Enhancement of antitumor immunity by CTLA-4 blockade

D R Leach ¹, M F Krummel , J P Allison

Affiliations

¹ Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA.

PMID: 8596936
1204 citations

Abstract

One reason for the poor immunogenicity of many tumors may be that they cannot provide signals for CD28-mediated costimulation necessary to fully activate T cells. It has recently become apparent that CTLA-4, a second counterreceptor for the B7 family of costimulatory molecules, is a negative regulator of T cell activation. Here, in vivo administration of antibodies to CTLA-4 resulted in the rejection of tumors, including preestablished tumors. Furthermore, this rejection resulted in immunity to a secondary exposure to tumor cells. These results suggest that blockade of the inhibitory effects of CTLA-4 can allow for, and potentiate, effective immune responses against tumor cells.

Other Links

Full text on Science (New York, N.Y.)

Cited By

Citedby
CTLA-4: a negative regulator of autoimmune disease. N J Karandikar, C L Vanderlugt, +2 authors, T L Walunas, S D Miller, J A Bluestone. less J Exp Med, 1996 Aug 01; 184(2). PMID: 8760834 Free PMC article. Highly Cited.
CD28: a signalling perspective. S G Ward. Biochem J, 1996 Sep 01; 318 ( Pt 2). PMID: 8809021 Free PMC article. Review.
The new vaccines: building viruses that elicit antitumor immunity. N P Restifo. Curr Opin Immunol, 1996 Oct 01; 8(5). PMID: 8902391 Free PMC article. Review.
Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses. M Otsuji, Y Kimura, +2 authors, T Aoe, Y Okamoto, T Saito. less Proc Natl Acad Sci U S A, 1996 Nov 12; 93(23). PMID: 8917554 Free PMC article.
Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model. S J Krinzman, G T De Sanctis, +10 authors, P W Finn. less J Clin Invest, 1996 Dec 15; 98(12). PMID: 8981913 Free PMC article.
Immunotherapy II: Antigens, receptors and costimulation. P F Searle, L S Young. Cancer Metastasis Rev, 1996 Sep 01; 15(3). PMID: 9034595 Review.
CD28/B7 regulation of autoimmune diabetes. K G Herold, D J Lenschow, J A Bluestone. Immunol Res, 1997 Feb 01; 16(1). PMID: 9048209 Review.
CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion. Y Wu, Y Guo, +2 authors, A Huang, P Zheng, Y Liu. less J Exp Med, 1997 Apr 07; 185(7). PMID: 9104819 Free PMC article.
Accumulation of CTLA-4 expressing T lymphocytes in the germinal centres of human lymphoid tissues. J Castan, K Tenner-Racz, +2 authors, P Racz, B Fleischer, B M Bröker. less Immunology, 1997 Feb 01; 90(2). PMID: 9135556 Free PMC article.
Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer. E D Kwon, A A Hurwitz, +5 authors, J P Allison. less Proc Natl Acad Sci U S A, 1997 Jul 22; 94(15). PMID: 9223321 Free PMC article. Highly Cited.
Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70. C R Calvo, D Amsen, A M Kruisbeek. J Exp Med, 1997 Dec 31; 186(10). PMID: 9362525 Free PMC article.
Induction of antigen-specific T cell anergy: An early event in the course of tumor progression. K Staveley-O'Carroll, E Sotomayor, +5 authors, H Levitsky. less Proc Natl Acad Sci U S A, 1998 Mar 14; 95(3). PMID: 9448305 Free PMC article. Highly Cited.
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. F Lühder, P Höglund, +2 authors, J P Allison, C Benoist, D Mathis. less J Exp Med, 1998 Mar 21; 187(3). PMID: 9449722 Free PMC article.
Human CTLA-4 is expressed in situ on T lymphocytes in germinal centers, in cutaneous graft-versus-host disease, and in Hodgkin's disease. K Vandenborre, J Delabie, +4 authors, P Vandenberghe. less Am J Pathol, 1998 Apr 18; 152(4). PMID: 9546357 Free PMC article.
B7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge. P Zheng, Y Wu, +2 authors, Y Guo, C Lee, Y Liu. less Proc Natl Acad Sci U S A, 1998 May 30; 95(11). PMID: 9600957 Free PMC article.
Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. H Lin, J C Rathmell, +3 authors, G S Gray, C B Thompson, J M Leiden, M L Alegre. less J Exp Med, 1998 Jul 07; 188(1). PMID: 9653096 Free PMC article.
B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28. F Fallarino, P E Fields, T F Gajewski. J Exp Med, 1998 Jul 07; 188(1). PMID: 9653097 Free PMC article.
CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma. A A Hurwitz, T F Yu, D R Leach, J P Allison. Proc Natl Acad Sci U S A, 1998 Aug 26; 95(17). PMID: 9707601 Free PMC article. Highly Cited.
Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells. W Chen, W Jin, S M Wahl. J Exp Med, 1998 Nov 17; 188(10). PMID: 9815262 Free PMC article.
An anti-CD19 antibody coupled to a tetanus toxin peptide induces efficient Fas ligand (FasL)-mediated cytotoxicity of a transformed human B cell line by specific CD4+ T cells. G Eberl, S Jiang, +3 authors, Z Yu, P Schneider, G Corradin, J P Mach. less Clin Exp Immunol, 1998 Nov 20; 114(2). PMID: 9822273 Free PMC article.
Developing recombinant and synthetic vaccines for the treatment of melanoma. N P Restifo, S A Rosenberg. Curr Opin Oncol, 1999 Jan 23; 11(1). PMID: 9914879 Free PMC article. Review.
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can regulate dendritic cell-induced activation and cytotoxicity of CD8(+) T cells independently of CD4(+) T cell help. K D McCoy, I F Hermans, +2 authors, J H Fraser, G Le Gros, F Ronchese. less J Exp Med, 1999 Apr 06; 189(7). PMID: 10190907 Free PMC article.
Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection. K Steiner, I Waase, +3 authors, T Rau, M Dietrich, B Fleischer, B M Bröker. less Clin Exp Immunol, 1999 Apr 08; 115(3). PMID: 10193417 Free PMC article.
Inducing autoimmune disease to treat cancer. D M Pardoll. Proc Natl Acad Sci U S A, 1999 May 13; 96(10). PMID: 10318881 Free PMC article.
Cytotoxic T-lymphocyte epitope immunodominance in the control of choroid plexus tumors in simian virus 40 large T antigen transgenic mice. T D Schell, L M Mylin, +3 authors, I Georgoff, A K Teresky, A J Levine, S S Tevethia. less J Virol, 1999 Jun 11; 73(7). PMID: 10364350 Free PMC article.
Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation. F J Barrat, F Le Deist, +4 authors, G de Saint Basile. less Proc Natl Acad Sci U S A, 1999 Jul 21; 96(15). PMID: 10411929 Free PMC article.
CTLA-4 blockade enhances the immune response induced by mycobacterial infection but does not lead to increased protection. J Kirman, K McCoy, +5 authors, G Le Gros. less Infect Immun, 1999 Jul 23; 67(8). PMID: 10417139 Free PMC article.
Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. A van Elsas, A A Hurwitz, J P Allison. J Exp Med, 1999 Aug 03; 190(3). PMID: 10430624 Free PMC article. Highly Cited.
In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance. E M Sotomayor, I Borrello, +2 authors, E Tubb, J P Allison, H I Levitsky. less Proc Natl Acad Sci U S A, 1999 Sep 29; 96(20). PMID: 10500201 Free PMC article.
Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation. K Vandenborre, S W Van Gool, +3 authors, P Vandenberghe. less Immunology, 1999 Dec 03; 98(3). PMID: 10583602 Free PMC article.
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy. E D Kwon, B A Foster, +4 authors, M B Burg. less Proc Natl Acad Sci U S A, 1999 Dec 28; 96(26). PMID: 10611340 Free PMC article.
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. S Read, V Malmström, F Powrie. J Exp Med, 2000 Jul 19; 192(2). PMID: 10899916 Free PMC article. Highly Cited.
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. T Takahashi, T Tagami, +5 authors, S Sakaguchi. less J Exp Med, 2000 Jul 19; 192(2). PMID: 10899917 Free PMC article. Highly Cited.
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells. F Luhder, C Chambers, +2 authors, J P Allison, C Benoist, D Mathis. less Proc Natl Acad Sci U S A, 2000 Oct 18; 97(22). PMID: 11035773 Free PMC article.
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+ T cells. M S Kuhns, V Epshteyn, R A Sobel, J P Allison. Proc Natl Acad Sci U S A, 2000 Oct 26; 97(23). PMID: 11050166 Free PMC article.
Challenges to the development of antigen-specific breast cancer vaccines. M J Scanlan, D Jäger. Breast Cancer Res, 2001 Mar 16; 3(2). PMID: 11250753 Free PMC article. Review.
Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. A van Elsas, R P Sutmuller, +8 authors, J P Allison. less J Exp Med, 2001 Aug 22; 194(4). PMID: 11514604 Free PMC article.
Increased expression of CTLA-4 (CD152) by T and B lymphocytes in Wegener's granulomatosis. K Steiner, F Moosig, +4 authors, B M Bröker. less Clin Exp Immunol, 2001 Oct 27; 126(1). PMID: 11678911 Free PMC article.
T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer. M Mercader, B K Bodner, +10 authors, E D Kwon. less Proc Natl Acad Sci U S A, 2001 Dec 06; 98(25). PMID: 11734652 Free PMC article. Highly Cited.
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Yoshiko Iwai, Masayoshi Ishida, +3 authors, Nagahiro Minato. less Proc Natl Acad Sci U S A, 2002 Sep 10; 99(19). PMID: 12218188 Free PMC article. Highly Cited.
Therapeutic vaccination with tumor cells that engage CD137. Karl Erik Hellstrom, Ingegerd Hellstrom. J Mol Med (Berl), 2003 Feb 26; 81(2). PMID: 12601523 Review.
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. F Stephen Hodi, Martin C Mihm, +14 authors, Glenn Dranoff. less Proc Natl Acad Sci U S A, 2003 Apr 17; 100(8). PMID: 12682289 Free PMC article. Highly Cited.
Tumor-associated antigens identified by mRNA expression profiling as tumor rejection epitopes. Marie Louise Andersen, Morten Ruhwald, +4 authors, Mogens H Claesson. less J Immune Based Ther Vaccines, 2003 Apr 24; 1(1). PMID: 12709261 Free PMC article.
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Giao Q Phan, James C Yang, +14 authors, Steven A Rosenberg. less Proc Natl Acad Sci U S A, 2003 Jun 27; 100(14). PMID: 12826605 Free PMC article. Highly Cited.
B7x: a widely expressed B7 family member that inhibits T cell activation. Xingxing Zang, P'ng Loke, +3 authors, James P Allison. less Proc Natl Acad Sci U S A, 2003 Aug 16; 100(18). PMID: 12920180 Free PMC article. Highly Cited.
Gene therapy for lung cancer. Eric B Haura, Eduardo Sotomayor, Scott J Antonia. Mol Biotechnol, 2003 Oct 04; 25(2). PMID: 14526124 Review.
T lymphocyte dependence of the antibody response to 'T lymphocyte independent type 2' antigens. A Jeurissen, J L Ceuppens, X Bossuyt. Immunology, 2003 Dec 18; 111(1). PMID: 14678191 Free PMC article. Review.
CTLA-4 and tolerance: the biochemical point of view. Shunsuke Chikuma, Jeffrey A Bluestone. Immunol Res, 2004 Jan 10; 28(3). PMID: 14713717 Review.
Overview of melanoma vaccines and promising approaches. Monica C Panelli, Ena Wang, +5 authors, Francesco M Marincola. less Curr Oncol Rep, 2004 Aug 05; 6(5). PMID: 15291987 Review.
Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection. Chloe L Thio, Timothy L Mosbruger, +6 authors, David L Thomas. less J Virol, 2004 Sep 29; 78(20). PMID: 15452244 Free PMC article.
Chronic immune activation associated with chronic helminthic and human immunodeficiency virus infections: role of hyporesponsiveness and anergy. Gadi Borkow, Zvi Bentwich. Clin Microbiol Rev, 2004 Oct 19; 17(4). PMID: 15489359 Free PMC article. Review.
Allogenic donor splenocytes pretreated with antisense peptide against B7 prolong cardiac allograft survival. J Chen, Q He, +4 authors, R Zhang, Y Chu, Y Wang, Q Liu, S Xiong. less Clin Exp Immunol, 2004 Oct 23; 138(2). PMID: 15498033 Free PMC article.
Understanding the response to immunotherapy in humans. Ena Wang, Monica C Panelli, Francesco M Marincola. Springer Semin Immunopathol, 2005 Jan 25; 27(1). PMID: 15666150 Review.
Fever therapy revisited. U Hobohm. Br J Cancer, 2005 Feb 09; 92(3). PMID: 15700041 Free PMC article. Review.
Multiple costimulatory modalities enhance CTL avidity. James W Hodge, Mala Chakraborty, +2 authors, Chie Kudo-Saito, Charlie T Garnett, Jeffrey Schlom. less J Immunol, 2005 May 10; 174(10). PMID: 15879092 Free PMC article.
A peripheral circulating compartment of natural naive CD4 Tregs. Danila Valmori, Andrea Merlo, +2 authors, Maha Ayyoub. less J Clin Invest, 2005 Jul 12; 115(7). PMID: 16007258 Free PMC article. Highly Cited.
Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies. Kenneth D Lute, Kenneth F May, +8 authors, Yang Liu. less Blood, 2005 Jul 23; 106(9). PMID: 16037385 Free PMC article.
Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. Peter Attia, Giao Q Phan, +14 authors, Steven A Rosenberg. less J Clin Oncol, 2005 Aug 10; 23(25). PMID: 16087944 Free PMC article. Highly Cited.
Immunotherapy for melanoma: the good, the bad, and the future. Christian H Poehlein, Dominik Rüttinger, +3 authors, Jun Ma, Hong-Ming Hu, Walter J Urba, Bernard A Fox. less Curr Oncol Rep, 2005 Aug 11; 7(5). PMID: 16091201 Review.
Combining radiotherapy and immunotherapy: a revived partnership. Sandra Demaria, Nina Bhardwaj, William H McBride, Silvia C Formenti. Int J Radiat Oncol Biol Phys, 2005 Oct 04; 63(3). PMID: 16199306 Free PMC article. Highly Cited. Review.
Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes. Sharad Purohit, Robert Podolsky, +6 authors, Jin-Xiong She. less J Autoimmune Dis, 2005 Nov 02; 2. PMID: 16259622 Free PMC article.
Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ajay V Maker, Giao Q Phan, +11 authors, Steven A Rosenberg. less Ann Surg Oncol, 2005 Nov 12; 12(12). PMID: 16283570 Free PMC article. Highly Cited.
Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade. Ajay V Maker, Peter Attia, Steven A Rosenberg. J Immunol, 2005 Nov 23; 175(11). PMID: 16301685 Free PMC article.
CD28-mediated costimulation impacts on the differentiation of DC vaccination-induced T cell responses. H Voigt, D Schrama, +6 authors, F Lühder. less Clin Exp Immunol, 2005 Dec 22; 143(1). PMID: 16367939 Free PMC article.
Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. Kimberly E Beck, Joseph A Blansfield, +12 authors, James C Yang. less J Clin Oncol, 2006 May 20; 24(15). PMID: 16710025 Free PMC article. Highly Cited.
Checkpoint blockade in cancer immunotherapy. Alan J Korman, Karl S Peggs, James P Allison. Adv Immunol, 2006 May 30; 90. PMID: 16730267 Free PMC article. Highly Cited. Review.
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. Sergio A Quezada, Karl S Peggs, Michael A Curran, James P Allison. J Clin Invest, 2006 Jun 17; 116(7). PMID: 16778987 Free PMC article. Highly Cited.
Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma. Ajay V Maker, James C Yang, +11 authors, Steven A Rosenberg. less J Immunother, 2006 Jun 27; 29(4). PMID: 16799341 Free PMC article.
CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent. Luca Gattinoni, Anju Ranganathan, +6 authors, Nicholas P Restifo. less Blood, 2006 Aug 03; 108(12). PMID: 16882704 Free PMC article.
Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) immunotherapy for the treatment of prostate cancer. R Houston Thompson, James P Allison, Eugene D Kwon. Urol Oncol, 2006 Sep 12; 24(5). PMID: 16962497 Free PMC article. Review.
Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. Simon Read, Rebecca Greenwald, +5 authors, Fiona Powrie. less J Immunol, 2006 Sep 20; 177(7). PMID: 16982872 Free PMC article. Highly Cited.
Autoantibodies against CD28 are associated with atopic diseases. K Neuber, B Mähnss, +2 authors, C Hübner, H Gergely, M Weichenthal. less Clin Exp Immunol, 2006 Oct 13; 146(2). PMID: 17034578 Free PMC article.
Immunosuppressive strategies that are mediated by tumor cells. Gabriel A Rabinovich, Dmitry Gabrilovich, Eduardo M Sotomayor. Annu Rev Immunol, 2006 Dec 01; 25. PMID: 17134371 Free PMC article. Highly Cited. Review.
CTLA-4 regulates allergen response by modulating GATA-3 protein level per cell. Francesca Nasta, Silvia Corinti, +3 authors, Claudio Pioli. less Immunology, 2007 Feb 23; 121(1). PMID: 17313444 Free PMC article.
Immunotherapeutic strategies for high-risk bladder cancer. Padmanee Sharma, Lloyd J Old, James P Allison. Semin Oncol, 2007 Mar 27; 34(2). PMID: 17382800 Free PMC article. Review.
Enhancing efficacy of therapeutic vaccinations by combination with other modalities. James L Gulley, Ravi A Madan, Philip M Arlen. Vaccine, 2007 Jun 19; 25 Suppl 2. PMID: 17573164 Free PMC article. Review.
CTLA-4: From conflict to clinic. Hema Bashyam. J Exp Med, 2007 Jul 17; 204(6). PMID: 17632849 Free PMC article. Review.
Activation-induced non-responsiveness (anergy) limits CD8 T cell responses to tumors. Matthew F Mescher, Flavia E Popescu, +2 authors, Michael Gerner, Chris D Hammerbeck, Julie M Curtsinger. less Semin Cancer Biol, 2007 Jul 28; 17(4). PMID: 17656106 Free PMC article. Review.
Inhibitory costimulation and anti-tumor immunity. Natalia Martin-Orozco, Chen Dong. Semin Cancer Biol, 2007 Aug 09; 17(4). PMID: 17683946 Free PMC article. Review.
Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population. Lihong Wang, Dalin Li, +3 authors, Zhenkun Fu, Heng Li, Wei Jiang, Dianjun Li. less BMC Cancer, 2007 Sep 11; 7. PMID: 17825114 Free PMC article.
Combining Vaccines with Conventional Therapies for Cancer. Philip M Arlen, Ravi A Madan, +2 authors, James W Hodge, Jeffrey Schlom, James L Gulley. less Update Cancer Ther, 2007 Oct 20; 2(1). PMID: 17948067 Free PMC article.
Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Stephanie G Downey, Jacob A Klapper, +12 authors, Steven A Rosenberg. less Clin Cancer Res, 2007 Nov 06; 13(22 Pt 1). PMID: 17982122 Free PMC article. Highly Cited.
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Xingxing Zang, R Houston Thompson, +6 authors, James P Allison. less Proc Natl Acad Sci U S A, 2007 Nov 29; 104(49). PMID: 18042703 Free PMC article. Highly Cited.
Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. James C Yang, Marybeth Hughes, +10 authors, Steven A Rosenberg. less J Immunother, 2007 Dec 01; 30(8). PMID: 18049334 Free PMC article. Highly Cited.
Regulatory T cells and tumour immunity - observations in mice and men. Awen Gallimore, Andrew Godkin. Immunology, 2007 Dec 11; 123(2). PMID: 18067556 Free PMC article. Review.
Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses. Marcio O Lasaro, Nia Tatsis, +7 authors, Hildegund C Ertl. less Nat Med, 2008 Jan 15; 14(2). PMID: 18193057 Free PMC article.
The role of TGF-beta-1 protein and TGF-beta-R-1 receptor in immune escape mechanism in bladder cancer. Amira Helmy, Olfat Ali Hammam, Tarek Ramzy El Lithy, Mohamed Mohi El Deen Wishahi. MedGenMed, 2008 Mar 04; 9(4). PMID: 18311384 Free PMC article.
Immunotherapy of malignant brain tumors. Duane A Mitchell, Peter E Fecci, John H Sampson. Immunol Rev, 2008 Mar 28; 222. PMID: 18363995 Free PMC article. Review.
Head and neck cancer immunotherapy: clinical evaluation. Michael S Leibowitz, Jayakar V Nayak, Robert L Ferris. Curr Oncol Rep, 2008 Apr 02; 10(2). PMID: 18377830 Review.
Detailed analysis of immunologic effects of the cytotoxic T lymphocyte-associated antigen 4-blocking monoclonal antibody tremelimumab in peripheral blood of patients with melanoma. Begoña Comin-Anduix, Yohan Lee, +13 authors, Antoni Ribas. less J Transl Med, 2008 May 03; 6. PMID: 18452610 Free PMC article.
Concurrent decrease in IL-10 with development of immune-related adverse events in a patient treated with anti-CTLA-4 therapy. Jingjing Sun, Jade Schiffman, +3 authors, Padmanee Sharma. less Cancer Immun, 2008 May 28; 8. PMID: 18503261 Free PMC article.
CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors. Kavita V Shah, Andy J Chien, Cassian Yee, Randall T Moon. J Invest Dermatol, 2008 Jun 20; 128(12). PMID: 18563180 Free PMC article.
CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasis. Anita L Tang, John R Teijaro, +5 authors, Donna L Farber. less J Immunol, 2008 Jul 22; 181(3). PMID: 18641318 Free PMC article.
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma. Sergio A Quezada, Karl S Peggs, +3 authors, James P Allison. less J Exp Med, 2008 Aug 30; 205(9). PMID: 18725522 Free PMC article. Highly Cited.
CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Chrysoula I Liakou, Ashish Kamat, +5 authors, Padmanee Sharma. less Proc Natl Acad Sci U S A, 2008 Sep 27; 105(39). PMID: 18818309 Free PMC article. Highly Cited.
T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy. Roch Houot, Ronald Levy. Blood, 2008 Oct 23; 113(15). PMID: 18941113 Free PMC article.
CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation. Asad Bashey, Bridget Medina, +11 authors, Edward D Ball. less Blood, 2008 Nov 01; 113(7). PMID: 18974373 Free PMC article. Highly Cited.
Therapeutic antitumor efficacy of anti-CD137 agonistic monoclonal antibody in mouse models of myeloma. Oihana Murillo, Ainhoa Arina, +11 authors, Ignacio Melero. less Clin Cancer Res, 2008 Nov 05; 14(21). PMID: 18980984 Free PMC article.
The complex role of B7 molecules in tumor immunology. Barbara Seliger, Francesco M Marincola, Soldano Ferrone, Hinrich Abken. Trends Mol Med, 2008 Nov 07; 14(12). PMID: 18986838 Free PMC article. Review.
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit. Jianda Yuan, Sacha Gnjatic, +17 authors, Jedd D Wolchok. less Proc Natl Acad Sci U S A, 2008 Dec 17; 105(51). PMID: 19074257 Free PMC article. Highly Cited.
Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues. Hong Chen, Chrysoula I Liakou, +8 authors, Padmanee Sharma. less Proc Natl Acad Sci U S A, 2009 Feb 10; 106(8). PMID: 19202079 Free PMC article.
Memory T cells need CD28 costimulation to remember. Alina C Boesteanu, Peter D Katsikis. Semin Immunol, 2009 Mar 10; 21(2). PMID: 19268606 Free PMC article. Review.
Immunotherapy for liver tumors: present status and future prospects. Pablo Matar, Laura Alaniz, +7 authors, Guillermo Mazzolini. less J Biomed Sci, 2009 Mar 11; 16. PMID: 19272130 Free PMC article. Review.
CTLA-4 co-receptor impacts on the function of Treg and CD8+ T-cell subsets. Christopher E Rudd. Eur J Immunol, 2009 Mar 14; 39(3). PMID: 19283722 Free PMC article.
Tumor vaccines for breast cancer. Karen S Anderson. Cancer Invest, 2009 Apr 10; 27(4). PMID: 19358018 Free PMC article. Review.
Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Anne S Dejean, Daniel R Beisner, +6 authors, Stephen M Hedrick. less Nat Immunol, 2009 Apr 14; 10(5). PMID: 19363483 Free PMC article. Highly Cited.
PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention. Daniel E Kaufmann, Bruce D Walker. J Immunol, 2009 May 06; 182(10). PMID: 19414738 Free PMC article. Highly Cited. Review.
An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies. D Schönfeld, G Matschiner, +8 authors, A Skerra. less Proc Natl Acad Sci U S A, 2009 May 07; 106(20). PMID: 19416843 Free PMC article.
Increased frequency and suppression by regulatory T cells in patients with acute myelogenous leukemia. Miroslaw J Szczepanski, Marta Szajnik, +6 authors, Michael Boyiadzis. less Clin Cancer Res, 2009 May 07; 15(10). PMID: 19417016 Free PMC article.
PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model. Long Zhang, Thomas F Gajewski, Justin Kline. Blood, 2009 May 07; 114(8). PMID: 19417208 Free PMC article. Highly Cited.
Costimulatory and coinhibitory receptors in anti-tumor immunity. Gregory Driessens, Justin Kline, Thomas F Gajewski. Immunol Rev, 2009 May 12; 229(1). PMID: 19426219 Free PMC article. Review.
CTLA4 blockade increases Th17 cells in patients with metastatic melanoma. Erika von Euw, Thinle Chodon, +4 authors, Antoni Ribas. less J Transl Med, 2009 May 22; 7. PMID: 19457253 Free PMC article.
Progress and challenges in the vaccine-based treatment of head and neck cancers. Aldo Venuti. J Exp Clin Cancer Res, 2009 May 29; 28. PMID: 19473517 Free PMC article. Review.
Modulating the expression of IFN regulatory factor 8 alters the protumorigenic behavior of CD11b+Gr-1+ myeloid cells. Trina J Stewart, David J Liewehr, +2 authors, Scott I Abrams. less J Immunol, 2009 Jun 23; 183(1). PMID: 19542426 Free PMC article.
Anti-CTLA4 Antibody Clinical Trials in Melanoma. Antoni Ribas. Update Cancer Ther, 2007 Sep 01; 2(3). PMID: 19543441 Free PMC article.
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. Karl S Peggs, Sergio A Quezada, +2 authors, Cynthia A Chambers, Alan J Korman, James P Allison. less J Exp Med, 2009 Jul 08; 206(8). PMID: 19581407 Free PMC article. Highly Cited.
Anti-CD40 agonist antibodies: preclinical and clinical experience. Magi Khalil, Robert H Vonderheide. Update Cancer Ther, 2007 Jun 01; 2(2). PMID: 19587842 Free PMC article.
Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: serious immune related adverse events across a spectrum of cancer subtypes. Troy Dillard, Chris G Yedinak, Joshi Alumkal, Maria Fleseriu. Pituitary, 2009 Jul 30; 13(1). PMID: 19639414 Review.
Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion. Roch Houot, Matthew J Goldstein, +8 authors, Ronald Levy. less Blood, 2009 Jul 31; 114(16). PMID: 19641184 Free PMC article.
Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists. K S Peggs, S A Quezada, J P Allison. Clin Exp Immunol, 2009 Aug 08; 157(1). PMID: 19659765 Free PMC article. Review.
Tumor vaccines expressing flt3 ligand synergize with ctla-4 blockade to reject preimplanted tumors. Michael A Curran, James P Allison. Cancer Res, 2009 Sep 10; 69(19). PMID: 19738077 Free PMC article.
Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response. Saba Alzabin, Saiju Pyarajan, +4 authors, Sansana Sawasdikosol. less Cancer Immunol Immunother, 2009 Sep 30; 59(3). PMID: 19787351 Free PMC article.
CTLA-4 +49A>G polymorphism is associated with the risk but not with the progression of colorectal cancer in Chinese. Peng Qi, Can-ping Ruan, +6 authors, Chun-fang Gao. less Int J Colorectal Dis, 2009 Sep 30; 25(1). PMID: 19787358
Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma. Antoni Ribas, Begoña Comin-Anduix, +15 authors, Jesus Gomez-Navarro. less Clin Cancer Res, 2009 Oct 01; 15(19). PMID: 19789309 Free PMC article.
Phase I study of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with relapsed and refractory B-cell non-Hodgkin lymphoma. Stephen M Ansell, Sara A Hurvitz, +10 authors, John M Timmerman. less Clin Cancer Res, 2009 Oct 08; 15(20). PMID: 19808874 Free PMC article. Highly Cited.
The role of tregs in glioma-mediated immunosuppression: potential target for intervention. William Humphries, Jun Wei, John H Sampson, Amy B Heimberger. Neurosurg Clin N Am, 2009 Dec 01; 21(1). PMID: 19944972 Free PMC article. Review.
Inhibitory RNA molecules in immunotherapy for cancer. Chih-Ping Mao, T-C Wu. Methods Mol Biol, 2010 Mar 11; 623. PMID: 20217561 Free PMC article.
Monoclonal antibodies: versatile platforms for cancer immunotherapy. Louis M Weiner, Rishi Surana, Shangzi Wang. Nat Rev Immunol, 2010 Apr 24; 10(5). PMID: 20414205 Free PMC article. Highly Cited. Review.
Local release of highly loaded antibodies from functionalized nanoporous support for cancer immunotherapy. Chenghong Lei, Pu Liu, +7 authors, Karl Erik Hellstrom. less J Am Chem Soc, 2010 May 04; 132(20). PMID: 20433206 Free PMC article.
Inhibitors of B7-CD28 costimulation in urologic malignancies. R Houston Thompson, Eugene D Kwon, James P Allison. Immunotherapy, 2009 Jan 01; 1(1). PMID: 20445772 Free PMC article.
Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial. Bradley C Carthon, Jedd D Wolchok, +8 authors, Padmanee Sharma. less Clin Cancer Res, 2010 May 13; 16(10). PMID: 20460488 Free PMC article. Highly Cited.
Antigen quality determines the efficiency of antitumor immune responses generated in the absence of regulatory T cells. A-S Bergot, A Durgeau, +3 authors, B Levacher, B M Colombo, J L Cohen, D Klatzmann. less Cancer Gene Ther, 2010 May 15; 17(9). PMID: 20467452 Free PMC article.
The biologic importance of tumor-infiltrating lymphocytes. F Stephen Hodi, Glenn Dranoff. J Cutan Pathol, 2010 May 28; 37 Suppl 1. PMID: 20482675 Free PMC article.
Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory. Rong Hu, Constance Lay-Lay Saw, Rong Yu, Ah-Ng Tony Kong. Antioxid Redox Signal, 2010 May 22; 13(11). PMID: 20486765 Free PMC article. Review.
Modulation of CTLA-4 and GITR for cancer immunotherapy. Francesca Avogadri, Jianda Yuan, +2 authors, Arvin Yang, David Schaer, Jedd D Wolchok. less Curr Top Microbiol Immunol, 2010 Jun 22; 344. PMID: 20563707 Free PMC article. Review.
CTLA-4 blockade: therapeutic potential in cancer treatments. Ahmad A Tarhini, Fatima Iqbal. Onco Targets Ther, 2010 Jul 10; 3. PMID: 20616954 Free PMC article.
Immune regulatory antibodies: are they the next advance? Jedd D Wolchok, Arvin S Yang, Jeffrey S Weber. Cancer J, 2010 Aug 10; 16(4). PMID: 20693841 Free PMC article. Review.
Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy. Margaret K Callahan, Jedd D Wolchok, James P Allison. Semin Oncol, 2010 Nov 16; 37(5). PMID: 21074063 Free PMC article. Review.
Extended dose ipilimumab with a peptide vaccine: immune correlates associated with clinical benefit in patients with resected high-risk stage IIIc/IV melanoma. Amod A Sarnaik, Bin Yu, +9 authors, Jeffrey S Weber. less Clin Cancer Res, 2010 Nov 26; 17(4). PMID: 21106722 Free PMC article.
CTLA-4 exon 1 +49 polymorphism alone and in a haplotype with -318 promoter polymorphism may confer susceptibility to chronic HBV infection in Chinese Han patients. Shaoqiong Duan, Guoyu Zhang, +11 authors, Fanfan Xing. less Mol Biol Rep, 2010 Dec 17; 38(8). PMID: 21161390
Treatment of cutaneous melanoma: current approaches and future prospects. Alain P Algazi, Christopher W Soon, Adil I Daud. Cancer Manag Res, 2010 Dec 29; 2. PMID: 21188111 Free PMC article.
Targeting NKT cells and PD-L1 pathway results in augmented anti-tumor responses in a melanoma model. Kevin Durgan, Mohamed Ali, Paul Warner, Yvette E Latchman. Cancer Immunol Immunother, 2011 Jan 18; 60(4). PMID: 21240487 Free PMC article.
Dose-dependent effect of anti-CTLA-4 on survival in sepsis. Shigeaki Inoue, Lulong Bo, +3 authors, Richard S Hotchkiss. less Shock, 2011 Mar 04; 36(1). PMID: 21368717 Free PMC article.
Expansion of regulatory T cells in aged mice following influenza infection. Yolanda Williams-Bey, Jiu Jiang, Donna M Murasko. Mech Ageing Dev, 2011 Mar 19; 132(4). PMID: 21414341 Free PMC article.
Co-inhibitory molecules: Controlling the effectors or controlling the controllers? Govindarajan Thangavelu, Christa Smolarchuk, Colin C Anderson. Self Nonself, 2011 Apr 14; 1(2). PMID: 21487510 Free PMC article.
Immunosuppressive tumor microenvironment in cervical cancer patients. Sytse J Piersma. Cancer Microenviron, 2011 Jun 01; 4(3). PMID: 21626415 Free PMC article.
Ipilimumab. Vernon K Sondak, Keiran S M Smalley, +2 authors, Ragini Kudchadkar, Seden Grippon, Peter Kirkpatrick. less Nat Rev Drug Discov, 2011 Jun 02; 10(6). PMID: 21629286
Immuno-therapy with anti-CTLA4 antibodies in tolerized and non-tolerized mouse tumor models. Jonas Persson, Ines Beyer, +4 authors, André Lieber. less PLoS One, 2011 Jul 23; 6(7). PMID: 21779410 Free PMC article.
Regulatory T cell: a protection for tumour cells. Yi Wang, Yushui Ma, +4 authors, Xizhong Shen. less J Cell Mol Med, 2011 Sep 08; 16(3). PMID: 21895966 Free PMC article. Review.
Ipilimumab: an anti-CTLA-4 antibody for metastatic melanoma. Evan J Lipson, Charles G Drake. Clin Cancer Res, 2011 Sep 09; 17(22). PMID: 21900389 Free PMC article. Highly Cited. Review.
Cell-specific aptamers as emerging therapeutics. Cindy Meyer, Ulrich Hahn, Andrea Rentmeister. J Nucleic Acids, 2011 Sep 10; 2011. PMID: 21904667 Free PMC article.
Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma. Adam J Bograd, Kei Suzuki, +4 authors, Prasad S Adusumilli. less Cancer Immunol Immunother, 2011 Sep 14; 60(11). PMID: 21913025 Free PMC article. Review.
Temporal transcriptome changes induced by MDV in Marek's disease-resistant and -susceptible inbred chickens. Ying Yu, Juan Luo, +6 authors, Jiuzhou Song. less BMC Genomics, 2011 Oct 14; 12. PMID: 21992110 Free PMC article.
Science gone translational: the OX40 agonist story. Andrew D Weinberg, Nicholas P Morris, +2 authors, Brendan D Curti. less Immunol Rev, 2011 Oct 25; 244(1). PMID: 22017441 Free PMC article. Review.
Novel cancer immunotherapy agents with survival benefit: recent successes and next steps. Padmanee Sharma, Klaus Wagner, Jedd D Wolchok, James P Allison. Nat Rev Cancer, 2011 Oct 25; 11(11). PMID: 22020206 Free PMC article. Highly Cited. Review.
Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells. Scott K Pruitt, David Boczkowski, +5 authors, Smita Nair. less Eur J Immunol, 2011 Oct 27; 41(12). PMID: 22028176 Free PMC article.
Cancer immunotherapy comes of age. Suzanne L Topalian, George J Weiner, Drew M Pardoll. J Clin Oncol, 2011 Nov 02; 29(36). PMID: 22042955 Free PMC article. Highly Cited. Review.
Blockade of cytotoxic T-lymphocyte antigen-4 as a new therapeutic approach for advanced melanoma. Xiang-Yang Wang, Daming Zuo, Devanand Sarkar, Paul B Fisher. Expert Opin Pharmacother, 2011 Nov 15; 12(17). PMID: 22077831 Free PMC article. Review.
Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy. Rebecca Waitz, Stephen B Solomon, +4 authors, James P Allison. less Cancer Res, 2011 Nov 24; 72(2). PMID: 22108823 Free PMC article.
Trypanosoma cruzi as an effective cancer antigen delivery vector. Caroline Junqueira, Luara I Santos, +9 authors, Ricardo T Gazzinelli. less Proc Natl Acad Sci U S A, 2011 Nov 25; 108(49). PMID: 22114198 Free PMC article.
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses. Lucy S K Walker, David M Sansom. Nat Rev Immunol, 2011 Nov 26; 11(12). PMID: 22116087 Highly Cited.
Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity. Sue M Liu, Andrew P R Sutherland, +7 authors, Vijay K Kuchroo. less J Immunol, 2011 Nov 30; 188(1). PMID: 22124121 Free PMC article.
Immune microenvironment in colorectal cancer: a new hallmark to change old paradigms. Luis de la Cruz-Merino, Fernando Henao Carrasco, +4 authors, Enrique Grande Pulido. less Clin Dev Immunol, 2011 Dec 14; 2011. PMID: 22162710 Free PMC article. Review.
Ipilimumab and cancer immunotherapy: a new hope for advanced stage melanoma. Matthew Mansh. Yale J Biol Med, 2011 Dec 20; 84(4). PMID: 22180676 Free PMC article. Review.
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Seng-Ryong Woo, Meghan E Turnis, +18 authors, Dario A A Vignali. less Cancer Res, 2011 Dec 22; 72(4). PMID: 22186141 Free PMC article. Highly Cited.
Tumor evasion from T cell surveillance. Katrin Töpfer, Stefanie Kempe, +5 authors, Achim Temme. less J Biomed Biotechnol, 2011 Dec 23; 2011. PMID: 22190859 Free PMC article. Review.
Cancer immunotherapy comes of age. Ira Mellman, George Coukos, Glenn Dranoff. Nature, 2011 Dec 24; 480(7378). PMID: 22193102 Free PMC article. Highly Cited. Review.
Use of anti-cancer drugs, mitocans, to enhance the immune responses against tumors. T Hahn, M J Polanczyk, +3 authors, S J Ralph. less Curr Pharm Biotechnol, 2011 Dec 29; 14(3). PMID: 22201597 Free PMC article. Review.
Phase I trial of tremelimumab in combination with short-term androgen deprivation in patients with PSA-recurrent prostate cancer. Douglas G McNeel, Heath A Smith, +4 authors, Glenn Liu. less Cancer Immunol Immunother, 2012 Jan 03; 61(7). PMID: 22210552 Free PMC article.
Cancer immunotherapy. Thomas F Gajewski. Mol Oncol, 2012 Jan 18; 6(2). PMID: 22248437 Free PMC article. Review.
Novel treatments for metastatic cutaneous melanoma and the management of emergent toxicities. Charlotte Lemech, Hendrik-Tobias Arkenau. Clin Med Insights Oncol, 2012 Jan 19; 6. PMID: 22253555 Free PMC article.
Immunotherapy earns its spot in the ranks of cancer therapy. Drew Pardoll, Charles Drake. J Exp Med, 2012 Feb 15; 209(2). PMID: 22330682 Free PMC article.
The monoclonal antibody to cytotoxic T lymphocyte antigen 4, ipilimumab, in the treatment of melanoma. Claire Verschraegen. Cancer Manag Res, 2012 Feb 22; 4. PMID: 22346364 Free PMC article.
Unmasking the immune recognition of prostate cancer with CTLA4 blockade. Serena S Kwek, Edward Cha, Lawrence Fong. Nat Rev Cancer, 2012 Mar 02; 12(4). PMID: 22378189 Free PMC article. Review.
Translatability scoring in drug development: eight case studies. Alexandra Wendler, Martin Wehling. J Transl Med, 2012 Mar 09; 10. PMID: 22397594 Free PMC article.
Ipilimumab: its potential in non-small cell lung cancer. Pascale Tomasini, Nataliya Khobta, Laurent Greillier, Fabrice Barlesi. Ther Adv Med Oncol, 2012 Mar 17; 4(2). PMID: 22423263 Free PMC article.
The blockade of immune checkpoints in cancer immunotherapy. Drew M Pardoll. Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437870 Free PMC article. Highly Cited. Review.
Antibody therapy of cancer. Andrew M Scott, Jedd D Wolchok, Lloyd J Old. Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437872 Highly Cited. Review.
Targeting immune checkpoints: releasing the restraints on anti-tumor immunity for patients with melanoma. Michael A Postow, James Harding, Jedd D Wolchok. Cancer J, 2012 Mar 29; 18(2). PMID: 22453017 Free PMC article. Review.
From genes to drugs: targeted strategies for melanoma. Keith T Flaherty, F Stephen Hodi, David E Fisher. Nat Rev Cancer, 2012 Apr 06; 12(5). PMID: 22475929 Highly Cited. Review.
Regulatory T cells in human ovarian cancer. Dong-Jun Peng, Rebecca Liu, Weiping Zou. J Oncol, 2012 Apr 07; 2012. PMID: 22481922 Free PMC article.
Therapeutic antibodies against cancer. Mark J Adler, Dimiter S Dimitrov. Hematol Oncol Clin North Am, 2012 Apr 24; 26(3). PMID: 22520975 Free PMC article. Review.
T-regulatory cells: key players in tumor immune escape and angiogenesis. Andrea Facciabene, Gregory T Motz, George Coukos. Cancer Res, 2012 May 03; 72(9). PMID: 22549946 Free PMC article. Highly Cited. Review.
Prostate cancer: combination of vaccine plus ipilimumab--safety and toxicity. Padmanee Sharma, Christopher Logothetis. Nat Rev Urol, 2012 May 09; 9(6). PMID: 22565371
State of the science: an update on renal cell carcinoma. Eric Jonasch, P Andrew Futreal, +13 authors, W Kimryn Rathmell. less Mol Cancer Res, 2012 May 29; 10(7). PMID: 22638109 Free PMC article. Review.
Cutting edge in medical management of cutaneous oncology. Kim Chong, Adil Daud, +2 authors, Susana Ortiz-Urda, Sarah T Arron, UCSF High Risk Skin Cancer Program. less Semin Cutan Med Surg, 2012 May 30; 31(2). PMID: 22640435 Free PMC article. Review.
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. Suzanne L Topalian, F Stephen Hodi, +27 authors, Mario Sznol. less N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658127 Free PMC article. Highly Cited.
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. Julie R Brahmer, Scott S Tykodi, +23 authors, Jon M Wigginton. less N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658128 Free PMC article. Highly Cited.
CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection. Rebecca Waitz, Marcella Fassò, James P Allison. Oncoimmunology, 2012 Jul 04; 1(4). PMID: 22754781 Free PMC article.
Novel anti-melanoma immunotherapies: disarming tumor escape mechanisms. Sivan Sapoznik, Ohad Hammer, +4 authors, Gal Markel. less Clin Dev Immunol, 2012 Jul 11; 2012. PMID: 22778766 Free PMC article. Review.
Modeling and predicting clinical efficacy for drugs targeting the tumor milieu. Mallika Singh, Napoleone Ferrara. Nat Biotechnol, 2012 Jul 12; 30(7). PMID: 22781694 Review.
Biomarkers on melanoma patient T cells associated with ipilimumab treatment. Wenshi Wang, Daohai Yu, +6 authors, Jeffrey S Weber. less J Transl Med, 2012 Jul 14; 10. PMID: 22788688 Free PMC article.
NFAT1 supports tumor-induced anergy of CD4(+) T cells. Brian T Abe, Daniel S Shin, Enric Mocholi, Fernando Macian. Cancer Res, 2012 Aug 07; 72(18). PMID: 22865456 Free PMC article.
Introduction to monoclonal antibodies. Jean-Pierre Mach. Cancer Immun, 2012 Aug 17; 12. PMID: 22896756 Free PMC article. Review.
Monoclonal antibodies in cancer therapy. Andrew M Scott, James P Allison, Jedd D Wolchok. Cancer Immun, 2012 Aug 17; 12. PMID: 22896759 Free PMC article. Highly Cited. Review.
Lung cancer: a classic example of tumor escape and progression while providing opportunities for immunological intervention. Martin R Jadus, Josephine Natividad, +6 authors, Maria G Dacosta-Iyer. less Clin Dev Immunol, 2012 Aug 18; 2012. PMID: 22899945 Free PMC article. Review.
Ipilimumab pharmacotherapy in patients with metastatic melanoma. Joanne M Jeter, Lee D Cranmer, Evan M Hersh. Clin Med Insights Oncol, 2012 Aug 21; 6. PMID: 22904648 Free PMC article.
Regulatory T cells in radiotherapeutic responses. Dörthe Schaue, Michael W Xie, Josephine A Ratikan, William H McBride. Front Oncol, 2012 Aug 23; 2. PMID: 22912933 Free PMC article.
MODULATING CO-STIMULATION DURING ANTIGEN PRESENTATION TO ENHANCE CANCER IMMUNOTHERAPY. Therese Liechtenstein, Ines Dufait, +2 authors, Alessio Lanna, Karine Breckpot, David Escors. less Immunol Endocr Metab Agents Med Chem, 2012 Sep 05; 12(3). PMID: 22945252 Free PMC article.
Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects. Maria Grazia Ruocco, Karsten A Pilones, +7 authors, Sandra Demaria. less J Clin Invest, 2012 Sep 05; 122(10). PMID: 22945631 Free PMC article. Highly Cited.
Diversity of antigen-specific responses induced in vivo with CTLA-4 blockade in prostate cancer patients. Serena S Kwek, Vinh Dao, +5 authors, Lawrence Fong. less J Immunol, 2012 Sep 08; 189(7). PMID: 22956585 Free PMC article.
Advances in the development of cancer immunotherapies. Jianjun Gao, Chantale Bernatchez, +2 authors, Padmanee Sharma, Laszlo G Radvanyi, Patrick Hwu. less Trends Immunol, 2012 Oct 04; 34(2). PMID: 23031830 Free PMC article. Review.
T cell coinhibition and immunotherapy in human breast cancer. Murali Janakiram, Yael M Abadi, Joseph A Sparano, Xingxing Zang. Discov Med, 2012 Nov 02; 14(77). PMID: 23114578 Free PMC article. Review.
CTLA-4-Tg/CD-28-KO Mice Exhibit Reduced T Cell Proliferation in vivo Compared to CD-28-KO Mice in a Graft-versus-host Disease Model. Jong-Sun Yoo, Yun-Jung Lee, +2 authors, Joo Won Yoon, Kyeong Eun Hyung, Kwang Woo Hwang. less Korean J Physiol Pharmacol, 2012 Nov 03; 16(5). PMID: 23118560 Free PMC article.
Immunology beats cancer: a blueprint for successful translation. Drew M Pardoll. Nat Immunol, 2012 Nov 20; 13(12). PMID: 23160205 Free PMC article.
Durable adoptive immunotherapy for leukemia produced by manipulation of multiple regulatory pathways of CD8+ T-cell tolerance. Melissa M Berrien-Elliott, Stephanie R Jackson, +6 authors, Ryan M Teague. less Cancer Res, 2012 Nov 29; 73(2). PMID: 23188506 Free PMC article.
Immunotherapies: the blockade of inhibitory signals. Yan-Ling Wu, Jing Liang, +2 authors, Wen Zhang, Yoshimasa Tanaka, Hiroshi Sugiyama. less Int J Biol Sci, 2012 Dec 01; 8(10). PMID: 23197939 Free PMC article. Review.
Suppression, subversion and escape: the role of regulatory T cells in cancer progression. K Oleinika, R J Nibbs, G J Graham, A R Fraser. Clin Exp Immunol, 2012 Dec 04; 171(1). PMID: 23199321 Free PMC article. Review.
Comparative antitumor effect of preventive versus therapeutic vaccines employing B16 melanoma cells genetically modified to express GM-CSF and B7.2 in a murine model. Antonio Miguel, María José Herrero, +4 authors, Salvador F Aliño. less Toxins (Basel), 2012 Dec 04; 4(11). PMID: 23202306 Free PMC article.
Immunosuppressive effect of regulatory T lymphocytes in lung cancer, with special reference to their effects on the induction of autologous tumor-specific cytotoxic T lymphocytes. Yoshiki Shigematsu, Takeshi Hanagiri, +8 authors, Fumihiro Tanaka. less Oncol Lett, 2012 Dec 04; 4(4). PMID: 23205074 Free PMC article.
Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer. Harald von Boehmer, Carolin Daniel. Nat Rev Drug Discov, 2013 Jan 01; 12(1). PMID: 23274471 Highly Cited. Review.
Molecular control of steady-state dendritic cell maturation and immune homeostasis. Gianna Elena Hammer, Averil Ma. Annu Rev Immunol, 2013 Jan 22; 31. PMID: 23330953 Free PMC article. Review.
Advances in targeting cell surface signalling molecules for immune modulation. Sheng Yao, Yuwen Zhu, Lieping Chen. Nat Rev Drug Discov, 2013 Feb 02; 12(2). PMID: 23370250 Free PMC article. Highly Cited. Review.
CTLA-4 blockade in tumor models: an overview of preclinical and translational research. Joseph F Grosso, Maria N Jure-Kunkel. Cancer Immun, 2013 Feb 08; 13. PMID: 23390376 Free PMC article. Highly Cited. Review.
Immunomodulatory therapy for melanoma: ipilimumab and beyond. Margaret K Callahan, Michael A Postow, Jedd D Wolchok. Clin Dermatol, 2013 Feb 27; 31(2). PMID: 23438382 Free PMC article. Review.
The nature of activatory and tolerogenic dendritic cell-derived signal II. Ghaith Bakdash, Simone P Sittig, +2 authors, Tjeerd van Dijk, Carl G Figdor, I Jolanda M de Vries. less Front Immunol, 2013 Mar 02; 4. PMID: 23450201 Free PMC article.
Agonist antibodies to TNFR molecules that costimulate T and NK cells. Ignacio Melero, Daniel Hirschhorn-Cymerman, +2 authors, Jedd D Wolchok. less Clin Cancer Res, 2013 Mar 06; 19(5). PMID: 23460535 Free PMC article. Highly Cited.
Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer. S A Quezada, K S Peggs. Br J Cancer, 2013 Mar 21; 108(8). PMID: 23511566 Free PMC article.
Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study. S F Slovin, C S Higano, +8 authors, T M Beer. less Ann Oncol, 2013 Mar 29; 24(7). PMID: 23535954 Free PMC article. Highly Cited.
Long-lasting complete regression of established mouse tumors by counteracting Th2 inflammation. Min Dai, Huafeng Wei, +5 authors, Karl Erik Hellstrom. less J Immunother, 2013 Apr 23; 36(4). PMID: 23603859 Free PMC article.
At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy. Andrew M Intlekofer, Craig B Thompson. J Leukoc Biol, 2013 Apr 30; 94(1). PMID: 23625198 Free PMC article. Highly Cited. Review.
The engagement of CTLA-4 on primary melanoma cell lines induces antibody-dependent cellular cytotoxicity and TNF-α production. Stefania Laurent, Paola Queirolo, +15 authors, Maria Pia Pistillo. less J Transl Med, 2013 May 03; 11. PMID: 23634660 Free PMC article.
T-cell tolerance in cancer. Roza Nurieva, Junmei Wang, Anupama Sahoo. Immunotherapy, 2013 May 04; 5(5). PMID: 23638746 Free PMC article. Review.
Immunomodulatory monoclonal antibodies combined with peptide vaccination provide potent immunotherapy in an aggressive murine neuroblastoma model. Emily L Williams, Stuart N Dunn, +4 authors, Juliet C Gray. less Clin Cancer Res, 2013 May 08; 19(13). PMID: 23649004 Free PMC article.
At the bedside: CTLA-4- and PD-1-blocking antibodies in cancer immunotherapy. Margaret K Callahan, Jedd D Wolchok. J Leukoc Biol, 2013 May 15; 94(1). PMID: 23667165 Free PMC article. Highly Cited. Review.
Ipilimumab, vemurafenib, dabrafenib, and trametinib: synergistic competitors in the clinical management of BRAF mutant malignant melanoma. Jason J Luke, F Stephen Hodi. Oncologist, 2013 May 28; 18(6). PMID: 23709751 Free PMC article. Review.
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Kipp Weiskopf, Aaron M Ring, +8 authors, K Christopher Garcia. less Science, 2013 Jun 01; 341(6141). PMID: 23722425 Free PMC article. Highly Cited.
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. Omid Hamid, Caroline Robert, +23 authors, Antoni Ribas. less N Engl J Med, 2013 Jun 04; 369(2). PMID: 23724846 Free PMC article. Highly Cited.
Depleting tumor-specific Tregs at a single site eradicates disseminated tumors. Aurélien Marabelle, Holbrook Kohrt, +13 authors, Ronald Levy. less J Clin Invest, 2013 Jun 04; 123(6). PMID: 23728179 Free PMC article. Highly Cited.
Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. Rikke B Holmgaard, Dmitriy Zamarin, +2 authors, David H Munn, Jedd D Wolchok, James P Allison. less J Exp Med, 2013 Jun 12; 210(7). PMID: 23752227 Free PMC article. Highly Cited.
Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma. Jedd D Wolchok, F Stephen Hodi, +9 authors, Alan J Korman. less Ann N Y Acad Sci, 2013 Jun 19; 1291. PMID: 23772560 Free PMC article. Highly Cited. Review.
An enhanced heterologous virus-like particle for human papillomavirus type 16 tumour immunotherapy. Khairunadwa Jemon, Vivienne Young, +5 authors, Merilyn Hibma. less PLoS One, 2013 Jun 27; 8(6). PMID: 23799135 Free PMC article.
Immunosuppressive microenvironment in neuroblastoma. Vito Pistoia, Fabio Morandi, +3 authors, Lizzia Raffaghello. less Front Oncol, 2013 Jun 28; 3. PMID: 23805414 Free PMC article.
Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy. Christopher J Nirschl, Charles G Drake. Clin Cancer Res, 2013 Jul 23; 19(18). PMID: 23868869 Free PMC article. Highly Cited. Review.
Therapeutic cancer vaccines: past, present, and future. Chunqing Guo, Masoud H Manjili, +3 authors, Xiang-Yang Wang. less Adv Cancer Res, 2013 Jul 23; 119. PMID: 23870514 Free PMC article. Highly Cited. Review.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981 Free PMC article. Highly Cited.
Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. Yannick Bulliard, Rose Jolicoeur, +6 authors, Jennifer L Brogdon. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897982 Free PMC article. Highly Cited.
Correlation between B7-H3 expression and matrix metalloproteinases 2 expression in pancreatic cancer. Lihua Xu, Xiangmin Ding, Huo Tan, Jianjun Qian. Cancer Cell Int, 2013 Aug 21; 13(1). PMID: 23947693 Free PMC article.
Use of ipilimumab in the treatment of melanoma. Utkarsh H Acharya, Joanne M Jeter. Clin Pharmacol, 2013 Oct 12; 5(Suppl 1). PMID: 24113540 Free PMC article. Review.
Differential CTLA-4 expression in human CD4+ versus CD8+ T cells is associated with increased NFAT1 and inhibition of CD4+ proliferation. D V Chan, H M Gibson, +4 authors, H K Wong. less Genes Immun, 2013 Nov 01; 15(1). PMID: 24173147 Free PMC article.
Anti-cytotoxic T lymphocyte antigen-4 antibodies in melanoma. Giulio Tosti, Emilia Cocorocchio, Elisabetta Pennacchioli. Clin Cosmet Investig Dermatol, 2013 Nov 10; 6. PMID: 24204168 Free PMC article. Review.
Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer. Charles G Drake, Evan J Lipson, Julie R Brahmer. Nat Rev Clin Oncol, 2013 Nov 20; 11(1). PMID: 24247168 Free PMC article. Highly Cited. Review.
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Christine Feig, James O Jones, +12 authors, Douglas T Fearon. less Proc Natl Acad Sci U S A, 2013 Nov 28; 110(50). PMID: 24277834 Free PMC article. Highly Cited.
Recent developments in the treatment of renal cell carcinoma. Janice P Dutcher. Ther Adv Urol, 2013 Dec 03; 5(6). PMID: 24294292 Free PMC article. Review.
Association between cytotoxic T lymphocyte antigen-4 +49A/G, -1722T/C, and -1661A/G polymorphisms and cancer risk: a meta-analysis. Rui Geng, Fanglong Song, +5 authors, Weimin Fan. less Tumour Biol, 2013 Dec 07; 35(4). PMID: 24307627
Cancer immunotherapy: are we there yet? Zihai Li, Lieping Chen, Mark P Rubinstein. Exp Hematol Oncol, 2013 Dec 12; 2(1). PMID: 24326015 Free PMC article.
Clinical Implications of Co-Inhibitory Molecule Expression in the Tumor Microenvironment for DC Vaccination: A Game of Stop and Go. Angela Vasaturo, Stefania Di Blasio, +4 authors, Stanleyson V Hato. less Front Immunol, 2013 Dec 19; 4. PMID: 24348481 Free PMC article. Review.
Association between CTLA-4 60G/A and -1661A/G polymorphisms and the risk of cancers: a meta-analysis. Qing Yan, Pin Chen, +2 authors, Ailin Lu, Peng Zhao, Aihua Gu. less PLoS One, 2014 Jan 01; 8(12). PMID: 24376736 Free PMC article.
BRAF and MEK gene rearrangements in melanoma: implications for targeted therapy. Pedro Madureira, Ramon Andrade de Mello. Mol Diagn Ther, 2014 Jan 10; 18(3). PMID: 24403169 Review.
Paradoxical activation of T cells via augmented ERK signaling mediated by a RAF inhibitor. Margaret K Callahan, Gregg Masters, +13 authors, Jedd D Wolchok. less Cancer Immunol Res, 2014 Jan 15; 2(1). PMID: 24416731 Free PMC article.
Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer. David C Binder, Boris Engels, +11 authors, Hans Schreiber. less Cancer Immunol Res, 2014 Jan 24; 1(2). PMID: 24455752 Free PMC article.
Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression. Shannon K Oda, Pamela Strauch, +5 authors, Raul M Torres. less Cancer Immunol Res, 2014 Jan 24; 1(4). PMID: 24455753 Free PMC article.
In vivo discovery of immunotherapy targets in the tumour microenvironment. Penghui Zhou, Donald R Shaffer, +17 authors, Kai W Wucherpfennig. less Nature, 2014 Jan 31; 506(7486). PMID: 24476824 Free PMC article. Highly Cited.
PD-L1 Expression in Clear Cell Renal Cell Carcinoma: An Analysis of Nephrectomy and Sites of Metastases. L B Jilaveanu, B Shuch, +5 authors, H M Kluger. less J Cancer, 2014 Feb 25; 5(3). PMID: 24563671 Free PMC article.
Immune checkpoint blockade: the hope for immunotherapy as a treatment of lung cancer? Julie R Brahmer. Semin Oncol, 2014 Feb 26; 41(1). PMID: 24565586 Free PMC article. Review.
Local hyperthermia treatment of tumors induces CD8(+) T cell-mediated resistance against distal and secondary tumors. Seiko Toraya-Brown, Mee Rie Sheen, +7 authors, Steven Fiering. less Nanomedicine, 2014 Feb 26; 10(6). PMID: 24566274 Free PMC article.
Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an "innocent bystander". Lucia Gelao, Carmen Criscitiello, +2 authors, Angela Esposito, Aron Goldhirsch, Giuseppe Curigliano. less Toxins (Basel), 2014 Mar 07; 6(3). PMID: 24594636 Free PMC article. Review.
Efficacy and safety of ipilimumab therapy in patients with metastatic melanoma: a retrospective multicenter analysis. Katarzyna Wiater, Tomasz Switaj, +7 authors, Piotr Rutkowski. less Contemp Oncol (Pozn), 2013 Jan 01; 17(3). PMID: 24596511 Free PMC article.
Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy. Dmitriy Zamarin, Rikke B Holmgaard, +6 authors, James P Allison. less Sci Transl Med, 2014 Mar 07; 6(226). PMID: 24598590 Free PMC article. Highly Cited.
Armed therapeutic viruses - a disruptive therapy on the horizon of cancer immunotherapy. Maxine Bauzon, Terry Hermiston. Front Immunol, 2014 Mar 08; 5. PMID: 24605114 Free PMC article. Review.
Host immune response to infection and cancer: unexpected commonalities. Romina S Goldszmid, Amiran Dzutsev, Giorgio Trinchieri. Cell Host Microbe, 2014 Mar 19; 15(3). PMID: 24629336 Free PMC article. Review.
Tumour immunogenicity, antigen presentation and immunological barriers in cancer immunotherapy. David Escors. New J Sci, 2014 Mar 19; 2014. PMID: 24634791 Free PMC article.
Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model. Raffaella Iannone, Lucio Miele, +2 authors, Piera Maiolino, Aldo Pinto, Silvana Morello. less Am J Cancer Res, 2014 Mar 25; 4(2). PMID: 24660106 Free PMC article.
Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy. Xiaozhou Fan, Sergio A Quezada, +2 authors, Manuel A Sepulveda, Padmanee Sharma, James P Allison. less J Exp Med, 2014 Apr 02; 211(4). PMID: 24687957 Free PMC article. Highly Cited.
Unmet needs in squamous cell carcinoma of the lung: potential role for immunotherapy. Thomas E Stinchcombe. Med Oncol, 2014 Apr 22; 31(5). PMID: 24748366 Free PMC article. Review.
Apoptosis-regulated low-avidity cancer-specific CD8(+) T cells can be rescued to eliminate HER2/neu-expressing tumors by costimulatory agonists in tolerized mice. Chelsea M Black, Todd D Armstrong, Elizabeth M Jaffee. Cancer Immunol Res, 2014 Apr 26; 2(4). PMID: 24764578 Free PMC article.
Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti-CTLA-4 therapy. Derek Ng Tang, Yu Shen, +5 authors, Padmanee Sharma. less Cancer Immunol Res, 2014 Apr 30; 1(4). PMID: 24777852 Free PMC article. Highly Cited.
CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy. Hong Chen, Tihui Fu, +7 authors, Padmanee Sharma. less Cancer Immunol Res, 2014 Apr 30; 2(2). PMID: 24778280 Free PMC article.
Paradigm Shift in Dendritic Cell-Based Immunotherapy: From in vitro Generated Monocyte-Derived DCs to Naturally Circulating DC Subsets. Florian Wimmers, Gerty Schreibelt, +2 authors, Annette E Sköld, Carl G Figdor, I Jolanda M De Vries. less Front Immunol, 2014 May 02; 5. PMID: 24782868 Free PMC article. Review.
A novel pancreatic β-cell targeting bispecific-antibody (BsAb) can prevent the development of type 1 diabetes in NOD mice. Palash Bhattacharya, Jilao Fan, +5 authors, Bellur S Prabhakar. less Clin Immunol, 2014 May 06; 153(1). PMID: 24792135 Free PMC article.
Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients. Edward Cha, Mark Klinger, +4 authors, Lawrence Fong. less Sci Transl Med, 2014 May 30; 6(238). PMID: 24871131 Free PMC article. Highly Cited.
Blocking immunosuppressive checkpoints for glioma therapy: the more the Merrier! Maria G Castro, Gregory J Baker, Pedro R Lowenstein. Clin Cancer Res, 2014 Jun 01; 20(20). PMID: 24879798 Free PMC article.
CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells. Andreas Herrmann, Saul J Priceman, +10 authors, Hua Yu. less J Clin Invest, 2014 Jun 04; 124(7). PMID: 24892807 Free PMC article.
Opportunistic Autoimmune Disorders Potentiated by Immune-Checkpoint Inhibitors Anti-CTLA-4 and Anti-PD-1. Yi-Chi M Kong, Jeffrey C Flynn. Front Immunol, 2014 Jun 07; 5. PMID: 24904570 Free PMC article. Review.
Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment. Mary B Mockler, Melissa J Conroy, Joanne Lysaght. Front Oncol, 2014 Jun 07; 4. PMID: 24904823 Free PMC article. Review.
Current trends in glioblastoma multiforme treatment: radiation therapy and immune checkpoint inhibitors. Sarah Nicholas, Dimitris Mathios, +3 authors, Michael Lim. less Brain Tumor Res Treat, 2013 Apr 01; 1(1). PMID: 24904882 Free PMC article. Review.
Induced regulatory T cells in inhibitory microenvironments created by cancer. Theresa L Whiteside. Expert Opin Biol Ther, 2014 Jun 18; 14(10). PMID: 24934899 Free PMC article. Review.
Vemurafenib: an evidence-based review of its clinical utility in the treatment of metastatic melanoma. Abhisek Swaika, Jennifer A Crozier, Richard W Joseph. Drug Des Devel Ther, 2014 Jun 27; 8. PMID: 24966667 Free PMC article. Review.
Tackling the cancer stem cells - what challenges do they pose? Diwakar R Pattabiraman, Robert A Weinberg. Nat Rev Drug Discov, 2014 Jul 02; 13(7). PMID: 24981363 Free PMC article. Highly Cited. Review.
Ipilimumab augments antitumor activity of bispecific antibody-armed T cells. Hiroshi Yano, Archana Thakur, +3 authors, Lawrence G Lum. less J Transl Med, 2014 Jul 11; 12. PMID: 25008236 Free PMC article.
Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model. Zineb Belcaid, Jillian A Phallen, +17 authors, Michael Lim. less PLoS One, 2014 Jul 12; 9(7). PMID: 25013914 Free PMC article. Highly Cited.
Tumor-specific oncolytic adenoviruses expressing granulocyte macrophage colony-stimulating factor or anti-CTLA4 antibody for the treatment of cancers. T Du, G Shi, +5 authors, D C Yu. less Cancer Gene Ther, 2014 Jul 19; 21(8). PMID: 25034886
PD-1 as an emerging therapeutic target in renal cell carcinoma: current evidence. Scott S Tykodi. Onco Targets Ther, 2014 Aug 13; 7. PMID: 25114573 Free PMC article. Review.
Curing mice with large tumors by locally delivering combinations of immunomodulatory antibodies. Min Dai, Yuen Yee Yip, Ingegerd Hellstrom, Karl Erik Hellstrom. Clin Cancer Res, 2014 Aug 22; 21(5). PMID: 25142145 Free PMC article.
No longer an untreatable disease: how targeted and immunotherapies have changed the management of melanoma patients. Maria Romina Girotti, Grazia Saturno, Paul Lorigan, Richard Marais. Mol Oncol, 2014 Sep 03; 8(6). PMID: 25178978 Free PMC article. Review.
Combining radiation and immunotherapy: a new systemic therapy for solid tumors? Chad Tang, Xiaohong Wang, +14 authors, James W Welsh. less Cancer Immunol Res, 2014 Sep 05; 2(9). PMID: 25187273 Free PMC article. Highly Cited. Review.
Immune checkpoint inhibitors in clinical trials. Elad Sharon, Howard Streicher, Priscila Goncalves, Helen X Chen. Chin J Cancer, 2014 Sep 06; 33(9). PMID: 25189716 Free PMC article. Review.
Modeling putative therapeutic implications of exosome exchange between tumor and immune cells. Mingyang Lu, Bin Huang, +2 authors, Samir M Hanash, José N Onuchic, Eshel Ben-Jacob. less Proc Natl Acad Sci U S A, 2014 Sep 24; 111(40). PMID: 25246552 Free PMC article.
Immune suppressive effect of cinnamaldehyde due to inhibition of proliferation and induction of apoptosis in immune cells: implications in cancer. Franziska Roth-Walter, Anna Moskovskich, +6 authors, Erika Jensen-Jarolim. less PLoS One, 2014 Oct 02; 9(10). PMID: 25271635 Free PMC article.
Intratumoral checkpoint subversion as a strategy for minimizing adverse effects: Harvesting the power of TILs without harvesting TILs. Leah Alabanza, Sacha Gnjatic, Nina Bhardwaj, Joshua Brody. Oncoimmunology, 2014 Oct 24; 3. PMID: 25339995 Free PMC article.
Victory and defeat in the induction of a therapeutic response through vaccine therapy for human and canine brain tumors: a review of the state of the art. Michael R Olin, G Elizabeth Pluhar, +3 authors, Christopher L Moertel. less Crit Rev Immunol, 2014 Nov 19; 34(5). PMID: 25404047 Free PMC article. Review.
Drug development: a chance of survival. Hannah Hoag. Nature, 2014 Nov 20; 515(7527). PMID: 25407709
Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Miranda L Broz, Mikhail Binnewies, +12 authors, Matthew F Krummel. less Cancer Cell, 2014 Dec 03; 26(5). PMID: 25446897 Free PMC article. Highly Cited.
Immunologic checkpoints in cancer therapy: focus on the programmed death-1 (PD-1) receptor pathway. Parisa Momtaz, Michael A Postow. Pharmgenomics Pers Med, 2014 Dec 09; 7. PMID: 25484597 Free PMC article. Review.
Balance and imbalance in the immune system: life on the edge. Suzanne L Topalian, Arlene H Sharpe. Immunity, 2014 Dec 18; 41(5). PMID: 25517610 Free PMC article.
Molecularly targeted therapies in non-small-cell lung cancer annual update 2014. Daniel Morgensztern, Meghan J Campo, +21 authors, Ramaswamy Govindan. less J Thorac Oncol, 2014 Dec 24; 10(1 Suppl 1). PMID: 25535693 Free PMC article.
Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4. Helga Schneider, Christopher E Rudd. Front Immunol, 2014 Dec 30; 5. PMID: 25538704 Free PMC article. Review.
CD80-CD28 signaling controls the progression of inflammatory colorectal carcinogenesis. Marco Scarpa, Paola Brun, +13 authors, Carlo Castoro. less Oncotarget, 2015 Jan 18; 6(24). PMID: 25595911 Free PMC article.
Immune Checkpoint Blockade in Cancer Therapy. Michael A Postow, Margaret K Callahan, Jedd D Wolchok. J Clin Oncol, 2015 Jan 22; 33(17). PMID: 25605845 Free PMC article. Highly Cited. Review.
Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma. Ziming Du, Malak Abedalthagafi, +16 authors, Sandro Santagata. less Oncotarget, 2015 Jan 23; 6(7). PMID: 25609200 Free PMC article.
The mouse NKR-P1B:Clr-b recognition system is a negative regulator of innate immune responses. Mir Munir A Rahim, Peter Chen, +8 authors, Andrew P Makrigiannis. less Blood, 2015 Jan 24; 125(14). PMID: 25612621 Free PMC article.
CTLA-4 and PD-1 Pathway Blockade: Combinations in the Clinic. Margaret K Callahan, Michael A Postow, Jedd D Wolchok. Front Oncol, 2015 Feb 03; 4. PMID: 25642417 Free PMC article. Highly Cited. Review.
Review of immune-related adverse events in prostate cancer patients treated with ipilimumab: MD Anderson experience. J Gao, Q He, +6 authors, P Sharma. less Oncogene, 2015 Feb 11; 34(43). PMID: 25659583 Free PMC article. Review.
New and emerging therapeutic options for malignant pleural mesothelioma: review of early clinical trials. Svetlana Kotova, Raymond M Wong, Robert B Cameron. Cancer Manag Res, 2015 Feb 12; 7. PMID: 25670913 Free PMC article. Review.
Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma. Rafael Winograd, Katelyn T Byrne, +8 authors, Robert H Vonderheide. less Cancer Immunol Res, 2015 Feb 14; 3(4). PMID: 25678581 Free PMC article. Highly Cited.
Glioblastoma stem cells and stem cell-targeting immunotherapies. Rogelio Esparza, Tej D Azad, +2 authors, Samuel H Cheshier. less J Neurooncol, 2015 Feb 16; 123(3). PMID: 25682090 Review.
Combining immunotherapy with oncogene-targeted therapy: a new road for melanoma treatment. Mariana Aris, María Marcela Barrio. Front Immunol, 2015 Feb 25; 6. PMID: 25709607 Free PMC article. Review.
Immunotherapy for lung cancer: for whom the bell tolls? Pedro Madureira, Ramon Andrade de Mello, Alessandro de Vasconcelos, Yan Zhang. Tumour Biol, 2015 Mar 05; 36(3). PMID: 25736929 Review.
The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma. Pengyuan Yang, Geoffrey J Markowitz, Xiao-Fan Wang. Natl Sci Rev, 2015 Mar 06; 1(3). PMID: 25741453 Free PMC article.
The role of checkpoints in the treatment of GBM. Jennifer E Kim, Michael Lim. J Neurooncol, 2015 Mar 10; 123(3). PMID: 25749875 Free PMC article.
Nivolumab in melanoma: latest evidence and clinical potential. Douglas B Johnson, Chengwei Peng, Jeffrey A Sosman. Ther Adv Med Oncol, 2015 Mar 11; 7(2). PMID: 25755682 Free PMC article. Review.
OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal. Stefanie N Linch, Michael J McNamara, William L Redmond. Front Oncol, 2015 Mar 13; 5. PMID: 25763356 Free PMC article. Highly Cited. Review.
Immune approaches to the treatment of breast cancer, around the corner? Carmen Criscitiello, Angela Esposito, +6 authors, Giuseppe Curigliano. less Breast Cancer Res, 2014 Jan 01; 16(1). PMID: 25774617 Free PMC article. Review.
Immune checkpoint blockade: a common denominator approach to cancer therapy. Suzanne L Topalian, Charles G Drake, Drew M Pardoll. Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858804 Free PMC article. Highly Cited. Review.
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Padmanee Sharma, James P Allison. Cell, 2015 Apr 11; 161(2). PMID: 25860605 Free PMC article. Highly Cited. Review.
Ipilimumab and immune-mediated adverse events: a case report of anti-CTLA4 induced ileitis. Olga Venditti, Delia De Lisi, +9 authors, Daniele Santini. less BMC Cancer, 2015 Apr 18; 15. PMID: 25885696 Free PMC article.
Immune Mechanisms Are Major Players in Cancer. Karl Erik Hellstrom, Ingegerd Hellstrom. Clin Cancer Res, 2015 Apr 24; 21(16). PMID: 25904750 Free PMC article.
Checkpoint modulation--A new way to direct the immune system against renal cell carcinoma. Jens Bedke, Stephan Kruck, +2 authors, Georgios Gakis, Arnulf Stenzl, Peter J Goebell. less Hum Vaccin Immunother, 2015 Apr 29; 11(5). PMID: 25912622 Free PMC article. Review.
Late onset ipilimumab-induced pericarditis and pericardial effusion: a rare but life threatening complication. Seongseok Yun, Nicole D Vincelette, +2 authors, Iyad Mansour, Dana Hariri, Sara Motamed. less Case Rep Oncol Med, 2015 Apr 29; 2015. PMID: 25918658 Free PMC article.
Cancer immunotherapy and immune-related response assessment: The role of radiologists in the new arena of cancer treatment. Mizuki Nishino, Sree H Tirumani, Nikhil H Ramaiya, F Stephen Hodi. Eur J Radiol, 2015 May 06; 84(7). PMID: 25937524 Free PMC article. Review.
A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy. Robert D Leone, Ying-Chun Lo, Jonathan D Powell. Comput Struct Biotechnol J, 2015 May 06; 13. PMID: 25941561 Free PMC article. Highly Cited. Review.
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses. Jun Liu, Ying Yuan, +8 authors, Li Wang. less Proc Natl Acad Sci U S A, 2015 May 13; 112(21). PMID: 25964334 Free PMC article. Highly Cited.
Preexisting Levels of CD4 T Cells Expressing PD-1 Are Related to Overall Survival in Prostate Cancer Patients Treated with Ipilimumab. Serena S Kwek, Jera Lewis, +7 authors, Lawrence Fong. less Cancer Immunol Res, 2015 May 15; 3(9). PMID: 25968455 Free PMC article.
Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy. Keishi Adachi, Koji Tamada. Cancer Sci, 2015 May 20; 106(8). PMID: 25981182 Free PMC article. Review.
Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia. Hanna A Knaus, Christopher G Kanakry, Leo Luznik, Ivana Gojo. Curr Drug Targets, 2015 May 20; 18(3). PMID: 25981611 Free PMC article. Review.
Perforin and granzymes: function, dysfunction and human pathology. Ilia Voskoboinik, James C Whisstock, Joseph A Trapani. Nat Rev Immunol, 2015 May 23; 15(6). PMID: 25998963 Highly Cited. Review.
Two heads better than one? Ipilimumab immunotherapy and radiation therapy for melanoma brain metastases. Kirtesh R Patel, David H Lawson, +5 authors, Mohammad K Khan. less Neuro Oncol, 2015 May 28; 17(10). PMID: 26014049 Free PMC article. Review.
Inhibitory receptors as targets for cancer immunotherapy. Meghan E Turnis, Lawrence P Andrews, Dario A A Vignali. Eur J Immunol, 2015 May 29; 45(7). PMID: 26018646 Free PMC article. Review.
Programmed death-1 checkpoint blockade in acute myeloid leukemia. Alison Sehgal, Theresa L Whiteside, Michael Boyiadzis. Expert Opin Biol Ther, 2015 Jun 04; 15(8). PMID: 26036819 Free PMC article. Review.
Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy. Rosa Barreira da Silva, Melissa E Laird, +3 authors, Matthew L Albert. less Nat Immunol, 2015 Jun 16; 16(8). PMID: 26075911 Highly Cited.
Rationale for a Multimodality Strategy to Enhance the Efficacy of Dendritic Cell-Based Cancer Immunotherapy. Jashodeep Datta, Erik Berk, +3 authors, Brian J Czerniecki. less Front Immunol, 2015 Jun 18; 6. PMID: 26082780 Free PMC article. Review.
Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers. Luisa Carbognin, Sara Pilotto, +11 authors, Giampaolo Tortora. less PLoS One, 2015 Jun 19; 10(6). PMID: 26086854 Free PMC article. Highly Cited.
Radiographic Profiling of Immune-Related Adverse Events in Advanced Melanoma Patients Treated with Ipilimumab. Sree Harsha Tirumani, Nikhil H Ramaiya, +4 authors, Mizuki Nishino. less Cancer Immunol Res, 2015 Jun 24; 3(10). PMID: 26100356 Free PMC article.
Viral Infection of Tumors Overcomes Resistance to PD-1-immunotherapy by Broadening Neoantigenome-directed T-cell Responses. Norman Woller, Engin Gürlevik, +9 authors, Florian Kühnel. less Mol Ther, 2015 Jun 27; 23(10). PMID: 26112079 Free PMC article. Highly Cited.
In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment. Claire Vanpouille-Box, Karsten A Pilones, +2 authors, Erik Wennerberg, Silvia C Formenti, Sandra Demaria. less Vaccine, 2015 Jul 08; 33(51). PMID: 26148880 Free PMC article. Review.
Clinical Development of Immune Checkpoint Inhibitors. Ayumu Ito, Shunsuke Kondo, Kohei Tada, Shigehisa Kitano. Biomed Res Int, 2015 Jul 15; 2015. PMID: 26161407 Free PMC article. Review.
Clinicopathologic analysis of programmed cell death-1 and programmed cell death-ligand 1 and 2 expressions in pulmonary adenocarcinoma: comparison with histology and driver oncogenic alteration status. Jaemoon Koh, Heounjeong Go, +9 authors, Doo Hyun Chung. less Mod Pathol, 2015 Jul 18; 28(9). PMID: 26183759
Defining Effective Combinations of Immune Checkpoint Blockade and Oncolytic Virotherapy. Juan J Rojas, Padma Sampath, Weizhou Hou, Steve H Thorne. Clin Cancer Res, 2015 Jul 19; 21(24). PMID: 26187615 Free PMC article. Highly Cited.
Editorial: "Cancer Immunotherapy: Lights and Shadows". María Marcela Barrio, Estrella Mariel Levy, José Mordoh. Front Immunol, 2015 Jul 29; 6. PMID: 26217342 Free PMC article.
Melanoma: From Incurable Beast to a Curable Bet. The Success of Immunotherapy. Maria Libera Ascierto, Ignacio Melero, Paolo Antonio Ascierto. Front Oncol, 2015 Jul 29; 5. PMID: 26217587 Free PMC article. Review.
Immunosuppressive Mechanisms of Malignant Gliomas: Parallels at Non-CNS Sites. Powell Perng, Michael Lim. Front Oncol, 2015 Jul 29; 5. PMID: 26217588 Free PMC article. Review.
Associations between CTLA-4 +49 A/G (rs231775) polymorphism and cancer risk: a meta-analysis based on 52 case-control studies. Lu Wang, Zhiwei Jiang, +3 authors, Hao Qiu, Weifeng Tang, Tanghai Duan, Lixin Wang. less Int J Clin Exp Med, 2015 Jul 30; 8(5). PMID: 26221222 Free PMC article.
Immunotherapy treatments for small-cell lung cancer: past, present and future. Matthew Whitehurst, Alberto Chiappori. Lung Cancer Manag, 2013 Jan 01; 2(6). PMID: 26236401 Free PMC article.
Tumor neoantigens: building a framework for personalized cancer immunotherapy. Matthew M Gubin, Maxim N Artyomov, Elaine R Mardis, Robert D Schreiber. J Clin Invest, 2015 Aug 11; 125(9). PMID: 26258412 Free PMC article. Highly Cited. Review.
Molecular Targeted Intervention for Pancreatic Cancer. Altaf Mohammed, Naveena B Janakiram, Shubham Pant, Chinthalapally V Rao. Cancers (Basel), 2015 Aug 13; 7(3). PMID: 26266422 Free PMC article. Review.
Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia. Nathan A Koonce, Joseph Levy, +6 authors, Robert J Griffin. less PLoS One, 2015 Aug 27; 10(8). PMID: 26308944 Free PMC article.
Strategies for combining immunotherapy with radiation for anticancer therapy. Steven N Seyedin, Jonathan E Schoenhals, +14 authors, James W Welsh. less Immunotherapy, 2015 Aug 28; 7(9). PMID: 26310908 Free PMC article. Review.
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Katherine B Chiappinelli, Pamela L Strissel, +20 authors, Reiner Strick. less Cell, 2015 Sep 01; 162(5). PMID: 26317466 Free PMC article. Highly Cited.
Cancer immunotherapy: harnessing the immune system to battle cancer. Yiping Yang. J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325031 Free PMC article. Highly Cited. Review.
Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade. Elizabeth Buchbinder, F Stephen Hodi. J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325034 Free PMC article. Review.
Cancer targeted therapeutics: From molecules to drug delivery vehicles. Daxing Liu, Debra T Auguste. J Control Release, 2015 Sep 08; 219. PMID: 26342659 Free PMC article.
Cancer immunotherapy innovator James Allison receives the 2015 Lasker~DeBakey Clinical Medical Research Award. Jillian H Hurst. J Clin Invest, 2015 Sep 09; 125(10). PMID: 26345422 Free PMC article.
Immunology and Immunotherapy of Head and Neck Cancer. Robert L Ferris. J Clin Oncol, 2015 Sep 10; 33(29). PMID: 26351330 Free PMC article. Highly Cited. Review.
Several immune escape patterns in non-Hodgkin's lymphomas. Camille Laurent, Konstantina Charmpi, +7 authors, Jean-Jacques Fournié. less Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405585 Free PMC article.
Phase II study of the immune-checkpoint inhibitor ipilimumab plus dacarbazine in Japanese patients with previously untreated, unresectable or metastatic melanoma. N Yamazaki, H Uhara, +8 authors, T Tokudome. less Cancer Chemother Pharmacol, 2015 Sep 27; 76(5). PMID: 26407818 Free PMC article.
Phase II study of ipilimumab monotherapy in Japanese patients with advanced melanoma. N Yamazaki, Y Kiyohara, +8 authors, T Tokudome. less Cancer Chemother Pharmacol, 2015 Sep 28; 76(5). PMID: 26410424 Free PMC article.
Signaling pathway and dysregulation of PD1 and its ligands in lymphoid malignancies. Yi Xia, L Jeffrey Medeiros, Ken H Young. Biochim Biophys Acta, 2015 Oct 04; 1865(1). PMID: 26432723 Free PMC article. Review.
Intellectual property issues of immune checkpoint inhibitors. Ulrich Storz. MAbs, 2015 Oct 16; 8(1). PMID: 26466763 Free PMC article.
Concepts and mechanisms underlying chemotherapy induced immunogenic cell death: impact on clinical studies and considerations for combined therapies. Simon Gebremeskel, Brent Johnston. Oncotarget, 2015 Oct 22; 6(39). PMID: 26486085 Free PMC article. Review.
Immune checkpoint inhibitors: a new frontier in bladder cancer. Max Kates, Nikolai A Sopko, +3 authors, Trinity J Bivalacqua. less World J Urol, 2015 Oct 22; 34(1). PMID: 26487055 Review.
Immune checkpoints and immunotherapy for colorectal cancer. Preet Paul Singh, Piyush K Sharma, Gayathri Krishnan, A Craig Lockhart. Gastroenterol Rep (Oxf), 2015 Oct 30; 3(4). PMID: 26510455 Free PMC article.
Immunomodulation: checkpoint blockade etc. William T Curry, Michael Lim. Neuro Oncol, 2015 Oct 31; 17 Suppl 7. PMID: 26516223 Free PMC article. Review.
Novel immunotherapies in lymphoid malignancies. Connie Lee Batlevi, Eri Matsuki, Renier J Brentjens, Anas Younes. Nat Rev Clin Oncol, 2015 Nov 04; 13(1). PMID: 26525683 Free PMC article. Highly Cited. Review.
Phase I Clinical Trial of Ipilimumab in Pediatric Patients with Advanced Solid Tumors. Melinda S Merchant, Matthew Wright, +9 authors, Crystal L Mackall. less Clin Cancer Res, 2015 Nov 05; 22(6). PMID: 26534966 Free PMC article.
Immune-checkpoint blockade: the springboard for immuno-combination therapy. A M Ibrahim, Y Wang, N R Lemoine. Gene Ther, 2015 Nov 06; 22(11). PMID: 26537748
Cancer immunotherapy: Strategies for personalization and combinatorial approaches. Vishwanath Sathyanarayanan, Sattva S Neelapu. Mol Oncol, 2015 Nov 10; 9(10). PMID: 26548534 Free PMC article. Review.
CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition. Elizabeth I Buchbinder, Anupam Desai. Am J Clin Oncol, 2015 Nov 13; 39(1). PMID: 26558876 Free PMC article. Highly Cited. Review.
Emerging targets in cancer immunotherapy: beyond CTLA-4 and PD-1. Amer Assal, Justin Kaner, Gopichand Pendurti, Xingxing Zang. Immunotherapy, 2015 Nov 17; 7(11). PMID: 26567614 Free PMC article. Review.
Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy. Anna Śledzińska, Laurie Menger, +2 authors, Katharina Bergerhoff, Karl S Peggs, Sergio A Quezada. less Mol Oncol, 2015 Nov 19; 9(10). PMID: 26578451 Free PMC article. Review.
Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy. Vinod Vijay Subhash, Mei Shi Yeo, Woei Loon Tan, Wei Peng Yong. J Immunol Res, 2015 Nov 19; 2015. PMID: 26579545 Free PMC article. Review.
Immunology: Another shot at cancer. Charles Schmidt. Nature, 2015 Nov 19; 527(7578). PMID: 26580157
Harnessing the Power of Onco-Immunotherapy with Checkpoint Inhibitors. Karishma R Rajani, Richard G Vile. Viruses, 2015 Nov 19; 7(11). PMID: 26580645 Free PMC article. Review.
Nanotechnologies for biomedical science and translational medicine. James R Heath. Proc Natl Acad Sci U S A, 2015 Nov 26; 112(47). PMID: 26598663 Free PMC article. Review.
Melanoma: oncogenic drivers and the immune system. Niki Karachaliou, Sara Pilotto, +10 authors, Rafael Rosell. less Ann Transl Med, 2015 Nov 26; 3(18). PMID: 26605311 Free PMC article. Review.
Current evidence on the cytotoxic T-lymphocyte antigen 4 + 49G > A polymorphism and digestive system cancer risks: a meta-analysis involving 11,923 subjects. Liu Xiaolei, Yang Baohong, +10 authors, Yu Guohua. less Meta Gene, 2015 Dec 03; 6. PMID: 26629416 Free PMC article.
Clinical relevance of host immunity in breast cancer: from TILs to the clinic. Peter Savas, Roberto Salgado, +4 authors, Sherene Loi. less Nat Rev Clin Oncol, 2015 Dec 17; 13(4). PMID: 26667975 Highly Cited. Review.
Single-cell analysis tools for drug discovery and development. James R Heath, Antoni Ribas, Paul S Mischel. Nat Rev Drug Discov, 2015 Dec 17; 15(3). PMID: 26669673 Free PMC article. Highly Cited. Review.
CCR 20th Anniversary Commentary: MAPK/ERK Pathway Inhibition in Melanoma-Kinase Inhibition Redux. Diwakar Davar, John M Kirkwood. Clin Cancer Res, 2015 Dec 17; 21(24). PMID: 26672083 Free PMC article.
New Strategies in Bladder Cancer: A Second Coming for Immunotherapy. Ali Ghasemzadeh, Trinity J Bivalacqua, Noah M Hahn, Charles G Drake. Clin Cancer Res, 2015 Dec 20; 22(4). PMID: 26683632 Free PMC article. Review.
Immune Checkpoint Blockade in Hepatocellular Carcinoma. M Kudo. Liver Cancer, 2016 Jan 07; 4(4). PMID: 26732472 Free PMC article.
Low-Intensity Focused Ultrasound Induces Reversal of Tumor-Induced T Cell Tolerance and Prevents Immune Escape. Sanmay Bandyopadhyay, Thomas J Quinn, +5 authors, Chandan Guha. less J Immunol, 2016 Jan 13; 196(4). PMID: 26755821 Free PMC article.
Large molecular systems landscape uncovers T cell trapping in human skin cancer. Reyk Hillert, Anne Gieseler, +5 authors, Walter Schubert. less Sci Rep, 2016 Jan 14; 6. PMID: 26757895 Free PMC article.
Cancer stem cells and immunoresistance: clinical implications and solutions. Jordi Codony-Servat, Rafael Rosell. Transl Lung Cancer Res, 2016 Jan 23; 4(6). PMID: 26798578 Free PMC article. Review.
Viro-immune therapy: A new strategy for treatment of pancreatic cancer. Andrea Marie Ibrahim, Yao-He Wang. World J Gastroenterol, 2016 Jan 27; 22(2). PMID: 26811622 Free PMC article. Review.
Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma. Hae Yong Yoo, Pora Kim, +9 authors, Sanghyuk Lee. less Haematologica, 2016 Jan 29; 101(6). PMID: 26819049 Free PMC article.
Predicting analysis times in randomized clinical trials with cancer immunotherapy. Tai-Tsang Chen. BMC Med Res Methodol, 2016 Feb 03; 16. PMID: 26830911 Free PMC article.
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too? Joseph M Ryan, Jeffrey S Wasser, Adam J Adler, Anthony T Vella. Expert Opin Biol Ther, 2016 Feb 09; 16(5). PMID: 26855028 Free PMC article. Review.
Combination Therapies for Melanoma: A New Standard of Care? Keiran S M Smalley, Zeynep Eroglu, Vernon K Sondak. Am J Clin Dermatol, 2016 Feb 11; 17(2). PMID: 26860106 Free PMC article. Review.
The Lymphatic System in Disease Processes and Cancer Progression. Timothy P Padera, Eelco F J Meijer, Lance L Munn. Annu Rev Biomed Eng, 2016 Feb 13; 18. PMID: 26863922 Free PMC article. Review.
Basics of PD-1 in self-tolerance, infection, and cancer immunity. Shunsuke Chikuma. Int J Clin Oncol, 2016 Feb 13; 21(3). PMID: 26864303 Review.
Predictive and Prognostic Role of Tumor-Infiltrating Lymphocytes for Early Breast Cancer According to Disease Subtypes: Sensitivity Analysis of Randomized Trials in Adjuvant and Neoadjuvant Setting. Luisa Carbognin, Sara Pilotto, +6 authors, Giampaolo Tortora. less Oncologist, 2016 Feb 13; 21(3). PMID: 26865589 Free PMC article.
Immune-based Therapy Clinical Trials in Hepatocellular Carcinoma. Dai Liu, Kevin F Staveley-O'Carroll, Guangfu Li. J Clin Cell Immunol, 2016 Feb 16; 6(6). PMID: 26877890 Free PMC article.
Immunotherapy for Gastric Cancer: A Focus on Immune Checkpoints. Maria Alsina, Markus Moehler, +2 authors, Cinta Hierro, Raquel Guardeño, Josep Tabernero. less Target Oncol, 2016 Feb 18; 11(4). PMID: 26880697 Review.
Ipilimumab (Anti-Ctla-4 Mab) in the treatment of metastatic melanoma: Effectiveness and toxicity management. Paola Savoia, Chiara Astrua, Paolo Fava. Hum Vaccin Immunother, 2016 Feb 19; 12(5). PMID: 26889818 Free PMC article. Review.
Evaluation of Costimulatory Molecules in Peripheral Blood Lymphocytes of Canine Patients with Histiocytic Sarcoma. Michihito Tagawa, Naoya Maekawa, Satoru Konnai, Satoshi Takagi. PLoS One, 2016 Feb 24; 11(2). PMID: 26901565 Free PMC article.
Cutting Edge: Engineering Active IKKβ in T Cells Drives Tumor Rejection. César Evaristo, Stefani Spranger, +5 authors, Maria-Luisa Alegre. less J Immunol, 2016 Feb 24; 196(7). PMID: 26903482 Free PMC article.
The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer. Jeffrey P Ward, Matthew M Gubin, Robert D Schreiber. Adv Immunol, 2016 Mar 01; 130. PMID: 26922999 Free PMC article. Highly Cited. Review.
Blocking immune checkpoints in prostate, kidney, and urothelial cancer: An overview. Angela K B Alme, Beerinder S Karir, Bishoy M Faltas, Charles G Drake. Urol Oncol, 2016 Mar 01; 34(4). PMID: 26923782 Free PMC article. Review.
Development of immuno-oncology drugs - from CTLA4 to PD1 to the next generations. Axel Hoos. Nat Rev Drug Discov, 2016 Mar 12; 15(4). PMID: 26965203 Highly Cited.
Combining Epigenetic and Immunotherapy to Combat Cancer. Katherine B Chiappinelli, Cynthia A Zahnow, Nita Ahuja, Stephen B Baylin. Cancer Res, 2016 Mar 19; 76(7). PMID: 26988985 Free PMC article. Highly Cited. Review.
Tremelimumab: research and clinical development. Begoña Comin-Anduix, Helena Escuin-Ordinas, Francisco Javier Ibarrondo. Onco Targets Ther, 2016 Apr 05; 9. PMID: 27042127 Free PMC article. Review.
The role of neoantigens in response to immune checkpoint blockade. Nadeem Riaz, Luc Morris, +3 authors, Timothy A Chan. less Int Immunol, 2016 Apr 07; 28(8). PMID: 27048318 Free PMC article. Review.
Manipulating TLR Signaling Increases the Anti-tumor T Cell Response Induced by Viral Cancer Therapies. Juan J Rojas, Padma Sampath, +4 authors, Steve H Thorne. less Cell Rep, 2016 Apr 07; 15(2). PMID: 27050526 Free PMC article.
Immunotherapy for cancer in the central nervous system: Current and future directions. David C Binder, Andrew A Davis, Derek A Wainwright. Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057463 Free PMC article. Highly Cited. Review.
Cocktails for cancer with a measure of immunotherapy. Heidi Ledford. Nature, 2016 Apr 15; 532(7598). PMID: 27075078
Emerging Opportunities and Challenges in Cancer Immunotherapy. Theresa L Whiteside, Sandra Demaria, +2 authors, Ignacio Melero. less Clin Cancer Res, 2016 Apr 17; 22(8). PMID: 27084738 Free PMC article. Highly Cited. Review.
Immune Checkpoint Therapy and the Search for Predictive Biomarkers. Padmanee Sharma. Cancer J, 2016 Apr 26; 22(2). PMID: 27111900 Free PMC article. Review.
Immune Checkpoint Therapies in Prostate Cancer. Sangeeta Goswami, Ana Aparicio, Sumit K Subudhi. Cancer J, 2016 Apr 26; 22(2). PMID: 27111907 Free PMC article. Review.
Potentiation of immunomodulatory antibody therapy with oncolytic viruses for treatment of cancer. Dmitriy Zamarin, Jedd D Wolchok. Mol Ther Oncolytics, 2014 Jan 01; 1. PMID: 27119094 Free PMC article. Review.
Radiation therapy and the abscopal effect: a concept comes of age. John Ng, Tong Dai. Ann Transl Med, 2016 Apr 30; 4(6). PMID: 27127771 Free PMC article.
Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination. Celine Boutros, Ahmad Tarhini, +14 authors, Caroline Robert. less Nat Rev Clin Oncol, 2016 May 05; 13(8). PMID: 27141885 Highly Cited. Review.
Cancer immunotherapy: the beginning of the end of cancer? Sofia Farkona, Eleftherios P Diamandis, Ivan M Blasutig. BMC Med, 2016 May 07; 14. PMID: 27151159 Free PMC article. Highly Cited. Review.
Bilateral neuroretinitis and anterior uveitis following ipilimumab treatment for metastatic melanoma. Laura Hahn, Kathryn L Pepple. J Ophthalmic Inflamm Infect, 2016 May 12; 6(1). PMID: 27165193 Free PMC article.
Targeting immune checkpoints in unresectable metastatic cutaneous melanoma: a systematic review and meta-analysis of anti-CTLA-4 and anti-PD-1 agents trials. Seongseok Yun, Nicole D Vincelette, +2 authors, Ivo Abraham. less Cancer Med, 2016 May 12; 5(7). PMID: 27167347 Free PMC article. Systematic Review.
PD-1 marks dysfunctional regulatory T cells in malignant gliomas. Daniel E Lowther, Brittany A Goods, +10 authors, David A Hafler. less JCI Insight, 2016 May 18; 1(5). PMID: 27182555 Free PMC article. Highly Cited.
Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity. Luke S Manlove, Jason M Schenkel, +4 authors, Michael A Farrar. less J Immunol, 2016 May 18; 196(11). PMID: 27183622 Free PMC article.
Checkpoint Inhibitors and Other Immune Therapies for Hodgkin and Non-Hodgkin Lymphoma. Eri Matsuki, Anas Younes. Curr Treat Options Oncol, 2016 May 20; 17(6). PMID: 27193488 Free PMC article. Review.
Burden of Nonsynonymous Mutations among TCGA Cancers and Candidate Immune Checkpoint Inhibitor Responses. Leandro M Colli, Mitchell J Machiela, +3 authors, Timothy A Myers, Lea Jessop, Kai Yu, Stephen J Chanock. less Cancer Res, 2016 May 20; 76(13). PMID: 27197178 Free PMC article. Highly Cited.
The oncolytic virus ΔPK has multimodal anti-tumor activity. Laure Aurelian, Dominique Bollino, Aric Colunga. Pathog Dis, 2016 Jun 01; 74(5). PMID: 27242376 Free PMC article. Review.
Revisiting of cancer vaccine?-Specific immunotherapy comes to field with the biomarker. Yuki Owada, Satoshi Muto, +2 authors, Takeo Hasegawa, Mitsunori Higuchi, Hiroyuki Suzuki. less Ann Transl Med, 2016 Jun 09; 4(9). PMID: 27275492 Free PMC article.
Checkpoint inhibitors and other novel immunotherapies for advanced renal cell carcinoma. Maria I Carlo, Martin H Voss, Robert J Motzer. Nat Rev Urol, 2016 Jun 22; 13(7). PMID: 27324121 Free PMC article. Review.
Immune checkpoint blockade therapy for bladder cancer treatment. Jayoung Kim. Investig Clin Urol, 2016 Jun 22; 57 Suppl 1. PMID: 27326412 Free PMC article. Review.
Association between the cytotoxic T-lymphocyte antigen 4-318C/T polymorphism and malignant tumor risk. Taiming Li, Chengdi Wang, +4 authors, Min Liu. less Biomed Rep, 2016 Jun 28; 5(1). PMID: 27347411 Free PMC article.
Immune checkpoint inhibitor combinations in solid tumors: opportunities and challenges. Chrisann Kyi, Michael A Postow. Immunotherapy, 2016 Jun 29; 8(7). PMID: 27349981 Free PMC article. Highly Cited. Review.
Molecular Profile of Tumor-Specific CD8+ T Cell Hypofunction in a Transplantable Murine Cancer Model. Katherine A Waugh, Sonia M Leach, +3 authors, Jill E Slansky. less J Immunol, 2016 Jul 03; 197(4). PMID: 27371726 Free PMC article.
Oncolytic Virus-Mediated Targeting of PGE2 in the Tumor Alters the Immune Status and Sensitizes Established and Resistant Tumors to Immunotherapy. Weizhou Hou, Padma Sampath, Juan J Rojas, Steve H Thorne. Cancer Cell, 2016 Jul 05; 30(1). PMID: 27374223 Free PMC article.
A phase I study of intratumoral ipilimumab and interleukin-2 in patients with advanced melanoma. Abhijit Ray, Matthew A Williams, +12 authors, Hung T Khong. less Oncotarget, 2016 Jul 09; 7(39). PMID: 27391442 Free PMC article.
A Perspective of Immunotherapy for Prostate Cancer. Ida Silvestri, Susanna Cattarino, +3 authors, Alessandro Sciarra. less Cancers (Basel), 2016 Jul 12; 8(7). PMID: 27399780 Free PMC article. Review.
Metastatic melanoma and immunotherapy. Benjamin Herzberg, David E Fisher. Clin Immunol, 2016 Jul 20; 172. PMID: 27430520 Free PMC article. Review.
A Mini-Review for Cancer Immunotherapy: Molecular Understanding of PD-1/PD-L1 Pathway & Translational Blockade of Immune Checkpoints. Yongshu Li, Fangfei Li, +4 authors, Ge Zhang. less Int J Mol Sci, 2016 Jul 22; 17(7). PMID: 27438833 Free PMC article. Highly Cited. Review.
Stereotactic Ablative Radiation Therapy Combined With Immunotherapy for Solid Tumors. Eric D Brooks, Jonathan E Schoenhals, +4 authors, James W Welsh. less Cancer J, 2016 Jul 22; 22(4). PMID: 27441745 Free PMC article. Review.
Magneto-nanosensor platform for probing low-affinity protein-protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction. Jung-Rok Lee, Daniel J B Bechstein, +5 authors, Shan X Wang. less Nat Commun, 2016 Jul 23; 7. PMID: 27447090 Free PMC article.
Releasing the brakes to fight cancer: The recent discovery of checkpoints has boosted the field of cancer immunotherapy. Katrin Weigmann. EMBO Rep, 2016 Jul 28; 17(9). PMID: 27458238 Free PMC article. Review.
CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma. Guang-Tao Yu, Lin-Lin Bu, +5 authors, Zhi-Jun Sun. less Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471622 Free PMC article.
Role of IL-2 in cancer immunotherapy. Tao Jiang, Caicun Zhou, Shengxiang Ren. Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471638 Free PMC article. Highly Cited. Review.
CD28 co-stimulation in T-cell homeostasis: a recent perspective. Niklas Beyersdorf, Thomas Kerkau, Thomas Hünig. Immunotargets Ther, 2015 Jan 01; 4. PMID: 27471717 Free PMC article. Review.
Oncogenes: The Passport for Viral Oncolysis Through PKR Inhibition. Janaina Fernandes. Biomark Cancer, 2016 Aug 04; 8. PMID: 27486347 Free PMC article. Review.
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy. Lewis Zhichang Shi, Tihui Fu, +7 authors, Padmanee Sharma. less Nat Commun, 2016 Aug 09; 7. PMID: 27498556 Free PMC article.
Novel therapeutic strategies in human malignancy: combining immunotherapy and oncolytic virotherapy. Padma Sampath, Steve H Thorne. Oncolytic Virother, 2015 Jan 01; 4. PMID: 27512672 Free PMC article. Review.
Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer. Benjamin Herzberg, Meghan J Campo, Justin F Gainor. Oncologist, 2016 Aug 19; 22(1). PMID: 27534574 Free PMC article. Review.
Harnessing the immune system to improve cancer therapy. Nikos E Papaioannou, Ourania V Beniata, +2 authors, Pinelopi Samara. less Ann Transl Med, 2016 Aug 27; 4(14). PMID: 27563648 Free PMC article. Highly Cited. Review.
Immune checkpoint inhibitors: the new frontier in non-small-cell lung cancer treatment. Hazem El-Osta, Kamran Shahid, Glenn M Mills, Prakash Peddi. Onco Targets Ther, 2016 Aug 31; 9. PMID: 27574451 Free PMC article. Review.
Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy. David B Page, Jianda Yuan, +22 authors, Heather L McArthur. less Cancer Immunol Res, 2016 Sep 03; 4(10). PMID: 27587469 Free PMC article.
Specific CD8(+) T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis. Elia Moreno-Cubero, Juan-Ramón Larrubia. World J Gastroenterol, 2016 Sep 09; 22(28). PMID: 27605882 Free PMC article. Review.
NLRC4 suppresses melanoma tumor progression independently of inflammasome activation. Ann M Janowski, Oscar R Colegio, +7 authors, Fayyaz S Sutterwala. less J Clin Invest, 2016 Sep 13; 126(10). PMID: 27617861 Free PMC article.
Ipilimumab reshapes T cell memory subsets in melanoma patients with clinical response. Joana Felix, Jérome Lambert, +13 authors, Hélène Moins-Teisserenc. less Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622012 Free PMC article.
Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy. Geoffrey S Williams, Bina Mistry, +20 authors, Robert W Wilkinson. less Oncotarget, 2016 Sep 15; 7(42). PMID: 27626702 Free PMC article.
T-Cell-Based Immunotherapy for Osteosarcoma: Challenges and Opportunities. Zhan Wang, Binghao Li, Yingqing Ren, Zhaoming Ye. Front Immunol, 2016 Sep 30; 7. PMID: 27683579 Free PMC article. Review.
Trends and advances in tumor immunology and lung cancer immunotherapy. Mohanad Aldarouish, Cailian Wang. J Exp Clin Cancer Res, 2016 Oct 01; 35(1). PMID: 27686848 Free PMC article. Review.
Mouse models in oncoimmunology. Laurence Zitvogel, Jonathan M Pitt, +2 authors, Romain Daillère, Mark J Smyth, Guido Kroemer. less Nat Rev Cancer, 2016 Nov 04; 16(12). PMID: 27687979 Highly Cited. Review.
Genomic Approaches to Understanding Response and Resistance to Immunotherapy. David A Braun, Kelly P Burke, Eliezer M Van Allen. Clin Cancer Res, 2016 Oct 05; 22(23). PMID: 27698000 Free PMC article. Review.
Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment. Yang Liu, Srilakshmi Pandeswara, +6 authors, Tyler J Curiel. less Cancer Res, 2016 Oct 16; 77(2). PMID: 27737881 Free PMC article.
Combining Radiation Therapy with Immune Checkpoint Blockade for Central Nervous System Malignancies. Neil M D'Souza, Penny Fang, +3 authors, Jing Li. less Front Oncol, 2016 Oct 25; 6. PMID: 27774435 Free PMC article. Review.
Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. Hanna Starobinets, Jordan Ye, +6 authors, Jayanta Debnath. less J Clin Invest, 2016 Oct 25; 126(12). PMID: 27775547 Free PMC article.
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway. Vassiliki A Boussiotis. N Engl J Med, 2016 Nov 03; 375(18). PMID: 27806234 Free PMC article. Highly Cited. Review.
A Journey in Science: "Not Lost in Translation". Tak Mak. Mol Med, 2016 Nov 08; 22. PMID: 27819109 Free PMC article.
Cell-Intrinsic Barriers of T Cell-Based Immunotherapy. Hazem E Ghoneim, Anthony E Zamora, Paul G Thomas, Ben A Youngblood. Trends Mol Med, 2016 Nov 09; 22(12). PMID: 27825667 Free PMC article. Review.
Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeting nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme. Szu-Ting Chou, Rameshwar Patil, +14 authors, Julia Y Ljubimova. less J Control Release, 2016 Nov 09; 244(Pt A). PMID: 27825958 Free PMC article.
Combinatorial immunotherapy for melanoma. D D George, V A Armenio, S C Katz. Cancer Gene Ther, 2016 Nov 12; 24(3). PMID: 27834353 Review.
Emerging role of immunotherapy in urothelial carcinoma-Immunobiology/biomarkers. Randy F Sweis, Matthew D Galsky. Urol Oncol, 2016 Nov 12; 34(12). PMID: 27836246 Free PMC article. Review.
Checkpoint Proteins in Pediatric Brain and Extracranial Solid Tumors: Opportunities for Immunotherapy. Eric K Ring, James M Markert, G Yancey Gillespie, Gregory K Friedman. Clin Cancer Res, 2016 Nov 12; 23(2). PMID: 27836863 Free PMC article. Review.
Ipilimumab: from preclinical development to future clinical perspectives in melanoma. Paul Letendre, Varun Monga, Mohammed Milhem, Yousef Zakharia. Future Oncol, 2016 Nov 25; 13(7). PMID: 27882779 Free PMC article. Review.
Combined VEGFR and CTLA-4 blockade increases the antigen-presenting function of intratumoral DCs and reduces the suppressive capacity of intratumoral MDSCs. Stephanie Du Four, Sarah K Maenhout, +3 authors, Joeri L Aerts. less Am J Cancer Res, 2016 Dec 03; 6(11). PMID: 27904768 Free PMC article.
Immunotherapy of head and neck cancer: Emerging clinical trials from a National Cancer Institute Head and Neck Cancer Steering Committee Planning Meeting. Julie E Bauman, Ezra Cohen, +17 authors, Shakun Malik. less Cancer, 2016 Dec 03; 123(7). PMID: 27906454 Free PMC article.
Gene expression profiling of anti-CTLA4-treated metastatic melanoma in patients with treatment-induced autoimmunity. Scott C Bresler, Le Min, +6 authors, Christine G Lian. less Lab Invest, 2016 Dec 06; 97(2). PMID: 27918555
Immune checkpoint therapy for pancreatic cancer. Henrik Johansson, Roland Andersson, +3 authors, Daniel Ansari. less World J Gastroenterol, 2016 Dec 07; 22(43). PMID: 27920468 Free PMC article. Review.
Phase I study of Nivolumab, an anti-PD-1 antibody, in patients with malignant solid tumors. Noboru Yamamoto, Hiroshi Nokihara, +7 authors, Tomohide Tamura. less Invest New Drugs, 2016 Dec 09; 35(2). PMID: 27928714 Free PMC article.
Molecular Pathways: The Necrosome-A Target for Cancer Therapy. Lena Seifert, George Miller. Clin Cancer Res, 2016 Dec 10; 23(5). PMID: 27932417 Free PMC article. Review.
Potent CD4+ T cell-associated antitumor memory responses induced by trifunctional bispecific antibodies in combination with immune checkpoint inhibition. Nina Deppisch, Peter Ruf, +2 authors, Nina Eißler, Horst Lindhofer, Ralph Mocikat. less Oncotarget, 2016 Dec 15; 8(3). PMID: 27966460 Free PMC article.
Immune Checkpoint Blockade in Hepatocellular Carcinoma: 2017 Update. M Kudo. Liver Cancer, 2016 Dec 21; 6(1). PMID: 27995082 Free PMC article.
Cytokines and metabolic factors regulate tumoricidal T-cell function during cancer immunotherapy. Adam J Adler, Payal Mittal, +3 authors, Anthony T Vella. less Immunotherapy, 2016 Dec 22; 9(1). PMID: 28000531 Free PMC article. Review.
Genetically engineered mouse models in oncology research and cancer medicine. Kelly Kersten, Karin E de Visser, Martine H van Miltenburg, Jos Jonkers. EMBO Mol Med, 2016 Dec 29; 9(2). PMID: 28028012 Free PMC article. Highly Cited. Review.
A New VISTA on combination therapy for negative checkpoint regulator blockade. Jie Deng, Isabelle Le Mercier, Anna Kuta, Randolph J Noelle. J Immunother Cancer, 2016 Dec 30; 4. PMID: 28031817 Free PMC article. Review.
A current perspective on cancer immune therapy: step-by-step approach to constructing the magic bullet. Gabriele D'Errico, Heather L Machado, Bruno Sainz. Clin Transl Med, 2017 Jan 05; 6(1). PMID: 28050779 Free PMC article. Review.
A special issue on cancer immunotherapy. Rong-Fu Wang. Cell Res, 2017 Jan 07; 27(1). PMID: 28057935 Free PMC article.
Immunotherapy: incorporation in the evolving paradigm of renal cancer management and future prospects. Kenneth G Liu, Sorab Gupta, Sanjay Goel. Oncotarget, 2017 Jan 07; 8(10). PMID: 28061473 Free PMC article. Review.
New Immunotherapy Strategies in Breast Cancer. Lin-Yu Yu, Jie Tang, +4 authors, Xiao-Ping Chen. less Int J Environ Res Public Health, 2017 Jan 14; 14(1). PMID: 28085094 Free PMC article. Review.
Immune-Checkpoint Inhibitors in the Era of Precision Medicine: What Radiologists Should Know. Marta Braschi-Amirfarzan, Sree Harsha Tirumani, Frank Stephen Hodi, Mizuki Nishino. Korean J Radiol, 2017 Jan 18; 18(1). PMID: 28096717 Free PMC article. Review.
CTLA-4 polymorphisms associate with breast cancer susceptibility in Asians: a meta-analysis. Zhiming Dai, Tian Tian, +9 authors, Zhijun Dai. less PeerJ, 2017 Jan 18; 5. PMID: 28097051 Free PMC article.
Is the Genetic Background of Co-Stimulatory CD28/CTLA-4 Pathway the Risk Factor for Prostate Cancer? Lidia Karabon, K Tupikowski, +7 authors, I Frydecka. less Pathol Oncol Res, 2017 Jan 20; 23(4). PMID: 28101800
Elements of cancer immunity and the cancer-immune set point. Daniel S Chen, Ira Mellman. Nature, 2017 Jan 20; 541(7637). PMID: 28102259 Highly Cited. Review.
New Combination Strategies Using Programmed Cell Death 1/Programmed Cell Death Ligand 1 Checkpoint Inhibitors as a Backbone. Siwen Hu-Lieskovan, Antoni Ribas. Cancer J, 2017 Jan 24; 23(1). PMID: 28114250 Free PMC article. Review.
PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective. Jun Wang, Ruirong Yuan, +3 authors, Wenru Song, Jingwei Sun, Delong Liu, Zihai Li. less J Hematol Oncol, 2017 Jan 27; 10(1). PMID: 28122590 Free PMC article. Highly Cited. Review.
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy. Padmanee Sharma, Siwen Hu-Lieskovan, Jennifer A Wargo, Antoni Ribas. Cell, 2017 Feb 12; 168(4). PMID: 28187290 Free PMC article. Highly Cited. Review.
Emerging role of checkpoint blockade therapy in lymphoma. Natalie Galanina, Justin Kline, Michael R Bishop. Ther Adv Hematol, 2017 Feb 17; 8(2). PMID: 28203344 Free PMC article. Review.
The prognostic value of cytotoxic T-lymphocyte antigen 4 in cancers: a systematic review and meta-analysis. Pingping Hu, Qiqi Liu, +4 authors, Jiandong Zhang. less Sci Rep, 2017 Feb 18; 7. PMID: 28211499 Free PMC article. Systematic Review.
Cardiovascular Toxicities Associated with Cancer Immunotherapies. Daniel Y Wang, Gosife Donald Okoye, +2 authors, Thomas G Neilan, Douglas B Johnson, Javid J Moslehi. less Curr Cardiol Rep, 2017 Feb 22; 19(3). PMID: 28220466 Highly Cited. Review.
Immune Checkpoint Blockade Biology in Mouse Models of Glioblastoma. Alan T Yeo, Alain Charest. J Cell Biochem, 2017 Feb 24; 118(9). PMID: 28230277 Free PMC article. Review.
[18F]Fluorodeoxyglucose Positron Emission Tomography Reveals a Complete Remission of Refractory Metastatic Melanoma after Therapy with Ipilimumab. Anna Yordanova, Carl Schlenkhoff, +2 authors, Holger Palmedo, Markus Essler, Hojjat Ahmadzadehfar. less Indian J Nucl Med, 2017 Mar 01; 32(1). PMID: 28242993 Free PMC article.
The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors. Andrew S Luksik, Russell Maxwell, Tomas Garzon-Muvdi, Michael Lim. Neurotherapeutics, 2017 Mar 05; 14(4). PMID: 28258545 Free PMC article. Review.
Introduction to checkpoint inhibitors and cancer immunotherapy. Arlene H Sharpe. Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258698 Free PMC article.
Immunotherapy in pancreatic cancer treatment: a new frontier. Komal Thind, Leslie J Padrnos, Ramesh K Ramanathan, Mitesh J Borad. Therap Adv Gastroenterol, 2017 Mar 14; 10(1). PMID: 28286568 Free PMC article. Review.
Immune checkpoint inhibition and its relationship with hypermutation phenoytype as a potential treatment for Glioblastoma. Manohan Sinnadurai, Kerrie L McDonald. J Neurooncol, 2017 Mar 16; 132(3). PMID: 28293764 Review.
Current modalities in cancer immunotherapy: Immunomodulatory antibodies, CARs and vaccines. Jason Lohmueller, Olivera J Finn. Pharmacol Ther, 2017 Mar 23; 178. PMID: 28322974 Free PMC article. Review.
Mechanistic and pharmacologic insights on immune checkpoint inhibitors. Randy F Sweis, Jason J Luke. Pharmacol Res, 2017 Mar 23; 120. PMID: 28323141 Free PMC article. Review.
Biological mechanisms of immune escape and implications for immunotherapy in head and neck squamous cell carcinoma. Jennifer D Moy, Jessica M Moskovitz, Robert L Ferris. Eur J Cancer, 2017 Mar 23; 76. PMID: 28324750 Free PMC article. Review.
Aptamers for CD Antigens: From Cell Profiling to Activity Modulation. Amin Nozari, Maxim V Berezovski. Mol Ther Nucleic Acids, 2017 Mar 23; 6. PMID: 28325295 Free PMC article. Review.
Interleukin-2 in Renal Cell Carcinoma: A Has-Been or a Still-Viable Option? Asim Amin, Richard L White. J Kidney Cancer VHL, 2014 Jan 01; 1(7). PMID: 28326252 Free PMC article.
IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients. Rossana Tallerico, Costanza M Cristiani, +21 authors, Ennio Carbone. less Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344869 Free PMC article.
Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure. Wafa Khamri, Robin D Abeles, +17 authors, Charalambos G Antoniades. less Gastroenterology, 2017 Apr 02; 153(1). PMID: 28363639 Free PMC article.
Targeted agents and immunotherapies: optimizing outcomes in melanoma. Jason J Luke, Keith T Flaherty, Antoni Ribas, Georgina V Long. Nat Rev Clin Oncol, 2017 Apr 05; 14(8). PMID: 28374786 Highly Cited. Review.
CD8 T-cell regulation by T regulatory cells and the programmed cell death protein 1 pathway. Pablo Penaloza-MacMaster. Immunology, 2017 Apr 05; 151(2). PMID: 28375543 Free PMC article. Review.
Cancer immunotherapies targeting the PD-1 signaling pathway. Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto, Tasuku Honjo. J Biomed Sci, 2017 Apr 06; 24(1). PMID: 28376884 Free PMC article. Highly Cited. Review.
Antigen Discovery and Therapeutic Targeting in Hematologic Malignancies. David A Braun, Catherine J Wu. Cancer J, 2017 Apr 15; 23(2). PMID: 28410299 Free PMC article. Review.
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden. Zachary R Chalmers, Caitlin F Connelly, +21 authors, Garrett M Frampton. less Genome Med, 2017 Apr 20; 9(1). PMID: 28420421 Free PMC article. Highly Cited.
Ipilimumab treatment decreases monocytic MDSCs and increases CD8 effector memory T cells in long-term survivors with advanced melanoma. Yago Pico de Coaña, Maria Wolodarski, +9 authors, Rolf Kiessling. less Oncotarget, 2017 Apr 21; 8(13). PMID: 28423487 Free PMC article.
Influence of ipilimumab on expanded tumour derived T cells from patients with metastatic melanoma. Jon Bjoern, Rikke Lyngaa, +4 authors, Inge Marie Svane. less Oncotarget, 2017 Apr 21; 8(16). PMID: 28423678 Free PMC article.
Checkpoint inhibitors in hematological malignancies. Chi Young Ok, Ken H Young. J Hematol Oncol, 2017 May 10; 10(1). PMID: 28482851 Free PMC article. Highly Cited. Review.
In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy. Sean P Arlauckas, Christopher S Garris, +9 authors, Mikael J Pittet. less Sci Transl Med, 2017 May 12; 9(389). PMID: 28490665 Free PMC article. Highly Cited.
Current status of chimeric antigen receptor engineered T cell-based and immune checkpoint blockade-based cancer immunotherapies. Upendra P Hegde, Bijay Mukherji. Cancer Immunol Immunother, 2017 May 13; 66(9). PMID: 28497159 Free PMC article. Review.
Mechanisms of Immune Tolerance in Leukemia and Lymphoma. Emily K Curran, James Godfrey, Justin Kline. Trends Immunol, 2017 May 18; 38(7). PMID: 28511816 Free PMC article. Review.
PD-1 targeted Immunotherapy as first-line therapy for advanced non-small-cell lung cancer patients. Arik Bernard Schulze, Lars Henning Schmidt. J Thorac Dis, 2017 May 20; 9(4). PMID: 28523184 Free PMC article.
Mini-review of conventional and hypofractionated radiation therapy combined with immunotherapy for non-small cell lung cancer. Allison M Campbell, Roy H Decker. Transl Lung Cancer Res, 2017 May 23; 6(2). PMID: 28529904 Free PMC article. Review.
Immune Checkpoint Inhibitor Therapy: What Line of Therapy and How to Choose? Chethan Ramamurthy, James L Godwin, Hossein Borghaei. Curr Treat Options Oncol, 2017 May 24; 18(6). PMID: 28534248 Review.
Cancer Vaccines in Ovarian Cancer: How Can We Improve? Silvia Martin Lluesma, Anita Wolfer, Alexandre Harari, Lana E Kandalaft. Biomedicines, 2017 May 26; 4(2). PMID: 28536377 Free PMC article. Review.
Interaction of molecular alterations with immune response in melanoma. Robert A Szczepaniak Sloane, Vancheswaran Gopalakrishnan, +3 authors, Jennifer A Wargo. less Cancer, 2017 May 26; 123(S11). PMID: 28543700 Free PMC article. Review.
Delivering safer immunotherapies for cancer. Lauren Milling, Yuan Zhang, Darrell J Irvine. Adv Drug Deliv Rev, 2017 May 27; 114. PMID: 28545888 Free PMC article. Highly Cited. Review.
Antibody-mediated neutralization of soluble MIC significantly enhances CTLA4 blockade therapy. Jingyu Zhang, Dai Liu, +4 authors, Jennifer D Wu. less Sci Adv, 2017 Jun 01; 3(5). PMID: 28560327 Free PMC article.
Genetically Engineered Vaccinia Viruses As Agents for Cancer Treatment, Imaging, and Transgene Delivery. Dana Haddad. Front Oncol, 2017 Jun 08; 7. PMID: 28589082 Free PMC article. Review.
QnAs with Tony Hunter and James Allison. Prashant Nair. Proc Natl Acad Sci U S A, 2017 Jun 21; 114(26). PMID: 28630309 Free PMC article.
CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation. Holger Lingel, Josef Wissing, +7 authors, Monika C Brunner-Weinzierl. less Cell Death Differ, 2017 Jun 24; 24(10). PMID: 28644433 Free PMC article.
Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity. Andrés Alloatti, Derek C Rookhuizen, +8 authors, Sebastian Amigorena. less J Exp Med, 2017 Jul 01; 214(8). PMID: 28663435 Free PMC article.
The emerging role of immune checkpoint based approaches in AML and MDS. Prajwal Boddu, Hagop Kantarjian, +3 authors, Naval Daver. less Leuk Lymphoma, 2017 Jul 07; 59(4). PMID: 28679300 Free PMC article. Review.
Genetic Mutations and Epigenetic Modifications: Driving Cancer and Informing Precision Medicine. Krysta Mila Coyle, Jeanette E Boudreau, Paola Marcato. Biomed Res Int, 2017 Jul 08; 2017. PMID: 28685150 Free PMC article. Review.
Targeted therapies for renal cell carcinoma. Edwin M Posadas, Suwicha Limvorasak, Robert A Figlin. Nat Rev Nephrol, 2017 Jul 12; 13(8). PMID: 28691713 Highly Cited. Review.
Developing Cures: Targeting Ontogenesis in Cancer. Victor T G Lin, Hawley C Pruitt, Rajeev S Samant, Lalita A Shevde. Trends Cancer, 2017 Jul 19; 3(2). PMID: 28718443 Free PMC article. Review.
Immunological tolerance as a barrier to protective HIV humoral immunity. Kristin Ms Schroeder, Amanda Agazio, Raul M Torres. Curr Opin Immunol, 2017 Jul 21; 47. PMID: 28728075 Free PMC article. Review.
CTLA4-CD28 chimera gene modification of T cells enhances the therapeutic efficacy of donor lymphocyte infusion for hematological malignancy. Hyung Bae Park, Ji Eun Lee, +3 authors, Kyungho Choi. less Exp Mol Med, 2017 Jul 29; 49(7). PMID: 28751785 Free PMC article.
Tools to define the melanoma-associated immunopeptidome. Eva Bräunlein, Angela M Krackhardt. Immunology, 2017 Jul 30; 152(4). PMID: 28755382 Free PMC article. Review.
Immunotherapy: Who Is Eligible? Daniel Wang, Jill Gilbert, Young J Kim. Otolaryngol Clin North Am, 2017 Aug 02; 50(4). PMID: 28755708 Free PMC article. Review.
Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer. Clemence Granier, Eleonore De Guillebon, +7 authors, Eric Tartour. less ESMO Open, 2017 Aug 02; 2(2). PMID: 28761757 Free PMC article. Highly Cited. Review.
Listening to each other: Infectious disease and cancer immunology. Russell E Vance, Michael J Eichberg, Daniel A Portnoy, David H Raulet. Sci Immunol, 2017 Aug 08; 2(7). PMID: 28783669 Free PMC article. Review.
Awakening immunity against cancer: a 2017 primer for clinicians. Amit Jain, Qing Zhang, Han-Chong Toh. Chin J Cancer, 2017 Aug 22; 36(1). PMID: 28823251 Free PMC article.
Cancer Immunotherapy: Historical Perspective of a Clinical Revolution and Emerging Preclinical Animal Models. William K Decker, Rodrigo F da Silva, +5 authors, Silke Paust. less Front Immunol, 2017 Aug 22; 8. PMID: 28824608 Free PMC article. Highly Cited. Review.
The 150 most important questions in cancer research and clinical oncology series: questions 50-56. Chinese Journal of Cancer. Chin J Cancer, 2017 Aug 30; 36(1). PMID: 28847311 Free PMC article.
Immune checkpoint inhibitors in cancer therapy. Eika S Webb, Peng Liu, +3 authors, Yao-He Wang. less J Biomed Res, 2017 Sep 04; 32(5). PMID: 28866656 Free PMC article.
PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome. Hashem O Alsaab, Samaresh Sau, +4 authors, Arun K Iyer. less Front Pharmacol, 2017 Sep 08; 8. PMID: 28878676 Free PMC article. Highly Cited. Review.
Immunotherapy of Lymphoma and Myeloma: Facts and Hopes. Matthew J Pianko, Alison J Moskowitz, Alexander M Lesokhin. Clin Cancer Res, 2017 Sep 14; 24(5). PMID: 28899972 Free PMC article. Review.
A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect. Bo-Tsang Huang, Wei-Yun Lai, +4 authors, Pan-Chyr Yang. less Mol Ther Nucleic Acids, 2017 Sep 18; 8. PMID: 28918052 Free PMC article.
Profile of pembrolizumab in the treatment of head and neck squamous cell carcinoma: design development and place in therapy. Sulsal Haque, Mahender Yellu, Jaskirat Randhawa, Nooshin Hashemi-Sadraei. Drug Des Devel Ther, 2017 Sep 19; 11. PMID: 28919706 Free PMC article. Review.
PD-L1 expression as poor prognostic factor in patients with non-squamous non-small cell lung cancer. Cuiling Zhou, Jianjun Tang, +10 authors, Haiqing Ma. less Oncotarget, 2017 Sep 25; 8(35). PMID: 28938570 Free PMC article.
Immunomodulatory Monoclonal Antibodies in Combined Immunotherapy Trials for Cutaneous Melanoma. Mariana Aris, José Mordoh, María Marcela Barrio. Front Immunol, 2017 Oct 04; 8. PMID: 28970830 Free PMC article. Review.
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis. Romualdo Barroso-Sousa, William T Barry, +4 authors, Sara M Tolaney. less JAMA Oncol, 2017 Oct 04; 4(2). PMID: 28973656 Free PMC article. Highly Cited. Systematic Review.
Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies. Mengnan He, Yan Chai, +6 authors, George F Gao. less Oncotarget, 2017 Oct 06; 8(40). PMID: 28978021 Free PMC article.
Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma. Maria-Carmela Speranza, Carmela Passaro, +18 authors, Sean E Lawler. less Neuro Oncol, 2017 Oct 11; 20(2). PMID: 29016938 Free PMC article.
Efficacy and Safety of Pembrolizumab in Patients Enrolled in KEYNOTE-030 in the United States: An Expanded Access Program. Tara C Gangadhar, Wen-Jen Hwu, +14 authors, April K S Salama. less J Immunother, 2017 Oct 14; 40(9). PMID: 29028788 Free PMC article.
CD4 and CD8 T lymphocyte interplay in controlling tumor growth. Dmitrij Ostroumov, Nora Fekete-Drimusz, +2 authors, Michael Saborowski, Florian Kühnel, Norman Woller. less Cell Mol Life Sci, 2017 Oct 17; 75(4). PMID: 29032503 Free PMC article. Review.
Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers. Chan-Young Ock, Jun-Eul Hwang, +12 authors, Ju-Seog Lee. less Nat Commun, 2017 Oct 21; 8(1). PMID: 29051489 Free PMC article.
Immune checkpoint inhibitors in renal cell carcinoma. Kirsty Ross, Rob J Jones. Clin Sci (Lond), 2017 Oct 29; 131(21). PMID: 29079639 Free PMC article. Review.
The association between CD28 gene rs3116496 polymorphism and breast cancer risk in Chinese women. Yuxiang Yan, Xianbo Zhang. Biosci Rep, 2017 Nov 02; 37(6). PMID: 29089469 Free PMC article.
Immune-Related Adverse Events Associated with Anti-PD-1/PD-L1 Treatment for Malignancies: A Meta-Analysis. Peng-Fei Wang, Yang Chen, +5 authors, Chang-Xiang Yan. less Front Pharmacol, 2017 Nov 03; 8. PMID: 29093678 Free PMC article. Highly Cited.
CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation. Jiehui Deng, Eric S Wang, +44 authors, Kwok-Kin Wong. less Cancer Discov, 2017 Nov 05; 8(2). PMID: 29101163 Free PMC article. Highly Cited.
Cardiotoxicity of immune checkpoint inhibitors. Gilda Varricchi, Maria Rosaria Galdiero, +5 authors, Carlo Gabriele Tocchetti. less ESMO Open, 2017 Nov 07; 2(4). PMID: 29104763 Free PMC article. Highly Cited. Review.
Imaging PD-L1 Expression with ImmunoPET. Charles Truillet, Hsueh Ling J Oh, +19 authors, Michael J Evans. less Bioconjug Chem, 2017 Nov 11; 29(1). PMID: 29125731 Free PMC article.
CD4+ T Cell Differentiation in Chronic Viral Infections: The Tfh Perspective. Laura A Vella, Ramin S Herati, E John Wherry. Trends Mol Med, 2017 Nov 16; 23(12). PMID: 29137933 Free PMC article. Review.
Immune checkpoint inhibitors: new strategies to checkmate cancer. R A M Wilson, T R J Evans, A R Fraser, R J B Nibbs. Clin Exp Immunol, 2017 Nov 16; 191(2). PMID: 29139554 Free PMC article. Review.
Mixed Signals: Co-Stimulation in Invariant Natural Killer T Cell-Mediated Cancer Immunotherapy. Susannah C Shissler, Michael S Lee, Tonya J Webb. Front Immunol, 2017 Nov 23; 8. PMID: 29163518 Free PMC article. Review.
Management of intracranial melanomas in the era of precision medicine. Grace J Young, Wenya Linda Bi, +3 authors, Ian F Dunn. less Oncotarget, 2017 Nov 29; 8(51). PMID: 29179523 Free PMC article. Review.
Development of a Diagnostic Programmed Cell Death 1-Ligand 1 Immunohistochemistry Assay for Nivolumab Therapy in Melanoma. Therese Phillips, Molly M Millett, +14 authors, Henrik Winther. less Appl Immunohistochem Mol Morphol, 2017 Dec 01; 26(1). PMID: 29189265 Free PMC article.
Next generation antibody drugs: pursuit of the 'high-hanging fruit'. Paul J Carter, Greg A Lazar. Nat Rev Drug Discov, 2017 Dec 02; 17(3). PMID: 29192287 Highly Cited. Review.
Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma. Arvind M Venkatesan, Rajesh Vyas, +12 authors, Craig J Ceol. less J Clin Invest, 2017 Dec 05; 128(1). PMID: 29202482 Free PMC article.
Soluble CD73 as biomarker in patients with metastatic melanoma patients treated with nivolumab. Silvana Morello, Mariaelena Capone, +6 authors, Paolo Antonio Ascierto. less J Transl Med, 2017 Dec 06; 15(1). PMID: 29202855 Free PMC article.
Antigen-specific oncolytic MV-based tumor vaccines through presentation of selected tumor-associated antigens on infected cells or virus-like particles. Stefan Hutzler, Stephanie Erbar, +9 authors, Michael D Mühlebach. less Sci Rep, 2017 Dec 06; 7(1). PMID: 29203786 Free PMC article.
Screening and antitumor effect of an anti‑CTLA‑4 nanobody. Ruirong Wan, Aiqun Liu, +9 authors, Xiaoling Lu. less Oncol Rep, 2017 Dec 06; 39(2). PMID: 29207143 Free PMC article.
Newly Emerging Immune Checkpoints: Promises for Future Cancer Therapy. Robert J Torphy, Richard D Schulick, Yuwen Zhu. Int J Mol Sci, 2017 Dec 07; 18(12). PMID: 29211042 Free PMC article. Review.
Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4. Bi Shi, Jianlin Geng, +9 authors, Hui Hu. less J Immunol, 2017 Dec 08; 200(2). PMID: 29212910 Free PMC article.
Immunotherapies for malignant glioma. Vassiliki A Boussiotis, Alain Charest. Oncogene, 2017 Dec 16; 37(9). PMID: 29242608 Free PMC article. Review.
Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy. Anne-Sophie Gautron, Alexandre Juillerat, +5 authors, Laurent Poirot. less Mol Ther Nucleic Acids, 2017 Dec 17; 9. PMID: 29246309 Free PMC article.
Ipilimumab plus Lenalidomide after Allogeneic and Autologous Stem Cell Transplantation for Patients with Lymphoid Malignancies. Issa F Khouri, Irina Fernandez Curbelo, +7 authors, Padmanee Sharma. less Clin Cancer Res, 2017 Dec 17; 24(5). PMID: 29246938 Free PMC article.
Novel immunotherapy approaches for metastatic urothelial and renal cell carcinoma. Zhiying Shao, Andrew Z Wang, Daniel J George, Tian Zhang. Asian J Urol, 2016 Oct 01; 3(4). PMID: 29264195 Free PMC article. Review.
How Checkpoint Inhibitors Are Changing the Treatment Paradigm in Solid Tumors: What Advanced Practitioners in Oncology Need to Know. Marianne Davies. J Adv Pract Oncol, 2016 Jul 01; 7(5). PMID: 29282426 Free PMC article. Review.
Cancer Immunotherapy and Personalized Medicine: Emerging Technologies and Biomarker-Based Approaches. Laura Maciejko, Munisha Smalley, Aaron Goldman. J Mol Biomark Diagn, 2017 Dec 30; 8(5). PMID: 29285416 Free PMC article.
Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models. Katherine E Lewis, Mark J Selby, +11 authors, Stacey R Dillon. less Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296539 Free PMC article.
Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade. Jie Bai, Zhitao Gao, +3 authors, Xiang Li, Liang Dong, Weidong Han, Jing Nie. less Oncotarget, 2018 Jan 05; 8(66). PMID: 29299180 Free PMC article. Review.
Improving immune-vascular crosstalk for cancer immunotherapy. Yuhui Huang, Betty Y S Kim, +3 authors, Wen Jiang. less Nat Rev Immunol, 2018 Jan 16; 18(3). PMID: 29332937 Free PMC article. Highly Cited. Review.
LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. Masoud F Tavazoie, Ilana Pollack, +21 authors, Sohail F Tavazoie. less Cell, 2018 Jan 18; 172(4). PMID: 29336888 Free PMC article. Highly Cited.
Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade. Charlotte E Ariyan, Mary Sue Brady, +19 authors, James P Allison. less Cancer Immunol Res, 2018 Jan 18; 6(2). PMID: 29339377 Free PMC article.
Clinical Development of PD-1 in Advanced Melanoma. Rodrigo Ramella Munhoz, Michael Andrew Postow. Cancer J, 2018 Jan 24; 24(1). PMID: 29360722 Free PMC article. Review.
The biology and management of non-small cell lung cancer. Roy S Herbst, Daniel Morgensztern, Chris Boshoff. Nature, 2018 Jan 25; 553(7689). PMID: 29364287 Highly Cited. Review.
Network-based co-expression analysis for exploring the potential diagnostic biomarkers of metastatic melanoma. Li-Xin Wang, Yang Li, Guan-Zhi Chen. PLoS One, 2018 Jan 30; 13(1). PMID: 29377892 Free PMC article.
Expected Paradigm Shift in Brain Metastases Therapy-Immune Checkpoint Inhibitors. Vishal Jindal, Sorab Gupta. Mol Neurobiol, 2018 Feb 01; 55(8). PMID: 29383686 Review.
Neurological Adverse Events Associated with Immune Checkpoint Inhibitors: Diagnosis and Management. Christophoros Astaras, Rita de Micheli, +2 authors, Bianca Moura, Thomas Hundsberger, Andreas F Hottinger. less Curr Neurol Neurosci Rep, 2018 Feb 03; 18(1). PMID: 29392441 Review.
Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa. Kabir A Khan, Robert S Kerbel. Nat Rev Clin Oncol, 2018 Feb 13; 15(5). PMID: 29434333 Highly Cited. Review.
Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice. Xuexiang Du, Mingyue Liu, +8 authors, Pan Zheng. less Cell Res, 2018 Feb 22; 28(4). PMID: 29463898 Free PMC article. Highly Cited.
A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy. Xuexiang Du, Fei Tang, +14 authors, Yang Liu. less Cell Res, 2018 Feb 24; 28(4). PMID: 29472691 Free PMC article. Highly Cited.
Importance of immune monitoring approaches and the use of immune checkpoints for the treatment of diffuse intrinsic pontine glioma: From bench to clinic and vice versa (Review). Jorge Augusto Borin Scutti. Int J Oncol, 2018 Feb 28; 52(4). PMID: 29484440 Free PMC article. Review.
Immune Monitoring of Cancer Patients Prior to and During CTLA-4 or PD-1/PD-L1 Inhibitor Treatment. Antje Tunger, Maximilian Kießler, +4 authors, Marc Schmitz. less Biomedicines, 2018 Mar 02; 6(1). PMID: 29494517 Free PMC article. Review.
The Rationale and Emerging Use of Neoadjuvant Immune Checkpoint Blockade for Solid Malignancies. Emily Z Keung, Esosa U Ukponmwan, Alexandria P Cogdill, Jennifer A Wargo. Ann Surg Oncol, 2018 Mar 04; 25(7). PMID: 29500764 Free PMC article.
Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients. Priyanka B Subrahmanyam, Zhiwan Dong, +7 authors, F Stephen Hodi. less J Immunother Cancer, 2018 Mar 08; 6(1). PMID: 29510697 Free PMC article. Highly Cited.
The Modulatory Roles of N-glycans in T-Cell-Mediated Autoimmune Diseases. Ming-Wei Chien, Shin-Huei Fu, +2 authors, Chao-Yuan Hsu, Yu-Wen Liu, Huey-Kang Sytwu. less Int J Mol Sci, 2018 Mar 09; 19(3). PMID: 29518037 Free PMC article. Review.
Combination immunotherapies implementing adoptive T-cell transfer for advanced-stage melanoma. Kendra C Foley, Michael I Nishimura, Tamson V Moore. Melanoma Res, 2018 Mar 10; 28(3). PMID: 29521881 Free PMC article. Review.
Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer. Taylor T Chrisikos, Yifan Zhou, +3 authors, Haiyan S Li. less Mol Immunol, 2018 Mar 20; 110. PMID: 29549977 Free PMC article. Review.
Immunotherapy for Merkel cell carcinoma: a turning point in patient care. Isaac S Chan, Shailender Bhatia, Howard L Kaufman, Evan J Lipson. J Immunother Cancer, 2018 Mar 24; 6(1). PMID: 29566749 Free PMC article. Review.
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Frederick Arce Vargas, Andrew J S Furness, +32 authors, Sergio A Quezada. less Cancer Cell, 2018 Mar 27; 33(4). PMID: 29576375 Free PMC article. Highly Cited.
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies. Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok. Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946 Free PMC article. Highly Cited. Review.
Immunotherapy for Breast Cancer: Current and Future Strategies. Austin D Williams, Kyle K Payne, +4 authors, Julia Tchou. less Curr Surg Rep, 2018 Apr 17; 5. PMID: 29657904 Free PMC article.
TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy. Heng-Jia Liu, Patrick H Lizotte, +8 authors, Elizabeth P Henske. less JCI Insight, 2018 Apr 20; 3(8). PMID: 29669930 Free PMC article.
Integrative Pharmacology: Advancing Development of Effective Immunotherapies. Mohammad Tabrizi, Daping Zhang, Vaishnavi Ganti, Glareh Azadi. AAPS J, 2018 Apr 29; 20(4). PMID: 29704129 Review.
Immunotherapeutic interventions of Triple Negative Breast Cancer. Zehuan Li, Yiran Qiu, +2 authors, Weiqi Lu, Ying Jiang, Jin Wang. less J Transl Med, 2018 Jun 01; 16(1). PMID: 29848327 Free PMC article. Review.
Improved sensitivity for detection of breast cancer by combination of miR-34a and tumor markers CA 15-3 or CEA. Martin Zaleski, Makbule Kobilay, +7 authors, Stefan Holdenrieder. less Oncotarget, 2018 Jun 02; 9(32). PMID: 29854296 Free PMC article.
Tune Up In Situ Autovaccination against Solid Tumors with Oncolytic Viruses. Teresa Nguyen, Naze G Avci, +2 authors, Dong Ho Shin, Naiara Martinez-Velez, Hong Jiang. less Cancers (Basel), 2018 Jun 03; 10(6). PMID: 29857493 Free PMC article. Review.
Therapeutic Antibodies for Myeloid Neoplasms-Current Developments and Future Directions. Christian M Schürch. Front Oncol, 2018 Jun 06; 8. PMID: 29868474 Free PMC article. Review.
Immunotherapy in Breast Cancer: the New Frontier. Zishuo I Hu, Heather L McArthur. Curr Breast Cancer Rep, 2018 Jun 09; 10(2). PMID: 29881518 Free PMC article. Review.
Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. David Wang, Jason Quiros, +12 authors, Michel DuPage. less Cell Rep, 2018 Jun 14; 23(11). PMID: 29898397 Free PMC article. Highly Cited.
Tumor Regression and Cure Depends on Sustained Th1 Responses. Min Dai, Ingegerd Hellstrom, +2 authors, Yuen Y Yip, Hans Olov Sjögren, Karl Erik Hellstrom. less J Immunother, 2018 Jun 19; 41(8). PMID: 29912725 Free PMC article.
Pediatric Cancer Immunotherapy: Opportunities and Challenges. Mary Frances Wedekind, Nicholas L Denton, Chun-Yu Chen, Timothy P Cripe. Paediatr Drugs, 2018 Jun 28; 20(5). PMID: 29948928 Free PMC article. Review.
PD-L1, TIM-3, and CTLA-4 Blockade Fails To Promote Resistance to Secondary Infection with Virulent Strains of Toxoplasma gondii. Samantha D Splitt, Scott P Souza, +4 authors, Kirk D C Jensen. less Infect Immun, 2018 Jul 04; 86(9). PMID: 29967089 Free PMC article.
Cancer Immune Therapy: Prognostic Significance and Implications for Therapy of PD-1 in BCG-Relapsing Bladder Cancer. Neelam Mukherjee, Robert Svatek. Ann Surg Oncol, 2018 Jul 05; 25(9). PMID: 29971674 Free PMC article.
Cancer immune checkpoint blockade therapy and its associated autoimmune cardiotoxicity. Jiu-Cheng Zhang, Wei-Dong Chen, +6 authors, Hua Zhu. less Acta Pharmacol Sin, 2018 Jul 12; 39(11). PMID: 29991709 Free PMC article. Review.
Immunotherapy for pancreatic cancer: Barriers and breakthroughs. Robert J Torphy, Yuwen Zhu, Richard D Schulick. Ann Gastroenterol Surg, 2018 Jul 14; 2(4). PMID: 30003190 Free PMC article. Highly Cited. Review.
Microbial biomarkers for immune checkpoint blockade therapy against cancer. Keishi Adachi, Koji Tamada. J Gastroenterol, 2018 Jul 14; 53(9). PMID: 30003334 Free PMC article. Review.
Phytosomal curcumin causes natural killer cell-dependent repolarization of glioblastoma (GBM) tumor-associated microglia/macrophages and elimination of GBM and GBM stem cells. Sumit Mukherjee, Angela Fried, +4 authors, Probal Banerjee. less J Exp Clin Cancer Res, 2018 Jul 26; 37(1). PMID: 30041669 Free PMC article.
Pembrolizumab KEYNOTE-001: an adaptive study leading to accelerated approval for two indications and a companion diagnostic. S P Kang, K Gergich, +4 authors, E H Rubin. less Ann Oncol, 2018 Jul 28; 28(6). PMID: 30052728 Free PMC article.
Treg Fragility: A Prerequisite for Effective Antitumor Immunity? Abigail E Overacre-Delgoffe, Dario A A Vignali. Cancer Immunol Res, 2018 Aug 03; 6(8). PMID: 30068755 Free PMC article. Review.
Complex interplay between tumor microenvironment and cancer therapy. Minhong Shen, Yibin Kang. Front Med, 2018 Aug 12; 12(4). PMID: 30097962 Review.
Ipilimumab: A tale of twists and turns. Dhiraj Abhyankar. South Asian J Cancer, 2018 Aug 17; 7(3). PMID: 30112338 Free PMC article.
Ipilimumab in combination with nivolumab for the treatment of renal cell carcinoma. Xin Gao, David F McDermott. Expert Opin Biol Ther, 2018 Aug 21; 18(9). PMID: 30124333 Free PMC article. Review.
High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors. Jolanda Brummelman, Emilia M C Mazza, +10 authors, Enrico Lugli. less J Exp Med, 2018 Aug 30; 215(10). PMID: 30154266 Free PMC article. Highly Cited.
Insights Into the Molecular Mechanisms of T Follicular Helper-Mediated Immunity and Pathology. Lei Qin, Tayab C Waseem, +4 authors, Roza Nurieva. less Front Immunol, 2018 Aug 31; 9. PMID: 30158933 Free PMC article. Review.
Strategies for Predicting Response to Checkpoint Inhibitors. Roberta Zappasodi, Jedd D Wolchok, Taha Merghoub. Curr Hematol Malig Rep, 2018 Aug 31; 13(5). PMID: 30159703 Free PMC article. Review.
Neurologic immune-related adverse events associated with adjuvant ipilimumab: report of two cases. Christine A Garcia, Alex El-Ali, +4 authors, Diwakar Davar. less J Immunother Cancer, 2018 Sep 02; 6(1). PMID: 30170622 Free PMC article.
Precision medicine in pediatric oncology. Stefan E G Burdach, Mike-Andrew Westhoff, Maximilian Felix Steinhauser, Klaus-Michael Debatin. Mol Cell Pediatr, 2018 Sep 02; 5(1). PMID: 30171420 Free PMC article. Review.
Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints. Lee-Shing Chang, Romualdo Barroso-Sousa, +3 authors, Le Min. less Endocr Rev, 2018 Sep 06; 40(1). PMID: 30184160 Free PMC article. Review.
When to consider alternatives to front-line immune therapies in metastatic melanoma. Daniel Y Wang, Douglas B Johnson. Melanoma Manag, 2017 May 01; 4(2). PMID: 30190906 Free PMC article.
Utility of ipilimumab in melanoma patients who progress on anti-PD-1 therapy. Cesar E Ochoa, Richard W Joseph. Melanoma Manag, 2018 Sep 08; 4(3). PMID: 30190917 Free PMC article.
Stochastic modeling of tumor progression and immune evasion. Jason T George, Herbert Levine. J Theor Biol, 2018 Sep 16; 458. PMID: 30218648 Free PMC article.
Personal history of infections and immunotherapy: Unexpected links and possible therapeutic opportunities. Camille Jacqueline, Nathalie Bonnefoy, +2 authors, Benjamin Roche. less Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221066 Free PMC article. Review.
TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM. Alice L Hung, Russell Maxwell, +20 authors, Michael Lim. less Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221069 Free PMC article. Highly Cited.
Targeting PVR (CD155) and its receptors in anti-tumor therapy. Paola Kučan Brlić, Tihana Lenac Roviš, +3 authors, Stipan Jonjić. less Cell Mol Immunol, 2018 Oct 03; 16(1). PMID: 30275538 Free PMC article. Review.
The intracellular signalosome of PD-L1 in cancer cells. David Escors, María Gato-Cañas, +4 authors, Grazyna Kochan. less Signal Transduct Target Ther, 2018 Oct 03; 3. PMID: 30275987 Free PMC article. Highly Cited. Review.
Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy. Jinfang Zhang, Fabin Dang, Junming Ren, Wenyi Wei. Trends Biochem Sci, 2018 Oct 06; 43(12). PMID: 30287140 Free PMC article. Review.
Synthetic DNA-Encoded Monoclonal Antibody Delivery of Anti-CTLA-4 Antibodies Induces Tumor Shrinkage In Vivo. Elizabeth K Duperret, Aspen Trautz, +10 authors, David B Weiner. less Cancer Res, 2018 Oct 06; 78(22). PMID: 30287678 Free PMC article.
Safety of combined PD-1 pathway inhibition and radiation therapy for non-small-cell lung cancer: A multicentric retrospective study from the GFPC. Paul Lesueur, Alexandre Escande, +9 authors, Radj Gervais. less Cancer Med, 2018 Oct 13; 7(11). PMID: 30311424 Free PMC article.
Cancer immunotherapy in routine cost-effective cancer care? Sir Marc Feldmann. EMBO Mol Med, 2018 Oct 17; 10(11). PMID: 30322840 Free PMC article.
Immune-checkpoint inhibitors for combating T-cell dysfunction in cancer. Ewelina Grywalska, Marcin Pasiarski, Stanisław Góźdź, Jacek Roliński. Onco Targets Ther, 2018 Oct 17; 11. PMID: 30323625 Free PMC article. Review.
[Mode of action, new targets and potential biomarkers in modern immunotherapy]. J Bedke, V Stühler, T Todenhöfer, A Stenzl. Urologe A, 2018 Oct 24; 57(11). PMID: 30350128 Review.
Progress in Kidney Cancer Outcomes Through Collaboration, Innovation, and Discovery. David F McDermott, Michael Carducci. J Clin Oncol, 2018 Oct 30;. PMID: 30372393 Free PMC article.
Nobel committee honors tumor immunologists. Anand Rotte, Gabriella D'Orazi, Madhuri Bhandaru. J Exp Clin Cancer Res, 2018 Nov 01; 37(1). PMID: 30376854 Free PMC article.
Systemic Therapy for Hepatocellular Carcinoma: Latest Advances. Masatoshi Kudo. Cancers (Basel), 2018 Nov 02; 10(11). PMID: 30380773 Free PMC article. Highly Cited. Review.
Profiling Immune Escape in Hodgkin's and Diffuse large B-Cell Lymphomas Using the Transcriptome and Immunostaining. Sarah Péricart, Marie Tosolini, +10 authors, Camille Laurent. less Cancers (Basel), 2018 Nov 06; 10(11). PMID: 30384489 Free PMC article.
2018 Nobel Prize in physiology or medicine. Mark J Smyth, Michele Wl Teng. Clin Transl Immunology, 2018 Nov 06; 7(10). PMID: 30386598 Free PMC article.
An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion. John D Klement, Amy V Paschall, +7 authors, Kebin Liu. less J Clin Invest, 2018 Nov 06; 128(12). PMID: 30395540 Free PMC article.
The 2018 Nobel Prize in medicine goes to cancer immunotherapy (editorial for BMC cancer). Zong Sheng Guo. BMC Cancer, 2018 Nov 13; 18(1). PMID: 30415640 Free PMC article.
Transformation of Old Concepts for a New Era of Cancer Immunotherapy: Cytokine Therapy and Cancer Vaccines as Combination Partners of PD1/PD-L1 Inhibitors. Romualdo Barroso-Sousa, Patrick A Ott. Curr Oncol Rep, 2018 Dec 01; 21(1). PMID: 30498900 Review.
Long-Lived Plasma Cells in Mice and Men. Siggeir F Brynjolfsson, Linn Persson Berg, +4 authors, Ola Grimsholm. less Front Immunol, 2018 Dec 07; 9. PMID: 30505309 Free PMC article. Review.
PD-L1 expression with immune-infiltrate evaluation and outcome prediction in melanoma patients treated with ipilimumab. Gabriele Madonna, Carmen Ballesteros-Merino, +10 authors, Paolo A Ascierto. less Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524879 Free PMC article.
Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models. Vassilis Genoud, Eliana Marinari, +5 authors, Paul R Walker. less Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524896 Free PMC article.
Immunological targets for cancer therapy: new recognition. Michael R Shurin. Immunotargets Ther, 2018 Dec 13; 7. PMID: 30538966 Free PMC article.
CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy. Monika C Brunner-Weinzierl, Christopher E Rudd. Front Immunol, 2018 Dec 14; 9. PMID: 30542345 Free PMC article. Review.
Progresses and Perspectives of Anti-PD-1/PD-L1 Antibody Therapy in Head and Neck Cancers. Bo Yang, Tingjun Liu, +4 authors, Jianbo Sun. less Front Oncol, 2018 Dec 14; 8. PMID: 30547012 Free PMC article. Review.
Synthesis and Immunomodulatory Activity of Fluorine-Containing Bisphosphonates. Satoshi Mizuta, Mohammed S O Tagod, +5 authors, Yoshimasa Tanaka. less ChemMedChem, 2019 Jan 15; 14(4). PMID: 30637982 Free PMC article.
Determination of human γδ T cell-mediated cytotoxicity using a non-radioactive assay system. Mohammed S O Tagod, Satoshi Mizuta, +6 authors, Yoshimasa Tanaka. less J Immunol Methods, 2019 Jan 18; 466. PMID: 30654042 Free PMC article.
Nanotechnology and Immunotherapy in Ovarian Cancer: Tracing New Landscapes. Bruna Corradetti, Simone Pisano, Robert Steven Conlan, Mauro Ferrari. J Pharmacol Exp Ther, 2019 Feb 10; 370(3). PMID: 30737357 Free PMC article. Review.
Targeting immune cells for cancer therapy. Sin Yee Gun, Sharon Wei Ling Lee, Je Lin Sieow, Siew Cheng Wong. Redox Biol, 2019 Mar 29; 25. PMID: 30917934 Free PMC article. Highly Cited. Review.
Rheumatic complications in cancer patients treated with immune checkpoint inhibitors. Kyung-Ann Lee, Hae-Rim Kim, So Young Yoon. Korean J Intern Med, 2019 Apr 25; 34(6). PMID: 31014065 Free PMC article. Review.
Application of PD-1 Blockade in Cancer Immunotherapy. Xiaomo Wu, Zhongkai Gu, +4 authors, Xiaolong Liu. less Comput Struct Biotechnol J, 2019 Jun 18; 17. PMID: 31205619 Free PMC article. Highly Cited. Review.
pH-sensitive anti-CTLA4 antibodies: yes to efficacy, no to toxicity. Amnon Altman, Kok-Fai Kong. Cell Res, 2019 Jul 14; 29(8). PMID: 31300731 Free PMC article.
Immunotherapy for pediatric brain tumors: past and present. Jessica B Foster, Peter J Madsen, +6 authors, Angela J Waanders. less Neuro Oncol, 2019 Sep 11; 21(10). PMID: 31504801 Free PMC article. Review.
Cardiotoxicity from immune checkpoint inhibitors. Lars Michel, Tienush Rassaf, Matthias Totzeck. Int J Cardiol Heart Vasc, 2019 Sep 14; 25. PMID: 31517036 Free PMC article. Review.
Selective inhibition of low-affinity memory CD8+ T cells by corticosteroids. Akihiro Tokunaga, Daisuke Sugiyama, +7 authors, Hiroyoshi Nishikawa. less J Exp Med, 2019 Sep 21; 216(12). PMID: 31537643 Free PMC article.
Monoclonal Antibodies in Dermatooncology-State of the Art and Future Perspectives. Malgorzata Bobrowicz, Radoslaw Zagozdzon, +3 authors, Magdalena Winiarska. less Cancers (Basel), 2019 Sep 27; 11(10). PMID: 31554169 Free PMC article. Review.
Fucosylated α1-acid glycoprotein as a biomarker to predict prognosis following tumor immunotherapy of patients with lung cancer. Takehiko Yokobori, Shin Yazawa, +6 authors, Ken Shirabe. less Sci Rep, 2019 Oct 12; 9(1). PMID: 31601857 Free PMC article.
CTLA-4 Immunohistochemistry and Quantitative Image Analysis for Profiling of Human Cancers. Charles Brown, Farzad Sekhavati, +4 authors, Keith E Steele. less J Histochem Cytochem, 2019 Oct 15; 67(12). PMID: 31609157 Free PMC article.
Immunopathogenesis of Immune Checkpoint Inhibitor-Related Adverse Events: Roles of the Intestinal Microbiome and Th17 Cells. Ronald Anderson, Annette J Theron, Bernardo L Rapoport. Front Immunol, 2019 Oct 17; 10. PMID: 31616428 Free PMC article. Review.
Suppressing immunotherapy by organ-specific tumor microenvironments: what is in the brain? Chenyu Zhang, Dihua Yu. Cell Biosci, 2019 Oct 19; 9. PMID: 31624532 Free PMC article. Review.
Immune checkpoint inhibitors in mCRPC - rationales, challenges and perspectives. H Taghizadeh, M Marhold, +3 authors, E Tomasich, S Udovica, A Merchant, M Krainer. less Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646092 Free PMC article. Review.
Immunotherapy in HER2-positive breast cancer: state of the art and future perspectives. E Krasniqi, G Barchiesi, +17 authors, P Vici. less J Hematol Oncol, 2019 Oct 31; 12(1). PMID: 31665051 Free PMC article. Review.
Demystifying Cancer Immunotherapy for Lay Audiences. Kiara Ellis, Christopher A Pennell. Front Immunol, 2019 Nov 05; 10. PMID: 31681338 Free PMC article.
Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4. Shuang Qin, Linping Xu, +3 authors, Ming Yi, Shengnan Yu, Kongming Wu, Suxia Luo. less Mol Cancer, 2019 Nov 07; 18(1). PMID: 31690319 Free PMC article. Highly Cited. Review.
The First Year of HemaSphere and Many More to Come. Andreas Engert, Jan Cools. Hemasphere, 2019 Nov 15; 2(6). PMID: 31723799 Free PMC article.
Innovative oncology products: time to revisit the strategy development? Andriy Krendyukov. ESMO Open, 2019 Nov 22; 4(5). PMID: 31749992 Free PMC article.
Analysis of key clinical features for achieving complete remission in stage III and IV non-small cell lung cancer patients. Takuya Aoki, Takeshi Akiba, +21 authors, Koichiro Asano. less Respir Res, 2019 Nov 23; 20(1). PMID: 31752884 Free PMC article.
Cancer immune escape: MHC expression in primary tumours versus metastases. Federico Garrido, Natalia Aptsiauri. Immunology, 2019 Sep 12; 158(4). PMID: 31509607 Free PMC article. Review.
Neoantigens and genome instability: impact on immunogenomic phenotypes and immunotherapy response. Elaine R Mardis. Genome Med, 2019 Nov 22; 11(1). PMID: 31747945 Free PMC article. Review.
Setting the scene - a future 'epidemic' of immune-related adverse events in association with checkpoint inhibitor therapy. Maria V Bermudez, Sophie Papa. Rheumatology (Oxford), 2019 Dec 10; 58(Suppl 7). PMID: 31816083 Free PMC article. Review.
MicroRNA regulation of CD8+ T cell responses. John D Gagnon, K Mark Ansel. Noncoding RNA Investig, 2019 Dec 18; 3. PMID: 31844841 Free PMC article.
Natural Products and Synthetic Analogs as a Source of Antitumor Drugs. Javad Sharifi-Rad, Adem Ozleyen, +8 authors, William C Cho. less Biomolecules, 2019 Nov 07; 9(11). PMID: 31683894 Free PMC article. Review.
Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer. Katsiaryna Marhelava, Zofia Pilch, +2 authors, Radoslaw Zagozdzon. less Cancers (Basel), 2019 Nov 14; 11(11). PMID: 31717326 Free PMC article. Review.
Discovery of Small Molecules for the Reversal of T Cell Exhaustion. Brett S Marro, Jaroslav Zak, +3 authors, Michael B A Oldstone. less Cell Rep, 2019 Dec 05; 29(10). PMID: 31801090 Free PMC article.
The "Achilles' Heel" of Cancer and Its Implications for the Development of Novel Immunotherapeutic Strategies. Kroopa Joshi, Benjamin M Chain, Karl S Peggs, Sergio A Quezada. Cold Spring Harb Perspect Med, 2017 Jun 21; 8(1). PMID: 28630228 Free PMC article. Review.
Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy. Yan Zhang, Xuexiang Du, +9 authors, Yang Liu. less Cell Res, 2019 Jul 04; 29(8). PMID: 31267017 Free PMC article.
Immunotherapy for advanced melanoma. Lei Fang, Anke S Lonsdorf, Sam T Hwang. J Invest Dermatol, 2008 Oct 18; 128(11). PMID: 18927541 Free PMC article. Review.
T-Regulatory Cells In Tumor Progression And Therapy. Amit Verma, Rohit Mathur, +3 authors, Bilikere S Dwarakanath. less Cancer Manag Res, 2020 Jan 11; 11. PMID: 31920383 Free PMC article. Review.
The Intriguing History of Cancer Immunotherapy. Paula Dobosz, Tomasz Dzieciątkowski. Front Immunol, 2020 Jan 11; 10. PMID: 31921205 Free PMC article. Review.
Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging. Ziming Du, Jia-Ren Lin, +6 authors, Sandro Santagata. less Nat Protoc, 2019 Sep 20; 14(10). PMID: 31534232 Free PMC article.
Combined induction with anti-PD-1 and anti-CTLA-4 antibodies provides synergistic antitumor effects in DC-CIK cells in renal carcinoma cell lines. Zhaohu Yuan, Huikuan Yang, Yaming Wei. Int J Clin Exp Pathol, 2020 Jan 15; 12(1). PMID: 31933726 Free PMC article.
Amplifying Outcomes: Checkpoint Inhibitor Combinations in First-Line Non-Small Cell Lung Cancer. Barbara Melosky, Rosalyn Juergens, +5 authors, Quincy Chu. less Oncologist, 2019 May 30; 25(1). PMID: 31138727 Free PMC article.
Peptide-based targeting of immunosuppressive cells in cancer. Noah T Trac, Eun Ji Chung. Bioact Mater, 2020 Jan 21; 5(1). PMID: 31956738 Free PMC article. Review.
Fast and fierce versus slow and smooth: Heterogeneity in immune responses to Plasmodium in the controlled human malaria infection model. Xi Zen Yap, Matthew B B McCall, Robert W Sauerwein. Immunol Rev, 2019 Oct 13; 293(1). PMID: 31605396 Free PMC article. Review.
Immunotherapy in Pediatric Solid Tumors-A Systematic Review. Raoud Marayati, Colin H Quinn, Elizabeth A Beierle. Cancers (Basel), 2019 Dec 19; 11(12). PMID: 31847387 Free PMC article. Review.
Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance. Tijana Martinov, Brian T Fife. Ann N Y Acad Sci, 2019 Apr 27; 1461(1). PMID: 31025378 Free PMC article. Review.
Microenvironment-Dependent Gradient of CTL Exhaustion in the AE17sOVA Murine Mesothelioma Tumor Model. Jennifer L Hope, Panagiota I Spantidea, +9 authors, Peter D Katsikis. less Front Immunol, 2020 Jan 31; 10. PMID: 31998326 Free PMC article.
Determining macrophage versus neutrophil contributions to innate immunity using larval zebrafish. Emily E Rosowski. Dis Model Mech, 2020 Jan 15; 13(1). PMID: 31932292 Free PMC article. Review.
Inter-tumor heterogeneity of PD-L1 expression in non-small cell lung cancer. Yuichi Saito, Sho Horiuchi, +5 authors, Eishin Hoshi. less J Thorac Dis, 2020 Feb 08; 11(12). PMID: 32030214 Free PMC article.
Upcoming Revolutionary Paths in Preclinical Modeling of Pancreatic Adenocarcinoma. Mirna Swayden, Philippe Soubeyran, Juan Iovanna. Front Oncol, 2020 Feb 11; 9. PMID: 32038993 Free PMC article. Review.
Paradox-driven adventures in the development of cancer immunology and immunotherapy. Whitney Barham, Joanina K Gicobi, +2 authors, Yiyi Yan, Roxana S Dronca, Haidong Dong. less Genes Dis, 2020 Feb 12; 6(3). PMID: 32042862 Free PMC article. Review.
Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies. Hongxing Shen, Eddy Shih-Hsin Yang, +4 authors, Lewis Zhichang Shi. less Genes Dis, 2020 Feb 12; 6(3). PMID: 32042863 Free PMC article. Review.
The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer. Isabel Alvarado-Cruz, Rithy Meas, +3 authors, Joann Balazs Sweasy. less Mutagenesis, 2019 Dec 28; 35(1). PMID: 31880305 Free PMC article. Review.
Tumor mutational burden as a predictive biomarker for checkpoint inhibitor immunotherapy. Mark Lee, Robert M Samstein, +2 authors, Cristina Valero, Timothy A Chan, Luc G T Morris. less Hum Vaccin Immunother, 2019 Jul 31; 16(1). PMID: 31361563 Free PMC article.
B7-1 drives TGF-β stimulated pancreatic carcinoma cell migration and expression of EMT target genes. Jeong-Han Kang, Mi-Yeon Jung, Edward B Leof. PLoS One, 2019 Sep 05; 14(9). PMID: 31483844 Free PMC article.
Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells. Matthew B Dong, Guangchuan Wang, +17 authors, Sidi Chen. less Cell, 2019 Aug 24; 178(5). PMID: 31442407 Free PMC article.
The route of administration dictates the immunogenicity of peptide-based cancer vaccines in mice. Hussein Sultan, Takumi Kumai, +3 authors, Esteban Celis. less Cancer Immunol Immunother, 2019 Jan 04; 68(3). PMID: 30604041 Free PMC article.
Immunotherapy in Gastrointestinal Cancer: Where Do We Stand? Andrea Tannapfel, Anke Reinacher-Schick. Visc Med, 2019 Jul 18; 35(1). PMID: 31312643 Free PMC article.
Immunotherapy: Pancreatic Cancer and Extrahepatic Biliary Tract Cancer. Lukas Perkhofer, Alica K Beutel, Thomas J Ettrich. Visc Med, 2019 Jul 18; 35(1). PMID: 31312647 Free PMC article. Review.
PD-L1 Inhibitor-Induced Thyroiditis Is Associated with Better Overall Survival in Cancer Patients. Anupam Kotwal, Lisa Kottschade, Mabel Ryder. Thyroid, 2019 Dec 10; 30(2). PMID: 31813343 Free PMC article.
Structure and Optimization of Checkpoint Inhibitors. Sarah L Picardo, Jeffrey Doi, Aaron R Hansen. Cancers (Basel), 2019 Dec 28; 12(1). PMID: 31877721 Free PMC article. Review.
Efficacy and safety of immune checkpoint inhibitors in advanced gastric or gastroesophageal junction cancer: a systematic review and meta-analysis. Cong Chen, Fan Zhang, +7 authors, Yu-Min Li. less Oncoimmunology, 2019 May 10; 8(5). PMID: 31069144 Free PMC article.
Immune checkpoint modulation enhances HIV-1 antibody induction. Todd Bradley, Masayuki Kuraoka, +27 authors, Barton F Haynes. less Nat Commun, 2020 Feb 23; 11(1). PMID: 32075963 Free PMC article.
Insights Into Lung Cancer Immune-Based Biology, Prevention, and Treatment. Sara Saab, Hussein Zalzale, +3 authors, Humam Kadara. less Front Immunol, 2020 Mar 03; 11. PMID: 32117295 Free PMC article. Review.
TLR1/2 ligand enhances antitumor efficacy of CTLA-4 blockade by increasing intratumoral Treg depletion. Naveen Sharma, Jean Vacher, James P Allison. Proc Natl Acad Sci U S A, 2019 May 12; 116(21). PMID: 31076558 Free PMC article.
Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma. Megumi Goto, Kenji Chamoto, +17 authors, Tasuku Honjo. less Sci Rep, 2019 Jul 14; 9(1). PMID: 31300681 Free PMC article.
Preclinical mouse solid tumour models: status quo, challenges and perspectives. Nicolas Gengenbacher, Mahak Singhal, Hellmut G Augustin. Nat Rev Cancer, 2017 Oct 28; 17(12). PMID: 29077691 Highly Cited. Review.
CTLA-4: a moving target in immunotherapy. Behzad Rowshanravan, Neil Halliday, David M Sansom. Blood, 2017 Nov 10; 131(1). PMID: 29118008 Free PMC article. Highly Cited. Review.
Functional genomics: paving the way for more successful cancer immunotherapy. Reham Ajina, Danielle Zamalin, Louis M Weiner. Brief Funct Genomics, 2018 May 16; 18(2). PMID: 29762641 Free PMC article. Review.
Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers. Anu Sharma, Sumit K Subudhi, +6 authors, Padmanee Sharma. less Clin Cancer Res, 2018 Jul 29; 25(4). PMID: 30054281 Free PMC article. Highly Cited.
Principles of adoptive T cell therapy in cancer. Özcan Met, Kasper Mølgaard Jensen, +2 authors, Inge Marie Svane. less Semin Immunopathol, 2018 Sep 07; 41(1). PMID: 30187086 Review.
Improved Cancer Immunochemotherapy via Optimal Co-delivery of Chemotherapeutic and Immunomodulatory Agents. Yichao Chen, Jingjing Sun, +2 authors, Yixian Huang, Binfeng Lu, Song Li. less Mol Pharm, 2018 Sep 18; 15(11). PMID: 30222360 Free PMC article.
The challenges of checkpoint inhibition in the treatment of multiple myeloma. Barry Paul, Shuqi Kang, Zhihong Zheng, Yubin Kang. Cell Immunol, 2018 Oct 22; 334. PMID: 30342750 Free PMC article. Review.
High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy. Matthew M Gubin, Ekaterina Esaulova, +16 authors, Maxim N Artyomov. less Cell, 2018 Oct 23; 175(4). PMID: 30343900 Free PMC article. Highly Cited.
Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic. T A Chan, M Yarchoan, +4 authors, S Peters. less Ann Oncol, 2018 Nov 06; 30(1). PMID: 30395155 Free PMC article. Highly Cited. Review.
Immunotherapy transforms cancer treatment. Neeha Zaidi, Elizabeth M Jaffee. J Clin Invest, 2018 Dec 07; 129(1). PMID: 30507614 Free PMC article.
Antibodies to watch in 2019. Hélène Kaplon, Janice M Reichert. MAbs, 2018 Dec 06; 11(2). PMID: 30516432 Free PMC article. Highly Cited.
Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity. Chien-Chun Steven Pai, Donald M Simons, +22 authors, Lawrence Fong. less J Clin Invest, 2018 Dec 12; 129(1). PMID: 30530991 Free PMC article.
Combination Strategies to Optimize Efficacy of Dendritic Cell-Based Immunotherapy. Mandy van Gulijk, Floris Dammeijer, Joachim G J V Aerts, Heleen Vroman. Front Immunol, 2018 Dec 21; 9. PMID: 30568653 Free PMC article. Review.
Recent updates in cancer immunotherapy: a comprehensive review and perspective of the 2018 China Cancer Immunotherapy Workshop in Beijing. Zihai Li, Wenru Song, Mark Rubinstein, Delong Liu. J Hematol Oncol, 2018 Dec 24; 11(1). PMID: 30577797 Free PMC article. Highly Cited. Review.
Role of miRNAs in immune responses and immunotherapy in cancer. Maria Angelica Cortez, Simone Anfossi, +5 authors, George A Calin. less Genes Chromosomes Cancer, 2018 Dec 24; 58(4). PMID: 30578699 Free PMC article. Review.
Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries. Mohamed S Abdel-Hakeem. Viruses, 2019 Jan 30; 11(2). PMID: 30691215 Free PMC article. Review.
Immunotherapy for skin cancer. Kelly G Paulson, Miranda C Lahman, Aude G Chapuis, Isaac Brownell. Int Immunol, 2019 Feb 13; 31(7). PMID: 30753483 Free PMC article. Review.
Advances in immunotherapy delivery from implantable and injectable biomaterials. David G Leach, Simon Young, Jeffrey D Hartgerink. Acta Biomater, 2019 Feb 17; 88. PMID: 30771535 Free PMC article. Review.
The Emerging World of TCR-T Cell Trials Against Cancer: A Systematic Review. Jianxiang Zhang, Lingyu Wang. Technol Cancer Res Treat, 2019 Feb 26; 18. PMID: 30798772 Free PMC article. Highly Cited. Systematic Review.
High Expression of HLA-G in Ovarian Carcinomatosis: The Role of Interleukin-1β. Matti Ullah, Dallel Azazzen, +4 authors, Massoud Mirshahi. less Neoplasia, 2019 Feb 26; 21(3). PMID: 30802770 Free PMC article.
PD-1/PD-L1 Blockade Therapy in Advanced Non-Small-Cell Lung Cancer: Current Status and Future Directions. Liliang Xia, Yuanyong Liu, Ying Wang. Oncologist, 2019 Mar 02; 24(Suppl 1). PMID: 30819829 Free PMC article. Review.
Immune checkpoint inhibitors: an emerging cause of insulin-dependent diabetes. Anupam Kotwal, Candace Haddox, Matthew Block, Yogish C Kudva. BMJ Open Diabetes Res Care, 2019 Mar 23; 7(1). PMID: 30899528 Free PMC article. Highly Cited.
Dynamic host immune response in virus-associated cancers. Song Cao, Kristine M Wylie, +13 authors, Li Ding. less Commun Biol, 2019 Mar 27; 2. PMID: 30911684 Free PMC article.
Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota. Arthur E Frankel, Sachin Deshmukh, +8 authors, Andrew Y Koh. less Integr Cancer Ther, 2019 Apr 25; 18. PMID: 31014119 Free PMC article. Review.
Emerging therapies for small cell lung cancer. Sen Yang, Zhe Zhang, Qiming Wang. J Hematol Oncol, 2019 May 03; 12(1). PMID: 31046803 Free PMC article. Highly Cited. Review.
Intratumoral regulatory T cells: markers, subsets and their impact on anti-tumor immunity. Hiroshi Yano, Lawrence P Andrews, Creg J Workman, Dario A A Vignali. Immunology, 2019 May 16; 157(3). PMID: 31087644 Free PMC article. Highly Cited. Review.
Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D. Peter S Linsley, S Alice Long. Curr Opin Endocrinol Diabetes Obes, 2019 Jun 04; 26(4). PMID: 31157632 Free PMC article. Review.
Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies. Hao Wang, Gurbakhash Kaur, +3 authors, Xingxing Zang. less J Hematol Oncol, 2019 Jun 13; 12(1). PMID: 31186046 Free PMC article. Review.
Generating viable mice with heritable embryonically lethal mutations using the CRISPR-Cas9 system in two-cell embryos. Yi Wu, Jing Zhang, +11 authors, Songlin Wang. less Nat Commun, 2019 Jun 30; 10(1). PMID: 31253768 Free PMC article.
Macrophage-Mediated Subversion of Anti-Tumour Immunity. Valeria Quaranta, Michael C Schmid. Cells, 2019 Jul 25; 8(7). PMID: 31331034 Free PMC article. Review.
Neoantigen vaccine: an emerging tumor immunotherapy. Miao Peng, Yongzhen Mo, +10 authors, Zhaoyang Zeng. less Mol Cancer, 2019 Aug 25; 18(1). PMID: 31443694 Free PMC article. Highly Cited. Review.
Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers. Yves Lecarpentier, Olivier Schussler, Jean-Louis Hébert, Alexandre Vallée. Front Oncol, 2019 Dec 06; 9. PMID: 31803621 Free PMC article. Review.
Immunotherapy and targeted therapy-the new roadmap in cancer treatment. Kamran Shahid, Mustafa Khalife, Raetasha Dabney, Alexandria T Phan. Ann Transl Med, 2019 Dec 07; 7(20). PMID: 31807576 Free PMC article. Review.
Cancer Nano-Immunotherapy from the Injection to the Target: The Role of Protein Corona. Idoia Mikelez-Alonso, Antonio Aires, Aitziber L Cortajarena. Int J Mol Sci, 2020 Jan 18; 21(2). PMID: 31947622 Free PMC article. Review.
Immunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges. Kei Kunimasa, Taichiro Goto. Int J Mol Sci, 2020 Jan 23; 21(2). PMID: 31963413 Free PMC article. Review.
Immunotherapy Outcomes in Advanced Melanoma in Relation to Age. Krishna Joshi, Dinesh Atwal, +6 authors, Fade Mahmoud. less Perm J, 2020 Feb 26; 24. PMID: 32097116 Free PMC article.
A phase II open label, randomised study of ipilimumab with temozolomide versus temozolomide alone after surgery and chemoradiotherapy in patients with recently diagnosed glioblastoma: the Ipi-Glio trial protocol. Nicholas F Brown, Stasya M Ng, +8 authors, Paul Mulholland. less BMC Cancer, 2020 Mar 14; 20(1). PMID: 32164579 Free PMC article.
Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours. Ellen Brenner, Barbara F Schörg, +32 authors, Martin Röcken. less Nat Commun, 2020 Mar 14; 11(1). PMID: 32165639 Free PMC article.
Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses. Yu Chao, Chao Liang, +11 authors, Zhuang Liu. less Sci Adv, 2020 Mar 18; 6(10). PMID: 32181368 Free PMC article.
Targeting CD47 as a Novel Immunotherapy for Multiple Myeloma. Jennifer Sun, Barbara Muz, +11 authors, Abdel Kareem Azab. less Cancers (Basel), 2020 Feb 06; 12(2). PMID: 32012878 Free PMC article.
Ipilimumab and Its Derived EGFR Aptamer-Based Conjugate Induce Efficient NK Cell Activation against Cancer Cells. Margherita Passariello, Simona Camorani, +3 authors, Claudia De Lorenzo. less Cancers (Basel), 2020 Feb 07; 12(2). PMID: 32024070 Free PMC article.
An unexpected turn of fortune: targeting TRAIL-Rs in KRAS-driven cancer. Silvia von Karstedt, Henning Walczak. Cell Death Discov, 2020 Mar 21; 6. PMID: 32194994 Free PMC article. Review.
The past, present, and future of costimulation blockade in organ transplantation. Paul M Schroder, Zachary W Fitch, +3 authors, Stuart J Knechtle. less Curr Opin Organ Transplant, 2019 Jun 04; 24(4). PMID: 31157670 Free PMC article. Review.
The role of T cell trafficking in CTLA-4 blockade-induced gut immunopathology. Shashuang Zhang, Wenhua Liang, +2 authors, Lingjie Luo, Shan Sun, Feng Wang. less BMC Biol, 2020 Mar 19; 18(1). PMID: 32183814 Free PMC article.
Novel calreticulin-nanoparticle in combination with focused ultrasound induces immunogenic cell death in melanoma to enhance antitumor immunity. Sri Nandhini Sethuraman, Mohit Pratap Singh, +6 authors, Ashish Ranjan. less Theranostics, 2020 Mar 25; 10(8). PMID: 32206098 Free PMC article.
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Qingsong Hu, Youqiong Ye, +34 authors, Liuqing Yang. less Nat Immunol, 2019 Jun 05; 20(7). PMID: 31160797 Free PMC article. Highly Cited.
Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy. Ryusuke Hatae, Kenji Chamoto, +13 authors, Tasuku Honjo. less JCI Insight, 2019 Dec 20; 5(2). PMID: 31855576 Free PMC article.
Mouse Systems Genetics as a Prelude to Precision Medicine. Hao Li, Johan Auwerx. Trends Genet, 2020 Feb 11; 36(4). PMID: 32037011 Free PMC article. Review.
The risks of targeting co-inhibitory pathways to modulate pathogen-directed T cell responses. Helge Frebel, Annette Oxenius. Trends Immunol, 2013 Jan 22; 34(5). PMID: 23333205 Free PMC article. Review.
Inhibition of SHP-1 Expands the Repertoire of Antitumor T Cells Available to Respond to Immune Checkpoint Blockade. Jeremy P Snook, Ashleigh J Soedel, +2 authors, H Atakan Ekiz, Ryan M O'Connell, Matthew A Williams. less Cancer Immunol Res, 2020 Feb 23; 8(4). PMID: 32075800 Free PMC article.
Human monoclonal antibodies from transgenic mice. N Lonberg. Handb Exp Pharmacol, 2007 Dec 12; (181). PMID: 18071942 Free PMC article. Review.
The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity. Alexandra Schnell, Lloyd Bod, Asaf Madi, Vijay K Kuchroo. Cell Res, 2020 Jan 25; 30(4). PMID: 31974523 Free PMC article. Review.
Next-generation immuno-oncology agents: current momentum shifts in cancer immunotherapy. Chongxian Pan, Hongtao Liu, +4 authors, Lei Zheng. less J Hematol Oncol, 2020 Apr 05; 13(1). PMID: 32245497 Free PMC article. Review.
Development of immune checkpoint therapy for cancer. Jill M Fritz, Michael J Lenardo. J Exp Med, 2019 May 10; 216(6). PMID: 31068379 Free PMC article. Highly Cited. Review.
Immunotherapy: From Advanced NSCLC to Early Stages, an Evolving Concept. Thierry Berghmans, Valérie Durieux, Lizza E L Hendriks, Anne-Marie Dingemans. Front Med (Lausanne), 2020 Apr 09; 7. PMID: 32266275 Free PMC article. Systematic Review.
Can Immunogenic Chemotherapies Relieve Cancer Cell Resistance to Immune Checkpoint Inhibitors? Thaiz Rivera Vargas, Lionel Apetoh. Front Immunol, 2019 Jun 14; 10. PMID: 31191545 Free PMC article. Review.
Rationale for Combining Radiotherapy and Immune Checkpoint Inhibition for Patients With Hypoxic Tumors. Franziska Eckert, Kerstin Zwirner, +3 authors, Stephan M Huber. less Front Immunol, 2019 Apr 02; 10. PMID: 30930892 Free PMC article. Review.
Autologous Hematopoietic Stem Cells Are a Preferred Source to Generate Dendritic Cells for Immunotherapy in Multiple Myeloma Patients. Prajakta Shinde, Sameer Melinkeri, +2 authors, Manas Kumar Santra, Vaijayanti Kale, Lalita Limaye. less Front Immunol, 2019 Jun 06; 10. PMID: 31164886 Free PMC article.
The Tolerogenic Function of Regulatory T Cells in Pregnancy and Cancer. Nanna Jørgensen, Gry Persson, Thomas Vauvert F Hviid. Front Immunol, 2019 May 28; 10. PMID: 31134056 Free PMC article. Review.
Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection. Annarosaria De Vito, Paola Orecchia, +6 authors, Lorenzo Mortara. less Cancers (Basel), 2020 Mar 22; 12(3). PMID: 32197460 Free PMC article.
CD38 in Adenosinergic Pathways and Metabolic Re-programming in Human Multiple Myeloma Cells: In-tandem Insights From Basic Science to Therapy. Alberto L Horenstein, Cristiano Bracci, Fabio Morandi, Fabio Malavasi. Front Immunol, 2019 May 10; 10. PMID: 31068926 Free PMC article. Review.
PD-L1 Distribution and Perspective for Cancer Immunotherapy-Blockade, Knockdown, or Inhibition. Yilun Wu, Weiyu Chen, Zhi Ping Xu, Wenyi Gu. Front Immunol, 2019 Sep 12; 10. PMID: 31507611 Free PMC article. Highly Cited. Review.
Preponderance of CTLA4 Variation Associated With Autosomal Dominant Immune Dysregulation in the MYPPPY Motif. Owen M Siggs, Amanda Russell, +6 authors, Christopher C Goodnow. less Front Immunol, 2019 Aug 10; 10. PMID: 31396201 Free PMC article.
Tuning the Tumor Myeloid Microenvironment to Fight Cancer. Nadine S Jahchan, Adriana M Mujal, +4 authors, Matthew F Krummel. less Front Immunol, 2019 Aug 14; 10. PMID: 31402908 Free PMC article. Review.
Mechanisms of checkpoint inhibition-induced adverse events. P Urwyler, I Earnshaw, +9 authors, S Papa. less Clin Exp Immunol, 2020 Jan 29; 200(2). PMID: 31989585 Free PMC article. Review.
Role of inflammasome activation in tumor immunity triggered by immune checkpoint blockers. M Segovia, S Russo, +2 authors, M R Girotti, G A Rabinovich, M Hill. less Clin Exp Immunol, 2020 Apr 17; 200(2). PMID: 32297328 Free PMC article. Review.
Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors. Rachel Grosser, Leonid Cherkassky, Navin Chintala, Prasad S Adusumilli. Cancer Cell, 2019 Nov 13; 36(5). PMID: 31715131 Free PMC article. Review.
Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Jun Wang, Jingwei Sun, +16 authors, Lieping Chen. less Nat Med, 2019 Mar 06; 25(4). PMID: 30833750 Free PMC article. Highly Cited.
Sustained Coevolution in a Stochastic Model of Cancer-Immune Interaction. Jason T George, Herbert Levine. Cancer Res, 2019 Dec 22; 80(4). PMID: 31862779 Free PMC article.
Modeling clear cell renal cell carcinoma and therapeutic implications. Melissa M Wolf, W Kimryn Rathmell, Kathryn E Beckermann. Oncogene, 2020 Mar 04; 39(17). PMID: 32123314 Free PMC article. Review.
Current Status of Immunotherapies for Treating Pancreatic Cancer. Annie A Wu, Elizabeth Jaffee, Valerie Lee. Curr Oncol Rep, 2019 May 19; 21(7). PMID: 31101991 Review.
Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy. Ilenia Aversa, Donatella Malanga, Giuseppe Fiume, Camillo Palmieri. Int J Mol Sci, 2020 Apr 03; 21(7). PMID: 32235561 Free PMC article. Review.
T cell costimulation, checkpoint inhibitors and anti-tumor therapy. Dipankar Nandi, Sanmoy Pathak, +6 authors, Vijayamahantesh. less J Biosci, 2020 Apr 30; 45. PMID: 32345776 Review.
Targeted Therapies Combined With Immune Checkpoint Therapy. Peter A Prieto, Alexandre Reuben, Zachary A Cooper, Jennifer A Wargo. Cancer J, 2016 Apr 26; 22(2). PMID: 27111910 Free PMC article. Review.
Tumor Targeted Nanocarriers for Immunotherapy. Alejandro Baeza. Molecules, 2020 Apr 01; 25(7). PMID: 32225049 Free PMC article. Review.
RIP3 promotes colitis-associated colorectal cancer by controlling tumor cell proliferation and CXCL1-induced immune suppression. Zhen-Yu Liu, Ming Zheng, +9 authors, Zhi-Nan Chen. less Theranostics, 2019 Jul 10; 9(12). PMID: 31281505 Free PMC article.
IL36 Cooperates With Anti-CTLA-4 mAbs to Facilitate Antitumor Immune Responses. Qiuxia Qu, Zhiwei Zhai, +3 authors, Jieni Xu, Song Li, Cheng Chen, Binfeng Lu. less Front Immunol, 2020 May 01; 11. PMID: 32351508 Free PMC article.
Small molecule immunomodulation: the tumor microenvironment and overcoming immune escape. Arsen Osipov, May Tun Saung, Lei Zheng, Adrian G Murphy. J Immunother Cancer, 2019 Aug 24; 7(1). PMID: 31439034 Free PMC article. Review.
Current issues and perspectives in PD-1 blockade cancer immunotherapy. Kenji Chamoto, Ryusuke Hatae, Tasuku Honjo. Int J Clin Oncol, 2020 Jan 05; 25(5). PMID: 31900651 Free PMC article. Review.
A new hope. R Wong. Curr Oncol, 2020 May 06; 27(Suppl 2). PMID: 32368172 Free PMC article.
Species Classification for Neuroscience Literature Based on Span of Interest Using Sequence-to-Sequence Learning Model. Hongyin Zhu, Yi Zeng, Dongsheng Wang, Cunqing Huangfu. Front Hum Neurosci, 2020 May 07; 14. PMID: 32372933 Free PMC article.
Preserving the CTLA-4 Checkpoint for Safer and More Effective Cancer Immunotherapy. Yang Liu, Pan Zheng. Trends Pharmacol Sci, 2019 Dec 15; 41(1). PMID: 31836191 Free PMC article. Review.
Evaluation of survival extrapolation in immuno-oncology using multiple pre-planned data cuts: learnings to aid in model selection. Ash Bullement, Anna Willis, +3 authors, Murtuza Bharmal. less BMC Med Res Methodol, 2020 May 08; 20(1). PMID: 32375680 Free PMC article.
NK cells mediate clearance of CD8+ T cell-resistant tumors in response to STING agonists. Christopher J Nicolai, Natalie Wolf, +5 authors, David H Raulet. less Sci Immunol, 2020 Mar 22; 5(45). PMID: 32198222 Free PMC article.
Exploiting immune-dependent effects of microtubule-targeting agents to improve efficacy and tolerability of cancer treatment. Angela Flavia Serpico, Roberta Visconti, Domenico Grieco. Cell Death Dis, 2020 May 14; 11(5). PMID: 32398657 Free PMC article. Review.
Anti-PDL1 effect in squamous non-small cell lung cancer. Mohamed Rahouma, Massimo Baudo, +2 authors, Mohamed Kamel, Nagla Abdel Karim, Nasser Altorki. less Transl Lung Cancer Res, 2020 May 19; 9(2). PMID: 32420083 Free PMC article.
Thymic Function Associated With Cancer Development, Relapse, and Antitumor Immunity - A Mini-Review. Weikan Wang, Rachel Thomas, Olga Sizova, Dong-Ming Su. Front Immunol, 2020 May 20; 11. PMID: 32425946 Free PMC article. Review.
Talkin' Toxins: From Coley's to Modern Cancer Immunotherapy. Robert D Carlson, John C Flickinger, Adam E Snook. Toxins (Basel), 2020 Apr 15; 12(4). PMID: 32283684 Free PMC article. Review.
microRNAs in the Antitumor Immune Response and in Bone Metastasis of Breast Cancer: From Biological Mechanisms to Therapeutics. Marta Gomarasca, Paola Maroni, Giuseppe Banfi, Giovanni Lombardi. Int J Mol Sci, 2020 Apr 23; 21(8). PMID: 32316552 Free PMC article. Review.
A guide to cancer immunotherapy: from T cell basic science to clinical practice. Alex D Waldman, Jill M Fritz, Michael J Lenardo. Nat Rev Immunol, 2020 May 21; 20(11). PMID: 32433532 Free PMC article. Review.
Nanotechnology Promotes Genetic and Functional Modifications of Therapeutic T Cells Against Cancer. Ahmed M E Abdalla, Lin Xiao, +5 authors, Guang Yang. less Adv Sci (Weinh), 2020 May 23; 7(10). PMID: 32440473 Free PMC article. Review.
The abscopal effect 67 years later: from a side story to center stage. Sandra Demaria, Silvia C Formenti. Br J Radiol, 2020 Feb 27; 93(1109). PMID: 32101479 Free PMC article. Review.
The emerging role of epigenetic therapeutics in immuno-oncology. Michael J Topper, Michelle Vaz, +2 authors, Kristen A Marrone, Julie R Brahmer, Stephen B Baylin. less Nat Rev Clin Oncol, 2019 Sep 25; 17(2). PMID: 31548600 Free PMC article. Review.
Early prediction of pathologic response to neoadjuvant treatment of breast cancer: use of a cell-loss metric based on serum thymidine kinase 1 and tumour volume. Bernhard Tribukait. BMC Cancer, 2020 May 20; 20(1). PMID: 32423477 Free PMC article.
ST2 as checkpoint target for colorectal cancer immunotherapy. Kevin Van der Jeught, Yifan Sun, +17 authors, Xiongbin Lu. less JCI Insight, 2020 May 08; 5(9). PMID: 32376804 Free PMC article.
Scientific Rationale for Combination Immunotherapy of Hepatocellular Carcinoma with Anti-PD-1/PD-L1 and Anti-CTLA-4 Antibodies. Masatoshi Kudo. Liver Cancer, 2020 Jun 02; 8(6). PMID: 32479569 Free PMC article.
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. Louise van der Weyden, Agnieszka Swiatkowska, +2 authors, Vivek Iyer, Anneliese O Speak, David J Adams. less G3 (Bethesda), 2020 Apr 05; 10(6). PMID: 32245826 Free PMC article.
The Role of Immune Checkpoints after Cellular Therapy. Friederike Schmitz, Dominik Wolf, Tobias A W Holderried. Int J Mol Sci, 2020 May 28; 21(10). PMID: 32455836 Free PMC article. Review.
Preparation of Biphenyl-Conjugated Bromotyrosine for Inhibition of PD-1/PD-L1 Immune Checkpoint Interactions. Eun-Hye Kim, Masuki Kawamoto, +3 authors, Hideyuki Miyatake. less Int J Mol Sci, 2020 May 28; 21(10). PMID: 32455628 Free PMC article.
The Cancer-Immune Set Point in Oesophageal Cancer. Robert Power, Maeve A Lowery, John V Reynolds, Margaret R Dunne. Front Oncol, 2020 Jun 26; 10. PMID: 32582553 Free PMC article. Review.
Human cancer germline antigen-specific cytotoxic T cell-what can we learn from patient. Megat Abd Hamid, Yanchun Peng, Tao Dong. Cell Mol Immunol, 2020 May 27; 17(7). PMID: 32451453 Free PMC article. Review.
Systemic therapy for advanced clear cell renal cell carcinoma after discontinuation of immune-oncology and VEGF targeted therapy combinations. Yasser Ged, Ruby Gupta, +10 authors, Chung-Han Lee. less BMC Urol, 2020 Jul 04; 20(1). PMID: 32616076 Free PMC article.
Upregulation of Multiple CD8+ T Cell Exhaustion Pathways Is Associated with Recurrent Ocular Herpes Simplex Virus Type 1 Infection. Pierre-Grégoire Coulon, Soumyabrata Roy, +12 authors, Lbachir BenMohamed. less J Immunol, 2020 Jun 17; 205(2). PMID: 32540992 Free PMC article.
Altering the response to radiation: radiosensitizers and targeted therapies in pancreatic ductal adenocarcinoma: preclinical and emerging clinical evidence. Adam R Wolfe, Terence M Williams. Ann Pancreat Cancer, 2018 Aug 01; 1(8). PMID: 32656528 Free PMC article.
Comprehensive review of targeted therapy for colorectal cancer. Yuan-Hong Xie, Ying-Xuan Chen, Jing-Yuan Fang. Signal Transduct Target Ther, 2020 Apr 17; 5(1). PMID: 32296018 Free PMC article. Review.
PD-1: Its Discovery, Involvement in Cancer Immunotherapy, and Beyond. Yasumasa Ishida. Cells, 2020 Jun 05; 9(6). PMID: 32492969 Free PMC article. Review.
Surface-Enhanced Raman Spectroscopy for Cancer Immunotherapy Applications: Opportunities, Challenges, and Current Progress in Nanomaterial Strategies. Shuvashis Dey, Matt Trau, Kevin M Koo. Nanomaterials (Basel), 2020 Jun 18; 10(6). PMID: 32545182 Free PMC article. Review.
Prognostic value of immune checkpoint molecules in breast cancer. Jun Fang, Feng Chen, +3 authors, Dong Liu, Feiying Gu, Zhigang Chen, Yuezhen Wang. less Biosci Rep, 2020 Jul 01; 40(7). PMID: 32602545 Free PMC article.
Radiation Dose Escalation is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance Local and Distant Antitumor Effect in Murine Osteosarcoma. Wataru Takenaka, Yutaka Takahashi, +6 authors, Kazuhiko Ogawa. less Cancers (Basel), 2020 Jun 18; 12(6). PMID: 32545427 Free PMC article.
Immunological Targets for Immunotherapy: Inhibitory T Cell Receptors. Diwakar Davar, Hassane M Zarour. Methods Mol Biol, 2019 Sep 11; 2055. PMID: 31502146 Free PMC article. Review.
Cancer immunotherapy using checkpoint blockade. Antoni Ribas, Jedd D Wolchok. Science, 2018 Mar 24; 359(6382). PMID: 29567705 Free PMC article. Highly Cited. Review.
Cutaneous melanoma and the immunotherapy revolution (Review). Giulia C Leonardi, Saverio Candido, +2 authors, Luca Falzone, Demetrios A Spandidos, Massimo Libra. less Int J Oncol, 2020 Jun 26; 57(3). PMID: 32582963 Free PMC article. Review.
Identification and validation of tumor microenvironment-related genes of prognostic value in lung adenocarcinoma. Jingyan Yuan, Bo Yuan, +7 authors, Shuanying Yang. less Oncol Lett, 2020 Jul 30; 20(2). PMID: 32724420 Free PMC article.
The promise of combining cancer vaccine and checkpoint blockade for treating HPV-related cancer. Takeo Shibata, Benjamin J Lieblong, Toshiyuki Sasagawa, Mayumi Nakagawa. Cancer Treat Rev, 2019 Jul 16; 78. PMID: 31302573 Free PMC article. Review.
Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10. Shan-Shan Yin, Feng-Hou Gao. Front Immunol, 2020 Aug 09; 11. PMID: 32765491 Free PMC article. Review.
Cancer Cell Metabolism Bolsters Immunotherapy Resistance by Promoting an Immunosuppressive Tumor Microenvironment. Zhou Jiang, Jennifer L Hsu, +2 authors, Yintao Li, Gabriel N Hortobagyi, Mien-Chie Hung. less Front Oncol, 2020 Aug 11; 10. PMID: 32775303 Free PMC article. Review.
Immune Checkpoint Inhibitors and Immune-Related Adverse Renal Events. Sandra M Herrmann, Mark A Perazella. Kidney Int Rep, 2020 Aug 11; 5(8). PMID: 32775813 Free PMC article. Review.
Necroptotic-susceptible dendritic cells exhibit enhanced antitumor activities in mice. Zhanran Zhao, Guangzhi Zhang, Yuefang Sun, Astar Winoto. Immun Inflamm Dis, 2020 Jul 15; 8(3). PMID: 32663380 Free PMC article.
Harnessing NK Cell Checkpoint-Modulating Immunotherapies. Sachin Kumar Singh Chauhan, Ulrike Koehl, Stephan Kloess. Cancers (Basel), 2020 Jul 10; 12(7). PMID: 32640575 Free PMC article. Review.
Molecular Mechanisms and Potential Therapeutic Reversal of Pancreatic Cancer-Induced Immune Evasion. Li-Lian Gan, Ling-Wei Hii, +2 authors, Shew-Fung Wong, Chee-Onn Leong, Chun-Wai Mai. less Cancers (Basel), 2020 Jul 16; 12(7). PMID: 32664564 Free PMC article. Review.
Immune Checkpoint Inhibitors for Brain Metastases: A Primer for Neurosurgeons. Elisa Aquilanti, Priscilla K Brastianos. Neurosurgery, 2020 Apr 18; 87(3). PMID: 32302389 Free PMC article. Review.
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications. Yuanyuan Zhang, Zemin Zhang. Cell Mol Immunol, 2020 Jul 03; 17(8). PMID: 32612154 Free PMC article. Review.
A Review of T-Cell Related Therapy for Osteosarcoma. Kazushige Yoshida, Masanori Okamoto, +2 authors, Kaoru Aoki, Jun Takahashi, Naoto Saito. less Int J Mol Sci, 2020 Jul 16; 21(14). PMID: 32664248 Free PMC article. Review.
B-cell epitope peptide cancer vaccines: a new paradigm for combination immunotherapies with novel checkpoint peptide vaccine. Pravin Tp Kaumaya. Future Oncol, 2020 Jun 23; 16(23). PMID: 32564612 Free PMC article. Review.
Administration of low-dose combination anti-CTLA4, anti-CD137, and anti-OX40 into murine tumor or proximal to the tumor draining lymph node induces systemic tumor regression. Jonathan P O Hebb, Adriane R Mosley, +4 authors, Dean W Felsher. less Cancer Immunol Immunother, 2017 Sep 15; 67(1). PMID: 28905118 Free PMC article.
Advances in Anti-Cancer Immunotherapy: Car-T Cell, Checkpoint Inhibitors, Dendritic Cell Vaccines, and Oncolytic Viruses, and Emerging Cellular and Molecular Targets. Emilie Alard, Aura-Bianca Butnariu, +5 authors, Md Zahidul Islam Pranjol. less Cancers (Basel), 2020 Jul 11; 12(7). PMID: 32645977 Free PMC article. Review.
Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy. Lukas Amon, Lukas Hatscher, +2 authors, Lukas Heger, Diana Dudziak, Christian H K Lehmann. less Pharmaceutics, 2020 Jul 18; 12(7). PMID: 32674488 Free PMC article. Review.
Nivolumab plus Ipilimumab versus Existing Immunotherapies in Patients with PD-L1-Positive Advanced Non-Small Cell Lung Cancer: A Systematic Review and Network Meta-Analysis. Koichi Ando, Yasunari Kishino, +6 authors, Hironori Sagara. less Cancers (Basel), 2020 Jul 19; 12(7). PMID: 32679702 Free PMC article. Review.
Strategies for Deliberate Induction of Immune Tolerance in Liver Transplantation: From Preclinical Models to Clinical Application. Naoki Tanimine, Masahiro Ohira, +4 authors, Hideki Ohdan. less Front Immunol, 2020 Aug 28; 11. PMID: 32849546 Free PMC article. Review.
Biological Landscape of Triple Negative Breast Cancers Expressing CTLA-4. María G C Navarrete-Bernal, Mayte G Cervantes-Badillo, +14 authors, Leticia Rocha-Zavaleta. less Front Oncol, 2020 Aug 28; 10. PMID: 32850353 Free PMC article.
Scientifically based combination therapies with immuno-oncology checkpoint inhibitors. Hui Yi Chew, Riccardo Dolcetti, Fiona Simpson. Br J Clin Pharmacol, 2020 May 07; 86(9). PMID: 32372470 Free PMC article. Review.
Immune checkpoint blockade in solid organ tumours: Choice, dose and predictors of response. Vishal Navani, Moira C Graves, Nikola A Bowden, Andre Van Der Westhuizen. Br J Clin Pharmacol, 2020 May 10; 86(9). PMID: 32384184 Free PMC article. Review.
Combination of PD-L1 and PVR determines sensitivity to PD-1 blockade. Bo Ryeong Lee, Sehyun Chae, +8 authors, Sang-Jun Ha. less JCI Insight, 2020 Jun 20; 5(14). PMID: 32554931 Free PMC article.
Human immunology and immunotherapy: main achievements and challenges. Jezabel Varadé, Susana Magadán, África González-Fernández. Cell Mol Immunol, 2020 Sep 04; 18(4). PMID: 32879472 Free PMC article. Review.
Isolation of Two Novel Human Anti-CTLA-4 mAbs with Intriguing Biological Properties on Tumor and NK Cells. Margherita Passariello, Cinzia Vetrei, +7 authors, Claudia De Lorenzo. less Cancers (Basel), 2020 Aug 13; 12(8). PMID: 32781690 Free PMC article.
Photoacoustic-immune therapy with a multi-purpose black phosphorus-based nanoparticle. Fanchu Zeng, Huan Qin, +6 authors, Da Xing. less Nano Res, 2020 Sep 10;. PMID: 32904446 Free PMC article.
Combinatorial approach to cancer immunotherapy: strength in numbers. Anna E Vilgelm, Douglas B Johnson, Ann Richmond. J Leukoc Biol, 2016 Jun 04; 100(2). PMID: 27256570 Free PMC article. Review.
Protein Footprinting and X-ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide. Ben Niu, Todd C Appleby, +11 authors, Michael L Gross. less Biochemistry, 2019 Dec 17; 59(4). PMID: 31841311 Free PMC article.
TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy. Martina Molgora, Ekaterina Esaulova, +18 authors, Marco Colonna. less Cell, 2020 Aug 14; 182(4). PMID: 32783918 Free PMC article.
Endocrine Adverse Events of Nivolumab in Non-Small Cell Lung Cancer Patients-Literature Review. Marta Dudzińska, Michał Szczyrek, +3 authors, Agnieszka Zwolak. less Cancers (Basel), 2020 Aug 23; 12(8). PMID: 32824462 Free PMC article. Review.
Generation of highly activated, antigen-specific tumor-infiltrating CD8+ T cells induced by a novel T cell-targeted immunotherapy. Ava Vila-Leahey, Alecia MacKay, +3 authors, Marianne M Stanford. less Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923145 Free PMC article.
Mechanisms and microbial influences on CTLA-4 and PD-1-based immunotherapy in the treatment of cancer: a narrative review. Peter L Miller, Tiffany L Carson. Gut Pathog, 2020 Sep 19; 12. PMID: 32944086 Free PMC article. Review.
Does the Immunocompetent Status of Cancer Patients Have an Impact on Therapeutic DC Vaccination Strategies? Silvia Martin Lluesma, Michele Graciotti, Cheryl Lai-Lai Chiang, Lana E Kandalaft. Vaccines (Basel), 2018 Nov 28; 6(4). PMID: 30477198 Free PMC article. Review.
Current Options and Future Directions in Immune Therapy for Glioblastoma. John Lynes, Victoria Sanchez, +2 authors, Gifty Dominah, Anthony Nwankwo, Edjah Nduom. less Front Oncol, 2018 Dec 21; 8. PMID: 30568917 Free PMC article. Review.
2018 Nobel Prize in medicine awarded to cancer immunotherapy: Immune checkpoint blockade - A personal account. Xingxing Zang. Genes Dis, 2018 Dec 29; 5(4). PMID: 30591930 Free PMC article.
Radiation, Immune Checkpoint Blockade and the Abscopal Effect: A Critical Review on Timing, Dose and Fractionation. Zachary S Buchwald, Jacob Wynne, +6 authors, Mohammad K Khan. less Front Oncol, 2019 Jan 09; 8. PMID: 30619752 Free PMC article. Highly Cited. Review.
Cytokines, Chemokines, and Other Biomarkers of Response for Checkpoint Inhibitor Therapy in Skin Cancer. Jennifer A Bridge, James C Lee, +2 authors, Adil Daud, James W Wells, Jeffrey A Bluestone. less Front Med (Lausanne), 2019 Jan 12; 5. PMID: 30631766 Free PMC article. Review.
Heart failure in cancer: role of checkpoint inhibitors. Murilo Delgobo, Stefan Frantz. J Thorac Dis, 2019 Feb 01; 10(Suppl 35). PMID: 30701100 Free PMC article. Review.
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells. Fiamma Salerno, Aurelie Guislain, +3 authors, Monika C Wolkers. less Oncoimmunology, 2019 Feb 05; 8(2). PMID: 30713785 Free PMC article.
Integrating Small Animal Irradiators withFunctional Imaging for Advanced Preclinical Radiotherapy Research. Mihaela Ghita, Kathryn H Brown, +2 authors, Olivia J Kelada, Edward E Graves, Karl T Butterworth. less Cancers (Basel), 2019 Feb 06; 11(2). PMID: 30717307 Free PMC article. Review.
Advances in immune checkpoint inhibitors for bone sarcoma therapy. Pichaya Thanindratarn, Dylan C Dean, +2 authors, Scott D Nelson, Francis J Hornicek, Zhenfeng Duan. less J Bone Oncol, 2019 Feb 19; 15. PMID: 30775238 Free PMC article. Highly Cited. Review.
Immune checkpoint inhibitors: Advances and impact in neuro-oncology. Jawad Fares, Mohamad Y Fares, Youssef Fares. Surg Neurol Int, 2019 Feb 21; 10. PMID: 30783540 Free PMC article.
On the Other Side: Manipulating the Immune Checkpoint Landscape of Dendritic Cells to Enhance Cancer Immunotherapy. Benjamin Y Kong, Holly Bolton, +3 authors, Georgina J Clark. less Front Oncol, 2019 Feb 23; 9. PMID: 30788290 Free PMC article. Review.
Mouse-Derived Isograft (MDI) In Vivo Tumor Models I. Spontaneous sMDI Models: Characterization and Cancer Therapeutic Approaches. Peter Jantscheff, Janette Beshay, +3 authors, Holger Weber. less Cancers (Basel), 2019 Feb 23; 11(2). PMID: 30791466 Free PMC article.
Functionalized Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as Platform for the Targeted Multimodal Tumor Therapy. Christina Janko, Teresa Ratschker, +4 authors, Christoph Alexiou. less Front Oncol, 2019 Mar 01; 9. PMID: 30815389 Free PMC article.
Immune checkpoint inhibitor-induced colitis: A comprehensive review. Aniruddh Som, Rohan Mandaliya, +4 authors, Mark C Mattar. less World J Clin Cases, 2019 Mar 08; 7(4). PMID: 30842952 Free PMC article. Highly Cited. Review.
Harnessing Radiation Biology to Augment Immunotherapy for Glioblastoma. Karishma R Rajani, Lucas P Carlstrom, +3 authors, Terry C Burns. less Front Oncol, 2019 Mar 12; 8. PMID: 30854331 Free PMC article. Review.
Risk and incidence of fatal adverse events associated with immune checkpoint inhibitors: a systematic review and meta-analysis. Yi Jiang, Ning Zhang, +2 authors, Hailin Pang, Xiaobo Gao, Helong Zhang. less Ther Clin Risk Manag, 2019 Mar 13; 15. PMID: 30858709 Free PMC article.
Turning "Cold" Into "Hot" Tumors-Opportunities and Challenges for Radio-Immunotherapy Against Primary and Metastatic Brain Cancers. Lisa Sevenich. Front Oncol, 2019 Apr 04; 9. PMID: 30941312 Free PMC article. Review.
Targeted Therapies and Immune-Checkpoint Inhibition in Head and Neck Squamous Cell Carcinoma: Where Do We Stand Today and Where to Go? Jens von der Grün, Franz Rödel, +4 authors, Panagiotis Balermpas. less Cancers (Basel), 2019 Apr 17; 11(4). PMID: 30987257 Free PMC article. Review.
The Discovery of Biomarkers in Cancer Immunotherapy. Anil P George, Timothy M Kuzel, Yi Zhang, Bin Zhang. Comput Struct Biotechnol J, 2019 Apr 24; 17. PMID: 31011407 Free PMC article. Review.
Immune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer Therapy. Daniele Lecis, Sabina Sangaletti, Mario P Colombo, Claudia Chiodoni. Cancers (Basel), 2019 May 08; 11(5). PMID: 31060225 Free PMC article. Review.
Costimulatory and coinhibitory immune checkpoint receptors in head and neck cancer: unleashing immune responses through therapeutic combinations. Ruth J Davis, Robert L Ferris, Nicole C Schmitt. Cancers Head Neck, 2016 Oct 01; 1. PMID: 31093342 Free PMC article. Review.
Informatics and Computational Methods in Natural Product Drug Discovery: A Review and Perspectives. Joseph D Romano, Nicholas P Tatonetti. Front Genet, 2019 May 23; 10. PMID: 31114606 Free PMC article. Review.
Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy. Esteban Cruz, Veysel Kayser. Biologics, 2019 May 24; 13. PMID: 31118560 Free PMC article. Highly Cited. Review.
Expression of PD-1 and CTLA-4 Are Negative Prognostic Markers in Renal Cell Carcinoma. Andreas Kahlmeyer, Christine G Stöhr, +5 authors, Franziska Erlmeier. less J Clin Med, 2019 May 30; 8(5). PMID: 31137694 Free PMC article.
Editorial: Management of Immune-Related Adverse Events for Patients Undergoing Treatment With Checkpoint Inhibitors. Bernardo Leon Rapoport. Front Oncol, 2019 Jun 04; 9. PMID: 31157163 Free PMC article.
In silico simulation of a clinical trial with anti-CTLA-4 and anti-PD-L1 immunotherapies in metastatic breast cancer using a systems pharmacology model. Hanwen Wang, Oleg Milberg, +6 authors, Aleksander S Popel. less R Soc Open Sci, 2019 Jun 21; 6(5). PMID: 31218069 Free PMC article.
Identification of hub genes and key pathways associated with angioimmunoblastic T-cell lymphoma using weighted gene co-expression network analysis. Xiaoqian Li, Zijian Liu, +5 authors, Liling Zhang. less Cancer Manag Res, 2019 Jun 27; 11. PMID: 31239775 Free PMC article.
Combination pembrolizumab plus chemotherapy: a new standard of care for patients with advanced non-small-cell lung cancer. Frank Weinberg, Shirish Gadgeel. Lung Cancer (Auckl), 2019 Jun 27; 10. PMID: 31239797 Free PMC article.
Aging, Cancer and Immunity. Hong Hong, Qi Wang, +3 authors, Jing Li, Hans Liu, Xin Meng, Haiyan Zhang. less J Cancer, 2019 Jul 10; 10(13). PMID: 31281479 Free PMC article. Review.
Immunotherapy for hepatocellular carcinoma: recent advances and future perspectives. Weiqi Xu, Ken Liu, +4 authors, Jiansong Ji. less Ther Adv Med Oncol, 2019 Aug 07; 11. PMID: 31384311 Free PMC article. Review.
The Tumor Microenvironment in Colorectal Cancer Therapy. Leire Pedrosa, Francis Esposito, Timothy M Thomson, Joan Maurel. Cancers (Basel), 2019 Aug 17; 11(8). PMID: 31416205 Free PMC article. Review.
Immune checkpoint inhibitor-induced diarrhea/colitis: Endoscopic and pathologic findings. Tsutomu Nishida, Hideki Iijima, Shiro Adachi. World J Gastrointest Pathophysiol, 2019 Sep 29; 10(2). PMID: 31559106 Free PMC article. Review.
Tissue Site and the Cancer Immunity Cycle. Brendan L Horton, Tim B Fessenden, Stefani Spranger. Trends Cancer, 2019 Nov 11; 5(10). PMID: 31706507 Free PMC article. Review.
Interaction between Immunotherapy and Antiangiogenic Therapy for Cancer. Koichi Furukawa, Tatsuya Nagano, +2 authors, Motoko Tachihara, Masatsugu Yamamoto, Yoshihiro Nishimura. less Molecules, 2020 Aug 30; 25(17). PMID: 32859106 Free PMC article. Review.
Phage Display Derived Monoclonal Antibodies: From Bench to Bedside. Mohamed A Alfaleh, Hashem O Alsaab, +4 authors, Anwar M Hashem. less Front Immunol, 2020 Sep 29; 11. PMID: 32983137 Free PMC article. Review.
Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1. Youqiong Ye, Xinwei Kuang, +20 authors, Xiang Chen. less Genome Med, 2020 Sep 30; 12(1). PMID: 32988398 Free PMC article.
TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals. Francesco Manfredi, Beatrice Claudia Cianciotti, +6 authors, Eliana Ruggiero. less Front Immunol, 2020 Oct 06; 11. PMID: 33013822 Free PMC article. Review.
Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy. Zhongjian Xie, Minhua Peng, +9 authors, Paras N Prasad. less Light Sci Appl, 2020 Oct 06; 9. PMID: 33014356 Free PMC article.
D Olive. Rev Malad Respir Actual, 2020 Oct 13; 12(2). PMID: 33042321 Free PMC article.
Monoclonal Antibodies in Cancer Therapy. David Zahavi, Louis Weiner. Antibodies (Basel), 2020 Jul 24; 9(3). PMID: 32698317 Free PMC article. Review.
Immune Checkpoints in Viral Infections. Huiming Cai, Ge Liu, +9 authors, Qinchang Zhu. less Viruses, 2020 Sep 25; 12(9). PMID: 32967229 Free PMC article. Review.
Advances in targeted therapy for esophageal cancer. Yan-Ming Yang, Pan Hong, +2 authors, Wen Wen Xu, Qing-Yu He, Bin Li. less Signal Transduct Target Ther, 2020 Oct 09; 5(1). PMID: 33028804 Free PMC article. Review.
Deconstructing tumor heterogeneity: the stromal perspective. Renee E Vickman, Douglas V Faget, +25 authors, Sheila A Stewart. less Oncotarget, 2020 Oct 23; 11(40). PMID: 33088423 Free PMC article.
Effectiveness of the combination of vascular targeted photodynamic therapy and anti-cytotoxic T-lymphocyte-associated antigen 4 in a preclinical mouse model of urothelial carcinoma. Renato B Corradi, Stephen LaRosa, +7 authors, Jonathan A Coleman. less Int J Urol, 2019 Jan 20; 26(3). PMID: 30659668 Free PMC article.
Near-Infrared Photoimmunotherapy Combined with CTLA4 Checkpoint Blockade in Syngeneic Mouse Cancer Models. Yasuhiro Maruoka, Aki Furusawa, +7 authors, Hisataka Kobayashi. less Vaccines (Basel), 2020 Sep 18; 8(3). PMID: 32937841 Free PMC article.
Computational Verification of Large Logical Models-Application to the Prediction of T Cell Response to Checkpoint Inhibitors. Céline Hernandez, Morgane Thomas-Chollier, Aurélien Naldi, Denis Thieffry. Front Physiol, 2020 Oct 27; 11. PMID: 33101049 Free PMC article.
RNA-electroporated T cells for cancer immunotherapy. Fernanda Pohl-Guimarães, Lan B Hoang-Minh, Duane A Mitchell. Oncoimmunology, 2020 Oct 27; 9(1). PMID: 33101771 Free PMC article. Review.
Pharmacogenomics for immunotherapy and immune-related cardiotoxicity. Jessica A Castrillon, Charis Eng, Feixiong Cheng. Hum Mol Genet, 2020 Jul 06; 29(R2). PMID: 32620943 Free PMC article. Review.
A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer. Dimitrios Korentzelos, Amanda M Clark, Alan Wells. Int J Mol Sci, 2020 Oct 08; 21(19). PMID: 33022920 Free PMC article. Review.
The Tumor and Host Immune Signature, and the Gut Microbiota as Predictive Biomarkers for Immune Checkpoint Inhibitor Response in Melanoma Patients. Katarzyna Tomela, Bernadeta Pietrzak, Marcin Schmidt, Andrzej Mackiewicz. Life (Basel), 2020 Oct 01; 10(10). PMID: 32992737 Free PMC article. Review.
Anti-PD1 and Anti-PDL1-Induced Hypophysitis: A Cohort Study of 17 Patients with Longitudinal Follow-Up. Manon Levy, Juliette Abeillon, +5 authors, Christine Cugnet-Anceau. less J Clin Med, 2020 Oct 18; 9(10). PMID: 33066179 Free PMC article.
Immune Activation in Patients with Locally Advanced Cervical Cancer Treated with Ipilimumab Following Definitive Chemoradiation (GOG-9929). Diane M Da Silva, Danielle M Enserro, +10 authors, W Martin Kast. less Clin Cancer Res, 2020 Aug 21; 26(21). PMID: 32816895 Free PMC article.
The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand? Rossana Franzin, Giuseppe Stefano Netti, +5 authors, Elena Ranieri. less Front Immunol, 2020 Nov 10; 11. PMID: 33162990 Free PMC article. Review.
Epithelial-Mesenchymal Transition: Role in Cancer Progression and the Perspectives of Antitumor Treatment. A V Gaponova, S Rodin, A A Mazina, P V Volchkov. Acta Naturae, 2020 Nov 12; 12(3). PMID: 33173593 Free PMC article.
Current Clinical Applications and Future Perspectives of Immune Checkpoint Inhibitors in Non-Hodgkin Lymphoma. John Apostolidis, Ayman Sayyed, +2 authors, Hani Al Hashmi. less J Immunol Res, 2020 Nov 13; 2020. PMID: 33178841 Free PMC article. Review.
Overcoming Tumor-Induced Immune Suppression: From Relieving Inhibition to Providing Costimulation with T Cell Agonists. Dana A Emerson, William L Redmond. BioDrugs, 2018 Apr 11; 32(3). PMID: 29637478 Free PMC article. Review.
Cancer cell metabolic reprogramming: a keystone for the response to immunotherapy. Michaël Cerezo, Stéphane Rocchi. Cell Death Dis, 2020 Nov 13; 11(11). PMID: 33177494 Free PMC article. Review.
PD-1 Inhibitors: Do they have a Future in the Treatment of Glioblastoma? Mustafa Khasraw, David A Reardon, Michael Weller, John H Sampson. Clin Cancer Res, 2020 Jun 13; 26(20). PMID: 32527943 Free PMC article. Review.
Will Next-Generation Immunotherapy Overcome the Intrinsic Diversity and Low Immunogenicity of Sarcomas to Improve Clinical Benefit? Hui Yi Chew, Victor Chan, Fiona Simpson, Riccardo Dolcetti. Cancers (Basel), 2020 Nov 20; 12(11). PMID: 33207697 Free PMC article. Review.
The Angiopoietin-2 and TIE Pathway as a Therapeutic Target for Enhancing Antiangiogenic Therapy and Immunotherapy in Patients with Advanced Cancer. Alessandra Leong, Minah Kim. Int J Mol Sci, 2020 Nov 22; 21(22). PMID: 33217955 Free PMC article. Review.
Regulatory T Cells: From Discovery to Autoimmunity. Alexandra Kitz, Emily Singer, David Hafler. Cold Spring Harb Perspect Med, 2018 Jan 10; 8(12). PMID: 29311129 Free PMC article. Review.
Ipilimumab in prostate cancer. Nishith Singh, Ravi A Madan, James L Gulley. Expert Opin Biol Ther, 2012 Dec 26; 13(2). PMID: 23265575 Free PMC article. Review.
The clinical evidence for targeting human myeloid-derived suppressor cells in cancer patients. Richard P Tobin, Dana Davis, Kimberly R Jordan, Martin D McCarter. J Leukoc Biol, 2017 Feb 10; 102(2). PMID: 28179538 Free PMC article. Review.
Non-conventional Inhibitory CD4+Foxp3-PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity. Roberta Zappasodi, Sadna Budhu, +13 authors, Jedd D Wolchok. less Cancer Cell, 2018 Jun 13; 33(6). PMID: 29894689 Free PMC article. Highly Cited.
A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization. Miguel F Sanmamed, Lieping Chen. Cell, 2018 Oct 06; 175(2). PMID: 30290139 Free PMC article. Highly Cited. Review.
Molecular predictors of response to PD-1/PD-L1 inhibition in urothelial cancer. Viktoria Stühler, Jan Moritz Maas, +4 authors, Jens Bedke. less World J Urol, 2018 Oct 31; 37(9). PMID: 30374610 Review.
Combining PARP inhibition, radiation, and immunotherapy: A possible strategy to improve the treatment of cancer? Mathieu Césaire, Juliette Thariat, +3 authors, François Chevalier. less Int J Mol Sci, 2018 Nov 30; 19(12). PMID: 30487462 Free PMC article. Review.
The Era of Immune Checkpoint Therapy: From Cancer to Viral Infection-A Mini Comment on the 2018 Medicine Nobel Prize. Jia Liu, Wen Pan, Dongliang Yang. Virol Sin, 2018 Dec 21; 33(6). PMID: 30570713 Free PMC article.
Targeting Multiple Receptors to Increase Checkpoint Blockade Efficacy. David J Zahavi, Louis M Weiner. Int J Mol Sci, 2019 Jan 10; 20(1). PMID: 30621125 Free PMC article. Review.
Realizing the Clinical Potential of Immunogenic Cell Death in Cancer Chemotherapy and Radiotherapy. Bernardo L Rapoport, Ronald Anderson. Int J Mol Sci, 2019 Mar 01; 20(4). PMID: 30813267 Free PMC article. Highly Cited. Review.
RIG-I activating immunostimulatory RNA boosts the efficacy of anticancer vaccines and synergizes with immune checkpoint blockade. Simon Heidegger, Diana Kreppel, +10 authors, Hendrik Poeck. less EBioMedicine, 2019 Mar 11; 41. PMID: 30852164 Free PMC article.
Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review. Tatsuo Kanda, Taichiro Goto, +2 authors, Yosuke Hirotsu, Mitsuhiko Moriyama, Masao Omata. less Int J Mol Sci, 2019 Mar 21; 20(6). PMID: 30889843 Free PMC article. Highly Cited. Review.
＜Editors' Choice＞ Meddling with meddlers: curbing regulatory T cells and augmenting antitumor immunity. Vitaly Kochin, Hiroyoshi Nishikawa. Nagoya J Med Sci, 2019 Apr 10; 81(1). PMID: 30962651 Free PMC article. Review.
Clinical development of targeted and immune based anti-cancer therapies. N A Seebacher, A E Stacy, G M Porter, A M Merlot. J Exp Clin Cancer Res, 2019 Apr 13; 38(1). PMID: 30975211 Free PMC article. Review.
Autoimmune Endocrine Dysfunctions Associated with Cancer Immunotherapies. Silvia Martina Ferrari, Poupak Fallahi, +8 authors, Alessandro Antonelli. less Int J Mol Sci, 2019 May 30; 20(10). PMID: 31137683 Free PMC article. Review.
Optimizing radiotherapy with immune checkpoint blockade in hepatocellular carcinoma. Changhoon Choi, Gyu Sang Yoo, Won Kyung Cho, Hee Chul Park. World J Gastroenterol, 2019 Jun 07; 25(20). PMID: 31171886 Free PMC article. Review.
IgG based immunome analyses of breast cancer patients reveal underlying signaling pathways. István Gyurján, Sandra Rosskopf, +3 authors, Andreas Weinhäusel. less Oncotarget, 2019 Jun 14; 10(37). PMID: 31191821 Free PMC article.
Combination of CTLA-4 and PD-1 blockers for treatment of cancer. Anand Rotte. J Exp Clin Cancer Res, 2019 Jun 15; 38(1). PMID: 31196207 Free PMC article. Highly Cited. Review.
Genetic and genomic basis of the mismatch repair system involved in Lynch syndrome. Kazuo Tamura, Motohide Kaneda, +5 authors, Junko Tatsumi-Miyajima. less Int J Clin Oncol, 2019 Jul 06; 24(9). PMID: 31273487 Review.
[Interstitial nephritis]. Anna Laura Herzog, Kai Lopau. Internist (Berl), 2019 Jul 10; 60(8). PMID: 31286163
Can Allosteric Receptor-Protein Interactions in Receptor Complexes Be a Molecular Mechanism Involved in Cancer Immune Therapy? Dasiel O Borroto-Escuela, Kjell Fuxe. Front Endocrinol (Lausanne), 2019 Sep 05; 10. PMID: 31481934 Free PMC article.
HARNESSING THE IMMUNE RESPONSE: BASIC PRINCIPLES AND THERAPEUTIC APPLICATIONS. Abul K Abbas. Trans Am Clin Climatol Assoc, 2019 Sep 14; 130. PMID: 31516161 Free PMC article. Review.
Discovery Strategies to Maximize the Clinical Potential of T-Cell Engaging Antibodies for the Treatment of Solid Tumors. Vladimir Voynov, Paul J Adam, Andrew E Nixon, Justin M Scheer. Antibodies (Basel), 2020 Nov 22; 9(4). PMID: 33217946 Free PMC article. Review.
Comprehensive Evaluation of Immune-Checkpoint DNA Cancer Vaccines in a Rat Cholangiocarcinoma Model. Yi-Ru Pan, Chiao-En Wu, +4 authors, Chun-Nan Yeh. less Vaccines (Basel), 2020 Dec 02; 8(4). PMID: 33255375 Free PMC article.
Overcoming Immune Evasion in Melanoma. Kevinn Eddy, Suzie Chen. Int J Mol Sci, 2020 Dec 02; 21(23). PMID: 33256089 Free PMC article. Review.
Treatment Strategies and Metabolic Pathway Regulation in Urothelial Cell Carcinoma: A Comprehensive Review. Huang-Yu Yang, Chao-Yi Wu, Jia-Jin Chen, Tao-Han Lee. Int J Mol Sci, 2020 Dec 02; 21(23). PMID: 33256165 Free PMC article. Review.
Fifty Years of Witnessing Biomedical Science Developments. Manica Negahdaripour. Iran J Med Sci, 2020 Dec 08; 45(6). PMID: 33281257 Free PMC article.
Radiation and immunotherapy: emerging mechanisms of synergy. William G Breen, Konstantinos Leventakos, Haidong Dong, Kenneth W Merrell. J Thorac Dis, 2020 Dec 08; 12(11). PMID: 33282406 Free PMC article. Review.
Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy. Yuka Igarashi, Tetsuro Sasada. J Immunol Res, 2020 Dec 08; 2020. PMID: 33282961 Free PMC article. Review.
Activating the Antitumor Immune Response in Non-Hodgkin Lymphoma Using Immune Checkpoint Inhibitors. Maansi Joshi, Stephen M Ansell. J Immunol Res, 2020 Dec 10; 2020. PMID: 33294467 Free PMC article. Review.
Non-invasive biomarkers for monitoring the immunotherapeutic response to cancer. Sabah Nisar, Ajaz A Bhat, +8 authors, Mohammad Haris. less J Transl Med, 2020 Dec 11; 18(1). PMID: 33298096 Free PMC article. Review.
The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy. Qiyao Yang, Ningning Guo, +3 authors, Yi Zhou, Jiejian Chen, Qichun Wei, Min Han. less Acta Pharm Sin B, 2020 Dec 12; 10(11). PMID: 33304783 Free PMC article. Review.
Immune checkpoint inhibitor-associated myopathy: a clinicoseropathologically distinct myopathy. Shahar Shelly, James D Triplett, +4 authors, Teerin Liewluck. less Brain Commun, 2020 Dec 12; 2(2). PMID: 33305263 Free PMC article.
TGFβ biology in cancer progression and immunotherapy. Rik Derynck, Shannon J Turley, Rosemary J Akhurst. Nat Rev Clin Oncol, 2020 Jul 28; 18(1). PMID: 32710082 Review.
Intravenous injection of the oncolytic virus M1 awakens antitumor T cells and overcomes resistance to checkpoint blockade. Yang Liu, Jing Cai, +10 authors, Jiankai Liang. less Cell Death Dis, 2020 Dec 15; 11(12). PMID: 33311488 Free PMC article.
From the T-cell receptor to cancer therapy: an interview with Tak W. Mak. Tak W Mak. Cell Death Differ, 2020 Dec 19; 28(1). PMID: 33335286 Free PMC article.
Association of cytotoxic T lymphocyte-associated protein 4 gene -1772T/C polymorphism with gastric cancer risk: A prisma-compliant meta-analysis. Chenyi Zhuo, Tingzhuang Yi, +6 authors, Qianli Tang. less Medicine (Baltimore), 2020 Dec 18; 99(50). PMID: 33327303 Free PMC article. Systematic Review.
Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells. Silke Eisinger, Dhifaf Sarhan, +17 authors, Mikael C I Karlsson. less Proc Natl Acad Sci U S A, 2020 Nov 25; 117(50). PMID: 33229588 Free PMC article.
Cancer Immunotherapy and Application of Nanoparticles in Cancers Immunotherapy as the Delivery of Immunotherapeutic Agents and as the Immunomodulators. Tilahun Ayane Debele, Cheng-Fa Yeh, Wen-Pin Su. Cancers (Basel), 2020 Dec 19; 12(12). PMID: 33333816 Free PMC article. Review.
Activation of T helper cells in sentinel node predicts poor prognosis in oral squamous cell carcinoma. Åsa Kågedal, Eric Hjalmarsson, +7 authors, Lars Olaf Cardell. less Sci Rep, 2020 Dec 20; 10(1). PMID: 33339891 Free PMC article.
Central Nervous System Demyelination Associated With Immune Checkpoint Inhibitors: Review of the Literature. Marcos C B Oliveira, Marcelo H de Brito, Mateus M Simabukuro. Front Neurol, 2020 Dec 29; 11. PMID: 33362680 Free PMC article. Review.
Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy. Richard Lee Barrett, Ellen Puré. Elife, 2020 Dec 29; 9. PMID: 33370234 Free PMC article. Review.
Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule. Alexey Berezhnoy, Bradley J Sumrow, +16 authors, Paul A Moore. less Cell Rep Med, 2020 Dec 31; 1(9). PMID: 33377134 Free PMC article.
Running to Stand Still: Naive CD8+ T Cells Actively Maintain a Program of Quiescence. Taylah J Bennett, Vibha A V Udupa, Stephen J Turner. Int J Mol Sci, 2020 Dec 30; 21(24). PMID: 33371448 Free PMC article. Review.
Clinical Importance of CD200 Expression in Colorectal Liver Metastasis. Yasuko Matsuo, Masayuki Sho, +5 authors, Yosuke Iwasa. less Ann Surg Oncol, 2021 Jan 05; 28(9). PMID: 33393050
Checkpoint inhibitor immunotherapy in kidney cancer. Wenxin Xu, Michael B Atkins, David F McDermott. Nat Rev Urol, 2020 Feb 06; 17(3). PMID: 32020040 Review.
The immunology of renal cell carcinoma. C Marcela Díaz-Montero, Brian I Rini, James H Finke. Nat Rev Nephrol, 2020 Aug 01; 16(12). PMID: 32733094 Review.
Targeting TGFβ signal transduction for cancer therapy. Sijia Liu, Jiang Ren, Peter Ten Dijke. Signal Transduct Target Ther, 2021 Jan 09; 6(1). PMID: 33414388 Free PMC article. Review.
T cell antigen discovery via signaling and antigen-presenting bifunctional receptors. Alok V Joglekar, Michael T Leonard, +9 authors, David Baltimore. less Nat Methods, 2019 Feb 01; 16(2). PMID: 30700902 Free PMC article. Highly Cited.
Harnessing neoantigen specific CD4 T cells for cancer immunotherapy. Spencer E Brightman, Martin S Naradikian, Aaron M Miller, Stephen P Schoenberger. J Leukoc Biol, 2020 Mar 15; 107(4). PMID: 32170883 Free PMC article. Review.
Emerging Therapies in Pheochromocytoma and Paraganglioma: Immune Checkpoint Inhibitors in the Starting Blocks. Giuseppe Fanciulli, Sergio Di Molfetta, +7 authors, Nike Group. less J Clin Med, 2021 Jan 02; 10(1). PMID: 33383673 Free PMC article. Review.
A systematic review and network meta-analysis of single nucleotide polymorphisms associated with pancreatic cancer risk. Zhuo-Miao Ye, Li-Juan Li, +5 authors, You-Ming Tang. less Aging (Albany NY), 2020 Nov 24; 12(24). PMID: 33226370 Free PMC article. Systematic Review.
Development of an immune-related gene pairs index for the prognosis analysis of metastatic melanoma. Rong-Zhi Huang, Min Mao, +6 authors, Xu Li. less Sci Rep, 2021 Jan 15; 11(1). PMID: 33441929 Free PMC article.
TLRs as a Promise Target Along With Immune Checkpoint Against Gastric Cancer. Lin Cui, Xiuqing Wang, Dekai Zhang. Front Cell Dev Biol, 2021 Jan 21; 8. PMID: 33469538 Free PMC article. Review.
The Search for an Interesting Partner to Combine with PD-L1 Blockade in Mesothelioma: Focus on TIM-3 and LAG-3. Elly Marcq, Jonas R M Van Audenaerde, +5 authors, Evelien L J Smits. less Cancers (Basel), 2021 Jan 21; 13(2). PMID: 33466653 Free PMC article.
Rethinking immune checkpoint blockade: 'Beyond the T cell'. Xiuting Liu, Graham D Hogg, David G DeNardo. J Immunother Cancer, 2021 Jan 21; 9(1). PMID: 33468555 Free PMC article. Review.
Next-Generation Immunotherapies to Improve Anticancer Immunity. Yaoyao Shi, Katarzyna Tomczak, +3 authors, Cara Haymaker. less Front Pharmacol, 2021 Jan 29; 11. PMID: 33505304 Free PMC article. Review.
The Beneficial Role of Sunitinib in Tumor Immune Surveillance by Regulating Tumor PD-L1. Hui Li, Xinwei Kuang, +16 authors, Xiang Chen. less Adv Sci (Weinh), 2021 Jan 30; 8(2). PMID: 33510997 Free PMC article.
Understanding and Targeting Human Cancer Regulatory T Cells to Improve Therapy. H Ryan Kolb, Nicholas Borcherding, Weizhou Zhang. Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523451
Immune Checkpoint Molecules-Inherited Variations as Markers for Cancer Risk. Marta Wagner, Monika Jasek, Lidia Karabon. Front Immunol, 2021 Feb 02; 11. PMID: 33519815 Free PMC article. Review.
Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance. Fang Wei, Dan Wang, +10 authors, Zhaoyang Zeng. less Cell Mol Life Sci, 2020 Jul 13; 78(1). PMID: 32654036 Review.
Improving the Efficacy of Liver Cancer Immunotherapy: The Power of Combined Preclinical and Clinical Studies. Gen-Sheng Feng, Kaisa L Hanley, Yan Liang, Xiaoxue Lin. Hepatology, 2020 Jul 28; 73 Suppl 1. PMID: 32715491 Free PMC article. Review.
Mesenchymal traits at the convergence of tumor-intrinsic and -extrinsic mechanisms of resistance to immune checkpoint blockers. Paola Trono, Antonella Sistigu, +2 authors, Belinda Palermo, Gennaro Ciliberto, Paola Nisticò. less Emerg Top Life Sci, 2017 Dec 12; 1(5). PMID: 33525801 Free PMC article.
Preclinical Models of Pancreatic Ductal Adenocarcinoma and Their Utility in Immunotherapy Studies. Thao N D Pham, Mario A Shields, +6 authors, Hidayatullah G Munshi. less Cancers (Basel), 2021 Jan 29; 13(3). PMID: 33503832 Free PMC article. Review.
PI3Kδ inhibition modulates regulatory and effector T-cell differentiation and function in chronic lymphocytic leukemia. Bola S Hanna, Philipp M Roessner, +6 authors, Martina Seiffert. less Leukemia, 2018 Dec 24; 33(6). PMID: 30573773
Clinical and pathologic features associated with PD-L1 (SP142) expression in stromal tumor-infiltrating immune cells of triple-negative breast carcinoma. Raza Syed Hoda, Edi Brogi, +10 authors, Hannah Yong Wen. less Mod Pathol, 2020 Jul 03; 33(11). PMID: 32612248 Free PMC article.
;. PMID: 33563927
The science and medicine of human immunology. Bali Pulendran, Mark M Davis. Science, 2020 Sep 26; 369(6511). PMID: 32973003 Free PMC article. Review.
Combinations using checkpoint blockade to overcome resistance. Stefania Morganti, Giuseppe Curigliano. Ecancermedicalscience, 2021 Feb 13; 14. PMID: 33574893 Free PMC article. Review.
Lysophosphatidic Acid Is an Inflammatory Lipid Exploited by Cancers for Immune Evasion via Mechanisms Similar and Distinct From CTLA-4 and PD-1. Divij Mathew, Raul M Torres. Front Immunol, 2021 Feb 16; 11. PMID: 33584637 Free PMC article. Review.
Designing and Immunomodulating Multiresponsive Nanomaterial for Cancer Theranostics. Amreen Khan, Faith Dias, +2 authors, Suditi Neekhra, Barkha Singh, Rohit Srivastava. less Front Chem, 2021 Feb 16; 8. PMID: 33585406 Free PMC article. Review.
Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling. Juanjuan Yuan, Ting Cai, +14 authors, Wei Yang. less Protein Cell, 2021 Feb 20; 12(4). PMID: 33606190 Free PMC article.
A T cell repertoire timestamp is at the core of responsiveness to CTLA-4 blockade. Hagit Philip, Tom Snir, +3 authors, Sol Efroni. less iScience, 2021 Feb 20; 24(2). PMID: 33604527 Free PMC article.
Potential therapeutic targets in the tumor microenvironment of hepatocellular carcinoma: reversing the protumor effect of tumor-associated macrophages. Jingyi Zhou, Weiyu Wang, Qi Li. J Exp Clin Cancer Res, 2021 Feb 19; 40(1). PMID: 33596985 Free PMC article. Review.
An Immune Cell Signature Is Associated With Disease-Free Survival and Adjuvant Chemosensitivity of Patients With Resectable Gastric Cancer. Hongfei Yan, Yang Chen, +5 authors, Xiujuan Qu. less Front Immunol, 2021 Feb 23; 11. PMID: 33613554 Free PMC article.
Antigen folding improves loading efficiency and antitumor efficacy of PC7A nanoparticle vaccine. Jonathan Wilhelm, Manuel Quiñones-Pérez, +3 authors, Jian Wang, Xu Wang, Vijay S Basava, Jinming Gao. less J Control Release, 2020 Dec 11; 329. PMID: 33301836 Free PMC article.
Interferon γ and Its Important Roles in Promoting and Inhibiting Spontaneous and Therapeutic Cancer Immunity. Elise Alspach, Danielle M Lussier, Robert D Schreiber. Cold Spring Harb Perspect Biol, 2018 Apr 18; 11(3). PMID: 29661791 Free PMC article. Highly Cited. Review.
Immune checkpoint inhibitors: a narrative review of considerations for the anaesthesiologist. Alexandra L Lewis, Jamie Chaft, Monica Girotra, Gregory W Fischer. Br J Anaesth, 2020 Feb 03; 124(3). PMID: 32007241 Free PMC article. Review.
Immune checkpoint inhibitor-associated myocarditis: manifestations and mechanisms. Javid Moslehi, Andrew H Lichtman, +2 authors, Arlene H Sharpe, Lorenzo Galluzzi, Richard N Kitsis. less J Clin Invest, 2021 Mar 02; 131(5). PMID: 33645548 Free PMC article. Review.
Correlations Between Tumor Mutation Burden and Immunocyte Infiltration and Their Prognostic Value in Colon Cancer. Zhangjian Zhou, Xin Xie, +7 authors, Hao Zhang. less Front Genet, 2021 Mar 06; 12. PMID: 33664769 Free PMC article.
Nivolumab-induced hypophysitis leading to hypopituitarism and secondary empty sella syndrome in a patient with non-small cell lung cancer. Jeremy Chang, Jeffrey Tran, Dina Kamel, Arnab Basu. BMJ Case Rep, 2019 Mar 10; 12(3). PMID: 30850565 Free PMC article.
Novel oxidative stress-related prognostic biomarkers for melanoma associated with tumor metastasis. Xianpei Wu, Jinmin Zhao. Medicine (Baltimore), 2021 Mar 06; 100(8). PMID: 33663112 Free PMC article.
Immune Deregulation in Sepsis and Septic Shock: Reversing Immune Paralysis by Targeting PD-1/PD-L1 Pathway. Yuki Nakamori, Eun Jeong Park, Motomu Shimaoka. Front Immunol, 2021 Mar 09; 11. PMID: 33679715 Free PMC article. Review.
Generating tumor-selective conditionally active biologic anti-CTLA4 antibodies via protein-associated chemical switches. Hwai Wen Chang, Gerhard Frey, +4 authors, Jay M Short. less Proc Natl Acad Sci U S A, 2021 Feb 26; 118(9). PMID: 33627407 Free PMC article.
A Review of Monoclonal Antibody-Based Treatments in Non-small Cell Lung Cancer. Yunes Panahi, Amir Hossein Mohammadzadeh, +3 authors, Amirhossein Sahebkar. less Adv Exp Med Biol, 2021 Mar 17; 1286. PMID: 33725344 Review.
Prognostic Value of Deep Learning-Mediated Treatment Monitoring in Lung Cancer Patients Receiving Immunotherapy. Stefano Trebeschi, Zuhir Bodalal, +12 authors, Regina G H Beets-Tan. less Front Oncol, 2021 Mar 20; 11. PMID: 33738253 Free PMC article.
TIM-3 and TIGIT are possible immune checkpoint targets in patients with bladder cancer. Kyrollis Attalla, Adam M Farkas, +4 authors, John P Sfakianos. less Urol Oncol, 2020 Jul 16;. PMID: 32665122 Free PMC article. Review.
The Role of Immune Checkpoint Molecules for Relapse After Allogeneic Hematopoietic Cell Transplantation. Natalie Köhler, Dietrich Alexander Ruess, Rebecca Kesselring, Robert Zeiser. Front Immunol, 2021 Mar 23; 12. PMID: 33746972 Free PMC article. Review.
Harnessing Tumor Necrosis Factor Alpha to Achieve Effective Cancer Immunotherapy. María Florencia Mercogliano, Sofía Bruni, +2 authors, Roxana Schillaci. less Cancers (Basel), 2021 Feb 06; 13(3). PMID: 33540543 Free PMC article. Review.
Systemic adverse effects and toxicities associated with immunotherapy: A review. Asim Kichloo, Michael Albosta, +7 authors, Manidhar Lekkala. less World J Clin Oncol, 2021 Mar 27; 12(3). PMID: 33767971 Free PMC article. Review.
Pyroptosis: mechanisms and diseases. Pian Yu, Xu Zhang, +3 authors, Nian Liu, Ling Tang, Cong Peng, Xiang Chen. less Signal Transduct Target Ther, 2021 Mar 30; 6(1). PMID: 33776057 Free PMC article. Review.
A view on drug resistance in cancer. Neil Vasan, José Baselga, David M Hyman. Nature, 2019 Nov 15; 575(7782). PMID: 31723286 Free PMC article. Highly Cited. Review.
Integrative Analysis of the Expression of SIGLEC Family Members in Lung Adenocarcinoma via Data Mining. Haiyan Zhang, Yongfei Xie, +6 authors, Qing Yuan. less Front Oncol, 2021 Apr 03; 11. PMID: 33796453 Free PMC article.
Targeting the Tumor Microenvironment for Improving Therapeutic Effectiveness in Cancer Immunotherapy: Focusing on Immune Checkpoint Inhibitors and Combination Therapies. I-Tsu Chyuan, Ching-Liang Chu, Ping-Ning Hsu. Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33801815 Free PMC article. Review.
Emerging Trends for Radio-Immunotherapy in Rectal Cancer. Claudia Corrò, Valérie Dutoit, Thibaud Koessler. Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33803620 Free PMC article. Review.
Biological Heterogeneity of Chondrosarcoma: From (Epi) Genetics through Stemness and Deregulated Signaling to Immunophenotype. Agnieszka Zając, Sylwia K Król, Piotr Rutkowski, Anna M Czarnecka. Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33804155 Free PMC article. Review.
Immune Checkpoints Pathways in Head and Neck Squamous Cell Carcinoma. Florencia Veigas, Yamil D Mahmoud, +3 authors, María Romina Girotti. less Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33804419 Free PMC article. Review.
Specific Patterns of Blood ILCs in Metastatic Melanoma Patients and Their Modulations in Response to Immunotherapy. Louise Rethacker, Marie Roelens, +3 authors, Anne Caignard. less Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33810032 Free PMC article.
Cancer immunotherapies revisited: state of the art of conventional treatments and next-generation nanomedicines. Coral García-Fernández, Anna Saz, Cristina Fornaguera, Salvador Borrós. Cancer Gene Ther, 2021 Apr 11; 28(9). PMID: 33837365 Review.
Promising potential of [177Lu]Lu-DOTA-folate to enhance tumor response to immunotherapy-a preclinical study using a syngeneic breast cancer model. Patrycja Guzik, Klaudia Siwowska, +4 authors, Cristina Müller. less Eur J Nucl Med Mol Imaging, 2020 Oct 21; 48(4). PMID: 33078260 Free PMC article.
Engaging the Innate and Adaptive Antitumor Immune Response in Lymphoma. Clifford M Csizmar, Stephen M Ansell. Int J Mol Sci, 2021 Apr 04; 22(7). PMID: 33804869 Free PMC article. Review.
Mechanisms of Immune Evasion in Acute Lymphoblastic Leukemia. Agata Pastorczak, Krzysztof Domka, +2 authors, Klaudyna Fidyt, Martyna Poprzeczko, Malgorzata Firczuk. less Cancers (Basel), 2021 Apr 04; 13(7). PMID: 33810515 Free PMC article. Review.
Pancreatic Cancer: An Emphasis on Current Perspectives in Immunotherapy. Krishna Patel, Sohail Siraj, +3 authors, Riyaz Basha. less Crit Rev Oncog, 2019 Nov 05; 24(2). PMID: 31679206 Free PMC article. Review.
Identification of Tumor Antigens in the HLA Peptidome of Patient-derived Xenograft Tumors in Mouse. Nataly Mancette Rijensky, Netta R Blondheim Shraga, +11 authors, Arie Admon. less Mol Cell Proteomics, 2020 May 27; 19(8). PMID: 32451349 Free PMC article.
"Present and future of immunotherapy in Neuroendocrine Tumors". Manuela Albertelli, Andrea Dotto, +6 authors, Diego Ferone. less Rev Endocr Metab Disord, 2021 Apr 15; 22(3). PMID: 33851319 Free PMC article. Review.
Clinical Update on Checkpoint Inhibitor Therapy for Conjunctival and Eyelid Melanoma. Jonathan E Lu, Jessica R Chang, +2 authors, Jesse L Berry, Gino K In, Sandy Zhang-Nunes. less Int Ophthalmol Clin, 2020 Mar 25; 60(2). PMID: 32205655 Free PMC article.
Common germline variants of the human APOE gene modulate melanoma progression and survival. Benjamin N Ostendorf, Jana Bilanovic, +4 authors, Sohail F Tavazoie. less Nat Med, 2020 May 27; 26(7). PMID: 32451497 Free PMC article.
Metabolic barriers to cancer immunotherapy. Kristin DePeaux, Greg M Delgoffe. Nat Rev Immunol, 2021 May 01; 21(12). PMID: 33927375 Free PMC article. Review.
Epigenomics and immunotherapeutic advances in pediatric brain tumors. Malak Abedalthagafi, Nahla Mobark, May Al-Rashed, Musa AlHarbi. NPJ Precis Oncol, 2021 May 02; 5(1). PMID: 33931704 Free PMC article. Review.
Immunotherapy for Prostate Cancer. Nicholas J Venturini, Charles G Drake. Cold Spring Harb Perspect Med, 2018 Sep 12; 9(5). PMID: 30201787 Free PMC article. Review.
The 2018 Nobel Prize in Medicine for breakthroughs in targeting immune checkpoint inhibitors: a brief perspective. Adan Rios, Georgina To'a Salazar, Ningyan Zhang, Zhiqiang An. Antib Ther, 2019 Mar 14; 2(1). PMID: 33928220 Free PMC article.
The abscopal effect: a sense of DNA damage is in the air. Timothy P Lippert, Roger A Greenberg. J Clin Invest, 2021 May 04; 131(9). PMID: 33938453 Free PMC article. Review.
Integrated Analysis Reveals Prognostic Value and Immune Correlates of CD86 Expression in Lower Grade Glioma. Huaide Qiu, Wei Tian, +5 authors, Jianan Li. less Front Oncol, 2021 May 07; 11. PMID: 33954112 Free PMC article.
Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment. Naixue Yang, Fansen Ji, +4 authors, Xun Lan. less NPJ Precis Oncol, 2021 May 09; 5(1). PMID: 33963274 Free PMC article.
Biological bases of cancer immunotherapy. Maryanne M Gonzales Carazas, Joseph A Pinto, Fanny L Casado. Expert Rev Mol Med, 2021 Mar 26; 23. PMID: 33762030 Free PMC article.
LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy. Naveen Sharma, Oluwatomisin T Atolagbe, Zhongqi Ge, James P Allison. J Exp Med, 2021 May 12; 218(7). PMID: 33974041 Free PMC article.
Emerging therapeutic targets for sepsis. Elizabeth W Tindal, Brandon E Armstead, +2 authors, Sean F Monaghan, Daithi S Heffernan, Alfred Ayala. less Expert Opin Ther Targets, 2021 Mar 02; 25(3). PMID: 33641552 Free PMC article. Review.
Role of Immune Checkpoint Inhibitors in Cervical Cancer: From Preclinical to Clinical Data. Simona Duranti, Antonella Pietragalla, +4 authors, Domenica Lorusso. less Cancers (Basel), 2021 May 01; 13(9). PMID: 33925884 Free PMC article. Review.
Terminal Epitope-Dependent Branch Preference of Siglecs Toward N-Glycans. Shuaishuai Wang, Congcong Chen, +3 authors, Minhui Guan, Ding Liu, Xiu-Feng Wan, Lei Li. less Front Mol Biosci, 2021 May 18; 8. PMID: 33996901 Free PMC article.
Local Depletion of Immune Checkpoint Ligand CTLA4 Expressing Cells in Tumor Beds Enhances Antitumor Host Immunity. Ryuhei Okada, Takuya Kato, +4 authors, Hisataka Kobayashi. less Adv Ther (Weinh), 2021 May 18; 4(5). PMID: 33997271 Free PMC article.
Mechanisms and Management of Immune Checkpoint Inhibitor-Related Cardiac Adverse Events. Hiroshi Kadowaki, Hiroshi Akazawa, Junichi Ishida, Issei Komuro. JMA J, 2021 May 18; 4(2). PMID: 33997442 Free PMC article. Review.
Identification of CTLA-4-Positive Cells in the Human Tonsil. Markus Tiemann, Dmitri Atiakshin, Vera Samoilova, Igor Buchwalow. Cells, 2021 May 01; 10(5). PMID: 33925389 Free PMC article.
Targeting Epigenetics to Cure HIV-1: Lessons From (and for) Cancer Treatment. J Peter Svensson. Front Cell Infect Microbiol, 2021 May 25; 11. PMID: 34026665 Free PMC article. Review.
CTLA-4 +49 A/G Polymorphism and the Risk of Lung Cancer: a Meta-analysis. Zhengliang Wei, Shaoqin Zhang, Jian Hu. Zhongguo Fei Ai Za Zhi, 2021 Apr 06; 24(3). PMID: 33819967 Free PMC article. Systematic Review.
Nanobodies in cancer. Elisha R Verhaar, Andrew W Woodham, Hidde L Ploegh. Semin Immunol, 2020 Dec 05; 52. PMID: 33272897 Free PMC article. Review.
Modulating T Follicular Cells In Vivo Enhances Antigen-Specific Humoral Immunity. Jose D Pagan, Hera Vlamakis, +2 authors, Anthony Gaca, Ramnik J Xavier, Robert M Anthony. less J Immunol, 2021 May 21; 206(11). PMID: 34011521 Free PMC article.
Immunotherapy for Glioblastoma: Current Progress and Challenges. Miranda W Yu, Daniela F Quail. Front Immunol, 2021 Jun 01; 12. PMID: 34054867 Free PMC article. Review.
The landscape of tumors-infiltrate immune cells in papillary thyroid carcinoma and its prognostic value. Yanyi Huang, Tao Yi, +3 authors, Yushu Liu, Mengyun Yan, Xinli Peng, Yunxia Lv. less PeerJ, 2021 Jun 01; 9. PMID: 34055497 Free PMC article.
Cripto-1 as a Potential Target of Cancer Stem Cells for Immunotherapy. Hiroko Ishii, Said M Afify, +2 authors, Ghmkin Hassan, David S Salomon, Masaharu Seno. less Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34065315 Free PMC article. Review.
Acute Myeloid Leukemia: Is It T Time? Meriem Ben Khoud, Tiziano Ingegnere, +2 authors, Bruno Quesnel, Suman Mitra, Carine Brinster. less Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34069204 Free PMC article. Review.
Immune Checkpoint Inhibition for Triple-Negative Breast Cancer: Current Landscape and Future Perspectives. Huimei Yi, Ying Li, +3 authors, Yuan Tan, Shujun Fu, Faqing Tang, Xiyun Deng. less Front Oncol, 2021 Jun 08; 11. PMID: 34094935 Free PMC article. Review.
CRISPR/Cas9 Gene-Editing in Cancer Immunotherapy: Promoting the Present Revolution in Cancer Therapy and Exploring More. Xuejin Ou, Qizhi Ma, +2 authors, Wei Yin, Xuelei Ma, Zhiyao He. less Front Cell Dev Biol, 2021 Jun 08; 9. PMID: 34095145 Free PMC article. Review.
Reprogramming the anti-tumor immune response via CRISPR genetic and epigenetic editing. Eric Alves, Shahama Taifour, +4 authors, Pilar Blancafort. less Mol Ther Methods Clin Dev, 2021 Jun 08; 21. PMID: 34095343 Free PMC article. Review.
Durvalumab Plus Tremelimumab in Solid Tumors: A Systematic Review. Caterina Arru, Maria Rosaria De Miglio, +4 authors, Panagiotis Paliogiannis. less Adv Ther, 2021 Jun 10; 38(7). PMID: 34105088 Free PMC article. Systematic Review.
Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review. Kyoko Oura, Asahiro Morishita, Joji Tani, Tsutomu Masaki. Int J Mol Sci, 2021 Jun 03; 22(11). PMID: 34071550 Free PMC article. Review.
Mechanism-based treatment of cancer with immune checkpoint inhibitor therapies. Yara Abdou, Manu Pandey, +3 authors, Marc S Ernstoff. less Br J Clin Pharmacol, 2020 Apr 24; 86(9). PMID: 32323342 Free PMC article. Review.
The Immunology of Hormone Receptor Positive Breast Cancer. Jonathan Goldberg, Ricardo G Pastorello, +9 authors, Jennifer L Guerriero. less Front Immunol, 2021 Jun 18; 12. PMID: 34135901 Free PMC article. Review.
Cancer-associated fibroblasts: key determinants of tumor immunity and immunotherapy. Richard Barrett, Ellen Puré. Curr Opin Immunol, 2020 May 14; 64. PMID: 32402828 Free PMC article. Review.
Genetic Alterations in Gliomas Remodel the Tumor Immune Microenvironment and Impact Immune-Mediated Therapies. Maria B Garcia-Fabiani, Santiago Haase, +15 authors, Maria G Castro. less Front Oncol, 2021 Jun 26; 11. PMID: 34168976 Free PMC article. Review.
Targeting the extracellular matrix for immunomodulation: applications in drug delivery and cell therapies. Samira Aghlara-Fotovat, Amanda Nash, +2 authors, Boram Kim, Robert Krencik, Omid Veiseh. less Drug Deliv Transl Res, 2021 Jun 28; 11(6). PMID: 34176099 Review.
PTPN3 is a potential target for a new cancer immunotherapy that has a dual effect of T cell activation and direct cancer inhibition in lung neuroendocrine tumor. Satoko Koga, Hideya Onishi, +11 authors, Masafumi Nakamura. less Transl Oncol, 2021 Jun 17; 14(9). PMID: 34134073 Free PMC article.
Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers. Angela Tata, Garvin Dodard, +5 authors, Laurent Brossay. less Oncoimmunology, 2021 Jul 01; 10(1). PMID: 34188973 Free PMC article.
Modelling the interplay between the CD4[Formula: see text]/CD8[Formula: see text] T-cell ratio and the expression of MHC-I in tumours. Christian John Hurry, Alexander Mozeika, Alessia Annibale. J Math Biol, 2021 Jun 19; 83(1). PMID: 34143314 Free PMC article.
Metabolic Reprogramming of Colorectal Cancer Cells and the Microenvironment: Implication for Therapy. Miljana Nenkov, Yunxia Ma, Nikolaus Gaßler, Yuan Chen. Int J Mol Sci, 2021 Jul 03; 22(12). PMID: 34200820 Free PMC article. Review.
The Evolution of Cancer Immunotherapy. Meshaal Khan, Ajay V Maker, Shikha Jain. Vaccines (Basel), 2021 Jul 03; 9(6). PMID: 34200997 Free PMC article. Review.
Virtual Evolution of HVEM Segment for Checkpoint Inhibitor Discovery. Mingjia Yu, Huimin Zhao, +2 authors, Yuhui Miao, Shi-Zhong Luo, Song Xue. less Int J Mol Sci, 2021 Jul 03; 22(12). PMID: 34205742 Free PMC article.
Applications and analytical tools of cell communication based on ligand-receptor interactions at single cell level. Fen Ma, Siwei Zhang, +3 authors, Lianhao Song, Bozhi Wang, Lanlan Wei, Fengmin Zhang. less Cell Biosci, 2021 Jul 05; 11(1). PMID: 34217372 Free PMC article. Review.
MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It. Elena Shklovskaya, Helen Rizos. Int J Mol Sci, 2021 Jul 03; 22(13). PMID: 34201655 Free PMC article. Review.
The Natural History of T Cell Metabolism. Michel Y Braun. Int J Mol Sci, 2021 Jul 03; 22(13). PMID: 34202553 Free PMC article. Review.
The mechanisms of action of Plasmodium infection against cancer. Xiaoping Chen, Li Qin, Wen Hu, Dickson Adah. Cell Commun Signal, 2021 Jul 11; 19(1). PMID: 34243757 Free PMC article. Review.
FOXA1 overexpression suppresses interferon signaling and immune response in cancer. Yundong He, Liguo Wang, +26 authors, Haojie Huang. less J Clin Invest, 2021 Jun 09; 131(14). PMID: 34101624 Free PMC article.
Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity. Itziar Ibarlucea-Benitez, Polina Weitzenfeld, Patrick Smith, Jeffrey V Ravetch. Proc Natl Acad Sci U S A, 2021 Jun 23; 118(26). PMID: 34155121 Free PMC article.
The KrasG12D;Trp53fl/fl murine model of undifferentiated pleomorphic sarcoma is macrophage dense, lymphocyte poor, and resistant to immune checkpoint blockade. Karys M Hildebrand, Arvind K Singla, +9 authors, Michael J Monument. less PLoS One, 2021 Jul 10; 16(7). PMID: 34242269 Free PMC article.
The knowns & unknowns of pulmonary toxicity following immune checkpoint inhibitor therapies: a narrative review. Alistair R Miller, Renee Manser. Transl Lung Cancer Res, 2021 Jul 24; 10(6). PMID: 34295675 Free PMC article. Review.
Immunotherapy and Vaccination in Surgically Resectable Non-Small Cell Lung Cancer (NSCLC). Li-Chung Chiu, Shu-Min Lin, +3 authors, Ping-Chih Hsu. less Vaccines (Basel), 2021 Jul 03; 9(7). PMID: 34201650 Free PMC article. Review.
Senescence and Aging: Does It Impact Cancer Immunotherapies? Damien Maggiorani, Christian Beauséjour. Cells, 2021 Jul 03; 10(7). PMID: 34206425 Free PMC article. Review.
Immune-related toxicities of checkpoint inhibitors: mechanisms and mitigation strategies. Ryan J Sullivan, Jeffrey S Weber. Nat Rev Drug Discov, 2021 Jul 29;. PMID: 34316029 Review.
Cancer-Associated Fibroblasts: Implications for Cancer Therapy. Ana Maia, Stefan Wiemann. Cancers (Basel), 2021 Jul 25; 13(14). PMID: 34298736 Free PMC article. Review.
Submicron particle docetaxel intratumoral injection in combination with anti-mCTLA-4 into 4T1-Luc orthotopic implants reduces primary tumor and metastatic pulmonary lesions. Holly Maulhardt, Alyson Marin, Holly Hesseltine, Gere diZerega. Med Oncol, 2021 Aug 01; 38(9). PMID: 34331595 Free PMC article.
IDO Inhibition Facilitates Antitumor Immunity of Vγ9Vδ2 T Cells in Triple-Negative Breast Cancer. Peng Li, Ruan Wu, +8 authors, Yunfei Gao. less Front Oncol, 2021 Aug 13; 11. PMID: 34381711 Free PMC article.
Adoptive cellular therapy in solid tumor malignancies: review of the literature and challenges ahead. Kedar Kirtane, Hany Elmariah, Christine H Chung, Daniel Abate-Daga. J Immunother Cancer, 2021 Jul 25; 9(7). PMID: 34301811 Free PMC article. Review.
Expression of Immune Checkpoint Receptors in Placentae With Infectious and Non-Infectious Chronic Villitis. Maryam Shahi, Ricardo Mamber Czeresnia, +3 authors, Elizabeth Ann L Enninga. less Front Immunol, 2021 Aug 17; 12. PMID: 34394102 Free PMC article.
Immune PET Imaging. Osigbemhe Iyalomhe, Michael D Farwell. Radiol Clin North Am, 2021 Aug 17; 59(5). PMID: 34392924 Free PMC article. Review.
Melanoma models for the next generation of therapies. E Elizabeth Patton, Kristen L Mueller, +33 authors, Glenn Merlino. less Cancer Cell, 2021 Feb 06; 39(5). PMID: 33545064 Free PMC article. Review.
sCD28, sCD80, sCTLA-4, and sBTLA Are Promising Markers in Diagnostic and Therapeutic Approaches for Aseptic Loosening and Periprosthetic Joint Infection. Jil M Jubel, Thomas M Randau, +6 authors, Frank A Schildberg. less Front Immunol, 2021 Aug 24; 12. PMID: 34421900 Free PMC article.
Stem cell fate in cancer growth, progression and therapy resistance. Nikki K Lytle, Alison G Barber, Tannishtha Reya. Nat Rev Cancer, 2018 Sep 20; 18(11). PMID: 30228301 Free PMC article. Highly Cited. Review.
The Prognostic Value of the Lymph Node in Oesophageal Adenocarcinoma; Incorporating Clinicopathological and Immunological Profiling. Noel E Donlon, Maria Davern, +13 authors, Joanne Lysaght. less Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439160 Free PMC article.
Epigenetic Regulation of Immunotherapy Response in Triple-Negative Breast Cancer. Pere Llinàs-Arias, Sandra Íñiguez-Muñoz, +6 authors, Diego M Marzese. less Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439290 Free PMC article. Review.
The State of Immunotherapy in Hepatobiliary Cancers. Farhan Z Ilyas, Joal D Beane, Timothy M Pawlik. Cells, 2021 Aug 28; 10(8). PMID: 34440865 Free PMC article. Review.
T-Cell Responses in Merkel Cell Carcinoma: Implications for Improved Immune Checkpoint Blockade and Other Therapeutic Options. Laura Gehrcken, Tatjana Sauerer, Niels Schaft, Jan Dörrie. Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445385 Free PMC article. Review.
Germline genetic contribution to the immune landscape of cancer. Rosalyn W Sayaman, Mohamad Saad, +23 authors, Davide Bedognetti. less Immunity, 2021 Feb 11; 54(2). PMID: 33567262 Free PMC article.
The Challenge of ICIs Resistance in Solid Tumours: Could Microbiota and Its Diversity Be Our Secret Weapon? Michela Roberto, Catia Carconi, +4 authors, Paolo Marchetti. less Front Immunol, 2021 Sep 08; 12. PMID: 34489956 Free PMC article. Review.
Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune Responses. Allan Scarpitta, Ulrich T Hacker, +2 authors, Hildegard Büning, Olivier Boyer, Sahil Adriouch. less Front Oncol, 2021 Sep 08; 11. PMID: 34490126 Free PMC article. Review.
The Role of Oncogenes and Redox Signaling in the Regulation of PD-L1 in Cancer. Christophe Glorieux, Xiaojun Xia, Peng Huang. Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503236 Free PMC article. Review.
Immunotherapeutic Strategies for Canine Lymphoma: Changing the Odds Against Non-Hodgkin Lymphoma. Joana N R Dias, Ana S André, +3 authors, Frederico Aires-da-Silva. less Front Vet Sci, 2021 Sep 14; 8. PMID: 34513964 Free PMC article. Review.
Advanced therapeutic modalities in hepatocellular carcinoma: Novel insights. Bahare Shokoohian, Babak Negahdari, +7 authors, Massoud Vosough. less J Cell Mol Med, 2021 Aug 24; 25(18). PMID: 34423899 Free PMC article. Review.
CTLA-4 Synergizes With PD1/PD-L1 in the Inhibitory Tumor Microenvironment of Intrahepatic Cholangiocarcinoma. Xiao-Jun Guo, Jia-Cheng Lu, +17 authors, Xiao-Yong Huang. less Front Immunol, 2021 Sep 17; 12. PMID: 34526987 Free PMC article.
Moving Immune Therapy Forward Targeting TME. Kayla F Goliwas, Jessy S Deshane, Craig A Elmets, Mohammad Athar. Physiol Rev, 2020 Aug 14; 101(2). PMID: 32790578 Free PMC article. Review.
Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer. Yong-Bo Kang, Yue Cai. World J Gastroenterol, 2021 Sep 21; 27(32). PMID: 34539138 Free PMC article. Review.
Immune escape mechanisms and immunotherapy of urothelial bladder cancer. Zhao Yang, Yinyan Xu, +16 authors, Changyuan Yu. less J Clin Transl Res, 2021 Sep 21; 7(4). PMID: 34541363 Free PMC article. Review.
Development of preclinical and clinical models for immune-related adverse events following checkpoint immunotherapy: a perspective from SITC and AACR. Nicholas L Bayless, Jeffrey A Bluestone, +8 authors, Theresa L Walunas. less J Immunother Cancer, 2021 Sep 05; 9(9). PMID: 34479924 Free PMC article. Review.
The Status of Adjuvant and Neoadjuvant Melanoma Therapy, New Developments and Upcoming Challenges. Henner Stege, Maximilian Haist, +5 authors, Stephan Grabbe. less Target Oncol, 2021 Sep 24; 16(5). PMID: 34554353 Free PMC article. Review.
Prognostic and therapeutic TILs of cervical cancer-Current advances and future perspectives. Ying Tang, Anne X J Zhang, +2 authors, Guangyu Chen, Yanheng Wu, Wenyi Gu. less Mol Ther Oncolytics, 2021 Sep 24; 22. PMID: 34553029 Free PMC article. Review.
CD47-targeting antibodies as a novel therapeutic strategy in hematologic malignancies. Jennifer Sun, Yixuan Chen, +3 authors, Abdel Kareem Azab. less Leuk Res Rep, 2021 Sep 30; 16. PMID: 34584838 Free PMC article. Review.
Epitranscriptomic Approach: To Improve the Efficacy of ICB Therapy by Co-Targeting Intracellular Checkpoint CISH. Sunil Kumar, Parth Sarthi, +4 authors, Yong-Soo Bae. less Cells, 2021 Sep 29; 10(9). PMID: 34571899 Free PMC article. Review.
Inhibiting the Unconventionals: Importance of Immune Checkpoint Receptors in γδ T, MAIT, and NKT Cells. Elisa Catafal-Tardos, Maria Virginia Baglioni, Vasileios Bekiaris. Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572874 Free PMC article. Review.
Targeting the spectrum of immune checkpoints in prostate cancer. Laura A Sena, Samuel R Denmeade, Emmanuel S Antonarakis. Expert Rev Clin Pharmacol, 2021 Jul 16; 14(10). PMID: 34263692 Free PMC article. Review.
Immune checkpoints and immunotherapy in non-small cell lung cancer: Novel study progression, challenges and solutions. Lin-Rui Ma, Jia-Xin Li, +5 authors, Pei-Yu Yan. less Oncol Lett, 2021 Oct 02; 22(5). PMID: 34594428 Free PMC article. Review.
Metabolic Modifications, Inflammation, and Cancer Immunotherapy. Sihao Zheng, Qibin Song, Pingfeng Zhang. Front Oncol, 2021 Oct 12; 11. PMID: 34631531 Free PMC article. Review.
A mouse model for the study of anti-tumor T cell responses in Kras-driven lung adenocarcinoma. Brittany Fitzgerald, Kelli A Connolly, +7 authors, Nikhil S Joshi. less Cell Rep Methods, 2021 Oct 12; 1(5). PMID: 34632444 Free PMC article.
Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer. Fernanda G Kugeratski, Kathleen M McAndrews, Raghu Kalluri. Endocrinology, 2021 Jan 08; 162(3). PMID: 33411885 Free PMC article. Review.
Cardiac Toxicity Associated with Cancer Immunotherapy and Biological Drugs. Andrea Montisci, Maria Teresa Vietri, +3 authors, Claudio Napoli. less Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638281 Free PMC article. Review.
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth. R K Subbarao Malireddi, Rajendra Karki, +4 authors, Thirumala-Devi Kanneganti.

BioKDE: Biomedical Knowledge Discovery Engine

Abstract

Other Links