Journal Article
. 1997 Mar; 275(5307):1787-90.
doi: 10.1126/science.275.5307.1787.

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

P J Morin 1 A B Sparks  V Korinek  N Barker  H Clevers  B Vogelstein  K W Kinzler  
Affiliations
  • PMID: 9065402
  •     1302 citations

Abstract

Inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene initiates colorectal neoplasia. One of the biochemical activities associated with the APC protein is down-regulation of transcriptional activation mediated by beta-catenin and T cell transcription factor 4 (Tcf-4). The protein products of mutant APC genes present in colorectal tumors were found to be defective in this activity. Furthermore, colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites. These results indicate that regulation of beta-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or beta-catenin.

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EMBO J, 2000 May 16; 19(10). PMID: 10811618    Free PMC article.
Nuclear translocation of beta-catenin in colorectal cancer.
M Kobayashi, T Honma, +4 authors, H Asakura.
Br J Cancer, 2000 May 19; 82(10). PMID: 10817505    Free PMC article.
Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin.
J Zhurinsky, M Shtutman, A Ben-Ze'ev.
Mol Cell Biol, 2000 May 29; 20(12). PMID: 10825188    Free PMC article.
gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.
F T Kolligs, B Kolligs, +4 authors, E R Fearon.
Genes Dev, 2000 Jun 03; 14(11). PMID: 10837025    Free PMC article.
Somatic mutations of the APC gene in primary breast cancers.
K Furuuchi, M Tada, +6 authors, T Moriuchi.
Am J Pathol, 2000 Jun 15; 156(6). PMID: 10854222    Free PMC article.
Isolation and characterization of human NBL4, a gene involved in the beta-catenin/tcf signaling pathway.
H Ishiguro, Y Furukawa, +9 authors, Y Nakamura.
Jpn J Cancer Res, 2000 Jun 30; 91(6). PMID: 10874211    Free PMC article.
Localization of multiple melanoma tumor-suppressor genes on chromosome 11 by use of homozygosity mapping-of-deletions analysis.
E K Goldberg, J M Glendening, +7 authors, J W Fountain.
Am J Hum Genet, 2000 Jul 06; 67(2). PMID: 10877980    Free PMC article.
Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein.
K Tago, T Nakamura, +8 authors, T Akiyama.
Genes Dev, 2000 Jul 18; 14(14). PMID: 10898789    Free PMC article.
Highly Cited.
Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients.
D T Dang, K E Bachman, +3 authors, V W Yang.
FEBS Lett, 2000 Jul 29; 476(3). PMID: 10913614    Free PMC article.
Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis.
L K Su, C J Barnes, +3 authors, G Steinbach.
Am J Hum Genet, 2000 Aug 05; 67(3). PMID: 10924409    Free PMC article.
Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis.
T J Koh, C J Bulitta, +3 authors, T C Wang.
J Clin Invest, 2000 Aug 23; 106(4). PMID: 10953028    Free PMC article.
Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator.
A N Billin, H Thirlwell, D E Ayer.
Mol Cell Biol, 2000 Aug 25; 20(18). PMID: 10958684    Free PMC article.
More frequent beta-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated rats.
T Tsukamoto, H Tanaka, +4 authors, M Tatematsu.
Jpn J Cancer Res, 2000 Aug 31; 91(8). PMID: 10965019    Free PMC article.
Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis.
H C Hsu, Y M Jeng, +3 authors, S Y Peng.
Am J Pathol, 2000 Sep 12; 157(3). PMID: 10980116    Free PMC article.
Beta-catenin, an inducer of uncontrolled cell proliferation and migration in malignancies, is localized in the cytoplasm of vascular endothelium during neovascularization after myocardial infarction.
W M Blankesteijn, M E van Gijn, +2 authors, J F Smits.
Am J Pathol, 2000 Sep 12; 157(3). PMID: 10980127    Free PMC article.
The molecular genetics of colorectal cancer.
V W Yang.
Curr Gastroenterol Rep, 2000 Sep 12; 1(5). PMID: 10980985
Review.
The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling.
M Umbhauer, A Djiane, +4 authors, D L Shi.
EMBO J, 2000 Sep 16; 19(18). PMID: 10990458    Free PMC article.
Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy.
S Haq, G Choukroun, +9 authors, T Force.
J Cell Biol, 2000 Oct 06; 151(1). PMID: 11018058    Free PMC article.
Highly Cited.
Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation.
T Kirchner, T Brabletz.
Am J Pathol, 2000 Oct 06; 157(4). PMID: 11021815    Free PMC article.
Changes in E-cadherin associated with cytoplasmic molecules in well and poorly differentiated endometrial cancer.
S Miyamoto, H Baba, +4 authors, T Saito.
Br J Cancer, 2000 Oct 12; 83(9). PMID: 11027430    Free PMC article.
Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators.
K Kim, K M Pang, M Evans, E D Hay.
Mol Biol Cell, 2000 Oct 12; 11(10). PMID: 11029052    Free PMC article.
Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin.
M P Playford, D Bicknell, W F Bodmer, V M Macaulay.
Proc Natl Acad Sci U S A, 2000 Oct 18; 97(22). PMID: 11035789    Free PMC article.
Molecular pathogenesis of oral squamous carcinoma.
H K Williams.
Mol Pathol, 2000 Oct 21; 53(4). PMID: 11040937    Free PMC article.
Review.
Regulation of beta -catenin transformation by the p300 transcriptional coactivator.
Y Sun, F T Kolligs, +3 authors, G J Nabel.
Proc Natl Acad Sci U S A, 2000 Oct 26; 97(23). PMID: 11050151    Free PMC article.
Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein.
F Zhang, R L White, K L Neufeld.
Proc Natl Acad Sci U S A, 2000 Oct 26; 97(23). PMID: 11050185    Free PMC article.
Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer.
V J Wielenga, R van der Voort, +5 authors, S T Pals.
Am J Pathol, 2000 Nov 14; 157(5). PMID: 11073815    Free PMC article.
Sulindac and a cyclooxygenase-2 inhibitor, etodolac, increase APC mRNA in the colon of rats treated with azoxymethane.
Y Kishimoto, N Takata, +4 authors, J Hasegawa.
Gut, 2000 Nov 15; 47(6). PMID: 11076880    Free PMC article.
Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins.
J H Lipschutz, W Guo, +3 authors, K E Mostov.
Mol Biol Cell, 2000 Dec 05; 11(12). PMID: 11102522    Free PMC article.
Explaining differences in the severity of familial adenomatous polyposis and the search for modifier genes.
R Houlston, M Crabtree, +2 authors, I Tomlinson.
Gut, 2000 Dec 15; 48(1). PMID: 11115811    Free PMC article.
Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene.
L T Ziemer, D Pennica, A J Levine.
Mol Cell Biol, 2001 Jan 03; 21(2). PMID: 11134343    Free PMC article.
Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.
T E Meigs, T A Fields, D D McKee, P J Casey.
Proc Natl Acad Sci U S A, 2001 Jan 03; 98(2). PMID: 11136230    Free PMC article.
Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription.
S Chen, D C Guttridge, +5 authors, C Y Wang.
J Cell Biol, 2001 Jan 10; 152(1). PMID: 11149923    Free PMC article.
Highly Cited.
Gas6 induces growth, beta-catenin stabilization, and T-cell factor transcriptional activation in contact-inhibited C57 mammary cells.
S Goruppi, C Chiaruttini, +2 authors, C Schneider.
Mol Cell Biol, 2001 Jan 12; 21(3). PMID: 11154277    Free PMC article.
Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells.
A Reinacher-Schick, B M Gumbiner.
J Cell Biol, 2001 Feb 07; 152(3). PMID: 11157977    Free PMC article.
Specific down-regulation of an engineered human cyclin D1 promoter by a novel DNA-binding ligand in intact cells.
M E Laurance, D B Starr, +6 authors, A J Bardwell.
Nucleic Acids Res, 2001 Feb 13; 29(3). PMID: 11160886    Free PMC article.
beta- Catenin mutations and aberrant nuclear expression during endometrial tumorigenesis.
M Saegusa, M Hashimura, T Yoshida, I Okayasu.
Br J Cancer, 2001 Feb 13; 84(2). PMID: 11161379    Free PMC article.
Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells.
B H Park, B Vogelstein, K W Kinzler.
Proc Natl Acad Sci U S A, 2001 Feb 28; 98(5). PMID: 11226285    Free PMC article.
Beta-catenin dysregulation in thyroid neoplasms: down-regulation, aberrant nuclear expression, and CTNNB1 exon 3 mutations are markers for aggressive tumor phenotypes and poor prognosis.
G Garcia-Rostan, R L Camp, +3 authors, G Tallini.
Am J Pathol, 2001 Mar 10; 158(3). PMID: 11238046    Free PMC article.
Sporadic fundic gland polyps: common gastric polyps arising through activating mutations in the beta-catenin gene.
S C Abraham, B Nobukawa, +2 authors, T T Wu.
Am J Pathol, 2001 Mar 10; 158(3). PMID: 11238048    Free PMC article.
Frequent beta-catenin mutations in juvenile nasopharyngeal angiofibromas.
S C Abraham, E A Montgomery, F M Giardiello, T T Wu.
Am J Pathol, 2001 Mar 10; 158(3). PMID: 11238055    Free PMC article.
ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma.
G H Su, R Bansal, +4 authors, S E Kern.
Proc Natl Acad Sci U S A, 2001 Mar 15; 98(6). PMID: 11248065    Free PMC article.
EGF receptor/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye.
M Freeman, M Bienz.
EMBO Rep, 2001 Mar 22; 2(2). PMID: 11258709    Free PMC article.
All Tcf HMG box transcription factors interact with Groucho-related co-repressors.
H Brantjes, J Roose, M van De Wetering, H Clevers.
Nucleic Acids Res, 2001 Mar 27; 29(7). PMID: 11266540    Free PMC article.
Highly Cited.
Nuclear beta catenin expression is related to unfavourable outcome in oropharyngeal and hypopharyngeal squamous cell carcinoma.
M J Pukkila, J A Virtaniemi, +5 authors, V M Kosma.
J Clin Pathol, 2001 Mar 29; 54(1). PMID: 11271788    Free PMC article.
Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis.
T Kato, S Satoh, +8 authors, Y Furukawa.
Neoplasia, 2001 Apr 28; 3(1). PMID: 11326310    Free PMC article.
E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner.
C J Gottardi, E Wong, B M Gumbiner.
J Cell Biol, 2001 May 31; 153(5). PMID: 11381089    Free PMC article.
Highly Cited.
Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation.
S Persad, A A Troussard, +2 authors, S Dedhar.
J Cell Biol, 2001 Jun 13; 153(6). PMID: 11402061    Free PMC article.
The ubiquitin-proteasome pathway and proteasome inhibitors.
J Myung, K B Kim, C M Crews.
Med Res Rev, 2001 Jun 19; 21(4). PMID: 11410931    Free PMC article.
Highly Cited. Review.
Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene.
Y Wang, D Huso, +2 authors, J Nathans.
J Neurosci, 2001 Jun 27; 21(13). PMID: 11425903    Free PMC article.
Suppression of occurrence and advancement of beta-catenin-accumulated crypts, possible premalignant lesions of colon cancer, by selective cyclooxygenase-2 inhibitor, celecoxib.
Y Yamada, N Yoshimi, +6 authors, H Mori.
Jpn J Cancer Res, 2001 Jun 29; 92(6). PMID: 11429049    Free PMC article.
Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas.
M Ueda, R M Gemmill, +5 authors, H A Drabkin.
Br J Cancer, 2001 Jul 05; 85(1). PMID: 11437403    Free PMC article.
Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers.
Z Jin, G Tamura, +4 authors, T Motoyama.
Br J Cancer, 2001 Jul 05; 85(1). PMID: 11437404    Free PMC article.
Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour).
S Tejpar, C Li, +6 authors, B A Alman.
Br J Cancer, 2001 Jul 05; 85(1). PMID: 11437409    Free PMC article.
Reduced expression of plakoglobin correlates with adverse outcome in patients with neuroblastoma.
R Amitay, D Nass, +7 authors, Y Kaufmann.
Am J Pathol, 2001 Jul 05; 159(1). PMID: 11438452    Free PMC article.
Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1.
W Tao, D Pennica, +2 authors, A J Levine.
Genes Dev, 2001 Jul 19; 15(14). PMID: 11459829    Free PMC article.
Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.
H G Pálmer, J M González-Sancho, +8 authors, A Muñoz.
J Cell Biol, 2001 Jul 27; 154(2). PMID: 11470825    Free PMC article.
Highly Cited.
The cadherin-catenin superfamily in endocrine tumors.
S Semba, M Yamakawa, H Sasano.
Endocr Pathol, 2001 Aug 02; 12(1). PMID: 11478263
Review.
Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway.
A Danilkovitch-Miagkova, A Miagkov, +3 authors, E J Leonard.
Mol Cell Biol, 2001 Aug 04; 21(17). PMID: 11486025    Free PMC article.
Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1.
E M Sampson, Z K Haque, +5 authors, A S Yee.
EMBO J, 2001 Aug 14; 20(16). PMID: 11500377    Free PMC article.
Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.
F Galbiati, D Volonté, +5 authors, M P Lisanti.
Mol Biol Cell, 2001 Aug 22; 12(8). PMID: 11514613    Free PMC article.
Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis.
X Xia, S Qian, +6 authors, H Zheng.
Proc Natl Acad Sci U S A, 2001 Aug 23; 98(19). PMID: 11517342    Free PMC article.
Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2.
D T Dang, C S Mahatan, +2 authors, V W Yang.
Oncogene, 2001 Aug 25; 20(35). PMID: 11521200    Free PMC article.
Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment.
T Brabletz, A Jung, +5 authors, T Kirchner.
Proc Natl Acad Sci U S A, 2001 Aug 30; 98(18). PMID: 11526241    Free PMC article.
Highly Cited.
Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation.
A Damalas, S Kahan, +2 authors, M Oren.
EMBO J, 2001 Sep 05; 20(17). PMID: 11532955    Free PMC article.
The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation.
N Barker, A Hurlstone, +3 authors, H Clevers.
EMBO J, 2001 Sep 05; 20(17). PMID: 11532957    Free PMC article.
Highly Cited.
Silencing of Wnt signaling and activation of multiple metabolic pathways in response to thyroid hormone-stimulated cell proliferation.
L D Miller, K S Park, +5 authors, S Y Cheng.
Mol Cell Biol, 2001 Sep 05; 21(19). PMID: 11533250    Free PMC article.
The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo.
L Natarajan, N E Witwer, D M Eisenmann.
Genetics, 2001 Sep 19; 159(1). PMID: 11560894    Free PMC article.
E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity.
A Stockinger, A Eger, +2 authors, R Foisner.
J Cell Biol, 2001 Sep 21; 154(6). PMID: 11564756    Free PMC article.
Down-regulation of beta-catenin by activated p53.
E Sadot, B Geiger, M Oren, A Ben-Ze'ev.
Mol Cell Biol, 2001 Sep 21; 21(20). PMID: 11564862    Free PMC article.
Analysis of beta-catenin mutations and alpha-, beta-, and gamma-catenin expression in normal and neoplastic human pituitary tissues.
V Tziortzioti, K H Ruebel, +3 authors, R V Lloyd.
Endocr Pathol, 2001 Oct 03; 12(2). PMID: 11579678
Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p.
S C Abraham, T T Wu, +5 authors, R H Hruban.
Am J Pathol, 2001 Nov 07; 159(5). PMID: 11696422    Free PMC article.
Expression patterns of cellular growth-controlling genes in non-medullary thyroid cancer: basic aspects.
N J Sarlis.
Rev Endocr Metab Disord, 2001 Nov 16; 1(3). PMID: 11708296
Review.
Inhibition of beta-catenin translocation in rodent colorectal tumors: a novel explanation for the protective effect of nonsteroidal antiinflammatory drugs in colorectal cancer.
W A Brown, S A Skinner, D Vogiagis, P E O'Brien.
Dig Dis Sci, 2001 Nov 21; 46(11). PMID: 11713928
Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon.
T Hinoi, M Tani, +7 authors, E R Fearon.
Am J Pathol, 2001 Dec 26; 159(6). PMID: 11733373    Free PMC article.
Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin.
Frank J T Staal, Mascha van Noort, Ger J Strous, Hans C Clevers.
EMBO Rep, 2001 Dec 26; 3(1). PMID: 11751573    Free PMC article.
Highly Cited.
Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro.
A V Tutter, C J Fryer, K A Jones.
Genes Dev, 2001 Dec 26; 15(24). PMID: 11751639    Free PMC article.
Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer.
Yaacov Barak, Debbie Liao, +5 authors, Ronald M Evans.
Proc Natl Acad Sci U S A, 2002 Jan 05; 99(1). PMID: 11756685    Free PMC article.
Highly Cited.
Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia.
Karen A Silverman, Revati Koratkar, Linda D Siracusa, Arthur M Buchberg.
Genome Res, 2002 Jan 10; 12(1). PMID: 11779834    Free PMC article.
An insight into the genetic pathway of adenocarcinoma of the small intestine.
J M D Wheeler, B F Warren, +8 authors, W F Bodmer.
Gut, 2002 Jan 15; 50(2). PMID: 11788563    Free PMC article.
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors.
Barbara Lustig, Boris Jerchow, +8 authors, Jürgen Behrens.
Mol Cell Biol, 2002 Jan 26; 22(4). PMID: 11809809    Free PMC article.
Highly Cited.
Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas.
Y Xin, X L Li, +4 authors, Y C Zhang.
World J Gastroenterol, 2002 Jan 31; 7(1). PMID: 11819733    Free PMC article.
Abnormal beta-catenin gene expression with invasiveness of primary hepatocellular carcinoma in China.
J Cui, X D Zhou, +2 authors, M H Zile.
World J Gastroenterol, 2002 Jan 31; 7(4). PMID: 11819825    Free PMC article.
Beta-catenin--a linchpin in colorectal carcinogenesis?
Newton Alexander Chiang Shuek Wong, Massimo Pignatelli.
Am J Pathol, 2002 Feb 13; 160(2). PMID: 11839557    Free PMC article.
Review.
Food restriction inhibits the growth of intestinal polyps in multiple intestinal neoplasia mouse.
Masakazu Kakuni, Keiichiro Morimura, +4 authors, Shoji Fukushima.
Jpn J Cancer Res, 2002 Apr 03; 93(3). PMID: 11927003    Free PMC article.
Role of beta-catenin/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas.
Yali Zhai, Rong Wu, +6 authors, Kathleen R Cho.
Am J Pathol, 2002 Apr 12; 160(4). PMID: 11943708    Free PMC article.
Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations.
Susan C Abraham, David S Klimstra, +6 authors, Ralph H Hruban.
Am J Pathol, 2002 Apr 12; 160(4). PMID: 11943721    Free PMC article.
Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells.
T Shimada, K Kojima, +2 authors, A Terano.
Gut, 2002 Apr 16; 50(5). PMID: 11950812    Free PMC article.
Chlamydia trachomatis disrupts N-cadherin-dependent cell-cell junctions and sequesters beta-catenin in human cervical epithelial cells.
Walter C Prozialeck, Michael J Fay, +3 authors, Kyle H Ramsey.
Infect Immun, 2002 Apr 16; 70(5). PMID: 11953402    Free PMC article.
Nuclear beta-catenin expression is closely related to ulcerative growth of colorectal carcinoma.
J M Chiang, Y H Wu Chou, +2 authors, J L Lin.
Br J Cancer, 2002 Apr 16; 86(7). PMID: 11953860    Free PMC article.
Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis.
Zongbing You, Daniel Saims, +8 authors, Cun-Yu Wang.
J Cell Biol, 2002 May 01; 157(3). PMID: 11980918    Free PMC article.
beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds.
Sophia S Cheon, Alexander Y L Cheah, +4 authors, Benjamin A Alman.
Proc Natl Acad Sci U S A, 2002 May 02; 99(10). PMID: 11983872    Free PMC article.
Highly Cited.
Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.
Sharon Amit, Ada Hatzubai, +5 authors, Irit Alkalay.
Genes Dev, 2002 May 10; 16(9). PMID: 12000790    Free PMC article.
Highly Cited.
T-cell factors: turn-ons and turn-offs.
Adam Hurlstone, Hans Clevers.
EMBO J, 2002 May 15; 21(10). PMID: 12006483    Free PMC article.
Review.
Genetic and clinical characterisation of familial adenomatous polyposis: a population based study.
A-L Moisio, H Järvinen, P Peltomäki.
Gut, 2002 May 16; 50(6). PMID: 12010888    Free PMC article.
Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation.
Timothy A Chan, Zhenghe Wang, +2 authors, Kenneth W Kinzler.
Proc Natl Acad Sci U S A, 2002 Jun 13; 99(12). PMID: 12060769    Free PMC article.
Nuclear Accumulation of B-Catenin in Human Endocrine Tumors: Association with Ki-67 (MIB-1) Proliferative Activity.
Shuho Semba, Ryoko Kusumi, Takuya Moriya, Hironobu Sasano.
Endocr Pathol, 2002 Jul 13; 11(3). PMID: 12114696
Reduction of intestinal neoplasia with adenomatous polyposis coli gene replacement and COX-2 inhibition is additive.
John I Lew, Yuee Guo, +3 authors, Richard B Arenas.
J Gastrointest Surg, 2002 Jul 20; 6(4). PMID: 12127122
Endostatin is a potential inhibitor of Wnt signaling.
Jun-ichi Hanai, Joachim Gloy, +8 authors, Sergei Sokol.
J Cell Biol, 2002 Jul 31; 158(3). PMID: 12147676    Free PMC article.
Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation.
Slava Chtarbova, Inko Nimmrich, +4 authors, Oliver Müller.
Biochem J, 2002 Aug 03; 367(Pt 3). PMID: 12153396    Free PMC article.
Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis.
Maralice E Conacci-Sorrell, Tamar Ben-Yedidia, +3 authors, Avri Ben-Ze'ev.
Genes Dev, 2002 Aug 17; 16(16). PMID: 12183361    Free PMC article.
APC as a checkpoint gene: the beginning or the end?
Vincent W Yang.
Gastroenterology, 2002 Aug 29; 123(3). PMID: 12198717    Free PMC article.
Review.
A yeast model system for functional analysis of beta-catenin signaling.
Margaret S Lee, Karen A D'Amour, Jackie Papkoff.
J Cell Biol, 2002 Sep 18; 158(6). PMID: 12235124    Free PMC article.
Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferation.
Guangnan Li, Ravi Iyengar.
Proc Natl Acad Sci U S A, 2002 Sep 20; 99(20). PMID: 12239346    Free PMC article.
Frizzled-3 is required for the development of major fiber tracts in the rostral CNS.
Yanshu Wang, Nupur Thekdi, +2 authors, Jeremy Nathans.
J Neurosci, 2002 Sep 28; 22(19). PMID: 12351730    Free PMC article.
Association of hTcf-4 gene expression and mutation with clinicopathological characteristics of hepatocellular carcinoma.
Ying Jiang, Xin-Da Zhou, +2 authors, Xiao-Wu Huang.
World J Gastroenterol, 2002 Oct 16; 8(5). PMID: 12378619    Free PMC article.
Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma.
Rex C Haydon, Andrea Deyrup, +11 authors, Tong-Chuan He.
Int J Cancer, 2002 Oct 29; 102(4). PMID: 12402302    Free PMC article.
Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies.
K B Pedersen, J M Nesland, Ø Fodstad, G M Maelandsmo.
Br J Cancer, 2002 Nov 20; 87(11). PMID: 12439718    Free PMC article.
Expression of E-cadherin and beta-catenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival.
Yong-Ning Zhou, Cai-Pu Xu, +4 authors, Jian-Min Yang.
World J Gastroenterol, 2002 Nov 20; 8(6). PMID: 12439911    Free PMC article.
Analysis of the beta-catenin/T cell factor signaling pathway in 36 gastrointestinal and liver cancer cells.
Tsuneo Ikenoue, Hideaki Ijichi, +8 authors, Masao Omata.
Jpn J Cancer Res, 2002 Dec 04; 93(11). PMID: 12460462    Free PMC article.
Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.
O M Sieber, K Heinimann, +10 authors, I P M Tomlinson.
Proc Natl Acad Sci U S A, 2002 Dec 18; 99(26). PMID: 12486240    Free PMC article.
APC mutation and tumour budding in colorectal cancer.
J R Jass, M Barker, +5 authors, B A Leggett.
J Clin Pathol, 2002 Dec 25; 56(1). PMID: 12499439    Free PMC article.
[Morphogenetic aspects of colorectal cancer].
T Brabletz, T Kirchner.
Pathologe, 2003 Feb 26; 24(1). PMID: 12601477
Review.
Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription.
Rina Rosin-Arbesfeld, Adam Cliffe, Thomas Brabletz, Mariann Bienz.
EMBO J, 2003 Feb 28; 22(5). PMID: 12606575    Free PMC article.
Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway.
Sung Hee Baek, Chrissa Kioussi, +7 authors, Michael G Rosenfeld.
Proc Natl Acad Sci U S A, 2003 Mar 12; 100(6). PMID: 12629224    Free PMC article.
Downregulation of E-cadherin and its undercoat proteins in pituitary growth hormone cell adenomas with prominent fibrous bodies.
Bing Xu, Toshiaki Sano, Katsuhiko Yoshimoto, Shozo Yamada.
Endocr Pathol, 2003 Apr 01; 13(4). PMID: 12665652
Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth.
Syed Haq, Ashour Michael, +6 authors, Thomas Force.
Proc Natl Acad Sci U S A, 2003 Apr 02; 100(8). PMID: 12668767    Free PMC article.
Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun.
Carmen A Blum, Tomoko Tanaka, +5 authors, Roderick H Dashwood.
Mol Carcinog, 2003 Apr 02; 36(4). PMID: 12669311    Free PMC article.
Tyrosine kinase inhibitor STI-571/Gleevec down-regulates the beta-catenin signaling activity.
Lan Zhou, Naili An, +10 authors, Tong-Chuan He.
Cancer Lett, 2003 Apr 23; 193(2). PMID: 12706873    Free PMC article.
Wnt signaling and pulmonary fibrosis.
Edward E Morrisey.
Am J Pathol, 2003 Apr 23; 162(5). PMID: 12707021    Free PMC article.
Review.
The Wnt signaling pathway and its role in tumor development.
B Lustig, J Behrens.
J Cancer Res Clin Oncol, 2003 Apr 23; 129(4). PMID: 12707770
Highly Cited. Review.
HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells.
Tomas Valenta, Jan Lukas, Vladimir Korinek.
Nucleic Acids Res, 2003 Apr 25; 31(9). PMID: 12711682    Free PMC article.
A functional screen in human cells identifies UBF2 as an RNA polymerase II transcription factor that enhances the beta-catenin signaling pathway.
Dorre A Grueneberg, Lourdes Pablo, +3 authors, Jacqueline Papkoff.
Mol Cell Biol, 2003 May 16; 23(11). PMID: 12748295    Free PMC article.
Replicating parvoviruses that target colon cancer cells.
M Malerba, L Daeffler, J Rommelaere, R D Iggo.
J Virol, 2003 May 28; 77(12). PMID: 12767988    Free PMC article.
Reduced expression of Axin correlates with tumour progression of oesophageal squamous cell carcinoma.
M Nakajima, M Fukuchi, +3 authors, H Kuwano.
Br J Cancer, 2003 May 29; 88(11). PMID: 12771989    Free PMC article.
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.
Marc van de Wetering, Irma Oving, +7 authors, Hans Clevers.
EMBO Rep, 2003 May 31; 4(6). PMID: 12776180    Free PMC article.
Highly Cited.
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus manipulates the activity of glycogen synthase kinase-3beta.
Masahiro Fujimuro, S Diane Hayward.
J Virol, 2003 Jun 28; 77(14). PMID: 12829841    Free PMC article.
No major tumorigenic role for beta-catenin in serrated as opposed to conventional colorectal adenomas.
T Yamamoto, K Konishi, +5 authors, K Mitamura.
Br J Cancer, 2003 Jul 03; 89(1). PMID: 12838317    Free PMC article.
Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin.
Matthew H Herynk, Rachael Tsan, Robert Radinsky, Gary E Gallick.
Clin Exp Metastasis, 2003 Jul 15; 20(4). PMID: 12856716
Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis.
David Olmeda, Susanna Castel, Senén Vilaró, Amparo Cano.
Mol Biol Cell, 2003 Jul 15; 14(7). PMID: 12857869    Free PMC article.
Expression of secreted frizzled-related protein 2 in a primary canine mammary tumor cell line: a candidate tumor marker for mammary tumor cells.
Jia-Lin Lee, Ching-Jin Chang, Ling-Ling Chueh, Chung-Tien Lin.
In Vitro Cell Dev Biol Anim, 2003 Jul 18; 39(5-6). PMID: 12866949
A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteins.
Oriano Marin, Victor H Bustos, +6 authors, Jorge E Allende.
Proc Natl Acad Sci U S A, 2003 Aug 20; 100(18). PMID: 12925738    Free PMC article.
Redistribution of β-catenin in response to EGF and lithium signalling in human oesophageal squamous carcinoma cell lines.
Lindsay Jg Jones, Rob B Veale.
Cancer Cell Int, 2003 Sep 06; 3. PMID: 12956888    Free PMC article.
A protein knockdown strategy to study the function of beta-catenin in tumorigenesis.
Feng Cong, Jianxuan Zhang, +2 authors, Harold Varmus.
BMC Mol Biol, 2003 Oct 01; 4. PMID: 14516475    Free PMC article.
Wnt-signalling pathway in ovarian epithelial tumours: increased expression of beta-catenin and GSK3beta.
K Rask, A Nilsson, +5 authors, K Sundfeldt.
Br J Cancer, 2003 Oct 02; 89(7). PMID: 14520463    Free PMC article.
Eradication of pathogenic beta-catenin by Skp1/Cullin/F box ubiquitination machinery.
Yunyun Su, Shinji Ishikawa, Masayuki Kojima, Bo Liu.
Proc Natl Acad Sci U S A, 2003 Oct 18; 100(22). PMID: 14563921    Free PMC article.
Nitric oxide-donating aspirin inhibits beta-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear beta-catenin-TCF association.
Niharika Nath, Khosrow Kashfi, Jie Chen, Basil Rigas.
Proc Natl Acad Sci U S A, 2003 Oct 21; 100(22). PMID: 14566053    Free PMC article.
Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis.
Keiichi Iwaya, Hitoshi Ogawa, +3 authors, Kiyoshi Mukai.
Clin Exp Metastasis, 2003 Nov 06; 20(6). PMID: 14598886
Tumor suppressor gene E-cadherin and its role in normal and malignant cells.
Nives Pećina-Slaus.
Cancer Cell Int, 2003 Nov 14; 3(1). PMID: 14613514    Free PMC article.
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.
Maralice Conacci-Sorrell, Inbal Simcha, +3 authors, Avri Ben-Ze'ev.
J Cell Biol, 2003 Nov 19; 163(4). PMID: 14623871    Free PMC article.
Highly Cited.
Reconstructed beta-catenin/TCF4 signaling in yeast applicable to functional evaluation of APC mutations.
Hidehisa Yamada, Keiji Furuuchi, +7 authors, Hiroyuki Katoh.
Am J Pathol, 2003 Nov 25; 163(6). PMID: 14633595    Free PMC article.
Alterations of beta-catenin pathway in non-melanoma skin tumors: loss of alpha-ABC nuclear reactivity correlates with the presence of beta-catenin gene mutation.
Claudio Doglioni, Sara Piccinin, +7 authors, Roberta Maestro.
Am J Pathol, 2003 Nov 25; 163(6). PMID: 14633602    Free PMC article.
Aberrant crypt foci as microscopic precursors of colorectal cancer.
Lei Cheng, Mao-De Lai.
World J Gastroenterol, 2003 Dec 12; 9(12). PMID: 14669304    Free PMC article.
Review.
Role of APC and DNA mismatch repair genes in the development of colorectal cancers.
Satya Narayan, Deodutta Roy.
Mol Cancer, 2003 Dec 16; 2. PMID: 14672538    Free PMC article.
Review.
TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development.
Ali Nawshad, Elizabeth D Hay.
J Cell Biol, 2003 Dec 24; 163(6). PMID: 14691138    Free PMC article.
Increased expression of a Myc target gene Mina53 in human colon cancer.
Kwesi Teye, Makoto Tsuneoka, +5 authors, Hiroshi Kimura.
Am J Pathol, 2003 Dec 26; 164(1). PMID: 14695334    Free PMC article.
N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA.
Aruna S Jaiswal, Asha S Multani, Sen Pathak, Satya Narayan.
Mol Cancer, 2004 Jan 20; 3. PMID: 14728717    Free PMC article.
Frequent loss of the AXIN1 locus but absence of AXIN1 gene mutations in adenocarcinomas of the gastro-oesophageal junction with nuclear beta-catenin expression.
L B Koppert, A W van der Velden, +5 authors, W N M Dinjens.
Br J Cancer, 2004 Feb 19; 90(4). PMID: 14970870    Free PMC article.
E-cadherin expression is homogeneously reduced in adenoma from patients with familial adenomatous polyposis: an immunohistochemical study of E-cadherin, beta-catenin and cyclooxygenase-2 expression.
M Jungck, F Grünhage, +5 authors, T Sauerbruch.
Int J Colorectal Dis, 2004 Feb 27; 19(5). PMID: 14986031
Distinct activities of the alpha-catenin family, alpha-catulin and alpha-catenin, on beta-catenin-mediated signaling.
Keith D Merdek, Nhan T Nguyen, Deniz Toksoz.
Mol Cell Biol, 2004 Mar 03; 24(6). PMID: 14993280    Free PMC article.
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32.
Mohamed Al-Fageeh, Qingjie Li, +2 authors, Roderick H Dashwood.
Oncogene, 2004 Apr 06; 23(28). PMID: 15064718    Free PMC article.
Gene expression profiling of breast cancers with emphasis of beta-catenin regulation.
Mee Sook Roh, Sook Hee Hong, +5 authors, Tae Ho Hwang.
J Korean Med Sci, 2004 Apr 15; 19(2). PMID: 15082903    Free PMC article.
Early gastric cancer development in a familial adenomatous polyposis patient.
Shouji Shimoyama, Fumio Aoki, +4 authors, Michio Kaminishi.
Dig Dis Sci, 2004 Apr 24; 49(2). PMID: 15104367
Review.
Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells.
Makoto Saegusa, Miki Hashimura, +2 authors, Isao Okayasu.
Am J Pathol, 2004 Apr 28; 164(5). PMID: 15111320    Free PMC article.
Identification of Wnt responsive genes using a murine mammary epithelial cell line model system.
Lisa Taneyhill, Diane Pennica.
BMC Dev Biol, 2004 May 14; 4. PMID: 15140269    Free PMC article.
Pharmacological and genetic modulation of Wnt-targeted Cre-Lox-mediated gene expression in colorectal cancer cells.
Michael Bordonaro, Darina L Lazarova, Alan C Sartorelli.
Nucleic Acids Res, 2004 May 14; 32(8). PMID: 15141037    Free PMC article.
Characterization of the E-cadherin/catenin complex in colorectal carcinoma cell lines.
Mona El-Bahrawy, Richard Poulsom, +4 authors, Ian T Tomlinson.
Int J Exp Pathol, 2004 May 25; 85(2). PMID: 15154912    Free PMC article.
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.
Owen J Sansom, Karen R Reed, +9 authors, Douglas J Winton.
Genes Dev, 2004 Jun 17; 18(12). PMID: 15198980    Free PMC article.
Highly Cited.
Beta-catenin associates with human parainfluenza virus type 3 ribonucleoprotein complex and activates transcription of viral genome RNA in vitro.
Santanu Bose, Amiya K Banerjee.
Gene Expr, 2004 Jun 18; 11(5-6). PMID: 15200236    Free PMC article.
Antisense Tcf inhibits the neoplastic growth of liver cancer cells.
Ying Jiang, Xin-Da Zhou, +6 authors, Xin Wu.
J Cancer Res Clin Oncol, 2004 Jun 29; 130(11). PMID: 15221470
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes.
Philippe Blache, Marc van de Wetering, +5 authors, Philippe Jay.
J Cell Biol, 2004 Jul 09; 166(1). PMID: 15240568    Free PMC article.
Highly Cited.
Medulloblastoma: molecular genetics and animal models.
Corey Raffel.
Neoplasia, 2004 Jul 17; 6(4). PMID: 15256053    Free PMC article.
Review.
Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice.
James Hulit, Chenguang Wang, +9 authors, Richard G Pestell.
Mol Cell Biol, 2004 Aug 18; 24(17). PMID: 15314168    Free PMC article.
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells.
Qingjie Li, Roderick H Dashwood.
J Biol Chem, 2004 Aug 28; 279(44). PMID: 15331612    Free PMC article.
Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling.
Mikihiko Naito, Ryohei Katayama, +11 authors, Takashi Tsuruo.
Mol Cell Biol, 2004 Sep 16; 24(19). PMID: 15367663    Free PMC article.
A novel mouse model for colitis-associated colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sulfate sodium.
Jian-Guo Wang, Dong-Fei Wang, Bing-Jian Lv, Jian-Min Si.
World J Gastroenterol, 2004 Sep 21; 10(20). PMID: 15378773    Free PMC article.
Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.
Shuying Liu, Shuangxing Yu, +5 authors, Xianjun Fang.
J Biol Chem, 2004 Oct 07; 279(49). PMID: 15466414    Free PMC article.
Apoptosis and colorectal cancer.
A J M Watson.
Gut, 2004 Oct 14; 53(11). PMID: 15479695    Free PMC article.
Review.
Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt.
Qiang Tian, Megan C Feetham, +4 authors, Leroy Hood.
Proc Natl Acad Sci U S A, 2004 Oct 20; 101(43). PMID: 15492215    Free PMC article.
Mutation of beta-catenin does not coexist with K-ras mutation in colorectal tumorigenesis.
Kazuhisa Shitoh, Koji Koinuma, +2 authors, Hideo Nagai.
Dig Dis Sci, 2004 Dec 03; 49(10). PMID: 15573917
Cribriform-morular variant of papillary thyroid carcinoma: clue to early detection of familial adenomatous polyposis-associated colon cancer.
Chisato Tomoda, Akira Miyauchi, +8 authors, Kennichi Kakudo.
World J Surg, 2004 Dec 14; 28(9). PMID: 15593462
Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome.
V Johnson, E Volikos, +10 authors, A R J Silver.
Gut, 2005 Jan 14; 54(2). PMID: 15647192    Free PMC article.
The Wnt/beta-catenin signaling pathway targets PPARgamma activity in colon cancer cells.
Emmelie A Jansson, Alexandra Are, +4 authors, Sven Pettersson.
Proc Natl Acad Sci U S A, 2005 Jan 25; 102(5). PMID: 15665104    Free PMC article.
beta-Catenin expression in thyroid follicular lesions: potential role in nuclear envelope changes in papillary carcinomas.
S Rezk, R K Brynes, +4 authors, A Khan.
Endocr Pathol, 2005 Feb 01; 15(4). PMID: 15681857
Review.
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling.
Karina Reiss, Thorsten Maretzky, +4 authors, Paul Saftig.
EMBO J, 2005 Feb 05; 24(4). PMID: 15692570    Free PMC article.
Highly Cited.
L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers.
Nancy Gavert, Maralice Conacci-Sorrell, +4 authors, Avri Ben-Ze'ev.
J Cell Biol, 2005 Feb 18; 168(4). PMID: 15716380    Free PMC article.
Highly Cited.
The links between axin and carcinogenesis.
S Salahshor, J R Woodgett.
J Clin Pathol, 2005 Mar 01; 58(3). PMID: 15735151    Free PMC article.
Review.
Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice.
Wancai Yang, Anna Velcich, +5 authors, Leonard H Augenlicht.
Am J Pathol, 2005 Mar 29; 166(4). PMID: 15793302    Free PMC article.
Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription.
Andrew Street, Andrew Macdonald, Christopher McCormick, Mark Harris.
J Virol, 2005 Mar 30; 79(8). PMID: 15795286    Free PMC article.
G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathway.
Ming Yang, Wendy W Zhong, +4 authors, Songzhu An.
Proc Natl Acad Sci U S A, 2005 Apr 20; 102(17). PMID: 15837931    Free PMC article.
The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway.
Giancarlo Ghiselli, Amit Agrawal.
Biochem J, 2005 Apr 28; 390(Pt 2). PMID: 15853773    Free PMC article.
HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation.
C Jung, R-S Kim, +6 authors, C Kao.
Br J Cancer, 2005 Jun 02; 92(12). PMID: 15928669    Free PMC article.
APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers.
Reetta Kariola, Wael M Abdel-Rahman, +3 authors, Minna Nyström.
Fam Cancer, 2005 Jun 14; 4(2). PMID: 15951972
Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1.
Chunlan Sun, Takashi Yamato, +3 authors, Akira Horii.
J Neurooncol, 2005 Jun 28; 73(2). PMID: 15981102
Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha.
Denise A Chan, Patrick D Sutphin, Shing-Erh Yen, Amato J Giaccia.
Mol Cell Biol, 2005 Jul 19; 25(15). PMID: 16024780    Free PMC article.
Loss of adenomatous polyposis coli gene function disrupts thymic development.
Fotini Gounari, Rui Chang, +4 authors, Khashayarsha Khazaie.
Nat Immunol, 2005 Jul 19; 6(8). PMID: 16025118    Free PMC article.
Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate.
Wan-Mohaiza Dashwood, Orianna Carter, +2 authors, Roderick H Dashwood.
Mutat Res, 2005 Aug 02; 591(1-2). PMID: 16054165    Free PMC article.
Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma.
Soichi Iwai, Wataru Katagiri, +3 authors, Yoshiaki Yura.
J Cancer Res Clin Oncol, 2005 Sep 16; 131(12). PMID: 16163548
Bcr is a negative regulator of the Wnt signalling pathway.
Angelika Ress, Karin Moelling.
EMBO Rep, 2005 Oct 08; 6(11). PMID: 16211085    Free PMC article.
Improved methods for the generation of human gene knockout and knockin cell lines.
Ozlem Topaloglu, Paula J Hurley, +2 authors, Fred Bunz.
Nucleic Acids Res, 2005 Oct 11; 33(18). PMID: 16214806    Free PMC article.
Identifying components of the NF-kappaB pathway in the beneficial Euprymna scolopes-Vibrio fischeri light organ symbiosis.
Michael S Goodson, Mila Kojadinovic, +4 authors, Margaret J McFall-Ngai.
Appl Environ Microbiol, 2005 Nov 05; 71(11). PMID: 16269728    Free PMC article.
Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase.
Q Wang, Y Zhou, X Wang, B M Evers.
Oncogene, 2005 Nov 10; 25(1). PMID: 16278684    Free PMC article.
Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation.
T Akiyoshi, M Nakamura, +5 authors, M Katano.
Gut, 2005 Nov 22; 55(7). PMID: 16299030    Free PMC article.
CK2 as a positive regulator of Wnt signalling and tumourigenesis.
David C Seldin, Esther Landesman-Bollag, +3 authors, Isabel Dominguez.
Mol Cell Biochem, 2005 Dec 14; 274(1-2). PMID: 16342409
Review.
Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction.
Shao-Yong Chen, Gerburg Wulf, +3 authors, Steven P Balk.
Mol Cell Biol, 2006 Jan 24; 26(3). PMID: 16428447    Free PMC article.
Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia.
Anna-Pavlina G Haramis, Adam Hurlstone, +4 authors, Hans C Clevers.
EMBO Rep, 2006 Jan 28; 7(4). PMID: 16439994    Free PMC article.
The Wnt antagonist sFRP1 is downregulated in premalignant large bowel adenomas.
G M Caldwell, C E Jones, +4 authors, D G Morton.
Br J Cancer, 2006 Mar 09; 94(6). PMID: 16523202    Free PMC article.
Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast.
Jürgen Pollheimer, Thomas Loregger, +6 authors, Martin Knöfler.
Am J Pathol, 2006 Mar 28; 168(4). PMID: 16565489    Free PMC article.
Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines.
T Pukrop, F Klemm, +5 authors, C Binder.
Proc Natl Acad Sci U S A, 2006 Mar 30; 103(14). PMID: 16569699    Free PMC article.
Highly Cited.
Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway.
Liora Bachar-Dahan, Janna Goltzmann, Abraham Yaniv, Arnona Gazit.
Mol Biol Cell, 2006 Mar 31; 17(6). PMID: 16571670    Free PMC article.
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation.
Kevin Pruitt, Rebekah L Zinn, +5 authors, Stephen B Baylin.
PLoS Genet, 2006 Apr 06; 2(3). PMID: 16596166    Free PMC article.
Highly Cited.
Regulation of bone mass by Wnt signaling.
Venkatesh Krishnan, Henry U Bryant, Ormond A Macdougald.
J Clin Invest, 2006 May 04; 116(5). PMID: 16670761    Free PMC article.
Highly Cited. Review.
Mutational analysis of the APC gene in cribriform-morula variant of papillary thyroid carcinoma.
Shinya Uchino, Shiro Noguchi, +6 authors, Akira Miyauchi.
World J Surg, 2006 May 09; 30(5). PMID: 16680592
Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes.
Tian-Fang Li, Di Chen, +6 authors, Regis J O'Keefe.
J Biol Chem, 2006 May 13; 281(30). PMID: 16690606    Free PMC article.
IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice.
Toshikatsu Hanada, Takashi Kobayashi, +9 authors, Akihiko Yoshimura.
J Exp Med, 2006 May 24; 203(6). PMID: 16717119    Free PMC article.
Microsatellite instability did not predict individual survival of unselected patients with colorectal cancer.
C Lamberti, S Lundin, +4 authors, T Sauerbruch.
Int J Colorectal Dis, 2006 May 26; 22(2). PMID: 16724208
Repair and regeneration: opportunities for carcinogenesis from tissue stem cells.
Scott V Perryman, Karl G Sylvester.
J Cell Mol Med, 2006 Jun 27; 10(2). PMID: 16796800    Free PMC article.
Review.
Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer.
Michel V Hadjihannas, Martina Brückner, +3 authors, Jürgen Behrens.
Proc Natl Acad Sci U S A, 2006 Jul 04; 103(28). PMID: 16815967    Free PMC article.
The canonical Wnt signalling pathway and its APC partner in colon cancer development.
Jean Schneikert, Jürgen Behrens.
Gut, 2006 Jul 15; 56(3). PMID: 16840506    Free PMC article.
Review.
Functional interaction between peroxisome proliferator-activated receptor gamma and beta-catenin.
Jiajian Liu, Hong Wang, Ying Zuo, Stephen R Farmer.
Mol Cell Biol, 2006 Jul 19; 26(15). PMID: 16847334    Free PMC article.
C3G regulates the size of the cerebral cortex neural precursor population.
Anne K Voss, Danielle L Krebs, Tim Thomas.
EMBO J, 2006 Jul 22; 25(15). PMID: 16858399    Free PMC article.
The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.
Ewa Markiewicz, Katarzyna Tilgner, +11 authors, Christopher J Hutchison.
EMBO J, 2006 Jul 22; 25(14). PMID: 16858403    Free PMC article.
Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires beta-catenin.
Tehnaz N Parakh, Jennifer A Hernandez, +4 authors, John H Nilson.
Proc Natl Acad Sci U S A, 2006 Aug 10; 103(33). PMID: 16895991    Free PMC article.
Wnt expression is not correlated with beta-catenin dysregulation in Dupuytren's Disease.
David B O'Gorman, Yan Wu, +2 authors, Bing Siang Gan.
J Negat Results Biomed, 2006 Sep 01; 5. PMID: 16942611    Free PMC article.
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.
Vanesa Muncan, Owen J Sansom, +8 authors, Alan R Clarke.
Mol Cell Biol, 2006 Sep 07; 26(22). PMID: 16954380    Free PMC article.
Highly Cited.
High-density oligonucleotide microarrays and functional network analysis reveal extended lung carcinogenesis pathway maps and multiple interacting genes in NNK [4-(methylnitrosamino)-1-(3-pyridyle)-1-butanone] induced CD1 mouse lung tumor.
Hekmat Osman Abdel-Aziz, Ichiro Takasaki, +4 authors, Yasuo Takano.
J Cancer Res Clin Oncol, 2006 Sep 16; 133(2). PMID: 16977459
Role of matrix metalloproteinase-7 in colorectal adenomas.
Hale Kirimlioglu, Vedat Kirimlioglu, +4 authors, Fatih Hilmioglu.
Dig Dis Sci, 2006 Sep 30; 51(11). PMID: 17009118
Multiple molecular targets in cancer chemoprevention by curcumin.
Rajesh L Thangapazham, Anuj Sharma, Radha K Maheshwari.
AAPS J, 2006 Oct 10; 8(3). PMID: 17025261    Free PMC article.
Review.
MUC1 oncoprotein functions in activation of fibroblast growth factor receptor signaling.
Jian Ren, Deepak Raina, +3 authors, Donald Kufe.
Mol Cancer Res, 2006 Nov 23; 4(11). PMID: 17114345    Free PMC article.
IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment.
Daniela Diehl, Doris Oesterle, +3 authors, Harald Lahm.
J Carcinog, 2006 Nov 23; 5. PMID: 17118177    Free PMC article.
Characterization of a 60S complex of the adenomatous polyposis coli tumor suppressor protein.
Sreekala Mahadevaiyer, Chong Xu, Barry M Gumbiner.
Biochim Biophys Acta, 2006 Nov 28; 1773(2). PMID: 17126424    Free PMC article.
Regulation of glycogen synthase kinase-3 in patients with affective disorders.
W Timothy O'Brien, Peter S Klein.
Biol Psychiatry, 2007 Jan 16; 61(2). PMID: 17223440    Free PMC article.
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.
Dina Dikovskaya, David Schiffmann, +7 authors, Inke S Näthke.
J Cell Biol, 2007 Jan 18; 176(2). PMID: 17227893    Free PMC article.
Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis.
Alessandro Fichera, Nathaniel Little, +14 authors, Marc Bissonnette.
Cancer Res, 2007 Jan 20; 67(2). PMID: 17234795    Free PMC article.
Aberrant nuclear localization of beta-catenin without genetic alterations in beta-catenin or Axin genes in esophageal cancer.
Junjo Kudo, Tadashi Nishiwaki, +8 authors, Yoshitaka Fujii.
World J Surg Oncol, 2007 Feb 21; 5. PMID: 17309796    Free PMC article.
The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors.
Michael Bordonaro, Darina L Lazarova, Alan C Sartorelli.
Exp Cell Res, 2007 Mar 16; 313(8). PMID: 17359971    Free PMC article.
Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells.
Gregory S Yochum, Shannon McWeeney, +3 authors, Richard H Goodman.
Proc Natl Acad Sci U S A, 2007 Mar 16; 104(9). PMID: 17360646    Free PMC article.
Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5.
Huanchun Zhang, Agnieszka Bialkowska, +5 authors, C Chris Yun.
J Biol Chem, 2007 Apr 14; 282(21). PMID: 17430902    Free PMC article.
Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia.
Takao Senda, Akiko Iizuka-Kogo, Takanori Onouchi, Atsushi Shimomura.
Med Mol Morphol, 2007 Jun 19; 40(2). PMID: 17572842
Review.
Prophylactic laparoscopic-assisted total gastrectomy for hereditary diffuse gastric cancer.
Wesley P Francis, Daniald M Rodrigues, +3 authors, John D Webber.
JSLS, 2007 Jul 27; 11(1). PMID: 17651578    Free PMC article.
Transcriptional network governing the angiogenic switch in human pancreatic cancer.
Amir Abdollahi, Christian Schwager, +11 authors, Peter E Huber.
Proc Natl Acad Sci U S A, 2007 Jul 27; 104(31). PMID: 17652168    Free PMC article.
Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis.
Amr M Ghaleb, Beth B McConnell, +3 authors, Vincent W Yang.
Cancer Res, 2007 Aug 03; 67(15). PMID: 17671182    Free PMC article.
The TCF7L2 locus and type 1 diabetes.
Hui-Qi Qu, Constantin Polychronakos.
BMC Med Genet, 2007 Aug 09; 8. PMID: 17683561    Free PMC article.
Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitination.
Zhongde Ye, Elaine O Petrof, +2 authors, Jun Sun.
Am J Pathol, 2007 Aug 11; 171(3). PMID: 17690189    Free PMC article.
Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor.
Zahid Khan, Sapna Vijayakumar, +2 authors, Anna Bafico.
Mol Cell Biol, 2007 Aug 19; 27(20). PMID: 17698587    Free PMC article.
Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium.
Pauline Bastide, Charbel Darido, +9 authors, Philippe Jay.
J Cell Biol, 2007 Aug 19; 178(4). PMID: 17698607    Free PMC article.
Highly Cited.
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Natalia Mitin, Laurie Betts, +3 authors, Kent L Rossman.
Nat Struct Mol Biol, 2007 Aug 21; 14(9). PMID: 17704816    Free PMC article.
WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer.
Hirohide Yoshikawa, Kenichi Matsubara, +8 authors, Curtis C Harris.
Mol Biol Cell, 2007 Sep 01; 18(11). PMID: 17761539    Free PMC article.
Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells.
Débora Sinner, Jennifer J Kordich, +6 authors, James M Wells.
Mol Cell Biol, 2007 Sep 19; 27(22). PMID: 17875931    Free PMC article.
Highly Cited.
Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development.
Yansong Bian, Thomas J Knobloch, +5 authors, Boris Pasche.
Hum Mol Genet, 2007 Sep 25; 16(24). PMID: 17890272    Free PMC article.
Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia.
Kosei Ishida, Satoshi Ito, +4 authors, Tsutomu Nohno.
Mol Cancer, 2007 Oct 10; 6. PMID: 17922924    Free PMC article.
Genetic defects underlying Peutz-Jeghers syndrome (PJS) and exclusion of the polarity-associated MARK/Par1 gene family as potential PJS candidates.
W W J de Leng, M Jansen, +10 authors, G J A Offerhaus.
Clin Genet, 2007 Oct 11; 72(6). PMID: 17924967    Free PMC article.
Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia?
Abderrahmane Kaidi, Morganaden Moorghen, Ann Caroline Williams, Christos Paraskeva.
Gut, 2007 Oct 17; 56(11). PMID: 17938437    Free PMC article.
Increased expression of hLRH-1 in human gastric cancer and its implication in tumorigenesis.
Shui-Liang Wang, De-Zhu Zheng, +5 authors, Zhong-Yong Zhu.
Mol Cell Biochem, 2007 Oct 24; 308(1-2). PMID: 17952562
Wnt signaling in ovarian tumorigenesis.
T A Gatcliffe, B J Monk, K Planutis, R F Holcombe.
Int J Gynecol Cancer, 2007 Nov 08; 18(5). PMID: 17986238    Free PMC article.
Systematic Review.
Alpha-catenin is essential in intestinal adenoma formation.
Hiroyuki Shibata, Hiroshi Takano, +9 authors, Tetsuo Noda.
Proc Natl Acad Sci U S A, 2007 Nov 09; 104(46). PMID: 17989230    Free PMC article.
PPAR delta as a therapeutic target in metabolic disease.
Shannon M Reilly, Chih-Hao Lee.
FEBS Lett, 2007 Nov 27; 582(1). PMID: 18036566    Free PMC article.
Review.
Amyloid precursor protein modulates beta-catenin degradation.
Yuzhi Chen, Angela M Bodles.
J Neuroinflammation, 2007 Dec 12; 4. PMID: 18070361    Free PMC article.
The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology.
T Nakamura, T Nakamura, K Matsumoto.
J Cell Mol Med, 2007 Dec 20; 12(2). PMID: 18088386    Free PMC article.
Review.
PPAR-gamma ligand promotes the growth of APC-mutated HT-29 human colon cancer cells in vitro and in vivo.
I K Choi, Y H Kim, J S Kim, J H Seo.
Invest New Drugs, 2007 Dec 28; 26(3). PMID: 18161004
ShRNA-mediated gene silencing of beta-catenin inhibits growth of human colon cancer cells.
Wen-Sheng Huang, Jian-Ping Wang, +3 authors, Jin-Ping Ma.
World J Gastroenterol, 2007 Dec 29; 13(48). PMID: 18161931    Free PMC article.
Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling.
Xing Guo, Alejandro Ramirez, +3 authors, Xiao-Fan Wang.
Genes Dev, 2008 Jan 04; 22(1). PMID: 18172167    Free PMC article.
Highly Cited.
Cancer in inflammatory bowel disease.
Jianlin Xie, Steven H Itzkowitz.
World J Gastroenterol, 2008 Jan 18; 14(3). PMID: 18200660    Free PMC article.
Highly Cited. Review.
Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome.
Jinglan Xu, Momoko Suzuki, +9 authors, Tomoki Naoe.
Br J Haematol, 2008 Jan 26; 140(4). PMID: 18217891    Free PMC article.
Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains.
Hoanh Tran, Fumihiko Hamada, Thomas Schwarz-Romond, Mariann Bienz.
Genes Dev, 2008 Feb 19; 22(4). PMID: 18281465    Free PMC article.
SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development.
Daniel Kelberman, Sandra C P de Castro, +14 authors, Mehul T Dattani.
J Clin Endocrinol Metab, 2008 Feb 21; 93(5). PMID: 18285410    Free PMC article.
OSTM1 regulates beta-catenin/Lef1 interaction and is required for Wnt/beta-catenin signaling.
Michael E Feigin, Craig C Malbon.
Cell Signal, 2008 Feb 26; 20(5). PMID: 18296023    Free PMC article.
Beyond good and evil in the oral cavity: insights into host-microbe relationships derived from transcriptional profiling of gingival cells.
M Handfield, H V Baker, R J Lamont.
J Dent Res, 2008 Feb 26; 87(3). PMID: 18296603    Free PMC article.
Review.
Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung.
Julien D F Licchesi, William H Westra, +3 authors, James G Herman.
Carcinogenesis, 2008 Mar 01; 29(5). PMID: 18308762    Free PMC article.
The Wnt signaling pathway: aging gracefully as a protectionist?
Kenneth Maiese, Faqi Li, Zhao Zhong Chong, Yan Chen Shang.
Pharmacol Ther, 2008 Mar 04; 118(1). PMID: 18313758    Free PMC article.
Review.
P-cadherin and beta-catenin are useful prognostic markers in breast cancer patients; beta-catenin interacts with heat shock protein Hsp27.
Mariel A Fanelli, Magdalena Montt-Guevara, +6 authors, Daniel R Ciocca.
Cell Stress Chaperones, 2008 Mar 06; 13(2). PMID: 18320359    Free PMC article.
The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression.
Elizabeth Vincan, Nick Barker.
Clin Exp Metastasis, 2008 Mar 20; 25(6). PMID: 18350253
Review.
Phosphorylation of beta-catenin by PKA promotes ATP-induced proliferation of vascular smooth muscle cells.
Sebastien Taurin, Nathan Sandbo, +2 authors, Nickolai O Dulin.
Am J Physiol Cell Physiol, 2008 Mar 21; 294(5). PMID: 18353896    Free PMC article.
HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization.
Yu Li, Xiaowu Zhang, +2 authors, Michael J Comb.
J Biol Chem, 2008 Mar 22; 283(19). PMID: 18356165    Free PMC article.
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts.
Shuying Liu, Xianjun Fang, +8 authors, Gordon B Mills.
Proc Natl Acad Sci U S A, 2008 Mar 28; 105(13). PMID: 18367674    Free PMC article.
CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes.
Brandi A Thompson, Véronique Tremblay, Grace Lin, Daniel A Bochar.
Mol Cell Biol, 2008 Apr 02; 28(12). PMID: 18378692    Free PMC article.
alphaE-catenin is not a significant regulator of beta-catenin signaling in the developing mammalian brain.
Wen-Hui Lien, Olga Klezovitch, Manda Null, Valeri Vasioukhin.
J Cell Sci, 2008 Apr 10; 121(Pt 9). PMID: 18397997    Free PMC article.
Inhibition of beta-catenin signaling causes defects in postnatal cartilage development.
Mo Chen, Mei Zhu, +5 authors, Regis J O'Keefe.
J Cell Sci, 2008 Apr 10; 121(Pt 9). PMID: 18397998    Free PMC article.
Helicobacter hepaticus infection promotes colon tumorigenesis in the BALB/c-Rag2(-/-) Apc(Min/+) mouse.
Claude M Nagamine, Jane J Sohn, +3 authors, David B Schauer.
Infect Immun, 2008 Apr 16; 76(6). PMID: 18411292    Free PMC article.
Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer.
Wei Zhang, Sabine C Glöckner, +9 authors, Stephen B Baylin.
Cancer Res, 2008 Apr 17; 68(8). PMID: 18413743    Free PMC article.
Reorganisation of Wnt-response pathways in colorectal tumorigenesis.
G M Caldwell, C E Jones, +3 authors, G M Matthews.
Br J Cancer, 2008 Apr 17; 98(8). PMID: 18414471    Free PMC article.
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
Ron Firestein, Gil Blander, +10 authors, David A Sinclair.
PLoS One, 2008 Apr 17; 3(4). PMID: 18414679    Free PMC article.
Highly Cited.
REIC/Dkk-3 induces cell death in human malignant glioma.
Yoshifumi Mizobuchi, Kazuhito Matsuzaki, +4 authors, Shinji Nagahiro.
Neuro Oncol, 2008 Apr 30; 10(3). PMID: 18443132    Free PMC article.
Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc.
Upal K Basu Roy, Rebecca S Henkhaus, +3 authors, Eugene W Gerner.
Mol Carcinog, 2008 Apr 30; 47(12). PMID: 18444242    Free PMC article.
Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression.
Rudolf Götz.
Cancer Cell Int, 2008 May 22; 8. PMID: 18492263    Free PMC article.
DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications.
Xia Jiang, Jing Tan, +9 authors, Qiang Yu.
Cancer Cell, 2008 Jun 10; 13(6). PMID: 18538736    Free PMC article.
Stabilizing mutation of CTNNB1/beta-catenin and protein accumulation analyzed in a large series of parathyroid tumors of Swedish patients.
Peyman Björklund, Daniel Lindberg, Göran Akerström, Gunnar Westin.
Mol Cancer, 2008 Jun 11; 7. PMID: 18541010    Free PMC article.
MUC1 oncoprotein promotes growth and survival of human multiple myeloma cells.
Takeshi Kawano, Rehan Ahmad, +3 authors, Donald Kufe.
Int J Oncol, 2008 Jun 26; 33(1). PMID: 18575761    Free PMC article.
Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast.
Michael J Hayes, Dafydd Thomas, +2 authors, Celina G Kleer.
Clin Cancer Res, 2008 Jul 03; 14(13). PMID: 18593979    Free PMC article.
Roles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cells.
Paul M Evans, Chunming Liu.
Acta Biochim Biophys Sin (Shanghai), 2008 Jul 08; 40(7). PMID: 18604447    Free PMC article.
Review.
Wnt signaling: the good and the bad.
Xi Chen, Jun Yang, Paul M Evans, Chunming Liu.
Acta Biochim Biophys Sin (Shanghai), 2008 Jul 08; 40(7). PMID: 18604449    Free PMC article.
Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract.
Ammar Natalwala, Robert Spychal, Chris Tselepis.
World J Gastroenterol, 2008 Jul 09; 14(24). PMID: 18609701    Free PMC article.
Review.
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer.
Wei Tang, Michael Dodge, +3 authors, Lawrence Lum.
Proc Natl Acad Sci U S A, 2008 Jul 16; 105(28). PMID: 18621708    Free PMC article.
The intestinal stem cell.
Nick Barker, Marc van de Wetering, Hans Clevers.
Genes Dev, 2008 Jul 17; 22(14). PMID: 18628392    Free PMC article.
Highly Cited. Review.
Deficiency of Mbd2 attenuates Wnt signaling.
Toby J Phesse, Lee Parry, +4 authors, Alan R Clarke.
Mol Cell Biol, 2008 Jul 23; 28(19). PMID: 18644872    Free PMC article.
A novel function of adenomatous polyposis coli (APC) in regulating DNA repair.
Aruna S Jaiswal, Satya Narayan.
Cancer Lett, 2008 Jul 30; 271(2). PMID: 18662849    Free PMC article.
Review.
Signaling function of alpha-catenin in microtubule regulation.
Michael Shtutman, Alexander Chausovsky, +7 authors, Alexander D Bershadsky.
Cell Cycle, 2008 Aug 05; 7(15). PMID: 18677116    Free PMC article.
The WNT signalling pathway and diabetes mellitus.
T Jin.
Diabetologia, 2008 Aug 13; 51(10). PMID: 18696049
Review.
A novel functional screen in human cells identifies MOCA as a negative regulator of Wnt signaling.
Elanite Caspi, Rina Rosin-Arbesfeld.
Mol Biol Cell, 2008 Aug 22; 19(11). PMID: 18716063    Free PMC article.
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.
Nozomi Togo, Susumu Ohwada, +11 authors, Tetsu Akiyama.
World J Gastroenterol, 2008 Aug 30; 14(31). PMID: 18756595    Free PMC article.
Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice.
Teruaki Fujishita, Koji Aoki, +2 authors, Makoto M Taketo.
Proc Natl Acad Sci U S A, 2008 Sep 05; 105(36). PMID: 18768809    Free PMC article.
Switch of transforming growth factor beta function from tumor suppression to stimulation in adenomatous polyposis coli (APC) knocked-down human colon carcinoma cells.
Hongmei Wang, Moltira Promkan, Guangming Liu, Subhas Chakrabarty.
Cancer Lett, 2008 Sep 09; 272(2). PMID: 18774639    Free PMC article.
E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8.
Erick J Morris, Jun-Yuan Ji, +7 authors, Nicholas J Dyson.
Nature, 2008 Sep 17; 455(7212). PMID: 18794899    Free PMC article.
Highly Cited.
beta-catenin mediates glandular formation and dysregulation of beta-catenin induces hyperplasia formation in the murine uterus.
J-W Jeong, H S Lee, +5 authors, F J DeMayo.
Oncogene, 2008 Sep 23; 28(1). PMID: 18806829    Free PMC article.
Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells.
Lizheng Guo, Diansheng Zhong, +9 authors, Wei Zhou.
Mol Cancer Res, 2008 Sep 30; 6(9). PMID: 18819930    Free PMC article.
Therapeutic potential of replication-selective oncolytic adenoviruses on cells from familial and sporadic desmoid tumors.
Inge Peerlinck, Saeid Amini-Nik, +4 authors, Georges Vassaux.
Clin Cancer Res, 2008 Oct 03; 14(19). PMID: 18829497    Free PMC article.
Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo.
Anita Milicic, Lea-Anne Harrison, +17 authors, Janusz A Z Jankowski.
Cancer Res, 2008 Oct 03; 68(19). PMID: 18829530    Free PMC article.
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Zhenghong Lin, Chan Gao, +3 authors, Ye-Guang Chen.
J Biol Chem, 2008 Oct 08; 283(48). PMID: 18838381    Free PMC article.
Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients.
E Bakhtadze, C Cervin, +11 authors, L C Groop.
Diabetologia, 2008 Oct 08; 51(12). PMID: 18839133
c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway.
Dong Hu, Wenfeng Fang, +4 authors, Wancai Yang.
Carcinogenesis, 2008 Oct 28; 29(12). PMID: 18952597    Free PMC article.
The beta-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression.
Vânia Gonçalves, Paulo Matos, Peter Jordan.
RNA, 2008 Oct 28; 14(12). PMID: 18952824    Free PMC article.
Voluntary exercise inhibits intestinal tumorigenesis in Apc(Min/+) mice and azoxymethane/dextran sulfate sodium-treated mice.
Jihyeung Ju, Bonnie Nolan, +4 authors, Chung S Yang.
BMC Cancer, 2008 Nov 04; 8. PMID: 18976499    Free PMC article.
PCAF acetylates {beta}-catenin and improves its stability.
Xinjian Ge, Qihuang Jin, +2 authors, Qiwei Zhai.
Mol Biol Cell, 2008 Nov 07; 20(1). PMID: 18987336    Free PMC article.
Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling.
Marc S Raab, Iris Breitkreutz, +10 authors, Klaus Podar.
Blood, 2008 Nov 20; 113(7). PMID: 19018094    Free PMC article.
B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver.
Karen R Reed, Dimitris Athineos, +6 authors, Owen J Sansom.
Proc Natl Acad Sci U S A, 2008 Nov 27; 105(48). PMID: 19033191    Free PMC article.
Expression of Wnt4 in human pituitary adenomas regulates activation of the beta-catenin-independent pathway.
Takashi Miyakoshi, Mao Takei, +4 authors, Robert Yoshiyuki Osamura.
Endocr Pathol, 2008 Nov 27; 19(4). PMID: 19034702
A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways.
Yewseok Suh, Farrukh Afaq, Jeremy J Johnson, Hasan Mukhtar.
Carcinogenesis, 2008 Nov 28; 30(2). PMID: 19037088    Free PMC article.
The aurora kinase A regulates GSK-3beta in gastric cancer cells.
A A Dar, A Belkhiri, W El-Rifai.
Oncogene, 2008 Dec 09; 28(6). PMID: 19060929    Free PMC article.
WIF-1 promoter region hypermethylation as an adjuvant diagnostic marker for non-small cell lung cancer-related malignant pleural effusions.
Tsung-Ming Yang, Shaw-Wei Leu, +6 authors, Cheng-Ta Yang.
J Cancer Res Clin Oncol, 2008 Dec 17; 135(7). PMID: 19085002
Crypt stem cells as the cells-of-origin of intestinal cancer.
Nick Barker, Rachel A Ridgway, +7 authors, Hans Clevers.
Nature, 2008 Dec 19; 457(7229). PMID: 19092804
Highly Cited.
Diet and epigenetics in colon cancer.
Minna Nystrom, Marja Mutanen.
World J Gastroenterol, 2009 Jan 14; 15(3). PMID: 19140224    Free PMC article.
The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex.
Yukako Yokota, Woo-Yang Kim, +5 authors, E S Anton.
Neuron, 2009 Jan 17; 61(1). PMID: 19146812    Free PMC article.
Novel Wnt antagonists target porcupine and Axin.
Jing-Ruey J Yeh, Randall T Peterson.
Nat Chem Biol, 2009 Jan 17; 5(2). PMID: 19148172
Qualitative analysis of Adenomatous Polyposis Coli promoter: hypermethylation, engagement and effects on survival of patients with esophageal cancer in a high risk region of the world, a potential molecular marker.
Maryam Zare, Ferdous Rastgar Jazii, +3 authors, Mansour Yazdanbod.
BMC Cancer, 2009 Jan 20; 9. PMID: 19149902    Free PMC article.
BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling.
Ni Tang, Wen-Xin Song, +20 authors, Tong-Chuan He.
J Cell Mol Med, 2009 Jan 30; 13(8B). PMID: 19175684    Free PMC article.
Wnt signaling, lgr5, and stem cells in the intestine and skin.
Andrea Haegebarth, Hans Clevers.
Am J Pathol, 2009 Feb 07; 174(3). PMID: 19197002    Free PMC article.
Highly Cited. Review.
Discovery of inhibitors of aberrant gene transcription from Libraries of DNA binding molecules: inhibition of LEF-1-mediated gene transcription and oncogenic transformation.
James S Stover, Jin Shi, +2 authors, Dale L Boger.
J Am Chem Soc, 2009 Feb 17; 131(9). PMID: 19216569    Free PMC article.
Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression.
Diego A Rodriguez, Julio C Tapia, +5 authors, Andrew F G Quest.
Mol Biol Cell, 2009 Feb 27; 20(8). PMID: 19244345    Free PMC article.
An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET).
H A Rogers, S Miller, +3 authors, R G Grundy.
Br J Cancer, 2009 Mar 19; 100(8). PMID: 19293793    Free PMC article.
The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity.
Erin A Kimbrel, Andrew L Kung.
J Biol Chem, 2009 Mar 20; 284(19). PMID: 19297328    Free PMC article.
Nuclear accumulation of beta-catenin protein indicates activation of wnt signaling in chemically induced rat nephroblastomas.
David Ehrlich, Elisabeth Bruder, +5 authors, Robert Koesters.
Pediatr Dev Pathol, 2009 Apr 08; 13(1). PMID: 19348510    Free PMC article.
Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors.
Razvan L Miclea, Marcel Karperien, +10 authors, Els C Robanus-Maandag.
BMC Dev Biol, 2009 Apr 10; 9. PMID: 19356224    Free PMC article.
Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma.
G Akiri, M M Cherian, +3 authors, S A Aaronson.
Oncogene, 2009 Apr 21; 28(21). PMID: 19377513    Free PMC article.
Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug.
Makoto Saegusa, Miki Hashimura, Takeshi Kuwata, Isao Okayasu.
Am J Pathol, 2009 Apr 25; 174(6). PMID: 19389926    Free PMC article.
URG11 promotes gastric cancer growth and invasion by activation of beta-catenin signalling pathway.
Rui Du, Lin Xia, +9 authors, Daiming Fan.
J Cell Mol Med, 2009 May 06; 14(3). PMID: 19413886    Free PMC article.
Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine.
Beth B McConnell, Agnieszka B Bialkowska, +3 authors, Vincent W Yang.
Cancer Res, 2009 May 14; 69(10). PMID: 19435907    Free PMC article.
Murine models of colorectal cancer.
Joshua M Uronis, David W Threadgill.
Mamm Genome, 2009 May 16; 20(5). PMID: 19444507    Free PMC article.
Review.
A two-step model for colon adenoma initiation and progression caused by APC loss.
Reid A Phelps, Stephanie Chidester, +7 authors, David A Jones.
Cell, 2009 May 20; 137(4). PMID: 19450512    Free PMC article.
Highly Cited.
Mitogen-activated protein kinases and Wnt/beta-catenin signaling: Molecular conversations among signaling pathways.
Rama Kamesh Bikkavilli, Craig C Malbon.
Commun Integr Biol, 2009 Jun 11; 2(1). PMID: 19513264    Free PMC article.
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.
Mark M Pomerantz, Nasim Ahmadiyeh, +23 authors, Matthew L Freedman.
Nat Genet, 2009 Jun 30; 41(8). PMID: 19561607    Free PMC article.
Highly Cited.
Sample type bias in the analysis of cancer genomes.
David A Solomon, Jung-Sik Kim, +6 authors, Todd Waldman.
Cancer Res, 2009 Jul 02; 69(14). PMID: 19567670    Free PMC article.
Wnt signalling and cancer stem cells.
Jesús Espada, Moisés B Calvo, Silvia Díaz-Prado, Vanessa Medina.
Clin Transl Oncol, 2009 Jul 04; 11(7). PMID: 19574199
Review.
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.
Don X Nguyen, Anne C Chiang, +5 authors, Joan Massagué.
Cell, 2009 Jul 07; 138(1). PMID: 19576624    Free PMC article.
Highly Cited.
Wnt/beta-catenin signaling: components, mechanisms, and diseases.
Bryan T MacDonald, Keiko Tamai, Xi He.
Dev Cell, 2009 Jul 22; 17(1). PMID: 19619488    Free PMC article.
Highly Cited. Review.
Diet synergistically affects helicobacter pylori-induced gastric carcinogenesis in nonhuman primates.
Hui Liu, D Scott Merrell, +4 authors, Andre Dubois.
Gastroenterology, 2009 Jul 23; 137(4). PMID: 19622359    Free PMC article.
Regulation of Wnt/beta-catenin signaling by protein kinases.
Esther M Verheyen, Cara J Gottardi.
Dev Dyn, 2009 Jul 23; 239(1). PMID: 19623618    Free PMC article.
Review.
Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis.
Changgong Li, Aimin Li, +7 authors, Parviz Minoo.
Dev Biol, 2009 Jul 28; 334(1). PMID: 19631635    Free PMC article.
Acute overexpression of Myc in intestinal epithelium recapitulates some but not all the changes elicited by Wnt/beta-catenin pathway activation.
Andrew J Finch, Laura Soucek, +2 authors, Gerard I Evan.
Mol Cell Biol, 2009 Jul 29; 29(19). PMID: 19635809    Free PMC article.
Nuclear-cytoplasmic shuttling of menin regulates nuclear translocation of {beta}-catenin.
Yanan Cao, Ruixin Liu, +5 authors, Guang Ning.
Mol Cell Biol, 2009 Aug 05; 29(20). PMID: 19651895    Free PMC article.
Expression of adenomatous polyposis coli protein in reactive astrocytes in hippocampus of kainic acid-induced rat.
Ha Na Lee, Gye Sun Jeon, +2 authors, Sa Sun Cho.
Neurochem Res, 2009 Aug 06; 35(1). PMID: 19655246
Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton.
Maria Almeida, Elena Ambrogini, +2 authors, Robert L Jilka.
J Biol Chem, 2009 Aug 07; 284(40). PMID: 19657144    Free PMC article.
Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells.
Pay-Chin Leow, Quan Tian, +2 authors, Pui-Lai Rachel Ee.
Invest New Drugs, 2009 Sep 05; 28(6). PMID: 19730790
A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.
Hui Fu, Jun Cai, +9 authors, Charles D Stiles.
J Neurosci, 2009 Sep 11; 29(36). PMID: 19741146    Free PMC article.
Modulation of the tumor suppressor protein alpha-catenin by ischemic microenvironment.
Claire L Plumb, Una Adamcic, +3 authors, Brenda L Coomber.
Am J Pathol, 2009 Sep 12; 175(4). PMID: 19745064    Free PMC article.
Beta-catenin nuclear labeling is a common feature of sessile serrated adenomas and correlates with early neoplastic progression after BRAF activation.
Shinichi Yachida, Shiyama Mudali, +2 authors, Christine A Iacobuzio-Donahue.
Am J Surg Pathol, 2009 Sep 12; 33(12). PMID: 19745699    Free PMC article.
Changes in CpG islands promoter methylation patterns during ductal breast carcinoma progression.
Mohammad Obaidul Hoque, Maria Prencipe, +19 authors, Paola Parrella.
Cancer Epidemiol Biomarkers Prev, 2009 Oct 01; 18(10). PMID: 19789364    Free PMC article.
A gene expression classifier of node-positive colorectal cancer.
Paul F Meeh, Christopher L Farrell, +9 authors, Phillip J Buckhaults.
Neoplasia, 2009 Oct 02; 11(10). PMID: 19794966    Free PMC article.
Modular Cre/lox system and genetic therapeutics for colorectal cancer.
Michael Bordonaro.
J Biomed Biotechnol, 2009 Oct 08; 2009. PMID: 19809520    Free PMC article.
Review.
The kinase TNIK is an essential activator of Wnt target genes.
Tokameh Mahmoudi, Vivian S W Li, +5 authors, Hans Clevers.
EMBO J, 2009 Oct 10; 28(21). PMID: 19816403    Free PMC article.
Wnt pathway in pulmonary fibrosis in the bleomycin mouse model.
Li Liu, Benjamin Carron, +3 authors, William Rom.
J Environ Pathol Toxicol Oncol, 2009 Oct 13; 28(2). PMID: 19817697    Free PMC article.
Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells.
Haluk Yuzugullu, Khemais Benhaj, +9 authors, Mehmet Ozturk.
Mol Cancer, 2009 Oct 24; 8. PMID: 19849855    Free PMC article.
Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis.
Jeffrey B Brown, Goo Lee, +9 authors, Terrence A Barrett.
Gastroenterology, 2009 Nov 03; 138(2). PMID: 19879273    Free PMC article.
KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin.
Paul M Evans, Xi Chen, Wen Zhang, Chunming Liu.
Mol Cell Biol, 2009 Nov 11; 30(2). PMID: 19901072    Free PMC article.
Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling.
Jianhui Guo, Tolga Cagatay, +11 authors, Wanguo Liu.
PLoS One, 2009 Dec 04; 4(11). PMID: 19956716    Free PMC article.
Controlling destiny through chemistry: small-molecule regulators of cell fate.
Ari J Firestone, James K Chen.
ACS Chem Biol, 2009 Dec 17; 5(1). PMID: 20000447    Free PMC article.
Review.
Complete deletion of Apc results in severe polyposis in mice.
A F Cheung, A M Carter, +5 authors, T Jacks.
Oncogene, 2009 Dec 17; 29(12). PMID: 20010873    Free PMC article.
Bi-directional SIFT predicts a subset of activating mutations.
William Lee, Yan Zhang, +2 authors, Zemin Zhang.
PLoS One, 2009 Dec 17; 4(12). PMID: 20011534    Free PMC article.
Luteolin inhibits cell proliferation during Azoxymethane-induced experimental colon carcinogenesis via Wnt/ β-catenin pathway.
Pandurangan Ashokkumar, Ganapasam Sudhandiran.
Invest New Drugs, 2009 Dec 17; 29(2). PMID: 20013030
Molecular origins of cancer: Molecular basis of colorectal cancer.
Sanford D Markowitz, Monica M Bertagnolli.
N Engl J Med, 2009 Dec 19; 361(25). PMID: 20018966    Free PMC article.
Highly Cited. Review.
Dickkopf-1 promotes hyperglycemia-induced accumulation of mesangial matrix and renal dysfunction.
Chun-Liang Lin, Jeng-Yi Wang, +3 authors, Feng-Sheng Wang.
J Am Soc Nephrol, 2009 Dec 19; 21(1). PMID: 20019166    Free PMC article.
The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression: crosstalk with the Wnt, Notch, and PI3K pathways.
Carlos S Moreno.
Am J Pathol, 2009 Dec 19; 176(2). PMID: 20019190    Free PMC article.
Differences in protein expression and gene amplification of cyclins between colon and rectal adenocarcinomas.
Rolf Aamodt, Kristin Jonsdottir, +3 authors, Ida R K Bukholm.
Gastroenterol Res Pract, 2009 Dec 24; 2009. PMID: 20029639    Free PMC article.
The loss of tuberin promotes cell invasion through the ß-catenin pathway.
Elizabeth A Barnes, Heidi L Kenerson, Baldwin C Mak, Raymond S Yeung.
Am J Respir Cell Mol Biol, 2010 Jan 01; 43(5). PMID: 20042714    Free PMC article.
Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate beta-catenin activity in colon cancer cells.
Jan B Egan, Patricia A Thompson, +5 authors, Peter W Jurutka.
Mol Carcinog, 2010 Jan 01; 49(4). PMID: 20043299    Free PMC article.
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).
Bin Zhao, Li Li, +2 authors, Kun-Liang Guan.
Genes Dev, 2010 Jan 06; 24(1). PMID: 20048001    Free PMC article.
Highly Cited.
Searching for adult stem cells in the intestine.
Hans Clevers.
EMBO Mol Med, 2010 Jan 06; 1(5). PMID: 20049728    Free PMC article.
Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion.
Frédéric Varnat, Arnaud Duquet, +4 authors, Ariel Ruiz i Altaba.
EMBO Mol Med, 2010 Jan 06; 1(6-7). PMID: 20049737    Free PMC article.
Highly Cited.
CanProVar: a human cancer proteome variation database.
Jing Li, Dexter T Duncan, Bing Zhang.
Hum Mutat, 2010 Jan 07; 31(3). PMID: 20052754    Free PMC article.
Statistical method on nonrandom clustering with application to somatic mutations in cancer.
Jingjing Ye, Adam Pavlicek, +2 authors, Chi-Hse Teng.
BMC Bioinformatics, 2010 Jan 08; 11. PMID: 20053295    Free PMC article.
Dietary intake of pterostilbene, a constituent of blueberries, inhibits the beta-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats.
Shiby Paul, Andrew J DeCastro, +7 authors, Nanjoo Suh.
Carcinogenesis, 2010 Jan 12; 31(7). PMID: 20061362    Free PMC article.
Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells.
Jason B Wright, Seth J Brown, Michael D Cole.
Mol Cell Biol, 2010 Jan 13; 30(6). PMID: 20065031    Free PMC article.
Highly Cited.
NF-kappaB as a critical link between inflammation and cancer.
Michael Karin.
Cold Spring Harb Perspect Biol, 2010 Jan 13; 1(5). PMID: 20066113    Free PMC article.
Highly Cited. Review.
Matrix metalloproteinase-9 functions as a tumor suppressor in colitis-associated cancer.
Pallavi Garg, Dittakavi Sarma, +4 authors, Shanthi V Sitaraman.
Cancer Res, 2010 Jan 14; 70(2). PMID: 20068187    Free PMC article.
Dietary feeding of grape seed extract prevents intestinal tumorigenesis in APCmin/+ mice.
Balaiya Velmurugan, Rana P Singh, +2 authors, Chapla Agarwal.
Neoplasia, 2010 Jan 15; 12(1). PMID: 20072658    Free PMC article.
Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction.
Ying Wang, Yu Fu, +8 authors, Wei Wu.
J Biol Chem, 2010 Jan 28; 285(14). PMID: 20103590    Free PMC article.
CK1epsilon is required for breast cancers dependent on beta-catenin activity.
So Young Kim, Ian F Dunn, +11 authors, William C Hahn.
PLoS One, 2010 Feb 04; 5(2). PMID: 20126544    Free PMC article.
Neurofilament heavy polypeptide regulates the Akt-beta-catenin pathway in human esophageal squamous cell carcinoma.
Myoung Sook Kim, Xiaofei Chang, +7 authors, David Sidransky.
PLoS One, 2010 Feb 09; 5(2). PMID: 20140245    Free PMC article.
JC virus in the pathogenesis of colorectal cancer, an etiological agent or another component in a multistep process?
Tatiana R Coelho, Luis Almeida, Pedro A Lazo.
Virol J, 2010 Feb 20; 7. PMID: 20167111    Free PMC article.
Review.
High frequency of beta-catenin heterozygous mutations in extra-abdominal fibromatosis: a potential molecular tool for disease management.
J Dômont, S Salas, +15 authors, J Bénard.
Br J Cancer, 2010 Mar 04; 102(6). PMID: 20197769    Free PMC article.
Striking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progression.
Tura C Camilli, Ashani T Weeraratna.
Biochem Pharmacol, 2010 Mar 10; 80(5). PMID: 20211149    Free PMC article.
Review.
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical Wnt signaling and C/EBP.
Weimin Qiu, Yuhui Hu, +4 authors, Moustapha Kassem.
J Biol Chem, 2010 Mar 13; 285(19). PMID: 20223822    Free PMC article.
NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem cell transplantation unrelated to graft-versus-tumor effects: state of the science.
Mitchell S Cairo, Craig T Jordan, +11 authors, Carl H June.
Biol Blood Marrow Transplant, 2010 Mar 17; 16(6). PMID: 20227509    Free PMC article.
Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations.
Mandayam O Nandan, Amr M Ghaleb, +3 authors, Vincent W Yang.
Mol Cancer, 2010 Mar 20; 9. PMID: 20298593    Free PMC article.
Secreted frizzled-related protein-5 is epigenetically downregulated and functions as a tumor suppressor in kidney cancer.
Kazumori Kawakami, Soichiro Yamamura, +8 authors, Rajvir Dahiya.
Int J Cancer, 2010 Mar 27; 128(3). PMID: 20340127    Free PMC article.
Germinated brown rice (GBR) reduces the incidence of aberrant crypt foci with the involvement of beta-catenin and COX-2 in azoxymethane-induced colon cancer in rats.
Saiful Yazan Latifah, Nurdin Armania, +6 authors, Ismail Maznah.
Nutr J, 2010 Mar 30; 9. PMID: 20346115    Free PMC article.
AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552.
Junxing Zhao, Wanfu Yue, +2 authors, Min Du.
Biochem Biophys Res Commun, 2010 Apr 07; 395(1). PMID: 20361929    Free PMC article.
Beta-catenin/TCF4 transactivates miR-30e during intestinal cell differentiation.
Y Liao, B Lönnerdal.
Cell Mol Life Sci, 2010 Apr 08; 67(17). PMID: 20372961    Free PMC article.
A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation.
Taranjit S Gujral, Gavin MacBeath.
PLoS One, 2010 Apr 13; 5(4). PMID: 20383323    Free PMC article.
Disruption of the non-canonical WNT pathway in lung squamous cell carcinoma.
Eric H L Lee, Raj Chari, +7 authors, Wan L Lam.
Clin Med Oncol, 2008 Apr 01; 2008(2). PMID: 20401333    Free PMC article.
Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death.
Mellone N Marchong, Christine Yurkowski, +3 authors, Brenda L Gallie.
PLoS Genet, 2010 Apr 28; 6(4). PMID: 20421947    Free PMC article.
Sex modulates intestinal transformation by the tumor-suppressor GCC.
Peng Li, Stephanie Schulz, Giovanni M Pitari, Scott A Waldman.
Clin Transl Sci, 2008 Sep 01; 1(2). PMID: 20443837    Free PMC article.
Sex modulates intestinal transformation by the tumor-suppressor GCC.
Peng Li, Stephanie Schulz, Giovanni M Pitari, Scott A Waldman.
Clin Transl Sci, 2008 Sep 01; 1(2). PMID: 20443838    Free PMC article.
Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin signaling.
Shibani Pati, Aarif Y Khakoo, +11 authors, Pramod K Dash.
Stem Cells Dev, 2010 May 08; 20(1). PMID: 20446815    Free PMC article.
Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling.
Manjinder Kaur, Balaiya Velmurugan, +3 authors, Rajesh Agarwal.
Neoplasia, 2010 May 11; 12(5). PMID: 20454513    Free PMC article.
Identification of {beta}-catenin binding regions in colon cancer cells using ChIP-Seq.
Daniel Bottomly, Sydney L Kyler, Shannon K McWeeney, Gregory S Yochum.
Nucleic Acids Res, 2010 May 13; 38(17). PMID: 20460455    Free PMC article.
Adenomatous polyposis coli regulates endothelial cell migration independent of roles in beta-catenin signaling and cell-cell adhesion.
Elizabeth S Harris, W James Nelson.
Mol Biol Cell, 2010 Jun 04; 21(15). PMID: 20519433    Free PMC article.
A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer.
Noriko N Yokoyama, Kira T Pate, Stephanie Sprowl, Marian L Waterman.
Nucleic Acids Res, 2010 Jun 08; 38(19). PMID: 20525792    Free PMC article.
Oncogenic mutations of PIK3CA in human cancers.
Yardena Samuels, Todd Waldman.
Curr Top Microbiol Immunol, 2010 Jun 11; 347. PMID: 20535651    Free PMC article.
Review.
Molecular imaging of glycogen synthase kinase-3beta and casein kinase-1alpha kinases.
Shyam Nyati, Rajesh Ranga, +2 authors, Mahaveer Swaroop Bhojani.
Anal Biochem, 2010 Jun 22; 405(2). PMID: 20561505    Free PMC article.
EpCAM nuclear localization identifies aggressive thyroid cancer and is a marker for poor prognosis.
Ranju Ralhan, Jun Cao, +3 authors, Paul G Walfish.
BMC Cancer, 2010 Jun 29; 10. PMID: 20579375    Free PMC article.
Corruption of homeostatic mechanisms in the guanylyl cyclase C signaling pathway underlying colorectal tumorigenesis.
Peng Li, Scott A Waldman.
Cancer Biol Ther, 2010 Jul 02; 10(3). PMID: 20592492    Free PMC article.
Review.
A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.
Kenneth Ewan, Bozena Pajak, +17 authors, Trevor Dale.
Cancer Res, 2010 Jul 09; 70(14). PMID: 20610623    Free PMC article.
Wnt signalling in adenomas of familial adenomatous polyposis patients.
G M Caldwell, C E Jones, +4 authors, G M Matthews.
Br J Cancer, 2010 Jul 16; 103(6). PMID: 20628379    Free PMC article.
Pinin modulates expression of an intestinal homeobox gene, Cdx2, and plays an essential role for small intestinal morphogenesis.
Jeong-Hoon Joo, Timothy J Taxter, +6 authors, Stephen P Sugrue.
Dev Biol, 2010 Jul 20; 345(2). PMID: 20637749    Free PMC article.
Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair.
Aimin Li, Yiming Xing, +5 authors, Changgong Li.
Dev Dyn, 2010 Jul 27; 239(8). PMID: 20658693    Free PMC article.
Tian Xian Liquid (TXL) induces apoptosis in HT-29 colon cancer cell in vitro and inhibits tumor growth in vivo.
Qing Liu, Yao Tong, +4 authors, Christine Miu Ngan Yow.
Chin Med, 2010 Jul 29; 5. PMID: 20663169    Free PMC article.
Approach to early-onset colorectal cancer: clinicopathological, familial, molecular and immunohistochemical characteristics.
Jose Perea, Edurne Alvaro, +8 authors, Miguel Urioste.
World J Gastroenterol, 2010 Aug 03; 16(29). PMID: 20677343    Free PMC article.
The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres.
Shailender S Kanwar, Yingjie Yu, +2 authors, Adhip P N Majumdar.
Mol Cancer, 2010 Aug 10; 9. PMID: 20691072    Free PMC article.
Highly Cited.
Mutations in the WTX-gene are found in some high-grade microsatellite instable (MSI-H) colorectal cancers.
Silvio K Scheel, Marc Porzner, +3 authors, Andreas Jung.
BMC Cancer, 2010 Aug 11; 10. PMID: 20696052    Free PMC article.
Positive feedback regulation between phospholipase D and Wnt signaling promotes Wnt-driven anchorage-independent growth of colorectal cancer cells.
Dong Woo Kang, Do Sik Min.
PLoS One, 2010 Aug 17; 5(8). PMID: 20711340    Free PMC article.
Selective cyclooxygenase-2 silencing mediated by engineered E. coli and RNA interference induces anti-tumour effects in human colon cancer cells.
A Strillacci, C Griffoni, +7 authors, E Spisni.
Br J Cancer, 2010 Aug 19; 103(7). PMID: 20717114    Free PMC article.
The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine.
Songbai Lin, Sei-Jung Lee, +2 authors, C Chris Yun.
Am J Physiol Gastrointest Liver Physiol, 2010 Aug 21; 299(5). PMID: 20724530    Free PMC article.
Specific targeting of Wnt/β-catenin signaling in human melanoma cells by a dietary triterpene lupeol.
Rohinton S Tarapore, Imtiaz A Siddiqui, +3 authors, Hasan Mukhtar.
Carcinogenesis, 2010 Aug 25; 31(10). PMID: 20732907    Free PMC article.
Formation of extra centrosomal structures is dependent on beta-catenin.
Shirin Bahmanyar, Evan L Guiney, +2 authors, Angela I M Barth.
J Cell Sci, 2010 Aug 26; 123(Pt 18). PMID: 20736306    Free PMC article.
Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria.
Lidia Hernandez, Kyle J Roux, +18 authors, Colin L Stewart.
Dev Cell, 2010 Sep 14; 19(3). PMID: 20833363    Free PMC article.
Role of Wnt canonical pathway in hematological malignancies.
Xueling Ge, Xin Wang.
J Hematol Oncol, 2010 Sep 17; 3. PMID: 20843302    Free PMC article.
Review.
Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active β-catenin.
E Lavergne, I Hendaoui, +7 authors, O Musso.
Oncogene, 2010 Sep 22; 30(4). PMID: 20856206    Free PMC article.
Association of nuclear localization of a long interspersed nuclear element-1 protein in breast tumors with poor prognostic outcomes.
Chris R Harris, Robin Normart, +6 authors, Laura H Tang.
Genes Cancer, 2010 Oct 16; 1(2). PMID: 20948976    Free PMC article.
Mammalian Krüppel-like factors in health and diseases.
Beth B McConnell, Vincent W Yang.
Physiol Rev, 2010 Oct 21; 90(4). PMID: 20959618    Free PMC article.
Highly Cited. Review.
p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium.
Alicia M Cole, Rachel A Ridgway, +5 authors, Owen J Sansom.
EMBO Mol Med, 2010 Oct 27; 2(11). PMID: 20976827    Free PMC article.
Diverse mechanisms of Wnt activation and effects of pathway inhibition on proliferation of human gastric carcinoma cells.
S Asciutti, G Akiri, +2 authors, S A Aaronson.
Oncogene, 2010 Nov 03; 30(8). PMID: 21042278    Free PMC article.
Black raspberries inhibit intestinal tumorigenesis in apc1638+/- and Muc2-/- mouse models of colorectal cancer.
Xiuli Bi, Wenfeng Fang, +2 authors, Wancai Yang.
Cancer Prev Res (Phila), 2010 Nov 04; 3(11). PMID: 21045162    Free PMC article.
Regulation of gene expression in the intestinal epithelium.
Camilla A Richmond, David T Breault.
Prog Mol Biol Transl Sci, 2010 Nov 16; 96. PMID: 21075346    Free PMC article.
Review.
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis.
Tokameh Mahmoudi, Sylvia F Boj, +9 authors, Hans Clevers.
PLoS Biol, 2010 Nov 26; 8(11). PMID: 21103407    Free PMC article.
Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation.
Rita U Lukacs, Sanaz Memarzadeh, Hong Wu, Owen N Witte.
Cell Stem Cell, 2010 Nov 30; 7(6). PMID: 21112563    Free PMC article.
Highly Cited.
Targeting the oncogenic protein beta-catenin to enhance chemotherapy outcome against solid human cancers.
Maher S Saifo, Donald R Rempinski, Youcef M Rustum, Rami G Azrak.
Mol Cancer, 2010 Dec 04; 9. PMID: 21126356    Free PMC article.
Deranged Wnt signaling is frequent in hereditary nonpolyposis colorectal cancer.
Anna Isinger-Ekstrand, Christina Therkildsen, Inge Bernstein, Mef Nilbert.
Fam Cancer, 2010 Dec 07; 10(2). PMID: 21132538
Identification of PP2A complexes and pathways involved in cell transformation.
Anna A Sablina, Melissa Hector, Nathalie Colpaert, William C Hahn.
Cancer Res, 2010 Dec 17; 70(24). PMID: 21159657    Free PMC article.
Anti-carcinogenic properties of curcumin on colorectal cancer.
Jung Park, Chris N Conteas.
World J Gastrointest Oncol, 2010 Dec 17; 2(4). PMID: 21160593    Free PMC article.
Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer.
Yoku Hayakawa, Yoshihiro Hirata, +14 authors, Kazuhiko Koike.
Proc Natl Acad Sci U S A, 2010 Dec 29; 108(2). PMID: 21187402    Free PMC article.
Colon cancer stem cells: implications in carcinogenesis.
Matthew A Sanders, Adhip P N Majumdar.
Front Biosci (Landmark Ed), 2011 Jan 05; 16. PMID: 21196254    Free PMC article.
Review.
Layers of epistasis: genome-wide regulatory networks and network approaches to genome-wide association studies.
Richard Cowper-Sal lari, Michael D Cole, +2 authors, Jason H Moore.
Wiley Interdiscip Rev Syst Biol Med, 2011 Jan 05; 3(5). PMID: 21197657    Free PMC article.
Review.
Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substrates.
Ya-Li Yao, Wen-Ming Yang.
J Biomed Biotechnol, 2011 Jan 15; 2011. PMID: 21234400    Free PMC article.
Review.
Wnt signaling in estrogen-induced lactotroph proliferation.
Adam Giles, Frederic Madec, +6 authors, Julian R E Davis.
J Cell Sci, 2011 Jan 20; 124(Pt 4). PMID: 21245194    Free PMC article.
Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin.
Marc Fiedler, Carolina Mendoza-Topaz, +2 authors, Mariann Bienz.
Proc Natl Acad Sci U S A, 2011 Jan 20; 108(5). PMID: 21245303    Free PMC article.
Highly Cited.
IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2.
Perry S Mongroo, Felicite K Noubissi, +7 authors, Anil K Rustgi.
Cancer Res, 2011 Jan 22; 71(6). PMID: 21252116    Free PMC article.
Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats.
Martina Perše, Anton Cerar.
J Biomed Biotechnol, 2011 Jan 22; 2011. PMID: 21253581    Free PMC article.
Review.
Enteric bacteria and cancer stem cells.
Jun Sun.
Cancers (Basel), 2011 Feb 08; 3(1). PMID: 21297903    Free PMC article.
Drug discovery approaches to target Wnt signaling in cancer stem cells.
Joshua C Curtin, Matthew V Lorenzi.
Oncotarget, 2011 Feb 15; 1(7). PMID: 21317452    Free PMC article.
Highly Cited. Review.
Targeting metabolic remodeling in glioblastoma multiforme.
Amparo Wolf, Sameer Agnihotri, Abhijit Guha.
Oncotarget, 2011 Feb 15; 1(7). PMID: 21317451    Free PMC article.
Review.
HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression.
Y Li, J H Bavarva, +5 authors, W Liu.
Oncogene, 2011 Feb 15; 30(23). PMID: 21317929    Free PMC article.
Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling.
Keli Kolegraff, Porfirio Nava, +2 authors, Asma Nusrat.
Mol Biol Cell, 2011 Feb 18; 22(8). PMID: 21325624    Free PMC article.
Expression of osteopontin coregulators in primary colorectal cancer and associated liver metastases.
D J Mole, C O'Neill, +6 authors, F C Campbell.
Br J Cancer, 2011 Feb 24; 104(6). PMID: 21343932    Free PMC article.
Transcriptional characterization of Wnt and Notch signaling pathways in neuronal differentiation of human adipose tissue-derived stem cells.
Alejandra Johana Cardozo, Daniel Eduardo Gómez, Pablo Francisco Argibay.
J Mol Neurosci, 2011 Mar 02; 44(3). PMID: 21360053
Effect of different resistance-training regimens on the WNT-signaling pathway.
Marcelo Larciprete Leal, Leonardo Lamas, +4 authors, Anselmo Sigari Moriscot.
Eur J Appl Physiol, 2011 Mar 03; 111(10). PMID: 21365345
The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling.
Tony T H Lui, Celine Lacroix, +4 authors, Stephane Angers.
Mol Cell Biol, 2011 Mar 09; 31(10). PMID: 21383061    Free PMC article.
Mutated beta-catenin evades a microRNA-dependent regulatory loop.
Angelo Veronese, Rosa Visone, +14 authors, Carlo M Croce.
Proc Natl Acad Sci U S A, 2011 Mar 09; 108(12). PMID: 21383185    Free PMC article.
Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer.
Holly Symolon, Anatoliy Bushnev, +8 authors, Alfred H Merrill.
Mol Cancer Ther, 2011 Mar 15; 10(4). PMID: 21398423    Free PMC article.
Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cells.
Bhavatarini Vangamudi, Shoumin Zhu, +2 authors, Wael El-Rifai.
Mol Cancer, 2011 Mar 31; 10. PMID: 21447180    Free PMC article.
Colon cancer stem cells.
Feras J Abdul Khalek, G Ian Gallicano, Lopa Mishra.
Gastrointest Cancer Res, 2011 Apr 08; (Suppl 1). PMID: 21472043    Free PMC article.
The Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways.
Michael Bordonaro, Shruti Tewari, Wafa Atamna, Darina L Lazarova.
Exp Cell Res, 2011 Apr 09; 317(10). PMID: 21473864    Free PMC article.
The Association of Beta-catenin Gene Mutations and Human Papillomavirus in Carcinoma of Esophagus in a High-Risk Population of India.
Mohammad Muzaffar Mir, Javid Ahmad Dar, +3 authors, Ghulam Nabi Lone.
Int J Health Sci (Qassim), 2007 Jul 01; 1(2). PMID: 21475426    Free PMC article.
Wnt signaling and colon carcinogenesis: beyond APC.
Rani Najdi, Randall F Holcombe, Marian L Waterman.
J Carcinog, 2011 Apr 13; 10. PMID: 21483657    Free PMC article.
Highly Cited.
INPP4B: the new kid on the PI3K block.
Irina U Agoulnik, Myles C Hodgson, Wayne A Bowden, Michael M Ittmann.
Oncotarget, 2011 Apr 14; 2(4). PMID: 21487159    Free PMC article.
Review.
Wnt/β-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells.
Felipe Nuñez, Soraya Bravo, +2 authors, Giancarlo V De Ferrari.
PLoS One, 2011 Apr 16; 6(4). PMID: 21494638    Free PMC article.
DNA methylation predicts recurrence from resected stage III proximal colon cancer.
Joong Bae Ahn, Woon Bok Chung, +5 authors, Jean-Pierre J Issa.
Cancer, 2011 Apr 22; 117(9). PMID: 21509761    Free PMC article.
Pharmacogenomics and cancer stem cells: a changing landscape?
Francesco Crea, Maria Ana Duhagon, William L Farrar, Romano Danesi.
Trends Pharmacol Sci, 2011 May 03; 32(8). PMID: 21529973    Free PMC article.
Review.
WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways.
Giovanna Nalesso, Joanna Sherwood, +5 authors, Francesco Dell'accio.
J Cell Biol, 2011 May 04; 193(3). PMID: 21536751    Free PMC article.
Colorectal Cancer Stem Cells: Biology and Therapeutic Implications.
Brian J Wilson, Tobias Schatton, Markus H Frank, Natasha Y Frank.
Curr Colorectal Cancer Rep, 2011 May 10; 7(2). PMID: 21552371    Free PMC article.
Apoptosis inducing effect of plumbagin on colonic cancer cells depends on expression of COX-2.
Bharathi Raja Subramaniya, Gayathri Srinivasan, +4 authors, Niranjali Devaraj Sivasitambaram.
PLoS One, 2011 May 12; 6(4). PMID: 21559086    Free PMC article.
High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A.
Sapna Vijayakumar, Guizhong Liu, +5 authors, Stuart A Aaronson.
Cancer Cell, 2011 May 18; 19(5). PMID: 21575861    Free PMC article.
Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing.
Kirsten A Bielefeld, Saeid Amini-Nik, +4 authors, Benjamin A Alman.
J Biol Chem, 2011 Jun 10; 286(31). PMID: 21652705    Free PMC article.
Wnt and hedgehog gene pathway expression in serous ovarian cancer.
Seraina Schmid, Marcia Bieber, +4 authors, Nelson N H Teng.
Int J Gynecol Cancer, 2011 Jun 15; 21(6). PMID: 21666490    Free PMC article.
Nuclear translocation of β-catenin correlates with CD44 upregulation in Helicobacter pylori-infected gastric carcinoma.
Gopal Udhayakumar, Venkatraman Jayanthi, Niranjali Devaraj, Halagowder Devaraj.
Mol Cell Biochem, 2011 Jun 17; 357(1-2). PMID: 21678082
Prognostic significance of Wnt-1, β-catenin and E-cadherin expression in advanced colorectal carcinoma.
Aleksandra Stanczak, Rafal Stec, +7 authors, Monika Lamparska-Przybysz.
Pathol Oncol Res, 2011 Jun 17; 17(4). PMID: 21678109    Free PMC article.
Cisplatin and TRAIL enhance breast cancer stem cell death.
Shuping Yin, Liping Xu, +2 authors, Kaladhar B Reddy.
Int J Oncol, 2011 Jun 21; 39(4). PMID: 21687939    Free PMC article.
Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors.
Andreas Lorenz, Markus Deutschmann, +6 authors, Ulrich Schüller.
Mol Cell Biol, 2011 Jun 22; 31(16). PMID: 21690300    Free PMC article.
Altered intracellular localization and mobility of SBDS protein upon mutation in Shwachman-Diamond syndrome.
Claudia Orelio, Renée M van der Sluis, +4 authors, Taco W Kuijpers.
PLoS One, 2011 Jun 23; 6(6). PMID: 21695142    Free PMC article.
Intestinal carcinogenesis: IKK can go all the way.
Yoshiaki Sunami, Thomas Wirth.
J Clin Invest, 2011 Jun 28; 121(7). PMID: 21701071    Free PMC article.
Enormous influence of TNIK knockdown on intracellular signals and cell survival.
Jinghua Gui, Baotian Yang, Jinyun Wu, Xiumei Zhou.
Hum Cell, 2011 Jun 29; 24(3). PMID: 21710359
Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma.
Junfang Ji, Taro Yamashita, Xin W Wang.
Cell Biosci, 2011 Jun 30; 1(1). PMID: 21711587    Free PMC article.
Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab.
Lori S Hart, Nathan G Dolloff, +4 authors, Wafik S El-Deiry.
Cell Cycle, 2011 Jul 02; 10(14). PMID: 21720213    Free PMC article.
Current progress of siRNA/shRNA therapeutics in clinical trials.
John C Burnett, John J Rossi, Katrin Tiemann.
Biotechnol J, 2011 Jul 12; 6(9). PMID: 21744502    Free PMC article.
Highly Cited. Review.
Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.
Claire M Payne, Cheray Crowley-Skillicorn, +2 authors, Harris Bernstein.
Clin Exp Gastroenterol, 2011 Jul 15; 4. PMID: 21753893    Free PMC article.
CTNNB1 gene mutations, pituitary transcription factors, and MicroRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas.
Marina Lanciotti Campanini, Leandro Machado Colli, +8 authors, Margaret de Castro.
Horm Cancer, 2010 Jan 01; 1(4). PMID: 21761366
Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells.
Seong-Ho Lee, Raphael L Richardson, Roderick H Dashwood, Seung Joon Baek.
J Nutr Biochem, 2011 Jul 19; 23(6). PMID: 21764279    Free PMC article.
Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/β-catenin/cyclin D1 signaling pathway in rats.
Nanjoo Suh, Bandaru S Reddy, +9 authors, Chinthalapally V Rao.
Cancer Prev Res (Phila), 2011 Jul 19; 4(11). PMID: 21764859    Free PMC article.
Clinicopathological significance of E-cadherin, β-catenin and p53 expression in gastric adenocarinoma.
Mohammad Reza Zali, Omeed Moaven, +5 authors, Mohammad Reza Abbaszadegan.
J Res Med Sci, 2009 Jul 01; 14(4). PMID: 21772890    Free PMC article.
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
Maria-Magdalena Georgescu.
Genes Cancer, 2011 Jul 23; 1(12). PMID: 21779440    Free PMC article.
Highly Cited.
The genomics of lung adenocarcinoma: opportunities for targeted therapies.
Heidi Greulich.
Genes Cancer, 2011 Jul 23; 1(12). PMID: 21779443    Free PMC article.
Wnt/β-catenin Pathway Modulates the Sensitivity of the Mutant FLT3 Receptor Kinase Inhibitors in a GSK-3β Dependent Manner.
Jingrui Jiang, James D Griffin.
Genes Cancer, 2010 Feb 01; 1(2). PMID: 21779446    Free PMC article.
Enhanced suicidal erythrocyte death in mice carrying a loss-of-function mutation of the adenomatous polyposis coli gene.
Syed M Qadri, Hasan Mahmud, +7 authors, Florian Lang.
J Cell Mol Med, 2011 Jul 26; 16(5). PMID: 21781276    Free PMC article.
Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population.
A Syed Sameer, Zaffar A Shah, +2 authors, Mushtaq A Siddiqi.
Hum Genomics, 2011 Aug 03; 5(5). PMID: 21807601    Free PMC article.
LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines.
Francesca Walker, Hui-Hua Zhang, Annalisa Odorizzi, Antony W Burgess.
PLoS One, 2011 Aug 11; 6(7). PMID: 21829496    Free PMC article.
[Non-serrated precursor lesions of colorectal tumours].
C Langner.
Pathologe, 2011 Aug 17; 32 Suppl 2. PMID: 21845358
Review.
Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein.
Zhenyi Zhang, Hua Li, +5 authors, Geng Wu.
PLoS One, 2011 Aug 23; 6(8). PMID: 21858148    Free PMC article.
Cross talk between focal adhesion kinase and cadherins: role in regulating endothelial barrier function.
Sadiqa K Quadri.
Microvasc Res, 2011 Aug 26; 83(1). PMID: 21864544    Free PMC article.
Review.
The beta-catenin binding protein ICAT modulates androgen receptor activity.
Ming Zhuo, Chunfang Zhu, +2 authors, Zijie Sun.
Mol Endocrinol, 2011 Sep 03; 25(10). PMID: 21885566    Free PMC article.
Normal morphogenesis of epithelial tissues and progression of epithelial tumors.
Chun-Chao Wang, Leen Jamal, Kevin A Janes.
Wiley Interdiscip Rev Syst Biol Med, 2011 Sep 08; 4(1). PMID: 21898857    Free PMC article.
Review.
Readthrough of premature termination codons in the adenomatous polyposis coli gene restores its biological activity in human cancer cells.
Célia Floquet, Jean-Pierre Rousset, Laure Bidou.
PLoS One, 2011 Sep 13; 6(8). PMID: 21909382    Free PMC article.
Aloe vera non-decolorized whole leaf extract-induced large intestinal tumors in F344 rats share similar molecular pathways with human sporadic colorectal tumors.
Arun R Pandiri, Robert C Sills, +9 authors, Mary D Boudreau.
Toxicol Pathol, 2011 Sep 23; 39(7). PMID: 21937742    Free PMC article.
The dual role of sirtuins in cancer.
Laia Bosch-Presegué, Alejandro Vaquero.
Genes Cancer, 2011 Sep 24; 2(6). PMID: 21941620    Free PMC article.
Highly Cited.
Radiofrequency ablation for dysplasia in Barrett's esophagus restores β-catenin activation within esophageal progenitor cells.
K Krishnan, S Komanduri, +6 authors, T A Barrett.
Dig Dis Sci, 2011 Sep 29; 57(2). PMID: 21948356
Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling.
Alix Scholer-Dahirel, Michael R Schlabach, +15 authors, Margaret E McLaughlin.
Proc Natl Acad Sci U S A, 2011 Sep 29; 108(41). PMID: 21949247    Free PMC article.
Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.
Naoshi Nishida, Ajay Goel.
Curr Genomics, 2011 Oct 04; 12(2). PMID: 21966251    Free PMC article.
The C-terminus of Apc does not influence intestinal adenoma development or progression.
Annabelle Lewis, Hayley Davis, +9 authors, Ian Tomlinson.
J Pathol, 2011 Oct 20; 226(1). PMID: 22009253    Free PMC article.
Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions.
Jianming Wu, Maureen H Richards, +7 authors, Robert P Kimberly.
PLoS One, 2011 Oct 25; 6(10). PMID: 22022540    Free PMC article.
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition.
Nam Hee Kim, Hyun Sil Kim, +12 authors, Jong In Yook.
J Cell Biol, 2011 Oct 26; 195(3). PMID: 22024162    Free PMC article.
Highly Cited.
Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance.
Dawang Zhou, Yongyou Zhang, +8 authors, Joseph Avruch.
Proc Natl Acad Sci U S A, 2011 Nov 02; 108(49). PMID: 22042863    Free PMC article.
Highly Cited.
p53 and microRNA-34 are suppressors of canonical Wnt signaling.
Nam Hee Kim, Hyun Sil Kim, +13 authors, Stephen J Weiss.
Sci Signal, 2011 Nov 03; 4(197). PMID: 22045851    Free PMC article.
Highly Cited.
Chemoprevention of familial adenomatous polyposis by bromo-noscapine (EM011) in the Apc(Min/+) mouse model.
Shiwang Li, Amr M Ghaleb, +4 authors, Harish C Joshi.
Int J Cancer, 2011 Nov 05; 131(6). PMID: 22052467    Free PMC article.
MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFβR2) in colon cancer cells.
Yingjie Yu, Shailender S Kanwar, +4 authors, Adhip P N Majumdar.
Carcinogenesis, 2011 Nov 11; 33(1). PMID: 22072622    Free PMC article.
Highly Cited.
A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells.
Michael Bordonaro, Shruti Tewari, +2 authors, Darina L Lazarova.
PLoS One, 2011 Nov 11; 6(11). PMID: 22073312    Free PMC article.
Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway.
Masaaki Nishiyama, Arthur I Skoultchi, Keiichi I Nakayama.
Mol Cell Biol, 2011 Nov 16; 32(2). PMID: 22083958    Free PMC article.
Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia.
H-A Hou, Y-Y Kuo, +9 authors, H-F Tien.
Br J Cancer, 2011 Nov 19; 105(12). PMID: 22095226    Free PMC article.
Molecular pathogenesis of endometrial and ovarian cancer.
Melissa A Merritt, Daniel W Cramer.
Cancer Biomark, 2011 Nov 25; 9(1-6). PMID: 22112481    Free PMC article.
Review.
Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin.
Tanner J Freeman, J Joshua Smith, +7 authors, R Daniel Beauchamp.
Gastroenterology, 2011 Nov 26; 142(3). PMID: 22115830    Free PMC article.
Tazarotene-induced gene 1 inhibits prostaglandin E2-stimulated HCT116 colon cancer cell growth.
Fu-Ming Tsai, Chang-Chieh Wu, +2 authors, Shun-Yuan Jiang.
J Biomed Sci, 2011 Dec 01; 18. PMID: 22126303    Free PMC article.
Sp1 expression regulates lung tumor progression.
T-I Hsu, M-C Wang, +4 authors, J-J Hung.
Oncogene, 2011 Dec 14; 31(35). PMID: 22158040    Free PMC article.
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.
Jian Wu, Yuchen Jiao, +25 authors, Bert Vogelstein.
Proc Natl Acad Sci U S A, 2011 Dec 14; 108(52). PMID: 22158988    Free PMC article.
Highly Cited.
Modulation of Wnt/β-catenin signaling pathway by bioactive food components.
Rohinton S Tarapore, Imtiaz A Siddiqui, Hasan Mukhtar.
Carcinogenesis, 2011 Dec 27; 33(3). PMID: 22198211    Free PMC article.
Review.
Epigenetic and genetic analysis of WNT signaling pathway in sporadic colorectal cancer patients from Iran.
Fakhraddin Naghibalhossaini, Mozhdeh Zamani, +3 authors, Zohreh Mostafavi-Pour.
Mol Biol Rep, 2011 Dec 31; 39(5). PMID: 22207181
MicroRNA-200a suppresses the Wnt/β-catenin signaling pathway by interacting with β-catenin.
Juan Su, Anling Zhang, +6 authors, Qingyu Zhang.
Int J Oncol, 2012 Jan 03; 40(4). PMID: 22211245    Free PMC article.
A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins.
Katrin Luckert, Taranjit S Gujral, +5 authors, Oliver Pötz.
Sci Signal, 2012 Jan 12; 5(206). PMID: 22234610    Free PMC article.
XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.
Alison J Hanson, Heather A Wallace, +3 authors, Ethan Lee.
Mol Cell, 2012 Feb 07; 45(5). PMID: 22304967    Free PMC article.
Differential WNT activity in colorectal cancer confers limited tumorigenic potential and is regulated by MAPK signaling.
David Horst, Justina Chen, +3 authors, Ramesh A Shivdasani.
Cancer Res, 2012 Feb 10; 72(6). PMID: 22318865    Free PMC article.
Wnt signaling pathways in urological cancers: past decades and still growing.
Shahana Majid, Sharanjot Saini, Rajvir Dahiya.
Mol Cancer, 2012 Feb 14; 11. PMID: 22325146    Free PMC article.
Review.
Regulation of colon cancer recurrence and development of therapeutic strategies.
Shailender Singh Kanwar, Anuradha Poolla, Adhip Pn Majumdar.
World J Gastrointest Pathophysiol, 2012 Mar 01; 3(1). PMID: 22368781    Free PMC article.
Regulation of the DLG tumor suppressor by β-catenin.
Vanitha Krishna Subbaiah, Nisha Narayan, Paola Massimi, Lawrence Banks.
Int J Cancer, 2012 Mar 07; 131(10). PMID: 22392736    Free PMC article.
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal.
Johan H van Es, Andrea Haegebarth, +8 authors, Hans Clevers.
Mol Cell Biol, 2012 Mar 07; 32(10). PMID: 22393260    Free PMC article.
Highly Cited.
Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue.
Meina Wang, Dezhi Tang, +13 authors, Di Chen.
Arthritis Rheum, 2012 Mar 17; 64(8). PMID: 22422036    Free PMC article.
DNAJB6 governs a novel regulatory loop determining Wnt/β-catenin signalling activity.
Mitchell E Menezes, Aparna Mitra, Lalita A Shevde, Rajeev S Samant.
Biochem J, 2012 Mar 30; 444(3). PMID: 22455953    Free PMC article.
Impact of mutant β-catenin on ABCB1 expression and therapy response in colon cancer cells.
U Stein, C Fleuter, +7 authors, W Walther.
Br J Cancer, 2012 Mar 31; 106(8). PMID: 22460269    Free PMC article.
In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system.
T Jardé, R J Evans, +5 authors, T C Dale.
Oncogene, 2012 Apr 04; 32(7). PMID: 22469981    Free PMC article.
Oncogenic function of DACT1 in colon cancer through the regulation of β-catenin.
Guohong Yuan, Chongkai Wang, +4 authors, Wei Fu.
PLoS One, 2012 Apr 04; 7(3). PMID: 22470507    Free PMC article.
Wnt signaling, stem cells, and cancer of the gastrointestinal tract.
Arnout Schepers, Hans Clevers.
Cold Spring Harb Perspect Biol, 2012 Apr 05; 4(4). PMID: 22474007    Free PMC article.
Plakoglobin: role in tumorigenesis and metastasis.
Zackie Aktary, Manijeh Pasdar.
Int J Cell Biol, 2012 Apr 07; 2012. PMID: 22481945    Free PMC article.
Mechanism of β-catenin-mediated transcriptional regulation of epidermal growth factor receptor expression in glycogen synthase kinase 3 β-inactivated prostate cancer cells.
Kiran Kumar Naidu Guturi, Tapashi Mandal, +4 authors, Mrinal K Ghosh.
J Biol Chem, 2012 Apr 12; 287(22). PMID: 22493441    Free PMC article.
Racemization of two proteins over our lifespan: deamidation of asparagine 76 in γS crystallin is greater in cataract than in normal lenses across the age range.
Michelle Yu Sung Hooi, Mark J Raftery, Roger John Willis Truscott.
Invest Ophthalmol Vis Sci, 2012 Apr 26; 53(7). PMID: 22531704    Free PMC article.
Genetic alterations in colorectal cancer.
Tannaz Armaghany, Jon D Wilson, Quyen Chu, Glenn Mills.
Gastrointest Cancer Res, 2012 May 11; 5(1). PMID: 22574233    Free PMC article.
Highly Cited.
MENA is a transcriptional target of the Wnt/beta-catenin pathway.
Ayaz Najafov, Tuncay Seker, +5 authors, Necla Birgül-İyison.
PLoS One, 2012 May 23; 7(5). PMID: 22615875    Free PMC article.
Three decades of Wnts: a personal perspective on how a scientific field developed.
Roel Nusse, Harold Varmus.
EMBO J, 2012 May 24; 31(12). PMID: 22617420    Free PMC article.
Highly Cited. Review.
Drugging Wnt signalling in cancer.
Paul Polakis.
EMBO J, 2012 May 24; 31(12). PMID: 22617421    Free PMC article.
Highly Cited. Review.
Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins.
Jurian Schuijers, Hans Clevers.
EMBO J, 2012 May 24; 31(12). PMID: 22617424    Free PMC article.
Highly Cited. Review.
Mitotic and mitogenic Wnt signalling.
Christof Niehrs, Sergio P Acebron.
EMBO J, 2012 May 24; 31(12). PMID: 22617425    Free PMC article.
Highly Cited. Review.
Chibby suppresses growth of human SW480 colon adenocarcinoma cells through inhibition of β-catenin signaling.
Victoria Fischer, Dex-Ann Brown-Grant, Feng-Qian Li.
J Mol Signal, 2012 Jun 02; 7(1). PMID: 22651859    Free PMC article.
Multiplexed protein signal pathway mapping identifies patients with rectal cancer that responds to neoadjuvant treatment.
Enzo Mammano, Francesca Galdi, +12 authors, Donato Nitti.
Clin Colorectal Cancer, 2012 Jun 05; 11(4). PMID: 22658458    Free PMC article.
Divergent regulation of Wnt-mediated development of the dorsomedial and ventrolateral dermomyotomal lips.
Stefanie Krück, Martin Scaal.
Histochem Cell Biol, 2012 Jun 07; 138(3). PMID: 22669461
Wolfberry Water Soluble Phytochemicals Down-Regulate ER Stress Biomarkers and Modulate Multiple Signaling Pathways Leading To Inhibition of Proliferation and Induction of Apoptosis in Jurkat Cells.
Yu Jiang, Yunong Zhang, +6 authors, Dingbo Lin.
J Nutr Food Sci, 2012 Jun 12; S2. PMID: 22685690    Free PMC article.
Molecular pathways in pancreatic carcinogenesis.
Anne M Macgregor-Das, Christine A Iacobuzio-Donahue.
J Surg Oncol, 2012 Jul 19; 107(1). PMID: 22806689    Free PMC article.
Review.
Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer.
Yan Jia, Yunsheng Yang, +3 authors, Mingzhou Guo.
J Pathol, 2012 Jul 19; 230(2). PMID: 22806826    Free PMC article.
Insulin detemir enhances proglucagon gene expression in the intestinal L cells via stimulating β-catenin and CREB activities.
Shenghao Liu, Rui Liu, +4 authors, Qinghua Wang.
Am J Physiol Endocrinol Metab, 2012 Jul 20; 303(6). PMID: 22811470    Free PMC article.
Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway.
N Skalka, M Caspi, +2 authors, R Rosin-Arbesfeld.
Oncogene, 2012 Jul 25; 32(23). PMID: 22824791    Free PMC article.
Inhibitory effects of lupeal acetate of Cortex periplocae on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis.
Lifang Wang, An Lu, +2 authors, Baoen Shan.
Oncol Lett, 2012 Jul 31; 4(2). PMID: 22844359    Free PMC article.
γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin.
R G Morgan, L Pearn, +4 authors, R L Darley.
Leukemia, 2012 Aug 04; 27(2). PMID: 22858986    Free PMC article.
Signaling in colon cancer stem cells.
Sanchita Roy, Adhip Pn Majumdar.
J Mol Signal, 2012 Aug 08; 7(1). PMID: 22866952    Free PMC article.
Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of β-catenin.
Amy K Rines, Michael A Burke, +2 authors, Hossein Ardehali.
FASEB J, 2012 Aug 10; 26(11). PMID: 22874833    Free PMC article.
Copy number variation of the APC gene is associated with regulation of bone mineral density.
Shelby Chew, Zari Dastani, +7 authors, Scott G Wilson.
Bone, 2012 Aug 14; 51(5). PMID: 22884971    Free PMC article.
The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective.
Wilfred Ip, Yu-Ting Alex Chiang, Tianru Jin.
Cell Biosci, 2012 Aug 16; 2(1). PMID: 22892353    Free PMC article.
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation.
Helena Shaked, Lorne J Hofseth, +9 authors, Michael Karin.
Proc Natl Acad Sci U S A, 2012 Aug 16; 109(35). PMID: 22893683    Free PMC article.
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.
Chen Wu, Peter Kraft, +33 authors, Dongxin Lin.
Nat Genet, 2012 Sep 11; 44(10). PMID: 22960999
Highly Cited.
The Wnt/β-catenin/T-cell factor 4 pathway up-regulates high-mobility group A1 expression in colon cancer.
Bethany M Bush, Ashton T Brock, +2 authors, Takita Felder Sumter.
Cell Biochem Funct, 2012 Sep 11; 31(3). PMID: 22961697    Free PMC article.
MiR-214 targets β-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma.
Hongping Xia, London Lucien P J Ooi, Kam M Hui.
PLoS One, 2012 Sep 11; 7(9). PMID: 22962603    Free PMC article.
Highly Cited.
The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis.
Wilfred Ip, Weijuan Shao, Yu-ting Alex Chiang, Tianru Jin.
Am J Physiol Endocrinol Metab, 2012 Sep 13; 303(9). PMID: 22967502    Free PMC article.
Tyrosine phosphatase PTPRD suppresses colon cancer cell migration in coordination with CD44.
Kosuke Funato, Yusuke Yamazumi, Takeaki Oda, Tetsu Akiyama.
Exp Ther Med, 2011 May 01; 2(3). PMID: 22977525    Free PMC article.
Wnt pathway activation predicts increased risk of tumor recurrence in patients with stage I nonsmall cell lung cancer.
Mark Shapiro, Gal Akiri, +5 authors, Stuart A Aaronson.
Ann Surg, 2012 Sep 27; 257(3). PMID: 23011390    Free PMC article.
Nuclear accumulation of β-catenin and forkhead box O3a in colon cancer: Dangerous liaison.
Wolfgang Link.
World J Biol Chem, 2012 Oct 02; 3(9). PMID: 23024836    Free PMC article.
Activating mutations in β-catenin in colon cancer cells alter their interaction with macrophages; the role of snail.
Pawan Kaler, Leonard Augenlicht, Lidija Klampfer.
PLoS One, 2012 Oct 03; 7(9). PMID: 23029025    Free PMC article.
Inhibition of Tcf-4 induces apoptosis and enhances chemosensitivity of colon cancer cells.
Jiang Xie, De-Bing Xiang, +5 authors, Xiao-Lei Wang.
PLoS One, 2012 Oct 03; 7(9). PMID: 23029137    Free PMC article.
Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts.
Rongrong Zhang, Babatunde O Oyajobi, +4 authors, Ming Zhao.
Bone, 2012 Oct 04; 52(1). PMID: 23032104    Free PMC article.
Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch.
Fred E Bertrand, C William Angus, William J Partis, George Sigounas.
Cell Cycle, 2012 Oct 04; 11(23). PMID: 23032367    Free PMC article.
Review.
Identifying novel protein complexes in cancer cells using epitope-tagging of endogenous human genes and affinity-purification mass spectrometry.
Jing Song, Yujun Hao, +2 authors, Rob M Ewing.
J Proteome Res, 2012 Oct 31; 11(12). PMID: 23106643    Free PMC article.
A De Novo Germline APC Mutation (3927del5) in a Patient with Familial Adenomatous Polyposis: Case Report and Literature Review.
Simon B Zeichner, Naveen Raj, +2 authors, Alicia Hirzel.
Clin Med Insights Oncol, 2012 Nov 02; 6. PMID: 23115482    Free PMC article.
Galectin-1 and Galectin-3 Mediate Protocadherin-24-Dependent Membrane Localization of β-catenin in Colon Cancer Cell Line HCT116.
Rui Ose, Osamu Oharaa, Takahiro Nagase.
Curr Chem Genomics, 2012 Nov 02; 6. PMID: 23115611    Free PMC article.
Structure and activity analysis of Inauhzin analogs as novel antitumor compounds that induce p53 and inhibit cell growth.
Qi Zhang, Derong Ding, +2 authors, Hua Lu.
PLoS One, 2012 Nov 02; 7(10). PMID: 23115626    Free PMC article.
Primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma: a persisting diagnostic challenge.
Somak Roy, Matthew A Smith, +2 authors, Anil V Parwani.
Diagn Pathol, 2012 Nov 06; 7. PMID: 23121893    Free PMC article.
Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.
Renyue Bao, Tania Christova, +3 authors, Liliana Attisano.
PLoS One, 2012 Nov 13; 7(11). PMID: 23144924    Free PMC article.
Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1.
Vineeta Khare, Alex Lyakhovich, +10 authors, Christoph Gasche.
Biochem Pharmacol, 2012 Nov 14; 85(2). PMID: 23146664    Free PMC article.
Inflammation and colorectal cancer: colitis-associated neoplasia.
Sergei I Grivennikov.
Semin Immunopathol, 2012 Nov 20; 35(2). PMID: 23161445    Free PMC article.
Highly Cited. Review.
The β-catenin destruction complex.
Jennifer L Stamos, William I Weis.
Cold Spring Harb Perspect Biol, 2012 Nov 22; 5(1). PMID: 23169527    Free PMC article.
Highly Cited. Review.
Tankyrase-targeted therapeutics: expanding opportunities in the PARP family.
Jenna L Riffell, Christopher J Lord, Alan Ashworth.
Nat Rev Drug Discov, 2012 Dec 01; 11(12). PMID: 23197039
Highly Cited. Review.
Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium.
Akihiro Hirata, Jochen Utikal, +11 authors, Yasuhiro Yamada.
Development, 2012 Dec 12; 140(1). PMID: 23222438    Free PMC article.
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis.
Joseph Rosenbluh, Deepak Nijhawan, +18 authors, William C Hahn.
Cell, 2012 Dec 19; 151(7). PMID: 23245941    Free PMC article.
Highly Cited.
Molecular pathways undergoing dramatic transcriptomic changes during tumor development in the human colon.
Rosalia Maglietta, Vania Cosma Liuzzi, +10 authors, Nicola Ancona.
BMC Cancer, 2012 Dec 21; 12. PMID: 23253212    Free PMC article.
Analysis of APC and IGFBP7 promoter gene methylation in Swedish and Vietnamese colorectal cancer patients.
Jan Dimberg, Thai Trinh Hong, +3 authors, Andreas Matussek.
Oncol Lett, 2012 Dec 21; 5(1). PMID: 23255887    Free PMC article.
The way Wnt works: components and mechanism.
Kenyi Saito-Diaz, Tony W Chen, +4 authors, Ethan Lee.
Growth Factors, 2012 Dec 22; 31(1). PMID: 23256519    Free PMC article.
Highly Cited. Review.
WNT signalling pathways as therapeutic targets in cancer.
Jamie N Anastas, Randall T Moon.
Nat Rev Cancer, 2012 Dec 22; 13(1). PMID: 23258168
Highly Cited. Review.
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
Ulrike Peters, Shuo Jiao, +74 authors, Colon Cancer Family Registry and the Genetics and Epidemiology of Colorectal Cancer Consortium.
Gastroenterology, 2012 Dec 26; 144(4). PMID: 23266556    Free PMC article.
Highly Cited. Review.
Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis.
Upal K Basu Roy, Rebecca S Henkhaus, +3 authors, Natalia A Ignatenko.
Int J Cancer, 2013 Jan 03; 133(1). PMID: 23280667    Free PMC article.
AMPK activators suppress cervical cancer cell growth through inhibition of DVL3 mediated Wnt/β-catenin signaling activity.
H T Kwan, David W Chan, +6 authors, Hextan Y S Ngan.
PLoS One, 2013 Jan 10; 8(1). PMID: 23301094    Free PMC article.
Multicolor lineage tracing methods and intestinal tumors.
Hirotsugu Yanai, Toshihiro Tanaka, Hiroo Ueno.
J Gastroenterol, 2013 Jan 12; 48(4). PMID: 23307044    Free PMC article.
Review.
Tracing the cellular origin of cancer.
Cédric Blanpain.
Nat Cell Biol, 2013 Jan 22; 15(2). PMID: 23334500
Highly Cited. Review.
Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers.
Jüri Reimand, Gary D Bader.
Mol Syst Biol, 2013 Jan 24; 9. PMID: 23340843    Free PMC article.
Highly Cited.
Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.
Luc G T Morris, Andrew M Kaufman, +19 authors, Timothy A Chan.
Nat Genet, 2013 Jan 29; 45(3). PMID: 23354438    Free PMC article.
Highly Cited.
Loss of WIF-1 and Wnt5a expression is related to aggressiveness of sporadic breast cancer in Tunisian patients.
Fatma Trifa, Sondes Karray-Chouayekh, +6 authors, Raja Mokdad-Gargouri.
Tumour Biol, 2013 Feb 19; 34(3). PMID: 23417837
Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice.
Kei Semba, Kimi Araki, +15 authors, Ken-ichi Yamamura.
PLoS Genet, 2013 Feb 26; 9(2). PMID: 23436999    Free PMC article.
Pharmacological modulation of beta-catenin and its applications in cancer therapy.
Ravi Thakur, Durga Prasad Mishra.
J Cell Mol Med, 2013 Mar 16; 17(4). PMID: 23490077    Free PMC article.
Review.
CTNNB1, AXIN1 and APC expression analysis of different medulloblastoma variants.
Roseli da Silva, Suely K N Marie, +4 authors, Sueli M Oba-Shinjo.
Clinics (Sao Paulo), 2013 Mar 26; 68(2). PMID: 23525311    Free PMC article.
Cancer genome landscapes.
Bert Vogelstein, Nickolas Papadopoulos, +3 authors, Kenneth W Kinzler.
Science, 2013 Mar 30; 339(6127). PMID: 23539594    Free PMC article.
Highly Cited. Review.
Down-regulation of miR-21 Induces Differentiation of Chemoresistant Colon Cancer Cells and Enhances Susceptibility to Therapeutic Regimens.
Yingjie Yu, Fazlul H Sarkar, Adhip P N Majumdar.
Transl Oncol, 2013 Apr 02; 6(2). PMID: 23544170    Free PMC article.
PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-catenin.
J Lee, C Bartholomeusz, +5 authors, N T Ueno.
Oncogenesis, 2012 Jan 01; 1. PMID: 23552738    Free PMC article.
Heavy ion radiation exposure triggered higher intestinal tumor frequency and greater β-catenin activation than γ radiation in APC(Min/+) mice.
Kamal Datta, Shubhankar Suman, Bhaskar V S Kallakury, Albert J Fornace.
PLoS One, 2013 Apr 05; 8(3). PMID: 23555653    Free PMC article.
Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling.
Changgong Li, Aimin Li, +7 authors, Parviz Minoo.
Dev Biol, 2013 Apr 09; 378(1). PMID: 23562608    Free PMC article.
SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis.
Yu Fu, Binlu Huang, +4 authors, Wei Wu.
EMBO Mol Med, 2013 Apr 18; 5(5). PMID: 23592547    Free PMC article.
Malignant pilomatricoma with multiple bone metastases in a dog: Histological and immunohistochemical study.
Manuela Martano, Luigi Navas, +4 authors, Lorenzo Lo Muzio.
Exp Ther Med, 2013 Apr 19; 5(4). PMID: 23596465    Free PMC article.
ADAR1 is essential for intestinal homeostasis and stem cell maintenance.
W Qiu, X Wang, +5 authors, J Yu.
Cell Death Dis, 2013 Apr 20; 4. PMID: 23598411    Free PMC article.
Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells.
Alessandra De Robertis, Silvia Valensin, +20 authors, Massimiliano Salerno.
Mol Cancer Ther, 2013 Apr 27; 12(7). PMID: 23619303    Free PMC article.
Evidence for tankyrases as antineoplastic targets in lung cancer.
Alexander M Busch, Kevin C Johnson, +4 authors, Sarah J Freemantle.
BMC Cancer, 2013 Apr 30; 13. PMID: 23621985    Free PMC article.
p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells.
Nam Hee Kim, Yong Hoon Cha, +10 authors, Hyun Sil Kim.
Cell Cycle, 2013 Apr 30; 12(10). PMID: 23624843    Free PMC article.
Tissue transglutaminase regulates β-catenin signaling through a c-Src-dependent mechanism.
Salvatore Condello, Liyun Cao, Daniela Matei.
FASEB J, 2013 May 04; 27(8). PMID: 23640056    Free PMC article.
ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.
Kevin B Myant, Patrizia Cammareri, +13 authors, Owen J Sansom.
Cell Stem Cell, 2013 May 15; 12(6). PMID: 23665120    Free PMC article.
Highly Cited.
Prognostic Significance of BCL9 Expression in Hepatocellular Carcinoma.
Jiyeon Hyeon, Soomin Ahn, +2 authors, Cheol-Keun Park.
Korean J Pathol, 2013 May 15; 47(2). PMID: 23667372    Free PMC article.
A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis.
Ling Shao, Shigeru Oshima, +4 authors, Averil Ma.
PLoS One, 2013 May 15; 8(5). PMID: 23671587    Free PMC article.
TLR4 activates the β-catenin pathway to cause intestinal neoplasia.
Rebeca Santaolalla, Daniel A Sussman, +15 authors, Maria T Abreu.
PLoS One, 2013 May 22; 8(5). PMID: 23691015    Free PMC article.
Stem cell signaling as a target for novel drug discovery: recent progress in the WNT and Hedgehog pathways.
Songzhu Michael An, Qiang Peter Ding, Ling-song Li.
Acta Pharmacol Sin, 2013 May 28; 34(6). PMID: 23708555    Free PMC article.
Review.
In vitro organoid culture of primary mouse colon tumors.
Xiang Xue, Yatrik M Shah.
J Vis Exp, 2013 May 29; (75). PMID: 23711911    Free PMC article.
Enhanced CRAd activity using enhancer motifs driven by a nucleosome positioning sequence.
Soraya Bravo, Felipe Núñez, +4 authors, Osvaldo L Podhajcer.
Mol Ther, 2013 May 29; 21(7). PMID: 23712038    Free PMC article.
ToP: a trend-of-disease-progression procedure works well for identifying cancer genes from multi-state cohort gene expression data for human colorectal cancer.
Feng-Hsiang Chung, Henry Hsin-Chung Lee, Hoong-Chien Lee.
PLoS One, 2013 Jun 27; 8(6). PMID: 23799036    Free PMC article.
β-catenin at the centrosome: discrete pools of β-catenin communicate during mitosis and may co-ordinate centrosome functions and cell cycle progression.
Bertrade C Mbom, W James Nelson, Angela Barth.
Bioessays, 2013 Jun 28; 35(9). PMID: 23804296    Free PMC article.
Review.
Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.
Nan Li, Yaguang Xi, +12 authors, Gary A Piazza.
Mol Cancer Ther, 2013 Jun 28; 12(9). PMID: 23804703    Free PMC article.
Requirement for active glycogen synthase kinase-3β in TGF-β1 upregulation of connective tissue growth factor (CCN2/CTGF) levels in human gingival fibroblasts.
Maha Bahammam, Samuel A Black, +3 authors, Philip C Trackman.
Am J Physiol Cell Physiol, 2013 Jul 05; 305(6). PMID: 23824844    Free PMC article.
The dietary terpene lupeol targets colorectal cancer cells with constitutively active Wnt/β-catenin signaling.
Rohinton S Tarapore, Imtiaz A Siddiqui, +2 authors, Hasan Mukhtar.
Mol Nutr Food Res, 2013 Jul 10; 57(11). PMID: 23836602    Free PMC article.
GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos.
Angela M Sousa Costa, Isabel Pereira-Castro, +3 authors, Luís Teixeira da Costa.
PLoS One, 2013 Jul 11; 8(7). PMID: 23840876    Free PMC article.
The non-canonical Wnt/PKC pathway regulates mitochondrial dynamics through degradation of the arm-like domain-containing protein Alex3.
Román Serrat, Guillermo López-Doménech, +5 authors, Eduardo Soriano.
PLoS One, 2013 Jul 12; 8(7). PMID: 23844091    Free PMC article.
Henryin, an ent-kaurane diterpenoid, inhibits Wnt signaling through interference with β-catenin/TCF4 interaction in colorectal cancer cells.
Xingyao Li, Jianxin Pu, +5 authors, Yan Li.
PLoS One, 2013 Jul 12; 8(7). PMID: 23844215    Free PMC article.
CBP Activity Mediates Effects of the Histone Deacetylase Inhibitor Butyrate on WNT Activity and Apoptosis in Colon Cancer Cells.
Darina L Lazarova, Christopher Chiaro, +4 authors, Michael Bordonaro.
J Cancer, 2013 Aug 01; 4(6). PMID: 23901348    Free PMC article.
p300 Influences Butyrate-Mediated WNT Hyperactivation In Colorectal Cancer Cells.
Darina L Lazarova, Terrence Wong, +2 authors, Michael Bordonaro.
J Cancer, 2013 Aug 01; 4(6). PMID: 23901349    Free PMC article.
Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin.
Mara Roxana Rubinstein, Xiaowei Wang, +3 authors, Yiping W Han.
Cell Host Microbe, 2013 Aug 21; 14(2). PMID: 23954158    Free PMC article.
Highly Cited.
Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention.
Dora Colussi, Giovanni Brandi, Franco Bazzoli, Luigi Ricciardiello.
Int J Mol Sci, 2013 Aug 24; 14(8). PMID: 23965959    Free PMC article.
Highly Cited. Review.
Immunohistochemical analysis of retinoblastoma and β-catenin as an assistant tool in the differential diagnosis between Crohn's disease and ulcerative colitis.
Rossana Colla Soletti, Nathassya Accioly Lins Vidal Rodrigues, +3 authors, Helena Lobo Borges.
PLoS One, 2013 Aug 24; 8(8). PMID: 23967107    Free PMC article.
Procalcitonin beyond the acute phase: novel biomediator properties?
Carolina Panico, Eric Nylen.
BMC Med, 2013 Aug 30; 11. PMID: 23984981    Free PMC article.
Nitric oxide production upregulates Wnt/β-catenin signaling by inhibiting Dickkopf-1.
Qiang Du, Xinglu Zhang, +3 authors, David A Geller.
Cancer Res, 2013 Sep 07; 73(21). PMID: 24008318    Free PMC article.
Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen.
Jijun Hao, Ada Ao, +7 authors, Charles C Hong.
Cell Rep, 2013 Sep 10; 4(5). PMID: 24012757    Free PMC article.
Aflatoxin B1 negatively regulates Wnt/β-catenin signaling pathway through activating miR-33a.
Yi Fang, Youjun Feng, +5 authors, Shihua Wang.
PLoS One, 2013 Sep 10; 8(8). PMID: 24015284    Free PMC article.
The Roles of SIRT1 in Cancer.
Zhenghong Lin, Deyu Fang.
Genes Cancer, 2013 Sep 11; 4(3-4). PMID: 24020000    Free PMC article.
Genetic and epigenetic changes in sporadic endocrine tumors: parathyroid tumors.
Jessica Costa-Guda, Andrew Arnold.
Mol Cell Endocrinol, 2013 Sep 17; 386(1-2). PMID: 24035866    Free PMC article.
Review.
Wingless/Wnt signaling in Drosophila: the pattern and the pathway.
Amy Bejsovec.
Mol Reprod Dev, 2013 Sep 17; 80(11). PMID: 24038436    Free PMC article.
Review.
Epithelial-mesenchymal transition associates with maintenance of stemness in spheroid-derived stem-like colon cancer cells.
Xiao-Yan Han, Bo Wei, +6 authors, Hong-Bo Wei.
PLoS One, 2013 Sep 17; 8(9). PMID: 24039918    Free PMC article.
The Wnt/β-catenin pathway regulates the expression of the miR-302 cluster in mouse ESCs and P19 cells.
Christien Bräutigam, Angelo Raggioli, Jennifer Winter.
PLoS One, 2013 Sep 17; 8(9). PMID: 24040406    Free PMC article.
Unravelling cancer stem cell potential.
Benjamin Beck, Cédric Blanpain.
Nat Rev Cancer, 2013 Sep 26; 13(10). PMID: 24060864
Highly Cited. Review.
The mutational landscape of phosphorylation signaling in cancer.
Jüri Reimand, Omar Wagih, Gary D Bader.
Sci Rep, 2013 Oct 04; 3. PMID: 24089029    Free PMC article.
Highly Cited.
Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish.
Alexander J Valvezan, Jian Huang, +2 authors, Peter S Klein.
Dis Model Mech, 2013 Oct 05; 7(1). PMID: 24092877    Free PMC article.
Impaired DICER1 function promotes stemness and metastasis in colon cancer.
M S Iliou, V da Silva-Diz, +5 authors, M Esteller.
Oncogene, 2013 Oct 08; 33(30). PMID: 24096488    Free PMC article.
Esculetin suppresses proliferation of human colon cancer cells by directly targeting β-catenin.
Sung-Young Lee, Tae-Gyu Lim, +9 authors, Zigang Dong.
Cancer Prev Res (Phila), 2013 Oct 10; 6(12). PMID: 24104353    Free PMC article.
Toggling a conformational switch in Wnt/β-catenin signaling: regulation of Axin phosphorylation. The phosphorylation state of Axin controls its scaffold function in two Wnt pathway protein complexes.
Ofelia Tacchelly-Benites, Zhenghan Wang, +2 authors, Yashi Ahmed.
Bioessays, 2013 Oct 10; 35(12). PMID: 24105937    Free PMC article.
Review.
The Cdc42/Rac nucleotide exchange factor protein β1Pix (Pak-interacting exchange factor) modulates β-catenin transcriptional activity in colon cancer cells: evidence for direct interaction of β1PIX with β-catenin.
Ahmed Chahdi, Jean-Pierre Raufman.
J Biol Chem, 2013 Oct 17; 288(47). PMID: 24129564    Free PMC article.
Epigenetic regulation of DACH1, a novel Wnt signaling component in colorectal cancer.
Wenji Yan, Kongming Wu, +7 authors, Mingzhou Guo.
Epigenetics, 2013 Oct 24; 8(12). PMID: 24149323    Free PMC article.
Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells.
Oksana Voloshanenko, Gerrit Erdmann, +14 authors, Michael Boutros.
Nat Commun, 2013 Oct 29; 4. PMID: 24162018    Free PMC article.
Highly Cited.
Mutator/Hypermutable fetal/juvenile metakaryotic stem cells and human colorectal carcinogenesis.
Lohith G Kini, Pablo Herrero-Jimenez, +12 authors, William G Thilly.
Front Oncol, 2013 Nov 07; 3. PMID: 24195059    Free PMC article.
Review.
[In situ analyses of molecular mechanisms of colorectal carcinogenesis].
L Kriegl.
Pathologe, 2013 Nov 15; 34 Suppl 2. PMID: 24196627
Review.
Integrated analysis of the Wnt responsive proteome in human cells reveals diverse and cell-type specific networks.
J Song, Z Wang, R M Ewing.
Mol Biosyst, 2013 Nov 10; 10(1). PMID: 24201312    Free PMC article.
Colon cryptogenesis: asymmetric budding.
Chin Wee Tan, Yumiko Hirokawa, +2 authors, Antony W Burgess.
PLoS One, 2013 Nov 10; 8(10). PMID: 24205248    Free PMC article.
Regulatory T cells in colorectal cancer: from biology to prognostic relevance.
Dimitrios Mougiakakos.
Cancers (Basel), 2011 Jan 01; 3(2). PMID: 24212779    Free PMC article.
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.
Grace Chappell, Kristy Kutanzi, +6 authors, Igor P Pogribny.
Int J Cancer, 2013 Nov 19; 134(12). PMID: 24242335    Free PMC article.
Preventive inositol hexaphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/β-catenin and COX-2 pathways.
Nurul Husna Shafie, Norhaizan Mohd Esa, +3 authors, Ashok Kumar Pandurangan.
Biomed Res Int, 2013 Nov 22; 2013. PMID: 24260743    Free PMC article.
NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling.
Jarred P Tanksley, Xi Chen, Robert J Coffey.
PLoS One, 2013 Dec 07; 8(11). PMID: 24312311    Free PMC article.
Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells.
Zongwei Li, Lichao Zhang, +2 authors, Zhuoyu Li.
BMB Rep, 2013 Dec 10; 47(8). PMID: 24314144    Free PMC article.
Modulation of β-catenin signaling by the inhibitors of MAP kinase, tyrosine kinase, and PI3-kinase pathways.
Wenwen Zhang, Hongyu Zhang, +17 authors, Tong-Chuan He.
Int J Med Sci, 2013 Dec 11; 10(13). PMID: 24324366    Free PMC article.
Destabilization of heterologous proteins mediated by the GSK3β phosphorylation domain of the β-catenin protein.
Yuhan Kong, Hongyu Zhang, +17 authors, Lan Zhou.
Cell Physiol Biochem, 2013 Dec 18; 32(5). PMID: 24335169    Free PMC article.
Citrobacter Infection and Wnt signaling.
Shahid Umar.
Curr Colorectal Cancer Rep, 2013 Dec 21; 8(4). PMID: 24358033    Free PMC article.
Vitamin D, Vitamin D Receptor, and Tissue Barriers.
Yong-Guo Zhang, Shaoping Wu, Jun Sun.
Tissue Barriers, 2013 Dec 21; 1(1). PMID: 24358453    Free PMC article.
LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction.
Jiong Li, Xiaohong Chen, +7 authors, Cun-Yu Wang.
Cell Rep, 2013 Dec 24; 5(6). PMID: 24360964    Free PMC article.
A colon cancer-derived mutant of Krüppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3β (GSK3β) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7α (FBW7α).
Agnieszka B Bialkowska, Yang Liu, Mandayam O Nandan, Vincent W Yang.
J Biol Chem, 2014 Jan 09; 289(9). PMID: 24398687    Free PMC article.
LRP5 knockdown: effect on prostate cancer invasion growth and skeletal metastasis in vitro and in vivo.
Shafaat A Rabbani, Ani Arakelian, Riaz Farookhi.
Cancer Med, 2014 Jan 10; 2(5). PMID: 24403228    Free PMC article.
Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF.
Jurian Schuijers, Michal Mokry, +2 authors, Hans Clevers.
EMBO J, 2014 Jan 15; 33(2). PMID: 24413017    Free PMC article.
Highly Cited.
KIF3a promotes proliferation and invasion via Wnt signaling in advanced prostate cancer.
Zun Liu, Ryan E Rebowe, +6 authors, Wanguo Liu.
Mol Cancer Res, 2014 Jan 15; 12(4). PMID: 24413182    Free PMC article.
Hypoxia triggers a Nur77-β-catenin feed-forward loop to promote the invasive growth of colon cancer cells.
S K Y To, W-J Zeng, J-Z Zeng, A S T Wong.
Br J Cancer, 2014 Jan 16; 110(4). PMID: 24423919    Free PMC article.
Metformin: a potential therapeutic agent for recurrent colon cancer.
Pratima Nangia-Makker, Yingjie Yu, +4 authors, Adhip P N Majumdar.
PLoS One, 2014 Jan 28; 9(1). PMID: 24465408    Free PMC article.
Nek2 phosphorylates and stabilizes β-catenin at mitotic centrosomes downstream of Plk1.
Bertrade C Mbom, Kathleen A Siemers, +2 authors, Angela I M Barth.
Mol Biol Cell, 2014 Feb 07; 25(7). PMID: 24501426    Free PMC article.
Conserved mechanisms of tumorigenesis in the Drosophila adult midgut.
Òscar Martorell, Anna Merlos-Suárez, +6 authors, Andreu Casali.
PLoS One, 2014 Feb 12; 9(2). PMID: 24516653    Free PMC article.
Atrial natriuretic peptide: a magic bullet for cancer therapy targeting Wnt signaling and cellular pH regulators.
A Serafino, P Pierimarchi.
Curr Med Chem, 2014 Feb 15; 21(21). PMID: 24524761    Free PMC article.
Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo.
Adrianna K San Roman, Chenura D Jayewickreme, L Charles Murtaugh, Ramesh A Shivdasani.
Stem Cell Reports, 2014 Feb 15; 2(2). PMID: 24527386    Free PMC article.
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.
Wim de Lau, Weng Chuan Peng, Piet Gros, Hans Clevers.
Genes Dev, 2014 Feb 18; 28(4). PMID: 24532711    Free PMC article.
Highly Cited. Review.
Activated macrophages promote Wnt/β-catenin signaling in cholangiocarcinoma cells.
Watcharin Loilome, Pornpan Bungkanjana, +5 authors, Gregory J Riggins.
Tumour Biol, 2014 Feb 20; 35(6). PMID: 24549785    Free PMC article.
Modulation of Wnt Activity and Cell Physiology by Butyrate in LT97 Microadenoma Cells.
Darina Lazarova, Andrew Lee, +4 authors, Michael Bordonaro.
J Cancer, 2014 Feb 25; 5(3). PMID: 24563675    Free PMC article.
Wnt modulates MCL1 to control cell survival in triple negative breast cancer.
Lixin Yang, Aldwin Apollo Perez, +11 authors, Yun Yen.
BMC Cancer, 2014 Feb 26; 14. PMID: 24564888    Free PMC article.
Genetic unraveling of colorectal cancer.
Sabha Rasool, Vamiq Rasool, +2 authors, Bhahwal Ali Shah.
Tumour Biol, 2014 Feb 28; 35(6). PMID: 24573608
Review.
Approaches that ascertain the role of dietary compounds in colonic cancer cells.
Michael Bordonaro, Koen Venema, Adeline K Putri, Darina Lazarova.
World J Gastrointest Oncol, 2014 Mar 01; 6(1). PMID: 24578783    Free PMC article.
Review.
5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis.
Kenneth K Wu, Huei-Hsuan Cheng, Tzu-Ching Chang.
J Biomed Sci, 2014 Mar 05; 21. PMID: 24589238    Free PMC article.
Review.
Wnt-independent role of β-catenin in thyroid cell proliferation and differentiation.
Ana Sastre-Perona, Pilar Santisteban.
Mol Endocrinol, 2014 Mar 22; 28(5). PMID: 24645679    Free PMC article.
Regulation of stem cell function by protein ubiquitylation.
Alexandros Strikoudis, Maria Guillamot, Iannis Aifantis.
EMBO Rep, 2014 Mar 22; 15(4). PMID: 24652853    Free PMC article.
Review.
WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer.
Annalucia Serafino, Noemi Moroni, +8 authors, Pasquale Pierimarchi.
Oncotarget, 2014 Mar 25; 5(4). PMID: 24657851    Free PMC article.
Structure and function of LGR5: an enigmatic G-protein coupled receptor marking stem cells.
Kaavya Krishna Kumar, Antony W Burgess, Jacqueline M Gulbis.
Protein Sci, 2014 Mar 29; 23(5). PMID: 24677446    Free PMC article.
Review.
CTNNB1 mutational analysis of solid-pseudopapillary neoplasms of the pancreas using endoscopic ultrasound-guided fine-needle aspiration and next-generation deep sequencing.
Yoshimasa Kubota, Hiroshi Kawakami, +10 authors, Naoya Sakamoto.
J Gastroenterol, 2014 Apr 05; 50(2). PMID: 24700283
Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.
N Li, K Lee, +21 authors, G A Piazza.
Oncogene, 2014 Apr 08; 34(12). PMID: 24704829    Free PMC article.
Butyrate induced changes in Wnt-signaling specific gene expression in colorectal cancer cells.
Darina L Lazarova, Christopher Chiaro, Michael Bordonaro.
BMC Res Notes, 2014 Apr 11; 7. PMID: 24716727    Free PMC article.
14-3-3 and β-catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway.
Shiri Dovrat, Michal Caspi, +4 authors, Rina Rosin-Arbesfeld.
Mol Oncol, 2014 Apr 12; 8(5). PMID: 24721736    Free PMC article.
KCTD1 suppresses canonical Wnt signaling pathway by enhancing β-catenin degradation.
Xinxin Li, Cheng Chen, +9 authors, Jian Zhang.
PLoS One, 2014 Apr 17; 9(4). PMID: 24736394    Free PMC article.
O-GlcNAcylation stabilizes β-catenin through direct competition with phosphorylation at threonine 41.
Stéphanie Olivier-Van Stichelen, Vanessa Dehennaut, +9 authors, Tony Lefebvre.
FASEB J, 2014 Apr 20; 28(8). PMID: 24744147    Free PMC article.
Targeting mTOR network in colorectal cancer therapy.
Xiao-Wen Wang, Yan-Jie Zhang.
World J Gastroenterol, 2014 Apr 26; 20(15). PMID: 24764656    Free PMC article.
Review.
Downregulation of WIF-1 and Wnt5a in patients with colorectal carcinoma: clinical significance.
Rania Abdelmaksoud-Dammak, Imen Miladi-Abdennadher, +5 authors, Raja Mokdad-Gargouri.
Tumour Biol, 2014 May 17; 35(8). PMID: 24833087
Melanoma Development and Progression Are Associated with Rad6 Upregulation and β -Catenin Relocation to the Cell Membrane.
Karli Rosner, Darius R Mehregan, +7 authors, Malathy P V Shekhar.
J Skin Cancer, 2014 Jun 04; 2014. PMID: 24891954    Free PMC article.
The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis.
Uwe Knippschild, Marc Krüger, +6 authors, Joachim Bischof.
Front Oncol, 2014 Jun 07; 4. PMID: 24904820    Free PMC article.
Highly Cited. Review.
Prognostic Significance of β-Catenin, E-Cadherin, and SOX9 in Colorectal Cancer: Results from a Large Population-Representative Series.
Jarle Bruun, Matthias Kolberg, +3 authors, Ragnhild A Lothe.
Front Oncol, 2014 Jun 07; 4. PMID: 24904831    Free PMC article.
A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12.
Arnaud Duquet, Alice Melotti, +4 authors, Ariel Ruiz i Altaba.
EMBO Mol Med, 2014 Jun 13; 6(7). PMID: 24920608    Free PMC article.
Defining hierarchies of stemness in the intestine: evidence from biomarkers and regulatory pathways.
A D Gracz, S T Magness.
Am J Physiol Gastrointest Liver Physiol, 2014 Jun 14; 307(3). PMID: 24924746    Free PMC article.
Review.
Distinct WNT/β-catenin signaling activation in the serrated neoplasia pathway and the adenoma-carcinoma sequence of the colorectum.
Takashi Murakami, Hiroyuki Mitomi, +5 authors, Sumio Watanabe.
Mod Pathol, 2014 Jun 14; 28(1). PMID: 24925057
MicroRNA profiling in Muc2 knockout mice of colitis-associated cancer model reveals epigenetic alterations during chronic colitis malignant transformation.
Yonghua Bao, Yongchen Guo, +10 authors, Wancai Yang.
PLoS One, 2014 Jun 19; 9(6). PMID: 24941171    Free PMC article.
Coexpression of SFRP1 and WIF1 as a prognostic predictor of favorable outcomes in patients with colorectal carcinoma.
Shiyong Huang, XiaoMing Zhong, +8 authors, Zikang Li.
Biomed Res Int, 2014 Jun 21; 2014. PMID: 24949429    Free PMC article.
Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer.
Jun Yu, William K K Wu, +23 authors, Joseph J Y Sung.
Gut, 2014 Jun 22; 64(4). PMID: 24951259    Free PMC article.
Highly Cited.
Two Natural ent-kauranoids as Novel Wnt Signaling Inhibitors.
Jing Zhang, Ling-Mei Kong, +4 authors, Yan Li.
Nat Prod Bioprospect, 2014 Jun 24; 4(3). PMID: 24955294    Free PMC article.
Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells.
Nhi Huynh, Kevin H Liu, +3 authors, Hong He.
Physiol Rep, 2014 Jun 26; 2(6). PMID: 24963032    Free PMC article.
Tankyrases: structure, function and therapeutic implications in cancer.
Teemu Haikarainen, Stefan Krauss, Lari Lehtio.
Curr Pharm Des, 2014 Jul 01; 20(41). PMID: 24975604    Free PMC article.
Review.
Molecular docking studies of flavonoids for their inhibition pattern against β-catenin and pharmacophore model generation from experimentally known flavonoids to fabricate more potent inhibitors for Wnt signaling pathway.
Hira Iftikhar, Sajid Rashid.
Pharmacogn Mag, 2014 Jul 06; 10(Suppl 2). PMID: 24991101    Free PMC article.
Aldolase positively regulates of the canonical Wnt signaling pathway.
Michal Caspi, Gili Perry, +4 authors, Rina Rosin-Arbesfeld.
Mol Cancer, 2014 Jul 06; 13. PMID: 24993527    Free PMC article.
LZTFL1 suppresses gastric cancer cell migration and invasion through regulating nuclear translocation of β-catenin.
Linbo Wang, Jufeng Guo, +6 authors, Zhi-Ping Liu.
J Cancer Res Clin Oncol, 2014 Jul 10; 140(12). PMID: 25005785
Intranodal palisaded myofibroblastoma: another mesenchymal neoplasm with CTNNB1 (β-catenin gene) mutations: clinicopathologic, immunohistochemical, and molecular genetic study of 18 cases.
William B Laskin, Jerzy P Lasota, +3 authors, Markku Miettinen.
Am J Surg Pathol, 2014 Jul 16; 39(2). PMID: 25025452    Free PMC article.
Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms.
Elisabeth M Walczak, Rork Kuick, +4 authors, Gary D Hammer.
Mol Endocrinol, 2014 Jul 17; 28(9). PMID: 25029241    Free PMC article.
Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling.
Wen-Hui Lien, Elaine Fuchs.
Genes Dev, 2014 Jul 18; 28(14). PMID: 25030692    Free PMC article.
Highly Cited. Review.
PVT1 dependence in cancer with MYC copy-number increase.
Yuen-Yi Tseng, Branden S Moriarity, +15 authors, Anindya Bagchi.
Nature, 2014 Jul 22; 512(7512). PMID: 25043044    Free PMC article.
Highly Cited.
Colocalization of β-catenin with Notch intracellular domain in colon cancer: a possible role of Notch1 signaling in activation of CyclinD1-mediated cell proliferation.
Natarajan Gopalakrishnan, Marimuthu Saravanakumar, +2 authors, Halagowder Devaraj.
Mol Cell Biochem, 2014 Jul 31; 396(1-2). PMID: 25073953
Neurotensin, a novel target of Wnt/β-catenin pathway, promotes growth of neuroendocrine tumor cells.
Ji Tae Kim, Chunming Liu, +3 authors, B Mark Evers.
Int J Cancer, 2014 Aug 08; 136(6). PMID: 25098665    Free PMC article.
Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis.
Cynthia L Sears, Abby L Geis, Franck Housseau.
J Clin Invest, 2014 Aug 12; 124(10). PMID: 25105360    Free PMC article.
Highly Cited. Review.
Activation of β-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis.
Mohammed Soutto, DunFa Peng, +6 authors, Wael El-Rifai.
Gut, 2014 Aug 12; 64(7). PMID: 25107557    Free PMC article.
Spontaneous genomic alterations in a chimeric model of colorectal cancer enable metastasis and guide effective combinatorial therapy.
Yinghui Zhou, William M Rideout, +13 authors, Joerg Heyer.
PLoS One, 2014 Aug 28; 9(8). PMID: 25162504    Free PMC article.
Gene Expression Profiling in Mouse Embryonic Stem Cells Reveals Glycogen Synthase Kinase-3-Dependent Targets of Phosphatidylinositol 3-Kinase and Wnt/β-Catenin Signaling Pathways.
Colleen M Bartman, Jennifer Egelston, +4 authors, Christopher J Phiel.
Front Endocrinol (Lausanne), 2014 Aug 29; 5. PMID: 25165462    Free PMC article.
Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28.
Phuong N Le, Jessica D McDermott, Antonio Jimeno.
Pharmacol Ther, 2014 Aug 31; 146. PMID: 25172549    Free PMC article.
Highly Cited. Review.
Updating the Wnt pathways.
Jia Yu, David M Virshup.
Biosci Rep, 2014 Sep 12; 34(5). PMID: 25208913    Free PMC article.
Crosstalk between microRNA30a/b/c/d/e-5p and the canonical Wnt pathway: implications for multiple myeloma therapy.
Jian-Jun Zhao, Ruben D Carrasco.
Cancer Res, 2014 Sep 18; 74(19). PMID: 25228654    Free PMC article.
Review.
Endostar, a modified recombinant human endostatin, suppresses angiogenesis through inhibition of Wnt/β-catenin signaling pathway.
Xiaoming Xu, Wei Mao, +5 authors, Zhaoquan Huang.
PLoS One, 2014 Sep 19; 9(9). PMID: 25232946    Free PMC article.
AXIN1 and AXIN2 variants in gastrointestinal cancers.
Serina M Mazzoni, Eric R Fearon.
Cancer Lett, 2014 Sep 23; 355(1). PMID: 25236910    Free PMC article.
Review.
Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut.
Maia Chanrion, Inna Kuperstein, +19 authors, Sylvie Robine.
Nat Commun, 2014 Oct 09; 5. PMID: 25295490    Free PMC article.
Iro/IRX transcription factors negatively regulate Dpp/TGF-β pathway activity during intestinal tumorigenesis.
Òscar Martorell, Francisco M Barriga, +5 authors, Andreu Casali.
EMBO Rep, 2014 Oct 10; 15(11). PMID: 25296644    Free PMC article.
Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice.
Jie Zuo, Daniel S Brewer, +2 authors, David H Phillips.
BMC Genomics, 2014 Oct 10; 15. PMID: 25297811    Free PMC article.
Frameshift Mutations (Deletion at Codon 1309 and Codon 849) in the APC Gene in Iranian FAP Patients: a Case Series and Review of the Literature.
Seyed Mohammad Hossein Kashfi, Faeghe Behboudi Farahbakhsh, +3 authors, Hamid Asadzadeh Aghdaie.
Int J Mol Cell Med, 2014 Oct 16; 3(3). PMID: 25317407    Free PMC article.
Activation of β-catenin signalling leads to temporomandibular joint defects.
M Wang, S Li, +6 authors, D Chen.
Eur Cell Mater, 2014 Oct 24; 28. PMID: 25340802    Free PMC article.
STAT3 paradoxically stimulates β-catenin expression but inhibits β-catenin function.
Salih Ibrahem, Saleh Al-Ghamdi, +5 authors, Mohammad Ilyas.
Int J Exp Pathol, 2014 Oct 29; 95(6). PMID: 25348333    Free PMC article.
Green tea polyphenol EGCG suppresses Wnt/β-catenin signaling by promoting GSK-3β- and PP2A-independent β-catenin phosphorylation/degradation.
Sangtaek Oh, Jungsug Gwak, Seoyoung Park, Chung S Yang.
Biofactors, 2014 Oct 30; 40(6). PMID: 25352148    Free PMC article.
The Wnt signalling cascade and the adherens junction complex in craniopharyngioma tumorigenesis.
Veronica Preda, Sarah J Larkin, +2 authors, Ashley B Grossman.
Endocr Pathol, 2014 Oct 31; 26(1). PMID: 25355426
MicroRNA-93 suppress colorectal cancer development via Wnt/β-catenin pathway downregulating.
Qingchao Tang, Zhaoxia Zou, +9 authors, Xishan Wang.
Tumour Biol, 2014 Nov 06; 36(3). PMID: 25371073
Hypothesis: cell signalling influences age-related risk of colorectal cancer.
Michael Bordonaro, Darina L Lazarova.
J Cell Mol Med, 2014 Nov 13; 19(1). PMID: 25388238    Free PMC article.
Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes.
Jan P Gerlach, Benjamin L Emmink, +2 authors, Madelon M Maurice.
Open Biol, 2014 Nov 14; 4(11). PMID: 25392450    Free PMC article.
Myofibroblast-derived SFRP1 as potential inhibitor of colorectal carcinoma field effect.
Gábor Valcz, Arpád V Patai, +10 authors, Zsolt Tulassay.
PLoS One, 2014 Nov 19; 9(11). PMID: 25405986    Free PMC article.
Nuclear factor-kappaB sensitizes to benzyl isothiocyanate-induced antiproliferation in p53-deficient colorectal cancer cells.
N Abe, D-X Hou, +2 authors, Y Nakamura.
Cell Death Dis, 2014 Nov 21; 5. PMID: 25412312    Free PMC article.
The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition.
Nate P Hoverter, Michael D Zeller, +6 authors, Marian L Waterman.
Nucleic Acids Res, 2014 Nov 22; 42(22). PMID: 25414359    Free PMC article.
Circadian rhythms, Wnt/beta-catenin pathway and PPAR alpha/gamma profiles in diseases with primary or secondary cardiac dysfunction.
Yves Lecarpentier, Victor Claes, Guillaume Duthoit, Jean-Louis Hébert.
Front Physiol, 2014 Nov 22; 5. PMID: 25414671    Free PMC article.
Review.
Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists.
Ana-Luisa Silva, Sarah N Dawson, +8 authors, Ashraf E K Ibrahim.
BMC Cancer, 2014 Nov 30; 14. PMID: 25432628    Free PMC article.
Krüppel-like factor 5 is essential for proliferation and survival of mouse intestinal epithelial stem cells.
Mandayam O Nandan, Amr M Ghaleb, Agnieszka B Bialkowska, Vincent W Yang.
Stem Cell Res, 2014 Dec 03; 14(1). PMID: 25460247    Free PMC article.
Cadherins in tissue architecture and disease.
Dietmar Vestweber.
J Mol Med (Berl), 2014 Dec 10; 93(1). PMID: 25488198
Somatic mosaicism in the human genome.
Donald Freed, Eric L Stevens, Jonathan Pevsner.
Genes (Basel), 2014 Dec 17; 5(4). PMID: 25513881    Free PMC article.
Review.
DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling.
Yuanzi Yu, Wenji Yan, +9 authors, Mingzhou Guo.
Am J Cancer Res, 2014 Dec 19; 4(6). PMID: 25520862    Free PMC article.
Anoikis of colon carcinoma cells triggered by β-catenin loss can be enhanced by tumor necrosis factor receptor 1 antagonists.
B H Yoo, O Masson, +3 authors, K V Rosen.
Oncogene, 2014 Dec 23; 34(38). PMID: 25531320
Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth.
Nan Li, Yajie Zhang, +9 authors, Junjie Chen.
Genes Dev, 2014 Dec 31; 29(2). PMID: 25547115    Free PMC article.
Genome-wide ChIP-seq analysis of TCF4 binding regions in colorectal cancer cells.
Chen Chen, Yachun Lu, +3 authors, Biaoyang Lin.
Int J Clin Exp Med, 2015 Jan 01; 7(11). PMID: 25550940    Free PMC article.
The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway.
Tomoko Uehara, Eriko Kage-Nakadai, +2 authors, Shohei Mitani.
PLoS Genet, 2015 Jan 09; 11(1). PMID: 25569233    Free PMC article.
Monitoring interactions and dynamics of endogenous beta-catenin with intracellular nanobodies in living cells.
Bjoern Traenkle, Felix Emele, +9 authors, Ulrich Rothbauer.
Mol Cell Proteomics, 2015 Jan 18; 14(3). PMID: 25595278    Free PMC article.
Phase II study of everolimus and letrozole in patients with recurrent endometrial carcinoma.
Brian M Slomovitz, Yunyun Jiang, +10 authors, Robert L Coleman.
J Clin Oncol, 2015 Jan 28; 33(8). PMID: 25624430    Free PMC article.
SMK-17, a MEK1/2-specific inhibitor, selectively induces apoptosis in β-catenin-mutated tumors.
Masaki Kiga, Ayako Nakayama, +5 authors, Masaya Imoto.
Sci Rep, 2015 Feb 03; 5. PMID: 25640451    Free PMC article.
Farnesoid X receptor associates with β-catenin and inhibits its activity in hepatocellular carcinoma.
Xijun Liu, Xingwang Zhang, +3 authors, She Chen.
Oncotarget, 2015 Feb 05; 6(6). PMID: 25650661    Free PMC article.
Clinico-Pathological Correlation of β-Catenin and Telomere Dysfunction in Head and Neck Squamous Cell Carcinoma Patients.
Swatishree Padhi, Arka Saha, +7 authors, Birendranath Banerjee.
J Cancer, 2015 Feb 06; 6(2). PMID: 25653721    Free PMC article.
The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts.
Zubaidah M Ramdzan, Ranjana Pal, +5 authors, Alain Nepveu.
Oncotarget, 2015 Feb 17; 6(6). PMID: 25682875    Free PMC article.
MicroRNA-153 promotes Wnt/β-catenin activation in hepatocellular carcinoma through suppression of WWOX.
Hong-Wei Hua, Feng Jiang, +2 authors, Gang Ding.
Oncotarget, 2015 Feb 25; 6(6). PMID: 25708809    Free PMC article.
Distinct human stem cell populations in small and large intestine.
Julie M Cramer, Timothy Thompson, +2 authors, Eric Lagasse.
PLoS One, 2015 Mar 10; 10(3). PMID: 25751518    Free PMC article.
A Protein Interaction between β-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells.
Jing Song, Zhanwen Du, +3 authors, Rob M Ewing.
Mol Cancer Res, 2015 Mar 11; 13(6). PMID: 25753001    Free PMC article.
Derricin and derricidin inhibit Wnt/β-catenin signaling and suppress colon cancer cell growth in vitro.
Barbara F Fonseca, Danilo Predes, +7 authors, Jose G Abreu.
PLoS One, 2015 Mar 17; 10(3). PMID: 25775405    Free PMC article.
The prognostic significance of β-catenin, cyclin D1 and PIN1 in minor salivary gland carcinoma: β-catenin predicts overall survival.
Sven Schneider, Dietmar Thurnher, +6 authors, Claudia Lill.
Eur Arch Otorhinolaryngol, 2015 Mar 25; 273(5). PMID: 25801951
Comparative analysis of the expression of E-cadherin, β-catenin, and β1 integrin in congenital and acquired cholesteatoma.
Dong Wook Lee, Jae Ho Chung, +4 authors, Ju Yeon Pyo.
Eur Arch Otorhinolaryngol, 2015 Apr 13; 273(4). PMID: 25864182
Inhibition of β-catenin signaling suppresses pancreatic tumor growth by disrupting nuclear β-catenin/TCF-1 complex: critical role of STAT-3.
Kartick C Pramanik, Neel M Fofaria, +3 authors, Sanjay K Srivastava.
Oncotarget, 2015 Apr 15; 6(13). PMID: 25869100    Free PMC article.
Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development.
Baojun Chang, Kandice L Tessneer, +13 authors, Hong Chen.
Nat Commun, 2015 Apr 15; 6. PMID: 25871009    Free PMC article.
Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma.
De-Chen Lin, Liang Xu, +11 authors, H Phillip Koeffler.
Cancer Res, 2015 Apr 17; 75(9). PMID: 25877876    Free PMC article.
The role of adherens junctions in the developing neocortex.
Adam M Stocker, Anjen Chenn.
Cell Adh Migr, 2015 Apr 29; 9(3). PMID: 25914082    Free PMC article.
Review.
Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial.
Sushma S Thomas, Karen W Makar, +10 authors, John D Potter.
BMC Med Genet, 2015 May 01; 16. PMID: 25927723    Free PMC article.
ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways.
Surendra Singh, John Arcaroli, +4 authors, Vasilis Vasiliou.
PLoS One, 2015 May 08; 10(5). PMID: 25950950    Free PMC article.
Novel isolated cecal pouch model for endoscopic observation in rats.
Kurodo Koshino, Nobuo Kanai, +2 authors, Masakazu Yamamoto.
World J Gastroenterol, 2015 May 09; 21(17). PMID: 25954097    Free PMC article.
TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal Cancer.
Jin Boo Jeong, Jihye Lee, Seong-Ho Lee.
Int J Mol Sci, 2015 May 12; 16(5). PMID: 25961950    Free PMC article.
Role of MCP-1 in alcohol-induced aggressiveness of colorectal cancer cells.
Mei Xu, Siying Wang, +6 authors, Jia Luo.
Mol Carcinog, 2015 May 28; 55(5). PMID: 26014148    Free PMC article.
Wnt/β-Catenin Signaling Regulates the Expression of the Ammonium Permease Gene RHBG in Human Cancer Cells.
Ahmad Merhi, Christelle De Mees, +2 authors, Anna Maria Marini.
PLoS One, 2015 Jun 02; 10(6). PMID: 26029888    Free PMC article.
Association of aberrant DNA methylation in Apc(min/+) mice with the epithelial-mesenchymal transition and Wnt/β-catenin pathways: genome-wide analysis using MeDIP-seq.
Yue Guo, Jong Hun Lee, +9 authors, Ah-Ng Tony Kong.
Cell Biosci, 2015 Jun 24; 5. PMID: 26101583    Free PMC article.
Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling.
Anna Toruń, Ewelina Szymańska, +6 authors, Marta Miaczynska.
PLoS One, 2015 Jun 26; 10(6). PMID: 26110841    Free PMC article.
Genomic analysis and selective small molecule inhibition identifies BCL-X(L) as a critical survival factor in a subset of colorectal cancer.
Haichao Zhang, John Xue, +6 authors, Lloyd T Lam.
Mol Cancer, 2015 Jul 03; 14. PMID: 26134786    Free PMC article.
Ubiquitin specific protease 4 positively regulates the WNT/β-catenin signaling in colorectal cancer.
Sun-Il Yun, Hyeon Ho Kim, +5 authors, Kyeong Kyu Kim.
Mol Oncol, 2015 Jul 21; 9(9). PMID: 26189775    Free PMC article.
β-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis.
Jing Cai, Anirban Maitra, +2 authors, Duojia Pan.
Genes Dev, 2015 Jul 22; 29(14). PMID: 26193883    Free PMC article.
Highly Cited.
CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer.
Michael Bordonaro, Darina L Lazarova.
World J Gastroenterol, 2015 Jul 29; 21(27). PMID: 26217075    Free PMC article.
Review.
Pleiotropic Activities of Vitamin D Receptors - Adequate Activation for Multiple Health Outcomes.
Jackson W Ryan, Paul H Anderson, Howard A Morris.
Clin Biochem Rev, 2015 Aug 01; 36(2). PMID: 26224895    Free PMC article.
Review.
Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells.
Linh M Vuong, Karthikeyani Chellappa, +8 authors, Frances M Sladek.
Mol Cell Biol, 2015 Aug 05; 35(20). PMID: 26240283    Free PMC article.
Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms.
Laura Novellasdemunt, Pedro Antas, Vivian S W Li.
Am J Physiol Cell Physiol, 2015 Aug 21; 309(8). PMID: 26289750    Free PMC article.
Highly Cited. Review.
Colorectal cancer models for novel drug discovery.
Daniel Golovko, Dmitriy Kedrin, Ömer H Yilmaz, Jatin Roper.
Expert Opin Drug Discov, 2015 Aug 22; 10(11). PMID: 26295972    Free PMC article.
Review.
Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.
Nan Li, Xi Chen, +12 authors, Gary A Piazza.
Oncotarget, 2015 Aug 25; 6(29). PMID: 26299804    Free PMC article.
APC is required for muscle stem cell proliferation and skeletal muscle tissue repair.
Alice Parisi, Floriane Lacour, +3 authors, Fabien Le Grand.
J Cell Biol, 2015 Aug 26; 210(5). PMID: 26304725    Free PMC article.
Targeting the WNT Signaling Pathway in Cancer Therapeutics.
David Tai, Keith Wells, +4 authors, Christopher H Lieu.
Oncologist, 2015 Aug 27; 20(10). PMID: 26306903    Free PMC article.
Review.
Canonical and noncanonical Wnt signaling in neural stem/progenitor cells.
Nora Bengoa-Vergniory, Robert M Kypta.
Cell Mol Life Sci, 2015 Aug 27; 72(21). PMID: 26306936
Review.
How do oncoprotein mutations rewire protein-protein interaction networks?
Emily H Bowler, Zhenghe Wang, Rob M Ewing.
Expert Rev Proteomics, 2015 Sep 02; 12(5). PMID: 26325016    Free PMC article.
Review.
Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis.
Satya Narayan, Ritika Sharma.
Life Sci, 2015 Sep 04; 139. PMID: 26334567    Free PMC article.
Review.
Development of anticancer agents targeting the Wnt/β-catenin signaling.
Xiangqian Zhang, Jijun Hao.
Am J Cancer Res, 2015 Sep 24; 5(8). PMID: 26396911    Free PMC article.
Review.
Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations.
Ada E D Teo, Sumedha Garg, +8 authors, Morris J Brown.
N Engl J Med, 2015 Sep 24; 373(15). PMID: 26397949    Free PMC article.
Resveratrol inhibits canonical Wnt signaling in human MG-63 osteosarcoma cells.
Yonggen Zou, Jiexiang Yang, Dianming Jiang.
Mol Med Rep, 2015 Sep 24; 12(5). PMID: 26398440    Free PMC article.
Mouse models of intestinal cancer.
Rene Jackstadt, Owen J Sansom.
J Pathol, 2015 Sep 29; 238(2). PMID: 26414675    Free PMC article.
Review.
The metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear β-catenin and CD44.
Xiongzhi Wangpu, Xiao Yang, +14 authors, Minhua Zheng.
Oncotarget, 2015 Sep 30; 6(32). PMID: 26418878    Free PMC article.
Long non-coding RNA profiling links subgroup classification of endometrioid endometrial carcinomas with trithorax and polycomb complex aberrations.
Yunyun Jiang, Gabriel G Malouf, +11 authors, Xiaoping Su.
Oncotarget, 2015 Oct 03; 6(37). PMID: 26431491    Free PMC article.
Gliotoxin Inhibits Proliferation and Induces Apoptosis in Colorectal Cancer Cells.
Junxiong Chen, Chenliang Wang, +7 authors, Huanliang Liu.
Mar Drugs, 2015 Oct 09; 13(10). PMID: 26445050    Free PMC article.
Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets.
Junyan Lu, Hanlin Zeng, +10 authors, Cheng Luo.
Sci Rep, 2015 Oct 09; 5. PMID: 26446703    Free PMC article.
Directly targeting transcriptional dysregulation in cancer.
Thomas J Gonda, Robert G Ramsay.
Nat Rev Cancer, 2015 Oct 24; 15(11). PMID: 26493648
Review.
Divergent Androgen Receptor and Beta-Catenin Signaling in Prostate Cancer Cells.
Eugine Lee, Susan Ha, Susan K Logan.
PLoS One, 2015 Oct 29; 10(10). PMID: 26509262    Free PMC article.
Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.
Aurélie Ladang, Francesca Rapino, +17 authors, Alain Chariot.
J Exp Med, 2015 Nov 04; 212(12). PMID: 26527802    Free PMC article.
Polyphenol Compound as a Transcription Factor Inhibitor.
Seyeon Park.
Nutrients, 2015 Nov 04; 7(11). PMID: 26529010    Free PMC article.
Review.
The Wnts of change: How Wnts regulate phenotype switching in melanoma.
Marie R Webster, Curtis H Kugel, Ashani T Weeraratna.
Biochim Biophys Acta, 2015 Nov 08; 1856(2). PMID: 26546268    Free PMC article.
Review.
miR-34a screened by miRNA profiling negatively regulates Wnt/β-catenin signaling pathway in Aflatoxin B1 induced hepatotoxicity.
Liye Zhu, Jing Gao, +3 authors, Wentao Xu.
Sci Rep, 2015 Nov 17; 5. PMID: 26567713    Free PMC article.
Identification of CTNNB1 mutations, CTNNB1 amplifications, and an Axin2 splice variant in juvenile angiofibromas.
Silke Wemmert, Vivienne Willnecker, +5 authors, Bernhard Schick.
Tumour Biol, 2015 Nov 18; 37(4). PMID: 26572152
Role of cancer stem cells in age-related rise in colorectal cancer.
Pratima Nangia-Makker, Yingjie Yu, Adhip Pn Majumdar.
World J Gastrointest Pathophysiol, 2015 Nov 26; 6(4). PMID: 26600965    Free PMC article.
Mensenchymal stem cells can delay radiation-induced crypt death: impact on intestinal CD44(+) fragments.
Peng-Yu Chang, Xing Jin, +3 authors, Jin Wang.
Cell Tissue Res, 2015 Nov 29; 364(2). PMID: 26613604    Free PMC article.
The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies.
Ke Yang, Xin Wang, +9 authors, Tong-Chuan He.
Lab Invest, 2015 Dec 01; 96(2). PMID: 26618721    Free PMC article.
Highly Cited.
Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy.
A Borah, S Raveendran, +2 authors, D S Kumar.
Oncogenesis, 2015 Dec 01; 4. PMID: 26619402    Free PMC article.
Review.
Expression of wingless-type mouse mammary tumor virus integration site family pathway effectors in lymphatic and hepatic metastases of patients with colorectal cancer: Associations with the primary tumor.
Sebastian Kraus, Christian Vay, +3 authors, Daniel Vallbohmer.
Oncol Lett, 2015 Dec 02; 10(2). PMID: 26622584    Free PMC article.
APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.
Kate M Mills, Mariana G Brocardo, Beric R Henderson.
Mol Biol Cell, 2015 Dec 15; 27(3). PMID: 26658612    Free PMC article.
Spatio-temporal genetic heterogeneity of CTNNB1 mutations in sporadic desmoid type fibromatosis lesions.
Jérôme Doyen, Valérie Duranton-Tanneur, +9 authors, Florence Pedeutour.
Virchows Arch, 2015 Dec 17; 468(3). PMID: 26666421
Treatment of LS174T colorectal cancer stem-like cells with n-3 PUFAs induces growth suppression through inhibition of survivin expression and induction of caspase-3 activation.
Mohammad Reza Sam, Parinaz Ahangar, Vahid Nejati, Reza Habibian.
Cell Oncol (Dordr), 2015 Dec 17; 39(1). PMID: 26671842
β-Catenin, a Transcription Factor Activated by Canonical Wnt Signaling, Is Expressed in Sensory Neurons of Calves Latently Infected with Bovine Herpesvirus 1.
Yilin Liu, Morgan Hancock, +2 authors, Clinton Jones.
J Virol, 2016 Jan 08; 90(6). PMID: 26739046    Free PMC article.
Adenomatous polyposis coli genotype-dependent toll-like receptor 4 activity in colon cancer.
Feng Wen, Yongmei Liu, +6 authors, Qiu Li.
Oncotarget, 2016 Jan 14; 7(7). PMID: 26760960    Free PMC article.
Adenomatous polyposis coli (APC) regulates miR17-92 cluster through β-catenin pathway in colorectal cancer.
Yajuan Li, Mattia Lauriola, +8 authors, Jin Q Cheng.
Oncogene, 2016 Jan 26; 35(35). PMID: 26804172    Free PMC article.
Activating mutations in CTNNB1 in aldosterone producing adenomas.
Tobias Åkerström, Rajani Maharjan, +13 authors, Peyman Björklund.
Sci Rep, 2016 Jan 28; 6. PMID: 26815163    Free PMC article.
Highly Cited.
Identification of quinazoline compounds as novel potent inhibitors of Wnt/β-catenin signaling in colorectal cancer cells.
Yonghe Li, Wenyan Lu, +3 authors, Subramaniam Ananthan.
Oncotarget, 2016 Jan 29; 7(10). PMID: 26820295    Free PMC article.
Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway.
Xuefang Wu, Feng Luo, +2 authors, Kunping Liu.
Int J Oncol, 2016 Jan 29; 48(4). PMID: 26820603    Free PMC article.
p300/β-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC).
Megan E Rieger, Beiyun Zhou, +10 authors, Zea Borok.
J Biol Chem, 2016 Feb 03; 291(12). PMID: 26833564    Free PMC article.
KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.
Amr M Ghaleb, Enas A Elkarim, Agnieszka B Bialkowska, Vincent W Yang.
Mol Cancer Res, 2016 Feb 04; 14(4). PMID: 26839262    Free PMC article.
Bibliometric analysis of the top-cited gastroenterology and hepatology articles.
Samy A Azer, Sarah Azer.
BMJ Open, 2016 Feb 10; 6(2). PMID: 26857105    Free PMC article.
Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24.
Michihiro Yoshida, Luqing Zhao, +3 authors, C Chris Yun.
Am J Physiol Gastrointest Liver Physiol, 2016 Feb 13; 310(8). PMID: 26867566    Free PMC article.
Genetic analysis of intestinal polyp development in Collaborative Cross mice carrying the Apc (Min/+) mutation.
Alexandra Dorman, Daria Baer, +2 authors, Fuad A Iraqi.
BMC Genet, 2016 Feb 21; 17. PMID: 26896154    Free PMC article.
Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/β-catenin signaling.
Guandou Yuan, Bixiang Zhang, +5 authors, Pran K Datta.
Oncotarget, 2016 Feb 26; 7(13). PMID: 26910283    Free PMC article.
Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation.
Yaohui Chen, Yu Li, +8 authors, Suyun Huang.
EMBO J, 2016 Feb 26; 35(6). PMID: 26912724    Free PMC article.
Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta.
Estefania Martino-Echarri, Mariana G Brocardo, Kate M Mills, Beric R Henderson.
PLoS One, 2016 Mar 02; 11(3). PMID: 26930278    Free PMC article.
Sef Regulates Epithelial-Mesenchymal Transition in Breast Cancer Cells.
Qing He, Yan Gong, +2 authors, Robert E Friesel.
J Cell Biochem, 2016 Mar 08; 117(10). PMID: 26950413    Free PMC article.
Olfactomedin 4 deletion induces colon adenocarcinoma in ApcMin/+ mice.
W Liu, H Li, +3 authors, G P Rodgers.
Oncogene, 2016 Mar 15; 35(40). PMID: 26973250    Free PMC article.
The Role of Chromosomal Instability and Epigenetics in Colorectal Cancers Lacking β-Catenin/TCF Regulated Transcription.
Wael M Abdel-Rahman, Johanna E Lotsari-Salomaa, +5 authors, Päivi Peltomäki.
Gastroenterol Res Pract, 2016 Apr 06; 2016. PMID: 27047543    Free PMC article.
Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics.
Zachary C Poss, Christopher C Ebmeier, +7 authors, Dylan J Taatjes.
Cell Rep, 2016 Apr 07; 15(2). PMID: 27050516    Free PMC article.
Highly Cited.
Highly sensitive, non-invasive detection of colorectal cancer mutations using single molecule, third generation sequencing.
Giancarlo Russo, Andrea Patrignani, +4 authors, Alex M Garvin.
Appl Transl Genom, 2016 Apr 08; 7. PMID: 27054083    Free PMC article.
The novel tankyrase inhibitor (AZ1366) enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance.
Kevin S Quackenbush, Stacey Bagby, +14 authors, John J Arcaroli.
Oncotarget, 2016 Apr 14; 7(19). PMID: 27070088    Free PMC article.
Vimentin, colon cancer progression and resistance to butyrate and other HDACis.
Darina L Lazarova, Michael Bordonaro.
J Cell Mol Med, 2016 Apr 14; 20(6). PMID: 27072512    Free PMC article.
Review.
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance.
Maryam K Mohammed, Connie Shao, +16 authors, Michael J Lee.
Genes Dis, 2016 Apr 15; 3(1). PMID: 27077077    Free PMC article.
Highly Cited.
Diverse Basis of β-Catenin Activation in Human Hepatocellular Carcinoma: Implications in Biology and Prognosis.
Hirohisa Okabe, Hiroki Kinoshita, +13 authors, Yoshihiko Maehara.
PLoS One, 2016 Apr 23; 11(4). PMID: 27100093    Free PMC article.
Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling.
Carmen Oi-Ning Leung, Wing-Nga Mak, +4 authors, Regina Cheuk-Lam Lo.
Oncotarget, 2016 Apr 23; 7(20). PMID: 27105493    Free PMC article.
Two variants on T2DM susceptible gene HHEX are associated with CRC risk in a Chinese population.
Rui Sun, Jian-Ping Liu, +9 authors, Jue-Ping Feng.
Oncotarget, 2016 Apr 23; 7(20). PMID: 27105501    Free PMC article.
Mechanistic roles of epithelial and immune cell signaling during the development of colitis-associated cancer.
Renuka Subramaniam, Atsushi Mizoguchi, Emiko Mizoguchi.
Cancer Res Front, 2016 Apr 26; 2(1). PMID: 27110580    Free PMC article.
HIF-1α activates hypoxia-induced BCL-9 expression in human colorectal cancer cells.
Zhen Tan, Quan Huang, +11 authors, Jian-Ru Xiao.
Oncotarget, 2016 Apr 29; 8(16). PMID: 27121066    Free PMC article.
AURKA induces EMT by regulating histone modification through Wnt/β-catenin and PI3K/Akt signaling pathway in gastric cancer.
Xi Liu, Zhaoxia Li, +6 authors, Qingyu Zhang.
Oncotarget, 2016 Apr 29; 7(22). PMID: 27121204    Free PMC article.
An enduring role for quiescent stem cells.
Camilla A Richmond, Manasvi S Shah, Diana L Carlone, David T Breault.
Dev Dyn, 2016 May 07; 245(7). PMID: 27153394    Free PMC article.
Review.
The role of Wnt/β-catenin signaling pathway in melanoma epithelial-to-mesenchymal-like switching: evidences from patients-derived cell lines.
Daniela Kovacs, Emilia Migliano, +4 authors, Barbara Bellei.
Oncotarget, 2016 May 14; 7(28). PMID: 27175588    Free PMC article.
Determination of the Role of CBP- and p300-Mediated Wnt Signaling on Colonic Cells.
Michael Bordonaro, Darina Lazarova Lazarova.
JMIR Res Protoc, 2016 May 15; 5(2). PMID: 27177606    Free PMC article.
The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila.
Zhenghan Wang, Ai Tian, +4 authors, Yashi Ahmed.
Development, 2016 May 18; 143(10). PMID: 27190037    Free PMC article.
Cancer comes of age embryonically.
Vi K Chiu, Anne-France Le Rolle.
Aging (Albany NY), 2016 May 19; 8(5). PMID: 27191151    Free PMC article.
Expression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon Cancer.
Ozkan Ozden, Faraz Bishehsari, +8 authors, Barbara Jung.
Sci Rep, 2016 May 21; 6. PMID: 27197561    Free PMC article.
Construction and Experimental Validation of a Petri Net Model of Wnt/β-Catenin Signaling.
Annika Jacobsen, Nika Heijmans, +4 authors, K Anton Feenstra.
PLoS One, 2016 May 25; 11(5). PMID: 27218469    Free PMC article.
Growth hormone is permissive for neoplastic colon growth.
Vera Chesnokova, Svetlana Zonis, +9 authors, Shlomo Melmed.
Proc Natl Acad Sci U S A, 2016 May 27; 113(23). PMID: 27226307    Free PMC article.
Refining Pathways: A Model Comparison Approach.
Giusi Moffa, Gerrit Erdmann, +4 authors, Rainer Spang.
PLoS One, 2016 Jun 02; 11(6). PMID: 27248690    Free PMC article.
Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling.
So-Young Hwang, Xianming Deng, +9 authors, Sam W Lee.
Cell Rep, 2016 Jun 21; 16(1). PMID: 27320923    Free PMC article.
Molecular pathological classification of colorectal cancer.
Mike F Müller, Ashraf E K Ibrahim, Mark J Arends.
Virchows Arch, 2016 Jun 22; 469(2). PMID: 27325016    Free PMC article.
Highly Cited. Review.
Metacycloprodigiosin induced cell death selectively in β-catenin-mutated tumor cells.
Hiroaki Ikeda, Yuki Shikata, +2 authors, Masaya Imoto.
J Antibiot (Tokyo), 2016 Jun 23; 70(1). PMID: 27328865
Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration.
Dikshya Bastakoty, Pampee P Young.
FASEB J, 2016 Jun 24; 30(10). PMID: 27335371    Free PMC article.
Review.
Methylation status of the APC and RASSF1A promoter in cell-free circulating DNA and its prognostic role in patients with colorectal cancer.
Dimitrios Matthaios, Ioanna Balgkouranidou, +9 authors, Stylianos Kakolyris.
Oncol Lett, 2016 Jun 28; 12(1). PMID: 27347211    Free PMC article.
MicroRNA-142-3p Negatively Regulates Canonical Wnt Signaling Pathway.
Tanyu Hu, Krung Phiwpan, +7 authors, Xuyu Zhou.
PLoS One, 2016 Jun 28; 11(6). PMID: 27348426    Free PMC article.
Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin.
Shanthi Ganesh, Martin L Koser, +15 authors, Marc T Abrams.
Mol Cancer Ther, 2016 Jul 09; 15(9). PMID: 27390343    Free PMC article.
Biological characterization of bovine mammary epithelial cell lines immortalized by HPV16 E6/E7 and SV40T.
Kang Zhan, Miao Lin, +2 authors, Guo-Qi Zhao.
In Vitro Cell Dev Biol Anim, 2016 Oct 22; 52(9). PMID: 27412498
Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer.
Michael A Mcilhatton, Gregory P Boivin, Joanna Groden.
Biomed Res Int, 2016 Jul 15; 2016. PMID: 27413734    Free PMC article.
Review.
Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer.
Justin M Drake, Evan O Paull, +17 authors, Joshua M Stuart.
Cell, 2016 Aug 09; 166(4). PMID: 27499020    Free PMC article.
Highly Cited.
Orthokeratinized Odontogenic Cyst with an Associated Keratocystic Odontogenic Tumor Component and Ghost Cell Keratinization and Calcifications in a Patient with Gardner Syndrome.
Prokopios P Argyris, Ioannis G Koutlas.
Head Neck Pathol, 2016 Aug 10; 11(2). PMID: 27501963    Free PMC article.
G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway.
Shih-Ting Cha, Ching-Ting Tan, +5 authors, Min-Liang Kuo.
Nat Cell Biol, 2016 Aug 16; 18(9). PMID: 27525719
Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma.
F Linke, M Harenberg, +18 authors, D Kube.
Leukemia, 2016 Aug 19; 31(2). PMID: 27535218
Novel β-carbolines against colorectal cancer cell growth via inhibition of Wnt/β-catenin signaling.
X Li, B Bai, +9 authors, Y Li.
Cell Death Discov, 2015 Jan 01; 1. PMID: 27551464    Free PMC article.
TNIK inhibition abrogates colorectal cancer stemness.
Mari Masuda, Yuko Uno, +11 authors, Tesshi Yamada.
Nat Commun, 2016 Aug 27; 7. PMID: 27562646    Free PMC article.
Two subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis.
Kiyoko Takane, Keisuke Matsusaka, +12 authors, Atsushi Kaneda.
Oncotarget, 2016 Aug 27; 7(51). PMID: 27563825    Free PMC article.
Regulation of CTNNB1 signaling in gastric cancer and stem cells.
Shihori Tanabe, Kazuhiko Aoyagi, Hiroshi Yokozaki, Hiroki Sasaki.
World J Gastrointest Oncol, 2016 Aug 31; 8(8). PMID: 27574551    Free PMC article.
Review.
Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer.
I-Chien Chen, Kuen-Haur Lee, +3 authors, Ya-Wen Cheng.
Dis Markers, 2016 Sep 01; 2016. PMID: 27578919    Free PMC article.
Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin.
Jessica Chinison, Jose S Aguilar, +4 authors, Jijun Hao.
Sci Rep, 2016 Sep 07; 6. PMID: 27596363    Free PMC article.
Decreased expression of CDH1 or CTNNB1 affects poor prognosis of patients with esophageal cancer.
Hideyuki Ishiguro, Takehiro Wakasugi, +6 authors, Hiromitsu Takeyama.
World J Surg Oncol, 2016 Sep 08; 14(1). PMID: 27600761    Free PMC article.
Immunotherapy in human colorectal cancer: Challenges and prospective.
Xuan Sun, Jian Suo, Jun Yan.
World J Gastroenterol, 2016 Sep 09; 22(28). PMID: 27605872    Free PMC article.
Review.
Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model.
Tara Williamson, Ren-Yuan Bai, +2 authors, Gregory J Riggins.
Oncotarget, 2016 Sep 11; 7(42). PMID: 27612418    Free PMC article.
Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis.
S Liu, N R Tackmann, J Yang, Y Zhang.
Oncogene, 2016 Sep 13; 36(10). PMID: 27617574    Free PMC article.
Favorable prognosis in colorectal cancer patients with co-expression of c-MYC and ß-catenin.
Kyu Sang Lee, Yoonjin Kwak, +5 authors, Hye Seung Lee.
BMC Cancer, 2016 Sep 14; 16(1). PMID: 27619912    Free PMC article.
RNF4-Dependent Oncogene Activation by Protein Stabilization.
Jane J Thomas, Mona Abed, +11 authors, Amir Orian.
Cell Rep, 2016 Sep 23; 16(12). PMID: 27653698    Free PMC article.
AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non-Small Cell Lung Cancer Cells Following EGFR Inhibition.
Hannah A Scarborough, Barbara A Helfrich, +9 authors, James DeGregori.
Clin Cancer Res, 2016 Sep 25; 23(6). PMID: 27663586    Free PMC article.
A Dynamic WNT/β-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells.
Alana M Chin, Yu-Hwai Tsai, +6 authors, Jason R Spence.
Stem Cell Reports, 2016 Oct 11; 7(5). PMID: 27720905    Free PMC article.
Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability.
Yao Fong, Chia-Chun Tang, +8 authors, Chien-Chih Chiu.
Chin Med, 2016 Oct 14; 11. PMID: 27733866    Free PMC article.
Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway.
Issei Egashira, Fumi Takahashi-Yanaga, +8 authors, Toshiyuki Sasaguri.
Cancer Sci, 2016 Oct 21; 108(1). PMID: 27761963    Free PMC article.
Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase.
Kosuke Toda, Kenji Kawada, +5 authors, Yoshiharu Sakai.
Neoplasia, 2016 Oct 21; 18(11). PMID: 27764698    Free PMC article.
Elevation of n-3/n-6 PUFAs ratio suppresses mTORC1 and prevents colorectal carcinogenesis associated with APC mutation.
Miao Liu, Ling Zhou, +9 authors, Hang Zheng.
Oncotarget, 2016 Oct 22; 7(47). PMID: 27769066    Free PMC article.
Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis.
Blair W Benham-Pyle, Joo Yong Sim, +2 authors, William James Nelson.
Elife, 2016 Oct 27; 5. PMID: 27782880    Free PMC article.
The crosstalk between microRNAs and the Wnt/β-catenin signaling pathway in cancer.
Yin Peng, Xiaojing Zhang, +2 authors, Zhe Jin.
Oncotarget, 2016 Oct 30; 8(8). PMID: 27793042    Free PMC article.
Review.
Cancer driver gene discovery through an integrative genomics approach in a non-parametric Bayesian framework.
Hai Yang, Qiang Wei, +2 authors, Bingshan Li.
Bioinformatics, 2016 Nov 01; 33(4). PMID: 27797769    Free PMC article.
The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer.
Sofia Winslow, Kajsa Ericson Lindquist, Anders Edsjö, Christer Larsson.
BMC Cancer, 2016 Nov 05; 16(1). PMID: 27809802    Free PMC article.
The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression.
Suranand B Talla, Felix H Brembeck.
Oncotarget, 2016 Nov 05; 7(49). PMID: 27811361    Free PMC article.
Modulation of Inflammatory Responses by Wnt/β-Catenin Signaling in Dendritic Cells: A Novel Immunotherapy Target for Autoimmunity and Cancer.
Amol Suryawanshi, Raghu K Tadagavadi, Daniel Swafford, Santhakumar Manicassamy.
Front Immunol, 2016 Nov 12; 7. PMID: 27833613    Free PMC article.
Review.
Evolutionary biologic changes of gut microbiota in an 'adenoma-carcinoma sequence' mouse colorectal cancer model induced by 1, 2-Dimethylhydrazine.
Teng Sun, Shanglong Liu, +8 authors, Song Wang.
Oncotarget, 2016 Nov 24; 8(1). PMID: 27880935    Free PMC article.
Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium.
Nils W Engel, Julia E Neumann, +4 authors, Ulrich Schüller.
PLoS One, 2016 Dec 03; 11(11). PMID: 27902722    Free PMC article.
Clinicopathological significance of WIF1 hypermethylation in NSCLC, a meta-analysis and literature review.
Hao Guo, Shuni Zhou, +3 authors, Ruizhi Ran.
Oncotarget, 2016 Dec 03; 8(2). PMID: 27911280    Free PMC article.
Review.
The more the messier: centrosome amplification as a novel biomarker for personalized treatment of colorectal cancers.
Monica M Mahathre, Padmashree Cg Rida, Ritu Aneja.
J Biomed Res, 2016 Dec 08; 30(6). PMID: 27924065    Free PMC article.
Review.
FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway.
Kun Li, Qunfeng Guo, +8 authors, Lei Li.
Oncotarget, 2016 Dec 08; 8(3). PMID: 27926503    Free PMC article.
Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis.
Shizhen Zhang, Zhen Wang, +6 authors, Xiaochen Wang.
Medicine (Baltimore), 2016 Dec 09; 95(49). PMID: 27930552    Free PMC article.
LEF1 reduces tumor progression and induces myodifferentiation in a subset of rhabdomyosarcoma.
Julia Dräger, Katja Simon-Keller, +8 authors, Heidi Hahn.
Oncotarget, 2016 Dec 15; 8(2). PMID: 27965462    Free PMC article.
Potential Role for a β-Catenin Coactivator (High-Mobility Group AT-Hook 1 Protein) during the Latency-Reactivation Cycle of Bovine Herpesvirus 1.
Liqian Zhu, Aspen Workman, Clinton Jones.
J Virol, 2016 Dec 23; 91(5). PMID: 28003484    Free PMC article.
SRI36160 is a specific inhibitor of Wnt/β-catenin signaling in human pancreatic and colorectal cancer cells.
Yonghe Li, Patsy G Oliver, +5 authors, Mark J Suto.
Cancer Lett, 2017 Jan 04; 389. PMID: 28043913    Free PMC article.
Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior.
Kyoichi Hashimoto, Yosuke Yamada, +10 authors, Yasuhiro Yamada.
Proc Natl Acad Sci U S A, 2017 Jan 07; 114(4). PMID: 28057861    Free PMC article.
Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.
Daniel O Kechele, R Eric Blue, +8 authors, Kathleen M Caron.
J Clin Invest, 2017 Jan 18; 127(2). PMID: 28094771    Free PMC article.
Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions.
Gabriele Picco, Consalvo Petti, +6 authors, Enzo Medico.
EMBO Mol Med, 2017 Jan 20; 9(3). PMID: 28100566    Free PMC article.
A novel microRNA located in the TrkC gene regulates the Wnt signaling pathway and is differentially expressed in colorectal cancer specimens.
Sadat Dokanehiifard, Atena Yasari, +4 authors, Bahram M Soltani.
J Biol Chem, 2017 Jan 20; 292(18). PMID: 28100780    Free PMC article.
The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes.
Vin-Cent Wu, Shuo-Meng Wang, +9 authors, Kwan-Dun Wu.
Sci Rep, 2017 Jan 20; 7. PMID: 28102204    Free PMC article.
Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation.
Tor Espen Thorvaldsen, Nina Marie Pedersen, Eva Maria Wenzel, Harald Stenmark.
PLoS One, 2017 Jan 21; 12(1). PMID: 28107521    Free PMC article.
Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells.
Yuki Shikata, Masaki Kiga, +5 authors, Masaya Imoto.
Cancer Sci, 2017 Jan 21; 108(4). PMID: 28107588    Free PMC article.
Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer.
Rehan Ahmad, Maroof Alam, +4 authors, Donald Kufe.
Mol Cancer, 2017 Feb 06; 16(1). PMID: 28153010    Free PMC article.
miR-320a functions as a suppressor for gliomas by targeting SND1 and β-catenin, and predicts the prognosis of patients.
Huining Li, Lin Yu, +12 authors, Shizhu Yu.
Oncotarget, 2017 Feb 06; 8(12). PMID: 28160566    Free PMC article.
Multiscale mutation clustering algorithm identifies pan-cancer mutational clusters associated with pathway-level changes in gene expression.
William Poole, Kalle Leinonen, +2 authors, Brady Bernard.
PLoS Comput Biol, 2017 Feb 09; 13(2). PMID: 28170390    Free PMC article.
An approach to infer putative disease-specific mechanisms using neighboring gene networks.
Sahar Ansari, Michele Donato, Nafiseh Saberian, Sorin Draghici.
Bioinformatics, 2017 Feb 16; 33(13). PMID: 28200075    Free PMC article.
The role of beta-catenin mutation and SOX9 expression in sex cord-stromal tumours of the testis.
F Bremmer, C L Behnes, +6 authors, S Schweyer.
Virchows Arch, 2017 Feb 17; 470(4). PMID: 28204871
Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors.
Rong Wang, Ying-Shiuan Chen, +6 authors, Roderick H Dashwood.
Mol Carcinog, 2017 Feb 22; 56(7). PMID: 28218467    Free PMC article.
Tissue transglutaminase induces Epithelial-Mesenchymal-Transition and the acquisition of stem cell like characteristics in colorectal cancer cells.
Oluseyi Ayinde, Zhuo Wang, Martin Griffin.
Oncotarget, 2017 Feb 23; 8(12). PMID: 28223538    Free PMC article.
Nucleic acid sensing pattern recognition receptors in the development of colorectal cancer and colitis.
Liangmei He, Yayun Chen, +3 authors, Zhiping Liu.
Cell Mol Life Sci, 2017 Feb 23; 74(13). PMID: 28224203
Review.
Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways.
Yan-Jiun Huang, Ching-Kuo Yang, +7 authors, Yun Yen.
J Hematol Oncol, 2017 Mar 01; 10(1). PMID: 28241877    Free PMC article.
MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications.
Ashlee M Strubberg, Blair B Madison.
Dis Model Mech, 2017 Mar 03; 10(3). PMID: 28250048    Free PMC article.
Review.
Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia.
Zheng Chen, Mohammed Soutto, +7 authors, Wael El-Rifai.
Genes Chromosomes Cancer, 2017 Mar 11; 56(7). PMID: 28281307    Free PMC article.
Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome.
G V Walls, M Stevenson, +12 authors, R V Thakker.
Oncogene, 2017 Mar 14; 36(28). PMID: 28288139    Free PMC article.
Beta-catenin Forms Protein Aggregation at High Concentrations in HEK293TCells.
Marie Saghaeian Jazi, Seyed Mahmoud Arab Najafi.
Iran J Med Sci, 2017 Mar 16; 42(1). PMID: 28293052    Free PMC article.
Correlations between TBL1XR1 and recurrence of colorectal cancer.
Hongda Liu, Yunfei Xu, +8 authors, Yuxin Chen.
Sci Rep, 2017 Mar 16; 7. PMID: 28295012    Free PMC article.
Highly Cited.
Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer.
Yves Lecarpentier, Victor Claes, Alexandre Vallée, Jean-Louis Hébert.
PPAR Res, 2017 Mar 17; 2017. PMID: 28298922    Free PMC article.
Review.
Endothelial NO Synthase-Dependent S-Nitrosylation of β-Catenin Prevents Its Association with TCF4 and Inhibits Proliferation of Endothelial Cells Stimulated by Wnt3a.
Ying Zhang, Rony Chidiac, Chantal Delisle, Jean-Philippe Gratton.
Mol Cell Biol, 2017 Mar 23; 37(12). PMID: 28320874    Free PMC article.
Emerging role of chemoprotective agents in the dynamic shaping of plasma membrane organization.
Natividad R Fuentes, Michael L Salinas, Eunjoo Kim, Robert S Chapkin.
Biochim Biophys Acta Biomembr, 2017 Mar 28; 1859(9 Pt B). PMID: 28342710    Free PMC article.
Review.
Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).
Shivaani Kummar, Geraldine O'Sullivan Coyne, +14 authors, Alice P Chen.
J Clin Oncol, 2017 Mar 30; 35(14). PMID: 28350521    Free PMC article.
Highly Cited.
New Insights toward Colorectal Cancer Chemotherapy Using Natural Bioactive Compounds.
Saúl Redondo-Blanco, Javier Fernández, +2 authors, Felipe Lombó.
Front Pharmacol, 2017 Mar 30; 8. PMID: 28352231    Free PMC article.
Review.
Medulloblastoma: Molecular Classification-Based Personal Therapeutics.
Tenley C Archer, Elizabeth L Mahoney, Scott L Pomeroy.
Neurotherapeutics, 2017 Apr 08; 14(2). PMID: 28386677    Free PMC article.
Review.
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Francesco Fallo, Isabella Castellano, +9 authors, Martin Reincke.
Endocrine, 2017 Apr 14; 58(3). PMID: 28405879    Free PMC article.
Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta-catenin pathway.
Yves Lecarpentier, Victor Claes, Alexandre Vallée, Jean-Louis Hébert.
Clin Transl Med, 2017 Apr 14; 6(1). PMID: 28405929    Free PMC article.
Review.
A central role for cadherin signaling in cancer.
Antonis Kourtidis, Ruifeng Lu, Lindy J Pence, Panos Z Anastasiadis.
Exp Cell Res, 2017 Apr 17; 358(1). PMID: 28412244    Free PMC article.
Highly Cited. Review.
Reciprocal control of lncRNA-BCAT1 and β-catenin pathway reveals lncRNA-BCAT1 long non-coding RNA acts as a tumor suppressor in colorectal cancer.
Fei Xie, Xudong Xiang, +7 authors, Shangyong Zheng.
Oncotarget, 2017 Apr 19; 8(14). PMID: 28416735    Free PMC article.
Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis.
Zackie Aktary, Mahsa Alaee, Manijeh Pasdar.
Oncotarget, 2017 Apr 19; 8(19). PMID: 28416759    Free PMC article.
Review.
The regulation of β-catenin activity and function in cancer: therapeutic opportunities.
Shuang Shang, Fang Hua, Zhuo-Wei Hu.
Oncotarget, 2017 Apr 22; 8(20). PMID: 28430641    Free PMC article.
Highly Cited. Review.
KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling.
Jiong Li, Bo Yu, +7 authors, Cun-Yu Wang.
Nat Commun, 2017 Apr 26; 8. PMID: 28440295    Free PMC article.
Interleukin-37 mediates the antitumor activity in colon cancer through β-catenin suppression.
Xiaofei Yan, Jian Zhao, Rui Zhang.
Oncotarget, 2017 May 04; 8(30). PMID: 28467774    Free PMC article.
Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice.
Rikako Ishigamori, Masami Komiya, +3 authors, Mami Takahashi.
Int J Mol Sci, 2017 May 16; 18(5). PMID: 28505114    Free PMC article.
Nuclear expression of TCF4/TCF7L2 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma.
Hideyuki Ishiguro, Takehiro Wakasugi, +5 authors, Hiromitsu Takeyama.
Cell Mol Biol Lett, 2017 May 26; 21. PMID: 28536608    Free PMC article.
The identification and validation of Trichosstatin A as a potential inhibitor of colon tumorigenesis and colon cancer stem-like cells.
Tse-Hung Huang, Szu-Yuan Wu, +3 authors, Tsu-Yi Chao.
Am J Cancer Res, 2017 Jun 01; 7(5). PMID: 28560069    Free PMC article.
U94 of human herpesvirus 6 down-modulates Src, promotes a partial mesenchymal-to-epithelial transition and inhibits tumor cell growth, invasion and metastasis.
Francesca Caccuri, Roberto Ronca, +12 authors, Arnaldo Caruso.
Oncotarget, 2017 Jun 01; 8(27). PMID: 28562350    Free PMC article.
MYC Deregulation in Primary Human Cancers.
Manpreet Kalkat, Jason De Melo, +6 authors, Linda Z Penn.
Genes (Basel), 2017 Jun 08; 8(6). PMID: 28587062    Free PMC article.
Highly Cited. Review.
Developmental pathways associated with cancer metastasis: Notch, Wnt, and Hedgehog.
Armel Herve Nwabo Kamdje, Paul Takam Kamga, +8 authors, Mauro Krampera.
Cancer Biol Med, 2017 Jun 14; 14(2). PMID: 28607802    Free PMC article.
Depletion of p21-activated kinase 1 up-regulates the immune system of APC∆14/+ mice and inhibits intestinal tumorigenesis.
Nhi Huynh, Kai Wang, +5 authors, Hong He.
BMC Cancer, 2017 Jun 21; 17(1). PMID: 28629331    Free PMC article.
Molecular regulation and pharmacological targeting of the β-catenin destruction complex.
Eline C van Kappel, Madelon M Maurice.
Br J Pharmacol, 2017 Jun 22; 174(24). PMID: 28634996    Free PMC article.
Review.
ZEB1 Mediates Drug Resistance and EMT in p300-Deficient CRC.
Darina Lazarova, Michael Bordonaro.
J Cancer, 2017 Jun 24; 8(8). PMID: 28638460    Free PMC article.
Potentiating the effects of radiotherapy in rectal cancer: the role of aspirin, statins and metformin as adjuncts to therapy.
K J Gash, A C Chambers, +2 authors, M G Thomas.
Br J Cancer, 2017 Jun 24; 117(2). PMID: 28641310    Free PMC article.
PHF21B overexpression promotes cancer stem cell-like traits in prostate cancer cells by activating the Wnt/β-catenin signaling pathway.
Qiji Li, Liping Ye, +3 authors, Xinsheng Peng.
J Exp Clin Cancer Res, 2017 Jun 25; 36(1). PMID: 28645312    Free PMC article.
Chronic Trichuris muris infection causes neoplastic change in the intestine and exacerbates tumour formation in APC min/+ mice.
Kelly S Hayes, Laura J Cliffe, +4 authors, Richard K Grencis.
PLoS Negl Trop Dis, 2017 Jun 27; 11(6). PMID: 28650985    Free PMC article.
Suppression Of β-catenin Nuclear Translocation By CGP57380 Decelerates Poor Progression And Potentiates Radiation-Induced Apoptosis in Nasopharyngeal Carcinoma.
Weiyuan Wang, Qiuyuan Wen, +8 authors, Songqing Fan.
Theranostics, 2017 Jun 29; 7(7). PMID: 28656063    Free PMC article.
Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/β-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer.
Shili Xiang, Tingxiu Xiang, +3 authors, Tao Luo.
Int J Oncol, 2017 Jul 06; 51(3). PMID: 28677721    Free PMC article.
Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.
Joshua E Flack, Juliusz Mieszczanek, Nikola Novcic, Mariann Bienz.
Mol Cell, 2017 Jul 12; 67(2). PMID: 28689657    Free PMC article.
Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.
Ai Tian, Hassina Benchabane, +8 authors, Yashi Ahmed.
PLoS Genet, 2017 Jul 15; 13(7). PMID: 28708826    Free PMC article.
Pathogenetic Analysis of Sinonasal Teratocarcinosarcomas Reveal Actionable β-catenin Overexpression and a β-catenin Mutation.
Andrew C Birkeland, Sarah J Burgin, +8 authors, J Chad Brenner.
J Neurol Surg B Skull Base, 2017 Jul 21; 78(4). PMID: 28725522    Free PMC article.
Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling.
R Ahmad, B Kumar, +7 authors, A B Singh.
Oncogene, 2017 Aug 08; 36(47). PMID: 28783170    Free PMC article.
Cell biology: Healthy skin rejects cancer.
Joseph Burclaff, Jason C Mills.
Nature, 2017 Aug 08; 548(7667). PMID: 28783724
Correction of aberrant growth preserves tissue homeostasis.
Samara Brown, Cristiana M Pineda, +8 authors, Valentina Greco.
Nature, 2017 Aug 08; 548(7667). PMID: 28783732    Free PMC article.
Highly Cited.
Role of MicroRNA-93 I in Pathogenesis of Left Ventricular Remodeling via Targeting Cyclin-D1.
Jingjing Zhang, Li Qin, +4 authors, Haili Shi.
Med Sci Monit, 2017 Aug 18; 23. PMID: 28817550    Free PMC article.
Complete sequence-based pathway analysis by differential on-chip DNA and RNA extraction from a single cell.
D van Strijp, R C M Vulders, +11 authors, P J van der Zaag.
Sci Rep, 2017 Sep 10; 7(1). PMID: 28887473    Free PMC article.
SATB2/β-catenin/TCF-LEF pathway induces cellular transformation by generating cancer stem cells in colorectal cancer.
Wei Yu, Yiming Ma, Sharmila Shankar, Rakesh K Srivastava.
Sci Rep, 2017 Sep 10; 7(1). PMID: 28887549    Free PMC article.
To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer.
Peng Shen, Martin Pichler, +2 authors, Hui Ling.
Int J Mol Sci, 2017 Sep 21; 18(9). PMID: 28930145    Free PMC article.
Review.
NOTCH1 activates the Wnt/β-catenin signaling pathway in colon cancer.
Hideyuki Ishiguro, Tomotaka Okubo, +12 authors, Shuji Takiguchi.
Oncotarget, 2017 Sep 28; 8(36). PMID: 28947978    Free PMC article.
CTNNB1 Mutation in Aldosterone Producing Adenoma.
Jian Jhong Wang, Kang Yung Peng, +2 authors, Kwan Dun Wu.
Endocrinol Metab (Seoul), 2017 Sep 29; 32(3). PMID: 28956362