria Romina Girotti, Grazia Saturno, Paul Lorigan, Richard Marais.
Mol Oncol, 2014 Sep 03; 8(6). PMID: 25178978    Free PMC article.
Combining radiation and immunotherapy: a new systemic therapy for solid tumors?
Chad Tang, Xiaohong Wang, +14 authors, James W Welsh.
Cancer Immunol Res, 2014 Sep 05; 2(9). PMID: 25187273    Free PMC article.
Highly Cited. Review.
Immune checkpoint inhibitors in clinical trials.
Elad Sharon, Howard Streicher, Priscila Goncalves, Helen X Chen.
Chin J Cancer, 2014 Sep 06; 33(9). PMID: 25189716    Free PMC article.
Modeling putative therapeutic implications of exosome exchange between tumor and immune cells.
Mingyang Lu, Bin Huang, +2 authors, Eshel Ben-Jacob.
Proc Natl Acad Sci U S A, 2014 Sep 24; 111(40). PMID: 25246552    Free PMC article.
Immune suppressive effect of cinnamaldehyde due to inhibition of proliferation and induction of apoptosis in immune cells: implications in cancer.
Franziska Roth-Walter, Anna Moskovskich, +6 authors, Erika Jensen-Jarolim.
PLoS One, 2014 Oct 02; 9(10). PMID: 25271635    Free PMC article.
Intratumoral checkpoint subversion as a strategy for minimizing adverse effects: Harvesting the power of TILs without harvesting TILs.
Leah Alabanza, Sacha Gnjatic, Nina Bhardwaj, Joshua Brody.
Oncoimmunology, 2014 Oct 24; 3. PMID: 25339995    Free PMC article.
Victory and defeat in the induction of a therapeutic response through vaccine therapy for human and canine brain tumors: a review of the state of the art.
Michael R Olin, G Elizabeth Pluhar, +3 authors, Christopher L Moertel.
Crit Rev Immunol, 2014 Nov 19; 34(5). PMID: 25404047    Free PMC article.
Drug development: a chance of survival.
Hannah Hoag.
Nature, 2014 Nov 20; 515(7527). PMID: 25407709
Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.
Miranda L Broz, Mikhail Binnewies, +12 authors, Matthew F Krummel.
Cancer Cell, 2014 Dec 03; 26(5). PMID: 25446897    Free PMC article.
Highly Cited.
Immunologic checkpoints in cancer therapy: focus on the programmed death-1 (PD-1) receptor pathway.
Parisa Momtaz, Michael A Postow.
Pharmgenomics Pers Med, 2014 Dec 09; 7. PMID: 25484597    Free PMC article.
Balance and imbalance in the immune system: life on the edge.
Suzanne L Topalian, Arlene H Sharpe.
Immunity, 2014 Dec 18; 41(5). PMID: 25517610    Free PMC article.
Molecularly targeted therapies in non-small-cell lung cancer annual update 2014.
Daniel Morgensztern, Meghan J Campo, +21 authors, Ramaswamy Govindan.
J Thorac Oncol, 2014 Dec 24; 10(1 Suppl 1). PMID: 25535693    Free PMC article.
Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.
Helga Schneider, Christopher E Rudd.
Front Immunol, 2014 Dec 30; 5. PMID: 25538704    Free PMC article.
CD80-CD28 signaling controls the progression of inflammatory colorectal carcinogenesis.
Marco Scarpa, Paola Brun, +13 authors, Carlo Castoro.
Oncotarget, 2015 Jan 18; 6(24). PMID: 25595911    Free PMC article.
Immune Checkpoint Blockade in Cancer Therapy.
Michael A Postow, Margaret K Callahan, Jedd D Wolchok.
J Clin Oncol, 2015 Jan 22; 33(17). PMID: 25605845    Free PMC article.
Highly Cited. Review.
Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma.
Ziming Du, Malak Abedalthagafi, +16 authors, Sandro Santagata.
Oncotarget, 2015 Jan 23; 6(7). PMID: 25609200    Free PMC article.
The mouse NKR-P1B:Clr-b recognition system is a negative regulator of innate immune responses.
Mir Munir A Rahim, Peter Chen, +8 authors, Andrew P Makrigiannis.
Blood, 2015 Jan 24; 125(14). PMID: 25612621    Free PMC article.
CTLA-4 and PD-1 Pathway Blockade: Combinations in the Clinic.
Margaret K Callahan, Michael A Postow, Jedd D Wolchok.
Front Oncol, 2015 Feb 03; 4. PMID: 25642417    Free PMC article.
Highly Cited. Review.
Review of immune-related adverse events in prostate cancer patients treated with ipilimumab: MD Anderson experience.
J Gao, Q He, +6 authors, P Sharma.
Oncogene, 2015 Feb 11; 34(43). PMID: 25659583    Free PMC article.
New and emerging therapeutic options for malignant pleural mesothelioma: review of early clinical trials.
Svetlana Kotova, Raymond M Wong, Robert B Cameron.
Cancer Manag Res, 2015 Feb 12; 7. PMID: 25670913    Free PMC article.
Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma.
Rafael Winograd, Katelyn T Byrne, +8 authors, Robert H Vonderheide.
Cancer Immunol Res, 2015 Feb 14; 3(4). PMID: 25678581    Free PMC article.
Highly Cited.
Glioblastoma stem cells and stem cell-targeting immunotherapies.
Rogelio Esparza, Tej D Azad, +2 authors, Samuel H Cheshier.
J Neurooncol, 2015 Feb 16; 123(3). PMID: 25682090
Combining immunotherapy with oncogene-targeted therapy: a new road for melanoma treatment.
Mariana Aris, María Marcela Barrio.
Front Immunol, 2015 Feb 25; 6. PMID: 25709607    Free PMC article.
Immunotherapy for lung cancer: for whom the bell tolls?
Pedro Madureira, Ramon Andrade de Mello, Alessandro de Vasconcelos, Yan Zhang.
Tumour Biol, 2015 Mar 05; 36(3). PMID: 25736929
The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma.
Pengyuan Yang, Geoffrey J Markowitz, Xiao-Fan Wang.
Natl Sci Rev, 2015 Mar 06; 1(3). PMID: 25741453    Free PMC article.
The role of checkpoints in the treatment of GBM.
Jennifer E Kim, Michael Lim.
J Neurooncol, 2015 Mar 10; 123(3). PMID: 25749875    Free PMC article.
Nivolumab in melanoma: latest evidence and clinical potential.
Douglas B Johnson, Chengwei Peng, Jeffrey A Sosman.
Ther Adv Med Oncol, 2015 Mar 11; 7(2). PMID: 25755682    Free PMC article.
OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal.
Stefanie N Linch, Michael J McNamara, William L Redmond.
Front Oncol, 2015 Mar 13; 5. PMID: 25763356    Free PMC article.
Highly Cited. Review.
Immune approaches to the treatment of breast cancer, around the corner?
Carmen Criscitiello, Angela Esposito, +6 authors, Giuseppe Curigliano.
Breast Cancer Res, 2014 Jan 01; 16(1). PMID: 25774617    Free PMC article.
Immune checkpoint blockade: a common denominator approach to cancer therapy.
Suzanne L Topalian, Charles G Drake, Drew M Pardoll.
Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858804    Free PMC article.
Highly Cited. Review.
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential.
Padmanee Sharma, James P Allison.
Cell, 2015 Apr 11; 161(2). PMID: 25860605    Free PMC article.
Highly Cited. Review.
Ipilimumab and immune-mediated adverse events: a case report of anti-CTLA4 induced ileitis.
Olga Venditti, Delia De Lisi, +9 authors, Daniele Santini.
BMC Cancer, 2015 Apr 18; 15. PMID: 25885696    Free PMC article.
Immune Mechanisms Are Major Players in Cancer.
Karl Erik Hellstrom, Ingegerd Hellstrom.
Clin Cancer Res, 2015 Apr 24; 21(16). PMID: 25904750    Free PMC article.
Checkpoint modulation--A new way to direct the immune system against renal cell carcinoma.
Jens Bedke, Stephan Kruck, +2 authors, Peter J Goebell.
Hum Vaccin Immunother, 2015 Apr 29; 11(5). PMID: 25912622    Free PMC article.
Late onset ipilimumab-induced pericarditis and pericardial effusion: a rare but life threatening complication.
Seongseok Yun, Nicole D Vincelette, +2 authors, Sara Motamed.
Case Rep Oncol Med, 2015 Apr 29; 2015. PMID: 25918658    Free PMC article.
Cancer immunotherapy and immune-related response assessment: The role of radiologists in the new arena of cancer treatment.
Mizuki Nishino, Sree H Tirumani, Nikhil H Ramaiya, F Stephen Hodi.
Eur J Radiol, 2015 May 06; 84(7). PMID: 25937524    Free PMC article.
A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy.
Robert D Leone, Ying-Chun Lo, Jonathan D Powell.
Comput Struct Biotechnol J, 2015 May 06; 13. PMID: 25941561    Free PMC article.
Highly Cited. Review.
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Jun Liu, Ying Yuan, +8 authors, Li Wang.
Proc Natl Acad Sci U S A, 2015 May 13; 112(21). PMID: 25964334    Free PMC article.
Highly Cited.
Preexisting Levels of CD4 T Cells Expressing PD-1 Are Related to Overall Survival in Prostate Cancer Patients Treated with Ipilimumab.
Serena S Kwek, Jera Lewis, +7 authors, Lawrence Fong.
Cancer Immunol Res, 2015 May 15; 3(9). PMID: 25968455    Free PMC article.
Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy.
Keishi Adachi, Koji Tamada.
Cancer Sci, 2015 May 20; 106(8). PMID: 25981182    Free PMC article.
Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia.
Hanna A Knaus, Christopher G Kanakry, Leo Luznik, Ivana Gojo.
Curr Drug Targets, 2015 May 20; 18(3). PMID: 25981611    Free PMC article.
Perforin and granzymes: function, dysfunction and human pathology.
Ilia Voskoboinik, James C Whisstock, Joseph A Trapani.
Nat Rev Immunol, 2015 May 23; 15(6). PMID: 25998963
Highly Cited. Review.
Two heads better than one? Ipilimumab immunotherapy and radiation therapy for melanoma brain metastases.
Kirtesh R Patel, David H Lawson, +5 authors, Mohammad K Khan.
Neuro Oncol, 2015 May 28; 17(10). PMID: 26014049    Free PMC article.
Inhibitory receptors as targets for cancer immunotherapy.
Meghan E Turnis, Lawrence P Andrews, Dario A A Vignali.
Eur J Immunol, 2015 May 29; 45(7). PMID: 26018646    Free PMC article.
Programmed death-1 checkpoint blockade in acute myeloid leukemia.
Alison Sehgal, Theresa L Whiteside, Michael Boyiadzis.
Expert Opin Biol Ther, 2015 Jun 04; 15(8). PMID: 26036819    Free PMC article.
Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy.
Rosa Barreira da Silva, Melissa E Laird, +3 authors, Matthew L Albert.
Nat Immunol, 2015 Jun 16; 16(8). PMID: 26075911
Highly Cited.
Rationale for a Multimodality Strategy to Enhance the Efficacy of Dendritic Cell-Based Cancer Immunotherapy.
Jashodeep Datta, Erik Berk, +3 authors, Brian J Czerniecki.
Front Immunol, 2015 Jun 18; 6. PMID: 26082780    Free PMC article.
Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers.
Luisa Carbognin, Sara Pilotto, +11 authors, Giampaolo Tortora.
PLoS One, 2015 Jun 19; 10(6). PMID: 26086854    Free PMC article.
Highly Cited.
Radiographic Profiling of Immune-Related Adverse Events in Advanced Melanoma Patients Treated with Ipilimumab.
Sree Harsha Tirumani, Nikhil H Ramaiya, +4 authors, Mizuki Nishino.
Cancer Immunol Res, 2015 Jun 24; 3(10). PMID: 26100356    Free PMC article.
Viral Infection of Tumors Overcomes Resistance to PD-1-immunotherapy by Broadening Neoantigenome-directed T-cell Responses.
Norman Woller, Engin Gürlevik, +9 authors, Florian Kühnel.
Mol Ther, 2015 Jun 27; 23(10). PMID: 26112079    Free PMC article.
Highly Cited.
In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment.
Claire Vanpouille-Box, Karsten A Pilones, +2 authors, Sandra Demaria.
Vaccine, 2015 Jul 08; 33(51). PMID: 26148880    Free PMC article.
Clinical Development of Immune Checkpoint Inhibitors.
Ayumu Ito, Shunsuke Kondo, Kohei Tada, Shigehisa Kitano.
Biomed Res Int, 2015 Jul 15; 2015. PMID: 26161407    Free PMC article.
Clinicopathologic analysis of programmed cell death-1 and programmed cell death-ligand 1 and 2 expressions in pulmonary adenocarcinoma: comparison with histology and driver oncogenic alteration status.
Jaemoon Koh, Heounjeong Go, +9 authors, Doo Hyun Chung.
Mod Pathol, 2015 Jul 18; 28(9). PMID: 26183759
Defining Effective Combinations of Immune Checkpoint Blockade and Oncolytic Virotherapy.
Juan J Rojas, Padma Sampath, Weizhou Hou, Steve H Thorne.
Clin Cancer Res, 2015 Jul 19; 21(24). PMID: 26187615    Free PMC article.
Highly Cited.
Editorial: "Cancer Immunotherapy: Lights and Shadows".
María Marcela Barrio, Estrella Mariel Levy, José Mordoh.
Front Immunol, 2015 Jul 29; 6. PMID: 26217342    Free PMC article.
Melanoma: From Incurable Beast to a Curable Bet. The Success of Immunotherapy.
Maria Libera Ascierto, Ignacio Melero, Paolo Antonio Ascierto.
Front Oncol, 2015 Jul 29; 5. PMID: 26217587    Free PMC article.
Immunosuppressive Mechanisms of Malignant Gliomas: Parallels at Non-CNS Sites.
Powell Perng, Michael Lim.
Front Oncol, 2015 Jul 29; 5. PMID: 26217588    Free PMC article.
Associations between CTLA-4 +49 A/G (rs231775) polymorphism and cancer risk: a meta-analysis based on 52 case-control studies.
Lu Wang, Zhiwei Jiang, +3 authors, Lixin Wang.
Int J Clin Exp Med, 2015 Jul 30; 8(5). PMID: 26221222    Free PMC article.
Immunotherapy treatments for small-cell lung cancer: past, present and future.
Matthew Whitehurst, Alberto Chiappori.
Lung Cancer Manag, 2013 Jan 01; 2(6). PMID: 26236401    Free PMC article.
Tumor neoantigens: building a framework for personalized cancer immunotherapy.
Matthew M Gubin, Maxim N Artyomov, Elaine R Mardis, Robert D Schreiber.
J Clin Invest, 2015 Aug 11; 125(9). PMID: 26258412    Free PMC article.
Highly Cited. Review.
Molecular Targeted Intervention for Pancreatic Cancer.
Altaf Mohammed, Naveena B Janakiram, Shubham Pant, Chinthalapally V Rao.
Cancers (Basel), 2015 Aug 13; 7(3). PMID: 26266422    Free PMC article.
Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia.
Nathan A Koonce, Joseph Levy, +6 authors, Robert J Griffin.
PLoS One, 2015 Aug 27; 10(8). PMID: 26308944    Free PMC article.
Strategies for combining immunotherapy with radiation for anticancer therapy.
Steven N Seyedin, Jonathan E Schoenhals, +14 authors, James W Welsh.
Immunotherapy, 2015 Aug 28; 7(9). PMID: 26310908    Free PMC article.
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.
Katherine B Chiappinelli, Pamela L Strissel, +20 authors, Reiner Strick.
Cell, 2015 Sep 01; 162(5). PMID: 26317466    Free PMC article.
Highly Cited.
Cancer immunotherapy: harnessing the immune system to battle cancer.
Yiping Yang.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325031    Free PMC article.
Highly Cited. Review.
Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade.
Elizabeth Buchbinder, F Stephen Hodi.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325034    Free PMC article.
Cancer targeted therapeutics: From molecules to drug delivery vehicles.
Daxing Liu, Debra T Auguste.
J Control Release, 2015 Sep 08; 219. PMID: 26342659    Free PMC article.
Cancer immunotherapy innovator James Allison receives the 2015 Lasker~DeBakey Clinical Medical Research Award.
Jillian H Hurst.
J Clin Invest, 2015 Sep 09; 125(10). PMID: 26345422    Free PMC article.
Immunology and Immunotherapy of Head and Neck Cancer.
Robert L Ferris.
J Clin Oncol, 2015 Sep 10; 33(29). PMID: 26351330    Free PMC article.
Highly Cited. Review.
Several immune escape patterns in non-Hodgkin's lymphomas.
Camille Laurent, Konstantina Charmpi, +7 authors, Jean-Jacques Fournié.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405585    Free PMC article.
Phase II study of the immune-checkpoint inhibitor ipilimumab plus dacarbazine in Japanese patients with previously untreated, unresectable or metastatic melanoma.
N Yamazaki, H Uhara, +8 authors, T Tokudome.
Cancer Chemother Pharmacol, 2015 Sep 27; 76(5). PMID: 26407818    Free PMC article.
Phase II study of ipilimumab monotherapy in Japanese patients with advanced melanoma.
N Yamazaki, Y Kiyohara, +8 authors, T Tokudome.
Cancer Chemother Pharmacol, 2015 Sep 28; 76(5). PMID: 26410424    Free PMC article.
Signaling pathway and dysregulation of PD1 and its ligands in lymphoid malignancies.
Yi Xia, L Jeffrey Medeiros, Ken H Young.
Biochim Biophys Acta, 2015 Oct 04; 1865(1). PMID: 26432723    Free PMC article.
Intellectual property issues of immune checkpoint inhibitors.
Ulrich Storz.
MAbs, 2015 Oct 16; 8(1). PMID: 26466763    Free PMC article.
Concepts and mechanisms underlying chemotherapy induced immunogenic cell death: impact on clinical studies and considerations for combined therapies.
Simon Gebremeskel, Brent Johnston.
Oncotarget, 2015 Oct 22; 6(39). PMID: 26486085    Free PMC article.
Immune checkpoint inhibitors: a new frontier in bladder cancer.
Max Kates, Nikolai A Sopko, +3 authors, Trinity J Bivalacqua.
World J Urol, 2015 Oct 22; 34(1). PMID: 26487055
Immune checkpoints and immunotherapy for colorectal cancer.
Preet Paul Singh, Piyush K Sharma, Gayathri Krishnan, A Craig Lockhart.
Gastroenterol Rep (Oxf), 2015 Oct 30; 3(4). PMID: 26510455    Free PMC article.
Immunomodulation: checkpoint blockade etc.
William T Curry, Michael Lim.
Neuro Oncol, 2015 Oct 31; 17 Suppl 7. PMID: 26516223    Free PMC article.
Novel immunotherapies in lymphoid malignancies.
Connie Lee Batlevi, Eri Matsuki, Renier J Brentjens, Anas Younes.
Nat Rev Clin Oncol, 2015 Nov 04; 13(1). PMID: 26525683    Free PMC article.
Highly Cited. Review.
Phase I Clinical Trial of Ipilimumab in Pediatric Patients with Advanced Solid Tumors.
Melinda S Merchant, Matthew Wright, +9 authors, Crystal L Mackall.
Clin Cancer Res, 2015 Nov 05; 22(6). PMID: 26534966    Free PMC article.
Immune-checkpoint blockade: the springboard for immuno-combination therapy.
A M Ibrahim, Y Wang, N R Lemoine.
Gene Ther, 2015 Nov 06; 22(11). PMID: 26537748
Cancer immunotherapy: Strategies for personalization and combinatorial approaches.
Vishwanath Sathyanarayanan, Sattva S Neelapu.
Mol Oncol, 2015 Nov 10; 9(10). PMID: 26548534    Free PMC article.
CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition.
Elizabeth I Buchbinder, Anupam Desai.
Am J Clin Oncol, 2015 Nov 13; 39(1). PMID: 26558876    Free PMC article.
Highly Cited. Review.
Emerging targets in cancer immunotherapy: beyond CTLA-4 and PD-1.
Amer Assal, Justin Kaner, Gopichand Pendurti, Xingxing Zang.
Immunotherapy, 2015 Nov 17; 7(11). PMID: 26567614    Free PMC article.
Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy.
Anna Śledzińska, Laurie Menger, +2 authors, Sergio A Quezada.
Mol Oncol, 2015 Nov 19; 9(10). PMID: 26578451    Free PMC article.
Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy.
Vinod Vijay Subhash, Mei Shi Yeo, Woei Loon Tan, Wei Peng Yong.
J Immunol Res, 2015 Nov 19; 2015. PMID: 26579545    Free PMC article.
Immunology: Another shot at cancer.
Charles Schmidt.
Nature, 2015 Nov 19; 527(7578). PMID: 26580157
Harnessing the Power of Onco-Immunotherapy with Checkpoint Inhibitors.
Karishma R Rajani, Richard G Vile.
Viruses, 2015 Nov 19; 7(11). PMID: 26580645    Free PMC article.
Nanotechnologies for biomedical science and translational medicine.
James R Heath.
Proc Natl Acad Sci U S A, 2015 Nov 26; 112(47). PMID: 26598663    Free PMC article.
Melanoma: oncogenic drivers and the immune system.
Niki Karachaliou, Sara Pilotto, +10 authors, Rafael Rosell.
Ann Transl Med, 2015 Nov 26; 3(18). PMID: 26605311    Free PMC article.
Current evidence on the cytotoxic T-lymphocyte antigen 4 + 49G > A polymorphism and digestive system cancer risks: a meta-analysis involving 11,923 subjects.
Liu Xiaolei, Yang Baohong, +10 authors, Yu Guohua.
Meta Gene, 2015 Dec 03; 6. PMID: 26629416    Free PMC article.
Clinical relevance of host immunity in breast cancer: from TILs to the clinic.
Peter Savas, Roberto Salgado, +4 authors, Sherene Loi.
Nat Rev Clin Oncol, 2015 Dec 17; 13(4). PMID: 26667975
Highly Cited. Review.
Single-cell analysis tools for drug discovery and development.
James R Heath, Antoni Ribas, Paul S Mischel.
Nat Rev Drug Discov, 2015 Dec 17; 15(3). PMID: 26669673    Free PMC article.
Highly Cited. Review.
CCR 20th Anniversary Commentary: MAPK/ERK Pathway Inhibition in Melanoma-Kinase Inhibition Redux.
Diwakar Davar, John M Kirkwood.
Clin Cancer Res, 2015 Dec 17; 21(24). PMID: 26672083    Free PMC article.
New Strategies in Bladder Cancer: A Second Coming for Immunotherapy.
Ali Ghasemzadeh, Trinity J Bivalacqua, Noah M Hahn, Charles G Drake.
Clin Cancer Res, 2015 Dec 20; 22(4). PMID: 26683632    Free PMC article.
Immune Checkpoint Blockade in Hepatocellular Carcinoma.
M Kudo.
Liver Cancer, 2016 Jan 07; 4(4). PMID: 26732472    Free PMC article.
Low-Intensity Focused Ultrasound Induces Reversal of Tumor-Induced T Cell Tolerance and Prevents Immune Escape.
Sanmay Bandyopadhyay, Thomas J Quinn, +5 authors, Chandan Guha.
J Immunol, 2016 Jan 13; 196(4). PMID: 26755821    Free PMC article.
Large molecular systems landscape uncovers T cell trapping in human skin cancer.
Reyk Hillert, Anne Gieseler, +5 authors, Walter Schubert.
Sci Rep, 2016 Jan 14; 6. PMID: 26757895    Free PMC article.
Cancer stem cells and immunoresistance: clinical implications and solutions.
Jordi Codony-Servat, Rafael Rosell.
Transl Lung Cancer Res, 2016 Jan 23; 4(6). PMID: 26798578    Free PMC article.
Viro-immune therapy: A new strategy for treatment of pancreatic cancer.
Andrea Marie Ibrahim, Yao-He Wang.
World J Gastroenterol, 2016 Jan 27; 22(2). PMID: 26811622    Free PMC article.
Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma.
Hae Yong Yoo, Pora Kim, +9 authors, Sanghyuk Lee.
Haematologica, 2016 Jan 29; 101(6). PMID: 26819049    Free PMC article.
Predicting analysis times in randomized clinical trials with cancer immunotherapy.
Tai-Tsang Chen.
BMC Med Res Methodol, 2016 Feb 03; 16. PMID: 26830911    Free PMC article.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too?
Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella.
Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028    Free PMC article.
Combination Therapies for Melanoma: A New Standard of Care?
Keiran S M Smalley, Zeynep Eroglu, Vernon K Sondak.
Am J Clin Dermatol, 2016 Feb 11; 17(2). PMID: 26860106    Free PMC article.
The Lymphatic System in Disease Processes and Cancer Progression.
Timothy P Padera, Eelco F J Meijer, Lance L Munn.
Annu Rev Biomed Eng, 2016 Feb 13; 18. PMID: 26863922    Free PMC article.
Basics of PD-1 in self-tolerance, infection, and cancer immunity.
Shunsuke Chikuma.
Int J Clin Oncol, 2016 Feb 13; 21(3). PMID: 26864303
Predictive and Prognostic Role of Tumor-Infiltrating Lymphocytes for Early Breast Cancer According to Disease Subtypes: Sensitivity Analysis of Randomized Trials in Adjuvant and Neoadjuvant Setting.
Luisa Carbognin, Sara Pilotto, +6 authors, Giampaolo Tortora.
Oncologist, 2016 Feb 13; 21(3). PMID: 26865589    Free PMC article.
Immune-based Therapy Clinical Trials in Hepatocellular Carcinoma.
Dai Liu, Kevin F Staveley-O'Carroll, Guangfu Li.
J Clin Cell Immunol, 2016 Feb 16; 6(6). PMID: 26877890    Free PMC article.
Immunotherapy for Gastric Cancer: A Focus on Immune Checkpoints.
Maria Alsina, Markus Moehler, +2 authors, Josep Tabernero.
Target Oncol, 2016 Feb 18; 11(4). PMID: 26880697
Ipilimumab (Anti-Ctla-4 Mab) in the treatment of metastatic melanoma: Effectiveness and toxicity management.
Paola Savoia, Chiara Astrua, Paolo Fava.
Hum Vaccin Immunother, 2016 Feb 19; 12(5). PMID: 26889818    Free PMC article.
Evaluation of Costimulatory Molecules in Peripheral Blood Lymphocytes of Canine Patients with Histiocytic Sarcoma.
Michihito Tagawa, Naoya Maekawa, Satoru Konnai, Satoshi Takagi.
PLoS One, 2016 Feb 24; 11(2). PMID: 26901565    Free PMC article.
Cutting Edge: Engineering Active IKKβ in T Cells Drives Tumor Rejection.
César Evaristo, Stefani Spranger, +5 authors, Maria-Luisa Alegre.
J Immunol, 2016 Feb 24; 196(7). PMID: 26903482    Free PMC article.
The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer.
Jeffrey P Ward, Matthew M Gubin, Robert D Schreiber.
Adv Immunol, 2016 Mar 01; 130. PMID: 26922999    Free PMC article.
Highly Cited. Review.
Blocking immune checkpoints in prostate, kidney, and urothelial cancer: An overview.
Angela K B Alme, Beerinder S Karir, Bishoy M Faltas, Charles G Drake.
Urol Oncol, 2016 Mar 01; 34(4). PMID: 26923782    Free PMC article.
Development of immuno-oncology drugs - from CTLA4 to PD1 to the next generations.
Axel Hoos.
Nat Rev Drug Discov, 2016 Mar 12; 15(4). PMID: 26965203
Highly Cited.
Combining Epigenetic and Immunotherapy to Combat Cancer.
Katherine B Chiappinelli, Cynthia A Zahnow, Nita Ahuja, Stephen B Baylin.
Cancer Res, 2016 Mar 19; 76(7). PMID: 26988985    Free PMC article.
Highly Cited. Review.
Tremelimumab: research and clinical development.
Begoña Comin-Anduix, Helena Escuin-Ordinas, Francisco Javier Ibarrondo.
Onco Targets Ther, 2016 Apr 05; 9. PMID: 27042127    Free PMC article.
The role of neoantigens in response to immune checkpoint blockade.
Nadeem Riaz, Luc Morris, +3 authors, Timothy A Chan.
Int Immunol, 2016 Apr 07; 28(8). PMID: 27048318    Free PMC article.
Manipulating TLR Signaling Increases the Anti-tumor T Cell Response Induced by Viral Cancer Therapies.
Juan J Rojas, Padma Sampath, +4 authors, Steve H Thorne.
Cell Rep, 2016 Apr 07; 15(2). PMID: 27050526    Free PMC article.
Immunotherapy for cancer in the central nervous system: Current and future directions.
David C Binder, Andrew A Davis, Derek A Wainwright.
Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057463    Free PMC article.
Highly Cited. Review.
Cocktails for cancer with a measure of immunotherapy.
Heidi Ledford.
Nature, 2016 Apr 15; 532(7598). PMID: 27075078
Emerging Opportunities and Challenges in Cancer Immunotherapy.
Theresa L Whiteside, Sandra Demaria, +2 authors, Ignacio Melero.
Clin Cancer Res, 2016 Apr 17; 22(8). PMID: 27084738    Free PMC article.
Highly Cited. Review.
Immune Checkpoint Therapy and the Search for Predictive Biomarkers.
Padmanee Sharma.
Cancer J, 2016 Apr 26; 22(2). PMID: 27111900    Free PMC article.
Immune Checkpoint Therapies in Prostate Cancer.
Sangeeta Goswami, Ana Aparicio, Sumit K Subudhi.
Cancer J, 2016 Apr 26; 22(2). PMID: 27111907    Free PMC article.
Potentiation of immunomodulatory antibody therapy with oncolytic viruses for treatment of cancer.
Dmitriy Zamarin, Jedd D Wolchok.
Mol Ther Oncolytics, 2014 Jan 01; 1. PMID: 27119094    Free PMC article.
Radiation therapy and the abscopal effect: a concept comes of age.
John Ng, Tong Dai.
Ann Transl Med, 2016 Apr 30; 4(6). PMID: 27127771    Free PMC article.
Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination.
Celine Boutros, Ahmad Tarhini, +14 authors, Caroline Robert.
Nat Rev Clin Oncol, 2016 May 05; 13(8). PMID: 27141885
Highly Cited. Review.
Cancer immunotherapy: the beginning of the end of cancer?
Sofia Farkona, Eleftherios P Diamandis, Ivan M Blasutig.
BMC Med, 2016 May 07; 14. PMID: 27151159    Free PMC article.
Highly Cited. Review.
Bilateral neuroretinitis and anterior uveitis following ipilimumab treatment for metastatic melanoma.
Laura Hahn, Kathryn L Pepple.
J Ophthalmic Inflamm Infect, 2016 May 12; 6(1). PMID: 27165193    Free PMC article.
Targeting immune checkpoints in unresectable metastatic cutaneous melanoma: a systematic review and meta-analysis of anti-CTLA-4 and anti-PD-1 agents trials.
Seongseok Yun, Nicole D Vincelette, +2 authors, Ivo Abraham.
Cancer Med, 2016 May 12; 5(7). PMID: 27167347    Free PMC article.
Systematic Review.
PD-1 marks dysfunctional regulatory T cells in malignant gliomas.
Daniel E Lowther, Brittany A Goods, +10 authors, David A Hafler.
JCI Insight, 2016 May 18; 1(5). PMID: 27182555    Free PMC article.
Highly Cited.
Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity.
Luke S Manlove, Jason M Schenkel, +4 authors, Michael A Farrar.
J Immunol, 2016 May 18; 196(11). PMID: 27183622    Free PMC article.
Checkpoint Inhibitors and Other Immune Therapies for Hodgkin and Non-Hodgkin Lymphoma.
Eri Matsuki, Anas Younes.
Curr Treat Options Oncol, 2016 May 20; 17(6). PMID: 27193488    Free PMC article.
Burden of Nonsynonymous Mutations among TCGA Cancers and Candidate Immune Checkpoint Inhibitor Responses.
Leandro M Colli, Mitchell J Machiela, +3 authors, Stephen J Chanock.
Cancer Res, 2016 May 20; 76(13). PMID: 27197178    Free PMC article.
Highly Cited.
The oncolytic virus ΔPK has multimodal anti-tumor activity.
Laure Aurelian, Dominique Bollino, Aric Colunga.
Pathog Dis, 2016 Jun 01; 74(5). PMID: 27242376    Free PMC article.
Revisiting of cancer vaccine?-Specific immunotherapy comes to field with the biomarker.
Yuki Owada, Satoshi Muto, +2 authors, Hiroyuki Suzuki.
Ann Transl Med, 2016 Jun 09; 4(9). PMID: 27275492    Free PMC article.
Checkpoint inhibitors and other novel immunotherapies for advanced renal cell carcinoma.
Maria I Carlo, Martin H Voss, Robert J Motzer.
Nat Rev Urol, 2016 Jun 22; 13(7). PMID: 27324121    Free PMC article.
Immune checkpoint blockade therapy for bladder cancer treatment.
Jayoung Kim.
Investig Clin Urol, 2016 Jun 22; 57 Suppl 1. PMID: 27326412    Free PMC article.
Association between the cytotoxic T-lymphocyte antigen 4-318C/T polymorphism and malignant tumor risk.
Taiming Li, Chengdi Wang, +4 authors, Min Liu.
Biomed Rep, 2016 Jun 28; 5(1). PMID: 27347411    Free PMC article.
Immune checkpoint inhibitor combinations in solid tumors: opportunities and challenges.
Chrisann Kyi, Michael A Postow.
Immunotherapy, 2016 Jun 29; 8(7). PMID: 27349981    Free PMC article.
Highly Cited. Review.
Molecular Profile of Tumor-Specific CD8+ T Cell Hypofunction in a Transplantable Murine Cancer Model.
Katherine A Waugh, Sonia M Leach, +3 authors, Jill E Slansky.
J Immunol, 2016 Jul 03; 197(4). PMID: 27371726    Free PMC article.
Oncolytic Virus-Mediated Targeting of PGE2 in the Tumor Alters the Immune Status and Sensitizes Established and Resistant Tumors to Immunotherapy.
Weizhou Hou, Padma Sampath, Juan J Rojas, Steve H Thorne.
Cancer Cell, 2016 Jul 05; 30(1). PMID: 27374223    Free PMC article.
A phase I study of intratumoral ipilimumab and interleukin-2 in patients with advanced melanoma.
Abhijit Ray, Matthew A Williams, +12 authors, Hung T Khong.
Oncotarget, 2016 Jul 09; 7(39). PMID: 27391442    Free PMC article.
A Perspective of Immunotherapy for Prostate Cancer.
Ida Silvestri, Susanna Cattarino, +3 authors, Alessandro Sciarra.
Cancers (Basel), 2016 Jul 12; 8(7). PMID: 27399780    Free PMC article.
Metastatic melanoma and immunotherapy.
Benjamin Herzberg, David E Fisher.
Clin Immunol, 2016 Jul 20; 172. PMID: 27430520    Free PMC article.
A Mini-Review for Cancer Immunotherapy: Molecular Understanding of PD-1/PD-L1 Pathway & Translational Blockade of Immune Checkpoints.
Yongshu Li, Fangfei Li, +4 authors, Ge Zhang.
Int J Mol Sci, 2016 Jul 22; 17(7). PMID: 27438833    Free PMC article.
Highly Cited. Review.
Stereotactic Ablative Radiation Therapy Combined With Immunotherapy for Solid Tumors.
Eric D Brooks, Jonathan E Schoenhals, +4 authors, James W Welsh.
Cancer J, 2016 Jul 22; 22(4). PMID: 27441745    Free PMC article.
Magneto-nanosensor platform for probing low-affinity protein-protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction.
Jung-Rok Lee, Daniel J B Bechstein, +5 authors, Shan X Wang.
Nat Commun, 2016 Jul 23; 7. PMID: 27447090    Free PMC article.
Releasing the brakes to fight cancer: The recent discovery of checkpoints has boosted the field of cancer immunotherapy.
Katrin Weigmann.
EMBO Rep, 2016 Jul 28; 17(9). PMID: 27458238    Free PMC article.
CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma.
Guang-Tao Yu, Lin-Lin Bu, +5 authors, Zhi-Jun Sun.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471622    Free PMC article.
Role of IL-2 in cancer immunotherapy.
Tao Jiang, Caicun Zhou, Shengxiang Ren.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471638    Free PMC article.
Highly Cited. Review.
CD28 co-stimulation in T-cell homeostasis: a recent perspective.
Niklas Beyersdorf, Thomas Kerkau, Thomas Hünig.
Immunotargets Ther, 2015 Jan 01; 4. PMID: 27471717    Free PMC article.
Oncogenes: The Passport for Viral Oncolysis Through PKR Inhibition.
Janaina Fernandes.
Biomark Cancer, 2016 Aug 04; 8. PMID: 27486347    Free PMC article.
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.
Lewis Zhichang Shi, Tihui Fu, +7 authors, Padmanee Sharma.
Nat Commun, 2016 Aug 09; 7. PMID: 27498556    Free PMC article.
Novel therapeutic strategies in human malignancy: combining immunotherapy and oncolytic virotherapy.
Padma Sampath, Steve H Thorne.
Oncolytic Virother, 2015 Jan 01; 4. PMID: 27512672    Free PMC article.
Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer.
Benjamin Herzberg, Meghan J Campo, Justin F Gainor.
Oncologist, 2016 Aug 19; 22(1). PMID: 27534574    Free PMC article.
Harnessing the immune system to improve cancer therapy.
Nikos E Papaioannou, Ourania V Beniata, +2 authors, Pinelopi Samara.
Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563648    Free PMC article.
Highly Cited. Review.
Immune checkpoint inhibitors: the new frontier in non-small-cell lung cancer treatment.
Hazem El-Osta, Kamran Shahid, Glenn M Mills, Prakash Peddi.
Onco Targets Ther, 2016 Aug 31; 9. PMID: 27574451    Free PMC article.
Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy.
David B Page, Jianda Yuan, +22 authors, Heather L McArthur.
Cancer Immunol Res, 2016 Sep 03; 4(10). PMID: 27587469    Free PMC article.
Specific CD8(+) T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis.
Elia Moreno-Cubero, Juan-Ramón Larrubia.
World J Gastroenterol, 2016 Sep 09; 22(28). PMID: 27605882    Free PMC article.
NLRC4 suppresses melanoma tumor progression independently of inflammasome activation.
Ann M Janowski, Oscar R Colegio, +7 authors, Fayyaz S Sutterwala.
J Clin Invest, 2016 Sep 13; 126(10). PMID: 27617861    Free PMC article.
Ipilimumab reshapes T cell memory subsets in melanoma patients with clinical response.
Joana Felix, Jérome Lambert, +13 authors, Hélène Moins-Teisserenc.
Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622012    Free PMC article.
Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy.
Geoffrey S Williams, Bina Mistry, +20 authors, Robert W Wilkinson.
Oncotarget, 2016 Sep 15; 7(42). PMID: 27626702    Free PMC article.
T-Cell-Based Immunotherapy for Osteosarcoma: Challenges and Opportunities.
Zhan Wang, Binghao Li, Yingqing Ren, Zhaoming Ye.
Front Immunol, 2016 Sep 30; 7. PMID: 27683579    Free PMC article.
Trends and advances in tumor immunology and lung cancer immunotherapy.
Mohanad Aldarouish, Cailian Wang.
J Exp Clin Cancer Res, 2016 Oct 01; 35(1). PMID: 27686848    Free PMC article.
Mouse models in oncoimmunology.
Laurence Zitvogel, Jonathan M Pitt, +2 authors, Guido Kroemer.
Nat Rev Cancer, 2016 Nov 04; 16(12). PMID: 27687979
Highly Cited. Review.
Genomic Approaches to Understanding Response and Resistance to Immunotherapy.
David A Braun, Kelly P Burke, Eliezer M Van Allen.
Clin Cancer Res, 2016 Oct 05; 22(23). PMID: 27698000    Free PMC article.
Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment.
Yang Liu, Srilakshmi Pandeswara, +6 authors, Tyler J Curiel.
Cancer Res, 2016 Oct 16; 77(2). PMID: 27737881    Free PMC article.
Combining Radiation Therapy with Immune Checkpoint Blockade for Central Nervous System Malignancies.
Neil M D'Souza, Penny Fang, +3 authors, Jing Li.
Front Oncol, 2016 Oct 25; 6. PMID: 27774435    Free PMC article.
Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.
Hanna Starobinets, Jordan Ye, +6 authors, Jayanta Debnath.
J Clin Invest, 2016 Oct 25; 126(12). PMID: 27775547    Free PMC article.
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway.
Vassiliki A Boussiotis.
N Engl J Med, 2016 Nov 03; 375(18). PMID: 27806234    Free PMC article.
Highly Cited. Review.
A Journey in Science: "Not Lost in Translation".
Tak Mak.
Mol Med, 2016 Nov 08; 22. PMID: 27819109    Free PMC article.
Cell-Intrinsic Barriers of T Cell-Based Immunotherapy.
Hazem E Ghoneim, Anthony E Zamora, Paul G Thomas, Ben A Youngblood.
Trends Mol Med, 2016 Nov 09; 22(12). PMID: 27825667    Free PMC article.
Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeting nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme.
Szu-Ting Chou, Rameshwar Patil, +14 authors, Julia Y Ljubimova.
J Control Release, 2016 Nov 09; 244(Pt A). PMID: 27825958    Free PMC article.
Combinatorial immunotherapy for melanoma.
D D George, V A Armenio, S C Katz.
Cancer Gene Ther, 2016 Nov 12; 24(3). PMID: 27834353
Emerging role of immunotherapy in urothelial carcinoma-Immunobiology/biomarkers.
Randy F Sweis, Matthew D Galsky.
Urol Oncol, 2016 Nov 12; 34(12). PMID: 27836246    Free PMC article.
Checkpoint Proteins in Pediatric Brain and Extracranial Solid Tumors: Opportunities for Immunotherapy.
Eric K Ring, James M Markert, G Yancey Gillespie, Gregory K Friedman.
Clin Cancer Res, 2016 Nov 12; 23(2). PMID: 27836863    Free PMC article.
Ipilimumab: from preclinical development to future clinical perspectives in melanoma.
Paul Letendre, Varun Monga, Mohammed Milhem, Yousef Zakharia.
Future Oncol, 2016 Nov 25; 13(7). PMID: 27882779    Free PMC article.
Combined VEGFR and CTLA-4 blockade increases the antigen-presenting function of intratumoral DCs and reduces the suppressive capacity of intratumoral MDSCs.
Stephanie Du Four, Sarah K Maenhout, +3 authors, Joeri L Aerts.
Am J Cancer Res, 2016 Dec 03; 6(11). PMID: 27904768    Free PMC article.
Immunotherapy of head and neck cancer: Emerging clinical trials from a National Cancer Institute Head and Neck Cancer Steering Committee Planning Meeting.
Julie E Bauman, Ezra Cohen, +17 authors, Shakun Malik.
Cancer, 2016 Dec 03; 123(7). PMID: 27906454    Free PMC article.
Gene expression profiling of anti-CTLA4-treated metastatic melanoma in patients with treatment-induced autoimmunity.
Scott C Bresler, Le Min, +6 authors, Christine G Lian.
Lab Invest, 2016 Dec 06; 97(2). PMID: 27918555
Immune checkpoint therapy for pancreatic cancer.
Henrik Johansson, Roland Andersson, +3 authors, Daniel Ansari.
World J Gastroenterol, 2016 Dec 07; 22(43). PMID: 27920468    Free PMC article.
Phase I study of Nivolumab, an anti-PD-1 antibody, in patients with malignant solid tumors.
Noboru Yamamoto, Hiroshi Nokihara, +7 authors, Tomohide Tamura.
Invest New Drugs, 2016 Dec 09; 35(2). PMID: 27928714    Free PMC article.
Molecular Pathways: The Necrosome-A Target for Cancer Therapy.
Lena Seifert, George Miller.
Clin Cancer Res, 2016 Dec 10; 23(5). PMID: 27932417    Free PMC article.
Potent CD4+ T cell-associated antitumor memory responses induced by trifunctional bispecific antibodies in combination with immune checkpoint inhibition.
Nina Deppisch, Peter Ruf, +2 authors, Ralph Mocikat.
Oncotarget, 2016 Dec 15; 8(3). PMID: 27966460    Free PMC article.
Immune Checkpoint Blockade in Hepatocellular Carcinoma: 2017 Update.
M Kudo.
Liver Cancer, 2016 Dec 21; 6(1). PMID: 27995082    Free PMC article.
Cytokines and metabolic factors regulate tumoricidal T-cell function during cancer immunotherapy.
Adam J Adler, Payal Mittal, +3 authors, Anthony T Vella.
Immunotherapy, 2016 Dec 22; 9(1). PMID: 28000531    Free PMC article.
Genetically engineered mouse models in oncology research and cancer medicine.
Kelly Kersten, Karin E de Visser, Martine H van Miltenburg, Jos Jonkers.
EMBO Mol Med, 2016 Dec 29; 9(2). PMID: 28028012    Free PMC article.
Highly Cited. Review.
A New VISTA on combination therapy for negative checkpoint regulator blockade.
Jie Deng, Isabelle Le Mercier, Anna Kuta, Randolph J Noelle.
J Immunother Cancer, 2016 Dec 30; 4. PMID: 28031817    Free PMC article.
A current perspective on cancer immune therapy: step-by-step approach to constructing the magic bullet.
Gabriele D'Errico, Heather L Machado, Bruno Sainz.
Clin Transl Med, 2017 Jan 05; 6(1). PMID: 28050779    Free PMC article.
A special issue on cancer immunotherapy.
Rong-Fu Wang.
Cell Res, 2017 Jan 07; 27(1). PMID: 28057935    Free PMC article.
Immunotherapy: incorporation in the evolving paradigm of renal cancer management and future prospects.
Kenneth G Liu, Sorab Gupta, Sanjay Goel.
Oncotarget, 2017 Jan 07; 8(10). PMID: 28061473    Free PMC article.
New Immunotherapy Strategies in Breast Cancer.
Lin-Yu Yu, Jie Tang, +4 authors, Xiao-Ping Chen.
Int J Environ Res Public Health, 2017 Jan 14; 14(1). PMID: 28085094    Free PMC article.
Immune-Checkpoint Inhibitors in the Era of Precision Medicine: What Radiologists Should Know.
Marta Braschi-Amirfarzan, Sree Harsha Tirumani, Frank Stephen Hodi, Mizuki Nishino.
Korean J Radiol, 2017 Jan 18; 18(1). PMID: 28096717    Free PMC article.
CTLA-4 polymorphisms associate with breast cancer susceptibility in Asians: a meta-analysis.
Zhiming Dai, Tian Tian, +9 authors, Zhijun Dai.
PeerJ, 2017 Jan 18; 5. PMID: 28097051    Free PMC article.
Is the Genetic Background of Co-Stimulatory CD28/CTLA-4 Pathway the Risk Factor for Prostate Cancer?
Lidia Karabon, K Tupikowski, +7 authors, I Frydecka.
Pathol Oncol Res, 2017 Jan 20; 23(4). PMID: 28101800
Elements of cancer immunity and the cancer-immune set point.
Daniel S Chen, Ira Mellman.
Nature, 2017 Jan 20; 541(7637). PMID: 28102259
Highly Cited. Review.
New Combination Strategies Using Programmed Cell Death 1/Programmed Cell Death Ligand 1 Checkpoint Inhibitors as a Backbone.
Siwen Hu-Lieskovan, Antoni Ribas.
Cancer J, 2017 Jan 24; 23(1). PMID: 28114250    Free PMC article.
PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective.
Jun Wang, Ruirong Yuan, +3 authors, Zihai Li.
J Hematol Oncol, 2017 Jan 27; 10(1). PMID: 28122590    Free PMC article.
Highly Cited. Review.
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy.
Padmanee Sharma, Siwen Hu-Lieskovan, Jennifer A Wargo, Antoni Ribas.
Cell, 2017 Feb 12; 168(4). PMID: 28187290    Free PMC article.
Highly Cited. Review.
Emerging role of checkpoint blockade therapy in lymphoma.
Natalie Galanina, Justin Kline, Michael R Bishop.
Ther Adv Hematol, 2017 Feb 17; 8(2). PMID: 28203344    Free PMC article.
The prognostic value of cytotoxic T-lymphocyte antigen 4 in cancers: a systematic review and meta-analysis.
Pingping Hu, Qiqi Liu, +4 authors, Jiandong Zhang.
Sci Rep, 2017 Feb 18; 7. PMID: 28211499    Free PMC article.
Systematic Review.
Cardiovascular Toxicities Associated with Cancer Immunotherapies.
Daniel Y Wang, Gosife Donald Okoye, +2 authors, Javid J Moslehi.
Curr Cardiol Rep, 2017 Feb 22; 19(3). PMID: 28220466
Highly Cited. Review.
Immune Checkpoint Blockade Biology in Mouse Models of Glioblastoma.
Alan T Yeo, Alain Charest.
J Cell Biochem, 2017 Feb 24; 118(9). PMID: 28230277    Free PMC article.
[18F]Fluorodeoxyglucose Positron Emission Tomography Reveals a Complete Remission of Refractory Metastatic Melanoma after Therapy with Ipilimumab.
Anna Yordanova, Carl Schlenkhoff, +2 authors, Hojjat Ahmadzadehfar.
Indian J Nucl Med, 2017 Mar 01; 32(1). PMID: 28242993    Free PMC article.
The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors.
Andrew S Luksik, Russell Maxwell, Tomas Garzon-Muvdi, Michael Lim.
Neurotherapeutics, 2017 Mar 05; 14(4). PMID: 28258545    Free PMC article.
Introduction to checkpoint inhibitors and cancer immunotherapy.
Arlene H Sharpe.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258698    Free PMC article.
Immunotherapy in pancreatic cancer treatment: a new frontier.
Komal Thind, Leslie J Padrnos, Ramesh K Ramanathan, Mitesh J Borad.
Therap Adv Gastroenterol, 2017 Mar 14; 10(1). PMID: 28286568    Free PMC article.
Immune checkpoint inhibition and its relationship with hypermutation phenoytype as a potential treatment for Glioblastoma.
Manohan Sinnadurai, Kerrie L McDonald.
J Neurooncol, 2017 Mar 16; 132(3). PMID: 28293764
Current modalities in cancer immunotherapy: Immunomodulatory antibodies, CARs and vaccines.
Jason Lohmueller, Olivera J Finn.
Pharmacol Ther, 2017 Mar 23; 178. PMID: 28322974    Free PMC article.
Mechanistic and pharmacologic insights on immune checkpoint inhibitors.
Randy F Sweis, Jason J Luke.
Pharmacol Res, 2017 Mar 23; 120. PMID: 28323141    Free PMC article.
Biological mechanisms of immune escape and implications for immunotherapy in head and neck squamous cell carcinoma.
Jennifer D Moy, Jessica M Moskovitz, Robert L Ferris.
Eur J Cancer, 2017 Mar 23; 76. PMID: 28324750    Free PMC article.
Aptamers for CD Antigens: From Cell Profiling to Activity Modulation.
Amin Nozari, Maxim V Berezovski.
Mol Ther Nucleic Acids, 2017 Mar 23; 6. PMID: 28325295    Free PMC article.
Interleukin-2 in Renal Cell Carcinoma: A Has-Been or a Still-Viable Option?
Asim Amin, Richard L White.
J Kidney Cancer VHL, 2014 Jan 01; 1(7). PMID: 28326252    Free PMC article.
IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients.
Rossana Tallerico, Costanza M Cristiani, +21 authors, Ennio Carbone.
Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344869    Free PMC article.
Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure.
Wafa Khamri, Robin D Abeles, +17 authors, Charalambos G Antoniades.
Gastroenterology, 2017 Apr 02; 153(1). PMID: 28363639    Free PMC article.
Targeted agents and immunotherapies: optimizing outcomes in melanoma.
Jason J Luke, Keith T Flaherty, Antoni Ribas, Georgina V Long.
Nat Rev Clin Oncol, 2017 Apr 05; 14(8). PMID: 28374786
Highly Cited. Review.
CD8 T-cell regulation by T regulatory cells and the programmed cell death protein 1 pathway.
Pablo Penaloza-MacMaster.
Immunology, 2017 Apr 05; 151(2). PMID: 28375543    Free PMC article.
Cancer immunotherapies targeting the PD-1 signaling pathway.
Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto, Tasuku Honjo.
J Biomed Sci, 2017 Apr 06; 24(1). PMID: 28376884    Free PMC article.
Highly Cited. Review.
Antigen Discovery and Therapeutic Targeting in Hematologic Malignancies.
David A Braun, Catherine J Wu.
Cancer J, 2017 Apr 15; 23(2). PMID: 28410299    Free PMC article.
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden.
Zachary R Chalmers, Caitlin F Connelly, +21 authors, Garrett M Frampton.
Genome Med, 2017 Apr 20; 9(1). PMID: 28420421    Free PMC article.
Highly Cited.
Ipilimumab treatment decreases monocytic MDSCs and increases CD8 effector memory T cells in long-term survivors with advanced melanoma.
Yago Pico de Coaña, Maria Wolodarski, +9 authors, Rolf Kiessling.
Oncotarget, 2017 Apr 21; 8(13). PMID: 28423487    Free PMC article.
Influence of ipilimumab on expanded tumour derived T cells from patients with metastatic melanoma.
Jon Bjoern, Rikke Lyngaa, +4 authors, Inge Marie Svane.
Oncotarget, 2017 Apr 21; 8(16). PMID: 28423678    Free PMC article.
Checkpoint inhibitors in hematological malignancies.
Chi Young Ok, Ken H Young.
J Hematol Oncol, 2017 May 10; 10(1). PMID: 28482851    Free PMC article.
Highly Cited. Review.
In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy.
Sean P Arlauckas, Christopher S Garris, +9 authors, Mikael J Pittet.
Sci Transl Med, 2017 May 12; 9(389). PMID: 28490665    Free PMC article.
Highly Cited.
Current status of chimeric antigen receptor engineered T cell-based and immune checkpoint blockade-based cancer immunotherapies.
Upendra P Hegde, Bijay Mukherji.
Cancer Immunol Immunother, 2017 May 13; 66(9). PMID: 28497159    Free PMC article.
Mechanisms of Immune Tolerance in Leukemia and Lymphoma.
Emily K Curran, James Godfrey, Justin Kline.
Trends Immunol, 2017 May 18; 38(7). PMID: 28511816    Free PMC article.
PD-1 targeted Immunotherapy as first-line therapy for advanced non-small-cell lung cancer patients.
Arik Bernard Schulze, Lars Henning Schmidt.
J Thorac Dis, 2017 May 20; 9(4). PMID: 28523184    Free PMC article.
Mini-review of conventional and hypofractionated radiation therapy combined with immunotherapy for non-small cell lung cancer.
Allison M Campbell, Roy H Decker.
Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529904    Free PMC article.
Immune Checkpoint Inhibitor Therapy: What Line of Therapy and How to Choose?
Chethan Ramamurthy, James L Godwin, Hossein Borghaei.
Curr Treat Options Oncol, 2017 May 24; 18(6). PMID: 28534248
Cancer Vaccines in Ovarian Cancer: How Can We Improve?
Silvia Martin Lluesma, Anita Wolfer, Alexandre Harari, Lana E Kandalaft.
Biomedicines, 2017 May 26; 4(2). PMID: 28536377    Free PMC article.
Interaction of molecular alterations with immune response in melanoma.
Robert A Szczepaniak Sloane, Vancheswaran Gopalakrishnan, +3 authors, Jennifer A Wargo.
Cancer, 2017 May 26; 123(S11). PMID: 28543700    Free PMC article.
Delivering safer immunotherapies for cancer.
Lauren Milling, Yuan Zhang, Darrell J Irvine.
Adv Drug Deliv Rev, 2017 May 27; 114. PMID: 28545888    Free PMC article.
Highly Cited. Review.
Antibody-mediated neutralization of soluble MIC significantly enhances CTLA4 blockade therapy.
Jingyu Zhang, Dai Liu, +4 authors, Jennifer D Wu.
Sci Adv, 2017 Jun 01; 3(5). PMID: 28560327    Free PMC article.
Genetically Engineered Vaccinia Viruses As Agents for Cancer Treatment, Imaging, and Transgene Delivery.
Dana Haddad.
Front Oncol, 2017 Jun 08; 7. PMID: 28589082    Free PMC article.
QnAs with Tony Hunter and James Allison.
Prashant Nair.
Proc Natl Acad Sci U S A, 2017 Jun 21; 114(26). PMID: 28630309    Free PMC article.
CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation.
Holger Lingel, Josef Wissing, +7 authors, Monika C Brunner-Weinzierl.
Cell Death Differ, 2017 Jun 24; 24(10). PMID: 28644433    Free PMC article.
Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity.
Andrés Alloatti, Derek C Rookhuizen, +8 authors, Sebastian Amigorena.
J Exp Med, 2017 Jul 01; 214(8). PMID: 28663435    Free PMC article.
The emerging role of immune checkpoint based approaches in AML and MDS.
Prajwal Boddu, Hagop Kantarjian, +3 authors, Naval Daver.
Leuk Lymphoma, 2017 Jul 07; 59(4). PMID: 28679300    Free PMC article.
Genetic Mutations and Epigenetic Modifications: Driving Cancer and Informing Precision Medicine.
Krysta Mila Coyle, Jeanette E Boudreau, Paola Marcato.
Biomed Res Int, 2017 Jul 08; 2017. PMID: 28685150    Free PMC article.
Targeted therapies for renal cell carcinoma.
Edwin M Posadas, Suwicha Limvorasak, Robert A Figlin.
Nat Rev Nephrol, 2017 Jul 12; 13(8). PMID: 28691713
Highly Cited. Review.
Developing Cures: Targeting Ontogenesis in Cancer.
Victor T G Lin, Hawley C Pruitt, Rajeev S Samant, Lalita A Shevde.
Trends Cancer, 2017 Jul 19; 3(2). PMID: 28718443    Free PMC article.
Immunological tolerance as a barrier to protective HIV humoral immunity.
Kristin Ms Schroeder, Amanda Agazio, Raul M Torres.
Curr Opin Immunol, 2017 Jul 21; 47. PMID: 28728075    Free PMC article.
CTLA4-CD28 chimera gene modification of T cells enhances the therapeutic efficacy of donor lymphocyte infusion for hematological malignancy.
Hyung Bae Park, Ji Eun Lee, +3 authors, Kyungho Choi.
Exp Mol Med, 2017 Jul 29; 49(7). PMID: 28751785    Free PMC article.
Tools to define the melanoma-associated immunopeptidome.
Eva Bräunlein, Angela M Krackhardt.
Immunology, 2017 Jul 30; 152(4). PMID: 28755382    Free PMC article.
Immunotherapy: Who Is Eligible?
Daniel Wang, Jill Gilbert, Young J Kim.
Otolaryngol Clin North Am, 2017 Aug 02; 50(4). PMID: 28755708    Free PMC article.
Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer.
Clemence Granier, Eleonore De Guillebon, +7 authors, Eric Tartour.
ESMO Open, 2017 Aug 02; 2(2). PMID: 28761757    Free PMC article.
Highly Cited. Review.
Listening to each other: Infectious disease and cancer immunology.
Russell E Vance, Michael J Eichberg, Daniel A Portnoy, David H Raulet.
Sci Immunol, 2017 Aug 08; 2(7). PMID: 28783669    Free PMC article.
Awakening immunity against cancer: a 2017 primer for clinicians.
Amit Jain, Qing Zhang, Han-Chong Toh.
Chin J Cancer, 2017 Aug 22; 36(1). PMID: 28823251    Free PMC article.
Cancer Immunotherapy: Historical Perspective of a Clinical Revolution and Emerging Preclinical Animal Models.
William K Decker, Rodrigo F da Silva, +5 authors, Silke Paust.
Front Immunol, 2017 Aug 22; 8. PMID: 28824608    Free PMC article.
Highly Cited. Review.
The 150 most important questions in cancer research and clinical oncology series: questions 50-56.
Chinese Journal of Cancer.
Chin J Cancer, 2017 Aug 30; 36(1). PMID: 28847311    Free PMC article.
Immune checkpoint inhibitors in cancer therapy.
Eika S Webb, Peng Liu, +3 authors, Yao-He Wang.
J Biomed Res, 2017 Sep 04; 32(5). PMID: 28866656    Free PMC article.
PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome.
Hashem O Alsaab, Samaresh Sau, +4 authors, Arun K Iyer.
Front Pharmacol, 2017 Sep 08; 8. PMID: 28878676    Free PMC article.
Highly Cited. Review.
Immunotherapy of Lymphoma and Myeloma: Facts and Hopes.
Matthew J Pianko, Alison J Moskowitz, Alexander M Lesokhin.
Clin Cancer Res, 2017 Sep 14; 24(5). PMID: 28899972    Free PMC article.
A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect.
Bo-Tsang Huang, Wei-Yun Lai, +4 authors, Pan-Chyr Yang.
Mol Ther Nucleic Acids, 2017 Sep 18; 8. PMID: 28918052    Free PMC article.
Profile of pembrolizumab in the treatment of head and neck squamous cell carcinoma: design development and place in therapy.
Sulsal Haque, Mahender Yellu, Jaskirat Randhawa, Nooshin Hashemi-Sadraei.
Drug Des Devel Ther, 2017 Sep 19; 11. PMID: 28919706    Free PMC article.
PD-L1 expression as poor prognostic factor in patients with non-squamous non-small cell lung cancer.
Cuiling Zhou, Jianjun Tang, +10 authors, Haiqing Ma.
Oncotarget, 2017 Sep 25; 8(35). PMID: 28938570    Free PMC article.
Immunomodulatory Monoclonal Antibodies in Combined Immunotherapy Trials for Cutaneous Melanoma.
Mariana Aris, José Mordoh, María Marcela Barrio.
Front Immunol, 2017 Oct 04; 8. PMID: 28970830    Free PMC article.
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Romualdo Barroso-Sousa, William T Barry, +4 authors, Sara M Tolaney.
JAMA Oncol, 2017 Oct 04; 4(2). PMID: 28973656    Free PMC article.
Highly Cited. Systematic Review.
Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies.
Mengnan He, Yan Chai, +6 authors, George F Gao.
Oncotarget, 2017 Oct 06; 8(40). PMID: 28978021    Free PMC article.
Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma.
Maria-Carmela Speranza, Carmela Passaro, +18 authors, Sean E Lawler.
Neuro Oncol, 2017 Oct 11; 20(2). PMID: 29016938    Free PMC article.
Efficacy and Safety of Pembrolizumab in Patients Enrolled in KEYNOTE-030 in the United States: An Expanded Access Program.
Tara C Gangadhar, Wen-Jen Hwu, +14 authors, April K S Salama.
J Immunother, 2017 Oct 14; 40(9). PMID: 29028788    Free PMC article.
CD4 and CD8 T lymphocyte interplay in controlling tumor growth.
Dmitrij Ostroumov, Nora Fekete-Drimusz, +2 authors, Norman Woller.
Cell Mol Life Sci, 2017 Oct 17; 75(4). PMID: 29032503    Free PMC article.
Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers.
Chan-Young Ock, Jun-Eul Hwang, +12 authors, Ju-Seog Lee.
Nat Commun, 2017 Oct 21; 8(1). PMID: 29051489    Free PMC article.
Immune checkpoint inhibitors in renal cell carcinoma.
Kirsty Ross, Rob J Jones.
Clin Sci (Lond), 2017 Oct 29; 131(21). PMID: 29079639    Free PMC article.
The association between CD28 gene rs3116496 polymorphism and breast cancer risk in Chinese women.
Yuxiang Yan, Xianbo Zhang.
Biosci Rep, 2017 Nov 02; 37(6). PMID: 29089469    Free PMC article.
Immune-Related Adverse Events Associated with Anti-PD-1/PD-L1 Treatment for Malignancies: A Meta-Analysis.
Peng-Fei Wang, Yang Chen, +5 authors, Chang-Xiang Yan.
Front Pharmacol, 2017 Nov 03; 8. PMID: 29093678    Free PMC article.
Highly Cited.
CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation.
Jiehui Deng, Eric S Wang, +44 authors, Kwok-Kin Wong.
Cancer Discov, 2017 Nov 05; 8(2). PMID: 29101163    Free PMC article.
Highly Cited.
Cardiotoxicity of immune checkpoint inhibitors.
Gilda Varricchi, Maria Rosaria Galdiero, +5 authors, Carlo Gabriele Tocchetti.
ESMO Open, 2017 Nov 07; 2(4). PMID: 29104763    Free PMC article.
Highly Cited. Review.
Imaging PD-L1 Expression with ImmunoPET.
Charles Truillet, Hsueh Ling J Oh, +19 authors, Michael J Evans.
Bioconjug Chem, 2017 Nov 11; 29(1). PMID: 29125731    Free PMC article.
CD4+ T Cell Differentiation in Chronic Viral Infections: The Tfh Perspective.
Laura A Vella, Ramin S Herati, E John Wherry.
Trends Mol Med, 2017 Nov 16; 23(12). PMID: 29137933    Free PMC article.
Immune checkpoint inhibitors: new strategies to checkmate cancer.
R A M Wilson, T R J Evans, A R Fraser, R J B Nibbs.
Clin Exp Immunol, 2017 Nov 16; 191(2). PMID: 29139554    Free PMC article.
Mixed Signals: Co-Stimulation in Invariant Natural Killer T Cell-Mediated Cancer Immunotherapy.
Susannah C Shissler, Michael S Lee, Tonya J Webb.
Front Immunol, 2017 Nov 23; 8. PMID: 29163518    Free PMC article.
Management of intracranial melanomas in the era of precision medicine.
Grace J Young, Wenya Linda Bi, +3 authors, Ian F Dunn.
Oncotarget, 2017 Nov 29; 8(51). PMID: 29179523    Free PMC article.
Development of a Diagnostic Programmed Cell Death 1-Ligand 1 Immunohistochemistry Assay for Nivolumab Therapy in Melanoma.
Therese Phillips, Molly M Millett, +14 authors, Henrik Winther.
Appl Immunohistochem Mol Morphol, 2017 Dec 01; 26(1). PMID: 29189265    Free PMC article.
Next generation antibody drugs: pursuit of the 'high-hanging fruit'.
Paul J Carter, Greg A Lazar.
Nat Rev Drug Discov, 2017 Dec 02; 17(3). PMID: 29192287
Highly Cited. Review.
Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma.
Arvind M Venkatesan, Rajesh Vyas, +12 authors, Craig J Ceol.
J Clin Invest, 2017 Dec 05; 128(1). PMID: 29202482    Free PMC article.
Soluble CD73 as biomarker in patients with metastatic melanoma patients treated with nivolumab.
Silvana Morello, Mariaelena Capone, +6 authors, Paolo Antonio Ascierto.
J Transl Med, 2017 Dec 06; 15(1). PMID: 29202855    Free PMC article.
Antigen-specific oncolytic MV-based tumor vaccines through presentation of selected tumor-associated antigens on infected cells or virus-like particles.
Stefan Hutzler, Stephanie Erbar, +9 authors, Michael D Mühlebach.
Sci Rep, 2017 Dec 06; 7(1). PMID: 29203786    Free PMC article.
Screening and antitumor effect of an anti‑CTLA‑4 nanobody.
Ruirong Wan, Aiqun Liu, +9 authors, Xiaoling Lu.
Oncol Rep, 2017 Dec 06; 39(2). PMID: 29207143    Free PMC article.
Newly Emerging Immune Checkpoints: Promises for Future Cancer Therapy.
Robert J Torphy, Richard D Schulick, Yuwen Zhu.
Int J Mol Sci, 2017 Dec 07; 18(12). PMID: 29211042    Free PMC article.
Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4.
Bi Shi, Jianlin Geng, +9 authors, Hui Hu.
J Immunol, 2017 Dec 08; 200(2). PMID: 29212910    Free PMC article.
Immunotherapies for malignant glioma.
Vassiliki A Boussiotis, Alain Charest.
Oncogene, 2017 Dec 16; 37(9). PMID: 29242608    Free PMC article.
Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy.
Anne-Sophie Gautron, Alexandre Juillerat, +5 authors, Laurent Poirot.
Mol Ther Nucleic Acids, 2017 Dec 17; 9. PMID: 29246309    Free PMC article.
Ipilimumab plus Lenalidomide after Allogeneic and Autologous Stem Cell Transplantation for Patients with Lymphoid Malignancies.
Issa F Khouri, Irina Fernandez Curbelo, +7 authors, Padmanee Sharma.
Clin Cancer Res, 2017 Dec 17; 24(5). PMID: 29246938    Free PMC article.
Novel immunotherapy approaches for metastatic urothelial and renal cell carcinoma.
Zhiying Shao, Andrew Z Wang, Daniel J George, Tian Zhang.
Asian J Urol, 2016 Oct 01; 3(4). PMID: 29264195    Free PMC article.
How Checkpoint Inhibitors Are Changing the Treatment Paradigm in Solid Tumors: What Advanced Practitioners in Oncology Need to Know.
Marianne Davies.
J Adv Pract Oncol, 2016 Jul 01; 7(5). PMID: 29282426    Free PMC article.
Cancer Immunotherapy and Personalized Medicine: Emerging Technologies and Biomarker-Based Approaches.
Laura Maciejko, Munisha Smalley, Aaron Goldman.
J Mol Biomark Diagn, 2017 Dec 30; 8(5). PMID: 29285416    Free PMC article.
Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models.
Katherine E Lewis, Mark J Selby, +11 authors, Stacey R Dillon.
Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296539    Free PMC article.
Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade.
Jie Bai, Zhitao Gao, +3 authors, Jing Nie.
Oncotarget, 2018 Jan 05; 8(66). PMID: 29299180    Free PMC article.
Improving immune-vascular crosstalk for cancer immunotherapy.
Yuhui Huang, Betty Y S Kim, +3 authors, Wen Jiang.
Nat Rev Immunol, 2018 Jan 16; 18(3). PMID: 29332937    Free PMC article.
Highly Cited. Review.
LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer.
Masoud F Tavazoie, Ilana Pollack, +21 authors, Sohail F Tavazoie.
Cell, 2018 Jan 18; 172(4). PMID: 29336888    Free PMC article.
Highly Cited.
Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade.
Charlotte E Ariyan, Mary Sue Brady, +19 authors, James P Allison.
Cancer Immunol Res, 2018 Jan 18; 6(2). PMID: 29339377    Free PMC article.
Clinical Development of PD-1 in Advanced Melanoma.
Rodrigo Ramella Munhoz, Michael Andrew Postow.
Cancer J, 2018 Jan 24; 24(1). PMID: 29360722    Free PMC article.
The biology and management of non-small cell lung cancer.
Roy S Herbst, Daniel Morgensztern, Chris Boshoff.
Nature, 2018 Jan 25; 553(7689). PMID: 29364287
Highly Cited. Review.
Network-based co-expression analysis for exploring the potential diagnostic biomarkers of metastatic melanoma.
Li-Xin Wang, Yang Li, Guan-Zhi Chen.
PLoS One, 2018 Jan 30; 13(1). PMID: 29377892    Free PMC article.
Expected Paradigm Shift in Brain Metastases Therapy-Immune Checkpoint Inhibitors.
Vishal Jindal, Sorab Gupta.
Mol Neurobiol, 2018 Feb 01; 55(8). PMID: 29383686
Neurological Adverse Events Associated with Immune Checkpoint Inhibitors: Diagnosis and Management.
Christophoros Astaras, Rita de Micheli, +2 authors, Andreas F Hottinger.
Curr Neurol Neurosci Rep, 2018 Feb 03; 18(1). PMID: 29392441
Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa.
Kabir A Khan, Robert S Kerbel.
Nat Rev Clin Oncol, 2018 Feb 13; 15(5). PMID: 29434333
Highly Cited. Review.
Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice.
Xuexiang Du, Mingyue Liu, +8 authors, Pan Zheng.
Cell Res, 2018 Feb 22; 28(4). PMID: 29463898    Free PMC article.
Highly Cited.
A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy.
Xuexiang Du, Fei Tang, +14 authors, Yang Liu.
Cell Res, 2018 Feb 24; 28(4). PMID: 29472691    Free PMC article.
Highly Cited.
Importance of immune monitoring approaches and the use of immune checkpoints for the treatment of diffuse intrinsic pontine glioma: From bench to clinic and vice versa (Review).
Jorge Augusto Borin Scutti.
Int J Oncol, 2018 Feb 28; 52(4). PMID: 29484440    Free PMC article.
Immune Monitoring of Cancer Patients Prior to and During CTLA-4 or PD-1/PD-L1 Inhibitor Treatment.
Antje Tunger, Maximilian Kießler, +4 authors, Marc Schmitz.
Biomedicines, 2018 Mar 02; 6(1). PMID: 29494517    Free PMC article.
The Rationale and Emerging Use of Neoadjuvant Immune Checkpoint Blockade for Solid Malignancies.
Emily Z Keung, Esosa U Ukponmwan, Alexandria P Cogdill, Jennifer A Wargo.
Ann Surg Oncol, 2018 Mar 04; 25(7). PMID: 29500764    Free PMC article.
Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients.
Priyanka B Subrahmanyam, Zhiwan Dong, +7 authors, F Stephen Hodi.
J Immunother Cancer, 2018 Mar 08; 6(1). PMID: 29510697    Free PMC article.
Highly Cited.
The Modulatory Roles of N-glycans in T-Cell-Mediated Autoimmune Diseases.
Ming-Wei Chien, Shin-Huei Fu, +2 authors, Huey-Kang Sytwu.
Int J Mol Sci, 2018 Mar 09; 19(3). PMID: 29518037    Free PMC article.
Combination immunotherapies implementing adoptive T-cell transfer for advanced-stage melanoma.
Kendra C Foley, Michael I Nishimura, Tamson V Moore.
Melanoma Res, 2018 Mar 10; 28(3). PMID: 29521881    Free PMC article.
Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer.
Taylor T Chrisikos, Yifan Zhou, +3 authors, Haiyan S Li.
Mol Immunol, 2018 Mar 20; 110. PMID: 29549977    Free PMC article.
Immunotherapy for Merkel cell carcinoma: a turning point in patient care.
Isaac S Chan, Shailender Bhatia, Howard L Kaufman, Evan J Lipson.
J Immunother Cancer, 2018 Mar 24; 6(1). PMID: 29566749    Free PMC article.
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Frederick Arce Vargas, Andrew J S Furness, +32 authors, Sergio A Quezada.
Cancer Cell, 2018 Mar 27; 33(4). PMID: 29576375    Free PMC article.
Highly Cited.
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies.
Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946    Free PMC article.
Highly Cited. Review.
Immunotherapy for Breast Cancer: Current and Future Strategies.
Austin D Williams, Kyle K Payne, +4 authors, Julia Tchou.
Curr Surg Rep, 2018 Apr 17; 5. PMID: 29657904    Free PMC article.
TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.
Heng-Jia Liu, Patrick H Lizotte, +8 authors, Elizabeth P Henske.
JCI Insight, 2018 Apr 20; 3(8). PMID: 29669930    Free PMC article.
Integrative Pharmacology: Advancing Development of Effective Immunotherapies.
Mohammad Tabrizi, Daping Zhang, Vaishnavi Ganti, Glareh Azadi.
AAPS J, 2018 Apr 29; 20(4). PMID: 29704129
Immunotherapeutic interventions of Triple Negative Breast Cancer.
Zehuan Li, Yiran Qiu, +2 authors, Jin Wang.
J Transl Med, 2018 Jun 01; 16(1). PMID: 29848327    Free PMC article.
Improved sensitivity for detection of breast cancer by combination of miR-34a and tumor markers CA 15-3 or CEA.
Martin Zaleski, Makbule Kobilay, +7 authors, Stefan Holdenrieder.
Oncotarget, 2018 Jun 02; 9(32). PMID: 29854296    Free PMC article.
Tune Up In Situ Autovaccination against Solid Tumors with Oncolytic Viruses.
Teresa Nguyen, Naze G Avci, +2 authors, Hong Jiang.
Cancers (Basel), 2018 Jun 03; 10(6). PMID: 29857493    Free PMC article.
Therapeutic Antibodies for Myeloid Neoplasms-Current Developments and Future Directions.
Christian M Schürch.
Front Oncol, 2018 Jun 06; 8. PMID: 29868474    Free PMC article.
Immunotherapy in Breast Cancer: the New Frontier.
Zishuo I Hu, Heather L McArthur.
Curr Breast Cancer Rep, 2018 Jun 09; 10(2). PMID: 29881518    Free PMC article.
Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity.
David Wang, Jason Quiros, +12 authors, Michel DuPage.
Cell Rep, 2018 Jun 14; 23(11). PMID: 29898397    Free PMC article.
Highly Cited.
Tumor Regression and Cure Depends on Sustained Th1 Responses.
Min Dai, Ingegerd Hellstrom, +2 authors, Karl Erik Hellstrom.
J Immunother, 2018 Jun 19; 41(8). PMID: 29912725    Free PMC article.
Pediatric Cancer Immunotherapy: Opportunities and Challenges.
Mary Frances Wedekind, Nicholas L Denton, Chun-Yu Chen, Timothy P Cripe.
Paediatr Drugs, 2018 Jun 28; 20(5). PMID: 29948928    Free PMC article.
PD-L1, TIM-3, and CTLA-4 Blockade Fails To Promote Resistance to Secondary Infection with Virulent Strains of Toxoplasma gondii.
Samantha D Splitt, Scott P Souza, +4 authors, Kirk D C Jensen.
Infect Immun, 2018 Jul 04; 86(9). PMID: 29967089    Free PMC article.
Cancer Immune Therapy: Prognostic Significance and Implications for Therapy of PD-1 in BCG-Relapsing Bladder Cancer.
Neelam Mukherjee, Robert Svatek.
Ann Surg Oncol, 2018 Jul 05; 25(9). PMID: 29971674    Free PMC article.
Cancer immune checkpoint blockade therapy and its associated autoimmune cardiotoxicity.
Jiu-Cheng Zhang, Wei-Dong Chen, +6 authors, Hua Zhu.
Acta Pharmacol Sin, 2018 Jul 12; 39(11). PMID: 29991709    Free PMC article.
Immunotherapy for pancreatic cancer: Barriers and breakthroughs.
Robert J Torphy, Yuwen Zhu, Richard D Schulick.
Ann Gastroenterol Surg, 2018 Jul 14; 2(4). PMID: 30003190    Free PMC article.
Highly Cited. Review.
Microbial biomarkers for immune checkpoint blockade therapy against cancer.
Keishi Adachi, Koji Tamada.
J Gastroenterol, 2018 Jul 14; 53(9). PMID: 30003334    Free PMC article.
Phytosomal curcumin causes natural killer cell-dependent repolarization of glioblastoma (GBM) tumor-associated microglia/macrophages and elimination of GBM and GBM stem cells.
Sumit Mukherjee, Angela Fried, +4 authors, Probal Banerjee.
J Exp Clin Cancer Res, 2018 Jul 26; 37(1). PMID: 30041669    Free PMC article.
Pembrolizumab KEYNOTE-001: an adaptive study leading to accelerated approval for two indications and a companion diagnostic.
S P Kang, K Gergich, +4 authors, E H Rubin.
Ann Oncol, 2018 Jul 28; 28(6). PMID: 30052728    Free PMC article.
Treg Fragility: A Prerequisite for Effective Antitumor Immunity?
Abigail E Overacre-Delgoffe, Dario A A Vignali.
Cancer Immunol Res, 2018 Aug 03; 6(8). PMID: 30068755    Free PMC article.
Complex interplay between tumor microenvironment and cancer therapy.
Minhong Shen, Yibin Kang.
Front Med, 2018 Aug 12; 12(4). PMID: 30097962
Ipilimumab: A tale of twists and turns.
Dhiraj Abhyankar.
South Asian J Cancer, 2018 Aug 17; 7(3). PMID: 30112338    Free PMC article.
Ipilimumab in combination with nivolumab for the treatment of renal cell carcinoma.
Xin Gao, David F McDermott.
Expert Opin Biol Ther, 2018 Aug 21; 18(9). PMID: 30124333    Free PMC article.
High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors.
Jolanda Brummelman, Emilia M C Mazza, +10 authors, Enrico Lugli.
J Exp Med, 2018 Aug 30; 215(10). PMID: 30154266    Free PMC article.
Highly Cited.
Insights Into the Molecular Mechanisms of T Follicular Helper-Mediated Immunity and Pathology.
Lei Qin, Tayab C Waseem, +4 authors, Roza Nurieva.
Front Immunol, 2018 Aug 31; 9. PMID: 30158933    Free PMC article.
Strategies for Predicting Response to Checkpoint Inhibitors.
Roberta Zappasodi, Jedd D Wolchok, Taha Merghoub.
Curr Hematol Malig Rep, 2018 Aug 31; 13(5). PMID: 30159703    Free PMC article.
Neurologic immune-related adverse events associated with adjuvant ipilimumab: report of two cases.
Christine A Garcia, Alex El-Ali, +4 authors, Diwakar Davar.
J Immunother Cancer, 2018 Sep 02; 6(1). PMID: 30170622    Free PMC article.
Precision medicine in pediatric oncology.
Stefan E G Burdach, Mike-Andrew Westhoff, Maximilian Felix Steinhauser, Klaus-Michael Debatin.
Mol Cell Pediatr, 2018 Sep 02; 5(1). PMID: 30171420    Free PMC article.
Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.
Lee-Shing Chang, Romualdo Barroso-Sousa, +3 authors, Le Min.
Endocr Rev, 2018 Sep 06; 40(1). PMID: 30184160    Free PMC article.
When to consider alternatives to front-line immune therapies in metastatic melanoma.
Daniel Y Wang, Douglas B Johnson.
Melanoma Manag, 2017 May 01; 4(2). PMID: 30190906    Free PMC article.
Utility of ipilimumab in melanoma patients who progress on anti-PD-1 therapy.
Cesar E Ochoa, Richard W Joseph.
Melanoma Manag, 2018 Sep 08; 4(3). PMID: 30190917    Free PMC article.
Stochastic modeling of tumor progression and immune evasion.
Jason T George, Herbert Levine.
J Theor Biol, 2018 Sep 16; 458. PMID: 30218648    Free PMC article.
Personal history of infections and immunotherapy: Unexpected links and possible therapeutic opportunities.
Camille Jacqueline, Nathalie Bonnefoy, +2 authors, Benjamin Roche.
Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221066    Free PMC article.
TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM.
Alice L Hung, Russell Maxwell, +20 authors, Michael Lim.
Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221069    Free PMC article.
Highly Cited.
Targeting PVR (CD155) and its receptors in anti-tumor therapy.
Paola Kučan Brlić, Tihana Lenac Roviš, +3 authors, Stipan Jonjić.
Cell Mol Immunol, 2018 Oct 03; 16(1). PMID: 30275538    Free PMC article.
The intracellular signalosome of PD-L1 in cancer cells.
David Escors, María Gato-Cañas, +4 authors, Grazyna Kochan.
Signal Transduct Target Ther, 2018 Oct 03; 3. PMID: 30275987    Free PMC article.
Highly Cited. Review.
Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy.
Jinfang Zhang, Fabin Dang, Junming Ren, Wenyi Wei.
Trends Biochem Sci, 2018 Oct 06; 43(12). PMID: 30287140    Free PMC article.
Synthetic DNA-Encoded Monoclonal Antibody Delivery of Anti-CTLA-4 Antibodies Induces Tumor Shrinkage In Vivo.
Elizabeth K Duperret, Aspen Trautz, +10 authors, David B Weiner.
Cancer Res, 2018 Oct 06; 78(22). PMID: 30287678    Free PMC article.
Safety of combined PD-1 pathway inhibition and radiation therapy for non-small-cell lung cancer: A multicentric retrospective study from the GFPC.
Paul Lesueur, Alexandre Escande, +9 authors, Radj Gervais.
Cancer Med, 2018 Oct 13; 7(11). PMID: 30311424    Free PMC article.
Cancer immunotherapy in routine cost-effective cancer care?
Sir Marc Feldmann.
EMBO Mol Med, 2018 Oct 17; 10(11). PMID: 30322840    Free PMC article.
Immune-checkpoint inhibitors for combating T-cell dysfunction in cancer.
Ewelina Grywalska, Marcin Pasiarski, Stanisław Góźdź, Jacek Roliński.
Onco Targets Ther, 2018 Oct 17; 11. PMID: 30323625    Free PMC article.
[Mode of action, new targets and potential biomarkers in modern immunotherapy].
J Bedke, V Stühler, T Todenhöfer, A Stenzl.
Urologe A, 2018 Oct 24; 57(11). PMID: 30350128
Progress in Kidney Cancer Outcomes Through Collaboration, Innovation, and Discovery.
David F McDermott, Michael Carducci.
J Clin Oncol, 2018 Oct 30;. PMID: 30372393    Free PMC article.
Nobel committee honors tumor immunologists.
Anand Rotte, Gabriella D'Orazi, Madhuri Bhandaru.
J Exp Clin Cancer Res, 2018 Nov 01; 37(1). PMID: 30376854    Free PMC article.
Systemic Therapy for Hepatocellular Carcinoma: Latest Advances.
Masatoshi Kudo.
Cancers (Basel), 2018 Nov 02; 10(11). PMID: 30380773    Free PMC article.
Highly Cited. Review.
Profiling Immune Escape in Hodgkin's and Diffuse large B-Cell Lymphomas Using the Transcriptome and Immunostaining.
Sarah Péricart, Marie Tosolini, +10 authors, Camille Laurent.
Cancers (Basel), 2018 Nov 06; 10(11). PMID: 30384489    Free PMC article.
2018 Nobel Prize in physiology or medicine.
Mark J Smyth, Michele Wl Teng.
Clin Transl Immunology, 2018 Nov 06; 7(10). PMID: 30386598    Free PMC article.
An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion.
John D Klement, Amy V Paschall, +7 authors, Kebin Liu.
J Clin Invest, 2018 Nov 06; 128(12). PMID: 30395540    Free PMC article.
The 2018 Nobel Prize in medicine goes to cancer immunotherapy (editorial for BMC cancer).
Zong Sheng Guo.
BMC Cancer, 2018 Nov 13; 18(1). PMID: 30415640    Free PMC article.
Transformation of Old Concepts for a New Era of Cancer Immunotherapy: Cytokine Therapy and Cancer Vaccines as Combination Partners of PD1/PD-L1 Inhibitors.
Romualdo Barroso-Sousa, Patrick A Ott.
Curr Oncol Rep, 2018 Dec 01; 21(1). PMID: 30498900
Long-Lived Plasma Cells in Mice and Men.
Siggeir F Brynjolfsson, Linn Persson Berg, +4 authors, Ola Grimsholm.
Front Immunol, 2018 Dec 07; 9. PMID: 30505309    Free PMC article.
PD-L1 expression with immune-infiltrate evaluation and outcome prediction in melanoma patients treated with ipilimumab.
Gabriele Madonna, Carmen Ballesteros-Merino, +10 authors, Paolo A Ascierto.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524879    Free PMC article.
Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models.
Vassilis Genoud, Eliana Marinari, +5 authors, Paul R Walker.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524896    Free PMC article.
Immunological targets for cancer therapy: new recognition.
Michael R Shurin.
Immunotargets Ther, 2018 Dec 13; 7. PMID: 30538966    Free PMC article.
CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy.
Monika C Brunner-Weinzierl, Christopher E Rudd.
Front Immunol, 2018 Dec 14; 9. PMID: 30542345    Free PMC article.
Progresses and Perspectives of Anti-PD-1/PD-L1 Antibody Therapy in Head and Neck Cancers.
Bo Yang, Tingjun Liu, +4 authors, Jianbo Sun.
Front Oncol, 2018 Dec 14; 8. PMID: 30547012    Free PMC article.
Synthesis and Immunomodulatory Activity of Fluorine-Containing Bisphosphonates.
Satoshi Mizuta, Mohammed S O Tagod, +5 authors, Yoshimasa Tanaka.
ChemMedChem, 2019 Jan 15; 14(4). PMID: 30637982    Free PMC article.
Determination of human γδ T cell-mediated cytotoxicity using a non-radioactive assay system.
Mohammed S O Tagod, Satoshi Mizuta, +6 authors, Yoshimasa Tanaka.
J Immunol Methods, 2019 Jan 18; 466. PMID: 30654042    Free PMC article.
Nanotechnology and Immunotherapy in Ovarian Cancer: Tracing New Landscapes.
Bruna Corradetti, Simone Pisano, Robert Steven Conlan, Mauro Ferrari.
J Pharmacol Exp Ther, 2019 Feb 10; 370(3). PMID: 30737357    Free PMC article.
Targeting immune cells for cancer therapy.
Sin Yee Gun, Sharon Wei Ling Lee, Je Lin Sieow, Siew Cheng Wong.
Redox Biol, 2019 Mar 29; 25. PMID: 30917934    Free PMC article.
Highly Cited. Review.
Rheumatic complications in cancer patients treated with immune checkpoint inhibitors.
Kyung-Ann Lee, Hae-Rim Kim, So Young Yoon.
Korean J Intern Med, 2019 Apr 25; 34(6). PMID: 31014065    Free PMC article.
Application of PD-1 Blockade in Cancer Immunotherapy.
Xiaomo Wu, Zhongkai Gu, +4 authors, Xiaolong Liu.
Comput Struct Biotechnol J, 2019 Jun 18; 17. PMID: 31205619    Free PMC article.
Highly Cited. Review.
pH-sensitive anti-CTLA4 antibodies: yes to efficacy, no to toxicity.
Amnon Altman, Kok-Fai Kong.
Cell Res, 2019 Jul 14; 29(8). PMID: 31300731    Free PMC article.
Immunotherapy for pediatric brain tumors: past and present.
Jessica B Foster, Peter J Madsen, +6 authors, Angela J Waanders.
Neuro Oncol, 2019 Sep 11; 21(10). PMID: 31504801    Free PMC article.
Cardiotoxicity from immune checkpoint inhibitors.
Lars Michel, Tienush Rassaf, Matthias Totzeck.
Int J Cardiol Heart Vasc, 2019 Sep 14; 25. PMID: 31517036    Free PMC article.
Selective inhibition of low-affinity memory CD8+ T cells by corticosteroids.
Akihiro Tokunaga, Daisuke Sugiyama, +7 authors, Hiroyoshi Nishikawa.
J Exp Med, 2019 Sep 21; 216(12). PMID: 31537643    Free PMC article.
Monoclonal Antibodies in Dermatooncology-State of the Art and Future Perspectives.
Malgorzata Bobrowicz, Radoslaw Zagozdzon, +3 authors, Magdalena Winiarska.
Cancers (Basel), 2019 Sep 27; 11(10). PMID: 31554169    Free PMC article.
Fucosylated α1-acid glycoprotein as a biomarker to predict prognosis following tumor immunotherapy of patients with lung cancer.
Takehiko Yokobori, Shin Yazawa, +6 authors, Ken Shirabe.
Sci Rep, 2019 Oct 12; 9(1). PMID: 31601857    Free PMC article.
CTLA-4 Immunohistochemistry and Quantitative Image Analysis for Profiling of Human Cancers.
Charles Brown, Farzad Sekhavati, +4 authors, Keith E Steele.
J Histochem Cytochem, 2019 Oct 15; 67(12). PMID: 31609157    Free PMC article.
Immunopathogenesis of Immune Checkpoint Inhibitor-Related Adverse Events: Roles of the Intestinal Microbiome and Th17 Cells.
Ronald Anderson, Annette J Theron, Bernardo L Rapoport.
Front Immunol, 2019 Oct 17; 10. PMID: 31616428    Free PMC article.
Suppressing immunotherapy by organ-specific tumor microenvironments: what is in the brain?
Chenyu Zhang, Dihua Yu.
Cell Biosci, 2019 Oct 19; 9. PMID: 31624532    Free PMC article.
Immune checkpoint inhibitors in mCRPC - rationales, challenges and perspectives.
H Taghizadeh, M Marhold, +3 authors, M Krainer.
Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646092    Free PMC article.
Immunotherapy in HER2-positive breast cancer: state of the art and future perspectives.
E Krasniqi, G Barchiesi, +17 authors, P Vici.
J Hematol Oncol, 2019 Oct 31; 12(1). PMID: 31665051    Free PMC article.
Demystifying Cancer Immunotherapy for Lay Audiences.
Kiara Ellis, Christopher A Pennell.
Front Immunol, 2019 Nov 05; 10. PMID: 31681338    Free PMC article.
Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4.
Shuang Qin, Linping Xu, +3 authors, Suxia Luo.
Mol Cancer, 2019 Nov 07; 18(1). PMID: 31690319    Free PMC article.
Highly Cited. Review.
The First Year of HemaSphere and Many More to Come.
Andreas Engert, Jan Cools.
Hemasphere, 2019 Nov 15; 2(6). PMID: 31723799    Free PMC article.
Innovative oncology products: time to revisit the strategy development?
Andriy Krendyukov.
ESMO Open, 2019 Nov 22; 4(5). PMID: 31749992    Free PMC article.
Analysis of key clinical features for achieving complete remission in stage III and IV non-small cell lung cancer patients.
Takuya Aoki, Takeshi Akiba, +21 authors, Koichiro Asano.
Respir Res, 2019 Nov 23; 20(1). PMID: 31752884    Free PMC article.
Cancer immune escape: MHC expression in primary tumours versus metastases.
Federico Garrido, Natalia Aptsiauri.
Immunology, 2019 Sep 12; 158(4). PMID: 31509607    Free PMC article.
Neoantigens and genome instability: impact on immunogenomic phenotypes and immunotherapy response.
Elaine R Mardis.
Genome Med, 2019 Nov 22; 11(1). PMID: 31747945    Free PMC article.
Setting the scene - a future 'epidemic' of immune-related adverse events in association with checkpoint inhibitor therapy.
Maria V Bermudez, Sophie Papa.
Rheumatology (Oxford), 2019 Dec 10; 58(Suppl 7). PMID: 31816083    Free PMC article.
MicroRNA regulation of CD8+ T cell responses.
John D Gagnon, K Mark Ansel.
Noncoding RNA Investig, 2019 Dec 18; 3. PMID: 31844841    Free PMC article.
Natural Products and Synthetic Analogs as a Source of Antitumor Drugs.
Javad Sharifi-Rad, Adem Ozleyen, +8 authors, William C Cho.
Biomolecules, 2019 Nov 07; 9(11). PMID: 31683894    Free PMC article.
Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer.
Katsiaryna Marhelava, Zofia Pilch, +2 authors, Radoslaw Zagozdzon.
Cancers (Basel), 2019 Nov 14; 11(11). PMID: 31717326    Free PMC article.
Discovery of Small Molecules for the Reversal of T Cell Exhaustion.
Brett S Marro, Jaroslav Zak, +3 authors, Michael B A Oldstone.
Cell Rep, 2019 Dec 05; 29(10). PMID: 31801090    Free PMC article.
The "Achilles' Heel" of Cancer and Its Implications for the Development of Novel Immunotherapeutic Strategies.
Kroopa Joshi, Benjamin M Chain, Karl S Peggs, Sergio A Quezada.
Cold Spring Harb Perspect Med, 2017 Jun 21; 8(1). PMID: 28630228    Free PMC article.
Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy.
Yan Zhang, Xuexiang Du, +9 authors, Yang Liu.
Cell Res, 2019 Jul 04; 29(8). PMID: 31267017    Free PMC article.
Immunotherapy for advanced melanoma.
Lei Fang, Anke S Lonsdorf, Sam T Hwang.
J Invest Dermatol, 2008 Oct 18; 128(11). PMID: 18927541    Free PMC article.
T-Regulatory Cells In Tumor Progression And Therapy.
Amit Verma, Rohit Mathur, +3 authors, Bilikere S Dwarakanath.
Cancer Manag Res, 2020 Jan 11; 11. PMID: 31920383    Free PMC article.
The Intriguing History of Cancer Immunotherapy.
Paula Dobosz, Tomasz Dzieciątkowski.
Front Immunol, 2020 Jan 11; 10. PMID: 31921205    Free PMC article.
Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging.
Ziming Du, Jia-Ren Lin, +6 authors, Sandro Santagata.
Nat Protoc, 2019 Sep 20; 14(10). PMID: 31534232    Free PMC article.
Combined induction with anti-PD-1 and anti-CTLA-4 antibodies provides synergistic antitumor effects in DC-CIK cells in renal carcinoma cell lines.
Zhaohu Yuan, Huikuan Yang, Yaming Wei.
Int J Clin Exp Pathol, 2020 Jan 15; 12(1). PMID: 31933726    Free PMC article.
Amplifying Outcomes: Checkpoint Inhibitor Combinations in First-Line Non-Small Cell Lung Cancer.
Barbara Melosky, Rosalyn Juergens, +5 authors, Quincy Chu.
Oncologist, 2019 May 30; 25(1). PMID: 31138727    Free PMC article.
Peptide-based targeting of immunosuppressive cells in cancer.
Noah T Trac, Eun Ji Chung.
Bioact Mater, 2020 Jan 21; 5(1). PMID: 31956738    Free PMC article.
Fast and fierce versus slow and smooth: Heterogeneity in immune responses to Plasmodium in the controlled human malaria infection model.
Xi Zen Yap, Matthew B B McCall, Robert W Sauerwein.
Immunol Rev, 2019 Oct 13; 293(1). PMID: 31605396    Free PMC article.
Immunotherapy in Pediatric Solid Tumors-A Systematic Review.
Raoud Marayati, Colin H Quinn, Elizabeth A Beierle.
Cancers (Basel), 2019 Dec 19; 11(12). PMID: 31847387    Free PMC article.
Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance.
Tijana Martinov, Brian T Fife.
Ann N Y Acad Sci, 2019 Apr 27; 1461(1). PMID: 31025378    Free PMC article.
Microenvironment-Dependent Gradient of CTL Exhaustion in the AE17sOVA Murine Mesothelioma Tumor Model.
Jennifer L Hope, Panagiota I Spantidea, +9 authors, Peter D Katsikis.
Front Immunol, 2020 Jan 31; 10. PMID: 31998326    Free PMC article.
Determining macrophage versus neutrophil contributions to innate immunity using larval zebrafish.
Emily E Rosowski.
Dis Model Mech, 2020 Jan 15; 13(1). PMID: 31932292    Free PMC article.
Inter-tumor heterogeneity of PD-L1 expression in non-small cell lung cancer.
Yuichi Saito, Sho Horiuchi, +5 authors, Eishin Hoshi.
J Thorac Dis, 2020 Feb 08; 11(12). PMID: 32030214    Free PMC article.
Upcoming Revolutionary Paths in Preclinical Modeling of Pancreatic Adenocarcinoma.
Mirna Swayden, Philippe Soubeyran, Juan Iovanna.
Front Oncol, 2020 Feb 11; 9. PMID: 32038993    Free PMC article.
Paradox-driven adventures in the development of cancer immunology and immunotherapy.
Whitney Barham, Joanina K Gicobi, +2 authors, Haidong Dong.
Genes Dis, 2020 Feb 12; 6(3). PMID: 32042862    Free PMC article.
Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies.
Hongxing Shen, Eddy Shih-Hsin Yang, +4 authors, Lewis Zhichang Shi.
Genes Dis, 2020 Feb 12; 6(3). PMID: 32042863    Free PMC article.
The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer.
Isabel Alvarado-Cruz, Rithy Meas, +3 authors, Joann Balazs Sweasy.
Mutagenesis, 2019 Dec 28; 35(1). PMID: 31880305    Free PMC article.
Tumor mutational burden as a predictive biomarker for checkpoint inhibitor immunotherapy.
Mark Lee, Robert M Samstein, +2 authors, Luc G T Morris.
Hum Vaccin Immunother, 2019 Jul 31; 16(1). PMID: 31361563    Free PMC article.
B7-1 drives TGF-β stimulated pancreatic carcinoma cell migration and expression of EMT target genes.
Jeong-Han Kang, Mi-Yeon Jung, Edward B Leof.
PLoS One, 2019 Sep 05; 14(9). PMID: 31483844    Free PMC article.
Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells.
Matthew B Dong, Guangchuan Wang, +17 authors, Sidi Chen.
Cell, 2019 Aug 24; 178(5). PMID: 31442407    Free PMC article.
The route of administration dictates the immunogenicity of peptide-based cancer vaccines in mice.
Hussein Sultan, Takumi Kumai, +3 authors, Esteban Celis.
Cancer Immunol Immunother, 2019 Jan 04; 68(3). PMID: 30604041    Free PMC article.
Immunotherapy in Gastrointestinal Cancer: Where Do We Stand?
Andrea Tannapfel, Anke Reinacher-Schick.
Visc Med, 2019 Jul 18; 35(1). PMID: 31312643    Free PMC article.
Immunotherapy: Pancreatic Cancer and Extrahepatic Biliary Tract Cancer.
Lukas Perkhofer, Alica K Beutel, Thomas J Ettrich.
Visc Med, 2019 Jul 18; 35(1). PMID: 31312647    Free PMC article.
PD-L1 Inhibitor-Induced Thyroiditis Is Associated with Better Overall Survival in Cancer Patients.
Anupam Kotwal, Lisa Kottschade, Mabel Ryder.
Thyroid, 2019 Dec 10; 30(2). PMID: 31813343    Free PMC article.
Structure and Optimization of Checkpoint Inhibitors.
Sarah L Picardo, Jeffrey Doi, Aaron R Hansen.
Cancers (Basel), 2019 Dec 28; 12(1). PMID: 31877721    Free PMC article.
Efficacy and safety of immune checkpoint inhibitors in advanced gastric or gastroesophageal junction cancer: a systematic review and meta-analysis.
Cong Chen, Fan Zhang, +7 authors, Yu-Min Li.
Oncoimmunology, 2019 May 10; 8(5). PMID: 31069144    Free PMC article.
Immune checkpoint modulation enhances HIV-1 antibody induction.
Todd Bradley, Masayuki Kuraoka, +27 authors, Barton F Haynes.
Nat Commun, 2020 Feb 23; 11(1). PMID: 32075963    Free PMC article.
Insights Into Lung Cancer Immune-Based Biology, Prevention, and Treatment.
Sara Saab, Hussein Zalzale, +3 authors, Humam Kadara.
Front Immunol, 2020 Mar 03; 11. PMID: 32117295    Free PMC article.
TLR1/2 ligand enhances antitumor efficacy of CTLA-4 blockade by increasing intratumoral Treg depletion.
Naveen Sharma, Jean Vacher, James P Allison.
Proc Natl Acad Sci U S A, 2019 May 12; 116(21). PMID: 31076558    Free PMC article.
Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma.
Megumi Goto, Kenji Chamoto, +17 authors, Tasuku Honjo.
Sci Rep, 2019 Jul 14; 9(1). PMID: 31300681    Free PMC article.
Preclinical mouse solid tumour models: status quo, challenges and perspectives.
Nicolas Gengenbacher, Mahak Singhal, Hellmut G Augustin.
Nat Rev Cancer, 2017 Oct 28; 17(12). PMID: 29077691
Highly Cited. Review.
CTLA-4: a moving target in immunotherapy.
Behzad Rowshanravan, Neil Halliday, David M Sansom.
Blood, 2017 Nov 10; 131(1). PMID: 29118008    Free PMC article.
Highly Cited. Review.
Functional genomics: paving the way for more successful cancer immunotherapy.
Reham Ajina, Danielle Zamalin, Louis M Weiner.
Brief Funct Genomics, 2018 May 16; 18(2). PMID: 29762641    Free PMC article.
Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers.
Anu Sharma, Sumit K Subudhi, +6 authors, Padmanee Sharma.
Clin Cancer Res, 2018 Jul 29; 25(4). PMID: 30054281    Free PMC article.
Highly Cited.
Principles of adoptive T cell therapy in cancer.
Özcan Met, Kasper Mølgaard Jensen, +2 authors, Inge Marie Svane.
Semin Immunopathol, 2018 Sep 07; 41(1). PMID: 30187086
Improved Cancer Immunochemotherapy via Optimal Co-delivery of Chemotherapeutic and Immunomodulatory Agents.
Yichao Chen, Jingjing Sun, +2 authors, Song Li.
Mol Pharm, 2018 Sep 18; 15(11). PMID: 30222360    Free PMC article.
The challenges of checkpoint inhibition in the treatment of multiple myeloma.
Barry Paul, Shuqi Kang, Zhihong Zheng, Yubin Kang.
Cell Immunol, 2018 Oct 22; 334. PMID: 30342750    Free PMC article.
High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy.
Matthew M Gubin, Ekaterina Esaulova, +16 authors, Maxim N Artyomov.
Cell, 2018 Oct 23; 175(4). PMID: 30343900    Free PMC article.
Highly Cited.
Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic.
T A Chan, M Yarchoan, +4 authors, S Peters.
Ann Oncol, 2018 Nov 06; 30(1). PMID: 30395155    Free PMC article.
Highly Cited. Review.
Immunotherapy transforms cancer treatment.
Neeha Zaidi, Elizabeth M Jaffee.
J Clin Invest, 2018 Dec 07; 129(1). PMID: 30507614    Free PMC article.
Antibodies to watch in 2019.
Hélène Kaplon, Janice M Reichert.
MAbs, 2018 Dec 06; 11(2). PMID: 30516432    Free PMC article.
Highly Cited.
Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity.
Chien-Chun Steven Pai, Donald M Simons, +22 authors, Lawrence Fong.
J Clin Invest, 2018 Dec 12; 129(1). PMID: 30530991    Free PMC article.
Combination Strategies to Optimize Efficacy of Dendritic Cell-Based Immunotherapy.
Mandy van Gulijk, Floris Dammeijer, Joachim G J V Aerts, Heleen Vroman.
Front Immunol, 2018 Dec 21; 9. PMID: 30568653    Free PMC article.
Recent updates in cancer immunotherapy: a comprehensive review and perspective of the 2018 China Cancer Immunotherapy Workshop in Beijing.
Zihai Li, Wenru Song, Mark Rubinstein, Delong Liu.
J Hematol Oncol, 2018 Dec 24; 11(1). PMID: 30577797    Free PMC article.
Highly Cited. Review.
Role of miRNAs in immune responses and immunotherapy in cancer.
Maria Angelica Cortez, Simone Anfossi, +5 authors, George A Calin.
Genes Chromosomes Cancer, 2018 Dec 24; 58(4). PMID: 30578699    Free PMC article.
Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries.
Mohamed S Abdel-Hakeem.
Viruses, 2019 Jan 30; 11(2). PMID: 30691215    Free PMC article.
Immunotherapy for skin cancer.
Kelly G Paulson, Miranda C Lahman, Aude G Chapuis, Isaac Brownell.
Int Immunol, 2019 Feb 13; 31(7). PMID: 30753483    Free PMC article.
Advances in immunotherapy delivery from implantable and injectable biomaterials.
David G Leach, Simon Young, Jeffrey D Hartgerink.
Acta Biomater, 2019 Feb 17; 88. PMID: 30771535    Free PMC article.
The Emerging World of TCR-T Cell Trials Against Cancer: A Systematic Review.
Jianxiang Zhang, Lingyu Wang.
Technol Cancer Res Treat, 2019 Feb 26; 18. PMID: 30798772    Free PMC article.
Highly Cited. Systematic Review.
High Expression of HLA-G in Ovarian Carcinomatosis: The Role of Interleukin-1β.
Matti Ullah, Dallel Azazzen, +4 authors, Massoud Mirshahi.
Neoplasia, 2019 Feb 26; 21(3). PMID: 30802770    Free PMC article.
PD-1/PD-L1 Blockade Therapy in Advanced Non-Small-Cell Lung Cancer: Current Status and Future Directions.
Liliang Xia, Yuanyong Liu, Ying Wang.
Oncologist, 2019 Mar 02; 24(Suppl 1). PMID: 30819829    Free PMC article.
Immune checkpoint inhibitors: an emerging cause of insulin-dependent diabetes.
Anupam Kotwal, Candace Haddox, Matthew Block, Yogish C Kudva.
BMJ Open Diabetes Res Care, 2019 Mar 23; 7(1). PMID: 30899528    Free PMC article.
Highly Cited.
Dynamic host immune response in virus-associated cancers.
Song Cao, Kristine M Wylie, +13 authors, Li Ding.
Commun Biol, 2019 Mar 27; 2. PMID: 30911684    Free PMC article.
Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota.
Arthur E Frankel, Sachin Deshmukh, +8 authors, Andrew Y Koh.
Integr Cancer Ther, 2019 Apr 25; 18. PMID: 31014119    Free PMC article.
Emerging therapies for small cell lung cancer.
Sen Yang, Zhe Zhang, Qiming Wang.
J Hematol Oncol, 2019 May 03; 12(1). PMID: 31046803    Free PMC article.
Highly Cited. Review.
Intratumoral regulatory T cells: markers, subsets and their impact on anti-tumor immunity.
Hiroshi Yano, Lawrence P Andrews, Creg J Workman, Dario A A Vignali.
Immunology, 2019 May 16; 157(3). PMID: 31087644    Free PMC article.
Highly Cited. Review.
Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D.
Peter S Linsley, S Alice Long.
Curr Opin Endocrinol Diabetes Obes, 2019 Jun 04; 26(4). PMID: 31157632    Free PMC article.
Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies.
Hao Wang, Gurbakhash Kaur, +3 authors, Xingxing Zang.
J Hematol Oncol, 2019 Jun 13; 12(1). PMID: 31186046    Free PMC article.
Generating viable mice with heritable embryonically lethal mutations using the CRISPR-Cas9 system in two-cell embryos.
Yi Wu, Jing Zhang, +11 authors, Songlin Wang.
Nat Commun, 2019 Jun 30; 10(1). PMID: 31253768    Free PMC article.
Macrophage-Mediated Subversion of Anti-Tumour Immunity.
Valeria Quaranta, Michael C Schmid.
Cells, 2019 Jul 25; 8(7). PMID: 31331034    Free PMC article.
Neoantigen vaccine: an emerging tumor immunotherapy.
Miao Peng, Yongzhen Mo, +10 authors, Zhaoyang Zeng.
Mol Cancer, 2019 Aug 25; 18(1). PMID: 31443694    Free PMC article.
Highly Cited. Review.
Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers.
Yves Lecarpentier, Olivier Schussler, Jean-Louis Hébert, Alexandre Vallée.
Front Oncol, 2019 Dec 06; 9. PMID: 31803621    Free PMC article.
Immunotherapy and targeted therapy-the new roadmap in cancer treatment.
Kamran Shahid, Mustafa Khalife, Raetasha Dabney, Alexandria T Phan.
Ann Transl Med, 2019 Dec 07; 7(20). PMID: 31807576    Free PMC article.
Cancer Nano-Immunotherapy from the Injection to the Target: The Role of Protein Corona.
Idoia Mikelez-Alonso, Antonio Aires, Aitziber L Cortajarena.
Int J Mol Sci, 2020 Jan 18; 21(2). PMID: 31947622    Free PMC article.
Immunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges.
Kei Kunimasa, Taichiro Goto.
Int J Mol Sci, 2020 Jan 23; 21(2). PMID: 31963413    Free PMC article.
Immunotherapy Outcomes in Advanced Melanoma in Relation to Age.
Krishna Joshi, Dinesh Atwal, +6 authors, Fade Mahmoud.
Perm J, 2020 Feb 26; 24. PMID: 32097116    Free PMC article.
A phase II open label, randomised study of ipilimumab with temozolomide versus temozolomide alone after surgery and chemoradiotherapy in patients with recently diagnosed glioblastoma: the Ipi-Glio trial protocol.
Nicholas F Brown, Stasya M Ng, +8 authors, Paul Mulholland.
BMC Cancer, 2020 Mar 14; 20(1). PMID: 32164579    Free PMC article.
Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours.
Ellen Brenner, Barbara F Schörg, +32 authors, Martin Röcken.
Nat Commun, 2020 Mar 14; 11(1). PMID: 32165639    Free PMC article.
Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.
Yu Chao, Chao Liang, +11 authors, Zhuang Liu.
Sci Adv, 2020 Mar 18; 6(10). PMID: 32181368    Free PMC article.
Targeting CD47 as a Novel Immunotherapy for Multiple Myeloma.
Jennifer Sun, Barbara Muz, +11 authors, Abdel Kareem Azab.
Cancers (Basel), 2020 Feb 06; 12(2). PMID: 32012878    Free PMC article.
Ipilimumab and Its Derived EGFR Aptamer-Based Conjugate Induce Efficient NK Cell Activation against Cancer Cells.
Margherita Passariello, Simona Camorani, +3 authors, Claudia De Lorenzo.
Cancers (Basel), 2020 Feb 07; 12(2). PMID: 32024070    Free PMC article.
An unexpected turn of fortune: targeting TRAIL-Rs in KRAS-driven cancer.
Silvia von Karstedt, Henning Walczak.
Cell Death Discov, 2020 Mar 21; 6. PMID: 32194994    Free PMC article.
The past, present, and future of costimulation blockade in organ transplantation.
Paul M Schroder, Zachary W Fitch, +3 authors, Stuart J Knechtle.
Curr Opin Organ Transplant, 2019 Jun 04; 24(4). PMID: 31157670    Free PMC article.
The role of T cell trafficking in CTLA-4 blockade-induced gut immunopathology.
Shashuang Zhang, Wenhua Liang, +2 authors, Feng Wang.
BMC Biol, 2020 Mar 19; 18(1). PMID: 32183814    Free PMC article.
Novel calreticulin-nanoparticle in combination with focused ultrasound induces immunogenic cell death in melanoma to enhance antitumor immunity.
Sri Nandhini Sethuraman, Mohit Pratap Singh, +6 authors, Ashish Ranjan.
Theranostics, 2020 Mar 25; 10(8). PMID: 32206098    Free PMC article.
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.
Qingsong Hu, Youqiong Ye, +34 authors, Liuqing Yang.
Nat Immunol, 2019 Jun 05; 20(7). PMID: 31160797    Free PMC article.
Highly Cited.
Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy.
Ryusuke Hatae, Kenji Chamoto, +13 authors, Tasuku Honjo.
JCI Insight, 2019 Dec 20; 5(2). PMID: 31855576    Free PMC article.
Mouse Systems Genetics as a Prelude to Precision Medicine.
Hao Li, Johan Auwerx.
Trends Genet, 2020 Feb 11; 36(4). PMID: 32037011    Free PMC article.
The risks of targeting co-inhibitory pathways to modulate pathogen-directed T cell responses.
Helge Frebel, Annette Oxenius.
Trends Immunol, 2013 Jan 22; 34(5). PMID: 23333205    Free PMC article.
Inhibition of SHP-1 Expands the Repertoire of Antitumor T Cells Available to Respond to Immune Checkpoint Blockade.
Jeremy P Snook, Ashleigh J Soedel, +2 authors, Matthew A Williams.
Cancer Immunol Res, 2020 Feb 23; 8(4). PMID: 32075800    Free PMC article.
Human monoclonal antibodies from transgenic mice.
N Lonberg.
Handb Exp Pharmacol, 2007 Dec 12; (181). PMID: 18071942    Free PMC article.
The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity.
Alexandra Schnell, Lloyd Bod, Asaf Madi, Vijay K Kuchroo.
Cell Res, 2020 Jan 25; 30(4). PMID: 31974523    Free PMC article.
Next-generation immuno-oncology agents: current momentum shifts in cancer immunotherapy.
Chongxian Pan, Hongtao Liu, +4 authors, Lei Zheng.
J Hematol Oncol, 2020 Apr 05; 13(1). PMID: 32245497    Free PMC article.
Development of immune checkpoint therapy for cancer.
Jill M Fritz, Michael J Lenardo.
J Exp Med, 2019 May 10; 216(6). PMID: 31068379    Free PMC article.
Highly Cited. Review.
Immunotherapy: From Advanced NSCLC to Early Stages, an Evolving Concept.
Thierry Berghmans, Valérie Durieux, Lizza E L Hendriks, Anne-Marie Dingemans.
Front Med (Lausanne), 2020 Apr 09; 7. PMID: 32266275    Free PMC article.
Systematic Review.
Can Immunogenic Chemotherapies Relieve Cancer Cell Resistance to Immune Checkpoint Inhibitors?
Thaiz Rivera Vargas, Lionel Apetoh.
Front Immunol, 2019 Jun 14; 10. PMID: 31191545    Free PMC article.
Rationale for Combining Radiotherapy and Immune Checkpoint Inhibition for Patients With Hypoxic Tumors.
Franziska Eckert, Kerstin Zwirner, +3 authors, Stephan M Huber.
Front Immunol, 2019 Apr 02; 10. PMID: 30930892    Free PMC article.
Autologous Hematopoietic Stem Cells Are a Preferred Source to Generate Dendritic Cells for Immunotherapy in Multiple Myeloma Patients.
Prajakta Shinde, Sameer Melinkeri, +2 authors, Lalita Limaye.
Front Immunol, 2019 Jun 06; 10. PMID: 31164886    Free PMC article.
The Tolerogenic Function of Regulatory T Cells in Pregnancy and Cancer.
Nanna Jørgensen, Gry Persson, Thomas Vauvert F Hviid.
Front Immunol, 2019 May 28; 10. PMID: 31134056    Free PMC article.
Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection.
Annarosaria De Vito, Paola Orecchia, +6 authors, Lorenzo Mortara.
Cancers (Basel), 2020 Mar 22; 12(3). PMID: 32197460    Free PMC article.
CD38 in Adenosinergic Pathways and Metabolic Re-programming in Human Multiple Myeloma Cells: In-tandem Insights From Basic Science to Therapy.
Alberto L Horenstein, Cristiano Bracci, Fabio Morandi, Fabio Malavasi.
Front Immunol, 2019 May 10; 10. PMID: 31068926    Free PMC article.
PD-L1 Distribution and Perspective for Cancer Immunotherapy-Blockade, Knockdown, or Inhibition.
Yilun Wu, Weiyu Chen, Zhi Ping Xu, Wenyi Gu.
Front Immunol, 2019 Sep 12; 10. PMID: 31507611    Free PMC article.
Highly Cited. Review.
Preponderance of CTLA4 Variation Associated With Autosomal Dominant Immune Dysregulation in the MYPPPY Motif.
Owen M Siggs, Amanda Russell, +6 authors, Christopher C Goodnow.
Front Immunol, 2019 Aug 10; 10. PMID: 31396201    Free PMC article.
Tuning the Tumor Myeloid Microenvironment to Fight Cancer.
Nadine S Jahchan, Adriana M Mujal, +4 authors, Matthew F Krummel.
Front Immunol, 2019 Aug 14; 10. PMID: 31402908    Free PMC article.
Mechanisms of checkpoint inhibition-induced adverse events.
P Urwyler, I Earnshaw, +9 authors, S Papa.
Clin Exp Immunol, 2020 Jan 29; 200(2). PMID: 31989585    Free PMC article.
Role of inflammasome activation in tumor immunity triggered by immune checkpoint blockers.
M Segovia, S Russo, +2 authors, M Hill.
Clin Exp Immunol, 2020 Apr 17; 200(2). PMID: 32297328    Free PMC article.
Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors.
Rachel Grosser, Leonid Cherkassky, Navin Chintala, Prasad S Adusumilli.
Cancer Cell, 2019 Nov 13; 36(5). PMID: 31715131    Free PMC article.
Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy.
Jun Wang, Jingwei Sun, +16 authors, Lieping Chen.
Nat Med, 2019 Mar 06; 25(4). PMID: 30833750    Free PMC article.
Highly Cited.
Sustained Coevolution in a Stochastic Model of Cancer-Immune Interaction.
Jason T George, Herbert Levine.
Cancer Res, 2019 Dec 22; 80(4). PMID: 31862779    Free PMC article.
Modeling clear cell renal cell carcinoma and therapeutic implications.
Melissa M Wolf, W Kimryn Rathmell, Kathryn E Beckermann.
Oncogene, 2020 Mar 04; 39(17). PMID: 32123314    Free PMC article.
Current Status of Immunotherapies for Treating Pancreatic Cancer.
Annie A Wu, Elizabeth Jaffee, Valerie Lee.
Curr Oncol Rep, 2019 May 19; 21(7). PMID: 31101991
Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy.
Ilenia Aversa, Donatella Malanga, Giuseppe Fiume, Camillo Palmieri.
Int J Mol Sci, 2020 Apr 03; 21(7). PMID: 32235561    Free PMC article.
T cell costimulation, checkpoint inhibitors and anti-tumor therapy.
Dipankar Nandi, Sanmoy Pathak, +6 authors, Vijayamahantesh.
J Biosci, 2020 Apr 30; 45. PMID: 32345776
Targeted Therapies Combined With Immune Checkpoint Therapy.
Peter A Prieto, Alexandre Reuben, Zachary A Cooper, Jennifer A Wargo.
Cancer J, 2016 Apr 26; 22(2). PMID: 27111910    Free PMC article.
Tumor Targeted Nanocarriers for Immunotherapy.
Alejandro Baeza.
Molecules, 2020 Apr 01; 25(7). PMID: 32225049    Free PMC article.
RIP3 promotes colitis-associated colorectal cancer by controlling tumor cell proliferation and CXCL1-induced immune suppression.
Zhen-Yu Liu, Ming Zheng, +9 authors, Zhi-Nan Chen.
Theranostics, 2019 Jul 10; 9(12). PMID: 31281505    Free PMC article.
IL36 Cooperates With Anti-CTLA-4 mAbs to Facilitate Antitumor Immune Responses.
Qiuxia Qu, Zhiwei Zhai, +3 authors, Binfeng Lu.
Front Immunol, 2020 May 01; 11. PMID: 32351508    Free PMC article.
Small molecule immunomodulation: the tumor microenvironment and overcoming immune escape.
Arsen Osipov, May Tun Saung, Lei Zheng, Adrian G Murphy.
J Immunother Cancer, 2019 Aug 24; 7(1). PMID: 31439034    Free PMC article.
Current issues and perspectives in PD-1 blockade cancer immunotherapy.
Kenji Chamoto, Ryusuke Hatae, Tasuku Honjo.
Int J Clin Oncol, 2020 Jan 05; 25(5). PMID: 31900651    Free PMC article.
A new hope.
R Wong.
Curr Oncol, 2020 May 06; 27(Suppl 2). PMID: 32368172    Free PMC article.
Species Classification for Neuroscience Literature Based on Span of Interest Using Sequence-to-Sequence Learning Model.
Hongyin Zhu, Yi Zeng, Dongsheng Wang, Cunqing Huangfu.
Front Hum Neurosci, 2020 May 07; 14. PMID: 32372933    Free PMC article.
Preserving the CTLA-4 Checkpoint for Safer and More Effective Cancer Immunotherapy.
Yang Liu, Pan Zheng.
Trends Pharmacol Sci, 2019 Dec 15; 41(1). PMID: 31836191    Free PMC article.
Evaluation of survival extrapolation in immuno-oncology using multiple pre-planned data cuts: learnings to aid in model selection.
Ash Bullement, Anna Willis, +3 authors, Murtuza Bharmal.
BMC Med Res Methodol, 2020 May 08; 20(1). PMID: 32375680    Free PMC article.
NK cells mediate clearance of CD8+ T cell-resistant tumors in response to STING agonists.
Christopher J Nicolai, Natalie Wolf, +5 authors, David H Raulet.
Sci Immunol, 2020 Mar 22; 5(45). PMID: 32198222    Free PMC article.
Exploiting immune-dependent effects of microtubule-targeting agents to improve efficacy and tolerability of cancer treatment.
Angela Flavia Serpico, Roberta Visconti, Domenico Grieco.
Cell Death Dis, 2020 May 14; 11(5). PMID: 32398657    Free PMC article.
Anti-PDL1 effect in squamous non-small cell lung cancer.
Mohamed Rahouma, Massimo Baudo, +2 authors, Nasser Altorki.
Transl Lung Cancer Res, 2020 May 19; 9(2). PMID: 32420083    Free PMC article.
Thymic Function Associated With Cancer Development, Relapse, and Antitumor Immunity - A Mini-Review.
Weikan Wang, Rachel Thomas, Olga Sizova, Dong-Ming Su.
Front Immunol, 2020 May 20; 11. PMID: 32425946    Free PMC article.
Talkin' Toxins: From Coley's to Modern Cancer Immunotherapy.
Robert D Carlson, John C Flickinger, Adam E Snook.
Toxins (Basel), 2020 Apr 15; 12(4). PMID: 32283684    Free PMC article.
microRNAs in the Antitumor Immune Response and in Bone Metastasis of Breast Cancer: From Biological Mechanisms to Therapeutics.
Marta Gomarasca, Paola Maroni, Giuseppe Banfi, Giovanni Lombardi.
Int J Mol Sci, 2020 Apr 23; 21(8). PMID: 32316552    Free PMC article.
A guide to cancer immunotherapy: from T cell basic science to clinical practice.
Alex D Waldman, Jill M Fritz, Michael J Lenardo.
Nat Rev Immunol, 2020 May 21; 20(11). PMID: 32433532    Free PMC article.
Nanotechnology Promotes Genetic and Functional Modifications of Therapeutic T Cells Against Cancer.
Ahmed M E Abdalla, Lin Xiao, +5 authors, Guang Yang.
Adv Sci (Weinh), 2020 May 23; 7(10). PMID: 32440473    Free PMC article.
The abscopal effect 67 years later: from a side story to center stage.
Sandra Demaria, Silvia C Formenti.
Br J Radiol, 2020 Feb 27; 93(1109). PMID: 32101479    Free PMC article.
The emerging role of epigenetic therapeutics in immuno-oncology.
Michael J Topper, Michelle Vaz, +2 authors, Stephen B Baylin.
Nat Rev Clin Oncol, 2019 Sep 25; 17(2). PMID: 31548600    Free PMC article.
Early prediction of pathologic response to neoadjuvant treatment of breast cancer: use of a cell-loss metric based on serum thymidine kinase 1 and tumour volume.
Bernhard Tribukait.
BMC Cancer, 2020 May 20; 20(1). PMID: 32423477    Free PMC article.
ST2 as checkpoint target for colorectal cancer immunotherapy.
Kevin Van der Jeught, Yifan Sun, +17 authors, Xiongbin Lu.
JCI Insight, 2020 May 08; 5(9). PMID: 32376804    Free PMC article.
Scientific Rationale for Combination Immunotherapy of Hepatocellular Carcinoma with Anti-PD-1/PD-L1 and Anti-CTLA-4 Antibodies.
Masatoshi Kudo.
Liver Cancer, 2020 Jun 02; 8(6). PMID: 32479569    Free PMC article.
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.
Louise van der Weyden, Agnieszka Swiatkowska, +2 authors, David J Adams.
G3 (Bethesda), 2020 Apr 05; 10(6). PMID: 32245826    Free PMC article.
The Role of Immune Checkpoints after Cellular Therapy.
Friederike Schmitz, Dominik Wolf, Tobias A W Holderried.
Int J Mol Sci, 2020 May 28; 21(10). PMID: 32455836    Free PMC article.
Preparation of Biphenyl-Conjugated Bromotyrosine for Inhibition of PD-1/PD-L1 Immune Checkpoint Interactions.
Eun-Hye Kim, Masuki Kawamoto, +3 authors, Hideyuki Miyatake.
Int J Mol Sci, 2020 May 28; 21(10). PMID: 32455628    Free PMC article.
The Cancer-Immune Set Point in Oesophageal Cancer.
Robert Power, Maeve A Lowery, John V Reynolds, Margaret R Dunne.
Front Oncol, 2020 Jun 26; 10. PMID: 32582553    Free PMC article.
Human cancer germline antigen-specific cytotoxic T cell-what can we learn from patient.
Megat Abd Hamid, Yanchun Peng, Tao Dong.
Cell Mol Immunol, 2020 May 27; 17(7). PMID: 32451453    Free PMC article.
Systemic therapy for advanced clear cell renal cell carcinoma after discontinuation of immune-oncology and VEGF targeted therapy combinations.
Yasser Ged, Ruby Gupta, +10 authors, Chung-Han Lee.
BMC Urol, 2020 Jul 04; 20(1). PMID: 32616076    Free PMC article.
Upregulation of Multiple CD8+ T Cell Exhaustion Pathways Is Associated with Recurrent Ocular Herpes Simplex Virus Type 1 Infection.
Pierre-Grégoire Coulon, Soumyabrata Roy, +12 authors, Lbachir BenMohamed.
J Immunol, 2020 Jun 17; 205(2). PMID: 32540992    Free PMC article.
Altering the response to radiation: radiosensitizers and targeted therapies in pancreatic ductal adenocarcinoma: preclinical and emerging clinical evidence.
Adam R Wolfe, Terence M Williams.
Ann Pancreat Cancer, 2018 Aug 01; 1(8). PMID: 32656528    Free PMC article.
Comprehensive review of targeted therapy for colorectal cancer.
Yuan-Hong Xie, Ying-Xuan Chen, Jing-Yuan Fang.
Signal Transduct Target Ther, 2020 Apr 17; 5(1). PMID: 32296018    Free PMC article.
PD-1: Its Discovery, Involvement in Cancer Immunotherapy, and Beyond.
Yasumasa Ishida.
Cells, 2020 Jun 05; 9(6). PMID: 32492969    Free PMC article.
Surface-Enhanced Raman Spectroscopy for Cancer Immunotherapy Applications: Opportunities, Challenges, and Current Progress in Nanomaterial Strategies.
Shuvashis Dey, Matt Trau, Kevin M Koo.
Nanomaterials (Basel), 2020 Jun 18; 10(6). PMID: 32545182    Free PMC article.
Prognostic value of immune checkpoint molecules in breast cancer.
Jun Fang, Feng Chen, +3 authors, Yuezhen Wang.
Biosci Rep, 2020 Jul 01; 40(7). PMID: 32602545    Free PMC article.
Radiation Dose Escalation is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance Local and Distant Antitumor Effect in Murine Osteosarcoma.
Wataru Takenaka, Yutaka Takahashi, +6 authors, Kazuhiko Ogawa.
Cancers (Basel), 2020 Jun 18; 12(6). PMID: 32545427    Free PMC article.
Immunological Targets for Immunotherapy: Inhibitory T Cell Receptors.
Diwakar Davar, Hassane M Zarour.
Methods Mol Biol, 2019 Sep 11; 2055. PMID: 31502146    Free PMC article.
Cancer immunotherapy using checkpoint blockade.
Antoni Ribas, Jedd D Wolchok.
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Highly Cited. Review.
Cutaneous melanoma and the immunotherapy revolution (Review).
Giulia C Leonardi, Saverio Candido, +2 authors, Massimo Libra.
Int J Oncol, 2020 Jun 26; 57(3). PMID: 32582963    Free PMC article.
Identification and validation of tumor microenvironment-related genes of prognostic value in lung adenocarcinoma.
Jingyan Yuan, Bo Yuan, +7 authors, Shuanying Yang.
Oncol Lett, 2020 Jul 30; 20(2). PMID: 32724420    Free PMC article.
The promise of combining cancer vaccine and checkpoint blockade for treating HPV-related cancer.
Takeo Shibata, Benjamin J Lieblong, Toshiyuki Sasagawa, Mayumi Nakagawa.
Cancer Treat Rev, 2019 Jul 16; 78. PMID: 31302573    Free PMC article.
Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10.
Shan-Shan Yin, Feng-Hou Gao.
Front Immunol, 2020 Aug 09; 11. PMID: 32765491    Free PMC article.
Cancer Cell Metabolism Bolsters Immunotherapy Resistance by Promoting an Immunosuppressive Tumor Microenvironment.
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Front Oncol, 2020 Aug 11; 10. PMID: 32775303    Free PMC article.
Immune Checkpoint Inhibitors and Immune-Related Adverse Renal Events.
Sandra M Herrmann, Mark A Perazella.
Kidney Int Rep, 2020 Aug 11; 5(8). PMID: 32775813    Free PMC article.
Necroptotic-susceptible dendritic cells exhibit enhanced antitumor activities in mice.
Zhanran Zhao, Guangzhi Zhang, Yuefang Sun, Astar Winoto.
Immun Inflamm Dis, 2020 Jul 15; 8(3). PMID: 32663380    Free PMC article.
Harnessing NK Cell Checkpoint-Modulating Immunotherapies.
Sachin Kumar Singh Chauhan, Ulrike Koehl, Stephan Kloess.
Cancers (Basel), 2020 Jul 10; 12(7). PMID: 32640575    Free PMC article.
Molecular Mechanisms and Potential Therapeutic Reversal of Pancreatic Cancer-Induced Immune Evasion.
Li-Lian Gan, Ling-Wei Hii, +2 authors, Chun-Wai Mai.
Cancers (Basel), 2020 Jul 16; 12(7). PMID: 32664564    Free PMC article.
Immune Checkpoint Inhibitors for Brain Metastases: A Primer for Neurosurgeons.
Elisa Aquilanti, Priscilla K Brastianos.
Neurosurgery, 2020 Apr 18; 87(3). PMID: 32302389    Free PMC article.
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications.
Yuanyuan Zhang, Zemin Zhang.
Cell Mol Immunol, 2020 Jul 03; 17(8). PMID: 32612154    Free PMC article.
A Review of T-Cell Related Therapy for Osteosarcoma.
Kazushige Yoshida, Masanori Okamoto, +2 authors, Naoto Saito.
Int J Mol Sci, 2020 Jul 16; 21(14). PMID: 32664248    Free PMC article.
B-cell epitope peptide cancer vaccines: a new paradigm for combination immunotherapies with novel checkpoint peptide vaccine.
Pravin Tp Kaumaya.
Future Oncol, 2020 Jun 23; 16(23). PMID: 32564612    Free PMC article.
Administration of low-dose combination anti-CTLA4, anti-CD137, and anti-OX40 into murine tumor or proximal to the tumor draining lymph node induces systemic tumor regression.
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Cancer Immunol Immunother, 2017 Sep 15; 67(1). PMID: 28905118    Free PMC article.
Advances in Anti-Cancer Immunotherapy: Car-T Cell, Checkpoint Inhibitors, Dendritic Cell Vaccines, and Oncolytic Viruses, and Emerging Cellular and Molecular Targets.
Emilie Alard, Aura-Bianca Butnariu, +5 authors, Md Zahidul Islam Pranjol.
Cancers (Basel), 2020 Jul 11; 12(7). PMID: 32645977    Free PMC article.
Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy.
Lukas Amon, Lukas Hatscher, +2 authors, Christian H K Lehmann.
Pharmaceutics, 2020 Jul 18; 12(7). PMID: 32674488    Free PMC article.
Nivolumab plus Ipilimumab versus Existing Immunotherapies in Patients with PD-L1-Positive Advanced Non-Small Cell Lung Cancer: A Systematic Review and Network Meta-Analysis.
Koichi Ando, Yasunari Kishino, +6 authors, Hironori Sagara.
Cancers (Basel), 2020 Jul 19; 12(7). PMID: 32679702    Free PMC article.
Strategies for Deliberate Induction of Immune Tolerance in Liver Transplantation: From Preclinical Models to Clinical Application.
Naoki Tanimine, Masahiro Ohira, +4 authors, Hideki Ohdan.
Front Immunol, 2020 Aug 28; 11. PMID: 32849546    Free PMC article.
Biological Landscape of Triple Negative Breast Cancers Expressing CTLA-4.
María G C Navarrete-Bernal, Mayte G Cervantes-Badillo, +14 authors, Leticia Rocha-Zavaleta.
Front Oncol, 2020 Aug 28; 10. PMID: 32850353    Free PMC article.
Scientifically based combination therapies with immuno-oncology checkpoint inhibitors.
Hui Yi Chew, Riccardo Dolcetti, Fiona Simpson.
Br J Clin Pharmacol, 2020 May 07; 86(9). PMID: 32372470    Free PMC article.
Immune checkpoint blockade in solid organ tumours: Choice, dose and predictors of response.
Vishal Navani, Moira C Graves, Nikola A Bowden, Andre Van Der Westhuizen.
Br J Clin Pharmacol, 2020 May 10; 86(9). PMID: 32384184    Free PMC article.
Combination of PD-L1 and PVR determines sensitivity to PD-1 blockade.
Bo Ryeong Lee, Sehyun Chae, +8 authors, Sang-Jun Ha.
JCI Insight, 2020 Jun 20; 5(14). PMID: 32554931    Free PMC article.
Human immunology and immunotherapy: main achievements and challenges.
Jezabel Varadé, Susana Magadán, África González-Fernández.
Cell Mol Immunol, 2020 Sep 04; 18(4). PMID: 32879472    Free PMC article.
Isolation of Two Novel Human Anti-CTLA-4 mAbs with Intriguing Biological Properties on Tumor and NK Cells.
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Cancers (Basel), 2020 Aug 13; 12(8). PMID: 32781690    Free PMC article.
Photoacoustic-immune therapy with a multi-purpose black phosphorus-based nanoparticle.
Fanchu Zeng, Huan Qin, +6 authors, Da Xing.
Nano Res, 2020 Sep 10;. PMID: 32904446    Free PMC article.
Combinatorial approach to cancer immunotherapy: strength in numbers.
Anna E Vilgelm, Douglas B Johnson, Ann Richmond.
J Leukoc Biol, 2016 Jun 04; 100(2). PMID: 27256570    Free PMC article.
Protein Footprinting and X-ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide.
Ben Niu, Todd C Appleby, +11 authors, Michael L Gross.
Biochemistry, 2019 Dec 17; 59(4). PMID: 31841311    Free PMC article.
TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy.
Martina Molgora, Ekaterina Esaulova, +18 authors, Marco Colonna.
Cell, 2020 Aug 14; 182(4). PMID: 32783918    Free PMC article.
Endocrine Adverse Events of Nivolumab in Non-Small Cell Lung Cancer Patients-Literature Review.
Marta Dudzińska, Michał Szczyrek, +3 authors, Agnieszka Zwolak.
Cancers (Basel), 2020 Aug 23; 12(8). PMID: 32824462    Free PMC article.
Generation of highly activated, antigen-specific tumor-infiltrating CD8+ T cells induced by a novel T cell-targeted immunotherapy.
Ava Vila-Leahey, Alecia MacKay, +3 authors, Marianne M Stanford.
Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923145    Free PMC article.
Mechanisms and microbial influences on CTLA-4 and PD-1-based immunotherapy in the treatment of cancer: a narrative review.
Peter L Miller, Tiffany L Carson.
Gut Pathog, 2020 Sep 19; 12. PMID: 32944086    Free PMC article.
Does the Immunocompetent Status of Cancer Patients Have an Impact on Therapeutic DC Vaccination Strategies?
Silvia Martin Lluesma, Michele Graciotti, Cheryl Lai-Lai Chiang, Lana E Kandalaft.
Vaccines (Basel), 2018 Nov 28; 6(4). PMID: 30477198    Free PMC article.
Current Options and Future Directions in Immune Therapy for Glioblastoma.
John Lynes, Victoria Sanchez, +2 authors, Edjah Nduom.
Front Oncol, 2018 Dec 21; 8. PMID: 30568917    Free PMC article.
2018 Nobel Prize in medicine awarded to cancer immunotherapy: Immune checkpoint blockade - A personal account.
Xingxing Zang.
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Radiation, Immune Checkpoint Blockade and the Abscopal Effect: A Critical Review on Timing, Dose and Fractionation.
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Front Oncol, 2019 Jan 09; 8. PMID: 30619752    Free PMC article.
Highly Cited. Review.
Cytokines, Chemokines, and Other Biomarkers of Response for Checkpoint Inhibitor Therapy in Skin Cancer.
Jennifer A Bridge, James C Lee, +2 authors, Jeffrey A Bluestone.
Front Med (Lausanne), 2019 Jan 12; 5. PMID: 30631766    Free PMC article.
Heart failure in cancer: role of checkpoint inhibitors.
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Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
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Oncoimmunology, 2019 Feb 05; 8(2). PMID: 30713785    Free PMC article.
Integrating Small Animal Irradiators withFunctional Imaging for Advanced Preclinical Radiotherapy Research.
Mihaela Ghita, Kathryn H Brown, +2 authors, Karl T Butterworth.
Cancers (Basel), 2019 Feb 06; 11(2). PMID: 30717307    Free PMC article.
Advances in immune checkpoint inhibitors for bone sarcoma therapy.
Pichaya Thanindratarn, Dylan C Dean, +2 authors, Zhenfeng Duan.
J Bone Oncol, 2019 Feb 19; 15. PMID: 30775238    Free PMC article.
Highly Cited. Review.
Immune checkpoint inhibitors: Advances and impact in neuro-oncology.
Jawad Fares, Mohamad Y Fares, Youssef Fares.
Surg Neurol Int, 2019 Feb 21; 10. PMID: 30783540    Free PMC article.
On the Other Side: Manipulating the Immune Checkpoint Landscape of Dendritic Cells to Enhance Cancer Immunotherapy.
Benjamin Y Kong, Holly Bolton, +3 authors, Georgina J Clark.
Front Oncol, 2019 Feb 23; 9. PMID: 30788290    Free PMC article.
Mouse-Derived Isograft (MDI) In Vivo Tumor Models I. Spontaneous sMDI Models: Characterization and Cancer Therapeutic Approaches.
Peter Jantscheff, Janette Beshay, +3 authors, Holger Weber.
Cancers (Basel), 2019 Feb 23; 11(2). PMID: 30791466    Free PMC article.
Functionalized Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as Platform for the Targeted Multimodal Tumor Therapy.
Christina Janko, Teresa Ratschker, +4 authors, Christoph Alexiou.
Front Oncol, 2019 Mar 01; 9. PMID: 30815389    Free PMC article.
Immune checkpoint inhibitor-induced colitis: A comprehensive review.
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World J Clin Cases, 2019 Mar 08; 7(4). PMID: 30842952    Free PMC article.
Highly Cited. Review.
Harnessing Radiation Biology to Augment Immunotherapy for Glioblastoma.
Karishma R Rajani, Lucas P Carlstrom, +3 authors, Terry C Burns.
Front Oncol, 2019 Mar 12; 8. PMID: 30854331    Free PMC article.
Risk and incidence of fatal adverse events associated with immune checkpoint inhibitors: a systematic review and meta-analysis.
Yi Jiang, Ning Zhang, +2 authors, Helong Zhang.
Ther Clin Risk Manag, 2019 Mar 13; 15. PMID: 30858709    Free PMC article.
Turning "Cold" Into "Hot" Tumors-Opportunities and Challenges for Radio-Immunotherapy Against Primary and Metastatic Brain Cancers.
Lisa Sevenich.
Front Oncol, 2019 Apr 04; 9. PMID: 30941312    Free PMC article.
Targeted Therapies and Immune-Checkpoint Inhibition in Head and Neck Squamous Cell Carcinoma: Where Do We Stand Today and Where to Go?
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Cancers (Basel), 2019 Apr 17; 11(4). PMID: 30987257    Free PMC article.
The Discovery of Biomarkers in Cancer Immunotherapy.
Anil P George, Timothy M Kuzel, Yi Zhang, Bin Zhang.
Comput Struct Biotechnol J, 2019 Apr 24; 17. PMID: 31011407    Free PMC article.
Immune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer Therapy.
Daniele Lecis, Sabina Sangaletti, Mario P Colombo, Claudia Chiodoni.
Cancers (Basel), 2019 May 08; 11(5). PMID: 31060225    Free PMC article.
Costimulatory and coinhibitory immune checkpoint receptors in head and neck cancer: unleashing immune responses through therapeutic combinations.
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Informatics and Computational Methods in Natural Product Drug Discovery: A Review and Perspectives.
Joseph D Romano, Nicholas P Tatonetti.
Front Genet, 2019 May 23; 10. PMID: 31114606    Free PMC article.
Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy.
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Biologics, 2019 May 24; 13. PMID: 31118560    Free PMC article.
Highly Cited. Review.
Expression of PD-1 and CTLA-4 Are Negative Prognostic Markers in Renal Cell Carcinoma.
Andreas Kahlmeyer, Christine G Stöhr, +5 authors, Franziska Erlmeier.
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Editorial: Management of Immune-Related Adverse Events for Patients Undergoing Treatment With Checkpoint Inhibitors.
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In silico simulation of a clinical trial with anti-CTLA-4 and anti-PD-L1 immunotherapies in metastatic breast cancer using a systems pharmacology model.
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R Soc Open Sci, 2019 Jun 21; 6(5). PMID: 31218069    Free PMC article.
Identification of hub genes and key pathways associated with angioimmunoblastic T-cell lymphoma using weighted gene co-expression network analysis.
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Cancer Manag Res, 2019 Jun 27; 11. PMID: 31239775    Free PMC article.
Combination pembrolizumab plus chemotherapy: a new standard of care for patients with advanced non-small-cell lung cancer.
Frank Weinberg, Shirish Gadgeel.
Lung Cancer (Auckl), 2019 Jun 27; 10. PMID: 31239797    Free PMC article.
Aging, Cancer and Immunity.
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J Cancer, 2019 Jul 10; 10(13). PMID: 31281479    Free PMC article.
Immunotherapy for hepatocellular carcinoma: recent advances and future perspectives.
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The Tumor Microenvironment in Colorectal Cancer Therapy.
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Immune checkpoint inhibitor-induced diarrhea/colitis: Endoscopic and pathologic findings.
Tsutomu Nishida, Hideki Iijima, Shiro Adachi.
World J Gastrointest Pathophysiol, 2019 Sep 29; 10(2). PMID: 31559106    Free PMC article.
Tissue Site and the Cancer Immunity Cycle.
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Interaction between Immunotherapy and Antiangiogenic Therapy for Cancer.
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Phage Display Derived Monoclonal Antibodies: From Bench to Bedside.
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Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1.
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TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals.
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Front Immunol, 2020 Oct 06; 11. PMID: 33013822    Free PMC article.
Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy.
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Monoclonal Antibodies in Cancer Therapy.
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Immune Checkpoints in Viral Infections.
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Advances in targeted therapy for esophageal cancer.
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Signal Transduct Target Ther, 2020 Oct 09; 5(1). PMID: 33028804    Free PMC article.
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Effectiveness of the combination of vascular targeted photodynamic therapy and anti-cytotoxic T-lymphocyte-associated antigen 4 in a preclinical mouse model of urothelial carcinoma.
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Near-Infrared Photoimmunotherapy Combined with CTLA4 Checkpoint Blockade in Syngeneic Mouse Cancer Models.
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Vaccines (Basel), 2020 Sep 18; 8(3). PMID: 32937841    Free PMC article.
Computational Verification of Large Logical Models-Application to the Prediction of T Cell Response to Checkpoint Inhibitors.
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RNA-electroporated T cells for cancer immunotherapy.
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Pharmacogenomics for immunotherapy and immune-related cardiotoxicity.
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A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer.
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The Tumor and Host Immune Signature, and the Gut Microbiota as Predictive Biomarkers for Immune Checkpoint Inhibitor Response in Melanoma Patients.
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Anti-PD1 and Anti-PDL1-Induced Hypophysitis: A Cohort Study of 17 Patients with Longitudinal Follow-Up.
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Immune Activation in Patients with Locally Advanced Cervical Cancer Treated with Ipilimumab Following Definitive Chemoradiation (GOG-9929).
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The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?
Rossana Franzin, Giuseppe Stefano Netti, +5 authors, Elena Ranieri.
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Epithelial-Mesenchymal Transition: Role in Cancer Progression and the Perspectives of Antitumor Treatment.
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Current Clinical Applications and Future Perspectives of Immune Checkpoint Inhibitors in Non-Hodgkin Lymphoma.
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Overcoming Tumor-Induced Immune Suppression: From Relieving Inhibition to Providing Costimulation with T Cell Agonists.
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Cancer cell metabolic reprogramming: a keystone for the response to immunotherapy.
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PD-1 Inhibitors: Do they have a Future in the Treatment of Glioblastoma?
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Will Next-Generation Immunotherapy Overcome the Intrinsic Diversity and Low Immunogenicity of Sarcomas to Improve Clinical Benefit?
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The Angiopoietin-2 and TIE Pathway as a Therapeutic Target for Enhancing Antiangiogenic Therapy and Immunotherapy in Patients with Advanced Cancer.
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Regulatory T Cells: From Discovery to Autoimmunity.
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Ipilimumab in prostate cancer.
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Non-conventional Inhibitory CD4+Foxp3-PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity.
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Highly Cited.
A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization.
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Highly Cited. Review.
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Combining PARP inhibition, radiation, and immunotherapy: A possible strategy to improve the treatment of cancer?
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The Era of Immune Checkpoint Therapy: From Cancer to Viral Infection-A Mini Comment on the 2018 Medicine Nobel Prize.
Jia Liu, Wen Pan, Dongliang Yang.
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Targeting Multiple Receptors to Increase Checkpoint Blockade Efficacy.
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Realizing the Clinical Potential of Immunogenic Cell Death in Cancer Chemotherapy and Radiotherapy.
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Highly Cited. Review.
RIG-I activating immunostimulatory RNA boosts the efficacy of anticancer vaccines and synergizes with immune checkpoint blockade.
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Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review.
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Highly Cited. Review.
<Editors' Choice> Meddling with meddlers: curbing regulatory T cells and augmenting antitumor immunity.
Vitaly Kochin, Hiroyoshi Nishikawa.
Nagoya J Med Sci, 2019 Apr 10; 81(1). PMID: 30962651    Free PMC article.
Clinical development of targeted and immune based anti-cancer therapies.
N A Seebacher, A E Stacy, G M Porter, A M Merlot.
J Exp Clin Cancer Res, 2019 Apr 13; 38(1). PMID: 30975211    Free PMC article.
Autoimmune Endocrine Dysfunctions Associated with Cancer Immunotherapies.
Silvia Martina Ferrari, Poupak Fallahi, +8 authors, Alessandro Antonelli.
Int J Mol Sci, 2019 May 30; 20(10). PMID: 31137683    Free PMC article.
Optimizing radiotherapy with immune checkpoint blockade in hepatocellular carcinoma.
Changhoon Choi, Gyu Sang Yoo, Won Kyung Cho, Hee Chul Park.
World J Gastroenterol, 2019 Jun 07; 25(20). PMID: 31171886    Free PMC article.
IgG based immunome analyses of breast cancer patients reveal underlying signaling pathways.
István Gyurján, Sandra Rosskopf, +3 authors, Andreas Weinhäusel.
Oncotarget, 2019 Jun 14; 10(37). PMID: 31191821    Free PMC article.
Combination of CTLA-4 and PD-1 blockers for treatment of cancer.
Anand Rotte.
J Exp Clin Cancer Res, 2019 Jun 15; 38(1). PMID: 31196207    Free PMC article.
Highly Cited. Review.
Genetic and genomic basis of the mismatch repair system involved in Lynch syndrome.
Kazuo Tamura, Motohide Kaneda, +5 authors, Junko Tatsumi-Miyajima.
Int J Clin Oncol, 2019 Jul 06; 24(9). PMID: 31273487
[Interstitial nephritis].
Anna Laura Herzog, Kai Lopau.
Internist (Berl), 2019 Jul 10; 60(8). PMID: 31286163
Can Allosteric Receptor-Protein Interactions in Receptor Complexes Be a Molecular Mechanism Involved in Cancer Immune Therapy?
Dasiel O Borroto-Escuela, Kjell Fuxe.
Front Endocrinol (Lausanne), 2019 Sep 05; 10. PMID: 31481934    Free PMC article.
Abul K Abbas.
Trans Am Clin Climatol Assoc, 2019 Sep 14; 130. PMID: 31516161    Free PMC article.
Discovery Strategies to Maximize the Clinical Potential of T-Cell Engaging Antibodies for the Treatment of Solid Tumors.
Vladimir Voynov, Paul J Adam, Andrew E Nixon, Justin M Scheer.
Antibodies (Basel), 2020 Nov 22; 9(4). PMID: 33217946    Free PMC article.
Comprehensive Evaluation of Immune-Checkpoint DNA Cancer Vaccines in a Rat Cholangiocarcinoma Model.
Yi-Ru Pan, Chiao-En Wu, +4 authors, Chun-Nan Yeh.
Vaccines (Basel), 2020 Dec 02; 8(4). PMID: 33255375    Free PMC article.
Overcoming Immune Evasion in Melanoma.
Kevinn Eddy, Suzie Chen.
Int J Mol Sci, 2020 Dec 02; 21(23). PMID: 33256089    Free PMC article.
Treatment Strategies and Metabolic Pathway Regulation in Urothelial Cell Carcinoma: A Comprehensive Review.
Huang-Yu Yang, Chao-Yi Wu, Jia-Jin Chen, Tao-Han Lee.
Int J Mol Sci, 2020 Dec 02; 21(23). PMID: 33256165    Free PMC article.
Fifty Years of Witnessing Biomedical Science Developments.
Manica Negahdaripour.
Iran J Med Sci, 2020 Dec 08; 45(6). PMID: 33281257    Free PMC article.
Radiation and immunotherapy: emerging mechanisms of synergy.
William G Breen, Konstantinos Leventakos, Haidong Dong, Kenneth W Merrell.
J Thorac Dis, 2020 Dec 08; 12(11). PMID: 33282406    Free PMC article.
Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy.
Yuka Igarashi, Tetsuro Sasada.
J Immunol Res, 2020 Dec 08; 2020. PMID: 33282961    Free PMC article.
Activating the Antitumor Immune Response in Non-Hodgkin Lymphoma Using Immune Checkpoint Inhibitors.
Maansi Joshi, Stephen M Ansell.
J Immunol Res, 2020 Dec 10; 2020. PMID: 33294467    Free PMC article.
Non-invasive biomarkers for monitoring the immunotherapeutic response to cancer.
Sabah Nisar, Ajaz A Bhat, +8 authors, Mohammad Haris.
J Transl Med, 2020 Dec 11; 18(1). PMID: 33298096    Free PMC article.
The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy.
Qiyao Yang, Ningning Guo, +3 authors, Min Han.
Acta Pharm Sin B, 2020 Dec 12; 10(11). PMID: 33304783    Free PMC article.
Immune checkpoint inhibitor-associated myopathy: a clinicoseropathologically distinct myopathy.
Shahar Shelly, James D Triplett, +4 authors, Teerin Liewluck.
Brain Commun, 2020 Dec 12; 2(2). PMID: 33305263    Free PMC article.
TGFβ biology in cancer progression and immunotherapy.
Rik Derynck, Shannon J Turley, Rosemary J Akhurst.
Nat Rev Clin Oncol, 2020 Jul 28; 18(1). PMID: 32710082
Intravenous injection of the oncolytic virus M1 awakens antitumor T cells and overcomes resistance to checkpoint blockade.
Yang Liu, Jing Cai, +10 authors, Jiankai Liang.
Cell Death Dis, 2020 Dec 15; 11(12). PMID: 33311488    Free PMC article.
From the T-cell receptor to cancer therapy: an interview with Tak W. Mak.
Tak W Mak.
Cell Death Differ, 2020 Dec 19; 28(1). PMID: 33335286    Free PMC article.
Association of cytotoxic T lymphocyte-associated protein 4 gene -1772T/C polymorphism with gastric cancer risk: A prisma-compliant meta-analysis.
Chenyi Zhuo, Tingzhuang Yi, +6 authors, Qianli Tang.
Medicine (Baltimore), 2020 Dec 18; 99(50). PMID: 33327303    Free PMC article.
Systematic Review.
Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells.
Silke Eisinger, Dhifaf Sarhan, +17 authors, Mikael C I Karlsson.
Proc Natl Acad Sci U S A, 2020 Nov 25; 117(50). PMID: 33229588    Free PMC article.
Cancer Immunotherapy and Application of Nanoparticles in Cancers Immunotherapy as the Delivery of Immunotherapeutic Agents and as the Immunomodulators.
Tilahun Ayane Debele, Cheng-Fa Yeh, Wen-Pin Su.
Cancers (Basel), 2020 Dec 19; 12(12). PMID: 33333816    Free PMC article.
Activation of T helper cells in sentinel node predicts poor prognosis in oral squamous cell carcinoma.
Åsa Kågedal, Eric Hjalmarsson, +7 authors, Lars Olaf Cardell.
Sci Rep, 2020 Dec 20; 10(1). PMID: 33339891    Free PMC article.
Central Nervous System Demyelination Associated With Immune Checkpoint Inhibitors: Review of the Literature.
Marcos C B Oliveira, Marcelo H de Brito, Mateus M Simabukuro.
Front Neurol, 2020 Dec 29; 11. PMID: 33362680    Free PMC article.
Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy.
Richard Lee Barrett, Ellen Puré.
Elife, 2020 Dec 29; 9. PMID: 33370234    Free PMC article.
Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule.
Alexey Berezhnoy, Bradley J Sumrow, +16 authors, Paul A Moore.
Cell Rep Med, 2020 Dec 31; 1(9). PMID: 33377134    Free PMC article.
Running to Stand Still: Naive CD8+ T Cells Actively Maintain a Program of Quiescence.
Taylah J Bennett, Vibha A V Udupa, Stephen J Turner.
Int J Mol Sci, 2020 Dec 30; 21(24). PMID: 33371448    Free PMC article.
Clinical Importance of CD200 Expression in Colorectal Liver Metastasis.
Yasuko Matsuo, Masayuki Sho, +5 authors, Yosuke Iwasa.
Ann Surg Oncol, 2021 Jan 05; 28(9). PMID: 33393050
Checkpoint inhibitor immunotherapy in kidney cancer.
Wenxin Xu, Michael B Atkins, David F McDermott.
Nat Rev Urol, 2020 Feb 06; 17(3). PMID: 32020040
The immunology of renal cell carcinoma.
C Marcela Díaz-Montero, Brian I Rini, James H Finke.
Nat Rev Nephrol, 2020 Aug 01; 16(12). PMID: 32733094
Targeting TGFβ signal transduction for cancer therapy.
Sijia Liu, Jiang Ren, Peter Ten Dijke.
Signal Transduct Target Ther, 2021 Jan 09; 6(1). PMID: 33414388    Free PMC article.
T cell antigen discovery via signaling and antigen-presenting bifunctional receptors.
Alok V Joglekar, Michael T Leonard, +9 authors, David Baltimore.
Nat Methods, 2019 Feb 01; 16(2). PMID: 30700902    Free PMC article.
Highly Cited.
Harnessing neoantigen specific CD4 T cells for cancer immunotherapy.
Spencer E Brightman, Martin S Naradikian, Aaron M Miller, Stephen P Schoenberger.
J Leukoc Biol, 2020 Mar 15; 107(4). PMID: 32170883    Free PMC article.
Emerging Therapies in Pheochromocytoma and Paraganglioma: Immune Checkpoint Inhibitors in the Starting Blocks.
Giuseppe Fanciulli, Sergio Di Molfetta, +7 authors, Nike Group.
J Clin Med, 2021 Jan 02; 10(1). PMID: 33383673    Free PMC article.
A systematic review and network meta-analysis of single nucleotide polymorphisms associated with pancreatic cancer risk.
Zhuo-Miao Ye, Li-Juan Li, +5 authors, You-Ming Tang.
Aging (Albany NY), 2020 Nov 24; 12(24). PMID: 33226370    Free PMC article.
Systematic Review.
Development of an immune-related gene pairs index for the prognosis analysis of metastatic melanoma.
Rong-Zhi Huang, Min Mao, +6 authors, Xu Li.
Sci Rep, 2021 Jan 15; 11(1). PMID: 33441929    Free PMC article.
TLRs as a Promise Target Along With Immune Checkpoint Against Gastric Cancer.
Lin Cui, Xiuqing Wang, Dekai Zhang.
Front Cell Dev Biol, 2021 Jan 21; 8. PMID: 33469538    Free PMC article.
The Search for an Interesting Partner to Combine with PD-L1 Blockade in Mesothelioma: Focus on TIM-3 and LAG-3.
Elly Marcq, Jonas R M Van Audenaerde, +5 authors, Evelien L J Smits.
Cancers (Basel), 2021 Jan 21; 13(2). PMID: 33466653    Free PMC article.
Rethinking immune checkpoint blockade: 'Beyond the T cell'.
Xiuting Liu, Graham D Hogg, David G DeNardo.
J Immunother Cancer, 2021 Jan 21; 9(1). PMID: 33468555    Free PMC article.
Next-Generation Immunotherapies to Improve Anticancer Immunity.
Yaoyao Shi, Katarzyna Tomczak, +3 authors, Cara Haymaker.
Front Pharmacol, 2021 Jan 29; 11. PMID: 33505304    Free PMC article.
The Beneficial Role of Sunitinib in Tumor Immune Surveillance by Regulating Tumor PD-L1.
Hui Li, Xinwei Kuang, +16 authors, Xiang Chen.
Adv Sci (Weinh), 2021 Jan 30; 8(2). PMID: 33510997    Free PMC article.
Understanding and Targeting Human Cancer Regulatory T Cells to Improve Therapy.
H Ryan Kolb, Nicholas Borcherding, Weizhou Zhang.
Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523451
Immune Checkpoint Molecules-Inherited Variations as Markers for Cancer Risk.
Marta Wagner, Monika Jasek, Lidia Karabon.
Front Immunol, 2021 Feb 02; 11. PMID: 33519815    Free PMC article.
Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance.
Fang Wei, Dan Wang, +10 authors, Zhaoyang Zeng.
Cell Mol Life Sci, 2020 Jul 13; 78(1). PMID: 32654036
Improving the Efficacy of Liver Cancer Immunotherapy: The Power of Combined Preclinical and Clinical Studies.
Gen-Sheng Feng, Kaisa L Hanley, Yan Liang, Xiaoxue Lin.
Hepatology, 2020 Jul 28; 73 Suppl 1. PMID: 32715491    Free PMC article.
Mesenchymal traits at the convergence of tumor-intrinsic and -extrinsic mechanisms of resistance to immune checkpoint blockers.
Paola Trono, Antonella Sistigu, +2 authors, Paola Nisticò.
Emerg Top Life Sci, 2017 Dec 12; 1(5). PMID: 33525801    Free PMC article.
Preclinical Models of Pancreatic Ductal Adenocarcinoma and Their Utility in Immunotherapy Studies.
Thao N D Pham, Mario A Shields, +6 authors, Hidayatullah G Munshi.
Cancers (Basel), 2021 Jan 29; 13(3). PMID: 33503832    Free PMC article.
PI3Kδ inhibition modulates regulatory and effector T-cell differentiation and function in chronic lymphocytic leukemia.
Bola S Hanna, Philipp M Roessner, +6 authors, Martina Seiffert.
Leukemia, 2018 Dec 24; 33(6). PMID: 30573773
Clinical and pathologic features associated with PD-L1 (SP142) expression in stromal tumor-infiltrating immune cells of triple-negative breast carcinoma.
Raza Syed Hoda, Edi Brogi, +10 authors, Hannah Yong Wen.
Mod Pathol, 2020 Jul 03; 33(11). PMID: 32612248    Free PMC article.

;. PMID: 33563927
The science and medicine of human immunology.
Bali Pulendran, Mark M Davis.
Science, 2020 Sep 26; 369(6511). PMID: 32973003    Free PMC article.
Combinations using checkpoint blockade to overcome resistance.
Stefania Morganti, Giuseppe Curigliano.
Ecancermedicalscience, 2021 Feb 13; 14. PMID: 33574893    Free PMC article.
Lysophosphatidic Acid Is an Inflammatory Lipid Exploited by Cancers for Immune Evasion via Mechanisms Similar and Distinct From CTLA-4 and PD-1.
Divij Mathew, Raul M Torres.
Front Immunol, 2021 Feb 16; 11. PMID: 33584637    Free PMC article.
Designing and Immunomodulating Multiresponsive Nanomaterial for Cancer Theranostics.
Amreen Khan, Faith Dias, +2 authors, Rohit Srivastava.
Front Chem, 2021 Feb 16; 8. PMID: 33585406    Free PMC article.
Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling.
Juanjuan Yuan, Ting Cai, +14 authors, Wei Yang.
Protein Cell, 2021 Feb 20; 12(4). PMID: 33606190    Free PMC article.
A T cell repertoire timestamp is at the core of responsiveness to CTLA-4 blockade.
Hagit Philip, Tom Snir, +3 authors, Sol Efroni.
iScience, 2021 Feb 20; 24(2). PMID: 33604527    Free PMC article.
Potential therapeutic targets in the tumor microenvironment of hepatocellular carcinoma: reversing the protumor effect of tumor-associated macrophages.
Jingyi Zhou, Weiyu Wang, Qi Li.
J Exp Clin Cancer Res, 2021 Feb 19; 40(1). PMID: 33596985    Free PMC article.
An Immune Cell Signature Is Associated With Disease-Free Survival and Adjuvant Chemosensitivity of Patients With Resectable Gastric Cancer.
Hongfei Yan, Yang Chen, +5 authors, Xiujuan Qu.
Front Immunol, 2021 Feb 23; 11. PMID: 33613554    Free PMC article.
Antigen folding improves loading efficiency and antitumor efficacy of PC7A nanoparticle vaccine.
Jonathan Wilhelm, Manuel Quiñones-Pérez, +3 authors, Jinming Gao.
J Control Release, 2020 Dec 11; 329. PMID: 33301836    Free PMC article.
Interferon γ and Its Important Roles in Promoting and Inhibiting Spontaneous and Therapeutic Cancer Immunity.
Elise Alspach, Danielle M Lussier, Robert D Schreiber.
Cold Spring Harb Perspect Biol, 2018 Apr 18; 11(3). PMID: 29661791    Free PMC article.
Highly Cited. Review.
Immune checkpoint inhibitors: a narrative review of considerations for the anaesthesiologist.
Alexandra L Lewis, Jamie Chaft, Monica Girotra, Gregory W Fischer.
Br J Anaesth, 2020 Feb 03; 124(3). PMID: 32007241    Free PMC article.
Immune checkpoint inhibitor-associated myocarditis: manifestations and mechanisms.
Javid Moslehi, Andrew H Lichtman, +2 authors, Richard N Kitsis.
J Clin Invest, 2021 Mar 02; 131(5). PMID: 33645548    Free PMC article.
Correlations Between Tumor Mutation Burden and Immunocyte Infiltration and Their Prognostic Value in Colon Cancer.
Zhangjian Zhou, Xin Xie, +7 authors, Hao Zhang.
Front Genet, 2021 Mar 06; 12. PMID: 33664769    Free PMC article.
Nivolumab-induced hypophysitis leading to hypopituitarism and secondary empty sella syndrome in a patient with non-small cell lung cancer.
Jeremy Chang, Jeffrey Tran, Dina Kamel, Arnab Basu.
BMJ Case Rep, 2019 Mar 10; 12(3). PMID: 30850565    Free PMC article.
Novel oxidative stress-related prognostic biomarkers for melanoma associated with tumor metastasis.
Xianpei Wu, Jinmin Zhao.
Medicine (Baltimore), 2021 Mar 06; 100(8). PMID: 33663112    Free PMC article.
Immune Deregulation in Sepsis and Septic Shock: Reversing Immune Paralysis by Targeting PD-1/PD-L1 Pathway.
Yuki Nakamori, Eun Jeong Park, Motomu Shimaoka.
Front Immunol, 2021 Mar 09; 11. PMID: 33679715    Free PMC article.
Generating tumor-selective conditionally active biologic anti-CTLA4 antibodies via protein-associated chemical switches.
Hwai Wen Chang, Gerhard Frey, +4 authors, Jay M Short.
Proc Natl Acad Sci U S A, 2021 Feb 26; 118(9). PMID: 33627407    Free PMC article.
A Review of Monoclonal Antibody-Based Treatments in Non-small Cell Lung Cancer.
Yunes Panahi, Amir Hossein Mohammadzadeh, +3 authors, Amirhossein Sahebkar.
Adv Exp Med Biol, 2021 Mar 17; 1286. PMID: 33725344
Prognostic Value of Deep Learning-Mediated Treatment Monitoring in Lung Cancer Patients Receiving Immunotherapy.
Stefano Trebeschi, Zuhir Bodalal, +12 authors, Regina G H Beets-Tan.
Front Oncol, 2021 Mar 20; 11. PMID: 33738253    Free PMC article.
TIM-3 and TIGIT are possible immune checkpoint targets in patients with bladder cancer.
Kyrollis Attalla, Adam M Farkas, +4 authors, John P Sfakianos.
Urol Oncol, 2020 Jul 16;. PMID: 32665122    Free PMC article.
The Role of Immune Checkpoint Molecules for Relapse After Allogeneic Hematopoietic Cell Transplantation.
Natalie Köhler, Dietrich Alexander Ruess, Rebecca Kesselring, Robert Zeiser.
Front Immunol, 2021 Mar 23; 12. PMID: 33746972    Free PMC article.
Harnessing Tumor Necrosis Factor Alpha to Achieve Effective Cancer Immunotherapy.
María Florencia Mercogliano, Sofía Bruni, +2 authors, Roxana Schillaci.
Cancers (Basel), 2021 Feb 06; 13(3). PMID: 33540543    Free PMC article.
Systemic adverse effects and toxicities associated with immunotherapy: A review.
Asim Kichloo, Michael Albosta, +7 authors, Manidhar Lekkala.
World J Clin Oncol, 2021 Mar 27; 12(3). PMID: 33767971    Free PMC article.
Pyroptosis: mechanisms and diseases.
Pian Yu, Xu Zhang, +3 authors, Xiang Chen.
Signal Transduct Target Ther, 2021 Mar 30; 6(1). PMID: 33776057    Free PMC article.
A view on drug resistance in cancer.
Neil Vasan, José Baselga, David M Hyman.
Nature, 2019 Nov 15; 575(7782). PMID: 31723286    Free PMC article.
Highly Cited. Review.
Integrative Analysis of the Expression of SIGLEC Family Members in Lung Adenocarcinoma via Data Mining.
Haiyan Zhang, Yongfei Xie, +6 authors, Qing Yuan.
Front Oncol, 2021 Apr 03; 11. PMID: 33796453    Free PMC article.
Targeting the Tumor Microenvironment for Improving Therapeutic Effectiveness in Cancer Immunotherapy: Focusing on Immune Checkpoint Inhibitors and Combination Therapies.
I-Tsu Chyuan, Ching-Liang Chu, Ping-Ning Hsu.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33801815    Free PMC article.
Emerging Trends for Radio-Immunotherapy in Rectal Cancer.
Claudia Corrò, Valérie Dutoit, Thibaud Koessler.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33803620    Free PMC article.
Biological Heterogeneity of Chondrosarcoma: From (Epi) Genetics through Stemness and Deregulated Signaling to Immunophenotype.
Agnieszka Zając, Sylwia K Król, Piotr Rutkowski, Anna M Czarnecka.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33804155    Free PMC article.
Immune Checkpoints Pathways in Head and Neck Squamous Cell Carcinoma.
Florencia Veigas, Yamil D Mahmoud, +3 authors, María Romina Girotti.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33804419    Free PMC article.
Specific Patterns of Blood ILCs in Metastatic Melanoma Patients and Their Modulations in Response to Immunotherapy.
Louise Rethacker, Marie Roelens, +3 authors, Anne Caignard.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33810032    Free PMC article.
Cancer immunotherapies revisited: state of the art of conventional treatments and next-generation nanomedicines.
Coral García-Fernández, Anna Saz, Cristina Fornaguera, Salvador Borrós.
Cancer Gene Ther, 2021 Apr 11; 28(9). PMID: 33837365
Promising potential of [177Lu]Lu-DOTA-folate to enhance tumor response to immunotherapy-a preclinical study using a syngeneic breast cancer model.
Patrycja Guzik, Klaudia Siwowska, +4 authors, Cristina Müller.
Eur J Nucl Med Mol Imaging, 2020 Oct 21; 48(4). PMID: 33078260    Free PMC article.
Engaging the Innate and Adaptive Antitumor Immune Response in Lymphoma.
Clifford M Csizmar, Stephen M Ansell.
Int J Mol Sci, 2021 Apr 04; 22(7). PMID: 33804869    Free PMC article.
Mechanisms of Immune Evasion in Acute Lymphoblastic Leukemia.
Agata Pastorczak, Krzysztof Domka, +2 authors, Malgorzata Firczuk.
Cancers (Basel), 2021 Apr 04; 13(7). PMID: 33810515    Free PMC article.
Pancreatic Cancer: An Emphasis on Current Perspectives in Immunotherapy.
Krishna Patel, Sohail Siraj, +3 authors, Riyaz Basha.
Crit Rev Oncog, 2019 Nov 05; 24(2). PMID: 31679206    Free PMC article.
Identification of Tumor Antigens in the HLA Peptidome of Patient-derived Xenograft Tumors in Mouse.
Nataly Mancette Rijensky, Netta R Blondheim Shraga, +11 authors, Arie Admon.
Mol Cell Proteomics, 2020 May 27; 19(8). PMID: 32451349    Free PMC article.
"Present and future of immunotherapy in Neuroendocrine Tumors".
Manuela Albertelli, Andrea Dotto, +6 authors, Diego Ferone.
Rev Endocr Metab Disord, 2021 Apr 15; 22(3). PMID: 33851319    Free PMC article.
Clinical Update on Checkpoint Inhibitor Therapy for Conjunctival and Eyelid Melanoma.
Jonathan E Lu, Jessica R Chang, +2 authors, Sandy Zhang-Nunes.
Int Ophthalmol Clin, 2020 Mar 25; 60(2). PMID: 32205655    Free PMC article.
Common germline variants of the human APOE gene modulate melanoma progression and survival.
Benjamin N Ostendorf, Jana Bilanovic, +4 authors, Sohail F Tavazoie.
Nat Med, 2020 May 27; 26(7). PMID: 32451497    Free PMC article.
Metabolic barriers to cancer immunotherapy.
Kristin DePeaux, Greg M Delgoffe.
Nat Rev Immunol, 2021 May 01; 21(12). PMID: 33927375    Free PMC article.
Epigenomics and immunotherapeutic advances in pediatric brain tumors.
Malak Abedalthagafi, Nahla Mobark, May Al-Rashed, Musa AlHarbi.
NPJ Precis Oncol, 2021 May 02; 5(1). PMID: 33931704    Free PMC article.
Immunotherapy for Prostate Cancer.
Nicholas J Venturini, Charles G Drake.
Cold Spring Harb Perspect Med, 2018 Sep 12; 9(5). PMID: 30201787    Free PMC article.
The 2018 Nobel Prize in Medicine for breakthroughs in targeting immune checkpoint inhibitors: a brief perspective.
Adan Rios, Georgina To'a Salazar, Ningyan Zhang, Zhiqiang An.
Antib Ther, 2019 Mar 14; 2(1). PMID: 33928220    Free PMC article.
The abscopal effect: a sense of DNA damage is in the air.
Timothy P Lippert, Roger A Greenberg.
J Clin Invest, 2021 May 04; 131(9). PMID: 33938453    Free PMC article.
Integrated Analysis Reveals Prognostic Value and Immune Correlates of CD86 Expression in Lower Grade Glioma.
Huaide Qiu, Wei Tian, +5 authors, Jianan Li.
Front Oncol, 2021 May 07; 11. PMID: 33954112    Free PMC article.
Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment.
Naixue Yang, Fansen Ji, +4 authors, Xun Lan.
NPJ Precis Oncol, 2021 May 09; 5(1). PMID: 33963274    Free PMC article.
Biological bases of cancer immunotherapy.
Maryanne M Gonzales Carazas, Joseph A Pinto, Fanny L Casado.
Expert Rev Mol Med, 2021 Mar 26; 23. PMID: 33762030    Free PMC article.
LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy.
Naveen Sharma, Oluwatomisin T Atolagbe, Zhongqi Ge, James P Allison.
J Exp Med, 2021 May 12; 218(7). PMID: 33974041    Free PMC article.
Emerging therapeutic targets for sepsis.
Elizabeth W Tindal, Brandon E Armstead, +2 authors, Alfred Ayala.
Expert Opin Ther Targets, 2021 Mar 02; 25(3). PMID: 33641552    Free PMC article.
Role of Immune Checkpoint Inhibitors in Cervical Cancer: From Preclinical to Clinical Data.
Simona Duranti, Antonella Pietragalla, +4 authors, Domenica Lorusso.
Cancers (Basel), 2021 May 01; 13(9). PMID: 33925884    Free PMC article.
Terminal Epitope-Dependent Branch Preference of Siglecs Toward N-Glycans.
Shuaishuai Wang, Congcong Chen, +3 authors, Lei Li.
Front Mol Biosci, 2021 May 18; 8. PMID: 33996901    Free PMC article.
Local Depletion of Immune Checkpoint Ligand CTLA4 Expressing Cells in Tumor Beds Enhances Antitumor Host Immunity.
Ryuhei Okada, Takuya Kato, +4 authors, Hisataka Kobayashi.
Adv Ther (Weinh), 2021 May 18; 4(5). PMID: 33997271    Free PMC article.
Mechanisms and Management of Immune Checkpoint Inhibitor-Related Cardiac Adverse Events.
Hiroshi Kadowaki, Hiroshi Akazawa, Junichi Ishida, Issei Komuro.
JMA J, 2021 May 18; 4(2). PMID: 33997442    Free PMC article.
Identification of CTLA-4-Positive Cells in the Human Tonsil.
Markus Tiemann, Dmitri Atiakshin, Vera Samoilova, Igor Buchwalow.
Cells, 2021 May 01; 10(5). PMID: 33925389    Free PMC article.
Targeting Epigenetics to Cure HIV-1: Lessons From (and for) Cancer Treatment.
J Peter Svensson.
Front Cell Infect Microbiol, 2021 May 25; 11. PMID: 34026665    Free PMC article.
CTLA-4 +49 A/G Polymorphism and the Risk of Lung Cancer: a Meta-analysis.
Zhengliang Wei, Shaoqin Zhang, Jian Hu.
Zhongguo Fei Ai Za Zhi, 2021 Apr 06; 24(3). PMID: 33819967    Free PMC article.
Systematic Review.
Nanobodies in cancer.
Elisha R Verhaar, Andrew W Woodham, Hidde L Ploegh.
Semin Immunol, 2020 Dec 05; 52. PMID: 33272897    Free PMC article.
Modulating T Follicular Cells In Vivo Enhances Antigen-Specific Humoral Immunity.
Jose D Pagan, Hera Vlamakis, +2 authors, Robert M Anthony.
J Immunol, 2021 May 21; 206(11). PMID: 34011521    Free PMC article.
Immunotherapy for Glioblastoma: Current Progress and Challenges.
Miranda W Yu, Daniela F Quail.
Front Immunol, 2021 Jun 01; 12. PMID: 34054867    Free PMC article.
The landscape of tumors-infiltrate immune cells in papillary thyroid carcinoma and its prognostic value.
Yanyi Huang, Tao Yi, +3 authors, Yunxia Lv.
PeerJ, 2021 Jun 01; 9. PMID: 34055497    Free PMC article.
Cripto-1 as a Potential Target of Cancer Stem Cells for Immunotherapy.
Hiroko Ishii, Said M Afify, +2 authors, Masaharu Seno.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34065315    Free PMC article.
Acute Myeloid Leukemia: Is It T Time?
Meriem Ben Khoud, Tiziano Ingegnere, +2 authors, Carine Brinster.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34069204    Free PMC article.
Immune Checkpoint Inhibition for Triple-Negative Breast Cancer: Current Landscape and Future Perspectives.
Huimei Yi, Ying Li, +3 authors, Xiyun Deng.
Front Oncol, 2021 Jun 08; 11. PMID: 34094935    Free PMC article.
CRISPR/Cas9 Gene-Editing in Cancer Immunotherapy: Promoting the Present Revolution in Cancer Therapy and Exploring More.
Xuejin Ou, Qizhi Ma, +2 authors, Zhiyao He.
Front Cell Dev Biol, 2021 Jun 08; 9. PMID: 34095145    Free PMC article.
Reprogramming the anti-tumor immune response via CRISPR genetic and epigenetic editing.
Eric Alves, Shahama Taifour, +4 authors, Pilar Blancafort.
Mol Ther Methods Clin Dev, 2021 Jun 08; 21. PMID: 34095343    Free PMC article.
Durvalumab Plus Tremelimumab in Solid Tumors: A Systematic Review.
Caterina Arru, Maria Rosaria De Miglio, +4 authors, Panagiotis Paliogiannis.
Adv Ther, 2021 Jun 10; 38(7). PMID: 34105088    Free PMC article.
Systematic Review.
Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review.
Kyoko Oura, Asahiro Morishita, Joji Tani, Tsutomu Masaki.
Int J Mol Sci, 2021 Jun 03; 22(11). PMID: 34071550    Free PMC article.
Mechanism-based treatment of cancer with immune checkpoint inhibitor therapies.
Yara Abdou, Manu Pandey, +3 authors, Marc S Ernstoff.
Br J Clin Pharmacol, 2020 Apr 24; 86(9). PMID: 32323342    Free PMC article.
The Immunology of Hormone Receptor Positive Breast Cancer.
Jonathan Goldberg, Ricardo G Pastorello, +9 authors, Jennifer L Guerriero.
Front Immunol, 2021 Jun 18; 12. PMID: 34135901    Free PMC article.
Cancer-associated fibroblasts: key determinants of tumor immunity and immunotherapy.
Richard Barrett, Ellen Puré.
Curr Opin Immunol, 2020 May 14; 64. PMID: 32402828    Free PMC article.
Genetic Alterations in Gliomas Remodel the Tumor Immune Microenvironment and Impact Immune-Mediated Therapies.
Maria B Garcia-Fabiani, Santiago Haase, +15 authors, Maria G Castro.
Front Oncol, 2021 Jun 26; 11. PMID: 34168976    Free PMC article.
Targeting the extracellular matrix for immunomodulation: applications in drug delivery and cell therapies.
Samira Aghlara-Fotovat, Amanda Nash, +2 authors, Omid Veiseh.
Drug Deliv Transl Res, 2021 Jun 28; 11(6). PMID: 34176099
PTPN3 is a potential target for a new cancer immunotherapy that has a dual effect of T cell activation and direct cancer inhibition in lung neuroendocrine tumor.
Satoko Koga, Hideya Onishi, +11 authors, Masafumi Nakamura.
Transl Oncol, 2021 Jun 17; 14(9). PMID: 34134073    Free PMC article.
Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers.
Angela Tata, Garvin Dodard, +5 authors, Laurent Brossay.
Oncoimmunology, 2021 Jul 01; 10(1). PMID: 34188973    Free PMC article.
Modelling the interplay between the CD4[Formula: see text]/CD8[Formula: see text] T-cell ratio and the expression of MHC-I in tumours.
Christian John Hurry, Alexander Mozeika, Alessia Annibale.
J Math Biol, 2021 Jun 19; 83(1). PMID: 34143314    Free PMC article.
Metabolic Reprogramming of Colorectal Cancer Cells and the Microenvironment: Implication for Therapy.
Miljana Nenkov, Yunxia Ma, Nikolaus Gaßler, Yuan Chen.
Int J Mol Sci, 2021 Jul 03; 22(12). PMID: 34200820    Free PMC article.
The Evolution of Cancer Immunotherapy.
Meshaal Khan, Ajay V Maker, Shikha Jain.
Vaccines (Basel), 2021 Jul 03; 9(6). PMID: 34200997    Free PMC article.
Virtual Evolution of HVEM Segment for Checkpoint Inhibitor Discovery.
Mingjia Yu, Huimin Zhao, +2 authors, Song Xue.
Int J Mol Sci, 2021 Jul 03; 22(12). PMID: 34205742    Free PMC article.
Applications and analytical tools of cell communication based on ligand-receptor interactions at single cell level.
Fen Ma, Siwei Zhang, +3 authors, Fengmin Zhang.
Cell Biosci, 2021 Jul 05; 11(1). PMID: 34217372    Free PMC article.
MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It.
Elena Shklovskaya, Helen Rizos.
Int J Mol Sci, 2021 Jul 03; 22(13). PMID: 34201655    Free PMC article.
The Natural History of T Cell Metabolism.
Michel Y Braun.
Int J Mol Sci, 2021 Jul 03; 22(13). PMID: 34202553    Free PMC article.
The mechanisms of action of Plasmodium infection against cancer.
Xiaoping Chen, Li Qin, Wen Hu, Dickson Adah.
Cell Commun Signal, 2021 Jul 11; 19(1). PMID: 34243757    Free PMC article.
FOXA1 overexpression suppresses interferon signaling and immune response in cancer.
Yundong He, Liguo Wang, +26 authors, Haojie Huang.
J Clin Invest, 2021 Jun 09; 131(14). PMID: 34101624    Free PMC article.
Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity.
Itziar Ibarlucea-Benitez, Polina Weitzenfeld, Patrick Smith, Jeffrey V Ravetch.
Proc Natl Acad Sci U S A, 2021 Jun 23; 118(26). PMID: 34155121    Free PMC article.
The KrasG12D;Trp53fl/fl murine model of undifferentiated pleomorphic sarcoma is macrophage dense, lymphocyte poor, and resistant to immune checkpoint blockade.
Karys M Hildebrand, Arvind K Singla, +9 authors, Michael J Monument.
PLoS One, 2021 Jul 10; 16(7). PMID: 34242269    Free PMC article.
The knowns & unknowns of pulmonary toxicity following immune checkpoint inhibitor therapies: a narrative review.
Alistair R Miller, Renee Manser.
Transl Lung Cancer Res, 2021 Jul 24; 10(6). PMID: 34295675    Free PMC article.
Immunotherapy and Vaccination in Surgically Resectable Non-Small Cell Lung Cancer (NSCLC).
Li-Chung Chiu, Shu-Min Lin, +3 authors, Ping-Chih Hsu.
Vaccines (Basel), 2021 Jul 03; 9(7). PMID: 34201650    Free PMC article.
Senescence and Aging: Does It Impact Cancer Immunotherapies?
Damien Maggiorani, Christian Beauséjour.
Cells, 2021 Jul 03; 10(7). PMID: 34206425    Free PMC article.
Immune-related toxicities of checkpoint inhibitors: mechanisms and mitigation strategies.
Ryan J Sullivan, Jeffrey S Weber.
Nat Rev Drug Discov, 2021 Jul 29;. PMID: 34316029
Cancer-Associated Fibroblasts: Implications for Cancer Therapy.
Ana Maia, Stefan Wiemann.
Cancers (Basel), 2021 Jul 25; 13(14). PMID: 34298736    Free PMC article.
Submicron particle docetaxel intratumoral injection in combination with anti-mCTLA-4 into 4T1-Luc orthotopic implants reduces primary tumor and metastatic pulmonary lesions.
Holly Maulhardt, Alyson Marin, Holly Hesseltine, Gere diZerega.
Med Oncol, 2021 Aug 01; 38(9). PMID: 34331595    Free PMC article.
IDO Inhibition Facilitates Antitumor Immunity of Vγ9Vδ2 T Cells in Triple-Negative Breast Cancer.
Peng Li, Ruan Wu, +8 authors, Yunfei Gao.
Front Oncol, 2021 Aug 13; 11. PMID: 34381711    Free PMC article.
Adoptive cellular therapy in solid tumor malignancies: review of the literature and challenges ahead.
Kedar Kirtane, Hany Elmariah, Christine H Chung, Daniel Abate-Daga.
J Immunother Cancer, 2021 Jul 25; 9(7). PMID: 34301811    Free PMC article.
Expression of Immune Checkpoint Receptors in Placentae With Infectious and Non-Infectious Chronic Villitis.
Maryam Shahi, Ricardo Mamber Czeresnia, +3 authors, Elizabeth Ann L Enninga.
Front Immunol, 2021 Aug 17; 12. PMID: 34394102    Free PMC article.
Immune PET Imaging.
Osigbemhe Iyalomhe, Michael D Farwell.
Radiol Clin North Am, 2021 Aug 17; 59(5). PMID: 34392924    Free PMC article.
Melanoma models for the next generation of therapies.
E Elizabeth Patton, Kristen L Mueller, +33 authors, Glenn Merlino.
Cancer Cell, 2021 Feb 06; 39(5). PMID: 33545064    Free PMC article.
sCD28, sCD80, sCTLA-4, and sBTLA Are Promising Markers in Diagnostic and Therapeutic Approaches for Aseptic Loosening and Periprosthetic Joint Infection.
Jil M Jubel, Thomas M Randau, +6 authors, Frank A Schildberg.
Front Immunol, 2021 Aug 24; 12. PMID: 34421900    Free PMC article.
Stem cell fate in cancer growth, progression and therapy resistance.
Nikki K Lytle, Alison G Barber, Tannishtha Reya.
Nat Rev Cancer, 2018 Sep 20; 18(11). PMID: 30228301    Free PMC article.
Highly Cited. Review.
The Prognostic Value of the Lymph Node in Oesophageal Adenocarcinoma; Incorporating Clinicopathological and Immunological Profiling.
Noel E Donlon, Maria Davern, +13 authors, Joanne Lysaght.
Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439160    Free PMC article.
Epigenetic Regulation of Immunotherapy Response in Triple-Negative Breast Cancer.
Pere Llinàs-Arias, Sandra Íñiguez-Muñoz, +6 authors, Diego M Marzese.
Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439290    Free PMC article.
The State of Immunotherapy in Hepatobiliary Cancers.
Farhan Z Ilyas, Joal D Beane, Timothy M Pawlik.
Cells, 2021 Aug 28; 10(8). PMID: 34440865    Free PMC article.
T-Cell Responses in Merkel Cell Carcinoma: Implications for Improved Immune Checkpoint Blockade and Other Therapeutic Options.
Laura Gehrcken, Tatjana Sauerer, Niels Schaft, Jan Dörrie.
Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445385    Free PMC article.
Germline genetic contribution to the immune landscape of cancer.
Rosalyn W Sayaman, Mohamad Saad, +23 authors, Davide Bedognetti.
Immunity, 2021 Feb 11; 54(2). PMID: 33567262    Free PMC article.
The Challenge of ICIs Resistance in Solid Tumours: Could Microbiota and Its Diversity Be Our Secret Weapon?
Michela Roberto, Catia Carconi, +4 authors, Paolo Marchetti.
Front Immunol, 2021 Sep 08; 12. PMID: 34489956    Free PMC article.
Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune Responses.
Allan Scarpitta, Ulrich T Hacker, +2 authors, Sahil Adriouch.
Front Oncol, 2021 Sep 08; 11. PMID: 34490126    Free PMC article.
The Role of Oncogenes and Redox Signaling in the Regulation of PD-L1 in Cancer.
Christophe Glorieux, Xiaojun Xia, Peng Huang.
Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503236    Free PMC article.
Immunotherapeutic Strategies for Canine Lymphoma: Changing the Odds Against Non-Hodgkin Lymphoma.
Joana N R Dias, Ana S André, +3 authors, Frederico Aires-da-Silva.
Front Vet Sci, 2021 Sep 14; 8. PMID: 34513964    Free PMC article.
Advanced therapeutic modalities in hepatocellular carcinoma: Novel insights.
Bahare Shokoohian, Babak Negahdari, +7 authors, Massoud Vosough.
J Cell Mol Med, 2021 Aug 24; 25(18). PMID: 34423899    Free PMC article.
CTLA-4 Synergizes With PD1/PD-L1 in the Inhibitory Tumor Microenvironment of Intrahepatic Cholangiocarcinoma.
Xiao-Jun Guo, Jia-Cheng Lu, +17 authors, Xiao-Yong Huang.
Front Immunol, 2021 Sep 17; 12. PMID: 34526987    Free PMC article.
Moving Immune Therapy Forward Targeting TME.
Kayla F Goliwas, Jessy S Deshane, Craig A Elmets, Mohammad Athar.
Physiol Rev, 2020 Aug 14; 101(2). PMID: 32790578    Free PMC article.
Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer.
Yong-Bo Kang, Yue Cai.
World J Gastroenterol, 2021 Sep 21; 27(32). PMID: 34539138    Free PMC article.
Immune escape mechanisms and immunotherapy of urothelial bladder cancer.
Zhao Yang, Yinyan Xu, +16 authors, Changyuan Yu.
J Clin Transl Res, 2021 Sep 21; 7(4). PMID: 34541363    Free PMC article.
Development of preclinical and clinical models for immune-related adverse events following checkpoint immunotherapy: a perspective from SITC and AACR.
Nicholas L Bayless, Jeffrey A Bluestone, +8 authors, Theresa L Walunas.
J Immunother Cancer, 2021 Sep 05; 9(9). PMID: 34479924    Free PMC article.
The Status of Adjuvant and Neoadjuvant Melanoma Therapy, New Developments and Upcoming Challenges.
Henner Stege, Maximilian Haist, +5 authors, Stephan Grabbe.
Target Oncol, 2021 Sep 24; 16(5). PMID: 34554353    Free PMC article.
Prognostic and therapeutic TILs of cervical cancer-Current advances and future perspectives.
Ying Tang, Anne X J Zhang, +2 authors, Wenyi Gu.
Mol Ther Oncolytics, 2021 Sep 24; 22. PMID: 34553029    Free PMC article.
CD47-targeting antibodies as a novel therapeutic strategy in hematologic malignancies.
Jennifer Sun, Yixuan Chen, +3 authors, Abdel Kareem Azab.
Leuk Res Rep, 2021 Sep 30; 16. PMID: 34584838    Free PMC article.
Epitranscriptomic Approach: To Improve the Efficacy of ICB Therapy by Co-Targeting Intracellular Checkpoint CISH.
Sunil Kumar, Parth Sarthi, +4 authors, Yong-Soo Bae.
Cells, 2021 Sep 29; 10(9). PMID: 34571899    Free PMC article.
Inhibiting the Unconventionals: Importance of Immune Checkpoint Receptors in γδ T, MAIT, and NKT Cells.
Elisa Catafal-Tardos, Maria Virginia Baglioni, Vasileios Bekiaris.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572874    Free PMC article.
Targeting the spectrum of immune checkpoints in prostate cancer.
Laura A Sena, Samuel R Denmeade, Emmanuel S Antonarakis.
Expert Rev Clin Pharmacol, 2021 Jul 16; 14(10). PMID: 34263692    Free PMC article.
Immune checkpoints and immunotherapy in non-small cell lung cancer: Novel study progression, challenges and solutions.
Lin-Rui Ma, Jia-Xin Li, +5 authors, Pei-Yu Yan.
Oncol Lett, 2021 Oct 02; 22(5). PMID: 34594428    Free PMC article.
Metabolic Modifications, Inflammation, and Cancer Immunotherapy.
Sihao Zheng, Qibin Song, Pingfeng Zhang.
Front Oncol, 2021 Oct 12; 11. PMID: 34631531    Free PMC article.
A mouse model for the study of anti-tumor T cell responses in Kras-driven lung adenocarcinoma.
Brittany Fitzgerald, Kelli A Connolly, +7 authors, Nikhil S Joshi.
Cell Rep Methods, 2021 Oct 12; 1(5). PMID: 34632444    Free PMC article.
Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer.
Fernanda G Kugeratski, Kathleen M McAndrews, Raghu Kalluri.
Endocrinology, 2021 Jan 08; 162(3). PMID: 33411885    Free PMC article.
Cardiac Toxicity Associated with Cancer Immunotherapy and Biological Drugs.
Andrea Montisci, Maria Teresa Vietri, +3 authors, Claudio Napoli.
Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638281    Free PMC article.
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.
R K Subbarao Malireddi, Rajendra Karki, +4 authors, Thirumala-Devi Kanneganti.